Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 45333883
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45333883 kelch repeat and BTB (POZ) domain-containing 6
[Homo sapiens]
(674 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45333883 kelch repeat and BTB (POZ) domain-containing 6 [Homo... 1379 0.0
gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo... 1248 0.0
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 243 4e-64
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 218 1e-56
gi|55925608 kelch-like 21 [Homo sapiens] 179 7e-45
gi|148664248 kelch domain containing 6 [Homo sapiens] 169 1e-41
gi|40807500 kelch-like 20 [Homo sapiens] 167 2e-41
gi|109150407 kelch-like 6 [Homo sapiens] 159 6e-39
gi|40018614 DRE1 protein [Homo sapiens] 155 1e-37
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 146 5e-35
gi|166235129 kelch-like 3 [Homo sapiens] 145 9e-35
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 144 2e-34
gi|223890235 intracisternal A particle-promoted polypeptide isof... 144 2e-34
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 141 2e-33
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 141 2e-33
gi|128485503 kelch-like 30 [Homo sapiens] 139 9e-33
gi|40255071 kelch-like 23 [Homo sapiens] 139 1e-32
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 138 1e-32
gi|34101268 kelch-like 8 [Homo sapiens] 135 1e-31
gi|11056006 kelch-like 12 [Homo sapiens] 135 1e-31
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 132 8e-31
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 132 1e-30
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 132 1e-30
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 131 2e-30
gi|24308181 kelch-like 9 [Homo sapiens] 129 9e-30
gi|45643138 kelch-like 13 [Homo sapiens] 128 2e-29
gi|38194229 kelch-like 17 [Homo sapiens] 128 2e-29
gi|55925604 kelch-like 18 [Homo sapiens] 124 2e-28
gi|38327518 BTB and kelch domain containing 3 [Homo sapiens] 124 3e-28
gi|38327516 BTB and kelch domain containing 3 [Homo sapiens] 124 3e-28
>gi|45333883 kelch repeat and BTB (POZ) domain-containing 6 [Homo
sapiens]
Length = 674
Score = 1379 bits (3569), Expect = 0.0
Identities = 674/674 (100%), Positives = 674/674 (100%)
Query: 1 MQSREDAPRSRRLASPRGGKRPKKIHKPTVSAFFTGPEELKDTAHSAALLAQLKSFYDAR 60
MQSREDAPRSRRLASPRGGKRPKKIHKPTVSAFFTGPEELKDTAHSAALLAQLKSFYDAR
Sbjct: 1 MQSREDAPRSRRLASPRGGKRPKKIHKPTVSAFFTGPEELKDTAHSAALLAQLKSFYDAR 60
Query: 61 LLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
LLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE
Sbjct: 61 LLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
Query: 121 SFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
SFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA
Sbjct: 121 SFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
Query: 181 DAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVC 240
DAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVC
Sbjct: 181 DAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVC 240
Query: 241 HVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ 300
HVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ
Sbjct: 241 HVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ 300
Query: 301 MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCD 360
MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCD
Sbjct: 301 MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCD 360
Query: 361 PYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQQLAD 420
PYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQQLAD
Sbjct: 361 PYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQQLAD 420
Query: 421 RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLM 480
RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLM
Sbjct: 421 RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLM 480
Query: 481 VIRDYLYALNSKRMFCYDPSHNMWLKCVSLKRNDFQEACVFNEEIYCICDIPVMKVYNPV 540
VIRDYLYALNSKRMFCYDPSHNMWLKCVSLKRNDFQEACVFNEEIYCICDIPVMKVYNPV
Sbjct: 481 VIRDYLYALNSKRMFCYDPSHNMWLKCVSLKRNDFQEACVFNEEIYCICDIPVMKVYNPV 540
Query: 541 RAEWRQMNNIPLVSETNNYRIIKHGQKLLLITSRTPQWKKNRVTVYEYDIRGDQWINIGT 600
RAEWRQMNNIPLVSETNNYRIIKHGQKLLLITSRTPQWKKNRVTVYEYDIRGDQWINIGT
Sbjct: 541 RAEWRQMNNIPLVSETNNYRIIKHGQKLLLITSRTPQWKKNRVTVYEYDIRGDQWINIGT 600
Query: 601 TLGLLQFDSNFFCLSARVYPSCLEPGQSFLTEEEEIPSESSTEWDLGGFSEPDSESGSSS 660
TLGLLQFDSNFFCLSARVYPSCLEPGQSFLTEEEEIPSESSTEWDLGGFSEPDSESGSSS
Sbjct: 601 TLGLLQFDSNFFCLSARVYPSCLEPGQSFLTEEEEIPSESSTEWDLGGFSEPDSESGSSS 660
Query: 661 SLSDDDFWVRVAPQ 674
SLSDDDFWVRVAPQ
Sbjct: 661 SLSDDDFWVRVAPQ 674
>gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo
sapiens]
Length = 684
Score = 1248 bits (3230), Expect = 0.0
Identities = 605/674 (89%), Positives = 638/674 (94%)
Query: 1 MQSREDAPRSRRLASPRGGKRPKKIHKPTVSAFFTGPEELKDTAHSAALLAQLKSFYDAR 60
MQSRED PRSRRLASPRGG+RPK+I KP+VSAFFTGPEELKDTAHSAALLAQLKSFYDAR
Sbjct: 1 MQSREDVPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTAHSAALLAQLKSFYDAR 60
Query: 61 LLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
LLCDVTIEVVTPGSGPGTGRLF CNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE
Sbjct: 61 LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
Query: 121 SFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
SFEVLVDYCYTGRVSLSEANV+RLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA
Sbjct: 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
Query: 181 DAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVC 240
DAF H KLRSQAQSYIA NFKQLS MGSIREETLADLTLAQLLAVLRLDSLD+ESE+TVC
Sbjct: 181 DAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVC 240
Query: 241 HVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ 300
HVAVQWLEAA KERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ
Sbjct: 241 HVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ 300
Query: 301 MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCD 360
MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLC D
Sbjct: 301 MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCYD 360
Query: 361 PYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQQLAD 420
PYSGD+Y +PSPLT AHT+TVT+ AVC+SPDHDIYLAAQPR DLWVYKPAQNSWQQLAD
Sbjct: 361 PYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLAD 420
Query: 421 RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLM 480
RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECY+V+RNQWALVAP+PHSF SF+L+
Sbjct: 421 RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELI 480
Query: 481 VIRDYLYALNSKRMFCYDPSHNMWLKCVSLKRNDFQEACVFNEEIYCICDIPVMKVYNPV 540
V+++YLYA+NSKRM CYDPSHNMWL C SLKR+DFQEACVFN+EIYCICDIPVMKVYNP
Sbjct: 481 VVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPA 540
Query: 541 RAEWRQMNNIPLVSETNNYRIIKHGQKLLLITSRTPQWKKNRVTVYEYDIRGDQWINIGT 600
R EWR+++NIPL SET+NY+I+ H QKLLLITS TPQWKKNRVTVYEYD R DQWINIGT
Sbjct: 541 RGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGT 600
Query: 601 TLGLLQFDSNFFCLSARVYPSCLEPGQSFLTEEEEIPSESSTEWDLGGFSEPDSESGSSS 660
LGLLQFDS F CL ARVYPSCLEPGQSF+TEE++ SESSTEWDL GFSE DSESGSSS
Sbjct: 601 MLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARSESSTEWDLDGFSELDSESGSSS 660
Query: 661 SLSDDDFWVRVAPQ 674
S SDD+ WV+VAPQ
Sbjct: 661 SFSDDEVWVQVAPQ 674
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 243 bits (620), Expect = 4e-64
Identities = 174/622 (27%), Positives = 288/622 (46%), Gaps = 90/622 (14%)
Query: 42 DTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFT 101
D H+ ++L QLK+ YD L D+ +EV G+ F C+RNVLAA PYF+SMFT
Sbjct: 28 DPFHACSILKQLKTMYDEGQLTDIVVEV-------DHGKTFSCHRNVLAAISPYFRSMFT 80
Query: 102 GGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACA 161
G+ ES Q V + V+AES +++++Y YT RV L+EANV+ L+ A+ + Q+ +++ CA
Sbjct: 81 SGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCA 140
Query: 162 SFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQ 221
++ LD N + FAD +GH++L +++ YI + F ++ +E+ LT Q
Sbjct: 141 KYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVT-----KEQEFLQLTKDQ 195
Query: 222 LLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVF-KCVRWMHFTEEDQDYLEG 280
L+++L D L+V+ E+ V ++W E ER E+F KC+R+
Sbjct: 196 LISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRF------------- 242
Query: 281 LLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGM 340
P+++ D + ++ + KS V S+++ + QRLGM
Sbjct: 243 ----PLME----DTFIEKIPPQFAQAIAKSCVEKGPSNTNGCT------------QRLGM 282
Query: 341 CAKEMVIFF------GHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHD 394
A EM+I F + C D +G ++K+ P L + + +SPD+D
Sbjct: 283 TASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLRE------VGILVSPDND 336
Query: 395 IYLAAQPR-------------TDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILG 441
IY+A R D W+Y + N W L R G + Y G +Y +G
Sbjct: 337 IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIG 396
Query: 442 GR--DPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSKRMFCYDP 499
GR + LK VECY+ + N W V +P + + + ++ +Y L + Y+P
Sbjct: 397 GRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEP 456
Query: 500 SHNMWLKCVSLKRNDFQE-ACVFNEEIYCICD-------IPVMKVYNPVRAEWRQMNNIP 551
+ W + Q A V+ + IY I + ++ Y+ +W + + P
Sbjct: 457 QKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFP 516
Query: 552 LVSETNNY-RIIKHGQKLLLITSRTPQWKKNRV-------TVYEYDIRGDQWINIGTTLG 603
N Y +++ KL L T + V ++Y+YD DQW+ + T
Sbjct: 517 CDQSINPYLKLVLFQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPD 576
Query: 604 -LLQFDSNFFCLSARVYPSCLE 624
L +F C A++YP CL+
Sbjct: 577 RLWDLGRHFECAVAKLYPQCLQ 598
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 218 bits (556), Expect = 1e-56
Identities = 167/643 (25%), Positives = 291/643 (45%), Gaps = 106/643 (16%)
Query: 35 TGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACP 94
T E +T ++ +LL QLK FY+ +L D+ + V G FPC++ VLA
Sbjct: 3 TQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIV--------EGTEFPCHKMVLATCSS 54
Query: 95 YFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLE 154
YF++MF G+ ES+Q V + +VDA + ++++ Y YTG ++++++ VE+LY + LQ+E
Sbjct: 55 YFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVE 114
Query: 155 YVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETL 214
V + C +L ++++ NC +L FAD F +L+ A+ + F + H ++
Sbjct: 115 DVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYH-----QDAF 169
Query: 215 ADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEED 274
L+ L+ +L D+L+VE E+TV A+ WLE + R + V +R +E
Sbjct: 170 MQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVT 229
Query: 275 Q-DYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAEN 333
Q + +GL P K V++G LYKS+ +
Sbjct: 230 QRAWFQGL--PPNDKSV---VVQG---------LYKSM-------------------PKF 256
Query: 334 PPQRLGMCAKEMVIFFGHPRD------PFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAV 387
RLGM +EM+IF + +C P + +YK+ SP L TV T
Sbjct: 257 FKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVT--- 313
Query: 388 CISPDHDIYLAA------QPRTD----------------LWVYKPAQNSWQQLADRLLCR 425
PD+DIY+A +T+ + + QN+W L R
Sbjct: 314 ---PDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVR 370
Query: 426 EGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDY 485
+ GYIY +GG + + VE Y+ ++++W +V+PLP ++ +V+ D
Sbjct: 371 IKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDC 430
Query: 486 LYALNSKRMFCYDPSHNMWLKCVSLKRN-DFQEACVFNEEIYCICDIPV----------- 533
+Y + M+CY P + W++ + + F A F ++I+ I + +
Sbjct: 431 IYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSG 490
Query: 534 --------MKVYNPVRAEWRQMNNIPLVSETNN-YRIIKHGQKLLLITSRTPQWKKNRVT 584
+++Y+ + EW+ NIP ++ R + L + T ++ +
Sbjct: 491 TVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYV 550
Query: 585 VYEYDIRGDQWI---NIGTTLGLLQFDSNFFCLSARVYPSCLE 624
Y+YD+ D+W +I + L +F C ++YPSCLE
Sbjct: 551 TYQYDLELDRWSLRQHISERV-LWDLGRDFRCTVGKLYPSCLE 592
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 179 bits (454), Expect = 7e-45
Identities = 154/538 (28%), Positives = 239/538 (44%), Gaps = 71/538 (13%)
Query: 42 DTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFT 101
D AH+ +LL L R DVT+E GR FP +R VLAAA PYF++MF
Sbjct: 14 DPAHALSLLRGLSQLRAERKFLDVTLEAAG-------GRDFPAHRAVLAAASPYFRAMFA 66
Query: 102 GGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACA 161
G + ES+ V +H V + ++L+D+ YTGRV++S N E L A+D+LQ V+EAC
Sbjct: 67 GQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACG 126
Query: 162 SFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQ 221
+FL ++LDL NC + FA+AF L S AQ +I L H+G + E L L LA+
Sbjct: 127 AFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFI------LRHVGELGAEQLERLPLAR 180
Query: 222 LLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGL 281
LL LR D L V E+ +A++W+ A P R ++ + VR + F L +
Sbjct: 181 LLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVR-LPFVRRFY-LLAHV 238
Query: 282 LTKPIVKKY--CLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLG 339
+P+V + CL ++ A + P P S+
Sbjct: 239 EAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTG--------------- 283
Query: 340 MCAKEMVIFFGHPRD-----PFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHD 394
A+ +V+ G +D C +P +G + L ++ L +D
Sbjct: 284 -LAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALG------ND 336
Query: 395 IYL-----AAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGV 449
IY+ ++ +W Y + N W ++A L RE + L+G +Y+ V
Sbjct: 337 IYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYV---------V 387
Query: 450 KLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSKR------MFCYDPSHNM 503
E Y+ + W + P+ + + R LYA+ S M CYDP ++
Sbjct: 388 AADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDL 447
Query: 504 W--LKCVSLKRNDF-QEACVFNEEIYCICDIPV-MKVYNPVRAEWRQMNNIPLVSETN 557
W + C L F + N +Y + D + VYNP R EW + IP +++ +
Sbjct: 448 WSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEW---DKIPSMNQVH 502
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/93 (25%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 395 IYLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEV 454
+Y ++ VY P +N W ++ G +A L G +Y+ GG D T V
Sbjct: 472 MYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDN-TFELSDVV 530
Query: 455 ECYNVKRNQWALVAPLPH-SFLSFDLMVIRDYL 486
E Y+ + W++V LP +F + + R ++
Sbjct: 531 EAYDPETRAWSVVGRLPEPTFWHGSVSIFRQFM 563
>gi|148664248 kelch domain containing 6 [Homo sapiens]
Length = 623
Score = 169 bits (427), Expect = 1e-41
Identities = 162/651 (24%), Positives = 275/651 (42%), Gaps = 106/651 (16%)
Query: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGM 104
HS LL ++++ + + DV + G FPC+R VLAA PYFK+MFT G+
Sbjct: 13 HSLNLLNKIQNMKELAEMIDVVLTA--------EGEKFPCHRLVLAAFSPYFKAMFTCGL 64
Query: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFL 164
E Q V ++D+ AES VL++Y Y + ++ ANV+ + A+ +Q+E V C ++
Sbjct: 65 LECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Query: 165 ARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLA 224
+D +NC I FA G L +++ Y+ Q+F ++ S+ EE L ++ + Q L
Sbjct: 125 MDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEV----SLHEEIL-EIEVHQFLT 179
Query: 225 VLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLL-- 282
+++ D L++ E+++ + ++W+ + R E+ K VR + +L L
Sbjct: 180 LIKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVR---LELVNPSFLRQALRR 236
Query: 283 -TKPIVKKYCLDVIEGA-----------LQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSA 330
T + C+D+I+ A L +RYG L+ + N+SS S +
Sbjct: 237 NTMLLCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYG- 295
Query: 331 AENPPQRLGMCAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSP-------LTCLAHTRTVT 383
D C DP S Y + SP C
Sbjct: 296 -----------------------DASFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENN 332
Query: 384 TLAVCISPDHDIYLAAQPRTDLWVYK---PAQNSWQQLADRLLCREGMDVAYLNGYIYIL 440
T+ V L+ Q ++ +Y+ W++L RE + ++ +Y++
Sbjct: 333 TIIVAGEASAS-KLSRQKNKNVEIYRYHDRGNQFWEKLCTAEF-RELYALGSIHNDLYVI 390
Query: 441 GGRDPITGVKL--KEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALN-------- 490
GG+ I L V+ Y+V+R+ W V+PLP ++ + + LY +
Sbjct: 391 GGQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDL 450
Query: 491 --------SKRMFCYDPSHNMWLKCVSLKRNDFQ-EACVFNEEIYCICDI---------- 531
S ++ YDPS + W +K + ++ V N EIY + I
Sbjct: 451 PDEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQV 510
Query: 532 ----PVMKVYNPVRAEWRQMNNIP---LVSETNNYRIIKHGQKLLLITSRTPQWKKNRVT 584
V+++YNP WR+ +P L TN+ KL + + ++
Sbjct: 511 RKCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHGADRHEVIS 570
Query: 585 --VYEYDIRGDQWINIGTTLGLLQFDSNFFCLSARVYPSCLEPGQSFLTEE 633
+ E D +QW N+ + +L DS CL AR+ P L P S L EE
Sbjct: 571 KEILELDPWENQW-NV-VAINVLMHDSYDVCLVARMNPRDLIPPPSDLVEE 619
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 167 bits (424), Expect = 2e-41
Identities = 135/510 (26%), Positives = 234/510 (45%), Gaps = 65/510 (12%)
Query: 60 RLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDA 119
R LCDV + V G +++ +R +L+A PYF++MFTG + ES+Q V + D+D
Sbjct: 65 RELCDVVLVV-------GAKKIY-AHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDE 116
Query: 120 ESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKF 179
+ E+L+D+ YT ++++ E NV+ L A+ +LQL ++EAC FL R+LD +NC I F
Sbjct: 117 RAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAF 176
Query: 180 ADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTV 239
AD R+L A + NF+++ + E L QL+ ++ D L+V SE+ V
Sbjct: 177 ADTHSCRELLRIADKFTQHNFQEV-----MESEEFMLLPANQLIDIISSDELNVRSEEQV 231
Query: 240 CHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLL-TKPIVK--KYCLDVIE 296
+ + W++ + +ER P +V + VR + + +L G + + P++K + C D+++
Sbjct: 232 FNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPK---FLVGTVGSDPLIKSDEECRDLVD 288
Query: 297 GALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPF 356
A K+ + +P L+ P++ C + + G
Sbjct: 289 EA----------KNYLLLP-------QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDA 331
Query: 357 LCC----DPYSGDLYKVP--SPLTCLAHTRTVTTLAVCI-SPDHDIYLAAQPRTDLWVYK 409
+ DP + + V S C + L + D YL + R Y
Sbjct: 332 ISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVER-----YD 386
Query: 410 PAQNSW-QQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVA 468
P N W +A CR + VA L G++Y +GG+D ++ + + VE Y+ K N+W VA
Sbjct: 387 PKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNI--VERYDPKENKWTRVA 444
Query: 469 PLPHSFLSFDLMVIRDYLYALNS-------KRMFCYDPSHNMWLKCVSL-KRNDFQEACV 520
+ L + V+ +LYA+ + Y+P N W + R V
Sbjct: 445 SMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAV 504
Query: 521 FNEEIYCI------CDIPVMKVYNPVRAEW 544
+ + IY + ++ + YNP +W
Sbjct: 505 YQDMIYAVGGRDDTTELSSAERYNPRTNQW 534
Score = 58.9 bits (141), Expect = 1e-08
Identities = 45/179 (25%), Positives = 77/179 (43%), Gaps = 23/179 (12%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P +N W ++A R G+ VA L G++Y +GG D + L VE YN + N+W +
Sbjct: 433 YDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS--PLNTVERYNPQENRWHTI 490
Query: 468 APLPHSFLSFDLMVIRDYLYALNSK-------RMFCYDPSHNMWLKCVSL-KRNDFQEAC 519
AP+ V +D +YA+ + Y+P N W V++ R
Sbjct: 491 APMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLA 550
Query: 520 VFNEEIYCI------CDIPVMKVYNPVRAEWRQMNNIPLVSETNNYRIIKHGQKLLLIT 572
V N ++ + + ++V++P WR + NYR + G ++ +T
Sbjct: 551 VVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGM-------NYRRLGGGVGVIKMT 602
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 159 bits (403), Expect = 6e-39
Identities = 131/482 (27%), Positives = 209/482 (43%), Gaps = 45/482 (9%)
Query: 82 FPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANV 141
F C+R VLAAA YF++MF + E + + + VDAE+ L+DY YT + +++ NV
Sbjct: 83 FSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNV 142
Query: 142 ERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFK 201
+R+ A+++ Q + +ACASFL L+ NC IL+ AD L+ Q QSYI QNF
Sbjct: 143 QRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFV 202
Query: 202 QLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEV 261
Q+ + E DL + L +L+ D L V E V + W+ P ER V
Sbjct: 203 QI-----LNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYV 257
Query: 262 FKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSS 321
+ VR + ++E + P++++ C +V + R L
Sbjct: 258 LENVRLPLL--DPWYFVETVEADPLIRQ-CPEVFPLLQEARMYHL--------------- 299
Query: 322 SSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFL----CCDPYSG---DLYKVPSPLT 374
S N ++S P M+I + F+ C DP ++ K+P
Sbjct: 300 -SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEH 358
Query: 375 CLAHTRTVTTLAVCISPDHDIYLAAQPRT--DLWVYKPAQNSWQQLADRLLCREGMDVAY 432
L C++ +++Y++ T D+W Y + N W Q+ + R +
Sbjct: 359 ELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVV 418
Query: 433 LNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYA---- 488
L G +Y++GG D + ++ VE Y+ N W+ APL SF + LY
Sbjct: 419 LGGKVYVIGGFDGLQ--RINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGG 476
Query: 489 ----LNSKRMFCYDPSHNMW-LKCVSLKRNDFQEACVFNEEIYCICD-IPVMKVYNPVRA 542
L + + CYDPS N W LK A F + IY + + + Y+P+
Sbjct: 477 PNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLED 536
Query: 543 EW 544
W
Sbjct: 537 SW 538
Score = 32.7 bits (73), Expect = 1.1
Identities = 23/89 (25%), Positives = 36/89 (40%), Gaps = 1/89 (1%)
Query: 395 IYLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEV 454
IY+ L+ Y P ++SW + R +A N +YI GGRD V + V
Sbjct: 518 IYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEV-IATV 576
Query: 455 ECYNVKRNQWALVAPLPHSFLSFDLMVIR 483
C++ + + LP + IR
Sbjct: 577 LCWDPEAQKLTEECVLPRGVSHHGSVTIR 605
Score = 31.6 bits (70), Expect = 2.5
Identities = 27/142 (19%), Positives = 49/142 (34%), Gaps = 26/142 (18%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P+ N W A + + ++ IY++GG ++ + Y+ + W LV
Sbjct: 489 YDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGA-------MRALYAYSPLEDSWCLV 541
Query: 468 APLPHSFLSFDLMVIRDYLYALNSK--------RMFCYDPSHNMWLKCVSLKRNDFQEAC 519
L H S + + LY + + C+DP + E C
Sbjct: 542 TQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDP-----------EAQKLTEEC 590
Query: 520 VFNEEIYCICDIPVMKVYNPVR 541
V + + + K Y +R
Sbjct: 591 VLPRGVSHHGSVTIRKSYTHIR 612
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 155 bits (391), Expect = 1e-37
Identities = 145/538 (26%), Positives = 233/538 (43%), Gaps = 85/538 (15%)
Query: 43 TAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTG 102
++H+ +L F D+RL DV I V G+ FPC+R VL+A YF++MF
Sbjct: 46 SSHAENILQIFNEFRDSRLFTDVIICV--------EGKEFPCHRAVLSACSSYFRAMFCN 97
Query: 103 GMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACAS 162
ES++ V ++ + AE+ E + Y YTG+V ++ NV+ L+ S + Q+ +R+ACA
Sbjct: 98 DHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAK 157
Query: 163 FLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQL 222
FL +LD NC I +FAD + L ++ +++ Q F+ +S + E +L +L
Sbjct: 158 FLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVS-----QHEEFLELDKDEL 212
Query: 223 LAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVR--------WMHFTEED 274
+ + D L + E+ V ++W+ A R P E+ VR ++ E D
Sbjct: 213 IDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVD 272
Query: 275 QDYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENP 334
Q L+ C ++ A RY L + + P S+ S +V
Sbjct: 273 Q-----LIQN---SPECYQLLHEA--RRYHILGNEMMSPRTRPRRSTGYSEVIVV----- 317
Query: 335 PQRLGMCAKEMVIFFGHPRDPFLCCDPYSGD---LYKVPSPLTCLAHTRTVTTLAVCISP 391
+G C E V F P C DP +G+ L K+P T + AVC
Sbjct: 318 ---VGGC--ERVGGFNLPYTE--CYDPVTGEWKSLAKLPE--------FTKSEYAVCALR 362
Query: 392 DHDIYLAAQPRT-DLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVK 450
+ + + + D+W+Y N W ++A R +A L G +Y++GG D +
Sbjct: 363 NDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQN--R 420
Query: 451 LKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALN--------SKRMFCYDPSHN 502
L VECY+ N+W VAPL + S + L+ + S ++ YDP N
Sbjct: 421 LSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETN 480
Query: 503 MWL---------KCVSL--KRNDFQEACVFNEEIYCICDIPVMKVYNPVRAEWRQMNN 549
WL +C++ N A + IYC Y+PV W + N
Sbjct: 481 SWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYC---------YDPVEDYWMHVQN 529
Score = 38.5 bits (88), Expect = 0.020
Identities = 25/97 (25%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Query: 389 ISPDHDIYLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITG 448
+S ++ IY+A ++ Y P ++ W + + +E ++ NG IYILGGR G
Sbjct: 498 VSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRE-NG 556
Query: 449 VKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDY 485
+ CY+ + VA +P + I Y
Sbjct: 557 EATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRY 593
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 146 bits (369), Expect = 5e-35
Identities = 127/484 (26%), Positives = 204/484 (42%), Gaps = 59/484 (12%)
Query: 43 TAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTG 102
++++ ++L L RL DV + R FPC+R VLAA YF++MF+G
Sbjct: 26 SSYADSVLTHLNLLRQQRLFTDVLLHA--------GNRTFPCHRAVLAACSRYFEAMFSG 77
Query: 103 GMYESQQASVTM-HDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACA 161
G+ ESQ + V + + E E+L+DY Y+ RV ++E N E L A DML+ + +R+ACA
Sbjct: 78 GLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACA 137
Query: 162 SFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQ 221
FL + L TNC +L +DA KL + NF+ + + E L
Sbjct: 138 EFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIR-----KNEDFLQLPQDM 192
Query: 222 LLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTE---EDQDYL 278
++ +L + L+ E E+ V A+ W+ K+R E+ + VR + +
Sbjct: 193 VVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAM 252
Query: 279 EGLLTKPIVKKYCL-DVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQR 337
E L+TK K + + I L++ D + SL P + + + +
Sbjct: 253 EELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYL 312
Query: 338 LGMCAKEMV--IFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDI 395
+ AKE++ PR F C + C + +S
Sbjct: 313 VDQKAKEIIPKADIPSPRKEFSAC------------AIGCKVYITGGRGSENGVS----- 355
Query: 396 YLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITG------- 448
D+WVY W + A L+ R G A L +Y++GG TG
Sbjct: 356 -------KDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPS 408
Query: 449 VKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNS--------KRMFCYDPS 500
V LK+VE Y+ N+W +VAPL + ++ + L+A ++ CYD
Sbjct: 409 VSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQC 468
Query: 501 HNMW 504
N W
Sbjct: 469 ENRW 472
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 145 bits (367), Expect = 9e-35
Identities = 139/525 (26%), Positives = 223/525 (42%), Gaps = 56/525 (10%)
Query: 44 AHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGG 103
AH + +LLCDV I +R VLAA PYF +MFTG
Sbjct: 31 AHMGKAFKVMNELRSKQLLCDVMIVAEDVE--------IEAHRVVLAACSPYFCAMFTGD 82
Query: 104 MYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASF 163
M ES+ + + DVD ++ L+DY YT + ++E NV+ L A+ +LQL VR+ C F
Sbjct: 83 MSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDF 142
Query: 164 LARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLL 223
L +L TNC I FAD L QA +Y Q+F ++ + EE L+ L+L Q+
Sbjct: 143 LQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEV----MLGEEFLS-LSLDQVC 197
Query: 224 AVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLT 283
+++ D L V SE+ V + W+ + R A++ + VR +DYL +
Sbjct: 198 SLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVR---LPLLPRDYLVQTVE 254
Query: 284 KPIVKK---YCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGM 340
+ + K C D + A++ L + L+ P + P+
Sbjct: 255 EEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTK----------------PRTPVS 298
Query: 341 CAKEMVIFFGHPRDPF--LCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLA 398
K M++ G + C + D + + L V +A + +
Sbjct: 299 LPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGS 358
Query: 399 AQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYN 458
+ RT + VY ++ W +A R + A LN +Y +GG D TG L VE Y+
Sbjct: 359 LRVRT-VDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTG--LASVEAYS 415
Query: 459 VKRNQWALVAPLPHSFLSFDLMVIRDYLYALNS---------KRMFCYDPSHNMWLKCVS 509
K N+W VAP+ S + V+ LYA+ + Y+P+ N W+
Sbjct: 416 YKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVAD 475
Query: 510 LK-RNDFQEACVFNEEIYCI--CDIPVMK----VYNPVRAEWRQM 547
+ R V + ++Y D P+++ VY+P W+Q+
Sbjct: 476 MSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQV 520
Score = 55.5 bits (132), Expect = 2e-07
Identities = 42/153 (27%), Positives = 63/153 (41%), Gaps = 18/153 (11%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y N W +A R + V + G +Y +GG D + L VE YN N+W V
Sbjct: 414 YSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYV 473
Query: 468 APLPHSFLSFDLMVIRDYLYA-------LNSKRMFCYDPSHNMWLKCVSL---KRNDFQE 517
A + + V+ LYA L K + YDP N W + + +RN
Sbjct: 474 ADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRN--AG 531
Query: 518 ACVFNEEIYCI------CDIPVMKVYNPVRAEW 544
C N +Y + C++ ++ YNPV +W
Sbjct: 532 VCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
Score = 53.1 bits (126), Expect = 8e-07
Identities = 25/66 (37%), Positives = 37/66 (56%), Gaps = 2/66 (3%)
Query: 402 RTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKR 461
R + VY P N+W+Q+AD +CR V +NG +Y++GG D L VE YN
Sbjct: 504 RKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDD--GSCNLASVEYYNPVT 561
Query: 462 NQWALV 467
++W L+
Sbjct: 562 DKWTLL 567
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 144 bits (364), Expect = 2e-34
Identities = 126/492 (25%), Positives = 219/492 (44%), Gaps = 67/492 (13%)
Query: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGM 104
H+ +LAQ+ + + CDV ++V F +R VLAA+ PYF ++FTGGM
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQES--------FKAHRLVLAASSPYFAALFTGGM 70
Query: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFL 164
ES + V + ++A F++L+D+ YTG V++ NV+ L A+DMLQL V C FL
Sbjct: 71 KESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFL 130
Query: 165 ARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLA 224
++D NC I +F++ L +++YI +F ++ H G EE LA LT QL+
Sbjct: 131 KGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEV-HSG---EEFLA-LTKDQLIK 185
Query: 225 VLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRW--------MHFTEEDQD 276
+LR + L +E E V A+QW+ +R EV +R+ + + E D
Sbjct: 186 ILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSD 245
Query: 277 YLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSS--------------- 321
+ + + ++K+YC +V + + ++ L S V P +
Sbjct: 246 FNLRVALQTLLKEYC-EVCKSPKENKFCSFLQTSKVR-PRKKARKYLYAVGGYTRLQGGR 303
Query: 322 -SSSNSL---------------VSAAENPPQRLGMCA-KEMVIFFGHPRDPFL-----CC 359
S S +L VS+ LG+ MV G +D + C
Sbjct: 304 WSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECY 363
Query: 360 DPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDI--YLAAQPRTDLWVYKPAQNSWQQ 417
DP + V S + H R + VC + + ++ A+ + + P +N W+
Sbjct: 364 DPVTKQWTTVAS----MNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEV 419
Query: 418 LADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSF 477
+ + + R + G IY++GG G++L+ E Y+ +W+ + P+
Sbjct: 420 VGNMAVSRYYFGCCEMQGLIYVIGGISN-EGIELRSFEVYDPLSKRWSPLPPMGTRRAYL 478
Query: 478 DLMVIRDYLYAL 489
+ + D +Y++
Sbjct: 479 GVAALNDCIYSV 490
Score = 36.2 bits (82), Expect = 0.10
Identities = 20/61 (32%), Positives = 29/61 (47%), Gaps = 4/61 (6%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGR----DPITGVKLKEVECYNVKRNQ 463
Y + W ++A + R GM V +NG +Y+ GGR D + L VE YN +
Sbjct: 506 YSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDT 565
Query: 464 W 464
W
Sbjct: 566 W 566
Score = 33.5 bits (75), Expect = 0.66
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 1/81 (1%)
Query: 407 VYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWAL 466
VY P W L R + VA LN IY +GG + T L VE Y+ + +W
Sbjct: 457 VYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNE-TQDALHTVEKYSFEEEKWVE 515
Query: 467 VAPLPHSFLSFDLMVIRDYLY 487
VA + ++ + LY
Sbjct: 516 VASMKVPRAGMCVVAVNGLLY 536
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 144 bits (364), Expect = 2e-34
Identities = 126/492 (25%), Positives = 219/492 (44%), Gaps = 67/492 (13%)
Query: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGM 104
H+ +LAQ+ + + CDV ++V F +R VLAA+ PYF ++FTGGM
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQES--------FKAHRLVLAASSPYFAALFTGGM 70
Query: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFL 164
ES + V + ++A F++L+D+ YTG V++ NV+ L A+DMLQL V C FL
Sbjct: 71 KESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFL 130
Query: 165 ARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLA 224
++D NC I +F++ L +++YI +F ++ H G EE LA LT QL+
Sbjct: 131 KGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEV-HSG---EEFLA-LTKDQLIK 185
Query: 225 VLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRW--------MHFTEEDQD 276
+LR + L +E E V A+QW+ +R EV +R+ + + E D
Sbjct: 186 ILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSD 245
Query: 277 YLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSS--------------- 321
+ + + ++K+YC +V + + ++ L S V P +
Sbjct: 246 FNLRVALQTLLKEYC-EVCKSPKENKFCSFLQTSKVR-PRKKARKYLYAVGGYTRLQGGR 303
Query: 322 -SSSNSL---------------VSAAENPPQRLGMCA-KEMVIFFGHPRDPFL-----CC 359
S S +L VS+ LG+ MV G +D + C
Sbjct: 304 WSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECY 363
Query: 360 DPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDI--YLAAQPRTDLWVYKPAQNSWQQ 417
DP + V S + H R + VC + + ++ A+ + + P +N W+
Sbjct: 364 DPVTKQWTTVAS----MNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEV 419
Query: 418 LADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSF 477
+ + + R + G IY++GG G++L+ E Y+ +W+ + P+
Sbjct: 420 VGNMAVSRYYFGCCEMQGLIYVIGGISN-EGIELRSFEVYDPLSKRWSPLPPMGTRRAYL 478
Query: 478 DLMVIRDYLYAL 489
+ + D +Y++
Sbjct: 479 GVAALNDCIYSV 490
Score = 34.7 bits (78), Expect = 0.30
Identities = 17/57 (29%), Positives = 26/57 (45%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQW 464
Y + W ++A + R GM V +NG +Y+ GGR + Y V R +W
Sbjct: 506 YSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYEVFRLKW 562
Score = 33.5 bits (75), Expect = 0.66
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 1/81 (1%)
Query: 407 VYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWAL 466
VY P W L R + VA LN IY +GG + T L VE Y+ + +W
Sbjct: 457 VYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNE-TQDALHTVEKYSFEEEKWVE 515
Query: 467 VAPLPHSFLSFDLMVIRDYLY 487
VA + ++ + LY
Sbjct: 516 VASMKVPRAGMCVVAVNGLLY 536
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 141 bits (356), Expect = 2e-33
Identities = 138/582 (23%), Positives = 233/582 (40%), Gaps = 104/582 (17%)
Query: 35 TGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACP 94
T E + H+ +++++ + LCDV ++ G R P +R VL++
Sbjct: 146 TSDEFFQALNHAEQTFKKMENYLRHKQLCDV---ILVAGD-----RRIPAHRLVLSSVSD 197
Query: 95 YFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLE 154
YF +MFT + E++Q + M V+ S L+ Y YTGR+ L E N+E L + + +LQL
Sbjct: 198 YFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLS 257
Query: 155 YVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETL 214
V EAC FL ++L +NC I FADA G L A +Y ++F ++ IR +
Sbjct: 258 QVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEV-----IRNQEF 312
Query: 215 ADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRW------- 267
L +++ +L D +++ +E+T+ + + W+ ++R +++ +R
Sbjct: 313 VLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQF 372
Query: 268 -------------------------MHFTEEDQDYLEGLLTKP-------IVKKYCLDVI 295
H E + L+ TKP + +D
Sbjct: 373 LADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDST 432
Query: 296 EGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDP 355
+GA + DL PV N + + G+ + ++ RD
Sbjct: 433 KGATSIEKYDLRTNMWTPVANMNGRR--------------LQFGVAVLDDKLYVVGGRDG 478
Query: 356 FL------CCDPYSGDLYKVPSPLTCLAHTRTVTTL--AVCISPDHD--IYLAAQPRTDL 405
C +P + + V P++ H V L + HD YL R D
Sbjct: 479 LKTLNTVECYNPKT-KTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWD- 536
Query: 406 WVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWA 465
P W +A R + VA L+G +Y +GGRD + LK VEC++ N+W
Sbjct: 537 ----PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS--CLKSVECFDPHTNKWT 590
Query: 466 LVAPLPHSFLSFDLMVIRDYLYA----------LNSKRMFC---YDPSHNMWLKCVSLK- 511
L A + + LYA L S+ C YDP +MW S+
Sbjct: 591 LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSI 650
Query: 512 RNDFQEACVFNEEIYCI------CDIPVMKVYNPVRAEWRQM 547
D C+ +++Y + + ++ Y+P EW Q+
Sbjct: 651 SRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQV 692
Score = 55.1 bits (131), Expect = 2e-07
Identities = 51/211 (24%), Positives = 84/211 (39%), Gaps = 26/211 (12%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P +W + R G+ VA L G +Y +GG D + L VE ++ + QW V
Sbjct: 488 YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS--YLNTVERWDPQARQWNFV 545
Query: 468 APLPHSFLSFDLMVIRDYLYALNS-------KRMFCYDPSHNMWLKCVSL-KRNDFQEAC 519
A + + + V+ LYA+ K + C+DP N W C + KR
Sbjct: 546 ATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVT 605
Query: 520 VFNEEIYCI--CDIPVMKV----------YNPVRAEWRQMNNIPLVSETNNYRIIKHGQK 567
+N +Y I D P + Y+P W + ++ + + ++ G K
Sbjct: 606 TWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL--GDK 663
Query: 568 LLLITSRTPQWKKNRVTVYEYDIRGDQWINI 598
L + Q N TV YD + ++W +
Sbjct: 664 LYAVGGYDGQAYLN--TVEAYDPQTNEWTQV 692
Score = 40.8 bits (94), Expect = 0.004
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P + W +A + R+ + V L +Y +GG D L VE Y+ + N+W V
Sbjct: 635 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDG--QAYLNTVEAYDPQTNEWTQV 692
Query: 468 APL 470
APL
Sbjct: 693 APL 695
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 141 bits (356), Expect = 2e-33
Identities = 138/582 (23%), Positives = 233/582 (40%), Gaps = 104/582 (17%)
Query: 35 TGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACP 94
T E + H+ +++++ + LCDV ++ G R P +R VL++
Sbjct: 192 TSDEFFQALNHAEQTFKKMENYLRHKQLCDV---ILVAGD-----RRIPAHRLVLSSVSD 243
Query: 95 YFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLE 154
YF +MFT + E++Q + M V+ S L+ Y YTGR+ L E N+E L + + +LQL
Sbjct: 244 YFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLS 303
Query: 155 YVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETL 214
V EAC FL ++L +NC I FADA G L A +Y ++F ++ IR +
Sbjct: 304 QVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEV-----IRNQEF 358
Query: 215 ADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRW------- 267
L +++ +L D +++ +E+T+ + + W+ ++R +++ +R
Sbjct: 359 VLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQF 418
Query: 268 -------------------------MHFTEEDQDYLEGLLTKP-------IVKKYCLDVI 295
H E + L+ TKP + +D
Sbjct: 419 LADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDST 478
Query: 296 EGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDP 355
+GA + DL PV N + + G+ + ++ RD
Sbjct: 479 KGATSIEKYDLRTNMWTPVANMNGRR--------------LQFGVAVLDDKLYVVGGRDG 524
Query: 356 FL------CCDPYSGDLYKVPSPLTCLAHTRTVTTL--AVCISPDHD--IYLAAQPRTDL 405
C +P + + V P++ H V L + HD YL R D
Sbjct: 525 LKTLNTVECYNPKT-KTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWD- 582
Query: 406 WVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWA 465
P W +A R + VA L+G +Y +GGRD + LK VEC++ N+W
Sbjct: 583 ----PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS--CLKSVECFDPHTNKWT 636
Query: 466 LVAPLPHSFLSFDLMVIRDYLYA----------LNSKRMFC---YDPSHNMWLKCVSLK- 511
L A + + LYA L S+ C YDP +MW S+
Sbjct: 637 LCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSI 696
Query: 512 RNDFQEACVFNEEIYCI------CDIPVMKVYNPVRAEWRQM 547
D C+ +++Y + + ++ Y+P EW Q+
Sbjct: 697 SRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQV 738
Score = 55.1 bits (131), Expect = 2e-07
Identities = 51/211 (24%), Positives = 84/211 (39%), Gaps = 26/211 (12%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P +W + R G+ VA L G +Y +GG D + L VE ++ + QW V
Sbjct: 534 YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS--YLNTVERWDPQARQWNFV 591
Query: 468 APLPHSFLSFDLMVIRDYLYALNS-------KRMFCYDPSHNMWLKCVSL-KRNDFQEAC 519
A + + + V+ LYA+ K + C+DP N W C + KR
Sbjct: 592 ATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVT 651
Query: 520 VFNEEIYCI--CDIPVMKV----------YNPVRAEWRQMNNIPLVSETNNYRIIKHGQK 567
+N +Y I D P + Y+P W + ++ + + ++ G K
Sbjct: 652 TWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL--GDK 709
Query: 568 LLLITSRTPQWKKNRVTVYEYDIRGDQWINI 598
L + Q N TV YD + ++W +
Sbjct: 710 LYAVGGYDGQAYLN--TVEAYDPQTNEWTQV 738
Score = 40.8 bits (94), Expect = 0.004
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P + W +A + R+ + V L +Y +GG D L VE Y+ + N+W V
Sbjct: 681 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDG--QAYLNTVEAYDPQTNEWTQV 738
Query: 468 APL 470
APL
Sbjct: 739 APL 741
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 139 bits (350), Expect = 9e-33
Identities = 141/556 (25%), Positives = 232/556 (41%), Gaps = 58/556 (10%)
Query: 62 LCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAES 121
L DVT+ V GR PC+R +LA + PYF +MF G ES A V + DV+
Sbjct: 14 LADVTLLV--------GGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAV 65
Query: 122 FEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFAD 181
LVD+ YTGR+++++ NVE L + L V++ C +L ++LD NC I +F +
Sbjct: 66 VGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGE 125
Query: 182 AFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVCH 241
G + ++A +++ +NF+ ++ RE+ L +L+ L D L V+ EQ+
Sbjct: 126 QQGLLGVAAKAWAFLRENFEAVA-----REDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
Query: 242 VAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLL-TKPIVK-----KYCLDVI 295
++W+ P+ R E+ V H + ++ LL ++P+++ + L
Sbjct: 181 ALMRWVRHDPQARAAHLPELLSLV---HLDAVPRPCVQQLLASEPLIQESEACRAALSQG 237
Query: 296 EGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDP 355
+ L + LV V + A E P LG A F+
Sbjct: 238 HDGAPLALQQKLEEVLVVVGGQALEEE------EAGEEPTPGLGNFA-----FYNSKAKR 286
Query: 356 FLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSW 415
++ P D +K L L + VT + D T W + + SW
Sbjct: 287 WMAL-PDFPDYHKWGFSLAALNNNIYVTGGSRGTKTD------TWSTTQAWCFPLKEASW 339
Query: 416 QQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFL 475
+ +A L R A LNG IY++GG T + + EVE Y+ + W V+P
Sbjct: 340 KPVAPMLKPRTNHASAALNGEIYVIGG----TTLDVVEVESYDPYTDSWTPVSPALKYVS 395
Query: 476 SFDLMVIRDYLYAL-------NSKRMFCYDPSHNMWLKCVS---LKRNDFQEACVFNEEI 525
+F R LY + N+ + CY+P + W S K + E+
Sbjct: 396 NFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGEL 455
Query: 526 YCICD-IPVMKVYNPVRAEWRQMNNIPLVSETNNYRIIKHGQKLLLITSRTPQWKKN-RV 583
Y I D + VY+P W+++ + + E N ++ G L + R + + V
Sbjct: 456 YLIGDNTKKVYVYDPGANLWQKVQSQHSLHE--NGALVPLGDALYVTGGRWQGMEGDYHV 513
Query: 584 TVYEYDIRGDQWINIG 599
+ YD D W G
Sbjct: 514 EMEAYDTVRDTWTRHG 529
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/89 (26%), Positives = 40/89 (44%), Gaps = 1/89 (1%)
Query: 388 CISPDHDIYLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGR-DPI 446
C + ++YL ++VY P N WQ++ + E + L +Y+ GGR +
Sbjct: 448 CAALHGELYLIGDNTKKVYVYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGM 507
Query: 447 TGVKLKEVECYNVKRNQWALVAPLPHSFL 475
G E+E Y+ R+ W LP +L
Sbjct: 508 EGDYHVEMEAYDTVRDTWTRHGALPRLWL 536
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 139 bits (349), Expect = 1e-32
Identities = 119/526 (22%), Positives = 220/526 (41%), Gaps = 67/526 (12%)
Query: 41 KDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMF 100
KD+ H L ++FY L D+T++ + G +F C+R VLAA YFK+MF
Sbjct: 14 KDSTHPVDFLDAFRTFYLDGLFTDITLQCPS-------GIIFHCHRAVLAACSNYFKAMF 66
Query: 101 TGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREAC 160
T M E + + + + + E LV+Y YT ++ +++ NV+ L A+D+LQ V++AC
Sbjct: 67 TADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKAC 126
Query: 161 ASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLA 220
FL R LD+ NC + FA+ +L +++ + FK++ ++E +++L
Sbjct: 127 ERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEV-----WQQEEFLEISLE 181
Query: 221 QLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEG 280
+ L +L +L V E+ + ++W + R + + + D YL+
Sbjct: 182 KFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYIN----IDIDPVYLKT 237
Query: 281 LLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGM 340
L +++ CL + + L+Y +L P+ S S++ +
Sbjct: 238 ALG---LQRSCL-----LTENKIRSLIYNALNPMHKEISQRSTATMYIIGG--------- 280
Query: 341 CAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQ 400
++ HP DP + + + VT C+ P +IY+
Sbjct: 281 -------YYWHPLSEVHIWDPLTNVWIQGAEIPDYTRESYGVT----CLGP--NIYVTGG 327
Query: 401 PRTD-------LWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKE 453
RTD +W+Y + W + L R L G +Y LGG G +E
Sbjct: 328 YRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYR--KGAPAEE 385
Query: 454 VECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNS----------KRMFCYDPSHNM 503
E Y+ + +W +A + + V+ D +Y + ++ Y+ N
Sbjct: 386 AEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINE 445
Query: 504 WLKCVSLKRNDFQEACV-FNEEIYCI-CDIPVMKVYNPVRAEWRQM 547
W S ++ V F ++Y + + + Y+P + EWR++
Sbjct: 446 WSLITSSPHPEYGLCSVPFENKLYLVGGQTTITECYDPEQNEWREI 491
Score = 52.4 bits (124), Expect = 1e-06
Identities = 28/91 (30%), Positives = 44/91 (48%), Gaps = 1/91 (1%)
Query: 387 VCISP-DHDIYLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDP 445
+C P ++ +YL T Y P QN W+++A + R +NG IY+ GG
Sbjct: 459 LCSVPFENKLYLVGGQTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSY 518
Query: 446 ITGVKLKEVECYNVKRNQWALVAPLPHSFLS 476
G L+ +E Y+ N+W +V LP + S
Sbjct: 519 SKGTYLQSIEKYDPDLNKWEIVGNLPSAMRS 549
Score = 36.6 bits (83), Expect = 0.078
Identities = 24/106 (22%), Positives = 42/106 (39%), Gaps = 16/106 (15%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y N W + G+ +Y++GG+ IT ECY+ ++N+W +
Sbjct: 439 YNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTIT-------ECYDPEQNEWREI 491
Query: 468 APLPHSFLSFDLMVIRDYLYALN----SKRMFC-----YDPSHNMW 504
AP+ + +++ +Y SK + YDP N W
Sbjct: 492 APMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW 537
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 138 bits (348), Expect = 1e-32
Identities = 129/499 (25%), Positives = 210/499 (42%), Gaps = 83/499 (16%)
Query: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGM 104
HS LL L LCD+ + V G ++ ++ VLA+ PYFK+MFTG +
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRV-------GDVKIH-AHKVVLASVSPYFKAMFTGNL 68
Query: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFL 164
E + + V +D + + +V+Y YTG V +S+ VE L A+++LQ++ V + C +FL
Sbjct: 69 SEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFL 128
Query: 165 ARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLA 224
+LD NC I +FA+ +G R L A YI QNF+ + + E +LT A L
Sbjct: 129 ESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAV-----CQTEEFFELTHADLDE 183
Query: 225 VLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTK 284
++ D L+V +E+TV + W++ +ER A++ VR
Sbjct: 184 IVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVR-----------------L 226
Query: 285 PIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLG----- 339
P+ L +++ LY++ + + + N + P RL
Sbjct: 227 PL------------LSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVL 274
Query: 340 ----MCAKEMVIFFGHPRDPFLCCDPY-----SGDLYKVPSPLTCLAHTRTVTTLAVCIS 390
CA +++ G F C D D + +PL + +C+
Sbjct: 275 MTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRY-----EFGICVL 329
Query: 391 PDHDIY----LAAQPRTDLWVYK---------PAQNSWQQLADRLLCREGMDVAYLNGYI 437
D +Y +A R + + K P N+W L R + V L G +
Sbjct: 330 -DQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGEL 388
Query: 438 YILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYAL------NS 491
Y LGG D + L+ VE Y K +W VAP+ + F V+ +YA+ +
Sbjct: 389 YALGGYDGQS--YLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHM 446
Query: 492 KRMFCYDPSHNMWLKCVSL 510
+ YDPS + W S+
Sbjct: 447 NSVERYDPSKDSWEMVASM 465
Score = 51.6 bits (122), Expect = 2e-06
Identities = 32/130 (24%), Positives = 56/130 (43%), Gaps = 23/130 (17%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P+++SW+ +A R V + G+I+++GG + ++ L +E Y+ +NQW +
Sbjct: 452 YDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS--HLSSIERYDPHQNQWTVC 509
Query: 468 APLPHSFLSFDLMVIRDYLYALNS-------KRMFCYDPSHNMWLKCVSLKRNDFQEACV 520
P+ VI +YLY + + YDP + WL +
Sbjct: 510 RPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM---------- 559
Query: 521 FNEEIYCICD 530
IYC C+
Sbjct: 560 ----IYCRCN 565
Score = 50.4 bits (119), Expect = 5e-06
Identities = 35/151 (23%), Positives = 61/151 (40%), Gaps = 17/151 (11%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P WQ +A R A L+G IY +GG P + VE Y+ ++ W +V
Sbjct: 406 YIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGP---AHMNSVERYDPSKDSWEMV 462
Query: 468 APLPHSFLSFDLMVIRDYLYALNS-------KRMFCYDPSHNMWLKCVSLKR-NDFQEAC 519
A + + F + V+ +++ + + YDP N W C +K A
Sbjct: 463 ASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAA 522
Query: 520 VFNEEIYCI------CDIPVMKVYNPVRAEW 544
V + +Y + + ++ Y+P+ W
Sbjct: 523 VIDNYLYVVGGHSGSSYLNTVQKYDPISDTW 553
Score = 31.2 bits (69), Expect = 3.3
Identities = 19/75 (25%), Positives = 33/75 (44%), Gaps = 2/75 (2%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P QN W R G+ A ++ Y+Y++GG + L V+ Y+ + W
Sbjct: 499 YDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSS--YLNTVQKYDPISDTWLDS 556
Query: 468 APLPHSFLSFDLMVI 482
A + + +F L +
Sbjct: 557 AGMIYCRCNFGLTAL 571
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 135 bits (340), Expect = 1e-31
Identities = 121/468 (25%), Positives = 206/468 (44%), Gaps = 49/468 (10%)
Query: 53 LKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASV 112
L FY+ LCDVT++V GS +L C++ VLA PYF++MF M E++Q +
Sbjct: 57 LLRFYENGELCDVTLKV---GS-----KLISCHKLVLACVIPYFRAMFLSEMAEAKQTLI 108
Query: 113 TMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTN 172
+ D D ++ E LV + Y+ R++L+ NV+ L A+ +LQ+E V AC ++ +N
Sbjct: 109 EIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSN 168
Query: 173 CTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLD 232
C A+ FA++ L A Y +F ++ + E ++ L +L L+
Sbjct: 169 CLAVRAFAESHNRIDLMDMADQYACDHFTEV-----VECEDFVSVSPQHLHKLLSSSDLN 223
Query: 233 VESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKY-- 290
+E+E+ V + A++WL A P+ E VR D+L G++ K + K
Sbjct: 224 IENEKQVYNAAIKWLLANPQHHSKWLDETLAQVR---LPLLPVDFLMGVVAKEQIVKQNL 280
Query: 291 -CLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFF 349
C D+++ A L+ S VP+ S ++ P++ V
Sbjct: 281 KCRDLLDEARNYH----LHLSSRAVPDFEYSIRTT----------PRKHTAGVLFCVGGR 326
Query: 350 GHPRDPFLCCDPYS---GDLYKVPSPLTCLAHTRTVTTLA-VCISPDHDIYLAAQPRTDL 405
G DPF + YS + P + H ++ V HD + +
Sbjct: 327 GGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHD---GNEHLGSM 383
Query: 406 WVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWA 465
++ P N W A R G+ +A L G IY +GG D T +VE Y+++ +QW+
Sbjct: 384 EMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT--CFNDVERYDIESDQWS 441
Query: 466 LVAPLPHSFLSFDLMVIRDYLYALNSKRMFC-------YDPSHNMWLK 506
VAP+ + + +++YA+ YDP + W++
Sbjct: 442 TVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIE 489
Score = 38.5 bits (88), Expect = 0.020
Identities = 26/104 (25%), Positives = 45/104 (43%), Gaps = 9/104 (8%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P + W ++ + R G V+ L+G +Y++GG D L VE Y+ + N+W V
Sbjct: 480 YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFD--DNSPLSSVERYDPRSNKWDYV 537
Query: 468 APLPHSFLSFDLMVIRDYLYALNS-------KRMFCYDPSHNMW 504
A L + + ++A+ + +DP N W
Sbjct: 538 AALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRW 581
Score = 38.1 bits (87), Expect = 0.027
Identities = 21/72 (29%), Positives = 34/72 (47%), Gaps = 2/72 (2%)
Query: 401 PRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVK 460
P + + Y P N W +A R G+ +A + G I+ +GG + L VE ++
Sbjct: 520 PLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHN--GNAYLNTVEAFDPV 577
Query: 461 RNQWALVAPLPH 472
N+W LV + H
Sbjct: 578 LNRWELVGSVSH 589
Score = 32.7 bits (73), Expect = 1.1
Identities = 18/83 (21%), Positives = 36/83 (43%), Gaps = 8/83 (9%)
Query: 435 GYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSK-- 492
G ++ +GGR +G + +ECY++ +N W + ++ + +YA+
Sbjct: 318 GVLFCVGGRGG-SGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDG 376
Query: 493 -----RMFCYDPSHNMWLKCVSL 510
M +DP N W+ S+
Sbjct: 377 NEHLGSMEMFDPLTNKWMMKASM 399
Score = 30.0 bits (66), Expect = 7.3
Identities = 24/108 (22%), Positives = 40/108 (37%), Gaps = 9/108 (8%)
Query: 404 DLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQ 463
D+ Y + W +A R G+ L ++Y +GG D + L VE Y+ ++
Sbjct: 429 DVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGM--ASLSSVERYDPHLDK 486
Query: 464 WALVAPLPHSFLSFDLMVIRDYLYALNS-------KRMFCYDPSHNMW 504
W V + + + LY + + YDP N W
Sbjct: 487 WIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKW 534
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 135 bits (340), Expect = 1e-31
Identities = 128/568 (22%), Positives = 235/568 (41%), Gaps = 75/568 (13%)
Query: 37 PEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYF 96
P+++ H+ ++L + S + LCDVT+ V FP +R VLAA YF
Sbjct: 7 PKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKD--------FPAHRIVLAACSDYF 58
Query: 97 KSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYV 156
+MFT + E + V + + A + E+L+D+ YT V ++ NV+ L A+ +LQL+ V
Sbjct: 59 CAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGV 118
Query: 157 REACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLAD 216
++AC FL +LD +NC I FA+ L A+ + ++F ++ ++ E
Sbjct: 119 KQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEV-----VQHEEFIL 173
Query: 217 LTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQD 276
L+ ++ +++ D + V+SE+ V + W++ A KER S + + VR T
Sbjct: 174 LSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPR--- 230
Query: 277 YLEGLL-TKPIVK--KYCLDVIEGALQMRYGDLLYKSL--------------VPVPNSSS 319
Y+ ++ +P ++ C D+++ A + L + + V
Sbjct: 231 YITDVIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFG 290
Query: 320 SSSSSNSLVSAAENPPQR----------------LGMCAKEMVI--FFGHPRDPFLCCDP 361
S S +V + Q + + + VI + G R + C
Sbjct: 291 SQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLD 350
Query: 362 YSGD---LYKVPSPLTCLAHTRTVTTLA--VCISPDHDIYLAAQPRTDLWVYKPAQNSWQ 416
Y+ D ++ +P+ TTL + +S D ++ T + Y P + W
Sbjct: 351 YTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFD---GSRRHTSMERYDPNIDQWS 407
Query: 417 QLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLS 476
L D REG + +G IY LGG D + L VE Y+ W V P+
Sbjct: 408 MLGDMQTAREGAGLVVASGVIYCLGGYDGLN--ILNSVEKYDPHTGHWTNVTPMATKRSG 465
Query: 477 FDLMVIRDYLYALNS-------KRMFCYDPSHNMWLKCVSLKR-NDFQEACVFNEEIYCI 528
+ ++ D++Y + + Y+ + W S+ + A V +Y I
Sbjct: 466 AGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAI 525
Query: 529 CD------IPVMKVYNPVRAEWRQMNNI 550
+ ++ Y+P+ W + ++
Sbjct: 526 AGYDGNSLLSSIECYDPIIDSWEVVTSM 553
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 132 bits (333), Expect = 8e-31
Identities = 128/531 (24%), Positives = 212/531 (39%), Gaps = 96/531 (18%)
Query: 86 RNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLY 145
R VL++ YF +MFT + E++Q + M V+ S L+ Y YTGR+ L E N+E L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 146 AASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSH 205
+ + +LQL V EAC FL ++L +NC I FADA G L A +Y ++F ++
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEV-- 291
Query: 206 MGSIREETLADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCV 265
IR + L +++ +L D +++ +E+T+ + + W+ ++R +++ +
Sbjct: 292 ---IRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYI 348
Query: 266 RW--------------------------------MHFTEEDQDYLEGLLTKP-------I 286
R H E + L+ TKP +
Sbjct: 349 RLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTL 408
Query: 287 VKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMV 346
+D +GA + DL PV N + + G+ +
Sbjct: 409 FAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRR--------------LQFGVAVLDDK 454
Query: 347 IFFGHPRDPFL------CCDPYSGDLYKVPSPLTCLAHTRTVTTL--AVCISPDHD--IY 396
++ RD C +P + + V P++ H V L + HD Y
Sbjct: 455 LYVVGGRDGLKTLNTVECYNPKT-KTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSY 513
Query: 397 LAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVEC 456
L R D P W +A R + VA L+G +Y +GGRD + LK VEC
Sbjct: 514 LNTVERWD-----PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS--CLKSVEC 566
Query: 457 YNVKRNQWALVAPLPHSFLSFDLMVIRDYLYA----------LNSKRMFC---YDPSHNM 503
++ N+W L A + + LYA L S+ C YDP +M
Sbjct: 567 FDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDM 626
Query: 504 WLKCVSLK-RNDFQEACVFNEEIYCI------CDIPVMKVYNPVRAEWRQM 547
W S+ D C+ +++Y + + ++ Y+P EW Q+
Sbjct: 627 WTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQV 677
Score = 55.1 bits (131), Expect = 2e-07
Identities = 51/211 (24%), Positives = 84/211 (39%), Gaps = 26/211 (12%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P +W + R G+ VA L G +Y +GG D + L VE ++ + QW V
Sbjct: 473 YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS--YLNTVERWDPQARQWNFV 530
Query: 468 APLPHSFLSFDLMVIRDYLYALNS-------KRMFCYDPSHNMWLKCVSL-KRNDFQEAC 519
A + + + V+ LYA+ K + C+DP N W C + KR
Sbjct: 531 ATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVT 590
Query: 520 VFNEEIYCI--CDIPVMKV----------YNPVRAEWRQMNNIPLVSETNNYRIIKHGQK 567
+N +Y I D P + Y+P W + ++ + + ++ G K
Sbjct: 591 TWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLL--GDK 648
Query: 568 LLLITSRTPQWKKNRVTVYEYDIRGDQWINI 598
L + Q N TV YD + ++W +
Sbjct: 649 LYAVGGYDGQAYLN--TVEAYDPQTNEWTQV 677
Score = 40.8 bits (94), Expect = 0.004
Identities = 21/63 (33%), Positives = 31/63 (49%), Gaps = 2/63 (3%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P + W +A + R+ + V L +Y +GG D L VE Y+ + N+W V
Sbjct: 620 YDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDG--QAYLNTVEAYDPQTNEWTQV 677
Query: 468 APL 470
APL
Sbjct: 678 APL 680
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 132 bits (331), Expect = 1e-30
Identities = 133/515 (25%), Positives = 221/515 (42%), Gaps = 70/515 (13%)
Query: 61 LLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
LLCDVTI +R VLAA PYF +MFTG M ES+ V + +VD
Sbjct: 58 LLCDVTIVA--------EDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 109
Query: 121 SFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
+ +L+DY YT + ++E NV+ L A+ +LQL+ V++ C FL +L NC I FA
Sbjct: 110 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 169
Query: 181 DAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVC 240
D L ++A +Y Q+F AD+ L++ + L++ EQ
Sbjct: 170 DMHACTDLLNKANTYAEQHF--------------ADVVLSE-------EFLNLGIEQVCS 208
Query: 241 HVAVQWLEAAPKERGPSAAEVFKCV-RWM-HFTEEDQDYLEGLLTK---PIV-KKYCLDV 294
++ L + +E+ VF+ V W+ H + Q+++ L+ P++ ++Y +
Sbjct: 209 LISSDKLTISSEEK------VFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQR 262
Query: 295 IEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRD 354
+E ++ L+ + L+ + + K MV+ G
Sbjct: 263 VEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPK 322
Query: 355 PFLCCDPYS------GDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVY 408
+ Y + ++PS C A + L + + + + RT + Y
Sbjct: 323 AIRSVECYDFKEERWHQVAELPSR-RCRAGMVYMAGLVFAVGGFNG---SLRVRT-VDSY 377
Query: 409 KPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVA 468
P ++ W +A+ R + A LNG +Y +GG D TG L VE YN+K N+W VA
Sbjct: 378 DPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG--LSSVEAYNIKSNEWFHVA 435
Query: 469 PLPHSFLSFDLMVIRDYLYALNS---------KRMFCYDPSHNMWLKCVSLK-RNDFQEA 518
P+ S + V+ LYA+ + CY+ + N W + R
Sbjct: 436 PMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGV 495
Query: 519 CVFNEEIYCI--CDIPVMK----VYNPVRAEWRQM 547
V N +Y + D P+++ VY+P WRQ+
Sbjct: 496 GVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQV 530
Score = 63.2 bits (152), Expect = 8e-10
Identities = 40/153 (26%), Positives = 65/153 (42%), Gaps = 18/153 (11%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y N W +A R + V + G +Y +GG D + L VECYN N+W +
Sbjct: 424 YNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYI 483
Query: 468 APLPHSFLSFDLMVIRDYLYALNS-------KRMFCYDPSHNMWLKCVSL---KRNDFQE 517
A + + V+ + LYA+ K + YDP+ N W + + +RN
Sbjct: 484 AEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRN--AG 541
Query: 518 ACVFNEEIYCI------CDIPVMKVYNPVRAEW 544
C N +Y + C++ ++ YNP +W
Sbjct: 542 VCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 574
Score = 53.9 bits (128), Expect = 5e-07
Identities = 25/67 (37%), Positives = 38/67 (56%), Gaps = 2/67 (2%)
Query: 402 RTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKR 461
R + VY P N+W+Q+AD +CR V +NG +Y++GG D L VE YN
Sbjct: 514 RKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDD--GSCNLASVEYYNPTT 571
Query: 462 NQWALVA 468
++W +V+
Sbjct: 572 DKWTVVS 578
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 132 bits (331), Expect = 1e-30
Identities = 133/515 (25%), Positives = 221/515 (42%), Gaps = 70/515 (13%)
Query: 61 LLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
LLCDVTI +R VLAA PYF +MFTG M ES+ V + +VD
Sbjct: 54 LLCDVTIVA--------EDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 105
Query: 121 SFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
+ +L+DY YT + ++E NV+ L A+ +LQL+ V++ C FL +L NC I FA
Sbjct: 106 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 165
Query: 181 DAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVC 240
D L ++A +Y Q+F AD+ L++ + L++ EQ
Sbjct: 166 DMHACTDLLNKANTYAEQHF--------------ADVVLSE-------EFLNLGIEQVCS 204
Query: 241 HVAVQWLEAAPKERGPSAAEVFKCV-RWM-HFTEEDQDYLEGLLTK---PIV-KKYCLDV 294
++ L + +E+ VF+ V W+ H + Q+++ L+ P++ ++Y +
Sbjct: 205 LISSDKLTISSEEK------VFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQR 258
Query: 295 IEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRD 354
+E ++ L+ + L+ + + K MV+ G
Sbjct: 259 VEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPK 318
Query: 355 PFLCCDPYS------GDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVY 408
+ Y + ++PS C A + L + + + + RT + Y
Sbjct: 319 AIRSVECYDFKEERWHQVAELPSR-RCRAGMVYMAGLVFAVGGFNG---SLRVRT-VDSY 373
Query: 409 KPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVA 468
P ++ W +A+ R + A LNG +Y +GG D TG L VE YN+K N+W VA
Sbjct: 374 DPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG--LSSVEAYNIKSNEWFHVA 431
Query: 469 PLPHSFLSFDLMVIRDYLYALNS---------KRMFCYDPSHNMWLKCVSLK-RNDFQEA 518
P+ S + V+ LYA+ + CY+ + N W + R
Sbjct: 432 PMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGV 491
Query: 519 CVFNEEIYCI--CDIPVMK----VYNPVRAEWRQM 547
V N +Y + D P+++ VY+P WRQ+
Sbjct: 492 GVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQV 526
Score = 63.2 bits (152), Expect = 8e-10
Identities = 40/153 (26%), Positives = 65/153 (42%), Gaps = 18/153 (11%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y N W +A R + V + G +Y +GG D + L VECYN N+W +
Sbjct: 420 YNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYI 479
Query: 468 APLPHSFLSFDLMVIRDYLYALNS-------KRMFCYDPSHNMWLKCVSL---KRNDFQE 517
A + + V+ + LYA+ K + YDP+ N W + + +RN
Sbjct: 480 AEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRN--AG 537
Query: 518 ACVFNEEIYCI------CDIPVMKVYNPVRAEW 544
C N +Y + C++ ++ YNP +W
Sbjct: 538 VCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 570
Score = 53.9 bits (128), Expect = 5e-07
Identities = 25/67 (37%), Positives = 38/67 (56%), Gaps = 2/67 (2%)
Query: 402 RTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKR 461
R + VY P N+W+Q+AD +CR V +NG +Y++GG D L VE YN
Sbjct: 510 RKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDD--GSCNLASVEYYNPTT 567
Query: 462 NQWALVA 468
++W +V+
Sbjct: 568 DKWTVVS 574
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 131 bits (330), Expect = 2e-30
Identities = 113/497 (22%), Positives = 215/497 (43%), Gaps = 46/497 (9%)
Query: 38 EELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFK 97
EEL+ S L LK D + D T++ + PC+R +L+A PYF+
Sbjct: 9 EELR-LYQSTLLQDGLKDLLDEKKFIDCTLKA--------GDKSLPCHRLILSACSPYFR 59
Query: 98 SMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVR 157
F + E+++ V + +VD ++++ Y Y+ + L++ NV+ ++A + Q+ V
Sbjct: 60 EYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVF 119
Query: 158 EACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADL 217
C S+L +RL NC AIL+ +L A+ +++ F Q+ +EE L
Sbjct: 120 TVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQI-----CKEEDFMQL 174
Query: 218 TLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEE-DQD 276
+ +L++V+ DSL+VE E+ V ++W+ + R + +EVF C+R+ TE+ +D
Sbjct: 175 SPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKD 234
Query: 277 YLEG---LLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAEN 333
++E + + P ++K + V++ A + + + + L+ N
Sbjct: 235 HVEKDDIIKSNPDLQKK-IKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLN 293
Query: 334 PPQRLGMCAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDH 393
R GM K++++ + DP + Y LT LA + + ++ +
Sbjct: 294 DIPRHGMFVKDLILLVND--TAAVAYDPTENECY-----LTALAE-QIPRNHSSIVTQQN 345
Query: 394 DIYLAA----------QP-RTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGG 442
IY+ QP ++ + + W L R + ++ IY++ G
Sbjct: 346 QIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAG 405
Query: 443 RDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSK--------RM 494
+D T L V CY+ +W V LP +++ + +Y L K R+
Sbjct: 406 KDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRV 465
Query: 495 FCYDPSHNMWLKCVSLK 511
F ++P W +K
Sbjct: 466 FIFNPKKGDWKDLAPMK 482
Score = 40.0 bits (92), Expect = 0.007
Identities = 37/150 (24%), Positives = 58/150 (38%), Gaps = 21/150 (14%)
Query: 354 DPFLCCDPYSGDLYKVPS-PLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTD------LW 406
D LC DP + +V P+ H IS IY D ++
Sbjct: 415 DSVLCYDPVAAKWNEVKKLPIKVYGHN--------VISHKGMIYCLGGKTDDKKCTNRVF 466
Query: 407 VYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGG--RDPITGVKLKEVECYNVKRNQW 464
++ P + W+ LA + R VA G I I GG D ++ VE +++ N+W
Sbjct: 467 IFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSA----SVEAFDLTTNKW 522
Query: 465 ALVAPLPHSFLSFDLMVIRDYLYALNSKRM 494
++ P S L+ + LYA+ M
Sbjct: 523 DVMTEFPQERSSISLVSLAGSLYAIGGFAM 552
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 129 bits (324), Expect = 9e-30
Identities = 126/568 (22%), Positives = 236/568 (41%), Gaps = 69/568 (12%)
Query: 27 KPTVSAFFTGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNR 86
K + FFT HS+ +L LLCDVT+ PG G +FP +R
Sbjct: 20 KAGTTRFFTS------NTHSSVVLQGFDQLRIEGLLCDVTL---VPGDGD---EIFPVHR 67
Query: 87 NVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYA 146
++A+A YFK+MFTGGM E + +H V+ + ++D+ YT ++SL+ N++
Sbjct: 68 AMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLE 127
Query: 147 ASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHM 206
A+ LQ+ V + C FL + L NC + + A+ + ++ ++I +NF L
Sbjct: 128 AASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLST 187
Query: 207 GSIREETLADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVR 266
G + L +L VL +SL +E + A +WL R AA++ K +R
Sbjct: 188 GEFLK-----LPFERLAFVLSSNSLKHCTELELFKAACRWLR-LEDPRMDYAAKLMKNIR 241
Query: 267 WMHFTEEDQDYLEGLLTKPIVK--KYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSS 324
+ T QD + + T ++ C++++ A Y + Y V + ++ S S
Sbjct: 242 FPLMT--PQDLINYVQTVDFMRTDNTCVNLLLEA--SNYQMMPYMQPVMQSDRTAIRSDS 297
Query: 325 NSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTT 384
LV+ Q+L + +KE+ ++ ++ ++ +P+ + +
Sbjct: 298 THLVTLGGVLRQQL-VVSKELRMYDERAQE------------WRSLAPMDAPRYQHGIAV 344
Query: 385 LA---VCISPDHDIYLAAQPRTD-LWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYIL 440
+ + + + D ++ + P N W Q+A R ++ L G++Y +
Sbjct: 345 IGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAV 404
Query: 441 GGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALN-------SKR 493
GGR +L VECYN + N+W+ VA + V +Y
Sbjct: 405 GGRS--AAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNE 462
Query: 494 MFCYDPSHNMWL-------------------KCVSLKRNDFQEACVFNEEIYCICDIPVM 534
+ C+DP + W+ K + N F+ +++ + C P +
Sbjct: 463 LMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTL 522
Query: 535 KVYNPVRAEWRQMNNIPLVSETNNYRII 562
+ P+ A R +++ + N ++
Sbjct: 523 DQWTPIAAMLRGQSDVGVAVFENKIYVV 550
Score = 35.8 bits (81), Expect = 0.13
Identities = 28/131 (21%), Positives = 57/131 (43%), Gaps = 17/131 (12%)
Query: 353 RDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCI----------SPDHDIYLAAQPR 402
++ +C DP + D + +P+T + + T+ + + D+D L+ +
Sbjct: 460 QNELMCFDPDT-DKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCE-- 516
Query: 403 TDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRN 462
Y P + W +A L + + VA IY++GG ++ V+ Y+ +++
Sbjct: 517 ----YYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKD 572
Query: 463 QWALVAPLPHS 473
+W V LP S
Sbjct: 573 EWHKVFDLPES 583
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 128 bits (321), Expect = 2e-29
Identities = 124/535 (23%), Positives = 222/535 (41%), Gaps = 57/535 (10%)
Query: 36 GPEEL-KDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACP 94
GP + HS+ +L LLCDVT+ PG T FP +R ++A+A
Sbjct: 64 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTL---MPGD---TDDAFPVHRVMMASASD 117
Query: 95 YFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLE 154
YFK+MFTGGM E + +H V ++D+ YT ++SL+ N++ A+ LQ+
Sbjct: 118 YFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQIL 177
Query: 155 YVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETL 214
V + C FL + L NC + + A+ + ++ S++ +NF L G +
Sbjct: 178 PVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLK--- 234
Query: 215 ADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEED 274
L +L VL +SL +E + +WL + R AA++ K +R+ T
Sbjct: 235 --LPFERLAFVLSSNSLKHCTELELFKATCRWLR-LEEPRMDFAAKLMKNIRFPLMT--P 289
Query: 275 QDYLEGLLTKPIVK--KYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAE 332
Q+ + + T ++ C++++ A Y + Y V + ++ S + LV+
Sbjct: 290 QELINYVQTVDFMRTDNTCVNLLLEA--SNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGG 347
Query: 333 NPPQRLGMCAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLA---VCI 389
Q+L + +KE+ ++ + +K +P+ + + + +
Sbjct: 348 VLRQQL-VVSKELRMYDEKAHE------------WKSLAPMDAPRYQHGIAVIGNFLYVV 394
Query: 390 SPDHDIYLAAQPRTD-LWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITG 448
+ + D ++ + P N W Q+A R ++ L GY+Y +GGR+
Sbjct: 395 GGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRN--AA 452
Query: 449 VKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALN-------SKRMFCYDPSH 501
+L VECYN + N+W VA + V +Y K + C+DP
Sbjct: 453 GELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDT 512
Query: 502 NMWL-KCVSLKRNDFQEACVFNEEIYCI-----------CDIPVMKVYNPVRAEW 544
+ W+ K C E +Y I D+ + Y+P+ +W
Sbjct: 513 DKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQW 567
Score = 34.3 bits (77), Expect = 0.39
Identities = 18/66 (27%), Positives = 31/66 (46%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P + W +A L + + VA IY++GG ++ V+ Y+ +++W V
Sbjct: 560 YSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKV 619
Query: 468 APLPHS 473
LP S
Sbjct: 620 FDLPES 625
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 128 bits (321), Expect = 2e-29
Identities = 73/206 (35%), Positives = 109/206 (52%), Gaps = 13/206 (6%)
Query: 61 LLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
LLCD+ + V + ++ VLA+ PYF +MFT M ES+Q VT+HD+D +
Sbjct: 90 LLCDIVLHVAA--------KEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141
Query: 121 SFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
+ + LV + YT + + E NV+ L A+ +LQL VR+AC FL +LD +NC I FA
Sbjct: 142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFA 201
Query: 181 DAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVC 240
DA L A Y+ Q+F ++ + E L L Q+L ++ DSL+V SE+ V
Sbjct: 202 DAHSCSDLLKAAHRYVLQHFVDVA-----KTEEFMLLPLKQVLELVSSDSLNVPSEEEVY 256
Query: 241 HVAVQWLEAAPKERGPSAAEVFKCVR 266
+ W++ R + KCVR
Sbjct: 257 RAVLSWVKHDVDARRQHVPRLMKCVR 282
Score = 53.1 bits (126), Expect = 8e-07
Identities = 46/166 (27%), Positives = 69/166 (41%), Gaps = 19/166 (11%)
Query: 360 DPYSGDLYKVPSPLTCLAHTRTVT---TLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQ 416
DP +G V + T + R T L D +LA + Y+P N W
Sbjct: 457 DPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK-----YEPQVNVWS 511
Query: 417 QLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLS 476
+A L R VA L G +Y+ GG D + L VE Y+ K W VAP+ +
Sbjct: 512 PVASMLSRRSSAGVAVLEGALYVAGGNDGTS--CLNSVERYSPKAGAWESVAPMNIRRST 569
Query: 477 FDLMVIRDYLYALNS-------KRMFCYDPSHNMWL--KCVSLKRN 513
DL+ + +LYA+ + Y+P N W+ C+ +R+
Sbjct: 570 HDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRS 615
Score = 35.0 bits (79), Expect = 0.23
Identities = 28/110 (25%), Positives = 44/110 (40%), Gaps = 9/110 (8%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALV 467
Y P N+WQ R + VA L+G +Y GG D + L E Y+ W V
Sbjct: 409 YDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGAS--CLNSAERYDPLTGTWTSV 466
Query: 468 APLPH-------SFLSFDLMVIRDYLYALNSKRMFCYDPSHNMWLKCVSL 510
A + + L +L + Y + + + Y+P N+W S+
Sbjct: 467 AAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASM 516
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 124 bits (312), Expect = 2e-28
Identities = 126/512 (24%), Positives = 206/512 (40%), Gaps = 104/512 (20%)
Query: 36 GPEELKDTAHSAAL------LAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVL 89
G EEL+D H + ++ LCDVT+++ F +R VL
Sbjct: 5 GAEELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKI--------GDHKFSAHRIVL 56
Query: 90 AAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASD 149
AA+ PYF +MFT M E +Q + M +D + E L+++ Y G +++ + NV+ L +
Sbjct: 57 AASIPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGAS 116
Query: 150 MLQLEYVREACASFLARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSI 209
LQL+ +++AC +FL RL NC + +FA+ L A S+I Q+F ++S +
Sbjct: 117 FLQLQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVS----M 172
Query: 210 REETLADLTLAQLLAVLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMH 269
EE LA L L +L ++ D L+V+SE+ Q EAA + W+
Sbjct: 173 SEEFLA-LPLEDVLELVSRDELNVKSEE-------QVFEAA--------------LAWVR 210
Query: 270 FTEEDQD-YLEGLLTK---PIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSN 325
+ E + YL LL+ P+ + L +++ DL+
Sbjct: 211 YDREQRGPYLPELLSNIRLPLCRPQFLSD-----RVQQDDLV-----------RCCHKCR 254
Query: 326 SLVSAAEN---PPQRLGMCAKEMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTV 382
LV A++ P+R + F PR CC +G +Y V
Sbjct: 255 DLVDEAKDYHLMPER----RPHLPAFRTRPR----CCTSIAGLIYAVGG----------- 295
Query: 383 TTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGG 442
+ A + V+ P N W++ R + VA +NG +Y +GG
Sbjct: 296 ------------LNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGG 343
Query: 443 RDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNS-------KRMF 495
D ++L VE YN + + W V + + +V+ +Y +
Sbjct: 344 YD--GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVE 401
Query: 496 CYDPSHNMWLKCVSLKRN-DFQEACVFNEEIY 526
Y P + W S+ N VF IY
Sbjct: 402 TYSPETDKWTVVTSMSSNRSAAGVTVFEGRIY 433
Score = 30.8 bits (68), Expect = 4.3
Identities = 26/100 (26%), Positives = 41/100 (41%), Gaps = 13/100 (13%)
Query: 414 SWQQLADRL--LCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLP 471
+W A L CR G A L +++ GG D + + E+ Y+ +QW L+ P+
Sbjct: 456 TWHPAAGMLNKRCRHG--AASLGSKMFVCGGYDGSGFLSIAEM--YSSVADQWCLIVPMH 511
Query: 472 HSFLSFDLMVIRDYLYAL-------NSKRMFCYDPSHNMW 504
L+ LYA+ N + YDP + W
Sbjct: 512 TRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551
Score = 30.4 bits (67), Expect = 5.6
Identities = 28/125 (22%), Positives = 50/125 (40%), Gaps = 17/125 (13%)
Query: 435 GYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIRDYLYA------ 488
G IY +GG + G L VE ++ N W P+ + + V+ LYA
Sbjct: 288 GLIYAVGGLNS-AGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDG 346
Query: 489 -LNSKRMFCYDPSHNMWLKCVSL-KRNDFQEACVFNEEIYCIC-------DIPVMKVYNP 539
L + Y+P + W + S+ + V + +IY +C + ++ Y+P
Sbjct: 347 QLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIY-VCGGYDGNSSLSSVETYSP 405
Query: 540 VRAEW 544
+W
Sbjct: 406 ETDKW 410
>gi|38327518 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 124 bits (311), Expect = 3e-28
Identities = 122/526 (23%), Positives = 218/526 (41%), Gaps = 52/526 (9%)
Query: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGM 104
H +L+ L++F + + D I + + PC+R VLAA +F++MF M
Sbjct: 34 HGQKILSVLQNFREQNVFYDFKIIM--------KDEIIPCHRCVLAACSDFFRAMFEVNM 85
Query: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFL 164
E SVT+ ++ +++ + +DY YTG+ +++ NVE + S LQ+ ++ +AC+ FL
Sbjct: 86 KERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFL 145
Query: 165 ARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLA 224
+ ++L NC +L +D++G L A ++ +F L + ++ L
Sbjct: 146 IKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLL-----FKSSDFLEMNFGVLQK 200
Query: 225 VLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEED-QDYL---EG 280
L D L+V E+ V V + W + + R + + VR +EE QD L E
Sbjct: 201 CLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEES 260
Query: 281 LLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLV-SAAENPPQRLG 339
LL C D+I A++ G S P++ S++ + EN +
Sbjct: 261 LLK----STNCFDIIMDAIKCVQG-----SGGLFPDARPSTTEKYIFIHKTEENGENQYT 311
Query: 340 MCAK-EMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLA 398
C + + P+ + S Y LT + T+ + I+ + Y
Sbjct: 312 FCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIA---ESYHD 368
Query: 399 AQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGG--RDPITGVKLKEVEC 456
A +T W Y P +N + ++ R ++++GG R L +VE
Sbjct: 369 ATDQT--WCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVES 426
Query: 457 YNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSK------------RMFCYDPSHNMW 504
YN +W V+PLP + ++ +Y L S+ F Y+ + + W
Sbjct: 427 YNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQW 486
Query: 505 LKCVSLKRNDFQEACVFNEEIYC---ICDIPVMKVYN--PVRAEWR 545
+ V+ F + + C ICD+ KVY+ P W+
Sbjct: 487 SELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWK 532
Score = 33.9 bits (76), Expect = 0.50
Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 7/50 (14%)
Query: 437 IYILGGR---DPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIR 483
IYILGG D IT EV+ Y+ R++W V+P+P + F VI+
Sbjct: 553 IYILGGDYAPDEITD----EVQVYHSNRSEWEEVSPMPRALTEFYCQVIQ 598
>gi|38327516 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 124 bits (311), Expect = 3e-28
Identities = 122/526 (23%), Positives = 218/526 (41%), Gaps = 52/526 (9%)
Query: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGM 104
H +L+ L++F + + D I + + PC+R VLAA +F++MF M
Sbjct: 34 HGQKILSVLQNFREQNVFYDFKIIM--------KDEIIPCHRCVLAACSDFFRAMFEVNM 85
Query: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFL 164
E SVT+ ++ +++ + +DY YTG+ +++ NVE + S LQ+ ++ +AC+ FL
Sbjct: 86 KERDDGSVTITNLSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFL 145
Query: 165 ARRLDLTNCTAILKFADAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLA 224
+ ++L NC +L +D++G L A ++ +F L + ++ L
Sbjct: 146 IKSINLVNCLQLLSISDSYGSTSLFDHALHFVQHHFSLL-----FKSSDFLEMNFGVLQK 200
Query: 225 VLRLDSLDVESEQTVCHVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEED-QDYL---EG 280
L D L+V E+ V V + W + + R + + VR +EE QD L E
Sbjct: 201 CLESDELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETLQDCLFNEES 260
Query: 281 LLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLV-SAAENPPQRLG 339
LL C D+I A++ G S P++ S++ + EN +
Sbjct: 261 LLK----STNCFDIIMDAIKCVQG-----SGGLFPDARPSTTEKYIFIHKTEENGENQYT 311
Query: 340 MCAK-EMVIFFGHPRDPFLCCDPYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLA 398
C + + P+ + S Y LT + T+ + I+ + Y
Sbjct: 312 FCYNIKSDSWKILPQSHLIDLPGSSLSSYGEKIFLTGGCKGKCCRTVRLHIA---ESYHD 368
Query: 399 AQPRTDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGG--RDPITGVKLKEVEC 456
A +T W Y P +N + ++ R ++++GG R L +VE
Sbjct: 369 ATDQT--WCYCPVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSLLDVES 426
Query: 457 YNVKRNQWALVAPLPHSFLSFDLMVIRDYLYALNSK------------RMFCYDPSHNMW 504
YN +W V+PLP + ++ +Y L S+ F Y+ + + W
Sbjct: 427 YNPLSKEWISVSPLPRGIYYPEASTCQNVIYVLGSEVEITDAFNPSLDCFFKYNATTDQW 486
Query: 505 LKCVSLKRNDFQEACVFNEEIYC---ICDIPVMKVYN--PVRAEWR 545
+ V+ F + + C ICD+ KVY+ P W+
Sbjct: 487 SELVAEFGQFFHATLIKAVPVNCTLYICDLSTYKVYSFCPDTCVWK 532
Score = 33.9 bits (76), Expect = 0.50
Identities = 20/50 (40%), Positives = 28/50 (56%), Gaps = 7/50 (14%)
Query: 437 IYILGGR---DPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLMVIR 483
IYILGG D IT EV+ Y+ R++W V+P+P + F VI+
Sbjct: 553 IYILGGDYAPDEITD----EVQVYHSNRSEWEEVSPMPRALTEFYCQVIQ 598
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,162,965
Number of Sequences: 37866
Number of extensions: 1245096
Number of successful extensions: 4297
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 46
Number of HSP's that attempted gapping in prelim test: 3498
Number of HSP's gapped (non-prelim): 460
length of query: 674
length of database: 18,247,518
effective HSP length: 109
effective length of query: 565
effective length of database: 14,120,124
effective search space: 7977870060
effective search space used: 7977870060
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.