Search of human proteins with 4557403

Search of human proteins with 4557403

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
         (301 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]         617   e-177
gi|86198310 solute carrier family 25, member 29 [Homo sapiens]        170   2e-42
gi|116235462 solute carrier family 25, member 45 isoform a [Homo...   161   6e-40
gi|13994341 solute carrier family 25 member 2 [Homo sapiens]          153   2e-37
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]        152   5e-37
gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]       149   3e-36
gi|116235466 solute carrier family 25, member 45 isoform b [Homo...   127   2e-29
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s...   119   3e-27
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo...   119   3e-27
gi|21361103 solute carrier family 25, member 12 [Homo sapiens]        117   2e-26
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy...   105   4e-23
gi|21314739 solute carrier family 25, member 32 [Homo sapiens]        104   8e-23
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit...   102   5e-22
gi|27544933 solute carrier family 25, member 16 [Homo sapiens]        102   5e-22
gi|7706306 solute carrier family 25, member 39 isoform b [Homo s...    97   2e-20
gi|11225256 uncoupling protein 1 [Homo sapiens]                        96   3e-20
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]           96   3e-20
gi|219555665 solute carrier family 25, member 39 isoform a [Homo...    94   1e-19
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ...    94   1e-19
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s...    94   1e-19
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]           93   3e-19
gi|14150082 mitochondrial carrier protein MGC4399 [Homo sapiens]       92   7e-19
gi|157388989 solute carrier family 25, member 36 isoform a [Homo...    91   2e-18
gi|157388925 solute carrier family 25, member 38 [Homo sapiens]        90   3e-18
gi|60460887 solute carrier family 25, member 42 [Homo sapiens]         89   4e-18
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]          89   6e-18
gi|13899342 solute carrier [Homo sapiens]                              89   6e-18
gi|13259541 uncoupling protein 2 [Homo sapiens]                        87   1e-17
gi|82775373 solute carrier family 25, member 37 [Homo sapiens]         87   2e-17
gi|157388991 solute carrier family 25, member 36 isoform b [Homo...    86   3e-17

>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
          Length = 301

 Score =  617 bits (1592), Expect = e-177
 Identities = 301/301 (100%), Positives = 301/301 (100%)

Query: 1   MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFR 60
           MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFR
Sbjct: 1   MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFR 60

Query: 61  KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLS 120
           KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLS
Sbjct: 61  KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLS 120

Query: 121 GVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDV 180
           GVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDV
Sbjct: 121 GVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDV 180

Query: 181 PASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTA 240
           PASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTA
Sbjct: 181 PASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTA 240

Query: 241 PPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWATPN 300
           PPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWATPN
Sbjct: 241 PPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWATPN 300

Query: 301 L 301
           L
Sbjct: 301 L 301


>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
          Length = 303

 Score =  170 bits (430), Expect = 2e-42
 Identities = 107/285 (37%), Positives = 154/285 (54%), Gaps = 17/285 (5%)

Query: 13  NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
           + LAG  GGV  V VGHP DTVKVRLQ Q      + P Y GT  CF+  + +E + GLY
Sbjct: 4   DFLAGCAGGVAGVLVGHPFDTVKVRLQVQSV----EKPQYRGTLHCFKSIIKQESVLGLY 59

Query: 73  RGMAAPIIGVTPMFAVCFFGFGL-GKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPG 131
           +G+ +P++G+T + A+ F   G+ G  L+    +  L+    F AG  +G     I  P 
Sbjct: 60  KGLGSPLMGLTFINALVF---GVQGNTLRALGHDSPLNQ---FLAGAAAGAIQCVICCPM 113

Query: 132 ERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYE 191
           E  K  LQ+Q +     Y G+LDC  ++Y   G+RG+ +G V TL+R+ P+ G+YF+TY+
Sbjct: 114 ELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYD 173

Query: 192 WLKNIFTPE-GKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYP--NG 248
            L      E G R   L  P++L+AGG +GI +W    P DV+KSR Q       P   G
Sbjct: 174 ALTRALGCEPGDR---LLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRG 230

Query: 249 FRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKF 293
             D + +  R EG     +G  + ++RAFP NAA F    V + +
Sbjct: 231 ILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFATVTVVLTY 275



 Score = 92.4 bits (228), Expect = 4e-19
 Identities = 58/181 (32%), Positives = 81/181 (44%), Gaps = 3/181 (1%)

Query: 9   SPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGI 68
           SPL   LAG   G     +  P++  K RLQ Q     G    Y G+ DC  +    EG+
Sbjct: 91  SPLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDA---GPARTYKGSLDCLAQIYGHEGL 147

Query: 69  TGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIM 128
            G+ RGM + ++  TP F V F  +    +     P D L  P+L  AG  SG+ +    
Sbjct: 148 RGVNRGMVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLST 207

Query: 129 TPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFM 188
            P + +K  LQ     G  +Y G LDC  + Y+  G R   +G   TL+R  P +   F 
Sbjct: 208 YPVDVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFA 267

Query: 189 T 189
           T
Sbjct: 268 T 268


>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
           sapiens]
          Length = 288

 Score =  161 bits (408), Expect = 6e-40
 Identities = 101/296 (34%), Positives = 145/296 (48%), Gaps = 23/296 (7%)

Query: 10  PLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGIT 69
           P++  +AG   G   + +GHP DTVKVRLQTQ          Y G  DC  K    E + 
Sbjct: 2   PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTT--------YRGIVDCMVKIYRHESLL 53

Query: 70  GLYRGMAAPIIGVTPMFAVCFFGFG-----LGKKLQQKHPEDVLSYPQLFAAGMLSGVFT 124
           G ++GM+ PI  +  + +V F  +      L     Q+      SY  +F AG   G   
Sbjct: 54  GFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQ 113

Query: 125 TGIMTPGERIKCLLQ------IQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMR 178
              + P + IK  LQ       Q  S   +Y G + CA  +++E G RG+++G     +R
Sbjct: 114 AYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLR 173

Query: 179 DVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQ 238
           D P  G+YF+TYE L   +TPEG+  S  +   +LVAGG AGI +W  A P D++KSR Q
Sbjct: 174 DTPTVGIYFITYEGLCRQYTPEGQNPSSAT---VLVAGGFAGIASWVAATPLDMIKSRMQ 230

Query: 239 -TAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKF 293
                 +   G  D +   IR EG+   ++G      RAFP NA  FL +E  +++
Sbjct: 231 MDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRW 286



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 60/193 (31%), Positives = 89/193 (46%), Gaps = 9/193 (4%)

Query: 6   KPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRL--QTQPPSLPGQ-PPMYSGTFDCFRKT 62
           +P S +   LAG  GG    +   P D +KVRL  QT+P + PG  PP Y G   C    
Sbjct: 95  QPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASI 154

Query: 63  LFREGITGLYRGMAAPIIGVTPMFAVCFFGF-GLGKKLQQKHPE-DVLSYPQLFAAGMLS 120
              EG  GL+RG  A  +  TP   + F  + GL    +Q  PE    S   +  AG  +
Sbjct: 155 FREEGPRGLFRGAWALTLRDTPTVGIYFITYEGL---CRQYTPEGQNPSSATVLVAGGFA 211

Query: 121 GVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDV 180
           G+ +    TP + IK  +Q+        Y G LDC     ++ G+   ++G  +   R  
Sbjct: 212 GIASWVAATPLDMIKSRMQMDGLR-RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAF 270

Query: 181 PASGMYFMTYEWL 193
           P + + F++YE+L
Sbjct: 271 PVNAVTFLSYEYL 283


>gi|13994341 solute carrier family 25 member 2 [Homo sapiens]
          Length = 301

 Score =  153 bits (387), Expect = 2e-37
 Identities = 96/291 (32%), Positives = 144/291 (49%), Gaps = 17/291 (5%)

Query: 13  NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
           +L AG  GG   V  G P DT+KV++QT P        +Y G  DCF KT  + G+ G Y
Sbjct: 12  DLTAGAAGGTACVLTGQPFDTIKVKMQTFPD-------LYKGLTDCFLKTYAQVGLRGFY 64

Query: 73  RGMAAPIIGVTPMFAVCFFGFGLGKKLQQK----HPEDVLSYPQLFAAGMLSGVFTTGIM 128
           +G    ++      +V F  +G  ++  +K      +  LS  Q  AAG  +  F    +
Sbjct: 65  KGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALAL 124

Query: 129 TPGERIKCLLQ----IQASSGESKYTGTL-DCAKKLYQEFGIRGIYKGTVLTLMRDVPAS 183
            P E +KC LQ    ++ S   +K   T+    K + ++ G  G Y G   TL+++VP  
Sbjct: 125 CPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGY 184

Query: 184 GMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPG 243
             +F  YE  ++ F   G+   EL    ++++GG+AGI  W V  P D +KSR Q     
Sbjct: 185 FFFFGGYELSRSFFA-SGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMY 243

Query: 244 KYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFL 294
               GF   L  ++R+EG+ +LY G  A MIRA PAN A F+ +E + K +
Sbjct: 244 GKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMM 294



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 47/197 (23%), Positives = 90/197 (45%), Gaps = 5/197 (2%)

Query: 3   DQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQ-PPSLPGQ-PPMYSGTFDCFR 60
           D+   +S L+   AG F          P + VK RLQT     + G+    ++  +   +
Sbjct: 99  DKQAKLSDLQTAAAGSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVK 158

Query: 61  KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKK-LQQKHPEDVLSYPQLFAAGML 119
             L ++G  G Y G+++ ++   P +   F G+ L +        +D L    L  +G +
Sbjct: 159 GILKKDGPLGFYHGLSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGV 218

Query: 120 SGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRD 179
           +G+    ++ P + IK  +Q+ +  G  K  G +     + +  GI  +Y G   T++R 
Sbjct: 219 AGICLWLVVFPVDCIKSRIQVLSMYG--KQAGFIGTLLSVVRNEGIVALYSGLKATMIRA 276

Query: 180 VPASGMYFMTYEWLKNI 196
           +PA+G  F+ YE+ + +
Sbjct: 277 IPANGALFVAYEYSRKM 293



 Score = 50.1 bits (118), Expect = 2e-06
 Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 5/98 (5%)

Query: 8   ISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREG 67
           + P+  +L+GG  G+CL  V  P+D +K R+Q    S+ G+   + GT       +  EG
Sbjct: 207 LGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVL--SMYGKQAGFIGT---LLSVVRNEG 261

Query: 68  ITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPE 105
           I  LY G+ A +I   P     F  +   +K+  K  E
Sbjct: 262 IVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLE 299


>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
          Length = 308

 Score =  152 bits (383), Expect = 5e-37
 Identities = 104/310 (33%), Positives = 154/310 (49%), Gaps = 40/310 (12%)

Query: 13  NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
           + +AG  GGVC V VG+PLDTVKVR+QT+        P Y+G + C R T  RE + G Y
Sbjct: 2   DFVAGAIGGVCGVAVGYPLDTVKVRIQTE--------PKYTGIWHCVRDTYHRERVWGFY 53

Query: 73  RGMAAPIIGVTPMFAVCF--FGFGLGK--KLQQKHPEDVLSYPQLFAAGMLSGVFTTGIM 128
           RG++ P+  V+ + +V F  +   L    +L+  +P+   +   +  +G  SG+    + 
Sbjct: 54  RGLSLPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLT 113

Query: 129 TPGERIKCLLQIQ----------ASSG---------------ESKYTGTLDCAKKLYQEF 163
           +P E  K  LQ Q          ++SG               E KY G L C   + +E 
Sbjct: 114 SPTEVAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREE 173

Query: 164 GIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFN 223
           G+ G+YKG+   ++RD  +   YF++Y  L    +P G   S    P +LVAGG AG+  
Sbjct: 174 GLCGLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGH--SRPDVPGVLVAGGCAGVLA 231

Query: 224 WAVAIPPDVLKSRFQTAPPG-KYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAA 282
           WAVA P DV+KSR Q    G +   G    +   +R+EG   L+KG      RAFP N  
Sbjct: 232 WAVATPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMV 291

Query: 283 CFLGFEVAMK 292
            F+ +E  ++
Sbjct: 292 VFVAYEAVLR 301



 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 54/212 (25%), Positives = 86/212 (40%), Gaps = 36/212 (16%)

Query: 114 FAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTV 173
           F AG + GV    +  P + +K  +Q      E KYTG   C +  Y    + G Y+G  
Sbjct: 3   FVAGAIGGVCGVAVGYPLDTVKVRIQT-----EPKYTGIWHCVRDTYHRERVWGFYRGLS 57

Query: 174 LTLMRDVPASGMYFMTYEW-LKNIFTPE-GKRVSELSAPRILVAGGIAGIFNWAVAIPPD 231
           L +      S + F TY   L +I     G   ++ +   I ++G  +G+    +  P +
Sbjct: 58  LPVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVRVFLTSPTE 117

Query: 232 VLKSRFQT----------------------------APPGKYPNGFRDVLRELIRDEGVT 263
           V K R QT                             P  KY  G    L  + R+EG+ 
Sbjct: 118 VAKVRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKY-RGPLHCLATVAREEGLC 176

Query: 264 SLYKGFNAVMIRAFPANAACFLGFEVAMKFLN 295
            LYKG +A+++R   + A  FL + V  ++L+
Sbjct: 177 GLYKGSSALVLRDGHSFATYFLSYAVLCEWLS 208


>gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]
          Length = 301

 Score =  149 bits (376), Expect = 3e-36
 Identities = 95/291 (32%), Positives = 143/291 (49%), Gaps = 17/291 (5%)

Query: 13  NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
           +L AG  GG   V  G P DT+KV++QT P        +Y G  DC  KT  + G  G Y
Sbjct: 12  DLTAGAAGGTACVLTGQPFDTMKVKMQTFPD-------LYRGLTDCCLKTYSQVGFRGFY 64

Query: 73  RGMAAPIIGVTPMFAVCFFGFGLGKKLQQK----HPEDVLSYPQLFAAGMLSGVFTTGIM 128
           +G +  +I      +V F  +G  +++ +K      +  LS  Q  AAG  +  F   ++
Sbjct: 65  KGTSPALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFASAFAALVL 124

Query: 129 TPGERIKCLLQ----IQASSGESKYTGTL-DCAKKLYQEFGIRGIYKGTVLTLMRDVPAS 183
            P E +KC LQ    ++ S   +K   T+    K + ++ G  G Y G   TL+R+VP  
Sbjct: 125 CPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGY 184

Query: 184 GMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPG 243
             +F  YE  ++ F   G+   EL    ++++GG+ GI  W    P D +KSR Q     
Sbjct: 185 FFFFGGYELSRSFFA-SGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMS 243

Query: 244 KYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFL 294
               GF      ++++EG+T+LY G    MIRAFPAN A FL +E + K +
Sbjct: 244 GKQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLM 294



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 51/197 (25%), Positives = 88/197 (44%), Gaps = 5/197 (2%)

Query: 3   DQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQ-PPSLPGQPPMYSGT-FDCFR 60
           D+   +S L+N  AG F       V  P + VK RLQT       G+      T +   +
Sbjct: 99  DKQAKLSDLQNAAAGSFASAFAALVLCPTELVKCRLQTMYEMETSGKIAKSQNTVWSVIK 158

Query: 61  KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKK-LQQKHPEDVLSYPQLFAAGML 119
             L ++G  G Y G+++ ++   P +   F G+ L +        +D L    L  +G +
Sbjct: 159 SILRKDGPLGFYHGLSSTLLREVPGYFFFFGGYELSRSFFASGRSKDELGPVPLMLSGGV 218

Query: 120 SGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRD 179
            G+     + P + IK  +Q+ + SG  K  G +     + +  GI  +Y G   T++R 
Sbjct: 219 GGICLWLAVYPVDCIKSRIQVLSMSG--KQAGFIRTFINVVKNEGITALYSGLKPTMIRA 276

Query: 180 VPASGMYFMTYEWLKNI 196
            PA+G  F+ YE+ + +
Sbjct: 277 FPANGALFLAYEYSRKL 293



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 5/98 (5%)

Query: 8   ISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREG 67
           + P+  +L+GG GG+CL    +P+D +K R+Q    S+ G+    +G    F   +  EG
Sbjct: 207 LGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVL--SMSGK---QAGFIRTFINVVKNEG 261

Query: 68  ITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPE 105
           IT LY G+   +I   P     F  +   +KL     E
Sbjct: 262 ITALYSGLKPTMIRAFPANGALFLAYEYSRKLMMNQLE 299


>gi|116235466 solute carrier family 25, member 45 isoform b [Homo
           sapiens]
          Length = 246

 Score =  127 bits (318), Expect = 2e-29
 Identities = 79/240 (32%), Positives = 118/240 (49%), Gaps = 15/240 (6%)

Query: 66  EGITGLYRGMAAPIIGVTPMFAVCFFGFG-----LGKKLQQKHPEDVLSYPQLFAAGMLS 120
           E + G ++GM+ PI  +  + +V F  +      L     Q+      SY  +F AG   
Sbjct: 8   ESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTG 67

Query: 121 GVFTTGIMTPGERIKCLLQ------IQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVL 174
           G      + P + IK  LQ       Q  S   +Y G + CA  +++E G RG+++G   
Sbjct: 68  GFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWA 127

Query: 175 TLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLK 234
             +RD P  G+YF+TYE L   +TPEG+  S  +   +LVAGG AGI +W  A P D++K
Sbjct: 128 LTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSAT---VLVAGGFAGIASWVAATPLDMIK 184

Query: 235 SRFQ-TAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKF 293
           SR Q      +   G  D +   IR EG+   ++G      RAFP NA  FL +E  +++
Sbjct: 185 SRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRW 244



 Score = 77.0 bits (188), Expect = 2e-14
 Identities = 60/193 (31%), Positives = 89/193 (46%), Gaps = 9/193 (4%)

Query: 6   KPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQ--TQPPSLPGQPP-MYSGTFDCFRKT 62
           +P S +   LAG  GG    +   P D +KVRLQ  T+P + PG PP  Y G   C    
Sbjct: 53  QPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASI 112

Query: 63  LFREGITGLYRGMAAPIIGVTPMFAVCFFGF-GLGKKLQQKHPE-DVLSYPQLFAAGMLS 120
              EG  GL+RG  A  +  TP   + F  + GL    +Q  PE    S   +  AG  +
Sbjct: 113 FREEGPRGLFRGAWALTLRDTPTVGIYFITYEGL---CRQYTPEGQNPSSATVLVAGGFA 169

Query: 121 GVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDV 180
           G+ +    TP + IK  +Q+        Y G LDC     ++ G+   ++G  +   R  
Sbjct: 170 GIASWVAATPLDMIKSRMQMDGLR-RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAF 228

Query: 181 PASGMYFMTYEWL 193
           P + + F++YE+L
Sbjct: 229 PVNAVTFLSYEYL 241


>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
           sapiens]
          Length = 675

 Score =  119 bits (298), Expect = 3e-27
 Identities = 93/286 (32%), Positives = 140/286 (48%), Gaps = 23/286 (8%)

Query: 15  LAGGFGGVCLVFVGHPLDTVKVRLQTQ--PPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
           +AG  G   +    +P+D VK R+Q Q    S  G+  MY  +FDCF+K L  EG  GLY
Sbjct: 337 VAGAVGATAV----YPIDLVKTRMQNQRSTGSFVGE-LMYKNSFDCFKKVLRYEGFFGLY 391

Query: 73  RGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSG---VFTTGIMT 129
           RG+   ++GV P  A+        +         V    ++ A G   G   +FT     
Sbjct: 392 RGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFT----N 447

Query: 130 PGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMT 189
           P E +K  LQ+   +GE   TG    A  + ++ G  GIYKG     +RD+P S +YF  
Sbjct: 448 PLEIVKIRLQV---AGEIT-TGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPC 503

Query: 190 YEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYP--N 247
           Y  +K  F  E  +VS  S   +L+AG IAG+   ++  P DV+K+R Q A        +
Sbjct: 504 YAHVKASFANEDGQVSPGS---LLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYS 560

Query: 248 GFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKF 293
           G  D  R+++R+EG  +L+KG  A + R+ P      L +E+  ++
Sbjct: 561 GVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRW 606



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 56/185 (30%), Positives = 93/185 (50%), Gaps = 10/185 (5%)

Query: 14  LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFRE-GITGLY 72
           +LAGG  G   V   +PL+ VK+RLQ       G  P  S        ++ R+ G  G+Y
Sbjct: 432 ILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTG--PRVSAL------SVVRDLGFFGIY 483

Query: 73  RGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGE 132
           +G  A  +   P F+  +F      K    + +  +S   L  AG ++G+    ++TP +
Sbjct: 484 KGAKACFLRDIP-FSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPAD 542

Query: 133 RIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEW 192
            IK  LQ+ A +G++ Y+G +DC +K+ +E G + ++KG    + R  P  G+  +TYE 
Sbjct: 543 VIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYEL 602

Query: 193 LKNIF 197
           L+  F
Sbjct: 603 LQRWF 607



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 34/94 (36%), Positives = 46/94 (48%), Gaps = 3/94 (3%)

Query: 2   ADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRK 61
           A++   +SP   LLAG   G+    +  P D +K RLQ    +  GQ   YSG  DCFRK
Sbjct: 512 ANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQV--AARAGQ-TTYSGVIDCFRK 568

Query: 62  TLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGL 95
            L  EG   L++G  A +   +P F V    + L
Sbjct: 569 ILREEGPKALWKGAGARVFRSSPQFGVTLLTYEL 602



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 20/73 (27%), Positives = 31/73 (42%), Gaps = 8/73 (10%)

Query: 216 GGIAGIFNWAVAIPPDVLKSRFQTAPPG-------KYPNGFRDVLRELIRDEGVTSLYKG 268
           G +AG        P D++K+R Q             Y N F D  ++++R EG   LY+G
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSF-DCFKKVLRYEGFFGLYRG 393

Query: 269 FNAVMIRAFPANA 281
               ++   P  A
Sbjct: 394 LLPQLLGVAPEKA 406


>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
           sapiens]
          Length = 676

 Score =  119 bits (298), Expect = 3e-27
 Identities = 93/286 (32%), Positives = 140/286 (48%), Gaps = 23/286 (8%)

Query: 15  LAGGFGGVCLVFVGHPLDTVKVRLQTQ--PPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
           +AG  G   +    +P+D VK R+Q Q    S  G+  MY  +FDCF+K L  EG  GLY
Sbjct: 338 VAGAVGATAV----YPIDLVKTRMQNQRSTGSFVGE-LMYKNSFDCFKKVLRYEGFFGLY 392

Query: 73  RGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSG---VFTTGIMT 129
           RG+   ++GV P  A+        +         V    ++ A G   G   +FT     
Sbjct: 393 RGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQVIFT----N 448

Query: 130 PGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMT 189
           P E +K  LQ+   +GE   TG    A  + ++ G  GIYKG     +RD+P S +YF  
Sbjct: 449 PLEIVKIRLQV---AGEIT-TGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPC 504

Query: 190 YEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYP--N 247
           Y  +K  F  E  +VS  S   +L+AG IAG+   ++  P DV+K+R Q A        +
Sbjct: 505 YAHVKASFANEDGQVSPGS---LLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYS 561

Query: 248 GFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKF 293
           G  D  R+++R+EG  +L+KG  A + R+ P      L +E+  ++
Sbjct: 562 GVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRW 607



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 56/185 (30%), Positives = 93/185 (50%), Gaps = 10/185 (5%)

Query: 14  LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFRE-GITGLY 72
           +LAGG  G   V   +PL+ VK+RLQ       G  P  S        ++ R+ G  G+Y
Sbjct: 433 ILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTG--PRVSAL------SVVRDLGFFGIY 484

Query: 73  RGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGE 132
           +G  A  +   P F+  +F      K    + +  +S   L  AG ++G+    ++TP +
Sbjct: 485 KGAKACFLRDIP-FSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPAD 543

Query: 133 RIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEW 192
            IK  LQ+ A +G++ Y+G +DC +K+ +E G + ++KG    + R  P  G+  +TYE 
Sbjct: 544 VIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYEL 603

Query: 193 LKNIF 197
           L+  F
Sbjct: 604 LQRWF 608



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 34/94 (36%), Positives = 46/94 (48%), Gaps = 3/94 (3%)

Query: 2   ADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRK 61
           A++   +SP   LLAG   G+    +  P D +K RLQ    +  GQ   YSG  DCFRK
Sbjct: 513 ANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQV--AARAGQ-TTYSGVIDCFRK 569

Query: 62  TLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGL 95
            L  EG   L++G  A +   +P F V    + L
Sbjct: 570 ILREEGPKALWKGAGARVFRSSPQFGVTLLTYEL 603



 Score = 30.0 bits (66), Expect = 2.6
 Identities = 20/73 (27%), Positives = 31/73 (42%), Gaps = 8/73 (10%)

Query: 216 GGIAGIFNWAVAIPPDVLKSRFQTAPPG-------KYPNGFRDVLRELIRDEGVTSLYKG 268
           G +AG        P D++K+R Q             Y N F D  ++++R EG   LY+G
Sbjct: 336 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSF-DCFKKVLRYEGFFGLYRG 394

Query: 269 FNAVMIRAFPANA 281
               ++   P  A
Sbjct: 395 LLPQLLGVAPEKA 407


>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
          Length = 678

 Score =  117 bits (292), Expect = 2e-26
 Identities = 89/286 (31%), Positives = 140/286 (48%), Gaps = 23/286 (8%)

Query: 15  LAGGFGGVCLVFVGHPLDTVKVRLQTQ--PPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
           +AG  G   +    +P+D VK R+Q Q    S+ G+  MY  +FDCF+K L  EG  GLY
Sbjct: 335 VAGAVGATAV----YPIDLVKTRMQNQRGSGSVVGE-LMYKNSFDCFKKVLRYEGFFGLY 389

Query: 73  RGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSG---VFTTGIMT 129
           RG+   +IGV P  A+        +    +    V    ++ A G   G   +FT     
Sbjct: 390 RGLIPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQVIFT----N 445

Query: 130 PGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMT 189
           P E +K  LQ+   +GE   TG    A  + ++ GI G+YKG     +RD+P S +YF  
Sbjct: 446 PLEIVKIRLQV---AGEIT-TGPRVSALNVLRDLGIFGLYKGAKACFLRDIPFSAIYFPV 501

Query: 190 YEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYP--N 247
           Y   K +   E   V  L+   +L AG +AG+   ++  P DV+K+R Q A        +
Sbjct: 502 YAHCKLLLADENGHVGGLN---LLAAGAMAGVPAASLVTPADVIKTRLQVAARAGQTTYS 558

Query: 248 GFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKF 293
           G  D  R+++R+EG ++ +KG  A + R+ P      + +E+  ++
Sbjct: 559 GVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRW 604



 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 62/184 (33%), Positives = 89/184 (48%), Gaps = 8/184 (4%)

Query: 14  LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYR 73
           +LAGG  G   V   +PL+ VK+RLQ       G  P  S         L   GI GLY+
Sbjct: 430 VLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTG--PRVSAL-----NVLRDLGIFGLYK 482

Query: 74  GMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGER 133
           G  A  +   P  A+ F  +   K L       V     L AAG ++GV    ++TP + 
Sbjct: 483 GAKACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGL-NLLAAGAMAGVPAASLVTPADV 541

Query: 134 IKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWL 193
           IK  LQ+ A +G++ Y+G +DC +K+ +E G    +KGT   + R  P  G+  +TYE L
Sbjct: 542 IKTRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELL 601

Query: 194 KNIF 197
           +  F
Sbjct: 602 QRWF 605



 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 34/95 (35%), Positives = 46/95 (48%), Gaps = 3/95 (3%)

Query: 1   MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFR 60
           +AD+   +  L  L AG   GV    +  P D +K RLQ    +  GQ   YSG  DCFR
Sbjct: 509 LADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQV--AARAGQ-TTYSGVIDCFR 565

Query: 61  KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGL 95
           K L  EG +  ++G AA +   +P F V    + L
Sbjct: 566 KILREEGPSAFWKGTAARVFRSSPQFGVTLVTYEL 600



 Score = 31.2 bits (69), Expect = 1.2
 Identities = 21/73 (28%), Positives = 31/73 (42%), Gaps = 8/73 (10%)

Query: 216 GGIAGIFNWAVAIPPDVLKSRFQTAPPG-------KYPNGFRDVLRELIRDEGVTSLYKG 268
           G +AG        P D++K+R Q             Y N F D  ++++R EG   LY+G
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSF-DCFKKVLRYEGFFGLYRG 391

Query: 269 FNAVMIRAFPANA 281
               +I   P  A
Sbjct: 392 LIPQLIGVAPEKA 404


>gi|13449279 solute carrier family 25 (mitochondrial
           oxodicarboxylate carrier), member 21 [Homo sapiens]
          Length = 299

 Score =  105 bits (263), Expect = 4e-23
 Identities = 93/299 (31%), Positives = 142/299 (47%), Gaps = 28/299 (9%)

Query: 12  KNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGL 71
           + ++AGG  G+  + + HPLD VK R Q Q  +    P  Y    D FR     EG+ G 
Sbjct: 15  RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCAT--DPNSYKSLVDSFRMIFQMEGLFGF 72

Query: 72  YRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQL-----FA-AGMLSGVFTT 125
           Y+G+  PI+  TP  AV FF F   KKL        L Y  L     FA AG+ SG+   
Sbjct: 73  YKGILPPILAETPKRAVKFFTFEQYKKL--------LGYVSLSPALTFAIAGLGSGLTEA 124

Query: 126 GIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQE--FGIRGIYKGTVLTLMRDVPAS 183
            ++ P E +K  LQ   ++  ++   T+  A+++ ++  +G++G+ KG   TL R    +
Sbjct: 125 IVVNPFEVVKVGLQANRNT-FAEQPSTVGYARQIIKKEGWGLQGLNKGLTATLGRHGVFN 183

Query: 184 GMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPG 243
            +YF  Y  +KN+       + E    R    G ++G     + IP DV KSR Q   P 
Sbjct: 184 MVYFGFYYNVKNMIPVNKDPILEFW--RKFGIGLLSGTIASVINIPFDVAKSRIQGPQPV 241

Query: 244 ----KYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFL--NW 296
               KY   F+  +  + ++EG+ +LYKG    ++R  P  A   L +E    +L  NW
Sbjct: 242 PGEIKYRTCFK-TMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQENW 299



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 35/103 (33%), Positives = 49/103 (47%), Gaps = 5/103 (4%)

Query: 199 PEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFR---DVLRE 255
           PE   V E S  R +VAGG AG+    +  P DV+K+RFQ       PN ++   D  R 
Sbjct: 5   PEVSLVREAS--RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRM 62

Query: 256 LIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLNWAT 298
           + + EG+   YKG    ++   P  A  F  FE   K L + +
Sbjct: 63  IFQMEGLFGFYKGILPPILAETPKRAVKFFTFEQYKKLLGYVS 105


>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
          Length = 315

 Score =  104 bits (260), Expect = 8e-23
 Identities = 85/289 (29%), Positives = 125/289 (43%), Gaps = 11/289 (3%)

Query: 12  KNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGL 71
           +NL+AG  GGV      HPLD VK+R            P Y+G   C       +G+ GL
Sbjct: 24  ENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGL--ELRPKYNGILHCLTTIWKLDGLRGL 81

Query: 72  YRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPG 131
           Y+G+   I G    + + FF +   K  + +   + L   +   +   +G  T  I  P 
Sbjct: 82  YQGVTPNIWGAGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAGAMTLCITNPL 141

Query: 132 ERIKCLLQIQ----ASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYF 187
              K  L +Q     +S   +Y G  D   K+Y+  G+RG+YKG V  L        + F
Sbjct: 142 WVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLF-GTSHGALQF 200

Query: 188 MTYEWLKNIFTPEGKRVSE--LSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKY 245
           M YE LK  +     R+ E  LS    +    ++ IF  A   P  V+++R Q      +
Sbjct: 201 MAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQ--DQHMF 258

Query: 246 PNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFL 294
            +G  DV+ +  R EGV   YKG    +IR  PA    F+ +E    FL
Sbjct: 259 YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 25/83 (30%), Positives = 38/83 (45%), Gaps = 7/83 (8%)

Query: 8   ISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREG 67
           +S ++ +       +  V   +P   V+ RLQ Q          YSG  D   KT  +EG
Sbjct: 222 LSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHM-------FYSGVIDVITKTWRKEG 274

Query: 68  ITGLYRGMAAPIIGVTPMFAVCF 90
           + G Y+G+A  +I VTP   + F
Sbjct: 275 VGGFYKGIAPNLIRVTPACCITF 297


>gi|21389315 solute carrier family 25 (mitochondrial carrier;
           citrate transporter), member 1 precursor [Homo sapiens]
          Length = 311

 Score =  102 bits (253), Expect = 5e-22
 Identities = 87/296 (29%), Positives = 136/296 (45%), Gaps = 17/296 (5%)

Query: 10  PLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGIT 69
           P K +LAGG  G   + +  P + VK +LQ    S    PP Y G  DC R+T+   G+ 
Sbjct: 25  PGKAILAGGLAGGIEICITFPTEYVKTQLQLDERS---HPPRYRGIGDCVRQTVRSHGVL 81

Query: 70  GLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDV---LSYPQLFAAGMLSGVF-TT 125
           GLYRG+++ + G  P  AV F  F    +    H  D    L   +    G+ +GV    
Sbjct: 82  GLYRGLSSLLYGSIPKAAVRFGMF----EFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAV 137

Query: 126 GIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGM 185
            ++ P E IK       +S   KY G     +++ +E G++G Y+G   T+++      +
Sbjct: 138 VVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAI 197

Query: 186 YFMTYEWLKNIFTPEGKRVSELSAPRIL-VAGGIAGIFNWAVAIPPDVLKSRFQTAPPGK 244
            F     L+N +   G   ++   P I  V G IAG  +     P DV+K+R Q     K
Sbjct: 198 RFFVMTSLRNWY--RGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHK 255

Query: 245 YPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLN--WAT 298
           Y N + D   ++++ EG+ + YKG    + R     A  F+ ++  +K LN  W T
Sbjct: 256 YRNTW-DCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKT 310



 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 57/194 (29%), Positives = 94/194 (48%), Gaps = 12/194 (6%)

Query: 108 LSYP-QLFAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIR 166
           L++P +   AG L+G     I  P E +K  LQ+   S   +Y G  DC ++  +  G+ 
Sbjct: 22  LTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVL 81

Query: 167 GIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAV 226
           G+Y+G    L   +P + + F  +E+L N       R   L + R L+ G  AG+    V
Sbjct: 82  GLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGR---LDSTRGLLCGLGAGVAEAVV 138

Query: 227 AI-PPDVLKSRF---QTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAA 282
            + P + +K +F   QT+P  KY  GF   +RE++R++G+   Y+G  A +++     A 
Sbjct: 139 VVCPMETIKVKFIHDQTSPNPKY-RGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQA- 196

Query: 283 CFLGFEVAMKFLNW 296
             + F V     NW
Sbjct: 197 --IRFFVMTSLRNW 208



 Score = 43.1 bits (100), Expect = 3e-04
 Identities = 31/101 (30%), Positives = 45/101 (44%), Gaps = 7/101 (6%)

Query: 3   DQP-KPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRK 61
           D P KP++PL   + G   G   VF   PLD +K R+Q        +   Y  T+DC  +
Sbjct: 212 DNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGL------EAHKYRNTWDCGLQ 265

Query: 62  TLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQK 102
            L +EG+   Y+G    +  V    A+ F  +    KL  K
Sbjct: 266 ILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNK 306


>gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
          Length = 332

 Score =  102 bits (253), Expect = 5e-22
 Identities = 83/301 (27%), Positives = 130/301 (43%), Gaps = 23/301 (7%)

Query: 11  LKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITG 70
           L++ LAGG  G C      PLD VKV LQ            + G F   R    +EG  G
Sbjct: 37  LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAH-----NHHYKHLGVFSALRAVPQKEGFLG 91

Query: 71  LYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTP 130
           LY+G  A +I + P  A+ F  F   K L       +  +     AG ++G+       P
Sbjct: 92  LYKGNGAMMIRIFPYGAIQFMAFEHYKTLITT-KLGISGHVHRLMAGSMAGMTAVICTYP 150

Query: 131 GERIKCLLQIQASSGESKYTGTLDCAKKLY-QEFGIRGIYKGTVLTLMRDVPASGMYFMT 189
            + ++  L  Q   GE  YTG +   K +Y +E G  G Y+G + T++   P +G+ F T
Sbjct: 151 LDMVRVRLAFQV-KGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSFFT 209

Query: 190 YEWLKNIF-----------TPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQ 238
           +  LK++            + +   V  L     L+ GG+AG     ++ P DV + R Q
Sbjct: 210 FGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDVTRRRMQ 269

Query: 239 ---TAPPGKYPNGFRDVLRELIRDEGV-TSLYKGFNAVMIRAFPANAACFLGFEVAMKFL 294
                P  +     RD ++ +    G+   LY+G +   IR  P+ A  F  +E+  +F 
Sbjct: 270 LGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYELMKQFF 329

Query: 295 N 295
           +
Sbjct: 330 H 330


>gi|7706306 solute carrier family 25, member 39 isoform b [Homo
           sapiens]
          Length = 351

 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 94/348 (27%), Positives = 143/348 (41%), Gaps = 64/348 (18%)

Query: 1   MADQ-PKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQ----------- 48
           MADQ P  ISPL+ ++A G G V       PLD VKVRLQ+Q PS+  +           
Sbjct: 1   MADQDPAGISPLQQMVASGTGAVVTSLFMTPLDVVKVRLQSQRPSMASELMPSSRLWSLS 60

Query: 49  --------------------------------PPMYSGTFDCFRKTLFREGITGLYRGMA 76
                                           P  ++GT D F K +  EG   L+ G+ 
Sbjct: 61  YTKWKCLLYCNGVLEPLYLCPNGARCATWFQDPTRFTGTMDAFVKIVRHEGTRTLWSGLP 120

Query: 77  APIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGERIKC 136
           A ++   P  A+ F  +   K            Y  +  AG L+ + T  +++P E ++ 
Sbjct: 121 ATLVMTVPATAIYFTAYDQLKAFLCGRALTSDLYAPM-VAGALARLGTVTVISPLELMRT 179

Query: 137 LLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWLK-- 194
            LQ Q  S    Y     C +    + G R ++ G   T +RDVP S +Y+  YE +K  
Sbjct: 180 KLQAQHVS----YRELGACVRTAVAQGGWRSLWLGWGPTALRDVPFSALYWFNYELVKSW 235

Query: 195 -NIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGK--------Y 245
            N F P+     + S     VAGGI+G     + +P DV+K++ Q A            +
Sbjct: 236 LNGFRPK----DQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLH 291

Query: 246 PNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKF 293
            +    +LR +  + G   L+ GF   +I+A P+ A     +E    F
Sbjct: 292 VDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSF 339



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 45/191 (23%), Positives = 81/191 (42%), Gaps = 14/191 (7%)

Query: 14  LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYR 73
           ++AG    +  V V  PL+ ++ +LQ Q  S       Y     C R  + + G   L+ 
Sbjct: 157 MVAGALARLGTVTVISPLELMRTKLQAQHVS-------YRELGACVRTAVAQGGWRSLWL 209

Query: 74  GMAAPIIGVTPMFAVCFFGFGLGKK-LQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGE 132
           G     +   P  A+ +F + L K  L    P+D  S    F AG +SG     +  P +
Sbjct: 210 GWGPTALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFD 269

Query: 133 RIKCLLQIQASSGESKYTGTLDC------AKKLYQEFGIRGIYKGTVLTLMRDVPASGMY 186
            +K   Q+   + E+     L         +++  E G +G++ G +  +++  P+  + 
Sbjct: 270 VVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIM 329

Query: 187 FMTYEWLKNIF 197
             TYE+ K+ F
Sbjct: 330 ISTYEFGKSFF 340



 Score = 35.0 bits (79), Expect = 0.081
 Identities = 25/99 (25%), Positives = 38/99 (38%), Gaps = 3/99 (3%)

Query: 13  NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPG---QPPMYSGTFDCFRKTLFREGIT 69
           + +AGG  G     +  P D VK + Q    ++      P     T+   R+     G  
Sbjct: 250 SFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTK 309

Query: 70  GLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVL 108
           GL+ G    II   P  A+    +  GK   Q+  +D L
Sbjct: 310 GLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQDRL 348


>gi|11225256 uncoupling protein 1 [Homo sapiens]
          Length = 307

 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 80/280 (28%), Positives = 122/280 (43%), Gaps = 11/280 (3%)

Query: 14  LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYR 73
           L + G        +  PLDT KVRLQ Q          Y G        +  EG   LY 
Sbjct: 17  LFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYS 76

Query: 74  GMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQL---FAAGMLSGVFTTGIMTP 130
           G+ A   G+    +      GL   +Q+       + P L     AG+ +G     I  P
Sbjct: 77  GLPA---GLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQP 133

Query: 131 GERIKCLLQIQASSG--ESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFM 188
            E +K  LQ Q+     + +YTGT +  + +    G+ G++KGT   LMR V  +    +
Sbjct: 134 TEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELV 193

Query: 189 TYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNG 248
           TY+ +K  F        ++  P  LV+  IAG    A++ P DV+K+RF  +PPG+Y   
Sbjct: 194 TYDLMKEAFVKNNILADDV--PCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQY-KS 250

Query: 249 FRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFE 288
             +   ++  +EG T+ +KG     +R    N   F+ FE
Sbjct: 251 VPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFE 290



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 50/181 (27%), Positives = 86/181 (47%), Gaps = 4/181 (2%)

Query: 14  LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYR 73
           +LAG   G   VF+G P + VKVRLQ Q   L G  P Y+GT++ +R     EG+TGL++
Sbjct: 117 ILAGLTTGGVAVFIGQPTEVVKVRLQAQS-HLHGIKPRYTGTYNAYRIIATTEGLTGLWK 175

Query: 74  GMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGER 133
           G    ++    +       + L K+   K+       P    + +++G   T + +P + 
Sbjct: 176 GTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDV 235

Query: 134 IKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWL 193
           +K       +S   +Y    +CA K++   G    +KG V + +R    + + F+ +E L
Sbjct: 236 VKTRF---INSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQL 292

Query: 194 K 194
           K
Sbjct: 293 K 293



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 47/188 (25%), Positives = 82/188 (43%), Gaps = 16/188 (8%)

Query: 112 QLFAAGMLSGVFTTGIMTPGERIKCLLQIQA---SSGESKYTGTLDCAKKLYQEFGIRGI 168
           QLF+AG ++      I  P +  K  LQ+Q    +S   +Y G L     + +  G   +
Sbjct: 16  QLFSAG-IAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKL 74

Query: 169 YKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVA---GGIAGIFNWA 225
           Y G    L R + ++ +    Y+ ++   T  GK  +     +IL     GG+A +F   
Sbjct: 75  YSGLPAGLQRQISSASLRIGLYDTVQEFLTA-GKETAPSLGSKILAGLTTGGVA-VF--- 129

Query: 226 VAIPPDVLKSRFQTAPP--GKYPN--GFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANA 281
           +  P +V+K R Q      G  P   G  +  R +   EG+T L+KG    ++R+   N 
Sbjct: 130 IGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINC 189

Query: 282 ACFLGFEV 289
              + +++
Sbjct: 190 TELVTYDL 197



 Score = 34.3 bits (77), Expect = 0.14
 Identities = 19/81 (23%), Positives = 31/81 (38%), Gaps = 6/81 (7%)

Query: 13  NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
           +L++    G C   +  P+D VK R    PP        Y    +C  K    EG T  +
Sbjct: 215 HLVSALIAGFCATAMSSPVDVVKTRFINSPPG------QYKSVPNCAMKVFTNEGPTAFF 268

Query: 73  RGMAAPIIGVTPMFAVCFFGF 93
           +G+    + +     + F  F
Sbjct: 269 KGLVPSFLRLGSWNVIMFVCF 289


>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
          Length = 312

 Score = 96.3 bits (238), Expect = 3e-20
 Identities = 82/297 (27%), Positives = 124/297 (41%), Gaps = 18/297 (6%)

Query: 4   QPKPISPLK--NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPP---MYSGTFDC 58
           +P  + P      L  G        V  PLDT KVRLQ Q  +   Q      Y G    
Sbjct: 5   KPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGT 64

Query: 59  FRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPE---DVLSYPQLFA 115
               +  EG    Y G+ A   G+    +      GL   ++Q +     D  S      
Sbjct: 65  ILTMVRTEGPCSPYNGLVA---GLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRIL 121

Query: 116 AGMLSGVFTTGIMTPGERIKCLLQIQASSGES----KYTGTLDCAKKLYQEFGIRGIYKG 171
           AG  +G        P + +K   Q     G S    KY+GT+D  + + +E G+RG++KG
Sbjct: 122 AGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKG 181

Query: 172 TVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPD 231
           T+  +MR+   +    +TY+ LK               P   V+   AG     VA P D
Sbjct: 182 TLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNF--PCHFVSAFGAGFCATVVASPVD 239

Query: 232 VLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFE 288
           V+K+R+  +PPG+Y +   D + +++  EG T+ YKGF    +R    N   F+ +E
Sbjct: 240 VVKTRYMNSPPGQYFSPL-DCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYE 295



 Score = 58.9 bits (141), Expect = 5e-09
 Identities = 49/182 (26%), Positives = 78/182 (42%), Gaps = 4/182 (2%)

Query: 14  LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPM-YSGTFDCFRKTLFREGITGLY 72
           +LAG   G   V    P D VKVR Q      P +    YSGT D +R     EG+ GL+
Sbjct: 120 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW 179

Query: 73  RGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGE 132
           +G    I+    +       + + K+    +     ++P  F +   +G   T + +P +
Sbjct: 180 KGTLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVD 239

Query: 133 RIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEW 192
            +K       +S   +Y   LDC  K+  + G    YKG   + +R    + + F+TYE 
Sbjct: 240 VVKTRYM---NSPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQ 296

Query: 193 LK 194
           LK
Sbjct: 297 LK 298



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 53/189 (28%), Positives = 81/189 (42%), Gaps = 16/189 (8%)

Query: 114 FAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESK------YTGTLDCAKKLYQEFGIRG 167
           F     +  F   +  P +  K  LQIQ  +   +      Y G L     + +  G   
Sbjct: 17  FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76

Query: 168 IYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVA 227
            Y G V  L R +  + +    Y+ +K ++TP+G   S L+  RIL AG   G      A
Sbjct: 77  PYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTT-RIL-AGCTTGAMAVTCA 134

Query: 228 IPPDVLKSRFQTA-------PPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPAN 280
            P DV+K RFQ +          KY +G  D  R + R+EGV  L+KG    ++R    N
Sbjct: 135 QPTDVVKVRFQASIHLGPSRSDRKY-SGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVN 193

Query: 281 AACFLGFEV 289
            A  + +++
Sbjct: 194 CAEVVTYDI 202



 Score = 38.9 bits (89), Expect = 0.006
 Identities = 23/82 (28%), Positives = 31/82 (37%), Gaps = 6/82 (7%)

Query: 21  GVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYRGMAAPII 80
           G C   V  P+D VK R    PP        Y    DC  K + +EG T  Y+G     +
Sbjct: 228 GFCATVVASPVDVVKTRYMNSPPG------QYFSPLDCMIKMVAQEGPTAFYKGFTPSFL 281

Query: 81  GVTPMFAVCFFGFGLGKKLQQK 102
            +     V F  +   K+   K
Sbjct: 282 RLGSWNVVMFVTYEQLKRALMK 303


>gi|219555665 solute carrier family 25, member 39 isoform a [Homo
           sapiens]
          Length = 359

 Score = 94.0 bits (232), Expect = 1e-19
 Identities = 94/356 (26%), Positives = 143/356 (40%), Gaps = 72/356 (20%)

Query: 1   MADQ-PKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQ----------- 48
           MADQ P  ISPL+ ++A G G V       PLD VKVRLQ+Q PS+  +           
Sbjct: 1   MADQDPAGISPLQQMVASGTGAVVTSLFMTPLDVVKVRLQSQRPSMASELMPSSRLWSLS 60

Query: 49  ----------------------------------------PPMYSGTFDCFRKTLFREGI 68
                                                   P  ++GT D F K +  EG 
Sbjct: 61  YTKLPSSLQSTGKCLLYCNGVLEPLYLCPNGARCATWFQDPTRFTGTMDAFVKIVRHEGT 120

Query: 69  TGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIM 128
             L+ G+ A ++   P  A+ F  +   K            Y  +  AG L+ + T  ++
Sbjct: 121 RTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGRALTSDLYAPM-VAGALARLGTVTVI 179

Query: 129 TPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFM 188
           +P E ++  LQ Q  S    Y     C +    + G R ++ G   T +RDVP S +Y+ 
Sbjct: 180 SPLELMRTKLQAQHVS----YRELGACVRTAVAQGGWRSLWLGWGPTALRDVPFSALYWF 235

Query: 189 TYEWLK---NIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGK- 244
            YE +K   N F P+     + S     VAGGI+G     + +P DV+K++ Q A     
Sbjct: 236 NYELVKSWLNGFRPK----DQTSVGMSFVAGGISGTVAAVLTLPFDVVKTQRQVALGAME 291

Query: 245 -------YPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKF 293
                  + +    +LR +  + G   L+ GF   +I+A P+ A     +E    F
Sbjct: 292 AVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIMISTYEFGKSF 347



 Score = 54.3 bits (129), Expect = 1e-07
 Identities = 45/191 (23%), Positives = 81/191 (42%), Gaps = 14/191 (7%)

Query: 14  LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYR 73
           ++AG    +  V V  PL+ ++ +LQ Q  S       Y     C R  + + G   L+ 
Sbjct: 165 MVAGALARLGTVTVISPLELMRTKLQAQHVS-------YRELGACVRTAVAQGGWRSLWL 217

Query: 74  GMAAPIIGVTPMFAVCFFGFGLGKK-LQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGE 132
           G     +   P  A+ +F + L K  L    P+D  S    F AG +SG     +  P +
Sbjct: 218 GWGPTALRDVPFSALYWFNYELVKSWLNGFRPKDQTSVGMSFVAGGISGTVAAVLTLPFD 277

Query: 133 RIKCLLQIQASSGESKYTGTLDC------AKKLYQEFGIRGIYKGTVLTLMRDVPASGMY 186
            +K   Q+   + E+     L         +++  E G +G++ G +  +++  P+  + 
Sbjct: 278 VVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTKGLFAGFLPRIIKAAPSCAIM 337

Query: 187 FMTYEWLKNIF 197
             TYE+ K+ F
Sbjct: 338 ISTYEFGKSFF 348



 Score = 35.0 bits (79), Expect = 0.081
 Identities = 25/99 (25%), Positives = 38/99 (38%), Gaps = 3/99 (3%)

Query: 13  NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPG---QPPMYSGTFDCFRKTLFREGIT 69
           + +AGG  G     +  P D VK + Q    ++      P     T+   R+     G  
Sbjct: 258 SFVAGGISGTVAAVLTLPFDVVKTQRQVALGAMEAVRVNPLHVDSTWLLLRRIRAESGTK 317

Query: 70  GLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVL 108
           GL+ G    II   P  A+    +  GK   Q+  +D L
Sbjct: 318 GLFAGFLPRIIKAAPSCAIMISTYEFGKSFFQRLNQDRL 356


>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
           sapiens]
          Length = 477

 Score = 94.0 bits (232), Expect = 1e-19
 Identities = 73/289 (25%), Positives = 128/289 (44%), Gaps = 12/289 (4%)

Query: 3   DQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKT 62
           D+ K     + LLAGG  G        PLD +K+ +Q       G        F  FR+ 
Sbjct: 187 DEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVH-----GSKSDKMNIFGGFRQM 241

Query: 63  LFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGV 122
           +   GI  L+RG    +I + P  AV F+ +   KKL  +  + + ++ + F +G ++G 
Sbjct: 242 VKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFER-FISGSMAGA 300

Query: 123 FTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPA 182
                + P E +K  L +  +    +Y+G  DCAKK+ +  G+   YKG V  L+  +P 
Sbjct: 301 TAQTFIYPMEVMKTRLAVGKTG---QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPY 357

Query: 183 SGMYFMTYEWLKNIFTPEGKRVSELSAPRILV-AGGIAGIFNWAVAIPPDVLKSRFQTAP 241
           +G+    YE LK+ +     + S      +L+  G ++       + P  ++++R Q   
Sbjct: 358 AGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQA 417

Query: 242 --PGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFE 288
              G        + R +I  EG+  LY+G     ++  PA    ++ +E
Sbjct: 418 MLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYE 466



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 45/197 (22%), Positives = 85/197 (43%), Gaps = 9/197 (4%)

Query: 1   MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFR 60
           + ++ + I   +  ++G   G       +P++ +K RL        G+   YSG +DC +
Sbjct: 279 LTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV------GKTGQYSGIYDCAK 332

Query: 61  KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQ-QKHPEDVLS--YPQLFAAG 117
           K L  EG+   Y+G    ++G+ P   +    + L K        +D ++     L   G
Sbjct: 333 KILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCG 392

Query: 118 MLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLM 177
            LS         P   ++  +Q QA    S     +   +++  + GI G+Y+G     M
Sbjct: 393 ALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFM 452

Query: 178 RDVPASGMYFMTYEWLK 194
           + +PA G+ ++ YE +K
Sbjct: 453 KVLPAVGISYVVYENMK 469


>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
           sapiens]
          Length = 458

 Score = 94.0 bits (232), Expect = 1e-19
 Identities = 73/289 (25%), Positives = 128/289 (44%), Gaps = 12/289 (4%)

Query: 3   DQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKT 62
           D+ K     + LLAGG  G        PLD +K+ +Q       G        F  FR+ 
Sbjct: 168 DEKKSGQWWRQLLAGGIAGAVSRTSTAPLDRLKIMMQVH-----GSKSDKMNIFGGFRQM 222

Query: 63  LFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGV 122
           +   GI  L+RG    +I + P  AV F+ +   KKL  +  + + ++ + F +G ++G 
Sbjct: 223 VKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFER-FISGSMAGA 281

Query: 123 FTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPA 182
                + P E +K  L +  +    +Y+G  DCAKK+ +  G+   YKG V  L+  +P 
Sbjct: 282 TAQTFIYPMEVMKTRLAVGKTG---QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPY 338

Query: 183 SGMYFMTYEWLKNIFTPEGKRVSELSAPRILV-AGGIAGIFNWAVAIPPDVLKSRFQTAP 241
           +G+    YE LK+ +     + S      +L+  G ++       + P  ++++R Q   
Sbjct: 339 AGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQA 398

Query: 242 --PGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFE 288
              G        + R +I  EG+  LY+G     ++  PA    ++ +E
Sbjct: 399 MLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYE 447



 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 45/197 (22%), Positives = 85/197 (43%), Gaps = 9/197 (4%)

Query: 1   MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFR 60
           + ++ + I   +  ++G   G       +P++ +K RL        G+   YSG +DC +
Sbjct: 260 LTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAV------GKTGQYSGIYDCAK 313

Query: 61  KTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQ-QKHPEDVLS--YPQLFAAG 117
           K L  EG+   Y+G    ++G+ P   +    + L K        +D ++     L   G
Sbjct: 314 KILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCG 373

Query: 118 MLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLM 177
            LS         P   ++  +Q QA    S     +   +++  + GI G+Y+G     M
Sbjct: 374 ALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFM 433

Query: 178 RDVPASGMYFMTYEWLK 194
           + +PA G+ ++ YE +K
Sbjct: 434 KVLPAVGISYVVYENMK 450


>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
          Length = 323

 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 95/303 (31%), Positives = 133/303 (43%), Gaps = 51/303 (16%)

Query: 1   MADQPKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFR 60
           MAD  K IS    L+ GG  G+  V    P+D  K RLQ Q     GQ  +Y+   DC  
Sbjct: 1   MAD--KQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQN---GQR-VYTSMSDCLI 54

Query: 61  KTLFREGITGLYRGMAAPIIGVTPMFAVC-----FFGFGLGKKLQQKHPEDVLSYPQLFA 115
           KT+  EG  G+YRG A  +  VTP  A+      FF   L K  Q+      L+  +   
Sbjct: 55  KTVRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQK------LTLLKEML 108

Query: 116 AGMLSGVFTTGIMTPGERIKCLLQ----------IQASSGESKYTG-------------- 151
           AG  +G     + TP E +K  LQ          I A+ G+    G              
Sbjct: 109 AGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRP 168

Query: 152 -TLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAP 210
                 + L +  GI G+YKG   TL+RDVP S +YF  +  L  +    G+  SE  +P
Sbjct: 169 TATQLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQL----GRPASEEKSP 224

Query: 211 RIL--VAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYP---NGFRDVLRELIRDEGVTSL 265
             +  +AG +AG        P DV+K+R Q+   G      +G  D  R+++R EG ++ 
Sbjct: 225 FYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAF 284

Query: 266 YKG 268
            KG
Sbjct: 285 LKG 287



 Score = 65.5 bits (158), Expect = 6e-11
 Identities = 55/204 (26%), Positives = 83/204 (40%), Gaps = 25/204 (12%)

Query: 11  LKNLLAGGFGGVCLVFVGHPLDTVKVRLQ-----------------------TQPPSLPG 47
           LK +LAG   G C V V  P++ +K++LQ                        QP     
Sbjct: 104 LKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAP 163

Query: 48  QPPMYSGTFDCFRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDV 107
             P  + T    R  L   GI GLY+G+ A ++   P   V F  F    +L +   E+ 
Sbjct: 164 AAPRPTAT-QLTRDLLRSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEK 222

Query: 108 LSYPQLFAAGMLSGVFTTGIMTPGERIKCLLQ-IQASSGESKYTGTLDCAKKLYQEFGIR 166
             +   F AG ++G      + P + +K  LQ +Q    E  Y+G LDCA+K+ +  G  
Sbjct: 223 SPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPS 282

Query: 167 GIYKGTVLTLMRDVPASGMYFMTY 190
              KG     +   P  G+  + Y
Sbjct: 283 AFLKGAYCRALVIAPLFGIAQVVY 306



 Score = 56.2 bits (134), Expect = 3e-08
 Identities = 48/204 (23%), Positives = 84/204 (41%), Gaps = 31/204 (15%)

Query: 108 LSYPQLFAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRG 167
           +S P     G ++G+     + P +  K  LQ Q  +G+  YT   DC  K  +  G  G
Sbjct: 6   ISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQ-QNGQRVYTSMSDCLIKTVRSEGYFG 64

Query: 168 IYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVA 227
           +Y+G  + L    P   +     ++ ++  + +G++++ L     ++AG  AG     V 
Sbjct: 65  MYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKE---MLAGCGAGTCQVIVT 121

Query: 228 IPPDVLKSRFQTA-----------------------PPGKYPNGFR----DVLRELIRDE 260
            P ++LK + Q A                       P  + P   R     + R+L+R  
Sbjct: 122 TPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRSR 181

Query: 261 GVTSLYKGFNAVMIRAFPANAACF 284
           G+  LYKG  A ++R  P +   F
Sbjct: 182 GIAGLYKGLGATLLRDVPFSVVYF 205



 Score = 42.7 bits (99), Expect = 4e-04
 Identities = 26/84 (30%), Positives = 37/84 (44%), Gaps = 2/84 (2%)

Query: 13  NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLY 72
           + LAG   G       +P D VK RLQ+    +      YSG  DC RK L  EG +   
Sbjct: 228 SFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGV--NEDTYSGILDCARKILRHEGPSAFL 285

Query: 73  RGMAAPIIGVTPMFAVCFFGFGLG 96
           +G     + + P+F +    + LG
Sbjct: 286 KGAYCRALVIAPLFGIAQVVYFLG 309


>gi|14150082 mitochondrial carrier protein MGC4399 [Homo sapiens]
          Length = 321

 Score = 91.7 bits (226), Expect = 7e-19
 Identities = 80/309 (25%), Positives = 132/309 (42%), Gaps = 29/309 (9%)

Query: 11  LKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPG--QPPMYSGT------------- 55
           L +L AGG GG        PL+ +K RLQ+   +L     P ++ GT             
Sbjct: 12  LLHLFAGGCGGTVGAIFTCPLEVIKTRLQSSRLALRTVYYPQVHLGTISGAGMVRPTSVT 71

Query: 56  ---FDCFRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQ 112
              F   +  L +EG   L+RG+   ++GV P  AV F  +   K+          +   
Sbjct: 72  PGLFQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACYSKAKEQFNGIFVPNSNIVH 131

Query: 113 LFAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGT 172
           +F+AG  + + T  +M P   +K  +Q++     SK   TL CA+ +YQ  GIRG Y+G 
Sbjct: 132 IFSAGSAAFI-TNSLMNPIWMVKTRMQLEQKVRGSKQMNTLQCARYVYQTEGIRGFYRGL 190

Query: 173 VLTLMRDVPASGMYFMTYEWLKNIF-------TPEGKRVSELSAPRILVAGGIAGIFNWA 225
             +    +  + + F  YE LK          +  G   +  S   ++ A  ++      
Sbjct: 191 TAS-YAGISETIICFAIYESLKKYLKEAPLASSANGTEKNSTSFFGLMAAAALSKGCASC 249

Query: 226 VAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFL 285
           +A P +V+++R +    G     F    R + R+EG  + Y+G  A +IR  P  A    
Sbjct: 250 IAYPHEVIRTRLR--EEGTKYKSFVQTARLVFREEGYLAFYRGLFAQLIRQIPNTAIVLS 307

Query: 286 GFEVAMKFL 294
            +E+ +  L
Sbjct: 308 TYELIVYLL 316


>gi|157388989 solute carrier family 25, member 36 isoform a [Homo
           sapiens]
          Length = 311

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 78/309 (25%), Positives = 133/309 (43%), Gaps = 29/309 (9%)

Query: 11  LKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYS-------------GTFD 57
           L +L AGG GG     +  PL+ VK RLQ+   +L       +             G   
Sbjct: 7   LVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLH 66

Query: 58  CFRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGK-KLQQKHPEDVLSYPQLFAA 116
           C +  L +EG   L+RG+   ++GV P  A+ F  +   K KL      D      + AA
Sbjct: 67  CLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMISAA 126

Query: 117 GMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTL 176
             ++G        P   IK  LQ+ A +   +  G  +C +K+YQ  G++G Y+G +   
Sbjct: 127 --MAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRG-MSAS 183

Query: 177 MRDVPASGMYFMTYEWLK---------NIFTPEGKRVSELS-APRILVAGGIAGIFNWAV 226
              +  + ++F+ YE +K         +    + + V E S    +++A   +      +
Sbjct: 184 YAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATTI 243

Query: 227 AIPPDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLG 286
           A P +V+++R +    G     F   L  L+++EG  SLY+G    ++R  P  A     
Sbjct: 244 AYPHEVVRTRLR--EEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMAT 301

Query: 287 FEVAMKFLN 295
           +E+ +  LN
Sbjct: 302 YELVVYLLN 310


>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
          Length = 304

 Score = 89.7 bits (221), Expect = 3e-18
 Identities = 77/263 (29%), Positives = 113/263 (42%), Gaps = 21/263 (7%)

Query: 11  LKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITG 70
           +K  L G   G C   +  PLD +K RLQT  PS  G   +  G      K +  E + G
Sbjct: 28  IKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRV--GMLAVLLKVVRTESLLG 85

Query: 71  LYRGMAAPIIGVTPMFAVCFFG--FGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIM 128
           L++GM+  I+   P   + +FG  + L +   + HP   L    L   G+ S       M
Sbjct: 86  LWKGMSPSIVRCVPGVGI-YFGTLYSLKQYFLRGHPPTALESVML---GVGSRSVAGVCM 141

Query: 129 TPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFM 188
           +P   IK   +    SG+  Y       + +Y   G RG++ G   TL+RD P SG+Y M
Sbjct: 142 SPITVIKTRYE----SGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYLM 197

Query: 189 TYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNG 248
            Y   KNI  P  +  + L        G  AGI    V  P DV+K+  Q      YP  
Sbjct: 198 FYNQTKNI-VPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQL-----YPLK 251

Query: 249 FR---DVLRELIRDEGVTSLYKG 268
           F+     +  + +D G+   ++G
Sbjct: 252 FQWIGQAVTLIFKDYGLRGFFQG 274



 Score = 47.0 bits (110), Expect = 2e-05
 Identities = 37/190 (19%), Positives = 77/190 (40%), Gaps = 20/190 (10%)

Query: 7   PISPLKNLLAG----GFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKT 62
           P + L++++ G       GVC+     P+  +K R ++           Y   +   R  
Sbjct: 120 PPTALESVMLGVGSRSVAGVCM----SPITVIKTRYESGKYG-------YESIYAALRSI 168

Query: 63  LFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQL-FAAGMLSG 121
              EG  GL+ G+ A ++   P   +    +   K +      D    P   F+ G+ +G
Sbjct: 169 YHSEGHRGLFSGLTATLLRDAPFSGIYLMFYNQTKNIVPHDQVDATLIPITNFSCGIFAG 228

Query: 122 VFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVP 181
           +  + +  P + IK  +Q+       K+         +++++G+RG ++G +   +R   
Sbjct: 229 ILASLVTQPADVIKTHMQLYPL----KFQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTL 284

Query: 182 ASGMYFMTYE 191
            + M +  YE
Sbjct: 285 MAAMAWTVYE 294


>gi|60460887 solute carrier family 25, member 42 [Homo sapiens]
          Length = 318

 Score = 89.4 bits (220), Expect = 4e-18
 Identities = 73/285 (25%), Positives = 126/285 (44%), Gaps = 16/285 (5%)

Query: 11  LKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITG 70
           L +LL G   G        PLD  K+  Q        +       F     T   EG   
Sbjct: 34  LSSLLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKE-----AFRVLYYTYLNEGFLS 88

Query: 71  LYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKH----PEDVLSYPQLFAAGMLSGVFTTG 126
           L+RG +A ++ V P  A+ F      K++   +     E +  +P+LFA G L+G     
Sbjct: 89  LWRGNSATMVRVVPYAAIQFSAHEEYKRILGSYYGFRGEALPPWPRLFA-GALAGTTAAS 147

Query: 127 IMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMY 186
           +  P + ++  + +   + +  Y+       ++ +E G++ +Y G + T++  +P +G+ 
Sbjct: 148 LTYPLDLVRARMAV---TPKEMYSNIFHVFIRISREEGLKTLYHGFMPTVLGVIPYAGLS 204

Query: 187 FMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYP 246
           F TYE LK++      R       R ++ G  AG+   + + P DV++ R QTA    YP
Sbjct: 205 FFTYETLKSLHREYSGRRQPYPFER-MIFGACAGLIGQSASYPLDVVRRRMQTAGVTGYP 263

Query: 247 N-GFRDVLRELIRDEG-VTSLYKGFNAVMIRAFPANAACFLGFEV 289
                  LR ++R+EG V  LYKG +   ++   A    F  F++
Sbjct: 264 RASIARTLRTIVREEGAVRGLYKGLSMNWVKGPIAVGISFTTFDL 308



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 45/188 (23%), Positives = 81/188 (43%), Gaps = 7/188 (3%)

Query: 8   ISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREG 67
           + P   L AG   G     + +PLD V+ R+   P        MYS  F  F +    EG
Sbjct: 129 LPPWPRLFAGALAGTTAASLTYPLDLVRARMAVTPKE------MYSNIFHVFIRISREEG 182

Query: 68  ITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYP-QLFAAGMLSGVFTTG 126
           +  LY G    ++GV P   + FF +   K L +++      YP +    G  +G+    
Sbjct: 183 LKTLYHGFMPTVLGVIPYAGLSFFTYETLKSLHREYSGRRQPYPFERMIFGACAGLIGQS 242

Query: 127 IMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMY 186
              P + ++  +Q    +G  + +        + +E  +RG+YKG  +  ++   A G+ 
Sbjct: 243 ASYPLDVVRRRMQTAGVTGYPRASIARTLRTIVREEGAVRGLYKGLSMNWVKGPIAVGIS 302

Query: 187 FMTYEWLK 194
           F T++ ++
Sbjct: 303 FTTFDLMQ 310



 Score = 30.8 bits (68), Expect = 1.5
 Identities = 24/82 (29%), Positives = 33/82 (40%)

Query: 213 LVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAV 272
           L+ G +AG        P D  K  FQ +           VL     +EG  SL++G +A 
Sbjct: 37  LLPGALAGALAKTAVAPLDRTKIIFQVSSKRFSAKEAFRVLYYTYLNEGFLSLWRGNSAT 96

Query: 273 MIRAFPANAACFLGFEVAMKFL 294
           M+R  P  A  F   E   + L
Sbjct: 97  MVRVVPYAAIQFSAHEEYKRIL 118


>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
          Length = 275

 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 77/277 (27%), Positives = 116/277 (41%), Gaps = 18/277 (6%)

Query: 4   QPKPISPLK--NLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPP---MYSGTFDC 58
           +P  + P      L  G        V  PLDT KVRLQ Q  +   Q      Y G    
Sbjct: 5   KPSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGT 64

Query: 59  FRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPE---DVLSYPQLFA 115
               +  EG    Y G+ A   G+    +      GL   ++Q +     D  S      
Sbjct: 65  ILTMVRTEGPCSPYNGLVA---GLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRIL 121

Query: 116 AGMLSGVFTTGIMTPGERIKCLLQIQASSGES----KYTGTLDCAKKLYQEFGIRGIYKG 171
           AG  +G        P + +K   Q     G S    KY+GT+D  + + +E G+RG++KG
Sbjct: 122 AGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKG 181

Query: 172 TVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPD 231
           T+  +MR+   +    +TY+ LK               P   V+   AG     VA P D
Sbjct: 182 TLPNIMRNAIVNCAEVVTYDILKEKLLDYHLLTDNF--PCHFVSAFGAGFCATVVASPVD 239

Query: 232 VLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKG 268
           V+K+R+  +PPG+Y +   D + +++  EG T+ YKG
Sbjct: 240 VVKTRYMNSPPGQYFSPL-DCMIKMVAQEGPTAFYKG 275



 Score = 55.1 bits (131), Expect = 8e-08
 Identities = 53/189 (28%), Positives = 81/189 (42%), Gaps = 16/189 (8%)

Query: 114 FAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESK------YTGTLDCAKKLYQEFGIRG 167
           F     +  F   +  P +  K  LQIQ  +   +      Y G L     + +  G   
Sbjct: 17  FLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCS 76

Query: 168 IYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVA 227
            Y G V  L R +  + +    Y+ +K ++TP+G   S L+  RIL AG   G      A
Sbjct: 77  PYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTT-RIL-AGCTTGAMAVTCA 134

Query: 228 IPPDVLKSRFQTA-------PPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPAN 280
            P DV+K RFQ +          KY +G  D  R + R+EGV  L+KG    ++R    N
Sbjct: 135 QPTDVVKVRFQASIHLGPSRSDRKY-SGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVN 193

Query: 281 AACFLGFEV 289
            A  + +++
Sbjct: 194 CAEVVTYDI 202


>gi|13899342 solute carrier [Homo sapiens]
          Length = 315

 Score = 88.6 bits (218), Expect = 6e-18
 Identities = 85/288 (29%), Positives = 120/288 (41%), Gaps = 37/288 (12%)

Query: 8   ISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREG 67
           +S    L+ GG  G+  V    P+D  K RLQ Q         MY G  DC  KT   EG
Sbjct: 6   LSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKA-----MYKGMIDCLMKTARAEG 60

Query: 68  ITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVL--SYPQLFAAGMLSGVFTT 125
             G+YRG A  +  VTP  A+        ++L     ED +  +      AG  +G+   
Sbjct: 61  FFGMYRGAAVNLTLVTPEKAIKLAANDFFRRLLM---EDGMQRNLKMEMLAGCGAGMCQV 117

Query: 126 GIMTPGERIKCLLQ-------------IQASSGESKYTGTLD---------CAKKLYQEF 163
            +  P E +K  LQ                S+  S  TG+            A +L +  
Sbjct: 118 VVTCPMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQ 177

Query: 164 GIRGIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFN 223
           G+ G+Y+G   TL+RD+P S +YF  +  L N+   E     + S     V+G +AG   
Sbjct: 178 GLAGLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNE--LAGKASFAHSFVSGCVAGSIA 235

Query: 224 WAVAIPPDVLKSRFQTAPPG---KYPNGFRDVLRELIRDEGVTSLYKG 268
                P DVLK+R QT   G      +G  D  R+L   EG ++  KG
Sbjct: 236 AVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKG 283



 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 53/199 (26%), Positives = 86/199 (43%), Gaps = 24/199 (12%)

Query: 14  LLAGGFGGVCLVFVGHPLDTVKVRLQTQ---------PPSLPGQPPMYS-GTFDCFRKT- 62
           +LAG   G+C V V  P++ +K++LQ             S P     Y+ G+    R+  
Sbjct: 106 MLAGCGAGMCQVVVTCPMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPS 165

Query: 63  --------LFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLF 114
                   L  +G+ GLYRG+ A ++   P   + F  F     L         S+   F
Sbjct: 166 ATLIAWELLRTQGLAGLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASFAHSF 225

Query: 115 AAGMLSGVFTTGIMTPGERIKCLLQ-IQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTV 173
            +G ++G      +TP + +K  +Q ++   GE  Y+G  DCA+KL+ + G     KG  
Sbjct: 226 VSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKGAG 285

Query: 174 LTLMRDVP----ASGMYFM 188
              +   P    A G+YF+
Sbjct: 286 CRALVIAPLFGIAQGVYFI 304



 Score = 50.4 bits (119), Expect = 2e-06
 Identities = 44/192 (22%), Positives = 77/192 (40%), Gaps = 29/192 (15%)

Query: 117 GMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTL 176
           G ++G+     + P +  K  LQ Q   G++ Y G +DC  K  +  G  G+Y+G  + L
Sbjct: 15  GGVAGLVGVTCVFPIDLAKTRLQNQ--HGKAMYKGMIDCLMKTARAEGFFGMYRGAAVNL 72

Query: 177 MRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSR 236
               P   +     ++ + +   +G    + +    ++AG  AG+    V  P ++LK +
Sbjct: 73  TLVTPEKAIKLAANDFFRRLLMEDGM---QRNLKMEMLAGCGAGMCQVVVTCPMEMLKIQ 129

Query: 237 FQTA---------------PPGKYPNGFRDVLR---------ELIRDEGVTSLYKGFNAV 272
            Q A                   Y  G     R         EL+R +G+  LY+G  A 
Sbjct: 130 LQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAGLYRGLGAT 189

Query: 273 MIRAFPANAACF 284
           ++R  P +   F
Sbjct: 190 LLRDIPFSIIYF 201



 Score = 43.5 bits (101), Expect = 2e-04
 Identities = 26/87 (29%), Positives = 42/87 (48%), Gaps = 8/87 (9%)

Query: 15  LAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYRG 74
           +AG    V +     PLD +K R+QT    L     MYSG  DC RK   +EG +   +G
Sbjct: 230 VAGSIAAVAVT----PLDVLKTRIQTLKKGLGED--MYSGITDCARKLWIQEGPSAFMKG 283

Query: 75  MAAPIIGVTPMFAVC--FFGFGLGKKL 99
                + + P+F +    +  G+G+++
Sbjct: 284 AGCRALVIAPLFGIAQGVYFIGIGERI 310



 Score = 36.6 bits (83), Expect = 0.028
 Identities = 20/63 (31%), Positives = 29/63 (46%)

Query: 206 ELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSL 265
           +LS    L+ GG+AG+       P D+ K+R Q         G  D L +  R EG   +
Sbjct: 5   DLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYKGMIDCLMKTARAEGFFGM 64

Query: 266 YKG 268
           Y+G
Sbjct: 65  YRG 67


>gi|13259541 uncoupling protein 2 [Homo sapiens]
          Length = 309

 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 76/290 (26%), Positives = 125/290 (43%), Gaps = 16/290 (5%)

Query: 7   PISPLKNLLAGGFGGVCLV-FVGHPLDTVKVRLQ----TQPPSLPGQPPMYSGTFDCFRK 61
           P + +K L AG     C+   +  PLDT KVRLQ    +Q P        Y G       
Sbjct: 11  PTATVKFLGAGT--AACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILT 68

Query: 62  TLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPE--DVLSYPQLFAAGML 119
            +  EG   LY G+ A   G+    +      GL   ++Q + +  +  S      AG  
Sbjct: 69  MVRTEGPRSLYNGLVA---GLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGST 125

Query: 120 SGVFTTGIMTPGERIKCLLQIQASSGESK-YTGTLDCAKKLYQEFGIRGIYKGTVLTLMR 178
           +G     +  P + +K   Q QA +G  + Y  T++  K + +E G RG++KGT   + R
Sbjct: 126 TGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVAR 185

Query: 179 DVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQ 238
           +   +    +TY+ +K+          +L  P    +   AG     +A P DV+K+R+ 
Sbjct: 186 NAIVNCAELVTYDLIKDALLKANLMTDDL--PCHFTSAFGAGFCTTVIASPVDVVKTRYM 243

Query: 239 TAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFE 288
            +  G+Y +     L  +++ EG  + YKGF    +R    N   F+ +E
Sbjct: 244 NSALGQYSSAGHCAL-TMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292



 Score = 59.7 bits (143), Expect = 3e-09
 Identities = 51/181 (28%), Positives = 78/181 (43%), Gaps = 5/181 (2%)

Query: 14  LLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGITGLYR 73
           LLAG   G   V V  P D VKVR Q Q  +  G+   Y  T + ++     EG  GL++
Sbjct: 120 LLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGR--RYQSTVNAYKTIAREEGFRGLWK 177

Query: 74  GMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIMTPGER 133
           G +  +     +       + L K    K        P  F +   +G  TT I +P + 
Sbjct: 178 GTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFCTTVIASPVDV 237

Query: 134 IKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGMYFMTYEWL 193
           +K       +S   +Y+    CA  + Q+ G R  YKG + + +R    + + F+TYE L
Sbjct: 238 VKTRYM---NSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQL 294

Query: 194 K 194
           K
Sbjct: 295 K 295


>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
          Length = 338

 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 70/299 (23%), Positives = 127/299 (42%), Gaps = 20/299 (6%)

Query: 5   PKPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLF 64
           P   S   ++ AG   G+    V +P+D+VK R+Q+  P    Q   Y+  +   +K + 
Sbjct: 40  PTSASVSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQ---YTSIYGALKKIMR 96

Query: 65  REGITGLYRGMAAPIIGVTPMFAVCFFGF-GLGKKLQQKHPEDVLSYPQLFAAGMLSGVF 123
            EG     RG+   I+G  P  A+ F  +  + + L         S+     AG ++ + 
Sbjct: 97  TEGFWRPLRGVNVMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLL 156

Query: 124 TTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPAS 183
              +M P E +K  LQ+      S++   + C + +++  G+   Y+     L  ++P  
Sbjct: 157 HDAVMNPAEVVKQRLQMY----NSQHRSAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQ 212

Query: 184 GMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQT---- 239
            ++F+TYE+L+    P        +    +++GG+AG    A   P DV K+   T    
Sbjct: 213 SIHFITYEFLQEQVNPH----RTYNPQSHIISGGLAGALAAAATTPLDVCKTLLNTQENV 268

Query: 240 ----APPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFL 294
               A      +G  +  R + +  G+   +KG  A +I   P+ A  +  +E    FL
Sbjct: 269 ALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFL 327



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 47/187 (25%), Positives = 87/187 (46%), Gaps = 17/187 (9%)

Query: 116 AGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLT 175
           AG ++G+    +M P + +K  +Q  +   +++YT      KK+ +  G     +G  + 
Sbjct: 51  AGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVM 110

Query: 176 LMRDVPASGMYFMTYEWLK----NIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPD 231
           +M   PA  MYF  YE +K    ++F  +G   S L+     +AG +A + + AV  P +
Sbjct: 111 IMGAGPAHAMYFACYENMKRTLNDVFHHQGN--SHLANG---IAGSMATLLHDAVMNPAE 165

Query: 232 VLKSRFQTAPPGKYPNGFRDV---LRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFE 288
           V+K R Q      Y +  R     +R + R EG+ + Y+ +   +    P  +  F+ +E
Sbjct: 166 VVKQRLQ-----MYNSQHRSAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYE 220

Query: 289 VAMKFLN 295
              + +N
Sbjct: 221 FLQEQVN 227



 Score = 51.6 bits (122), Expect = 8e-07
 Identities = 49/208 (23%), Positives = 82/208 (39%), Gaps = 18/208 (8%)

Query: 9   SPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGI 68
           S L N +AG    +    V +P + VK RLQ            +     C R     EG+
Sbjct: 142 SHLANGIAGSMATLLHDAVMNPAEVVKQRLQMYNSQ-------HRSAISCIRTVWRTEGL 194

Query: 69  TGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDVLSYPQLFAAGMLSGVFTTGIM 128
              YR     +    P  ++ F  +   +  +Q +P    +      +G L+G       
Sbjct: 195 GAFYRSYTTQLTMNIPFQSIHFITYEFLQ--EQVNPHRTYNPQSHIISGGLAGALAAAAT 252

Query: 129 TPGERIKCLLQIQASSGES------KYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPA 182
           TP +  K LL  Q +   S      + +G  +  + +YQ  G+ G +KG    ++  +P+
Sbjct: 253 TPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPS 312

Query: 183 SGMYFMTYEWLKNIFTPEGKRVSELSAP 210
           + + +  YE+ K   T   KR  E  AP
Sbjct: 313 TAISWSVYEFFKYFLT---KRQLENRAP 337


>gi|157388991 solute carrier family 25, member 36 isoform b [Homo
           sapiens]
          Length = 310

 Score = 86.3 bits (212), Expect = 3e-17
 Identities = 77/308 (25%), Positives = 127/308 (41%), Gaps = 28/308 (9%)

Query: 11  LKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYS-------------GTFD 57
           L +L AGG GG     +  PL+ VK RLQ+   +L       +             G   
Sbjct: 7   LVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLH 66

Query: 58  CFRKTLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGK-KLQQKHPEDVLSYPQLFAA 116
           C +  L +EG   L+RG+   ++GV P  A+ F  +   K KL      D      + AA
Sbjct: 67  CLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQVHMISAA 126

Query: 117 GMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTL 176
             ++G        P   IK  LQ+ A +   +  G  +C +K+YQ  G++G Y+G +   
Sbjct: 127 --MAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRG-MSAS 183

Query: 177 MRDVPASGMYFMTYEWLK-NIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIP------ 229
              +  + ++F+ YE +K  +   +     E     +  A    G+   A          
Sbjct: 184 YAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATTI 243

Query: 230 --PDVLKSRFQTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGF 287
             P V+++R +    G     F   L  L+++EG  SLY+G    ++R  P  A     +
Sbjct: 244 AYPHVVRTRLR--EEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMATY 301

Query: 288 EVAMKFLN 295
           E+ +  LN
Sbjct: 302 ELVVYLLN 309


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.142    0.444 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,628,955
Number of Sequences: 37866
Number of extensions: 590749
Number of successful extensions: 1810
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1159
Number of HSP's gapped (non-prelim): 209
length of query: 301
length of database: 18,247,518
effective HSP length: 102
effective length of query: 199
effective length of database: 14,385,186
effective search space: 2862652014
effective search space used: 2862652014
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.