Guide to the Human Genome
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Search of human proteins with 45269145

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
         (624 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]       1295   0.0  
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]       1295   0.0  
gi|40807500 kelch-like 20 [Homo sapiens]                              393   e-109
gi|38194229 kelch-like 17 [Homo sapiens]                              373   e-103
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]                     368   e-102
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]                     368   e-102
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]            366   e-101
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]            366   e-101
gi|11056006 kelch-like 12 [Homo sapiens]                              365   e-101
gi|14780904 kelch-like 1 protein [Homo sapiens]                       360   3e-99
gi|55925604 kelch-like 18 [Homo sapiens]                              358   1e-98
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]              353   3e-97
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]                     352   4e-97
gi|166235129 kelch-like 3 [Homo sapiens]                              351   1e-96
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]                     342   5e-94
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]                     334   1e-91
gi|5174473 intracisternal A particle-promoted polypeptide isofor...   328   7e-90
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]            319   4e-87
gi|148664209 kelch-like 10 [Homo sapiens]                             305   8e-83
gi|223890235 intracisternal A particle-promoted polypeptide isof...   303   4e-82
gi|34101268 kelch-like 8 [Homo sapiens]                               301   1e-81
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]                    267   2e-71
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]                    261   2e-69
gi|24308181 kelch-like 9 [Homo sapiens]                               241   1e-63
gi|45643138 kelch-like 13 [Homo sapiens]                              234   2e-61
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]               233   3e-61
gi|40255071 kelch-like 23 [Homo sapiens]                              220   3e-57
gi|40018614 DRE1 protein [Homo sapiens]                               218   1e-56
gi|8922854 kelch-like 26 [Homo sapiens]                               217   2e-56
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo...   214   2e-55

>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score = 1295 bits (3351), Expect = 0.0
 Identities = 624/624 (100%), Positives = 624/624 (100%)

Query: 1   MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT 60
           MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
Sbjct: 1   MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT 60

Query: 61  KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM 120
           KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
Sbjct: 61  KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM 120

Query: 121 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
           EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
Sbjct: 121 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180

Query: 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR 240
           PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
Sbjct: 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR 240

Query: 241 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY 300
           CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
Sbjct: 241 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY 300

Query: 301 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV 360
           LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
Sbjct: 301 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV 360

Query: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
           PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
Sbjct: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420

Query: 421 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG 480
           IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
Sbjct: 421 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG 480

Query: 481 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE 540
           TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
Sbjct: 481 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE 540

Query: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600
           TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600

Query: 601 RSGVGVAVTMEPCRKQIDQQNCTC 624
           RSGVGVAVTMEPCRKQIDQQNCTC
Sbjct: 601 RSGVGVAVTMEPCRKQIDQQNCTC 624


>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score = 1295 bits (3351), Expect = 0.0
 Identities = 624/624 (100%), Positives = 624/624 (100%)

Query: 1   MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT 60
           MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
Sbjct: 1   MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT 60

Query: 61  KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM 120
           KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
Sbjct: 61  KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM 120

Query: 121 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
           EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
Sbjct: 121 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180

Query: 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR 240
           PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
Sbjct: 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR 240

Query: 241 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY 300
           CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
Sbjct: 241 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY 300

Query: 301 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV 360
           LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
Sbjct: 301 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV 360

Query: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
           PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
Sbjct: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420

Query: 421 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG 480
           IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
Sbjct: 421 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG 480

Query: 481 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE 540
           TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
Sbjct: 481 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE 540

Query: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600
           TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600

Query: 601 RSGVGVAVTMEPCRKQIDQQNCTC 624
           RSGVGVAVTMEPCRKQIDQQNCTC
Sbjct: 601 RSGVGVAVTMEPCRKQIDQQNCTC 624


>gi|40807500 kelch-like 20 [Homo sapiens]
          Length = 609

 Score =  393 bits (1010), Expect = e-109
 Identities = 226/573 (39%), Positives = 326/573 (56%), Gaps = 18/573 (3%)

Query: 54  YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
           Y  + H +Q   ++N LR  ++LCDV L V      A +  AH+V+L++ SP F+AMFT 
Sbjct: 45  YISDKHPRQTLEVINLLRKHRELCDVVLVVG-----AKKIYAHRVILSACSPYFRAMFTG 99

Query: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
            L E     V I  I  + ME LI+FAYT+ I++ E  V  ++  A + Q+  +  AC +
Sbjct: 100 ELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCE 159

Query: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
           FL +QLDPSN +GI  FA+   C EL + A ++   +F EV + EEF  L   QL+ +IS
Sbjct: 160 FLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIIS 219

Query: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
            D+LNVR E +VF+A + WVKY  ++RR  +  +L+ VR   L+P FL   +    +++S
Sbjct: 220 SDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKS 279

Query: 294 DSRCKDYLVKIFEELTLHKPTQVM------PCRAPKVGRLIYTAGGYFR-QSLSYLEAYN 346
           D  C+D + +    L L +   +M      P +  + G +++  GG+    ++S +E Y+
Sbjct: 280 DEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYD 339

Query: 347 PSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSP- 405
           P    W  +A +   R G+   V+  LLYAVGG     DG++  ++++ Y+P TNQWS  
Sbjct: 340 PQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGH----DGSSYLNSVERYDPKTNQWSSD 395

Query: 406 CAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGV 465
            AP S  R  +GV V+ G +YAVGG  G    N VERY+P+ ++W  VA M TRR+GV V
Sbjct: 396 VAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAV 455

Query: 466 AVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525
           AVL   LYAVGG DGT+ LN+ E Y P+ N W  I  M T R   G  V  + IYA GG 
Sbjct: 456 AVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR 515

Query: 526 DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYD 585
           D   +L+S ERY+  T  W+ V  M  RRS +G+ V  G++  +GG+DG T+L ++E +D
Sbjct: 516 DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFD 575

Query: 586 PDTDTWSEVTRMTSGRSGVGVAV-TMEPCRKQI 617
           PD +TW     M   R G GV V  M  C   I
Sbjct: 576 PDANTWRLYGGMNYRRLGGGVGVIKMTHCESHI 608


>gi|38194229 kelch-like 17 [Homo sapiens]
          Length = 642

 Score =  373 bits (958), Expect = e-103
 Identities = 218/557 (39%), Positives = 309/557 (55%), Gaps = 16/557 (2%)

Query: 59  HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
           H   AF  M+ +R    LCD+ L V      A +  AHKVVLAS SP F AMFTN + E 
Sbjct: 74  HYHDAFVAMSRMRQRGLLCDIVLHVA-----AKEIRAHKVVLASCSPYFHAMFTNEMSES 128

Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
               V++  I P+ +++L++FAYTA I +GE  V  ++  A + Q++ V  AC  FL+ Q
Sbjct: 129 RQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188

Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
           LDPSN +GI  FA+   C +L + A  Y+  HF +VAK EEF  L   Q++ L+S D LN
Sbjct: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248

Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
           V  E EV+ A ++WVK+D + RR +V  L++ VR   L+ +FL   +    +++    CK
Sbjct: 249 VPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCK 308

Query: 299 DYLVKIFEELTLHKPTQVM------PCRAPKVGRLIYTAGGYFRQSL-SYLEAYNPSDGT 351
           D L++  +   L +   V+      P R    G +++  GG    ++    EAY+     
Sbjct: 309 DLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDR 368

Query: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
           W  +A +   R+ +    VG  LYAVGG     DG +D + ++ Y+P+TN W P   M  
Sbjct: 369 WHVVASMSTRRARVGVAAVGNRLYAVGGY----DGTSDLATVESYDPVTNTWQPEVSMGT 424

Query: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
            R+ +GV  + G +Y+ GG  G    NS ERY+P    W  VA M TRR  V VA L+  
Sbjct: 425 RRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGN 484

Query: 472 LYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
           LYAVGG+D ++ L + E Y P+ N W  + +M + RS AGV VL   +Y AGG DG   L
Sbjct: 485 LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCL 544

Query: 532 NSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
           NSVERY  +   W  VAPM  RRS   +    G +Y +GG DG + L+S+E Y+P T+ W
Sbjct: 545 NSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW 604

Query: 592 SEVTRMTSGRSGVGVAV 608
              + M + RS VGVAV
Sbjct: 605 VAASCMFTRRSSVGVAV 621



 Score =  137 bits (345), Expect = 3e-32
 Identities = 79/190 (41%), Positives = 105/190 (55%), Gaps = 5/190 (2%)

Query: 327 LIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
           L+Y+AGGY   S L+  E Y+P  GTW  +A +   R  +    + G LYAVGG     D
Sbjct: 437 LLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGY----D 492

Query: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
            ++  + ++ Y P  N WSP A M   R+  GV V++G +Y  GG+ G    NSVERY P
Sbjct: 493 SSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSP 552

Query: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNT 505
           +   W  VAPM  RR    +  ++  LYAVGG DG++ LNS E Y P  N+W   + M T
Sbjct: 553 KAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFT 612

Query: 506 IRSGAGVCVL 515
            RS  GV VL
Sbjct: 613 RRSSVGVAVL 622



 Score = 96.3 bits (238), Expect = 8e-20
 Identities = 53/145 (36%), Positives = 77/145 (53%), Gaps = 5/145 (3%)

Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           +Y  GGY   S L+ +E Y P    W  +A +   RS     V+ G LY  GG     DG
Sbjct: 485 LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGN----DG 540

Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
            +  ++++ Y+P    W   APM++ R+   +  +DG +YAVGG+ G    NS+E+Y P 
Sbjct: 541 TSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPR 600

Query: 447 RDEWHLVAPMLTRRIGVGVAVLNRL 471
            ++W   + M TRR  VGVAVL  L
Sbjct: 601 TNKWVAASCMFTRRSSVGVAVLELL 625


>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
          Length = 709

 Score =  368 bits (945), Expect = e-102
 Identities = 207/560 (36%), Positives = 311/560 (55%), Gaps = 21/560 (3%)

Query: 58  DHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLRE 117
           +H +Q F  M      +QLCDV L    +  PA     H++VL+S S  F AMFTN +RE
Sbjct: 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPA-----HRLVLSSVSDYFAAMFTNDVRE 209

Query: 118 QGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
              E + +EG+ P  +  LI++AYT  + + E  +  +++ A + Q+  VV AC  FL++
Sbjct: 210 ARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 269

Query: 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDL 237
           QL PSN +GI +FA+  GC +LH+ A  Y   HF EV + +EF  L   ++  L++ DD+
Sbjct: 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDM 329

Query: 238 NVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRC 297
           N+  E  + +A + WV++D EQRR  +  LL  +R   L P FL   ++   + + D  C
Sbjct: 330 NIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIEC 388

Query: 298 KDYLVKI--FEELTLHKPTQVMPCRAPK---VGRLIYTAGGYFRQSLSYLEAYNPSDGTW 352
           +  +++   +  L   +P    P   P+   VG L    G    +  + +E Y+     W
Sbjct: 389 QKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMW 448

Query: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVP 412
             +A++   R      V+   LY VGGR    DG    + ++CYNP T  WS   PMS  
Sbjct: 449 TPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLNTVECYNPKTKTWSVMPPMSTH 504

Query: 413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472
           R+ +GV V++G +YAVGG  G  + N+VER++P+  +W+ VA M T R  VGVAVL+  L
Sbjct: 505 RHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKL 564

Query: 473 YAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG-QDQL 531
           YAVGG DG++ L S EC+ P  N+W +   M+  R G GV   +  +YA GG+D     L
Sbjct: 565 YAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL 624

Query: 532 NS-----VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDP 586
            S     VERYD +T+ WT VA M   R A+G+ +   ++Y +GGYDG  +L++VE YDP
Sbjct: 625 TSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDP 684

Query: 587 DTDTWSEVTRMTSGRSGVGV 606
            T+ W++V  +  GR+G  V
Sbjct: 685 QTNEWTQVAPLCLGRAGACV 704



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 5/145 (3%)

Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           +Y  GG    S L  +E ++P    W   A +   R G+      GLLYA+GG +++P  
Sbjct: 564 LYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPAS 622

Query: 387 NTDSSALDC---YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
           N  S   DC   Y+P T+ W+  A MS+ R+ +GV ++   +YAVGG  G  + N+VE Y
Sbjct: 623 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 682

Query: 444 EPERDEWHLVAPMLTRRIGVGVAVL 468
           +P+ +EW  VAP+   R G  V  +
Sbjct: 683 DPQTNEWTQVAPLCLGRAGACVVTV 707



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 42/94 (44%), Positives = 58/94 (61%)

Query: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
           ++A GG D      S+E+YD+ T  WT VA M  RR   G+ V   ++YV+GG DG   L
Sbjct: 423 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 482

Query: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
           ++VECY+P T TWS +  M++ R G+GVAV   P
Sbjct: 483 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 516


>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
          Length = 755

 Score =  368 bits (945), Expect = e-102
 Identities = 207/560 (36%), Positives = 311/560 (55%), Gaps = 21/560 (3%)

Query: 58  DHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLRE 117
           +H +Q F  M      +QLCDV L    +  PA     H++VL+S S  F AMFTN +RE
Sbjct: 201 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPA-----HRLVLSSVSDYFAAMFTNDVRE 255

Query: 118 QGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
              E + +EG+ P  +  LI++AYT  + + E  +  +++ A + Q+  VV AC  FL++
Sbjct: 256 ARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 315

Query: 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDL 237
           QL PSN +GI +FA+  GC +LH+ A  Y   HF EV + +EF  L   ++  L++ DD+
Sbjct: 316 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDM 375

Query: 238 NVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRC 297
           N+  E  + +A + WV++D EQRR  +  LL  +R   L P FL   ++   + + D  C
Sbjct: 376 NIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIEC 434

Query: 298 KDYLVKI--FEELTLHKPTQVMPCRAPK---VGRLIYTAGGYFRQSLSYLEAYNPSDGTW 352
           +  +++   +  L   +P    P   P+   VG L    G    +  + +E Y+     W
Sbjct: 435 QKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMW 494

Query: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVP 412
             +A++   R      V+   LY VGGR    DG    + ++CYNP T  WS   PMS  
Sbjct: 495 TPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLNTVECYNPKTKTWSVMPPMSTH 550

Query: 413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472
           R+ +GV V++G +YAVGG  G  + N+VER++P+  +W+ VA M T R  VGVAVL+  L
Sbjct: 551 RHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKL 610

Query: 473 YAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG-QDQL 531
           YAVGG DG++ L S EC+ P  N+W +   M+  R G GV   +  +YA GG+D     L
Sbjct: 611 YAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL 670

Query: 532 NS-----VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDP 586
            S     VERYD +T+ WT VA M   R A+G+ +   ++Y +GGYDG  +L++VE YDP
Sbjct: 671 TSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDP 730

Query: 587 DTDTWSEVTRMTSGRSGVGV 606
            T+ W++V  +  GR+G  V
Sbjct: 731 QTNEWTQVAPLCLGRAGACV 750



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 5/145 (3%)

Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           +Y  GG    S L  +E ++P    W   A +   R G+      GLLYA+GG +++P  
Sbjct: 610 LYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPAS 668

Query: 387 NTDSSALDC---YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
           N  S   DC   Y+P T+ W+  A MS+ R+ +GV ++   +YAVGG  G  + N+VE Y
Sbjct: 669 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 728

Query: 444 EPERDEWHLVAPMLTRRIGVGVAVL 468
           +P+ +EW  VAP+   R G  V  +
Sbjct: 729 DPQTNEWTQVAPLCLGRAGACVVTV 753



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 42/94 (44%), Positives = 58/94 (61%)

Query: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
           ++A GG D      S+E+YD+ T  WT VA M  RR   G+ V   ++YV+GG DG   L
Sbjct: 469 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528

Query: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
           ++VECY+P T TWS +  M++ R G+GVAV   P
Sbjct: 529 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 562


>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
          Length = 597

 Score =  366 bits (939), Expect = e-101
 Identities = 217/564 (38%), Positives = 313/564 (55%), Gaps = 19/564 (3%)

Query: 59  HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
           H K+AF +MNELR    LCDVT+      A   +  AH+VVLA+ SP F AMFT  + E 
Sbjct: 42  HMKKAFKVMNELRSQNLLCDVTIV-----AEDMEISAHRVVLAACSPYFHAMFTGEMSES 96

Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
             + V I+ +    +  LI++ YTA I + E+ V  ++  A + Q+  V + C +FL  Q
Sbjct: 97  RAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQ 156

Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
           L P N +GI  FA+   C +L  +A  Y   HF +V   EEF NL   Q+ +LIS D L 
Sbjct: 157 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLT 216

Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
           +  E +VF A I WV +D + R+ ++  L+  VR   L   +L  ++++  ++++ S CK
Sbjct: 217 ISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACK 276

Query: 299 DYLVKIF-------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
           DYL++         E+  L K  +        + +L+   GG   +++  +E Y+  +  
Sbjct: 277 DYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEER 336

Query: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
           W ++A+L   R       + GL++AVGG N    G+     +D Y+P+ +QW+  A M  
Sbjct: 337 WHQVAELPSRRCRAGMVYMAGLVFAVGGFN----GSLRVRTVDSYDPVKDQWTSVANMRD 392

Query: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
            R+ +G  V++G +YAVGG  G    +SVE Y  + +EW  VAPM TRR  VGV V+  L
Sbjct: 393 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 452

Query: 472 LYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
           LYAVGG+DG +R  L++ ECY    NEW  I  M+T RSGAGV VL+N +YA GG+DG  
Sbjct: 453 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 512

Query: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
              SVE YD  T  W  VA M   R   G+    G +YV+GG DG   L SVE Y+P TD
Sbjct: 513 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 572

Query: 590 TWSEVTR-MTSGRSGVGVAVTMEP 612
            W+ V+  M++GRS  GV V  +P
Sbjct: 573 KWTVVSSCMSTGRSYAGVTVIDKP 596


>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
          Length = 593

 Score =  366 bits (939), Expect = e-101
 Identities = 217/564 (38%), Positives = 313/564 (55%), Gaps = 19/564 (3%)

Query: 59  HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
           H K+AF +MNELR    LCDVT+      A   +  AH+VVLA+ SP F AMFT  + E 
Sbjct: 38  HMKKAFKVMNELRSQNLLCDVTIV-----AEDMEISAHRVVLAACSPYFHAMFTGEMSES 92

Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
             + V I+ +    +  LI++ YTA I + E+ V  ++  A + Q+  V + C +FL  Q
Sbjct: 93  RAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQ 152

Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
           L P N +GI  FA+   C +L  +A  Y   HF +V   EEF NL   Q+ +LIS D L 
Sbjct: 153 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLT 212

Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
           +  E +VF A I WV +D + R+ ++  L+  VR   L   +L  ++++  ++++ S CK
Sbjct: 213 ISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACK 272

Query: 299 DYLVKIF-------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
           DYL++         E+  L K  +        + +L+   GG   +++  +E Y+  +  
Sbjct: 273 DYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEER 332

Query: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
           W ++A+L   R       + GL++AVGG N    G+     +D Y+P+ +QW+  A M  
Sbjct: 333 WHQVAELPSRRCRAGMVYMAGLVFAVGGFN----GSLRVRTVDSYDPVKDQWTSVANMRD 388

Query: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
            R+ +G  V++G +YAVGG  G    +SVE Y  + +EW  VAPM TRR  VGV V+  L
Sbjct: 389 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448

Query: 472 LYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
           LYAVGG+DG +R  L++ ECY    NEW  I  M+T RSGAGV VL+N +YA GG+DG  
Sbjct: 449 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 508

Query: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
              SVE YD  T  W  VA M   R   G+    G +YV+GG DG   L SVE Y+P TD
Sbjct: 509 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 568

Query: 590 TWSEVTR-MTSGRSGVGVAVTMEP 612
            W+ V+  M++GRS  GV V  +P
Sbjct: 569 KWTVVSSCMSTGRSYAGVTVIDKP 592


>gi|11056006 kelch-like 12 [Homo sapiens]
          Length = 568

 Score =  365 bits (938), Expect = e-101
 Identities = 209/562 (37%), Positives = 306/562 (54%), Gaps = 18/562 (3%)

Query: 59  HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
           H K     MN LR S  LCDVTL+V+ +D PA     H++VLA+ S  F AMFT+ L E+
Sbjct: 15  HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPA-----HRIVLAACSDYFCAMFTSELSEK 69

Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
           G   V I+G+    ME L++F YT ++ +  + V  ++  A + Q+  V +AC +FL  Q
Sbjct: 70  GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129

Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
           LDPSN +GI +FAE   CV+L Q A  +   HF EV + EEF  LS  ++  LI  D++ 
Sbjct: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189

Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
           V  E  VF A INWVK+  ++R   +  LL+ VR   LTP ++   +     ++   +C+
Sbjct: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249

Query: 299 DYL--VKIFEELTLHKPTQVMPCRAPKVG--RLIYTAGGYFRQS--LSYLEAYNPSDGTW 352
           D +   K F      +     P    ++G   ++   GG+  Q   +  +E Y+P    W
Sbjct: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEW 309

Query: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQ---WSPCAPM 409
             L  +   R  +A   +   +Y +GG     DG +  S+++C +   ++   W   APM
Sbjct: 310 SFLPSITRKRRYVASVSLHDRIYVIGGY----DGRSRLSSVECLDYTADEDGVWYSVAPM 365

Query: 410 SVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLN 469
           +V R   G   +   IY  GG  G   H S+ERY+P  D+W ++  M T R G G+ V +
Sbjct: 366 NVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425

Query: 470 RLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
            ++Y +GG+DG N LNS E Y P    W  +T M T RSGAGV +L++ IY  GG+DG  
Sbjct: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485

Query: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
            L+SVE Y++ T++WT V  M   R  +G TV +GR+Y + GYDG++ L S+ECYDP  D
Sbjct: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545

Query: 590 TWSEVTRMTSGRSGVGVAVTME 611
           +W  VT M + R   GV V  E
Sbjct: 546 SWEVVTSMGTQRCDAGVCVLRE 567


>gi|14780904 kelch-like 1 protein [Homo sapiens]
          Length = 748

 Score =  360 bits (923), Expect = 3e-99
 Identities = 207/571 (36%), Positives = 306/571 (53%), Gaps = 23/571 (4%)

Query: 54  YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
           Y    H +Q F  M      QQLCDV L V  +  PA     H++VL+S S  F AMFT+
Sbjct: 189 YQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPA-----HRLVLSSVSDYFAAMFTS 243

Query: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
            + E   E + +EGI P  +  L++FAYT  + + E  + +++  A + Q+  VV  C  
Sbjct: 244 DVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCH 303

Query: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
           FL++ L PSN +GI  FA+  GC+EL + A  Y   +  EV + +EF  L   +L  L++
Sbjct: 304 FLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLA 363

Query: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
            DD+NV  E  +FHA + WVKYD + R   +  LL  +R   L P  L   L+   + ++
Sbjct: 364 SDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQIL-ADLENHALFKN 422

Query: 294 DSRCKDYLVKIF------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNP 347
           D  C+  +++        E  TL +  +  P R   VG L    G    +  + +E Y+ 
Sbjct: 423 DLECQKLILEAMKYHLLPERRTLMQSPRTKP-RKSTVGTLYAVGGMDNNKGATTIEKYDL 481

Query: 348 SDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCA 407
               W++   +   R      V+   L+ +GGR    DG    + ++CYNP T  W+   
Sbjct: 482 RTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGR----DGLKTLNTVECYNPKTKTWTVLP 537

Query: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
           PMS  R+ +GV V++G IYAVGG  G  + N+VER++P+  +W  VA M   R  VGVA 
Sbjct: 538 PMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAA 597

Query: 468 LNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG 527
           LN  LY+VGG DG++ L+S E Y P  N+W M   M   R G GV      +YA GG+D 
Sbjct: 598 LNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDA 657

Query: 528 QDQ------LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSV 581
                    L+ VERYD +T+TWT VAP+   R A+G+ +   R+Y +GGYDG T+L+++
Sbjct: 658 PASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTM 717

Query: 582 ECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
           E YDP T+ W+++  +  GR+G  V V  +P
Sbjct: 718 ESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748


>gi|55925604 kelch-like 18 [Homo sapiens]
          Length = 574

 Score =  358 bits (918), Expect = 1e-98
 Identities = 198/561 (35%), Positives = 297/561 (52%), Gaps = 17/561 (3%)

Query: 54  YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
           +++ +   + +G+M E+R   +LCDVTL++        +F AH++VLA+S P F AMFTN
Sbjct: 15  FSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDH-----KFSAHRIVLAASIPYFHAMFTN 69

Query: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
            + E   + + ++G+ P  +E LI FAY  ++++ ++ V  ++ GA   Q+ S+  AC  
Sbjct: 70  DMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCT 129

Query: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
           FL ++L P N +G+  FAE + C  L+  A  +I+ HF EV+  EEF  L    ++ L+S
Sbjct: 130 FLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVS 189

Query: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
           RD+LNV+ E +VF A + WV+YD EQR  Y+  LL  +R     P FL  ++Q+ ++++ 
Sbjct: 190 RDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRC 249

Query: 294 DSRCKDYL-----VKIFEELTLHKPT-QVMPCRAPKVGRLIYTAGGY--FRQSLSYLEAY 345
             +C+D +       +  E   H P  +  P     +  LIY  GG      SL+ +E +
Sbjct: 250 CHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVF 309

Query: 346 NPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSP 405
           +P    W R   +   RS +   VV GLLYA+GG     DG    S ++ YNP T+ W+ 
Sbjct: 310 DPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY----DGQLRLSTVEAYNPETDTWTR 365

Query: 406 CAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGV 465
              M+  R+ +G  V+DG IY  GG  G    +SVE Y PE D+W +V  M + R   GV
Sbjct: 366 VGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGV 425

Query: 466 AVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525
            V    +Y  GG DG    +S E Y      W     M   R   G   L + ++  GGY
Sbjct: 426 TVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY 485

Query: 526 DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYD 585
           DG   L+  E Y    + W  + PM  RRS + +    GR+Y +GGYDG + L SVE YD
Sbjct: 486 DGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYD 545

Query: 586 PDTDTWSEVTRMTSGRSGVGV 606
           P+TD W+ +  M     GVGV
Sbjct: 546 PETDCWTFMAPMACHEGGVGV 566



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 48/142 (33%), Positives = 69/142 (48%), Gaps = 5/142 (3%)

Query: 328 IYTAGGYFR-QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           IY +GG+   Q  S +E YN    TW   A +   R       +G  ++  GG     DG
Sbjct: 432 IYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY----DG 487

Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
           +   S  + Y+ + +QW    PM   R+R+ +    G +YAVGG  G  + +SVE Y+PE
Sbjct: 488 SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPE 547

Query: 447 RDEWHLVAPMLTRRIGVGVAVL 468
            D W  +APM     GVGV  +
Sbjct: 548 TDCWTFMAPMACHEGGVGVGCI 569


>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
          Length = 571

 Score =  353 bits (905), Expect = 3e-97
 Identities = 206/559 (36%), Positives = 308/559 (55%), Gaps = 18/559 (3%)

Query: 59  HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
           H++Q    +N LR   +LCD+ L+V        +  AHKVVLAS SP FKAMFT  L E+
Sbjct: 17  HSEQLLQGLNLLRQHHELCDIILRVG-----DVKIHAHKVVLASVSPYFKAMFTGNLSEK 71

Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
               V  + I    ++ ++E+AYT ++ + +  V  ++  A + QI  V++ C  FL  Q
Sbjct: 72  ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131

Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
           LDP N IGI+ FAE  GC +L+  A +YI  +F  V + EEFF L+H  L  ++S D LN
Sbjct: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191

Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
           V  E  VF+A  +W+KYD ++R+ Y+  LL +VR   L+  FL    +   +++ D  CK
Sbjct: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251

Query: 299 DYLVKIFE-----ELTLHKPTQVM--PCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
             L +  +     E  L   T +M  P  APKV   +    G F   L  +E Y P + +
Sbjct: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLF-ACLDSVEMYFPQNDS 310

Query: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGG-RNNSPDGNT---DSSALDCYNPMTNQWSPCA 407
           W+ LA L +PR     CV+   +Y +GG   N   G T     ++++C+NP TN W+   
Sbjct: 311 WIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370

Query: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
            M+  R+ +GV V+ G +YA+GG  G  +  SVE+Y P+  +W  VAPM T R     AV
Sbjct: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430

Query: 468 LNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG 527
           L+ ++YA+GG+ G   +NS E Y P ++ W M+ +M   R   GV V+   I+  GG++G
Sbjct: 431 LDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNG 489

Query: 528 QDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPD 587
              L+S+ERYD     WT   PMK  R+ +G  V    +YV+GG+ G ++L++V+ YDP 
Sbjct: 490 VSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPI 549

Query: 588 TDTWSEVTRMTSGRSGVGV 606
           +DTW +   M   R   G+
Sbjct: 550 SDTWLDSAGMIYCRCNFGL 568



 Score =  134 bits (336), Expect = 3e-31
 Identities = 80/195 (41%), Positives = 101/195 (51%), Gaps = 14/195 (7%)

Query: 427 AVGGSHG---CIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR 483
           AVGG  G   C+  +SVE Y P+ D W  +AP+   R   G+ VL++ +Y +GG     R
Sbjct: 287 AVGGKSGLFACL--DSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344

Query: 484 L--------NSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVE 535
                    NS EC+ P+ N W  +  MN  RS  GV VL   +YA GGYDGQ  L SVE
Sbjct: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404

Query: 536 RYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVT 595
           +Y  +   W  VAPM   RS     V  G IY +GGY G   ++SVE YDP  D+W  V 
Sbjct: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVA 463

Query: 596 RMTSGRSGVGVAVTM 610
            M   R   GV V +
Sbjct: 464 SMADKRIHFGVGVML 478



 Score =  122 bits (307), Expect = 8e-28
 Identities = 68/189 (35%), Positives = 101/189 (53%), Gaps = 6/189 (3%)

Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           +Y  GGY  QS L  +E Y P    W  +A +   RS  A  V+ G++YA+GG      G
Sbjct: 388 LYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-----G 442

Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
               ++++ Y+P  + W   A M+  R   GVGV+ G I+ VGG +G  H +S+ERY+P 
Sbjct: 443 PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPH 502

Query: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI 506
           +++W +  PM   R GVG AV++  LY VGG  G++ LN+ + Y P  + W     M   
Sbjct: 503 QNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYC 562

Query: 507 RSGAGVCVL 515
           R   G+  L
Sbjct: 563 RCNFGLTAL 571



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 57/148 (38%), Positives = 77/148 (52%), Gaps = 9/148 (6%)

Query: 470 RLLYAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG- 527
           ++L AVGG  G    L+S E Y+P+ + W  +  +N  R   G+CVL   +Y  GG    
Sbjct: 283 KVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATN 342

Query: 528 -------QDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDS 580
                  +   NSVE ++ +T TWT +  M   RS LG+ V  G +Y LGGYDG ++L S
Sbjct: 343 VRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQS 402

Query: 581 VECYDPDTDTWSEVTRMTSGRSGVGVAV 608
           VE Y P    W  V  MT+ RS    AV
Sbjct: 403 VEKYIPKIRKWQPVAPMTTTRSCFAAAV 430


>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
          Length = 694

 Score =  352 bits (904), Expect = 4e-97
 Identities = 194/521 (37%), Positives = 294/521 (56%), Gaps = 16/521 (3%)

Query: 97  KVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVM 156
           ++VL+S S  F AMFTN +RE   E + +EG+ P  +  LI++AYT  + + E  +  ++
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233

Query: 157 NGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAK 216
           + A + Q+  VV AC  FL++QL PSN +GI +FA+  GC +LH+ A  Y   HF EV +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293

Query: 217 QEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSL 276
            +EF  L   ++  L++ DD+N+  E  + +A + WV++D EQRR  +  LL  +R   L
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353

Query: 277 TPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK---VGRLIYTA 331
            P FL   ++   + + D  C+  +++   +  L   +P    P   P+   VG L    
Sbjct: 354 APQFL-ADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVG 412

Query: 332 GGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSS 391
           G    +  + +E Y+     W  +A++   R      V+   LY VGGR    DG    +
Sbjct: 413 GMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLN 468

Query: 392 ALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWH 451
            ++CYNP T  WS   PMS  R+ +GV V++G +YAVGG  G  + N+VER++P+  +W+
Sbjct: 469 TVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWN 528

Query: 452 LVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAG 511
            VA M T R  VGVAVL+  LYAVGG DG++ L S EC+ P  N+W +   M+  R G G
Sbjct: 529 FVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVG 588

Query: 512 VCVLHNCIYAAGGYDG-QDQLNS-----VERYDVETETWTFVAPMKHRRSALGITVHQGR 565
           V   +  +YA GG+D     L S     VERYD +T+ WT VA M   R A+G+ +   +
Sbjct: 589 VTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDK 648

Query: 566 IYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
           +Y +GGYDG  +L++VE YDP T+ W++V  +  GR+G  V
Sbjct: 649 LYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 689



 Score = 94.4 bits (233), Expect = 3e-19
 Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 5/145 (3%)

Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           +Y  GG    S L  +E ++P    W   A +   R G+      GLLYA+GG +++P  
Sbjct: 549 LYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPAS 607

Query: 387 NTDSSALDC---YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
           N  S   DC   Y+P T+ W+  A MS+ R+ +GV ++   +YAVGG  G  + N+VE Y
Sbjct: 608 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 667

Query: 444 EPERDEWHLVAPMLTRRIGVGVAVL 468
           +P+ +EW  VAP+   R G  V  +
Sbjct: 668 DPQTNEWTQVAPLCLGRAGACVVTV 692



 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 42/94 (44%), Positives = 58/94 (61%)

Query: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
           ++A GG D      S+E+YD+ T  WT VA M  RR   G+ V   ++YV+GG DG   L
Sbjct: 408 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467

Query: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
           ++VECY+P T TWS +  M++ R G+GVAV   P
Sbjct: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 501


>gi|166235129 kelch-like 3 [Homo sapiens]
          Length = 587

 Score =  351 bits (900), Expect = 1e-96
 Identities = 212/560 (37%), Positives = 312/560 (55%), Gaps = 19/560 (3%)

Query: 59  HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
           H  +AF +MNELR  Q LCDV +      A   +  AH+VVLA+ SP F AMFT  + E 
Sbjct: 32  HMGKAFKVMNELRSKQLLCDVMIV-----AEDVEIEAHRVVLAACSPYFCAMFTGDMSES 86

Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
             + + I+ +  + + +LI++ YTA I + E+ V  ++  A + Q+  V + C DFL  Q
Sbjct: 87  KAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQ 146

Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
           L P+N +GI  FA+   C +L Q+A  Y   HF EV   EEF +LS  Q+ +LIS D L 
Sbjct: 147 LHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLT 206

Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
           V  E +VF A I+W+ Y+ E R  ++  L+  VR   L  ++L   +++  ++++++ CK
Sbjct: 207 VSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCK 266

Query: 299 DYLVKI-------FEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
           D+L++         ++  L K  +  P     + +++   GG   +++  +E Y+  +  
Sbjct: 267 DFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDR 326

Query: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
           W ++A+L   R       + G +YAVGG N    G+     +D Y+ + +QW+  A M  
Sbjct: 327 WDQIAELPSRRCRAGVVFMAGHVYAVGGFN----GSLRVRTVDVYDGVKDQWTSIASMQE 382

Query: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
            R+ +G  V++  +YAVGG  G     SVE Y  + +EW  VAPM TRR  VGV V+   
Sbjct: 383 RRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGK 442

Query: 472 LYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
           LYAVGG+DG +R  L++ E Y P  NEW  +  M+T RSGAGV VL   +YA GG+DG  
Sbjct: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502

Query: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
              SVE YD  T TW  VA M   R   G+    G +YV+GG DG   L SVE Y+P TD
Sbjct: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTD 562

Query: 590 TWSEV-TRMTSGRSGVGVAV 608
            W+ + T M++GRS  GVAV
Sbjct: 563 KWTLLPTNMSTGRSYAGVAV 582



 Score =  132 bits (331), Expect = 1e-30
 Identities = 79/195 (40%), Positives = 108/195 (55%), Gaps = 4/195 (2%)

Query: 327 LIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
           L+Y  GG+   + L+ +EAY+     W  +A +   RS +   VV G LYAVGG + +  
Sbjct: 395 LLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGA-- 452

Query: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
                S ++ YNP TN+W   A MS  R+  GVGV+ G +YA GG  G +   SVE Y+P
Sbjct: 453 SRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDP 512

Query: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI-TAMN 504
             + W  VA M   R   GV  +N LLY VGG DG+  L S E Y P  ++W ++ T M+
Sbjct: 513 GTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMS 572

Query: 505 TIRSGAGVCVLHNCI 519
           T RS AGV V+H  +
Sbjct: 573 TGRSYAGVAVIHKSL 587


>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
          Length = 718

 Score =  342 bits (878), Expect = 5e-94
 Identities = 203/609 (33%), Positives = 312/609 (51%), Gaps = 29/609 (4%)

Query: 23  CPEGAGDAVMYAS-----TECKAEVTPSQHGNRTFS---YTLEDHTKQAFGIMNELRLSQ 74
           C + A D  M A      +  + +   S+  N T S   + + +H +Q    M      +
Sbjct: 120 CEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEK 179

Query: 75  QLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVME 134
           QLCDV L   +   PA     H++VL++ S  F AMFTN + E   E V +EG+ P  + 
Sbjct: 180 QLCDVLLIAGHLRIPA-----HRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234

Query: 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194
            L+++AYT  + + E  +  ++  A + Q+  V+  CS+FL++QL PSN +GI +F +  
Sbjct: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294

Query: 195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
           GC EL   A +Y   HF EV K +EF  L   ++  L+  DD+NV  E  +FHA + WV 
Sbjct: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354

Query: 255 YDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPT 314
           +D + R+  +  LL  +R   L P  L   L+   +   D  C+  L++  +   L +  
Sbjct: 355 HDVQNRQGELGMLLSYIRLPLLPPQLL-ADLETSSMFTGDLECQKLLMEAMKYHLLPERR 413

Query: 315 QVMPC-----RAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV 369
            +M       R   VG L    G    +  + +E Y+    +WL +  +   R      V
Sbjct: 414 SMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473

Query: 370 VGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVG 429
           +   LY VGGR    DG    + ++C+NP+   W+   PMS  R+ +GV  ++G +YAVG
Sbjct: 474 IDNKLYVVGGR----DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529

Query: 430 GSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAEC 489
           G  G  + N+VER++PE  +W+ VA M T R  VGV  LN  LYA+GG DG++ L S E 
Sbjct: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589

Query: 490 YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ------LNSVERYDVETET 543
           + P  N+W +   M+  R G GV   +  +Y  GG+D           + VERYD + ++
Sbjct: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649

Query: 544 WTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSG 603
           W+ VAP+   R A+ +     ++YV+GGYDGHT+L++VE YD   + W E   +  GR+G
Sbjct: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG 709

Query: 604 VGVAVTMEP 612
             V V   P
Sbjct: 710 ACVVVVKLP 718


>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
          Length = 720

 Score =  334 bits (857), Expect = 1e-91
 Identities = 197/590 (33%), Positives = 304/590 (51%), Gaps = 29/590 (4%)

Query: 23  CPEGAGDAVMYAS-----TECKAEVTPSQHGNRTFS---YTLEDHTKQAFGIMNELRLSQ 74
           C + A D  M A      +  + +   S+  N T S   + + +H +Q    M      +
Sbjct: 120 CEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEK 179

Query: 75  QLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVME 134
           QLCDV L   +   PA     H++VL++ S  F AMFTN + E   E V +EG+ P  + 
Sbjct: 180 QLCDVLLIAGHLRIPA-----HRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234

Query: 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194
            L+++AYT  + + E  +  ++  A + Q+  V+  CS+FL++QL PSN +GI +F +  
Sbjct: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294

Query: 195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
           GC EL   A +Y   HF EV K +EF  L   ++  L+  DD+NV  E  +FHA + WV 
Sbjct: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354

Query: 255 YDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPT 314
           +D + R+  +  LL  +R   L P  L   L+   +   D  C+  L++  +   L +  
Sbjct: 355 HDVQNRQGELGMLLSYIRLPLLPPQLL-ADLETSSMFTGDLECQKLLMEAMKYHLLPERR 413

Query: 315 QVMPC-----RAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV 369
            +M       R   VG L    G    +  + +E Y+    +WL +  +   R      V
Sbjct: 414 SMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473

Query: 370 VGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVG 429
           +   LY VGGR    DG    + ++C+NP+   W+   PMS  R+ +GV  ++G +YAVG
Sbjct: 474 IDNKLYVVGGR----DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529

Query: 430 GSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAEC 489
           G  G  + N+VER++PE  +W+ VA M T R  VGV  LN  LYA+GG DG++ L S E 
Sbjct: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589

Query: 490 YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ------LNSVERYDVETET 543
           + P  N+W +   M+  R G GV   +  +Y  GG+D           + VERYD + ++
Sbjct: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649

Query: 544 WTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSE 593
           W+ VAP+   R A+ +     ++YV+GGYDGHT+L++VE YD   + W E
Sbjct: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699



 Score =  153 bits (386), Expect = 5e-37
 Identities = 79/199 (39%), Positives = 111/199 (55%), Gaps = 1/199 (0%)

Query: 409 MSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVL 468
           M  PR +     + G +YAVGG        ++E+Y+   + W  +  M  RR+  GVAV+
Sbjct: 416 MQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474

Query: 469 NRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQ 528
           +  LY VGG DG   LN+ EC+ P    W ++  M+T R G GV  L   +YA GG+DG 
Sbjct: 475 DNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGW 534

Query: 529 DQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDT 588
             LN+VER+D E   W +VA M   RS +G+     ++Y +GG DG + L S+E +DP T
Sbjct: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHT 594

Query: 589 DTWSEVTRMTSGRSGVGVA 607
           + WS    M+  R GVGVA
Sbjct: 595 NKWSLCAPMSKRRGGVGVA 613



 Score = 77.0 bits (188), Expect = 5e-14
 Identities = 34/94 (36%), Positives = 54/94 (57%)

Query: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
           +YA GG D      ++E+YD+ T +W  +  M  RR   G+ V   ++YV+GG DG   L
Sbjct: 431 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTL 490

Query: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
           ++VEC++P    W+ +  M++ R G+GVA    P
Sbjct: 491 NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGP 524



 Score = 33.5 bits (75), Expect = 0.60
 Identities = 16/45 (35%), Positives = 23/45 (51%)

Query: 564 GRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
           G +Y +GG D      ++E YD  T++W  +  M   R   GVAV
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473


>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
           [Homo sapiens]
          Length = 584

 Score =  328 bits (842), Expect = 7e-90
 Identities = 200/590 (33%), Positives = 310/590 (52%), Gaps = 55/590 (9%)

Query: 54  YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
           ++ + H +     +N++R  Q  CDV LQV  +      F AH++VLA+SSP F A+FT 
Sbjct: 14  FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQES-----FKAHRLVLAASSPYFAALFTG 68

Query: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
           G++E   +VV I GI   + + L++F YT  +++G   V  ++  A M Q+  VV  C +
Sbjct: 69  GMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCE 128

Query: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
           FL  Q+DP N IGI  F+EQI C +L + +  YI++HF EV   EEF  L+  QL+ ++ 
Sbjct: 129 FLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILR 188

Query: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
            ++L++  E +VF A + W+  D  +RR +V  +L  +R   L P           +L+ 
Sbjct: 189 SEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQ---------RLLKY 239

Query: 294 DSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRL------------------IYTAGGYF 335
                D+ +++  +  L +  +V  C++PK  +                   +Y  GGY 
Sbjct: 240 IEGVSDFNLRVALQTLLKEYCEV--CKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYT 297

Query: 336 R---------QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           R         ++LS +E ++     W  ++ L   RSGL   V+GG++YA+GG  +S   
Sbjct: 298 RLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDS--- 354

Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
                  +CY+P+T QW+  A M+ PR  +GV V  G IYA+GG  G    N++ER++P+
Sbjct: 355 -MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPD 413

Query: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEWRMITAMNT 505
            ++W +V  M   R   G   +  L+Y +GG       L S E Y P    W  +  M T
Sbjct: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473

Query: 506 IRSGAGVCVLHNCIYAAGGY-DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
            R+  GV  L++CIY+ GG+ + QD L++VE+Y  E E W  VA MK  R+ + +    G
Sbjct: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533

Query: 565 RIYVLGG-YDGHTF-----LDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
            +YV GG    H F     LDSVE Y+P +DTW+E+  M + R   GVAV
Sbjct: 534 LLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAV 583



 Score =  102 bits (255), Expect = 8e-22
 Identities = 64/198 (32%), Positives = 99/198 (50%), Gaps = 15/198 (7%)

Query: 328 IYTAGGYFRQSL-SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           IY  GG+    + + +E ++P +  W  + ++ V R     C + GL+Y +GG +N    
Sbjct: 392 IYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNE--- 448

Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG---SHGCIHHNSVERY 443
             +  + + Y+P++ +WSP  PM   R  +GV  ++  IY+VGG   +   +H  +VE+Y
Sbjct: 449 GIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALH--TVEKY 506

Query: 444 EPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGG------FDGTNRLNSAECYYPERNEW 497
             E ++W  VA M   R G+ V  +N LLY  GG      F     L+S E Y P  + W
Sbjct: 507 SFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTW 566

Query: 498 RMITAMNTIRSGAGVCVL 515
             I  M T R   GV VL
Sbjct: 567 TEIGNMITSRCEGGVAVL 584



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 47/150 (31%), Positives = 68/150 (45%), Gaps = 11/150 (7%)

Query: 327 LIYTAGGYFRQSLSY--LEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSP 384
           LIY  GG   + +     E Y+P    W  L  +   R+ L    +   +Y+VGG N + 
Sbjct: 438 LIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497

Query: 385 DGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG---SHGCIHH---N 438
           D       ++ Y+    +W   A M VPR  + V  ++G +Y  GG   SH  +     +
Sbjct: 498 DA---LHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLD 554

Query: 439 SVERYEPERDEWHLVAPMLTRRIGVGVAVL 468
           SVE Y P  D W  +  M+T R   GVAVL
Sbjct: 555 SVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584


>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
          Length = 505

 Score =  319 bits (818), Expect = 4e-87
 Identities = 189/508 (37%), Positives = 279/508 (54%), Gaps = 14/508 (2%)

Query: 115 LREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
           + E   + V I+ +    +  LI++ YTA I + E+ V  ++  A + Q+  V + C +F
Sbjct: 1   MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60

Query: 175 LVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISR 234
           L  QL P N +GI  FA+   C +L  +A  Y   HF +V   EEF NL   Q+ +LIS 
Sbjct: 61  LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120

Query: 235 DDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSD 294
           D L +  E +VF A I WV +D + R+ ++  L+  VR   L   +L  ++++  ++++ 
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180

Query: 295 SRCKDYLVKIF-------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNP 347
           S CKDYL++         E+  L K  +        + +L+   GG   +++  +E Y+ 
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240

Query: 348 SDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCA 407
            +  W ++A+L   R       + GL++AVGG N    G+     +D Y+P+ +QW+  A
Sbjct: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN----GSLRVRTVDSYDPVKDQWTSVA 296

Query: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
            M   R+ +G  V++G +YAVGG  G    +SVE Y  + +EW  VAPM TRR  VGV V
Sbjct: 297 NMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGV 356

Query: 468 LNRLLYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525
           +  LLYAVGG+DG +R  L++ ECY    NEW  I  M+T RSGAGV VL+N +YA GG+
Sbjct: 357 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 416

Query: 526 DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYD 585
           DG     SVE YD  T  W  VA M   R   G+    G +YV+GG DG   L SVE Y+
Sbjct: 417 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476

Query: 586 PDTDTWSEVTR-MTSGRSGVGVAVTMEP 612
           P TD W+ V+  M++GRS  GV V  +P
Sbjct: 477 PTTDKWTVVSSCMSTGRSYAGVTVIDKP 504


>gi|148664209 kelch-like 10 [Homo sapiens]
          Length = 608

 Score =  305 bits (781), Expect = 8e-83
 Identities = 181/553 (32%), Positives = 288/553 (52%), Gaps = 19/553 (3%)

Query: 66  IMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI 125
           I NELRL  +LCDV ++V        +F AHK +L S S  F+A+FT+G      +V +I
Sbjct: 28  IFNELRLEGKLCDVVIKVN-----GFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNI 82

Query: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
            GI P +M+ +IE+AYT ++ +    V  ++  A  + I  +VR C +FL  +L   N I
Sbjct: 83  PGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCI 142

Query: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAK-QEEFFNLSHCQLVTLISRDDLNVRCESE 244
           GI  F +   C EL Q+A  +I  +F E+ K   EF  LS  +L  +I +D+LNV+ E  
Sbjct: 143 GICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDA 202

Query: 245 VFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLV-- 302
           VF A + W+ +D + R+ ++  LL  VR   +   +    ++  + ++    CK  ++  
Sbjct: 203 VFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINA 262

Query: 303 -KIFEELTLHKPTQ---VMPCRAPKVG-RLIYTAGGYFRQS-LSYLEAYNPSDGTWLRLA 356
            K   +L ++ P+      P   P++   +++  GG+   S  + +EAY+     W+ + 
Sbjct: 263 LKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVT 322

Query: 357 -DLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNR 415
            + + PR+      + G +Y +GG ++    N+    +  ++P+   W   APM   R  
Sbjct: 323 CEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNS----VKRFDPVKKTWHQVAPMHSRRCY 378

Query: 416 IGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV 475
           + V V+   IYA+GG  G +  N+ ERYEPE ++W L+APM  +R       L   +Y  
Sbjct: 379 VSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC 438

Query: 476 GGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVE 535
           GGF+G   L +AE Y  E N+W +I  M + RSG GV      +YA GG+DG ++L S E
Sbjct: 439 GGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAE 498

Query: 536 RYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVT 595
            Y     TW  +  M + RS  GI V    ++V+GG++G T   +VECYD  TD W +  
Sbjct: 499 AYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAH 558

Query: 596 RMTSGRSGVGVAV 608
            M+  RS +   V
Sbjct: 559 DMSIYRSALSCCV 571



 Score = 30.8 bits (68), Expect = 3.9
 Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 1/51 (1%)

Query: 324 VGRLIYTAGGYFRQSLSY-LEAYNPSDGTWLRLADLQVPRSGLAGCVVGGL 373
           V  L++  GG+   + ++ +E Y+     W    D+ + RS L+ CVV GL
Sbjct: 525 VDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGL 575


>gi|223890235 intracisternal A particle-promoted polypeptide isoform
           2 [Homo sapiens]
          Length = 582

 Score =  303 bits (775), Expect = 4e-82
 Identities = 190/574 (33%), Positives = 297/574 (51%), Gaps = 57/574 (9%)

Query: 54  YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
           ++ + H +     +N++R  Q  CDV LQV  +      F AH++VLA+SSP F A+FT 
Sbjct: 14  FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQES-----FKAHRLVLAASSPYFAALFTG 68

Query: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
           G++E   +VV I GI   + + L++F YT  +++G   V  ++  A M Q+  VV  C +
Sbjct: 69  GMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCE 128

Query: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
           FL  Q+DP N IGI  F+EQI C +L + +  YI++HF EV   EEF  L+  QL+ ++ 
Sbjct: 129 FLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILR 188

Query: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
            ++L++  E +VF A + W+  D  +RR +V  +L  +R   L P           +L+ 
Sbjct: 189 SEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQ---------RLLKY 239

Query: 294 DSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRL------------------IYTAGGYF 335
                D+ +++  +  L +  +V  C++PK  +                   +Y  GGY 
Sbjct: 240 IEGVSDFNLRVALQTLLKEYCEV--CKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYT 297

Query: 336 R---------QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           R         ++LS +E ++     W  ++ L   RSGL   V+GG++YA+GG  +S   
Sbjct: 298 RLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDS--- 354

Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
                  +CY+P+T QW+  A M+ PR  +GV V  G IYA+GG  G    N++ER++P+
Sbjct: 355 -MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPD 413

Query: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEWRMITAMNT 505
            ++W +V  M   R   G   +  L+Y +GG       L S E Y P    W  +  M T
Sbjct: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473

Query: 506 IRSGAGVCVLHNCIYAAGGY-DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
            R+  GV  L++CIY+ GG+ + QD L++VE+Y  E E W  VA MK  R+ + +    G
Sbjct: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533

Query: 565 RIYVLGG-YDGHTFLDSVECYDPDTDTWSEVTRM 597
            +YV GG    H FL       PDT  + EV R+
Sbjct: 534 LLYVSGGRSSSHDFL------APDTHRY-EVFRL 560



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 49/140 (35%), Positives = 69/140 (49%), Gaps = 8/140 (5%)

Query: 470 RLLYAVGGF--------DGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYA 521
           + LYAVGG+          +  L+  E +      W  +++++  RSG GV VL   +YA
Sbjct: 288 KYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYA 347

Query: 522 AGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSV 581
            GG       +  E YD  T+ WT VA M H R  LG+ V  G IY LGG+ G    +++
Sbjct: 348 IGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTI 407

Query: 582 ECYDPDTDTWSEVTRMTSGR 601
           E +DPD + W  V  M   R
Sbjct: 408 ERFDPDENKWEVVGNMAVSR 427



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 38/98 (38%), Positives = 50/98 (51%), Gaps = 8/98 (8%)

Query: 519 IYAAGGY--------DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLG 570
           +YA GGY             L+ VER+D  ++ WT V+ +   RS LG+TV  G +Y +G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349

Query: 571 GYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
           G       D  ECYDP T  W+ V  M   R G+GV V
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387


>gi|34101268 kelch-like 8 [Homo sapiens]
          Length = 620

 Score =  301 bits (771), Expect = 1e-81
 Identities = 182/571 (31%), Positives = 291/571 (50%), Gaps = 20/571 (3%)

Query: 48  GNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVF 107
           G  +F +   +  K   G +     + +LCDVTL+V      +     HK+VLA   P F
Sbjct: 38  GEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVG-----SKLISCHKLVLACVIPYF 92

Query: 108 KAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSV 167
           +AMF + + E    ++ I       +E L++F Y++ +++    V  ++  A + Q++ V
Sbjct: 93  RAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELV 152

Query: 168 VRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQ 227
            RAC +++     PSN + +  FAE    ++L   A +Y   HF EV + E+F ++S   
Sbjct: 153 ARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQH 212

Query: 228 LVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQK 287
           L  L+S  DLN+  E +V++A I W+  + +    ++   L  VR   L  +FL   + K
Sbjct: 213 LHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAK 272

Query: 288 CEILQSDSRCKDYLVKIFEELTLHKPTQVMPC---------RAPKVGRLIYTAG-GYFRQ 337
            +I++ + +C+D L +      LH  ++ +P          R    G L    G G    
Sbjct: 273 EQIVKQNLKCRDLLDEA-RNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGD 331

Query: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
               +E Y+ +  +W    ++   R  +    V G +YAVGG     DGN    +++ ++
Sbjct: 332 PFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGH----DGNEHLGSMEMFD 387

Query: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
           P+TN+W   A M+  R  I +  + G IYA+GG       N VERY+ E D+W  VAPM 
Sbjct: 388 PLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMN 447

Query: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517
           T R GVG   L   +YAVGG DG   L+S E Y P  ++W  +  M   R+G GV  LH 
Sbjct: 448 TPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHG 507

Query: 518 CIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF 577
           C+Y  GG+D    L+SVERYD  +  W +VA +   R  +GI    G+I+ +GG++G+ +
Sbjct: 508 CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAY 567

Query: 578 LDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
           L++VE +DP  + W  V  ++  R+G GVAV
Sbjct: 568 LNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 50/145 (34%), Positives = 80/145 (55%), Gaps = 5/145 (3%)

Query: 328 IYTAGGYFRQ-SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           +Y  GG     SLS +E Y+P    W+ + ++   R+G     + G LY VGG     D 
Sbjct: 462 VYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGF----DD 517

Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
           N+  S+++ Y+P +N+W   A ++ PR  +G+  + G I+AVGG +G  + N+VE ++P 
Sbjct: 518 NSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPV 577

Query: 447 RDEWHLVAPMLTRRIGVGVAVLNRL 471
            + W LV  +   R G GVAV + L
Sbjct: 578 LNRWELVGSVSHCRAGAGVAVCSCL 602


>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
          Length = 586

 Score =  267 bits (683), Expect = 2e-71
 Identities = 173/540 (32%), Positives = 268/540 (49%), Gaps = 29/540 (5%)

Query: 65  GIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVS 124
           G+MN +R  + LCDV L V+ +  PA     H+VVLA++S  F  MFT  + E     V 
Sbjct: 32  GVMNNMRKQKTLCDVILMVQERKIPA-----HRVVLAAASHFFNLMFTTNMLESKSFEVE 86

Query: 125 IEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184
           ++   P ++E+L+EFAYTA IS+    V  +++ A  YQI+ V + C DFL +Q+D SN 
Sbjct: 87  LKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNC 146

Query: 185 IGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESE 244
           +GI+  AE + C EL   A ++I+ HF EV K +EF  L   ++  L+++D L VR E +
Sbjct: 147 LGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 206

Query: 245 VFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVK- 303
           V+ A + W+KYD   R+ ++  +L  VR   ++ NFL   +Q   ++Q +  C   ++  
Sbjct: 207 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISG 266

Query: 304 -IFEELTLHKPTQVMPCRAPKVGRLIYTA---GGYFRQSLSYLEAYNPSDGTWLRLADLQ 359
             +  L+     +++    P+  +  Y     GG   QS  Y   +NP D +W    D++
Sbjct: 267 MRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRY---FNPKDYSW---TDIR 320

Query: 360 VP--RSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI 416
            P  +   A CV    ++Y +GG    P        +DCYN + + W        PR+ +
Sbjct: 321 CPFEKRRDAACVFWDNVVYILGGSQLFP-----IKRMDCYNVVKDSWYSKLGPPTPRDSL 375

Query: 417 GVGVIDGHIYAVGGSH-GCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV 475
                +G IY  GGS  G       E Y+   + WH    MLT+R   G+   N L+Y  
Sbjct: 376 AACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVC 435

Query: 476 GGFDGTN----RLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
           GG  G N     LNS E Y P    W  +  M   R   G+  + + I+A GG +G   L
Sbjct: 436 GGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGL 495

Query: 532 NSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
           ++VE YD++   W  V+PM  +   +        +YVL G+ G   L  +  Y+ +TD W
Sbjct: 496 DNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 61/217 (28%), Positives = 89/217 (41%), Gaps = 6/217 (2%)

Query: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
           G +   +   +NP    W+        R        D  +Y +GGS        ++ Y  
Sbjct: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMDCYNV 357

Query: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFD-GTNRLNSAECYYPERNEWRMITAMN 504
            +D W+      T R  +        +Y  GG + G + L   ECY      W    +M 
Sbjct: 358 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSML 417

Query: 505 TIRSGAGVCVLHNCIYAAGGYDGQDQ----LNSVERYDVETETWTFVAPMKHRRSALGIT 560
           T R   G+   +  IY  GG  G +     LNS E YD  TETWT + PM   R   G+ 
Sbjct: 418 TQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLV 477

Query: 561 VHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRM 597
             + +I+ +GG +G   LD+VE YD   + W  V+ M
Sbjct: 478 FVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 514



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 10/190 (5%)

Query: 422 DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGT 481
           D  I   GGS       S   + P+   W  +     +R        + ++Y +GG    
Sbjct: 292 DYRIALFGGSQP----QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-L 346

Query: 482 NRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD-GQDQLNSVERYDVE 540
             +   +CY   ++ W       T R     C     IY +GG + G   L   E YD  
Sbjct: 347 FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTR 406

Query: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF----LDSVECYDPDTDTWSEVTR 596
           TE+W     M  +R + G+    G IYV GG  G+      L+S E YDP T+TW+E+  
Sbjct: 407 TESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 466

Query: 597 MTSGRSGVGV 606
           M   R   G+
Sbjct: 467 MIEARKNHGL 476


>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
          Length = 564

 Score =  261 bits (666), Expect = 2e-69
 Identities = 170/539 (31%), Positives = 266/539 (49%), Gaps = 29/539 (5%)

Query: 66  IMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI 125
           + + + L + LCDV L V+ +  PA     H+VVLA++S  F  MFT  + E     V +
Sbjct: 11  LTSHINLKKTLCDVILMVQERKIPA-----HRVVLAAASHFFNLMFTTNMLESKSFEVEL 65

Query: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
           +   P ++E+L+EFAYTA IS+    V  +++ A  YQI+ V + C DFL +Q+D SN +
Sbjct: 66  KDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCL 125

Query: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
           GI+  AE + C EL   A ++I+ HF EV K +EF  L   ++  L+++D L VR E +V
Sbjct: 126 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 185

Query: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVK-- 303
           + A + W+KYD   R+ ++  +L  VR   ++ NFL   +Q   ++Q +  C   ++   
Sbjct: 186 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGM 245

Query: 304 IFEELTLHKPTQVMPCRAPKVGRLIYTA---GGYFRQSLSYLEAYNPSDGTWLRLADLQV 360
            +  L+     +++    P+  +  Y     GG   QS  Y   +NP D +W    D++ 
Sbjct: 246 RYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRY---FNPKDYSW---TDIRC 299

Query: 361 P--RSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIG 417
           P  +   A CV    ++Y +GG    P        +DCYN + + W        PR+ + 
Sbjct: 300 PFEKRRDAACVFWDNVVYILGGSQLFP-----IKRMDCYNVVKDSWYSKLGPPTPRDSLA 354

Query: 418 VGVIDGHIYAVGGSH-GCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVG 476
               +G IY  GGS  G       E Y+   + WH    MLT+R   G+   N L+Y  G
Sbjct: 355 ACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCG 414

Query: 477 GFDGTN----RLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLN 532
           G  G N     LNS E Y P    W  +  M   R   G+  + + I+A GG +G   L+
Sbjct: 415 GSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLD 474

Query: 533 SVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
           +VE YD++   W  V+PM  +   +        +YVL G+ G   L  +  Y+ +TD W
Sbjct: 475 NVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 61/217 (28%), Positives = 89/217 (41%), Gaps = 6/217 (2%)

Query: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
           G +   +   +NP    W+        R        D  +Y +GGS        ++ Y  
Sbjct: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMDCYNV 335

Query: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFD-GTNRLNSAECYYPERNEWRMITAMN 504
            +D W+      T R  +        +Y  GG + G + L   ECY      W    +M 
Sbjct: 336 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSML 395

Query: 505 TIRSGAGVCVLHNCIYAAGGYDGQDQ----LNSVERYDVETETWTFVAPMKHRRSALGIT 560
           T R   G+   +  IY  GG  G +     LNS E YD  TETWT + PM   R   G+ 
Sbjct: 396 TQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLV 455

Query: 561 VHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRM 597
             + +I+ +GG +G   LD+VE YD   + W  V+ M
Sbjct: 456 FVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 492



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 10/190 (5%)

Query: 422 DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGT 481
           D  I   GGS       S   + P+   W  +     +R        + ++Y +GG    
Sbjct: 270 DYRIALFGGSQP----QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-L 324

Query: 482 NRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD-GQDQLNSVERYDVE 540
             +   +CY   ++ W       T R     C     IY +GG + G   L   E YD  
Sbjct: 325 FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTR 384

Query: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF----LDSVECYDPDTDTWSEVTR 596
           TE+W     M  +R + G+    G IYV GG  G+      L+S E YDP T+TW+E+  
Sbjct: 385 TESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 444

Query: 597 MTSGRSGVGV 606
           M   R   G+
Sbjct: 445 MIEARKNHGL 454


>gi|24308181 kelch-like 9 [Homo sapiens]
          Length = 617

 Score =  241 bits (616), Expect = 1e-63
 Identities = 158/579 (27%), Positives = 264/579 (45%), Gaps = 19/579 (3%)

Query: 40  AEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVV 99
           A + P + G   F +T   H+       ++LR+   LCDVTL     D     F  H+ +
Sbjct: 14  AHLQPCKAGTTRF-FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEI---FPVHRAM 69

Query: 100 LASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGA 159
           +AS+S  FKAMFT G++EQ +  + + G++   ++++I+F YTA +S+    +   +  A
Sbjct: 70  MASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAA 129

Query: 160 VMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEE 219
              QI  V+  C  FL+  +   N + +   A     +E+ +    +I  +F  +    E
Sbjct: 130 SFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGE 189

Query: 220 FFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPN 279
           F  L   +L  ++S + L    E E+F A   W++ + + R  Y   L++ +R   +TP 
Sbjct: 190 FLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQ 248

Query: 280 FLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKV---GRLIYTAGGYFR 336
            L   +Q  + +++D+ C + L++      +     VM      +      + T GG  R
Sbjct: 249 DLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLR 308

Query: 337 QSL---SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN-SPDGNTDSSA 392
           Q L     L  Y+     W  LA +  PR      V+G  LY VGG++N    G T    
Sbjct: 309 QQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDT 368

Query: 393 LDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHL 452
           +  ++P  N+W   A ++  R    +  + GH+YAVGG        +VE Y P  +EW  
Sbjct: 369 VFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSY 428

Query: 453 VAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGV 512
           VA M     G    V   L+Y  GG       N   C+ P+ ++W     M T+R    +
Sbjct: 429 VAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCM 488

Query: 513 CVLHNCIYAAG-----GYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIY 567
           C + + +Y  G     G    D + S E Y    + WT +A M   +S +G+ V + +IY
Sbjct: 489 CTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIY 548

Query: 568 VLGGY--DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGV 604
           V+GGY  +    ++ V+ YDP+ D W +V  +     G+
Sbjct: 549 VVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGI 587



 Score =  104 bits (259), Expect = 3e-22
 Identities = 64/198 (32%), Positives = 95/198 (47%), Gaps = 11/198 (5%)

Query: 325 GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSP 384
           G L    G      L+ +E YNP    W  +A +  P  G AG V GGL+Y  GG  +  
Sbjct: 399 GHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITH-- 456

Query: 385 DGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSV-- 440
             +T  + L C++P T++W   APM+  R    +  +   +Y +GG+H  G   ++ V  
Sbjct: 457 --DTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS 514

Query: 441 -ERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEW 497
            E Y P  D+W  +A ML  +  VGVAV    +Y VGG+   NR  +   + Y PE++EW
Sbjct: 515 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW 574

Query: 498 RMITAMNTIRSGAGVCVL 515
             +  +     G   C L
Sbjct: 575 HKVFDLPESLGGIRACTL 592


>gi|45643138 kelch-like 13 [Homo sapiens]
          Length = 655

 Score =  234 bits (596), Expect = 2e-61
 Identities = 155/574 (27%), Positives = 260/574 (45%), Gaps = 18/574 (3%)

Query: 45  SQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSS 104
           S     T  +T   H+       ++LRL   LCDVTL     D     F  H+V++AS+S
Sbjct: 60  SSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDA---FPVHRVMMASAS 116

Query: 105 PVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQI 164
             FKAMFT G++EQ +  + + G+    + ++I+F YTA +S+    +   +  A   QI
Sbjct: 117 DYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQI 176

Query: 165 DSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLS 224
             V+  C  FL+  +   N + +   A      E+ +    ++  +F  +    EF  L 
Sbjct: 177 LPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLP 236

Query: 225 HCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQ 284
             +L  ++S + L    E E+F A   W++ + E R  +   L++ +R   +TP  L   
Sbjct: 237 FERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINY 295

Query: 285 LQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPKVGRL-IYTAGGYFRQSL-- 339
           +Q  + +++D+ C + L++   ++ +   +P       A +     + T GG  RQ L  
Sbjct: 296 VQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVV 355

Query: 340 -SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN-SPDGNTDSSALDCYN 397
              L  Y+     W  LA +  PR      V+G  LY VGG++N    G T    +  ++
Sbjct: 356 SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415

Query: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
           P  N+W   A ++  R    +  + G++YAVGG +      +VE Y P  +EW  VA M 
Sbjct: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMS 475

Query: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517
               G    V   ++Y  GG           C+ P+ ++W     M T+R    +C +  
Sbjct: 476 EPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGE 535

Query: 518 CIYAAG-----GYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGY 572
            +Y  G     G    D + S E Y    + WT +A M   +S +G+ V + +IYV+GGY
Sbjct: 536 RLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY 595

Query: 573 --DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGV 604
             +    ++ V+ YDPD D W +V  +     G+
Sbjct: 596 SWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGI 629



 Score =  100 bits (248), Expect = 5e-21
 Identities = 62/196 (31%), Positives = 94/196 (47%), Gaps = 12/196 (6%)

Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
           +Y  GG      L  +E YNP    W  +A +  P  G AG V GG++Y  GG  +    
Sbjct: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITH---- 498

Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSV---E 441
           +T    L C++P T++W   APM+  R    +  +   +Y +GG+H  G   ++ V   E
Sbjct: 499 DTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCE 558

Query: 442 RYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEWRM 499
            Y P  D+W  +A ML  +  VGVAV    +Y VGG+   NR  +   + Y P+++EW  
Sbjct: 559 YYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHK 618

Query: 500 ITAMNTIRSGAGVCVL 515
           +  +     G   C L
Sbjct: 619 VFDLPESLGGIRACTL 634


>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
          Length = 589

 Score =  233 bits (595), Expect = 3e-61
 Identities = 162/545 (29%), Positives = 259/545 (47%), Gaps = 27/545 (4%)

Query: 67  MNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIE 126
           +N LR      DVTL      A    F  H+ VLA+SS  F+AMF++GLRE   + V+ +
Sbjct: 36  LNTLRKHCMFTDVTLW-----AGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQ 90

Query: 127 -GIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
             +HP+V+E L++FAY++ I++ E+    ++    M Q   V  A ++FL + L PSN +
Sbjct: 91  DNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCL 150

Query: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
           G+   ++   C  L++ +     +HF  V + E+F +LS   L+ LIS D+L    E  V
Sbjct: 151 GMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVV 210

Query: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK---DYLV 302
           F A + WVK+D E R+ ++  LLR+VR   L  + LQ  +    +L +D R K   D  +
Sbjct: 211 FEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEAL 270

Query: 303 KIFEELTLHKPTQVMPCRAP-KVGRLIYTAGGY-FRQSLSYLEAYNPSDGTWLRLADLQV 360
           +    +  +      PC  P K G  +   GG  F     Y   +   +   +  ADL  
Sbjct: 271 RCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKE--IIPKADLPS 328

Query: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
           PR   +   +G  +Y  GGR +    N  S  +  Y+ +  +WS  APM + R   G   
Sbjct: 329 PRKEFSASAIGCKVYVTGGRGSE---NGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAE 385

Query: 421 IDGHIYAVGG---------SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
           ++  +Y VGG         +   +    VE+Y+P  ++W +VAP+        V      
Sbjct: 386 LENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLK 445

Query: 472 LYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ 530
           L+  GG     + ++  +CY P  N W +              VL + I+  GG D +  
Sbjct: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504

Query: 531 LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDT 590
             S  R+D ET  WT +  M  +R +        ++YV+GGY G     +++CYDP +DT
Sbjct: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564

Query: 591 WSEVT 595
           W+ +T
Sbjct: 565 WNCIT 569



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 46/166 (27%), Positives = 72/166 (43%), Gaps = 4/166 (2%)

Query: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
           SL  +E Y+P    W+ +A L+   S  A       L+  GG +   D     S + CY+
Sbjct: 410 SLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDM---VSKVQCYD 466

Query: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
           P  N+W+  A    P       V+   I+ +GG        S  R++ E ++W  +  M 
Sbjct: 467 PSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTE-FTAASAYRFDCETNQWTRIGDMT 525

Query: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAM 503
            +R+          LY VGG+ GT R  + +CY P  + W  IT +
Sbjct: 526 AKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTV 571



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 10/98 (10%)

Query: 519 IYAAGGYDGQDQLNS-VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDG--- 574
           +Y  GG   ++ ++  V  YD   E W+  APM   R   G    +  +YV+GG+     
Sbjct: 342 VYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAG 401

Query: 575 ------HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
                    L  VE YDP  + W  V  +  G S   V
Sbjct: 402 VFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439


>gi|40255071 kelch-like 23 [Homo sapiens]
          Length = 558

 Score =  220 bits (561), Expect = 3e-57
 Identities = 165/574 (28%), Positives = 259/574 (45%), Gaps = 43/574 (7%)

Query: 48  GNRTFSYTLED--HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSP 105
           G   + Y  +D  H            L     D+TLQ          F  H+ VLA+ S 
Sbjct: 5   GQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCP----SGIIFHCHRAVLAACSN 60

Query: 106 VFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQID 165
            FKAMFT  ++E+    + + GIH  ++E L+ +AYT+ I + ++ V  ++  A + Q  
Sbjct: 61  YFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFL 120

Query: 166 SVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSH 225
           SV +AC  FLV+ LD  N IG+ +FAE   C EL + +R  +   F EV +QEEF  +S 
Sbjct: 121 SVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISL 180

Query: 226 CQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQL 285
            + + ++SR +L+V  E  +    I W  +D E R   +  LL  +    + P +L+  L
Sbjct: 181 EKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINI-DIDPVYLKTAL 239

Query: 286 ---QKCEILQSDSRCKDY--LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLS 340
              + C + ++  R   Y  L  + +E++  + T  M           Y  GGY+   LS
Sbjct: 240 GLQRSCLLTENKIRSLIYNALNPMHKEIS-QRSTATM-----------YIIGGYYWHPLS 287

Query: 341 YLEAYNPSDGTWLRLADL-QVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALD---CY 396
            +  ++P    W++ A++    R       +G  +Y  GG         +  ALD    Y
Sbjct: 288 EVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTD-----NIEALDTVWIY 342

Query: 397 NPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM 456
           N  +++W+   PM   R       + G +YA+GG          E Y+P +++W  +A M
Sbjct: 343 NSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANM 402

Query: 457 LTRRIGVGVAVLNRLLYAVG---GFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVC 513
           +         VL+ ++Y +G   G+ G+   +  + Y  + NEW +IT+      G    
Sbjct: 403 IKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSV 462

Query: 514 VLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG-- 571
              N +Y  GG     Q    E YD E   W  +APM  RR   G  +  G IYV GG  
Sbjct: 463 PFENKLYLVGG-----QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYS 517

Query: 572 YDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVG 605
           Y   T+L S+E YDPD + W  V  + S     G
Sbjct: 518 YSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHG 551



 Score = 87.0 bits (214), Expect = 5e-17
 Identities = 55/198 (27%), Positives = 92/198 (46%), Gaps = 10/198 (5%)

Query: 321 APKVGRLIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGG 379
           A  +G  +Y  GGY + +     E Y+P    W+ +A++         CV+  ++Y +GG
Sbjct: 364 AVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGG 423

Query: 380 RNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNS 439
                 G+     +  YN   N+WS       P   +     +  +Y VGG         
Sbjct: 424 HCGYR-GSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQT-----TI 477

Query: 440 VERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEW 497
            E Y+PE++EW  +APM+ RR+  G  ++N  +Y  GG+  +    L S E Y P+ N+W
Sbjct: 478 TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW 537

Query: 498 RMITAM-NTIRSGAGVCV 514
            ++  + + +RS   VCV
Sbjct: 538 EIVGNLPSAMRSHGCVCV 555


>gi|40018614 DRE1 protein [Homo sapiens]
          Length = 600

 Score =  218 bits (556), Expect = 1e-56
 Identities = 163/560 (29%), Positives = 255/560 (45%), Gaps = 27/560 (4%)

Query: 48  GNRTFSYTL-EDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPV 106
           G+  F ++    H +    I NE R S+   DV + V+ ++ P      H+ VL++ S  
Sbjct: 36  GHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPC-----HRAVLSACSSY 90

Query: 107 FKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDS 166
           F+AMF N  RE    +V I GI  + ME  +++ YT  + +  + V ++   + ++QI  
Sbjct: 91  FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISV 150

Query: 167 VVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHC 226
           +  AC+ FL +QLDP N +GI  FA+      L  + + +    F +V++ EEF  L   
Sbjct: 151 LRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKD 210

Query: 227 QLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQ 286
           +L+  I  D+L +  E  VF A + WV    + RR  +  LL  VR   L PN+    ++
Sbjct: 211 ELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE 270

Query: 287 KCEILQSDSRCKDYLVKIFEELTLHK---PTQVMPCRAPKVGRLIYTAGGYFRQ---SLS 340
             +++Q+   C   L +      L       +  P R+     +I   GG  R    +L 
Sbjct: 271 VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLP 330

Query: 341 YLEAYNPSDGTWLRLADL-QVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPM 399
           Y E Y+P  G W  LA L +  +S  A C +   +   GGR NS D       +  YN  
Sbjct: 331 YTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRD-------VWIYNSQ 383

Query: 400 TNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTR 459
            N W   A ++  R R  + V+ G +Y VGG  G    +SVE Y+   + W  VAP+   
Sbjct: 384 LNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEA 443

Query: 460 RIGVGV-AVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNC 518
                V + + +L    GG D     +  + Y PE N W +  A+   +       L+N 
Sbjct: 444 VSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNL 503

Query: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG-YDGHTF 577
           IY AGG        ++  YD   + W  V     R+   G++V  G+IY+LGG  +    
Sbjct: 504 IYVAGGL-----TKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEA 558

Query: 578 LDSVECYDPDTDTWSEVTRM 597
            D++ CYDP T   + V  M
Sbjct: 559 TDTILCYDPATSIITGVAAM 578



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 48/135 (35%), Positives = 67/135 (49%), Gaps = 12/135 (8%)

Query: 475 VGGFDGTNRLNSAECYYPERNEWRMITAMNTI-RSGAGVCVLHNCIYAAGGYDGQDQLNS 533
           VGGF+    L   ECY P   EW+ +  +    +S   VC L N I  +GG     ++NS
Sbjct: 324 VGGFN----LPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG-----RINS 374

Query: 534 --VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
             V  Y+ +   W  VA +   R    + V  G++YV+GGYDG   L SVECYD  ++ W
Sbjct: 375 RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRW 434

Query: 592 SEVTRMTSGRSGVGV 606
           +EV  +    S   V
Sbjct: 435 TEVAPLKEAVSSPAV 449


>gi|8922854 kelch-like 26 [Homo sapiens]
          Length = 615

 Score =  217 bits (553), Expect = 2e-56
 Identities = 159/590 (26%), Positives = 263/590 (44%), Gaps = 29/590 (4%)

Query: 43  TPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLAS 102
           T  ++G    +++   H+      +  LR   QL DV L +  +  PA     HKVVLA+
Sbjct: 29  TADKNGALKCTFSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPA-----HKVVLAA 83

Query: 103 SSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMY 162
            S  F+AMFT G+RE   +V+ ++G+  + +  +I+FAY+A +++   CV  V+  AV  
Sbjct: 84  CSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFL 143

Query: 163 QIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFN 222
           Q+  VV  C +FL   +     + I   A       L +    + + HF ++A++E+F  
Sbjct: 144 QMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLR 203

Query: 223 LSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQ 282
           L   +LV  +  + L    E ++F A + W+++D   RR     +L  +R   +  + L 
Sbjct: 204 LPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELV 262

Query: 283 MQLQKCEILQSDSRCKDYLVKI-------FEELTLHKPTQVMPCRAPKV---GRLIYTAG 332
             +Q  +I+  D  C+ YL++        F +  +  P   +    P +   G   YT  
Sbjct: 263 DSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDS 322

Query: 333 GYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRN---NSPDGNTD 389
                S  Y +   P    +  L +++V  S     V+   +Y  GG++    S +G  D
Sbjct: 323 DRSVSSKVY-QLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVD 381

Query: 390 SSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDE 449
             A   Y+P  N+W     M   R +  + V+ G +YA GG +      SVERY P R+E
Sbjct: 382 --ACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNE 439

Query: 450 WHLVAPMLTRRIGVGVAVLNRLLYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRS 508
           W     +  R  G   A     LY  GG+        +  CY P  ++W     M+  R 
Sbjct: 440 WGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRV 499

Query: 509 GAGVCVLHNCIYAAGG----YDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
              +      IYA GG     D    + +VE Y  ET+ WT V+PM+  +S  G  + + 
Sbjct: 500 LHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLER 559

Query: 565 RIYVLGGYDG--HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
           +IY++GGY+   +     V+ Y+ DTD W          +G+  A  + P
Sbjct: 560 KIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLP 609


>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
           sapiens]
          Length = 589

 Score =  214 bits (545), Expect = 2e-55
 Identities = 150/545 (27%), Positives = 252/545 (46%), Gaps = 27/545 (4%)

Query: 67  MNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLRE-QGMEVVSI 125
           +N LR  +   DV L      A    F  H+ VLA+ S  F+AMF+ GL+E Q  EV   
Sbjct: 36  LNLLRQQRLFTDVLLH-----AGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFD 90

Query: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
             IHP+V+E L+++AY++ + + E+    ++    M +   +  AC++FL + L P+N +
Sbjct: 91  NSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 150

Query: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
           G+   ++   C +L++ +      +F  + K E+F  L    +V L+S ++L    E  V
Sbjct: 151 GMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLV 210

Query: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYL---V 302
           + + INW+ YD ++R  Y+  LL+ VR   L   +L   +   E++    + K+ +   +
Sbjct: 211 YESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAI 270

Query: 303 KIFEELTLHKPTQVMPCRAP-KVGRLIYTAGGY-FRQSLSYLEAYNPSDGTWLRLADLQV 360
           +   ++  +       C  P K G  ++  GG  F     YL      +   +  AD+  
Sbjct: 271 RCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKE--IIPKADIPS 328

Query: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
           PR   + C +G  +Y  GGR +    N  S  +  Y+ +  +WS  APM V R   G   
Sbjct: 329 PRKEFSACAIGCKVYITGGRGSE---NGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAE 385

Query: 421 IDGHIYAVGG---SHGC------IHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
           +   +Y VGG   + GC      +    VE Y+P  ++W +VAP+        V      
Sbjct: 386 LKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLK 445

Query: 472 LYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ 530
           L+A GG     ++L   +CY    N W +              VL N I+  GG D +  
Sbjct: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFS 504

Query: 531 LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDT 590
             S  +++ ET  WT V  +  +R +        ++YV+GGY G     +++CYDP  D 
Sbjct: 505 ACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564

Query: 591 WSEVT 595
           W+ +T
Sbjct: 565 WNSIT 569



 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 45/169 (26%), Positives = 70/169 (41%), Gaps = 10/169 (5%)

Query: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
           SL  +E Y+P+   W  +A L+   S  A       L+A GG + S D       + CY+
Sbjct: 410 SLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHD---KLPKVQCYD 466

Query: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGS---HGCIHHNSVERYEPERDEWHLVA 454
              N+W+  A    P       V+   I+ +GG      C    S  ++  E  +W  V 
Sbjct: 467 QCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSAC----SAYKFNSETYQWTKVG 522

Query: 455 PMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAM 503
            +  +R+          LY VGG+ G  R  + +CY P  + W  IT +
Sbjct: 523 DVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTV 571



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 31/110 (28%), Positives = 45/110 (40%), Gaps = 10/110 (9%)

Query: 507 RSGAGVCVLHNCIYAAGGYDGQDQLNS-VERYDVETETWTFVAPMKHRRSALGITVHQGR 565
           R     C +   +Y  GG   ++ ++  V  YD   E W+  APM   R   G    +  
Sbjct: 330 RKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHC 389

Query: 566 IYVLGGYDGHT---------FLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
           +YV+GG+   T          L  VE YDP  + W+ V  +  G S   V
Sbjct: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAV 439


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.136    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,431,188
Number of Sequences: 37866
Number of extensions: 1097296
Number of successful extensions: 3577
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 2074
Number of HSP's gapped (non-prelim): 412
length of query: 624
length of database: 18,247,518
effective HSP length: 108
effective length of query: 516
effective length of database: 14,157,990
effective search space: 7305522840
effective search space used: 7305522840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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