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Search of human proteins with 4557257
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557257 adenylate cyclase 8 [Homo sapiens]
(1251 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557257 adenylate cyclase 8 [Homo sapiens] 2500 0.0
gi|34486092 adenylate cyclase 5 [Homo sapiens] 772 0.0
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 749 0.0
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 736 0.0
gi|148536830 adenylate cyclase 3 [Homo sapiens] 677 0.0
gi|31083193 adenylate cyclase 1 [Homo sapiens] 660 0.0
gi|115387102 adenylate cyclase 2 [Homo sapiens] 648 0.0
gi|4557255 adenylate cyclase 7 [Homo sapiens] 595 e-170
gi|24497587 adenylate cyclase 4 [Homo sapiens] 595 e-170
gi|50959205 adenylate cyclase 9 [Homo sapiens] 221 3e-57
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 124 6e-28
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 118 4e-26
gi|134152694 guanylate cyclase 2F [Homo sapiens] 115 3e-25
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 110 8e-24
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 110 1e-23
gi|222080083 guanylate cyclase 2C [Homo sapiens] 104 6e-22
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 103 1e-21
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 101 4e-21
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 101 4e-21
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 101 4e-21
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 101 4e-21
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 101 4e-21
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 101 4e-21
gi|25777671 protein phosphatase 1, regulatory subunit 10 [Homo s... 40 0.014
gi|55956910 meningioma 1 [Homo sapiens] 39 0.031
gi|4504733 insulin receptor substrate 4 [Homo sapiens] 39 0.041
gi|55741655 anoctamin 8 [Homo sapiens] 37 0.090
gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2 ... 37 0.090
gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1 ... 37 0.090
gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3 ... 37 0.090
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 2500 bits (6479), Expect = 0.0
Identities = 1251/1251 (100%), Positives = 1251/1251 (100%)
Query: 1 MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGS 60
MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGS
Sbjct: 1 MELSDVRCLTGSEELYTIHPTPPAGDGRSASRPQRLLWQTAVRHITEQRFIHGHRGGSGS 60
Query: 61 GSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASG 120
GSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASG
Sbjct: 61 GSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASG 120
Query: 121 SGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRK 180
SGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRK
Sbjct: 121 SGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRK 180
Query: 181 SEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHT 240
SEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHT
Sbjct: 181 SEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHT 240
Query: 241 YLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTS 300
YLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTS
Sbjct: 241 YLQYSGVVTWVAMTTQILAAGLGYGLLGDGIGYVLFTLFATYSMLPLPLTWAILAGLGTS 300
Query: 301 LLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEAR 360
LLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEAR
Sbjct: 301 LLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEAR 360
Query: 361 LRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV 420
LRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV
Sbjct: 361 LRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADV 420
Query: 421 KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAH 480
KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAH
Sbjct: 421 KGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAH 480
Query: 481 CCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKL 540
CCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKL
Sbjct: 481 CCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKL 540
Query: 541 ESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPED 600
ESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPED
Sbjct: 541 ESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPED 600
Query: 601 IVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHV 660
IVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHV
Sbjct: 601 IVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHV 660
Query: 661 QSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAF 720
QSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAF
Sbjct: 661 QSGPEEINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAF 720
Query: 721 IVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINE 780
IVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINE
Sbjct: 721 IVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTCCWINE 780
Query: 781 TYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG 840
TYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG
Sbjct: 781 TYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTG 840
Query: 841 VLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEV 900
VLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEV
Sbjct: 841 VLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEV 900
Query: 901 SLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVA 960
SLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVA
Sbjct: 901 SLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVA 960
Query: 961 RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDE 1020
RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDE
Sbjct: 961 RHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDE 1020
Query: 1021 LLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKH 1080
LLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKH
Sbjct: 1021 LLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKH 1080
Query: 1081 SFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLIL 1140
SFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLIL
Sbjct: 1081 SFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLIL 1140
Query: 1141 KDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLV 1200
KDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLV
Sbjct: 1141 KDQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNPFILPPRRLPGQYSLAAVVLGLV 1200
Query: 1201 QSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP 1251
QSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP
Sbjct: 1201 QSLNRQRQKQLLNENNNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDKSDLP 1251
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 772 bits (1994), Expect = 0.0
Identities = 463/1162 (39%), Positives = 668/1162 (57%), Gaps = 74/1162 (6%)
Query: 59 GSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSA 118
G+ SGGS +A GGG + A +G + + S+ G G + +G+
Sbjct: 121 GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAA--DELEAGAV 178
Query: 119 SGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQR 178
G G GD G + + L+ G ++ F S LERLYQRYF
Sbjct: 179 EGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLN 238
Query: 179 RKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTS 238
+ S ++ + VL L +L H A PL+ L VI + V+
Sbjct: 239 QSSLTMLMAVLVLVCLVMLAFH-----AARPPLQLPYLAVLAAAVGVILIMAVLCNRAAF 293
Query: 239 HTYLQYSGVVTWVAMTTQILAAGLGYGL-----LGDGIGYVLFTLFATYSMLPLPLTWAI 293
H + G+ + + + +G L +GI + +F ++ Y++LP+ + A+
Sbjct: 294 HQ--DHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAV 351
Query: 294 LAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLET 353
L+G+ S L + + + + Q+V+ ++F C N G+ Y ++ +QRQAF ET
Sbjct: 352 LSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQET 411
Query: 354 RRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENV 413
R C++ARL + ENQ+QERL+LSVLPR V +EM D+ +++ + FH+IYI +++NV
Sbjct: 412 RECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMM---FHKIYIQKHDNV 468
Query: 414 SILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPE 473
SILFAD++GFT+L++ +AQELV LNELFARFD+LA E+HCLRIKILGDCYYCVSGLPE
Sbjct: 469 SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPE 528
Query: 474 PRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWD 533
R DHAHCCVEMG+ MI+ I VR T +V+MR+GIHSG V CGVLGLRKWQFDVWS D
Sbjct: 529 ARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSND 588
Query: 534 VDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDS 593
V +AN +E+GG GRIHI+KATL+ LNGDY VE G G ERN +L++H+IET+LI +
Sbjct: 589 VTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQK 648
Query: 594 LLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNH 653
I K + +R + W E PF N +G + R +
Sbjct: 649 RKEEKAMIAK----MNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDK 704
Query: 654 LAQALHVQSGPE-EINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVF 712
AQ + PE E+++ + ID RS D+LR EH++ F L F++ LE KYS+ D+ F
Sbjct: 705 NAQE---SANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRF 761
Query: 713 KSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILR 772
+ + CA +V LFI +Q + + ++ + ++L + + K P L+
Sbjct: 762 GAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQ 821
Query: 773 KTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDI--- 829
I + + ++ +I + FL A +N+ C+ + N SA +
Sbjct: 822 TLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHV 881
Query: 830 ----------------------CSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIA 867
C++PEYF ++ +L+++ C+VFL+++ + KL ++L +
Sbjct: 882 AESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIEL 941
Query: 868 IYALLTETVYAGLFLRYDNL-NHSGEDF--------------LGTKEVSLLLMAMFLLAV 912
IY L+ E LF D L + DF + K V+ +++++F+LA+
Sbjct: 942 IYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLAL 1001
Query: 913 FYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEE 972
+ H QQ+E TARLDFLW++QA EE EM+EL+ +N +L NILP VA HFL ++R N+E
Sbjct: 1002 YLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDE 1061
Query: 973 LYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEK 1032
LY QS + V VMFASI F++FY + E NN+GVECLRLLNEIIADFDE++ EDRF+ +EK
Sbjct: 1062 LYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEK 1121
Query: 1033 IKTIGSTYMAVSGLSPEKQQCEDKWG--HLCALADFSLALTESIQEINKHSFNNFELRIG 1090
IKTIGSTYMA SGL+ DK G H+ ALADF++ L + ++ IN+HSFNNF+++IG
Sbjct: 1122 IKTIGSTYMAASGLN---DSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIG 1178
Query: 1091 ISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYR 1150
++ G VVAGVIGA+KPQYDIWG TVN+ASRMDSTGV RIQV + Y +L + + R
Sbjct: 1179 LNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECR 1238
Query: 1151 GEIYVKGISEQEGKIKTYFLLG 1172
G + VKG +G++ TYFL G
Sbjct: 1239 GVVKVKG----KGEMMTYFLNG 1256
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 749 bits (1935), Expect = 0.0
Identities = 445/1078 (41%), Positives = 636/1078 (58%), Gaps = 76/1078 (7%)
Query: 144 NGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSL 203
+G +R ++ F+S LERLYQRYF + S ++ + VL LL H
Sbjct: 114 SGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFH--- 170
Query: 204 ASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLG 263
+AP P + + + +VV + H++ Q S V + + A +G
Sbjct: 171 -AAPARPQPAYVALLACAAALFVGLMVVCNR----HSFRQDSMWVVSYVVLGILAAVQVG 225
Query: 264 YGLLGD------GIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVIS 317
L D G+ +F ++ Y++LP+ + A+L+GLG S L +IL + R
Sbjct: 226 GALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFL 285
Query: 318 INQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSV 377
Q+ A +LF+C N GI Y ++ +QRQAF ETR ++ARL L+ EN++QERL+LSV
Sbjct: 286 WKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSV 345
Query: 378 LPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVR 437
LP+ V +EM D+ +++ + FH+IYI +++NVSILFAD++GFT+L++ +AQELV
Sbjct: 346 LPQHVAMEMKEDINTKKEDMM---FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVM 402
Query: 438 MLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVR 497
LNELFARFD+LA E+HCLRIKILGDCYYCVSGLPE R DHAHCCVEMG+ MI+ I VR
Sbjct: 403 TLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVR 462
Query: 498 SRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLD 557
T +V+MR+GIHSG V CGVLGLRKWQFDVWS DV +AN +E+GG GRIHI++ATL
Sbjct: 463 EVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQ 522
Query: 558 CLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGAT 617
LNGDY VE G G ERN +L++ +IET+LI L + +E + + + A
Sbjct: 523 YLNGDYEVEPGRGGERNAYLKEQHIETFLI-------LGASQKRKEEKAMLAKLQRTRAN 575
Query: 618 FTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDL 677
EG +P D + A + I+ + +E+++ + ID
Sbjct: 576 SMEGLMPRWVP-DRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDA 634
Query: 678 RSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSR 737
RS D+LR++H++ F L F+ LE KYS+ D F + + CA +V FI IQ L+
Sbjct: 635 RSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHS 694
Query: 738 VMPMTIQFSILIMLHSALVLITTAEDYKC---LPLILRKTCCWINETYLARNVIIFASIL 794
+ + I SI ++L L+ + Y C P L++ I + + S+L
Sbjct: 695 TLMLGIYASIFLLL---LITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVL 751
Query: 795 INFLGAILNILWCDFD--KSIPLKNLTFNSSAVFT---------------------DICS 831
+ F AI N+ C+ +S + L + + CS
Sbjct: 752 LVFTSAIANMFTCNHTPIRSCAARMLNLTPADITACHLQQLNYSLGLDAPLCEGTMPTCS 811
Query: 832 YPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIY-ALLTETVYAGLFLRYD----- 885
+PEYF+ +L+++ +VFL ++S+ KLA++ ++ IY LL A +F YD
Sbjct: 812 FPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGV 871
Query: 886 -NLNHSGEDFLG----------TKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAK 934
L S E F G K ++ +++ +F LA++ H QQ+E TARLDFLW++QA
Sbjct: 872 HGLASSNETFDGLDCPAAGRVALKYMTPVILLVFALALYLHAQQVESTARLDFLWKLQAT 931
Query: 935 EEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADF 994
E EM+EL+ +N +L NILP VA HFL ++R N+ELY QS + V VMFASI F++F
Sbjct: 932 GEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF 991
Query: 995 YSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCE 1054
Y + E NN+GVECLRLLNEIIADFDE++ E+RF+ +EKIKTIGSTYMA SGL+
Sbjct: 992 YVELEANNEGVECLRLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQV 1051
Query: 1055 DKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKT 1114
+ H+ ALAD+++ L E ++ IN+HSFNNF+++IG++ G VVAGVIGA+KPQYDIWG T
Sbjct: 1052 GR-SHITALADYAMRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNT 1110
Query: 1115 VNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLG 1172
VN++SRMDSTGV RIQV + Y +L +G+ + RG + VKG +G++ TYFL G
Sbjct: 1111 VNVSSRMDSTGVPDRIQVTTDLYQVLAAKGYQLECRGVVKVKG----KGEMTTYFLNG 1164
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 736 bits (1901), Expect = 0.0
Identities = 438/1055 (41%), Positives = 623/1055 (59%), Gaps = 83/1055 (7%)
Query: 144 NGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSL 203
+G +R ++ F+S LERLYQRYF + S ++ + VL LL H
Sbjct: 114 SGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFH--- 170
Query: 204 ASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLG 263
+AP P + + + +VV + H++ Q S V + + A +G
Sbjct: 171 -AAPARPQPAYVALLACAAALFVGLMVVCNR----HSFRQDSMWVVSYVVLGILAAVQVG 225
Query: 264 YGLLGD------GIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVIPRLAVIS 317
L D G+ +F ++ Y++LP+ + A+L+GLG S L +IL + R
Sbjct: 226 GALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFL 285
Query: 318 INQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSV 377
Q+ A +LF+C N GI Y ++ +QRQAF ETR ++ARL L+ EN++QERL+LSV
Sbjct: 286 WKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSV 345
Query: 378 LPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVR 437
LP+ V +EM D+ +++ + FH+IYI +++NVSILFAD++GFT+L++ +AQELV
Sbjct: 346 LPQHVAMEMKEDINTKKEDMM---FHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVM 402
Query: 438 MLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVR 497
LNELFARFD+LA E+HCLRIKILGDCYYCVSGLPE R DHAHCCVEMG+ MI+ I VR
Sbjct: 403 TLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGVDMIEAISLVR 462
Query: 498 SRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLD 557
T +V+MR+GIHSG V CGVLGLRKWQFDVWS DV +AN +E+GG GRIHI++ATL
Sbjct: 463 EVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQ 522
Query: 558 CLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGAT 617
LNGDY VE G G ERN +L++ +IET+LI L + +E + + + A
Sbjct: 523 YLNGDYEVEPGRGGERNAYLKEQHIETFLI-------LGASQKRKEEKAMLAKLQRTRAN 575
Query: 618 FTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHTIDL 677
EG +P D + A + I+ + +E+++ + ID
Sbjct: 576 SMEGLMPRWVP-DRAFSRTKDSKAFRQMGIDDSSKDNRGTQDALNPEDEVDEFLSRAIDA 634
Query: 678 RSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSR 737
RS D+LR++H++ F L F+ LE KYS+ D F + + CA +V FI IQ L+
Sbjct: 635 RSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDPRFGAYVACALLVFCFICFIQLLIFPHS 694
Query: 738 VMPMTIQFSILIMLHSALVLITTAEDYKC---LPLILRKTCCWINETYLARNVIIFASIL 794
+ + I SI ++L L+ + Y C P L++ I + + S+L
Sbjct: 695 TLMLGIYASIFLLL---LITVLICAVYSCGSLFPKALQRLSRSIVRSRAHSTAVGIFSVL 751
Query: 795 INFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLN 854
+ F AI N+ YF+ +L+++ +VFL ++
Sbjct: 752 LVFTSAIANM------------------------------YFIGNMLLSLLASSVFLHIS 781
Query: 855 SVLKLAVLLIMIAIY-ALLTETVYAGLFLRYD------NLNHSGEDFLG----------T 897
S+ KLA++ ++ IY LL A +F YD L S E F G
Sbjct: 782 SIGKLAMIFVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVAL 841
Query: 898 KEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPS 957
K ++ +++ +F LA++ H QQ+E TARLDFLW++QA E EM+EL+ +N +L NILP
Sbjct: 842 KYMTPVILLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPK 901
Query: 958 HVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIAD 1017
VA HFL ++R N+ELY QS + V VMFASI F++FY + E NN+GVECLRLLNEIIAD
Sbjct: 902 DVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIAD 961
Query: 1018 FDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEI 1077
FDE++ E+RF+ +EKIKTIGSTYMA SGL+ + H+ ALAD+++ L E ++ I
Sbjct: 962 FDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR-SHITALADYAMRLMEQMKHI 1020
Query: 1078 NKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETY 1137
N+HSFNNF+++IG++ G VVAGVIGA+KPQYDIWG TVN++SRMDSTGV RIQV + Y
Sbjct: 1021 NEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLY 1080
Query: 1138 LILKDQGFAFDYRGEIYVKGISEQEGKIKTYFLLG 1172
+L +G+ + RG + VKG +G++ TYFL G
Sbjct: 1081 QVLAAKGYQLECRGVVKVKG----KGEMTTYFLNG 1111
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 677 bits (1746), Expect = 0.0
Identities = 407/1090 (37%), Positives = 633/1090 (58%), Gaps = 93/1090 (8%)
Query: 157 LRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILL 216
+R +F LE LYQ YF QR ++ +V+ V L ++V+ + S+ D L + +
Sbjct: 53 MRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSS--DKLASLAV 110
Query: 217 GFFTGIEVVICALVVVRK----DTTSHTYLQYSGVVTWVAMTTQILA-AGLGYG---LLG 268
G+ + I V+ +K D + L Y V W+ +T QI + GL +
Sbjct: 111 AGI-GLVLDIILFVLCKKGLLPDRVTRRVLPY---VLWLLITAQIFSYLGLNFARAHAAS 166
Query: 269 DGIGYVLFTLFATYSMLPLPLTWAILAGLGTSLLQ-VILQVVIPRL------AVISINQV 321
D +G+ +F +F+ + LPL L+ ++ + + ++ ++L V + + + + ++
Sbjct: 167 DTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREI 226
Query: 322 VAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRF 381
+A L++C GI Y++DR R+AFLE R+ +E ++ LE ++Q+QE L+LS+LP+
Sbjct: 227 LANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKH 286
Query: 382 VVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNE 441
V EM+ DM E + Q QF+ +Y++R+ENVSILFAD+ GFT LS+ SAQELV++LNE
Sbjct: 287 VADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNE 346
Query: 442 LFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTK 501
LFARFD+LA ++H LRIKILGDCYYC+ GLP+ R+DHA C + MGL+M++ I YVR +TK
Sbjct: 347 LFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTK 406
Query: 502 HDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNG 561
VDMR+G+H+G+VL GVLG ++WQ+DVWS DV +ANK+E+GGIPGR+HIS++T+DCL G
Sbjct: 407 TGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKG 466
Query: 562 DYNVEEGHGKERNEFLRKHNIETYLI--KQPEDSLL---------SLPEDIVKESVSSS- 609
+++VE G G R ++L + IETYLI +PE +LP S SSS
Sbjct: 467 EFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSP 526
Query: 610 ----DRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPE 665
+ +G+ + GS S E P + N R + L + + +
Sbjct: 527 ALIETKEPNGSAHSSGSTS-EKPEEQDAQADNPSFPNPRRRLR-LQDLADRVVDASEDEH 584
Query: 666 EINKRI-EHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLL 724
E+N+ + E ++ S +++ + S+ F D +E +YS +++ + C+ +VLL
Sbjct: 585 ELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLL 644
Query: 725 FITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDY-KCLPLILRKTCCWINETYL 783
TA+ +L +M + F + +L L + + A + + P L WI+ T
Sbjct: 645 -CTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRW 703
Query: 784 ARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVF-----TDICSYPEYFVF 838
ARN +I I + ++++L C L+ T S+A P+Y+ +
Sbjct: 704 ARNTWAMLAIFILVMANVVDMLSC-------LQYYTGPSNATAGMETEGSCLENPKYYNY 756
Query: 839 TGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGED----- 893
VL+++ + ++++ ++KL ++L++ A + + +F YD+ D
Sbjct: 757 VAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVA 816
Query: 894 ----------FLGTKEVSL--------LLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKE 935
GT + L +++ + +L+ +Y + +E AR FLW+++ +
Sbjct: 817 LEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHD 876
Query: 936 EINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFY 995
+ + E+R NE ++ N+LP HVARHFL + +EELYSQ+YD +GVMFAS+P FADFY
Sbjct: 877 QKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFY 936
Query: 996 SQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSP------- 1048
++ +NN G+ECLR LNEII+DFD LL +F+ I KIKTIGSTYMA SG++P
Sbjct: 937 TEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGF 996
Query: 1049 -----EKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGA 1103
E + ++W HL LADF+LA+ +++ IN SFNNF LRIG++ G V+AGVIGA
Sbjct: 997 ASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGA 1056
Query: 1104 KKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEG 1163
+KP YDIWG TVN+ASRM+STGV G IQV EET +IL++ GF F RG I+VKG +G
Sbjct: 1057 RKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKG----KG 1112
Query: 1164 KIKTYFLLGR 1173
++ T+FL GR
Sbjct: 1113 ELLTFFLKGR 1122
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 660 bits (1703), Expect = 0.0
Identities = 427/1102 (38%), Positives = 610/1102 (55%), Gaps = 87/1102 (7%)
Query: 116 GSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFL 175
G G GG G+ G S RG+ F +LE L++ Y L
Sbjct: 7 GGGGGGGGAGEPGGAERAAGTSRR----------RGL--RACDEEFACPELEALFRGYTL 54
Query: 176 GQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKD 235
R + + L VL+ L + L AP P G+ G V+ AL+VV
Sbjct: 55 --RLEQAATLKALAVLSLLAGALALAELLGAP-GPAPGLAKGSHPVHCVLFLALLVVTNV 111
Query: 236 TTSHT-YLQYSGVV------TWVAMTTQILAAGLGYGLLG---------DGIGYVLFTLF 279
+ LQ G + T+ + G G G G+ +L F
Sbjct: 112 RSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTF 171
Query: 280 ATYSMLPLPLTWAILAGLGTSLLQVILQV-VIPRLAVISINQVVAQAVLFMCMNTAGIFI 338
+Y++LP+ AI GL + +++ ++P + A A+LF+ +N G+F+
Sbjct: 172 VSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFV 231
Query: 339 SYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHL 398
L++R+QR+AFL+ R C+E RLRLE EN++QERL++S+LPR V +EM D +
Sbjct: 232 RILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERI- 290
Query: 399 QHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRI 458
FH+IYI R++NVSILFAD+ GFT L++ +AQELV++LNELF +FD LA E+HC RI
Sbjct: 291 ---FHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRI 347
Query: 459 KILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCG 518
KILGDCYYCVSGL +P+ DHAHCCVEMGL MI TI V T+ D++MR+G+H+G VLCG
Sbjct: 348 KILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCG 407
Query: 519 VLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLR 578
VLGLRKWQ+DVWS DV +AN +E+ G+PG++HI+K TL CLNGDY VE G+G ERN FL+
Sbjct: 408 VLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLK 467
Query: 579 KHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATF-------TEGSWSPELPFDN 631
HNIET+ I P P I+ + + + + + E+PF N
Sbjct: 468 THNIETFFI-VPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSN 526
Query: 632 IVG-KQNTLAALTRNSINLLPNHLAQALHV--QSGPEEINKRIEHTIDLRSGDKLRREHI 688
++ + + R + L N + + +V + +N+ I ++ R +L +
Sbjct: 527 VMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQ-TELEMADL 585
Query: 689 KPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIV-LLFITAIQSLLPSSRVMPMTIQFSI 747
F+L +K E KY Q++DE F S +V I+ LF + P S V+ + + F I
Sbjct: 586 NFFTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCI 645
Query: 748 LIMLHSALVL-ITTAEDYK-CLPLILRKTCCWINETYLARNVIIFASILINFL--GAILN 803
++ L L IT + + CL + +R C IF +LI + G ++
Sbjct: 646 CFLVACVLYLHITRVQCFPGCLTIQIRTVLC------------IFIVVLIYSVAQGCVVG 693
Query: 804 IL-WCDFDKSIPLKNLTFNSS-----AVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVL 857
L W K P +L SS A+ T C + + ++ + A+F R++S+
Sbjct: 694 CLPWAWSSK--PNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLP 751
Query: 858 KLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQ 917
K+ +L + Y L+ E G G ++ + +F A+ H +
Sbjct: 752 KMILLSGLTTSYILVLEL--------SGYTRTGGGAVSGRSYEPIVAILLFSCALALHAR 803
Query: 918 QLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQS 977
Q++ RLD+LW QA+EE +M++++ N +L N+LP+HVA+HFL + N +LY QS
Sbjct: 804 QVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQS 863
Query: 978 YDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIG 1037
Y VGVMFASIP F DFY + + NN GVECLRLLNEIIADFDEL+ +D ++DIEKIKTIG
Sbjct: 864 YSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIG 923
Query: 1038 STYMAVSGLSPEKQQCEDK--WGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGS 1095
STYMA GL+P K HL LADF++ + + + EIN S+N+F LR+GI+ G
Sbjct: 924 STYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGP 983
Query: 1096 VVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYV 1155
VVAGVIGA++PQYDIWG TVN+ASRMDSTGV GRIQV EE + +L+ + F RG++ V
Sbjct: 984 VVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSV 1043
Query: 1156 KGISEQEGKIKTYFLLGRVQPN 1177
KG +G++ TYFL GR N
Sbjct: 1044 KG----KGEMLTYFLEGRTDGN 1061
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 648 bits (1671), Expect = 0.0
Identities = 395/1066 (37%), Positives = 614/1066 (57%), Gaps = 76/1066 (7%)
Query: 164 RDLERLYQRYFLGQRRKSEVVMNVLDVLTK-LTLLVLHLSLASAPMDPLKGIL-----LG 217
R + LY+ Y+ ++ +V +L V+ L LL + +L D + ++ L
Sbjct: 28 RSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALA 87
Query: 218 FFTGIEVVICALVVVRKDTTSHTYLQYSGVVTWVAMTTQILAAGLGYGLLG------DGI 271
F I +++C V +K L+ +V W+ + +A G + G D +
Sbjct: 88 IFFAIFILVCIESVFKK------LLRLFSLVIWICL----VAMGYLFMCFGGTVSPWDQV 137
Query: 272 GYVLFTLFATYSMLPLPLTWAILAGLGTSLLQVILQVVI----PRLAVISINQVVAQAVL 327
+ LF +F Y+MLP + AI+A + TS I+ V P + Q++A ++
Sbjct: 138 SFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVII 197
Query: 328 FMCMNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEM- 386
F+C N AG + +L + A +Q + +T C+++R++LE E ++QERL+LS+LP + +EM
Sbjct: 198 FICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMK 257
Query: 387 ---INDMTNVEDEHLQH--QFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNE 441
I + + +++ FH +Y+ R+ NVSIL+AD+ GFT L++ S ELV MLNE
Sbjct: 258 AEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNE 317
Query: 442 LFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTK 501
LF +FD++A E+ C+RIKILGDCYYCVSGLP +HA CV+MGL M + I+ VR T
Sbjct: 318 LFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATG 377
Query: 502 HDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNG 561
D++MR+G+HSG+VLCGV+GL+KWQ+DVWS DV +AN +E+GG+PGR+HIS TL+ LNG
Sbjct: 378 VDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNG 437
Query: 562 DYNVEEGHGKERNEFLRKHNIETYLIKQPEDSLLSLPEDIVKESVS---SSDRRNSGATF 618
Y VEEG G R+ +L++H ++TY + P+ S P+ + + + + R + T
Sbjct: 438 AYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRS-PQHLFRPRHTLDGAKMRASVRMTR 496
Query: 619 TEGSWSPELPFDNIVGKQNTLAALTRNSINLLP----NHLAQALHVQSG----PEEINKR 670
SW PF ++ + + + S +P N + L +S EE+N+R
Sbjct: 497 YLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNER 556
Query: 671 IEHTIDLRSGDK--LRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITA 728
+ ID + K L+ E I+ SL+F + LE +Y FK + CA ++ I
Sbjct: 557 MIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFI 616
Query: 729 IQSL-LPSSRVMPMTIQFSILIMLHSALVLITTAEDY-----KCLPL---ILRKTCCWIN 779
+Q L LP + V + I F +L + ++ + A K PL +L+ + N
Sbjct: 617 VQILVLPKTSV--LGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIAN 674
Query: 780 ETYLARNVIIFASILINFLGAILNILWCDFDKSIP----LKNLTFNSSAVFTDICS---- 831
+ ++ I + +I + D +++IP N +F++S I
Sbjct: 675 RPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNL 734
Query: 832 -YPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDN-LNH 889
+ YF+++ +L +++C+VFLR+N LK+ ++++ + Y + +A + Y L
Sbjct: 735 FFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFE 794
Query: 890 SGEDFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNEN 949
+ K + + +++F + + G+Q EY RLDFLW+ + K+E E++ + N
Sbjct: 795 RPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRV 854
Query: 950 MLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLR 1009
+L N+LP+HVA HFL + NEELY QSYD V VMFASIP F +FY+++++N +G+ECLR
Sbjct: 855 LLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLR 914
Query: 1010 LLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLS-----PEKQQCEDKWGHLCALA 1064
LLNEIIADFD+LL + +F +EKIKTIGSTYMA +GLS Q+ E ++ H+ +
Sbjct: 915 LLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMV 974
Query: 1065 DFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDST 1124
+F+ AL + INKHSFN+F+LR+GI+HG V+AGVIGA+KPQYDIWG TVN+ASRMDST
Sbjct: 975 EFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDST 1034
Query: 1125 GVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTYFL 1170
GV +IQV EET L+L+ G+ RG I VKG +G +KTYF+
Sbjct: 1035 GVLDKIQVTEETSLVLQTLGYTCTCRGIINVKG----KGDLKTYFV 1076
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 595 bits (1535), Expect = e-170
Identities = 388/1102 (35%), Positives = 592/1102 (53%), Gaps = 103/1102 (9%)
Query: 136 PSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSEVVMNVLDVLTKLT 195
P+ +FLN G + D + LY++Y L + ++ +L T
Sbjct: 2 PAKGRYFLNEGE--------------EGPDQDALYEKYQLTSQHGPLLLTLLLVAATACV 47
Query: 196 LLVLHLSLASAPMDPLKG-ILLGFFTGIEVVICAL-VVVRKDTTSHTYLQYSGVVTWVAM 253
L++ +A + DP + +LG + V AL V++ + +L+ ++TW +
Sbjct: 48 ALII---IAFSQGDPSRHQAILGMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACL 104
Query: 254 TTQILAAGLGYGLLGDG----------IGYVLFTLFATYSMLPLPLTWAILAG-LGTSLL 302
LGY L+ D + + LF +F Y++LP + A+ G + T+
Sbjct: 105 VA------LGYVLVFDAWTKAACAWEQVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASH 158
Query: 303 QVILQVVIPRLAVISIN---QVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCVEA 359
++L ++ S+ Q++A AV+F+C N G F + A R F T +C++
Sbjct: 159 LLVLGSLMGGFTTPSVRVGLQLLANAVIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQI 218
Query: 360 RLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEH------LQHQFHRIYIHRYENV 413
R +L E ++QE L+LSVLP + + M + EH + FH +Y+ R++NV
Sbjct: 219 RRKLRIEKRQQENLLLSVLPAHISMGMKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNV 278
Query: 414 SILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPE 473
SIL+AD+ GFT L++ S +ELV +LNELF +FD++A + C+RIKILGDCYYCVSGLP
Sbjct: 279 SILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPV 338
Query: 474 PRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWD 533
HA CV+MGL M + I+ VR T D++MR+GIHSG+VLCGV+GLRKWQ+DVWS D
Sbjct: 339 SLPTHARNCVKMGLDMCQAIKQVREATGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHD 398
Query: 534 VDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDS 593
V +AN++E+ G+PGR+HI++ATL L+ Y VE+GHG++R+ +L++ NI TYL+ P
Sbjct: 399 VSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQ 458
Query: 594 LLSLPEDIV---KESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLL 650
P + K + R + T SW PF ++ +++ + T
Sbjct: 459 QPPPPSQHLPRPKGDAALKMRASVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRR 518
Query: 651 PNHLAQALHVQSGPEEINKRIEHTIDLRSGDKL--------------RREHIKPFSLMFK 696
P + Q H ++ ++ + D + L + + F +F
Sbjct: 519 PKSVPQR-HRRTPDRSMSPKGRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFL 577
Query: 697 DSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILI-MLHSAL 755
+ E +Y + + CA ++ + I + LL R + + F ++ +L L
Sbjct: 578 EKGFEREYRLAPIPRARHDFACASLIFVCILLVHVLL-MPRTAALGVSFGLVACVLGLVL 636
Query: 756 VLITTAEDYKCLPLILRKTCCWINETY----LARNVIIFASILINFLGAILNILWCDFD- 810
L + +C P R T C I+E L R + +I AI+N+ F
Sbjct: 637 GLCFATKFSRCCPA--RGTLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQV 694
Query: 811 KSIPLKNLT--FNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAI 868
+P+ N T +S+ +C Y+ + VL + C+VFLR++ K+ +L + +
Sbjct: 695 PELPVGNETGLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVA 754
Query: 869 YALLT--------ETVYAGLFLRYDNLNHSGEDFLGTKEVS---LLLMAMFLLAVFYH-- 915
Y +L + GL NL GT S L M F L +FY
Sbjct: 755 YLVLFNLSPCWQWDCCGQGL----GNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITL 810
Query: 916 ---GQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEE 972
+Q++Y RLD LW+ + K+E E + + N +L N+LP+HVA HF+ D+ NE+
Sbjct: 811 LTLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIG-DKLNED 869
Query: 973 LYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEK 1032
Y QSYD V VMFAS+P F FY++ ++N +G+ECLRLLNEIIADFDELL + +F +EK
Sbjct: 870 WYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEK 929
Query: 1033 IKTIGSTYMAVSGLSP----EKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELR 1088
IKTIGSTYMA +GLS E Q+ E + H+ + +FS+AL + IN+HSFN+F LR
Sbjct: 930 IKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLR 989
Query: 1089 IGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFD 1148
+GI+HG V+AGVIGA+KPQYDIWG TVN+ASRM+STG G+IQV EET IL+ G++ +
Sbjct: 990 VGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCE 1049
Query: 1149 YRGEIYVKGISEQEGKIKTYFL 1170
RG I VKG +G+++TYF+
Sbjct: 1050 CRGLINVKG----KGELRTYFV 1067
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 595 bits (1535), Expect = e-170
Identities = 374/984 (38%), Positives = 552/984 (56%), Gaps = 72/984 (7%)
Query: 245 SGVVTWVAMTTQILAAGLGYGLLG------DGIGYVLFTLFATYSMLPLPLTWAILAGLG 298
SG+V WVA+ LA G + G D + Y LF +F Y+MLPL + A +AGL
Sbjct: 93 SGLV-WVAL----LALGHAFLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLA 147
Query: 299 TSLLQVILQVVI----PRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETR 354
+SL +++ + P + Q+ A AVLF+C N AG++ L +RA R F E
Sbjct: 148 SSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREAL 207
Query: 355 RCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMT------NVEDEHLQHQFHRIYIH 408
+ +R RL+TE + QE L+LS+LP ++ EM ++ + FH +Y+
Sbjct: 208 SSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVK 267
Query: 409 RYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCV 468
R++ VS+L+AD+ GFT L++ S +ELV MLNELF +FD++A EH C+RIKILGDCYYCV
Sbjct: 268 RHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCV 327
Query: 469 SGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFD 528
SGLP DHA CV MGL M + IR +R+ T D++MR+G+HSGSVLCGV+GL+KWQ+D
Sbjct: 328 SGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYD 387
Query: 529 VWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIK 588
VWS DV +AN +E+GG+PGR+HI+ ATL L G Y VE+ + R+ +LR+ TYL+
Sbjct: 388 VWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEHRDPYLRELGEPTYLVI 447
Query: 589 QP---EDSLLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRN 645
P E+ ++ R + T SW PF ++ + ++ T
Sbjct: 448 DPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPL 507
Query: 646 SINLLPNHLAQ-ALHVQSGPEEINKRIE-------HTIDLRSGDKLRREH--IKPFSLMF 695
L + Q +L P ++ ++ I+ + K ++ P +L F
Sbjct: 508 PEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYF 567
Query: 696 KDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSAL 755
++ +E +Y FK C F+V L IQ L+ ++R + I +SI +L +
Sbjct: 568 REKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLV-TNRPPALAITYSITFLLFLLI 626
Query: 756 VLITTAEDYKCLPLILRKTCCWINETYLA-------RNVIIFASILINFLGAILNILW-- 806
+ + +ED L K W+ R + A+IL+ F AI ++ +
Sbjct: 627 LFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFP 686
Query: 807 ----CDFDK---SIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVLKL 859
C F S + NL++ + S P Y + L ++C++FL ++ LKL
Sbjct: 687 TSSDCPFQAPNVSSMISNLSWELPGSLP-LISVP-YSMHCCTLGFLSCSLFLHMSFELKL 744
Query: 860 AVLLIMIAI--------YALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLA 911
+LL+ +A +A L+E + L+L L+ K + + +F
Sbjct: 745 LLLLLWLAASCSLFLHSHAWLSECLIVRLYL--GPLDSRPGVLKEPKLMGAISFFIFFFT 802
Query: 912 VFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNE 971
+ +Q EY RLDFLW+ + ++E E + + +L N+LP+HVA F+ ++R NE
Sbjct: 803 LLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNE 862
Query: 972 ELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIE 1031
+LY QSY+ V V+FAS+P F +FYS++ +N++G+ECLRLLNEIIADFDELL + +F +E
Sbjct: 863 DLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVE 922
Query: 1032 KIKTIGSTYMAVSGLS-----PEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFE 1086
KIKTIGSTYMA +GL+ +Q E HL + +F++AL + INKHSFNNF
Sbjct: 923 KIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFR 982
Query: 1087 LRIGISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFA 1146
LR+G++HG VVAGVIGA+KPQYDIWG TVN+ASRM+STGV G+IQV EET L+ G+
Sbjct: 983 LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYT 1042
Query: 1147 FDYRGEIYVKGISEQEGKIKTYFL 1170
RG I VKG +G++ TYFL
Sbjct: 1043 CYSRGVIKVKG----KGQLCTYFL 1062
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 221 bits (563), Expect = 3e-57
Identities = 118/323 (36%), Positives = 184/323 (56%), Gaps = 27/323 (8%)
Query: 278 LFATYSMLPLPLTWAILAGLGTSLLQVIL------QVVIPRLAVISIN-QVVAQAVLFMC 330
LF Y+++ LPL ++ G+ S+L + P +++ +++++ +L C
Sbjct: 231 LFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGC 290
Query: 331 MNTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDM 390
++ G+ + +S R FL+ + + LE E +ER++ SV+PR + +++
Sbjct: 291 IHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQG 350
Query: 391 TNVEDEHLQHQ--------------------FHRIYIHRYENVSILFADVKGFTNLSTTL 430
+ ++ F + + E VSILFAD+ GFT +S
Sbjct: 351 DEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANK 410
Query: 431 SAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMI 490
SA LV +LN+LF RFDRL E C +I LGDCYYCV+G PEPR DHA+CC+EMGL MI
Sbjct: 411 SAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMI 470
Query: 491 KTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIH 550
K I K V+MR+G+H+G+VLCG+LG+R+++FDVWS DV++AN +E G+ G++H
Sbjct: 471 KAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVH 530
Query: 551 ISKATLDCLNGDYNVEEGHGKER 573
IS+AT L+ Y +E+G ER
Sbjct: 531 ISEATAKYLDDRYEMEDGKVIER 553
Score = 209 bits (532), Expect = 1e-53
Identities = 169/540 (31%), Positives = 268/540 (49%), Gaps = 70/540 (12%)
Query: 673 HTIDLRSGDKLRREH-----IKPFSLMFKDSSLEHKY-SQMRDEVFKSNLVCAFIVLLFI 726
H +D+ D L +++ I FSL F D LE Y + ++EV K++ V F F
Sbjct: 727 HFVDVIKEDSLMKDYFFKPPINQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFS 786
Query: 727 TAIQSLLPSSRVMPMTIQFSILIMLHSALVL---ITTAEDYKCLPLILRKTCCWINETYL 783
+ + L S + +T+ + + +A V A L L + I +
Sbjct: 787 SLLDVFL--STTVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFF 844
Query: 784 ARNVIIFASILINFL---------GAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPE 834
+V+ L+ ++ GAIL S+P + + ++ + +P
Sbjct: 845 LEDVMACTKRLLEWIAGWLPRHCIGAIL--------VSLPALAVYSHVTSEYETNIHFPV 896
Query: 835 YFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIAIYALLTETVYAGLFLRYDNL------- 887
+ ++A+V F +L+S ++ ++ ++ A LL +Y L L
Sbjct: 897 FTGSAALIAVVHYCNFCQLSSWMRSSLATVVGAGPLLL---LYVSLCPDSSVLTSPLDAV 953
Query: 888 -NHSGE----------------DFLGTKEVSLLLMAMFLLAVFYHGQQLEYTARLDFLWR 930
N S E +G + V L+ + LL V++ ++ E + RL +
Sbjct: 954 QNFSSERNPCNSSVPRDLRRPASLIGQEVV--LVFFLLLLLVWFLNREFEVSYRLHYHGD 1011
Query: 931 VQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPG 990
V+A +++ +R+ + +LRNI+P HVA + YS+++D+ GV+FASI
Sbjct: 1012 VEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVS-----QTYSKNHDSGGVIFASIVN 1066
Query: 991 FADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSP-E 1049
F++FY E G EC R+LNE+I DFDELL + + IEKIKTIG+TYMA SGL+ +
Sbjct: 1067 FSEFYE--ENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQ 1124
Query: 1050 KQQCEDKWGHLCALADFSLALTESIQEINKHS-FNNFELRIGISHGSVVAGVIGAKKPQY 1108
Q HL L +F+ + + + N + + NF+LR+G +HG + AGVIG K Y
Sbjct: 1125 AQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLY 1184
Query: 1109 DIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYVKGISEQEGKIKTY 1168
DIWG TVN+ASRMD+TGV RIQV EE+Y +L G+ FDYRG + VKG +G++KTY
Sbjct: 1185 DIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKG----KGQMKTY 1240
Score = 87.8 bits (216), Expect = 6e-17
Identities = 55/203 (27%), Positives = 100/203 (49%), Gaps = 21/203 (10%)
Query: 976 QSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKT 1035
Q + V ++FA I GF ++ N + LLN++ FD L E + EKI T
Sbjct: 388 QQIEEVSILFADIVGF----TKMSANKSAHALVGLLNDLFGRFDRLCEETK---CEKIST 440
Query: 1036 IGSTYMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGS 1095
+G Y V+G E + H + L + ++I++ + +R+G+ G+
Sbjct: 441 LGDCYYCVAGCP------EPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGT 494
Query: 1096 VVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQ-----GFAFDYR 1150
V+ G++G ++ ++D+W VNLA+ M+ GV+G++ + E T L D+ G +
Sbjct: 495 VLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDGKVIERL 554
Query: 1151 GEIYVKGISEQEGKIKTYFLLGR 1173
G+ V ++Q +KTY + G+
Sbjct: 555 GQSVV---ADQLKGLKTYLISGQ 574
Score = 63.5 bits (153), Expect = 1e-09
Identities = 44/186 (23%), Positives = 86/186 (46%), Gaps = 15/186 (8%)
Query: 390 MTNVEDEHLQHQFH--RIYIHRYENVSILFADVKGFTNL--STTLSAQELVRMLNELFAR 445
+ N+ H+ Q + Y +++ ++FA + F+ +E R+LNEL
Sbjct: 1032 LRNIIPYHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGD 1091
Query: 446 FDRLAHE---HHCLRIKILGDCYYCVSGLPEPR-------QDHAHCCVEMGLSMIKTIR- 494
FD L + +IK +G Y SGL + Q+H E M++ +
Sbjct: 1092 FDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDD 1151
Query: 495 YVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKA 554
+ + + +R+G + G + GV+G K +D+W V+IA+++++ G+ RI +S+
Sbjct: 1152 FNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEE 1211
Query: 555 TLDCLN 560
+ L+
Sbjct: 1212 SYRVLS 1217
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 124 bits (311), Expect = 6e-28
Identities = 83/242 (34%), Positives = 135/242 (55%), Gaps = 23/242 (9%)
Query: 934 KEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFAD 993
+E E + E +L ILP VA E+ + E + ++++D+V + F+ I GF
Sbjct: 832 EERTQAYLEEKRKAEALLYQILPHSVA----EQLKRGETVQAEAFDSVTIYFSDIVGFTA 887
Query: 994 FYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQC 1053
+++ ++ + LLN++ FD ++ D F D+ K++TIG YM VSGL +
Sbjct: 888 LSAESTP----MQVVTLLNDLYTCFDAVI--DNF-DVYKVETIGDAYMVVSGLPVRNGRL 940
Query: 1054 EDKWGHLCALADFSLALTESIQE--INKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIW 1111
H C +A +LAL ++++ I LRIGI G V AGV+G K P+Y ++
Sbjct: 941 -----HACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLF 995
Query: 1112 GKTVNLASRMDSTGVSGRIQVPEETYLILKD-QGFAFDYRGEIYVKGISEQEGKIKTYFL 1170
G TVN ASRM+S G + +I + ET +L++ GF + RG++ +KG +GK++TY+L
Sbjct: 996 GDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKG----KGKVRTYWL 1051
Query: 1171 LG 1172
LG
Sbjct: 1052 LG 1053
Score = 102 bits (254), Expect = 2e-21
Identities = 77/260 (29%), Positives = 130/260 (50%), Gaps = 30/260 (11%)
Query: 332 NTAGIFISYLSDRAQRQAFLETRRCVEARLRLETENQRQ-ERLVLSVLPRFVVLEMINDM 390
N++ I + LS Q LE VE R + E +R+ E L+ +LP V ++
Sbjct: 808 NSSNILDNLLSRMEQYANNLE--ELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGE 865
Query: 391 TNVEDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLA 450
T + +++V+I F+D+ GFT LS + ++V +LN+L+ FD +
Sbjct: 866 T-------------VQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVI 912
Query: 451 HEHHCLRIKILGDCYYCVSGLPEPRQDHAHCC--VEMGLSMIKTIR--YVRSRTKHDVDM 506
+++ +GD Y VSGLP R H C M L+++ +R +R R + + +
Sbjct: 913 DNFDVYKVETIGDAYMVVSGLP-VRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRL 971
Query: 507 RIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLN--GDYN 564
RIGIH+G V GV+GL+ ++ ++ V+ A+++ES G +IH+S T L G +
Sbjct: 972 RIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFE 1031
Query: 565 VE-------EGHGKERNEFL 577
+E +G GK R +L
Sbjct: 1032 LELRGDVEMKGKGKVRTYWL 1051
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 118 bits (295), Expect = 4e-26
Identities = 84/251 (33%), Positives = 135/251 (53%), Gaps = 23/251 (9%)
Query: 934 KEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFAD 993
+E E + E +L ILP VA E+ + E + ++++D+V + F+ I GF
Sbjct: 817 EERTQAYLEEKRKAEALLYQILPHSVA----EQLKRGETVQAEAFDSVTIYFSDIVGFTA 872
Query: 994 FYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQC 1053
+++ ++ + LLN++ FD ++ D F D+ K++TIG YM VSGL Q
Sbjct: 873 LSAESTP----MQVVTLLNDLYTCFDAII--DNF-DVYKVETIGDAYMVVSGLPGRNGQ- 924
Query: 1054 EDKWGHLCALADFSLALTESIQE--INKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIW 1111
H +A +LAL +++ I + LRIG+ G V AGV+G K P+Y ++
Sbjct: 925 ----RHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLF 980
Query: 1112 GKTVNLASRMDSTGVSGRIQVPEETYLILKDQG-FAFDYRGEIYVKGISEQEGKIKTYFL 1170
G TVN ASRM+S G + +I V T L + G F + RG++ +KG +GK++TY+L
Sbjct: 981 GDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKG----KGKMRTYWL 1036
Query: 1171 LGRVQPNPFIL 1181
LG + P +L
Sbjct: 1037 LGERKGPPGLL 1047
Score = 101 bits (251), Expect = 5e-21
Identities = 71/236 (30%), Positives = 123/236 (52%), Gaps = 26/236 (11%)
Query: 355 RCVEARLRLETENQRQ-ERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENV 413
+ VE R + E +R+ E L+ +LP V ++ T + +++V
Sbjct: 814 KLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGET-------------VQAEAFDSV 860
Query: 414 SILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLP- 472
+I F+D+ GFT LS + ++V +LN+L+ FD + +++ +GD Y VSGLP
Sbjct: 861 TIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPG 920
Query: 473 EPRQDHAHCCVEMGLSMIKTIRYVRSRTK-HD-VDMRIGIHSGSVLCGVLGLRKWQFDVW 530
Q HA M L+++ + R R + HD + +RIG+H+G V GV+GL+ ++ ++
Sbjct: 921 RNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLF 980
Query: 531 SWDVDIANKLESGGIPGRIHISKATLDCLN--GDYNVE-------EGHGKERNEFL 577
V+ A+++ES G +IH+S T D L+ G + +E +G GK R +L
Sbjct: 981 GDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWL 1036
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 115 bits (288), Expect = 3e-25
Identities = 92/298 (30%), Positives = 151/298 (50%), Gaps = 34/298 (11%)
Query: 920 EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYD 979
+Y++ L+ L R E E++ ++ E +L +LP VA E + + + +D
Sbjct: 830 QYSSNLEDLIR----ERTEELEIEKQKTEKLLTQMLPPSVA----ESLKKGCTVEPEGFD 881
Query: 980 AVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGST 1039
V + F+ I GF + +E +E + LLN++ FD ++G D+ K++TIG
Sbjct: 882 LVTLYFSDIVGFTTISAMSEP----IEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDA 934
Query: 1040 YMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNF--ELRIGISHGSVV 1097
YM SGL P++ H +A+ SL + S+ +RIG+ G VV
Sbjct: 935 YMVASGL-PKRNGSR----HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVV 989
Query: 1098 AGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKD--QGFAFDYRGEIYV 1155
AGV+G P+Y ++G TVN ASRM+STG+ RI V T IL++ +G+ + RG +
Sbjct: 990 AGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTEL 1049
Query: 1156 KGISEQEGKIKTYFLLGR---VQPNPFILPPRRLPGQ--YSLAAVVLGLVQSLNRQRQ 1208
KG +G +T++L+G+ ++P P + PP GQ + L V + Q +RQ
Sbjct: 1050 KG----KGTEETFWLIGKKGFMKPLP-VPPPVDKDGQVGHGLQPVEIAAFQRRKAERQ 1102
Score = 107 bits (268), Expect = 5e-23
Identities = 75/242 (30%), Positives = 125/242 (51%), Gaps = 22/242 (9%)
Query: 363 LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKG 422
LE E Q+ E+L+ +LP V E + VE E ++ V++ F+D+ G
Sbjct: 846 LEIEKQKTEKLLTQMLPPSVA-ESLKKGCTVEPEG------------FDLVTLYFSDIVG 892
Query: 423 FTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPR-QDHAHC 481
FT +S E+V +LN+L+ FD + H +++ +GD Y SGLP+ HA
Sbjct: 893 FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAE 952
Query: 482 CVEMGLSMIKTIRYVRSRTKHDVD--MRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK 539
M L ++ ++ + R +V +RIG+HSG V+ GV+GL ++ ++ V+ A++
Sbjct: 953 IANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASR 1012
Query: 540 LESGGIPGRIHISKATLDCLNGDYNVEEGHGKE---RNEFLRKHNIETYLIKQPEDSLLS 596
+ES G+P RIH+S +T+ L N+ EG+ E R E K ET+ + + +
Sbjct: 1013 MESTGLPYRIHVSLSTVTILQ---NLSEGYEVELRGRTELKGKGTEETFWLIGKKGFMKP 1069
Query: 597 LP 598
LP
Sbjct: 1070 LP 1071
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 110 bits (275), Expect = 8e-24
Identities = 70/229 (30%), Positives = 117/229 (51%), Gaps = 16/229 (6%)
Query: 937 INEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYS 996
+ +++ ++ + +L ++LP VA R + ++ YD V ++F+ I GF F S
Sbjct: 380 LRALEDEKKKTDTLLYSVLPPSVANEL----RHKRPVPAKRYDNVTILFSGIVGFNAFCS 435
Query: 997 QTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDK 1056
+ ++ + LLN++ FD L + + K++T+G YM VSGL + C
Sbjct: 436 KHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLP---EPCIHH 492
Query: 1057 WGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVN 1116
+C LA + + +Q + + ++ IGI G VV GVIG + P+Y ++G TVN
Sbjct: 493 ARSICHLALDMMEIAGQVQVDGE----SVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVN 548
Query: 1117 LASRMDSTGVSGRIQVPEETYLIL-----KDQGFAFDYRGEIYVKGISE 1160
L SR ++TG G+I V E TY L D F ++RG + +KG E
Sbjct: 549 LTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKE 597
Score = 96.7 bits (239), Expect = 1e-19
Identities = 75/251 (29%), Positives = 124/251 (49%), Gaps = 35/251 (13%)
Query: 363 LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKG 422
LE E ++ + L+ SVLP V E L+H+ + RY+NV+ILF+ + G
Sbjct: 383 LEDEKKKTDTLLYSVLPPSVANE------------LRHK-RPVPAKRYDNVTILFSGIVG 429
Query: 423 FTNLSTTLS----AQELVRMLNELFARFDRLAHEHH---CLRIKILGDCYYCVSGLPEPR 475
F + + A ++V +LN+L+ RFD L +++ +GD Y VSGLPEP
Sbjct: 430 FNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPC 489
Query: 476 QDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVD 535
HA + L M++ V+ + V + IGIH+G V+ GV+G R ++ ++ V+
Sbjct: 490 IHHARSICHLALDMMEIAGQVQVDGE-SVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVN 548
Query: 536 IANKLESGGIPGRIHISKATLDCLNGDYNVE-EGHGKERNE-------------FLRKHN 581
+ ++ E+ G G+I++S+ T CL N + + H + R FL + N
Sbjct: 549 LTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKN 608
Query: 582 IETYLIKQPED 592
T KQ +D
Sbjct: 609 TGTEETKQDDD 619
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 110 bits (274), Expect = 1e-23
Identities = 85/274 (31%), Positives = 135/274 (49%), Gaps = 29/274 (10%)
Query: 920 EYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYD 979
+Y++ L+ L R E E++ ++ + +L +LP VA E + + + ++
Sbjct: 826 QYSSNLEDLIR----ERTEELELEKQKTDRLLTQMLPPSVA----EALKTGTPVEPEYFE 877
Query: 980 AVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGST 1039
V + F+ I GF + +E +E + LLN++ FD ++G D+ K++TIG
Sbjct: 878 QVTLYFSDIVGFTTISAMSEP----IEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDA 930
Query: 1040 YMAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNF--ELRIGISHGSVV 1097
YM SGL Q H +A+ SL + ++ +RIG+ G V
Sbjct: 931 YMVASGLPQRNGQ-----RHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCV 985
Query: 1098 AGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILK--DQGFAFDYRGEIYV 1155
AGV+G P+Y ++G TVN ASRM+STG+ RI V T IL+ D G+ + RG +
Sbjct: 986 AGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTEL 1045
Query: 1156 KGISEQEGKIKTYFLLGRVQPN-PFILPPRRLPG 1188
KG +G T++L+GR N P PP PG
Sbjct: 1046 KG----KGAEDTFWLVGRRGFNKPIPKPPDLQPG 1075
Score = 109 bits (273), Expect = 1e-23
Identities = 70/210 (33%), Positives = 113/210 (53%), Gaps = 19/210 (9%)
Query: 363 LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKG 422
LE E Q+ +RL+ +LP V E + T VE E+ +E V++ F+D+ G
Sbjct: 842 LELEKQKTDRLLTQMLPPSVA-EALKTGTPVEPEY------------FEQVTLYFSDIVG 888
Query: 423 FTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPR-QDHAHC 481
FT +S E+V +LN+L+ FD + H +++ +GD Y SGLP+ Q HA
Sbjct: 889 FTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAE 948
Query: 482 CVEMGLSMIKTIRYVRSRTKHDVD--MRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANK 539
M L ++ + R R +V +RIG+HSG + GV+GL ++ ++ V+ A++
Sbjct: 949 IANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASR 1008
Query: 540 LESGGIPGRIHISKAT---LDCLNGDYNVE 566
+ES G+P RIH++ +T L L+ Y VE
Sbjct: 1009 MESTGLPYRIHVNLSTVGILRALDSGYQVE 1038
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 104 bits (259), Expect = 6e-22
Identities = 97/332 (29%), Positives = 144/332 (43%), Gaps = 39/332 (11%)
Query: 921 YTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDA 980
Y+ L+ L +E K R+ + + +LP V + EK ELY +
Sbjct: 771 YSRNLEHL----VEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEE---- 822
Query: 981 VGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTY 1040
V + F+ I GF + +E + +LN+I FD ++ D+ K++TIG Y
Sbjct: 823 VTIYFSDIVGFTTICKYSTP----MEVVDMLNDIYKSFDHIVDH---HDVYKVETIGDAY 875
Query: 1041 MAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFEL--RIGISHGSVVA 1098
M SGL H +A +L + + + RIG+ G A
Sbjct: 876 MVASGLPKRNGN-----RHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAA 930
Query: 1099 GVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILK--DQGFAFDYRGEIYVK 1156
GV+G K P+Y ++G TVN ASRM+STG+ RI V T ILK + F ++ RGE Y+K
Sbjct: 931 GVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLK 990
Query: 1157 GISEQEGKIKTYFLLGRVQPNPFILP-PRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNEN 1215
G G TY+L G ++ F LP P + Q L A ++ + ++RQ
Sbjct: 991 G----RGNETTYWLTG-MKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQ------- 1038
Query: 1216 NNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDK 1247
I+ RR GT Q TDK
Sbjct: 1039 --AAGIRSQKPRRVASYKKGTLEYLQLNTTDK 1068
Score = 99.8 bits (247), Expect = 1e-20
Identities = 71/234 (30%), Positives = 120/234 (51%), Gaps = 27/234 (11%)
Query: 357 VEARLRL-ETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSI 415
VE R +L + E R +RL +LPR VV + + + VE E YE V+I
Sbjct: 779 VEERTQLYKAERDRADRLNFMLLPRLVV-KSLKEKGFVEPE------------LYEEVTI 825
Query: 416 LFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPR 475
F+D+ GFT + + E+V MLN+++ FD + H +++ +GD Y SGLP+
Sbjct: 826 YFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRN 885
Query: 476 QD-HAHCCVEMGLSMIKTIR--YVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSW 532
+ HA +M L ++ + + + +RIG+HSG GV+G++ ++ ++
Sbjct: 886 GNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGD 945
Query: 533 DVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYL 586
V+ A+++ES G+P RIH+S +T+ L + +FL + ETYL
Sbjct: 946 TVNTASRMESTGLPLRIHVSGSTIAILK----------RTECQFLYEVRGETYL 989
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 103 bits (257), Expect = 1e-21
Identities = 61/197 (30%), Positives = 103/197 (52%), Gaps = 13/197 (6%)
Query: 363 LETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILFADVKG 422
LE E ++ L+ S+ P V ++ Q ++ ++++V++LF+D+ G
Sbjct: 483 LEEEKKKTVDLLYSIFPGDVAQQL-------------WQGQQVQARKFDDVTMLFSDIVG 529
Query: 423 FTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCC 482
FT + + +++ MLNEL+ RFD +++ +GD Y +GL HA
Sbjct: 530 FTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPI 589
Query: 483 VEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLES 542
M L M++ V + + MRIGIHSGSVL GV+G+R ++ ++ +V +A+K ES
Sbjct: 590 ALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFES 649
Query: 543 GGIPGRIHISKATLDCL 559
G P RI++S T L
Sbjct: 650 GSHPRRINVSPTTYQLL 666
Score = 98.2 bits (243), Expect = 4e-20
Identities = 72/240 (30%), Positives = 119/240 (49%), Gaps = 18/240 (7%)
Query: 940 MKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999
++E ++ ++L +I P VA+ + +++ ++ +D V ++F+ I GF +Q
Sbjct: 483 LEEEKKKTVDLLYSIFPGDVAQQLWQ----GQQVQARKFDDVTMLFSDIVGFTAICAQCT 538
Query: 1000 MNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGH 1059
++ + +LNE+ FD G F DI K++TIG Y +GL K C H
Sbjct: 539 P----MQVISMLNELYTRFDHQCG---FLDIYKVETIGDAYCVAAGLH-RKSLC-----H 585
Query: 1060 LCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLAS 1119
+A +L + E +E+ ++RIGI GSV+AGV+G + P+Y ++G V LAS
Sbjct: 586 AKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLAS 645
Query: 1120 RMDSTGVSGRIQVPEETYLILK-DQGFAFDYRGEIYVKGISEQEGKIKTYFLLGRVQPNP 1178
+ +S RI V TY +LK ++ F F R + +E YFL R P P
Sbjct: 646 KFESGSHPRRINVSPTTYQLLKREESFTFIPRSREELPDNFPKEIPGICYFLEVRTGPKP 705
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 101 bits (252), Expect = 4e-21
Identities = 60/198 (30%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 358 EARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILF 417
+A LE E ++ L+ S+ P V ++ Q + ++ NV++LF
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL-------------WQGQVVQAKKFSNVTMLF 484
Query: 418 ADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQD 477
+D+ GFT + + S +++ MLN L+ RFD+ E +++ +GD Y GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDT 544
Query: 478 HAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIA 537
HA M L M++ V S + MRIG+HSGSV GV+G++ ++ ++ +V +A
Sbjct: 545 HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 604
Query: 538 NKLESGGIPGRIHISKAT 555
NK ES +P +I++S T
Sbjct: 605 NKFESCSVPRKINVSPTT 622
Score = 85.9 bits (211), Expect = 2e-16
Identities = 56/198 (28%), Positives = 97/198 (48%), Gaps = 17/198 (8%)
Query: 940 MKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999
++E ++ ++L +I P VA+ + + + ++ + V ++F+ I GF SQ
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQ----GQVVQAKKFSNVTMLFSDIVGFTAICSQCS 498
Query: 1000 MNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGH 1059
++ + +LN + FD+ GE D+ K++TIG Y GL E H
Sbjct: 499 P----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKESDT------H 545
Query: 1060 LCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLAS 1119
+A +L + E E+ ++RIG+ GSV AGV+G K P+Y ++G V LA+
Sbjct: 546 AVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLAN 605
Query: 1120 RMDSTGVSGRIQVPEETY 1137
+ +S V +I V TY
Sbjct: 606 KFESCSVPRKINVSPTTY 623
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 101 bits (252), Expect = 4e-21
Identities = 60/198 (30%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 358 EARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILF 417
+A LE E ++ L+ S+ P V ++ Q + ++ NV++LF
Sbjct: 203 QAHQALEEEKKKTVDLLCSIFPCEVAQQL-------------WQGQVVQAKKFSNVTMLF 249
Query: 418 ADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQD 477
+D+ GFT + + S +++ MLN L+ RFD+ E +++ +GD Y GL +
Sbjct: 250 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDT 309
Query: 478 HAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIA 537
HA M L M++ V S + MRIG+HSGSV GV+G++ ++ ++ +V +A
Sbjct: 310 HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 369
Query: 538 NKLESGGIPGRIHISKAT 555
NK ES +P +I++S T
Sbjct: 370 NKFESCSVPRKINVSPTT 387
Score = 94.0 bits (232), Expect = 8e-19
Identities = 63/212 (29%), Positives = 105/212 (49%), Gaps = 18/212 (8%)
Query: 940 MKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999
++E ++ ++L +I P VA+ + + + ++ + V ++F+ I GF SQ
Sbjct: 208 LEEEKKKTVDLLCSIFPCEVAQQLWQ----GQVVQAKKFSNVTMLFSDIVGFTAICSQCS 263
Query: 1000 MNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGH 1059
++ + +LN + FD+ GE D+ K++TIG Y GL E H
Sbjct: 264 P----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKESDT------H 310
Query: 1060 LCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLAS 1119
+A +L + E E+ ++RIG+ GSV AGV+G K P+Y ++G V LA+
Sbjct: 311 AVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLAN 370
Query: 1120 RMDSTGVSGRIQVPEETYLILKD-QGFAFDYR 1150
+ +S V +I V TY +LKD GF F R
Sbjct: 371 KFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 402
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 101 bits (252), Expect = 4e-21
Identities = 60/198 (30%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 358 EARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILF 417
+A LE E ++ L+ S+ P V ++ Q + ++ NV++LF
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL-------------WQGQVVQAKKFSNVTMLF 484
Query: 418 ADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQD 477
+D+ GFT + + S +++ MLN L+ RFD+ E +++ +GD Y GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDT 544
Query: 478 HAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIA 537
HA M L M++ V S + MRIG+HSGSV GV+G++ ++ ++ +V +A
Sbjct: 545 HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 604
Query: 538 NKLESGGIPGRIHISKAT 555
NK ES +P +I++S T
Sbjct: 605 NKFESCSVPRKINVSPTT 622
Score = 94.0 bits (232), Expect = 8e-19
Identities = 63/212 (29%), Positives = 105/212 (49%), Gaps = 18/212 (8%)
Query: 940 MKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999
++E ++ ++L +I P VA+ + + + ++ + V ++F+ I GF SQ
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQ----GQVVQAKKFSNVTMLFSDIVGFTAICSQCS 498
Query: 1000 MNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGH 1059
++ + +LN + FD+ GE D+ K++TIG Y GL E H
Sbjct: 499 P----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKESDT------H 545
Query: 1060 LCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLAS 1119
+A +L + E E+ ++RIG+ GSV AGV+G K P+Y ++G V LA+
Sbjct: 546 AVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLAN 605
Query: 1120 RMDSTGVSGRIQVPEETYLILKD-QGFAFDYR 1150
+ +S V +I V TY +LKD GF F R
Sbjct: 606 KFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 637
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 101 bits (252), Expect = 4e-21
Identities = 60/198 (30%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 358 EARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILF 417
+A LE E ++ L+ S+ P V ++ Q + ++ NV++LF
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL-------------WQGQVVQAKKFSNVTMLF 484
Query: 418 ADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQD 477
+D+ GFT + + S +++ MLN L+ RFD+ E +++ +GD Y GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDT 544
Query: 478 HAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIA 537
HA M L M++ V S + MRIG+HSGSV GV+G++ ++ ++ +V +A
Sbjct: 545 HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 604
Query: 538 NKLESGGIPGRIHISKAT 555
NK ES +P +I++S T
Sbjct: 605 NKFESCSVPRKINVSPTT 622
Score = 94.0 bits (232), Expect = 8e-19
Identities = 63/212 (29%), Positives = 105/212 (49%), Gaps = 18/212 (8%)
Query: 940 MKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999
++E ++ ++L +I P VA+ + + + ++ + V ++F+ I GF SQ
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQ----GQVVQAKKFSNVTMLFSDIVGFTAICSQCS 498
Query: 1000 MNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGH 1059
++ + +LN + FD+ GE D+ K++TIG Y GL E H
Sbjct: 499 P----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKESDT------H 545
Query: 1060 LCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLAS 1119
+A +L + E E+ ++RIG+ GSV AGV+G K P+Y ++G V LA+
Sbjct: 546 AVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLAN 605
Query: 1120 RMDSTGVSGRIQVPEETYLILKD-QGFAFDYR 1150
+ +S V +I V TY +LKD GF F R
Sbjct: 606 KFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 637
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 101 bits (252), Expect = 4e-21
Identities = 60/198 (30%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 358 EARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILF 417
+A LE E ++ L+ S+ P V ++ Q + ++ NV++LF
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL-------------WQGQVVQAKKFSNVTMLF 484
Query: 418 ADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQD 477
+D+ GFT + + S +++ MLN L+ RFD+ E +++ +GD Y GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDT 544
Query: 478 HAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIA 537
HA M L M++ V S + MRIG+HSGSV GV+G++ ++ ++ +V +A
Sbjct: 545 HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 604
Query: 538 NKLESGGIPGRIHISKAT 555
NK ES +P +I++S T
Sbjct: 605 NKFESCSVPRKINVSPTT 622
Score = 94.0 bits (232), Expect = 8e-19
Identities = 63/212 (29%), Positives = 105/212 (49%), Gaps = 18/212 (8%)
Query: 940 MKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999
++E ++ ++L +I P VA+ + + + ++ + V ++F+ I GF SQ
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQ----GQVVQAKKFSNVTMLFSDIVGFTAICSQCS 498
Query: 1000 MNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGH 1059
++ + +LN + FD+ GE D+ K++TIG Y GL E H
Sbjct: 499 P----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKESDT------H 545
Query: 1060 LCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLAS 1119
+A +L + E E+ ++RIG+ GSV AGV+G K P+Y ++G V LA+
Sbjct: 546 AVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLAN 605
Query: 1120 RMDSTGVSGRIQVPEETYLILKD-QGFAFDYR 1150
+ +S V +I V TY +LKD GF F R
Sbjct: 606 KFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 637
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 101 bits (252), Expect = 4e-21
Identities = 60/198 (30%), Positives = 103/198 (52%), Gaps = 13/198 (6%)
Query: 358 EARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSILF 417
+A LE E ++ L+ S+ P V ++ Q + ++ NV++LF
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL-------------WQGQVVQAKKFSNVTMLF 484
Query: 418 ADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQD 477
+D+ GFT + + S +++ MLN L+ RFD+ E +++ +GD Y GL +
Sbjct: 485 SDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDT 544
Query: 478 HAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIA 537
HA M L M++ V S + MRIG+HSGSV GV+G++ ++ ++ +V +A
Sbjct: 545 HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLA 604
Query: 538 NKLESGGIPGRIHISKAT 555
NK ES +P +I++S T
Sbjct: 605 NKFESCSVPRKINVSPTT 622
Score = 94.0 bits (232), Expect = 8e-19
Identities = 63/212 (29%), Positives = 105/212 (49%), Gaps = 18/212 (8%)
Query: 940 MKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTE 999
++E ++ ++L +I P VA+ + + + ++ + V ++F+ I GF SQ
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQ----GQVVQAKKFSNVTMLFSDIVGFTAICSQCS 498
Query: 1000 MNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGH 1059
++ + +LN + FD+ GE D+ K++TIG Y GL E H
Sbjct: 499 P----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKESDT------H 545
Query: 1060 LCALADFSLALTESIQEINKHSFNNFELRIGISHGSVVAGVIGAKKPQYDIWGKTVNLAS 1119
+A +L + E E+ ++RIG+ GSV AGV+G K P+Y ++G V LA+
Sbjct: 546 AVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLAN 605
Query: 1120 RMDSTGVSGRIQVPEETYLILKD-QGFAFDYR 1150
+ +S V +I V TY +LKD GF F R
Sbjct: 606 KFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 637
>gi|25777671 protein phosphatase 1, regulatory subunit 10 [Homo
sapiens]
Length = 940
Score = 40.0 bits (92), Expect = 0.014
Identities = 34/107 (31%), Positives = 37/107 (34%), Gaps = 21/107 (19%)
Query: 53 GHR-----GGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTK 107
GHR GGS GSGG P GGP+ H P PG R H G
Sbjct: 828 GHRPHEGPGGSMGGSGGHRPHEGPGHGGPHGHRPHDV-----------PGHRGHDHRGPP 876
Query: 108 VFPERSGSGSASGSGG--GGDLGFLH---LDCAPSNSDFFLNGGYSY 149
R G G GG G D G H + P F + G Y
Sbjct: 877 PHEHRGHDGPGHGGGGHRGHDGGHSHGGDMSNRPVCRHFMMKGNCRY 923
>gi|55956910 meningioma 1 [Homo sapiens]
Length = 1320
Score = 38.9 bits (89), Expect = 0.031
Identities = 23/73 (31%), Positives = 28/73 (38%)
Query: 53 GHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPER 112
G G+G G AS+ P+ L G P + G HS G P
Sbjct: 710 GQLQSPGAGVGLPSAASERRPPPPDFATSALGGQPGFPFGAAGRQSTPHSGPGVNSPPSA 769
Query: 113 SGSGSASGSGGGG 125
G G +SG GGGG
Sbjct: 770 GGGGGSSGGGGGG 782
>gi|4504733 insulin receptor substrate 4 [Homo sapiens]
Length = 1257
Score = 38.5 bits (88), Expect = 0.041
Identities = 35/114 (30%), Positives = 48/114 (42%), Gaps = 10/114 (8%)
Query: 24 AGDGRSASRPQRLLWQTAVRHIT-------EQRFIHGHRGGSGSGSGGSGKASDPAG--G 74
+G+GR + Q Q + H + E + G +G +G GSGG+ + D G G
Sbjct: 495 SGNGRGSGGGQGSNGQGSSSHSSGGNQCSGEGQGSRGGQGSNGQGSGGNQCSRDGQGTAG 554
Query: 75 GPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSASGSGGGGDLG 128
G Q G GPG+ H + G K GSGS GS G G+ G
Sbjct: 555 GHGSGGGQRPGGGHGSGGGQGPGD-GHGSGGGKNSGGGKGSGSGKGSDGDGERG 607
Score = 32.7 bits (73), Expect = 2.2
Identities = 26/86 (30%), Positives = 34/86 (39%), Gaps = 19/86 (22%)
Query: 58 SGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLY---------------SLGPGERAHS 102
SGSGSG G+ +P G + SG +P+ S G G +HS
Sbjct: 461 SGSGSGNFGEEGNPQG----KEDQEGSGGDYMPMNNWGSGNGRGSGGGQGSNGQGSSSHS 516
Query: 103 TCGTKVFPERSGSGSASGSGGGGDLG 128
+ G + E GS GS G G G
Sbjct: 517 SGGNQCSGEGQGSRGGQGSNGQGSGG 542
>gi|55741655 anoctamin 8 [Homo sapiens]
Length = 1232
Score = 37.4 bits (85), Expect = 0.090
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 15/100 (15%)
Query: 716 LVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILRKTC 775
LVC F+++L +Q L+ S + +P +F +ML AL++ +AE YK K
Sbjct: 368 LVCVFLLMLGCFQLQELVLSVKGLPRLARFLPKVML--ALLVSVSAEGYK-------KLA 418
Query: 776 CWIN--ETYLARNV----IIFASILINFLGAILNILWCDF 809
W+N E Y + +I +L F+ + L++ + F
Sbjct: 419 IWLNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGF 458
>gi|40068464 AT rich interactive domain 1B (SWI1-like) isoform 2
[Homo sapiens]
Length = 2191
Score = 37.4 bits (85), Expect = 0.090
Identities = 26/75 (34%), Positives = 31/75 (41%), Gaps = 5/75 (6%)
Query: 53 GHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVF--P 110
G GGSG G GG G + AG G + +A G G S+ G V P
Sbjct: 257 GGGGGSGGGGGGGGAGAGGAGAGA---VAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSP 313
Query: 111 ERSGSGSASGSGGGG 125
+ G G G GGGG
Sbjct: 314 RQQGGGMMMGPGGGG 328
Score = 30.8 bits (68), Expect = 8.5
Identities = 22/75 (29%), Positives = 25/75 (33%), Gaps = 10/75 (13%)
Query: 54 HRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERS 113
H G G G AS A G P P + P +S C R
Sbjct: 197 HGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYP----------NSQCNHYPGYSRP 246
Query: 114 GSGSASGSGGGGDLG 128
G+G G GGGG G
Sbjct: 247 GAGGGGGGGGGGGGG 261
>gi|40068466 AT rich interactive domain 1B (SWI1-like) isoform 1
[Homo sapiens]
Length = 2231
Score = 37.4 bits (85), Expect = 0.090
Identities = 26/75 (34%), Positives = 31/75 (41%), Gaps = 5/75 (6%)
Query: 53 GHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVF--P 110
G GGSG G GG G + AG G + +A G G S+ G V P
Sbjct: 257 GGGGGSGGGGGGGGAGAGGAGAGA---VAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSP 313
Query: 111 ERSGSGSASGSGGGG 125
+ G G G GGGG
Sbjct: 314 RQQGGGMMMGPGGGG 328
Score = 30.8 bits (68), Expect = 8.5
Identities = 22/75 (29%), Positives = 25/75 (33%), Gaps = 10/75 (13%)
Query: 54 HRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERS 113
H G G G AS A G P P + P +S C R
Sbjct: 197 HGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYP----------NSQCNHYPGYSRP 246
Query: 114 GSGSASGSGGGGDLG 128
G+G G GGGG G
Sbjct: 247 GAGGGGGGGGGGGGG 261
>gi|40068462 AT rich interactive domain 1B (SWI1-like) isoform 3
[Homo sapiens]
Length = 2178
Score = 37.4 bits (85), Expect = 0.090
Identities = 26/75 (34%), Positives = 31/75 (41%), Gaps = 5/75 (6%)
Query: 53 GHRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVF--P 110
G GGSG G GG G + AG G + +A G G S+ G V P
Sbjct: 257 GGGGGSGGGGGGGGAGAGGAGAGA---VAAAAAAAAAAAGGGGGGGYGGSSAGYGVLSSP 313
Query: 111 ERSGSGSASGSGGGG 125
+ G G G GGGG
Sbjct: 314 RQQGGGMMMGPGGGG 328
Score = 30.8 bits (68), Expect = 8.5
Identities = 22/75 (29%), Positives = 25/75 (33%), Gaps = 10/75 (13%)
Query: 54 HRGGSGSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERS 113
H G G G AS A G P P + P +S C R
Sbjct: 197 HGGQQSPGMGMMHSASAAAAGAPGSMDPLQNSHEGYP----------NSQCNHYPGYSRP 246
Query: 114 GSGSASGSGGGGDLG 128
G+G G GGGG G
Sbjct: 247 GAGGGGGGGGGGGGG 261
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 46,282,936
Number of Sequences: 37866
Number of extensions: 2161161
Number of successful extensions: 11027
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 9451
Number of HSP's gapped (non-prelim): 1009
length of query: 1251
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1137
effective length of database: 13,930,794
effective search space: 15839312778
effective search space used: 15839312778
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.