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Search of human proteins with 4507047
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
(629 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507047 solute carrier family 7 (cationic amino acid transpor... 1241 0.0
gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo s... 744 0.0
gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo s... 725 0.0
gi|114326550 solute carrier family 7 (cationic amino acid transp... 724 0.0
gi|114326544 solute carrier family 7 (cationic amino acid transp... 724 0.0
gi|110347453 solute carrier family 7 (cationic amino acid transp... 461 e-129
gi|181337167 solute carrier family 7 (cationic amino acid transp... 411 e-115
gi|187423910 solute carrier family 7, member 9 [Homo sapiens] 100 3e-21
gi|7657591 solute carrier family 7, member 9 [Homo sapiens] 100 3e-21
gi|71979932 solute carrier family 7 (cationic amino acid transpo... 100 3e-21
gi|7657683 solute carrier family 7, (cationic amino acid transpo... 99 2e-20
gi|33286428 solute carrier family 7 (cationic amino acid transpo... 93 6e-19
gi|186910308 solute carrier family 7 member 7 [Homo sapiens] 90 5e-18
gi|186910306 solute carrier family 7 member 7 [Homo sapiens] 90 5e-18
gi|186910304 solute carrier family 7 member 7 [Homo sapiens] 90 5e-18
gi|115648063 solute carrier family 7 (cationic amino acid transp... 90 7e-18
gi|115648022 solute carrier family 7 (cationic amino acid transp... 90 7e-18
gi|9790235 solute carrier family 7, member 10 [Homo sapiens] 84 3e-16
gi|71999149 solute carrier family 7, (cationic amino acid transp... 63 7e-10
gi|38569457 solute carrier family 12, member 8 [Homo sapiens] 59 1e-08
gi|33286430 solute carrier family 7 (cationic amino acid transpo... 52 2e-06
gi|31881740 solute carrier family 12 (potassium/chloride transpo... 47 5e-05
gi|134254459 sodium potassium chloride cotransporter 2 [Homo sap... 46 9e-05
gi|110224458 solute carrier family 12, member 6 isoform e [Homo ... 40 0.005
gi|110224456 solute carrier family 12, member 6 isoform d [Homo ... 40 0.005
gi|110224454 solute carrier family 12, member 6 isoform c [Homo ... 40 0.005
gi|110224452 solute carrier family 12, member 6 isoform c [Homo ... 40 0.005
gi|4826780 solute carrier family 12, member 6 isoform b [Homo sa... 40 0.005
gi|110224449 solute carrier family 12, member 6 isoform a [Homo ... 40 0.005
gi|4506975 solute carrier family 12 (sodium/potassium/chloride t... 39 0.019
>gi|4507047 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 1 [Homo sapiens]
Length = 629
Score = 1241 bits (3212), Expect = 0.0
Identities = 629/629 (100%), Positives = 629/629 (100%)
Query: 1 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE 60
MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE
Sbjct: 1 MGCKVLLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARE 60
Query: 61 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS 120
NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS
Sbjct: 61 NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILS 120
Query: 121 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT 180
YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT
Sbjct: 121 YIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLT 180
Query: 181 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG 240
LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG
Sbjct: 181 LGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEG 240
Query: 241 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA 300
KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA
Sbjct: 241 KPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIA 300
Query: 301 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR 360
YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR
Sbjct: 301 YFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPR 360
Query: 361 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY 420
VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY
Sbjct: 361 VIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAY 420
Query: 421 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI 480
SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI
Sbjct: 421 SLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTI 480
Query: 481 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA 540
LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA
Sbjct: 481 LSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA 540
Query: 541 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY 600
VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY
Sbjct: 541 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY 600
Query: 601 FGYGLWHSEEASLDADQARTPDGNLDQCK 629
FGYGLWHSEEASLDADQARTPDGNLDQCK
Sbjct: 601 FGYGLWHSEEASLDADQARTPDGNLDQCK 629
>gi|134304858 solute carrier family 7, member 2 isoform 2 [Homo
sapiens]
Length = 658
Score = 744 bits (1922), Expect = 0.0
Identities = 383/615 (62%), Positives = 475/615 (77%), Gaps = 11/615 (1%)
Query: 3 CKVLLNIGQQMLRRKVVDC-SREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVAREN 61
C+ L + ++RRK+V S E+T+L RCL+T DL+ALGVGSTLGAGVYVLAG VA+ +
Sbjct: 4 CRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKAD 63
Query: 62 AGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSY 121
+GP+IV+SFLIAALASV+AGLCY EFGARVPKTGSAYLY+YVTVGELWAFITGWNLILSY
Sbjct: 64 SGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSY 123
Query: 122 IIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTL 181
+IGTSSVARAWS TFDEL+ + IG+F RT+ +N G LAE PD FAV +IL+L GLL+
Sbjct: 124 VIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGLLSF 182
Query: 182 GVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGK 241
GVKESA VNK+FT +N+LVL F+MV+GFVKG+V NW+++EE N S ++ G
Sbjct: 183 GVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISAS-AREPPSENGT 241
Query: 242 P--GVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFI 299
G GGFMP+GF+G L+GAATCFYAFVGFDCIATTGEEV+NPQKAIP+GIV SLL+CF+
Sbjct: 242 SIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFM 301
Query: 300 AYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMP 359
AYFGVSAALTLMMPY+ LD SPLP AF++VGW AKY VA GSLCALS SLLGS+FPMP
Sbjct: 302 AYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSIFPMP 361
Query: 360 RVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLA 419
RVIYAMAEDGLLFK LA +N +TKTPIIATL+SGAVAA+MAFLFDLK LVD+MSIGTL+A
Sbjct: 362 RVIYAMAEDGLLFKCLAQINSKTKTPIIATLSSGAVAALMAFLFDLKALVDMMSIGTLMA 421
Query: 420 YSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQN-ELASTNDSQLGFLPEAEMFSLK 478
YSLVAACVL+LRY QP L Y S E D + + S ++SQ+ L + + FS++
Sbjct: 422 YSLVAACVLILRY---QPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTML-QRQGFSMR 477
Query: 479 TILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALL 538
T+ P ++ P++ S +V+ +A L++ ++T G A+T+ W++ LLA +L
Sbjct: 478 TLFCP-SLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVL 536
Query: 539 CAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFI 598
+ IWR P+++ K++F VPFLP LP SI VN+YLM+QL TWVRF++WM IGF+
Sbjct: 537 FVAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFL 596
Query: 599 IYFGYGLWHSEEASL 613
IYF YG+ HS E L
Sbjct: 597 IYFSYGIRHSLEGHL 611
>gi|109948288 solute carrier family 7, member 2 isoform 1 [Homo
sapiens]
Length = 697
Score = 725 bits (1871), Expect = 0.0
Identities = 371/615 (60%), Positives = 471/615 (76%), Gaps = 12/615 (1%)
Query: 3 CKVLLNIGQQMLRRKVVDC-SREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVAREN 61
C+ L + ++RRK+V S E+T+L RCL+T DL+ALGVGSTLGAGVYVLAG VA+ +
Sbjct: 44 CRAALTFARCLIRRKIVTLDSLEDTKLCRCLSTMDLIALGVGSTLGAGVYVLAGEVAKAD 103
Query: 62 AGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSY 121
+GP+IV+SFLIAALASV+AGLCY EFGARVPKTGSAYLY+YVTVGELWAFITGWNLILSY
Sbjct: 104 SGPSIVVSFLIAALASVMAGLCYAEFGARVPKTGSAYLYTYVTVGELWAFITGWNLILSY 163
Query: 122 IIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTL 181
+IGTSSVARAWS TFDEL+ + IG+F RT+ +N G LAE PD FAV +IL+L GLL+
Sbjct: 164 VIGTSSVARAWSGTFDELLSKQIGQFLRTYFRMNYTG-LAEYPDFFAVCLILLLAGLLSF 222
Query: 182 GVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGK 241
GVKESA VNK+FT +N+LVL F+MV+GFVKG+V NW+++EE N S ++ G
Sbjct: 223 GVKESAWVNKVFTAVNILVLLFVMVAGFVKGNVANWKISEEFLKNISAS-AREPPSENGT 281
Query: 242 P--GVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFI 299
G GGFMP+GF+G L+GAATCFYAFVGFDCIATTGEEV+NPQKAIP+GIV SLL+CF+
Sbjct: 282 SIYGAGGFMPYGFTGTLAGAATCFYAFVGFDCIATTGEEVRNPQKAIPIGIVTSLLVCFM 341
Query: 300 AYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMP 359
AYFGVSAALTLMMPY+ LD SPLP AF++VGW AKY VA GSLCALS SLLGSMFP+P
Sbjct: 342 AYFGVSAALTLMMPYYLLDEKSPLPVAFEYVGWGPAKYVVAAGSLCALSTSLLGSMFPLP 401
Query: 360 RVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLA 419
R+++AMA DGLLF+FLA V+ R ++P+ ATL +G ++A+MAFLFDLK LVD+MSIGTL+A
Sbjct: 402 RILFAMARDGLLFRFLARVSKR-QSPVAATLTAGVISALMAFLFDLKALVDMMSIGTLMA 460
Query: 420 YSLVAACVLVLRYQPEQPNLVYQMASTSDELDPADQN-ELASTNDSQLGFLPEAEMFSLK 478
YSLVAACVL+LRY QP L Y S E D + + S ++SQ+ L + + FS++
Sbjct: 461 YSLVAACVLILRY---QPGLSYDQPKCSPEKDGLGSSPRVTSKSESQVTML-QRQGFSMR 516
Query: 479 TILSPKNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALL 538
T+ P ++ P++ S +V+ +A L++ ++T G A+T+ W++ LLA +L
Sbjct: 517 TLFCP-SLLPTQQSASLVSFLVGFLAFLVLGLSVLTTYGVHAITRLEAWSLALLALFLVL 575
Query: 539 CAVVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFI 598
+ IWR P+++ K++F VPFLP LP SI VN+YLM+QL TWVRF++WM IGF+
Sbjct: 576 FVAIVLTIWRLPQNQQKVAFMVPFLPFLPAFSILVNIYLMVQLSADTWVRFSIWMAIGFL 635
Query: 599 IYFGYGLWHSEEASL 613
IYF YG+ HS E L
Sbjct: 636 IYFSYGIRHSLEGHL 650
>gi|114326550 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 724 bits (1869), Expect = 0.0
Identities = 378/612 (61%), Positives = 458/612 (74%), Gaps = 41/612 (6%)
Query: 10 GQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVIS 69
GQ+++RR+ ++ ETRL+RCL+T DLVALGVGSTLGAGVYVLAG VA++ AGP+IVI
Sbjct: 10 GQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVIC 69
Query: 70 FLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVA 129
FL+AAL+SVLAGLCY EFGARVP++GSAYLYSYVTVGELWAF TGWNLILSY+IGT+SVA
Sbjct: 70 FLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVA 129
Query: 130 RAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMV 189
RAWS+ FD LIG I + + + L+ P VLAE PD FA+ ++L+LTGLL LG ESA+V
Sbjct: 130 RAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALV 189
Query: 190 NKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKE-GKPGVGGFM 248
K+FT +N+LVLGF+M+SGFVKG V NW+LTEED+ L NDT G G GGF+
Sbjct: 190 TKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAEL---NDTYSLGPLGSGGFV 246
Query: 249 PFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAAL 308
PFGF G+L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL +CF+AYF VS+AL
Sbjct: 247 PFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSAL 306
Query: 309 TLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAED 368
TLMMPY+ L SPLP+AF ++GW A+Y VAVGSLCALS SLLGSMFPMPRVIYAMAED
Sbjct: 307 TLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAED 366
Query: 369 GLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVL 428
GLLF+ LA ++ T+TPIIAT+ SG +AA MAFLF L DLVDLMSIGTLLAYSLV+ CVL
Sbjct: 367 GLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVL 426
Query: 429 VLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEP 488
+LRYQP+Q T +E++ Q E +T E+E +L + P N P
Sbjct: 427 ILRYQPDQE------TKTGEEVEL--QEEAITT---------ESEKLTLWGLFFPLNSIP 469
Query: 489 SKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVT----- 543
+ +SG IV + +SL+AVL+ C+V A W+V LL+G L AVV
Sbjct: 470 TPLSGQIVYVCSSLLAVLLTALCLVL----------AQWSVPLLSGDLLWTAVVVLLLLL 519
Query: 544 -----GVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFI 598
VIWRQP+S T L FKVP LP+LP++SIFVN+YLMMQ+ GTW RF VWMLIGF
Sbjct: 520 IIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFA 579
Query: 599 IYFGYGLWHSEE 610
IYFGYG+ HS E
Sbjct: 580 IYFGYGIQHSLE 591
>gi|114326544 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 3 [Homo sapiens]
Length = 619
Score = 724 bits (1869), Expect = 0.0
Identities = 378/612 (61%), Positives = 458/612 (74%), Gaps = 41/612 (6%)
Query: 10 GQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVIS 69
GQ+++RR+ ++ ETRL+RCL+T DLVALGVGSTLGAGVYVLAG VA++ AGP+IVI
Sbjct: 10 GQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVIC 69
Query: 70 FLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVA 129
FL+AAL+SVLAGLCY EFGARVP++GSAYLYSYVTVGELWAF TGWNLILSY+IGT+SVA
Sbjct: 70 FLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVA 129
Query: 130 RAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMV 189
RAWS+ FD LIG I + + + L+ P VLAE PD FA+ ++L+LTGLL LG ESA+V
Sbjct: 130 RAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALV 189
Query: 190 NKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKE-GKPGVGGFM 248
K+FT +N+LVLGF+M+SGFVKG V NW+LTEED+ L NDT G G GGF+
Sbjct: 190 TKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAEL---NDTYSLGPLGSGGFV 246
Query: 249 PFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAAL 308
PFGF G+L GAATCFYAFVGFDCIATTGEE +NPQ++IP+GIV SL +CF+AYF VS+AL
Sbjct: 247 PFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSAL 306
Query: 309 TLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAED 368
TLMMPY+ L SPLP+AF ++GW A+Y VAVGSLCALS SLLGSMFPMPRVIYAMAED
Sbjct: 307 TLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAED 366
Query: 369 GLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVL 428
GLLF+ LA ++ T+TPIIAT+ SG +AA MAFLF L DLVDLMSIGTLLAYSLV+ CVL
Sbjct: 367 GLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVL 426
Query: 429 VLRYQPEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTILSPKNMEP 488
+LRYQP+Q T +E++ Q E +T E+E +L + P N P
Sbjct: 427 ILRYQPDQE------TKTGEEVEL--QEEAITT---------ESEKLTLWGLFFPLNSIP 469
Query: 489 SKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCAVVT----- 543
+ +SG IV + +SL+AVL+ C+V A W+V LL+G L AVV
Sbjct: 470 TPLSGQIVYVCSSLLAVLLTALCLVL----------AQWSVPLLSGDLLWTAVVVLLLLL 519
Query: 544 -----GVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFI 598
VIWRQP+S T L FKVP LP+LP++SIFVN+YLMMQ+ GTW RF VWMLIGF
Sbjct: 520 IIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFA 579
Query: 599 IYFGYGLWHSEE 610
IYFGYG+ HS E
Sbjct: 580 IYFGYGIQHSLE 591
>gi|110347453 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 4 [Homo sapiens]
Length = 635
Score = 461 bits (1185), Expect = e-129
Identities = 251/610 (41%), Positives = 365/610 (59%), Gaps = 33/610 (5%)
Query: 6 LLNIGQQMLRRKVVDCSREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPA 65
L + Q++ R K ++ S ET L RCL+T DL LGVG +G+G+YVL GAVA+E AGPA
Sbjct: 11 LARLCQKLNRLKPLEDSTMETSLRRCLSTLDLTLLGVGGMVGSGLYVLTGAVAKEVAGPA 70
Query: 66 IVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGT 125
+++SF +AA+AS+LA LCY EFGARVP+TGSAYL++YV++GELWAF+ GWN++L YIIG
Sbjct: 71 VLLSFGVAAVASLLAALCYAEFGARVPRTGSAYLFTYVSMGELWAFLIGWNVLLEYIIGG 130
Query: 126 SSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKE 185
++VARAWS D + I F+ TH+ +L PD A IIL+ + ++ G +
Sbjct: 131 AAVARAWSGYLDSMFSHSIRNFTETHVGSWQVPLLGHYPDFLAAGIILLASAFVSCGARV 190
Query: 186 SAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVG 245
S+ +N F+ I++LV+ FI++ GF+ NW E G
Sbjct: 191 SSWLNHTFSAISLLVILFIVILGFILAQPHNWSADE-----------------------G 227
Query: 246 GFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVS 305
GF PFGFSGV++G A+CFYAFVGFD IA + EE +NP++++P+ I SL I AY VS
Sbjct: 228 GFAPFGFSGVMAGTASCFYAFVGFDVIAASSEEAQNPRRSVPLAIAISLAIAAGAYILVS 287
Query: 306 AALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAM 365
LTLM+P+ LD +S L DAF G+ A + VA GS+CA++ LL +F +PR++YAM
Sbjct: 288 TVLTLMVPWHSLDPDSALADAFYQRGYRWAGFIVAAGSICAMNTVLLSLLFSLPRIVYAM 347
Query: 366 AEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAA 425
A DGL F+ A+V+ RT+ P+ TLA G + A +A L DL+ LV +S+GTLLAY+ VA
Sbjct: 348 AADGLFFQVFAHVHPRTQVPVAGTLAFGLLTAFLALLLDLESLVQFLSLGTLLAYTFVAT 407
Query: 426 CVLVLRYQ----PEQPNLVYQMASTSDELDPADQNELASTNDSQLGFLPEAEMFSLKTIL 481
++VLR+Q P P T + +D +L T + + E LK L
Sbjct: 408 SIIVLRFQKSSPPSSPGPASPGPLTKQQSSFSDHLQLVGTVHASV-----PEPGELKPAL 462
Query: 482 SP-KNMEPSKISGLIVNISTSLIAVLIITFCIVTVLGREALTKGALWAVFLLAGSALLCA 540
P G +V + ++ IT V V G L + LL ++++
Sbjct: 463 RPYLGFLDGYSPGAVVTWALGVMLASAITIGCVLVFGNSTLHLPHWGYILLLLLTSVMFL 522
Query: 541 VVTGVIWRQPESKTKLSFKVPFLPVLPILSIFVNVYLMMQLDQGTWVRFAVWMLIGFIIY 600
+ V+ + + F++P +P++P LSI +N+ LM++L TWVRF++W+L+G +Y
Sbjct: 523 LSLLVLGAHQQQYREDLFQIPMVPLIPALSIVLNICLMLKLSYLTWVRFSIWLLMGLAVY 582
Query: 601 FGYGLWHSEE 610
FGYG+ HS+E
Sbjct: 583 FGYGIRHSKE 592
>gi|181337167 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 14 [Homo sapiens]
Length = 771
Score = 411 bits (1057), Expect = e-115
Identities = 216/413 (52%), Positives = 286/413 (69%), Gaps = 28/413 (6%)
Query: 26 TRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVISFLIAALASVLAGLCYG 85
T+L++ L T DL++LGVGS +G G+YV++G VA+E AGP +++SF+IAA+AS+L+G+CY
Sbjct: 47 TKLAQVLTTVDLISLGVGSCVGTGMYVVSGLVAKEMAGPGVIVSFIIAAVASILSGVCYA 106
Query: 86 EFGARVPKT-GSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPI 144
EFG RVPKT GSAY YSYVTVGE AF GWNLIL Y+IGT++ A A S+ FD L I
Sbjct: 107 EFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTAAGASALSSMFDSLANHTI 166
Query: 145 GEFSRTHM-TLNAPGVLAEN-PDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLG 202
+ + TLN G E+ PD+ A++I +I+T ++ LGVK S N + +N+ V
Sbjct: 167 SRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGFNNVLNVLNLAVWV 226
Query: 203 FIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATC 262
FIM++G + K W G F+P G+SGVL GAATC
Sbjct: 227 FIMIAGLFFINGKYW-------------------------AEGQFLPHGWSGVLQGAATC 261
Query: 263 FYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSP 322
FYAF+GFD IATTGEE KNP +IP I ASL+IC AY VS LTLM+PY+ +D SP
Sbjct: 262 FYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESP 321
Query: 323 LPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRT 382
L + F G+ AK+ VA+GS+ L+ SLLGS+FPMPRVIYAMA DGLLF+FLA+V+ T
Sbjct: 322 LMEMFVAHGFYAAKFVVAIGSVAGLTVSLLGSLFPMPRVIYAMAGDGLLFRFLAHVSSYT 381
Query: 383 KTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPE 435
+TP++A + SG +AA++A L L+DL+++MSIGTLLAY+LV+ CVL+LRYQPE
Sbjct: 382 ETPVVACIVSGFLAALLALLVSLRDLIEMMSIGTLLAYTLVSVCVLLLRYQPE 434
>gi|187423910 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 100 bits (250), Expect = 3e-21
Identities = 91/412 (22%), Positives = 181/412 (43%), Gaps = 42/412 (10%)
Query: 26 TRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVAR--ENAGPAIVISFLIAALASVLAGLC 83
T L + L +++ VG+ +G+G++V +V E GP ++I LA+ L LC
Sbjct: 24 TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLAT-LGALC 82
Query: 84 YGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRP 143
+ E G + K+G Y Y G + A++ W ++ +I +S A +F E + P
Sbjct: 83 FAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLI--VIKPTSFAII-CLSFSEYVCAP 139
Query: 144 IGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGF 203
++ P ++ + A IL ++ + +L V+ + V IFT ++++
Sbjct: 140 F------YVGCKPPQIVVK---CLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAI 190
Query: 204 IMVSGFV---KGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAA 260
I++SG V +G+ KN+ +N + + VG ++G+
Sbjct: 191 IIISGLVLLAQGNTKNF----------------DNSFEGAQLSVGAISLAFYNGL----- 229
Query: 261 TCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNN 320
+A+ G++ + EE++NP + +P+ I+ + + Y ++ + +M L +
Sbjct: 230 ---WAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQS 286
Query: 321 SPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVND 380
+ F A + V + + + G+ F R+IY +G + K L+ ++
Sbjct: 287 QAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISV 346
Query: 381 RTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY 432
R TP A + G +A + D+ LV+ S L Y L ++V+R+
Sbjct: 347 RRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF 398
>gi|7657591 solute carrier family 7, member 9 [Homo sapiens]
Length = 487
Score = 100 bits (250), Expect = 3e-21
Identities = 91/412 (22%), Positives = 181/412 (43%), Gaps = 42/412 (10%)
Query: 26 TRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVAR--ENAGPAIVISFLIAALASVLAGLC 83
T L + L +++ VG+ +G+G++V +V E GP ++I LA+ L LC
Sbjct: 24 TSLQKELGLISGISIIVGTIIGSGIFVSPKSVLSNTEAVGPCLIIWAACGVLAT-LGALC 82
Query: 84 YGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRP 143
+ E G + K+G Y Y G + A++ W ++ +I +S A +F E + P
Sbjct: 83 FAELGTMITKSGGEYPYLMEAYGPIPAYLFSWASLI--VIKPTSFAII-CLSFSEYVCAP 139
Query: 144 IGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGF 203
++ P ++ + A IL ++ + +L V+ + V IFT ++++
Sbjct: 140 F------YVGCKPPQIVVK---CLAAAAILFISTVNSLSVRLGSYVQNIFTAAKLVIVAI 190
Query: 204 IMVSGFV---KGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAA 260
I++SG V +G+ KN+ +N + + VG ++G+
Sbjct: 191 IIISGLVLLAQGNTKNF----------------DNSFEGAQLSVGAISLAFYNGL----- 229
Query: 261 TCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNN 320
+A+ G++ + EE++NP + +P+ I+ + + Y ++ + +M L +
Sbjct: 230 ---WAYDGWNQLNYITEELRNPYRNLPLAIIIGIPLVTACYILMNVSYFTVMTATELLQS 286
Query: 321 SPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVND 380
+ F A + V + + + G+ F R+IY +G + K L+ ++
Sbjct: 287 QAVAVTFGDRVLYPASWIVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISV 346
Query: 381 RTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY 432
R TP A + G +A + D+ LV+ S L Y L ++V+R+
Sbjct: 347 RRLTPAPAIIFYGIIATIYIIPGDINSLVNYFSFAAWLFYGLTILGLIVMRF 398
>gi|71979932 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 5 [Homo sapiens]
Length = 507
Score = 100 bits (250), Expect = 3e-21
Identities = 105/434 (24%), Positives = 186/434 (42%), Gaps = 47/434 (10%)
Query: 11 QQMLRRKVVDCSR-----EETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPA 65
++ML K D S E L R + + VA+ VG+ +G+G++V V +E P
Sbjct: 24 EKMLAAKSADGSAPAGEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPG 83
Query: 66 I-VISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIG 124
+ ++ + + S++ LCY E G + K+G Y Y G L AF+ W + +I
Sbjct: 84 LALVVWAACGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLW---IELLII 140
Query: 125 TSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVK 184
S + F + +P+ T P E + A + +L+LT + VK
Sbjct: 141 RPSSQYIVALVFATYLLKPL------FPTCPVP---EEAAKLVACLCVLLLTAVNCYSVK 191
Query: 185 ESAMVNKIFTCINVLVLGFIMVSGFV---KGSVKNWQLTEEDFGNTSGRLCLNNDTKEGK 241
+ V F +L L I++ GFV KG V N L N + K
Sbjct: 192 AATRVQDAFAAAKLLALALIILLGFVQIGKGDVSN--------------LDPNFSFEGTK 237
Query: 242 PGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAY 301
VG + +SG+ +A+ G++ + EE+ NP + +P+ I+ SL I + Y
Sbjct: 238 LDVGNIVLALYSGL--------FAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVY 289
Query: 302 FGVSAA-LTLMMPYFCLDNNSPLPD-AFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMP 359
+ A T + L + + D H+G V VG C S+ GS+F
Sbjct: 290 VLTNLAYFTTLSTEQMLSSEAVAVDFGNYHLGVMSWIIPVFVGLSC--FGSVNGSLFTSS 347
Query: 360 RVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLA 419
R+ + + +G L L+ ++ + TP+ + + + + + AF D+ +++ S L
Sbjct: 348 RLFFVGSREGHLPSILSMIHPQLLTPVPSLVFTCVMTLLYAFSKDIFSVINFFSFFNWLC 407
Query: 420 YSLVAACVLVLRYQ 433
+L ++ LR++
Sbjct: 408 VALAIIGMIWLRHR 421
>gi|7657683 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 11 [Homo sapiens]
Length = 501
Score = 98.6 bits (244), Expect = 2e-20
Identities = 97/419 (23%), Positives = 180/419 (42%), Gaps = 48/419 (11%)
Query: 23 REETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVIS-FLIAALASVLAG 81
+E+ +L R + V++ +G+ +GAG+++ V + + ++ + + + S+
Sbjct: 35 QEKVQLKRKVTLLRGVSIIIGTIIGAGIFISPKGVLQNTGSVGMSLTIWTVCGVLSLFGA 94
Query: 82 LCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIG 141
L Y E G + K+G Y Y G L AF+ W +L II ++ A S F I
Sbjct: 95 LSYAELGTTIKKSGGHYTYILEVFGPLPAFVRVWVELL--IIRPAATA-VISLAFGRYIL 151
Query: 142 RPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVL 201
P + P + + + ++++L ++ V SA + T + +
Sbjct: 152 EPF------FIQCEIPELAIKLITAVGITVVMVLN---SMSVSWSARIQIFLTFCKLTAI 202
Query: 202 GFIMVSG---FVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSG 258
I+V G +KG +N++ D G+ +P F +
Sbjct: 203 LIIIVPGVMQLIKGQTQNFK-----------------DAFSGRDSSITRLPLAFYYGM-- 243
Query: 259 AATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYF--GVSAALTLMMPYFC 316
YA+ G+ + EEV+NP+K IP+ I S+ I I Y V+ T+
Sbjct: 244 -----YAYAGWFYLNFVTEEVENPEKTIPLAICISMAIVTIGYVLTNVAYFTTINAEELL 298
Query: 317 LDNNSPLPDAFKHVGWEGAKYAVAVGSLCALS--ASLLGSMFPMPRVIYAMAEDGLLFKF 374
L N + + + +G +++AV ALS S+ G +F + R+ Y + +G L +
Sbjct: 299 LSNAVAVTFSERLLG----NFSLAVPIFVALSCFGSMNGGVFAVSRLFYVASREGHLPEI 354
Query: 375 LANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQ 433
L+ ++ R TP+ A + + +M F DL L++ +S L L A ++ LRY+
Sbjct: 355 LSMIHVRKHTPLPAVIVLHPLTMIMLFSGDLDSLLNFLSFARWLFIGLAVAGLIYLRYK 413
>gi|33286428 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform a [Homo
sapiens]
Length = 535
Score = 93.2 bits (230), Expect = 6e-19
Identities = 103/403 (25%), Positives = 175/403 (43%), Gaps = 42/403 (10%)
Query: 42 VGSTLGAGVYVLAGAVARENAGPA--IVISFLIAALASVLAGLCYGEFGARVPKTGSAYL 99
VG+ +G+G++V V ENAG +I +++ +V+ LCY E G +PK+G Y
Sbjct: 50 VGNIIGSGIFVSPKGVL-ENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYS 108
Query: 100 YSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGV 159
Y G L F+ W +L +V + TF + +P+ T P
Sbjct: 109 YVKDIFGGLAGFLRLWIAVLVIYPTNQAVI---ALTFSNYVLQPL------FPTCFPP-- 157
Query: 160 LAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFV---KGSVKN 216
+ A I +L+LT + V+ + V IFT +L L I++ G V KG
Sbjct: 158 -ESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEY-F 215
Query: 217 WQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTG 276
W + F N +P + G + F L G+ +A+ G++ +
Sbjct: 216 WLEPKNAFENFQ------------EPDI-GLVALAF---LQGS----FAYGGWNFLNYVT 255
Query: 277 EEVKNPQKAIPVGIVASL-LICFIAYFGVSAALTLMMPYFCLDNNSPLPDAFKHVGWEGA 335
EE+ +P K +P I S+ L+ F+ F A +T M P L +N+ + F
Sbjct: 256 EELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNA-VAVTFGEKLLGVM 314
Query: 336 KYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRTKTPIIATLASGAV 395
+ + + + + GS+F R+ +A A +G L LA ++ + TPI A L +
Sbjct: 315 AWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCIS 374
Query: 396 AAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY-QPEQP 437
+M D+ L++ + L Y + A +VLR+ +P+ P
Sbjct: 375 TLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIP 417
>gi|186910308 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 90.1 bits (222), Expect = 5e-18
Identities = 103/426 (24%), Positives = 182/426 (42%), Gaps = 55/426 (12%)
Query: 24 EETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENA--GPAIVISFLIAALASVLAG 81
E+ +L + ++ + V L VG+ +G+G++V V +A G ++VI + + L SV
Sbjct: 29 EQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVFGA 87
Query: 82 LCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIG 141
LCY E G + K+G++Y Y G AFI W +L II +S A + TF +
Sbjct: 88 LCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-IIAITFANYMV 144
Query: 142 RPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVL 201
+P+ + AP + + A I +LT + VK +V IFT VL L
Sbjct: 145 QPL------FPSCFAPYAASR---LLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLAL 195
Query: 202 GFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAAT 261
++V+G V+ E F +S F + +
Sbjct: 196 IAVIVAGIVRLGQGASTHFENSFEGSS---------------------FAVGDIALALYS 234
Query: 262 CFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNS 321
+++ G+D + EE+KNP++ +P+ I S+ I I Y LT + Y LD
Sbjct: 235 ALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYI-----LTNVAYYTVLDMRD 289
Query: 322 PLPDAFKHVGWEGAKY---------AVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLF 372
L V + + +VA+ L+AS++ + R+ + + +G L
Sbjct: 290 ILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAA----SRLFFVGSREGHLP 345
Query: 373 KFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY 432
+ ++ TP+ + L +G +A + + D+ L++ S L L LR+
Sbjct: 346 DAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRW 405
Query: 433 -QPEQP 437
+P++P
Sbjct: 406 KEPDRP 411
>gi|186910306 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 90.1 bits (222), Expect = 5e-18
Identities = 103/426 (24%), Positives = 182/426 (42%), Gaps = 55/426 (12%)
Query: 24 EETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENA--GPAIVISFLIAALASVLAG 81
E+ +L + ++ + V L VG+ +G+G++V V +A G ++VI + + L SV
Sbjct: 29 EQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVFGA 87
Query: 82 LCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIG 141
LCY E G + K+G++Y Y G AFI W +L II +S A + TF +
Sbjct: 88 LCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-IIAITFANYMV 144
Query: 142 RPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVL 201
+P+ + AP + + A I +LT + VK +V IFT VL L
Sbjct: 145 QPL------FPSCFAPYAASR---LLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLAL 195
Query: 202 GFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAAT 261
++V+G V+ E F +S F + +
Sbjct: 196 IAVIVAGIVRLGQGASTHFENSFEGSS---------------------FAVGDIALALYS 234
Query: 262 CFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNS 321
+++ G+D + EE+KNP++ +P+ I S+ I I Y LT + Y LD
Sbjct: 235 ALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYI-----LTNVAYYTVLDMRD 289
Query: 322 PLPDAFKHVGWEGAKY---------AVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLF 372
L V + + +VA+ L+AS++ + R+ + + +G L
Sbjct: 290 ILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAA----SRLFFVGSREGHLP 345
Query: 373 KFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY 432
+ ++ TP+ + L +G +A + + D+ L++ S L L LR+
Sbjct: 346 DAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRW 405
Query: 433 -QPEQP 437
+P++P
Sbjct: 406 KEPDRP 411
>gi|186910304 solute carrier family 7 member 7 [Homo sapiens]
Length = 511
Score = 90.1 bits (222), Expect = 5e-18
Identities = 103/426 (24%), Positives = 182/426 (42%), Gaps = 55/426 (12%)
Query: 24 EETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENA--GPAIVISFLIAALASVLAG 81
E+ +L + ++ + V L VG+ +G+G++V V +A G ++VI + + L SV
Sbjct: 29 EQVKLKKEISLLNGVCLIVGNMIGSGIFVSPKGVLIYSASFGLSLVI-WAVGGLFSVFGA 87
Query: 82 LCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIG 141
LCY E G + K+G++Y Y G AFI W +L II +S A + TF +
Sbjct: 88 LCYAELGTTIKKSGASYAYILEAFGGFLAFIRLWTSLL--IIEPTSQA-IIAITFANYMV 144
Query: 142 RPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVL 201
+P+ + AP + + A I +LT + VK +V IFT VL L
Sbjct: 145 QPL------FPSCFAPYAASR---LLAAACICLLTFINCAYVKWGTLVQDIFTYAKVLAL 195
Query: 202 GFIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAAT 261
++V+G V+ E F +S F + +
Sbjct: 196 IAVIVAGIVRLGQGASTHFENSFEGSS---------------------FAVGDIALALYS 234
Query: 262 CFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNS 321
+++ G+D + EE+KNP++ +P+ I S+ I I Y LT + Y LD
Sbjct: 235 ALFSYSGWDTLNYVTEEIKNPERNLPLSIGISMPIVTIIYI-----LTNVAYYTVLDMRD 289
Query: 322 PLPDAFKHVGWEGAKY---------AVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLF 372
L V + + +VA+ L+AS++ + R+ + + +G L
Sbjct: 290 ILASDAVAVTFADQIFGIFNWIIPLSVALSCFGGLNASIVAA----SRLFFVGSREGHLP 345
Query: 373 KFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY 432
+ ++ TP+ + L +G +A + + D+ L++ S L L LR+
Sbjct: 346 DAICMIHVERFTPVPSLLFNGIMALIYLCVEDIFQLINYYSFSYWFFVGLSIVGQLYLRW 405
Query: 433 -QPEQP 437
+P++P
Sbjct: 406 KEPDRP 411
>gi|115648063 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 6 [Homo sapiens]
Length = 515
Score = 89.7 bits (221), Expect = 7e-18
Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 43/422 (10%)
Query: 22 SREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAI-VISFLIAALASVLA 80
S E +L + ++ + V+L VG+ +G+G++V V A + +I + I L SV+
Sbjct: 35 SSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVG 94
Query: 81 GLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGW-NLILSYIIGTSSVARAWSATFDEL 139
LCY E G + K+G++Y Y G AFI W +L++ G + +A TF
Sbjct: 95 ALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIA----ITFANY 150
Query: 140 IGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVL 199
I +P + + + P + + A I +LT + VK V FT V+
Sbjct: 151 IIQP------SFPSCDPPYLACR---LLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVV 201
Query: 200 VLGFIMVSGFVK---GSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVL 256
L I+V G VK G +++Q E G L L
Sbjct: 202 ALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSL----------------------- 238
Query: 257 SGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFC 316
+ +++ G+D + EE+KNP++ +P+ I S+ I + Y + A ++
Sbjct: 239 -ALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISD 297
Query: 317 LDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLA 376
+ ++ + F + + + + + L S+F R+ + + +G L L+
Sbjct: 298 VLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLS 357
Query: 377 NVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY-QPE 435
++ TPI A L + +A + + D+ L++ S L L LR+ +P+
Sbjct: 358 MIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPK 417
Query: 436 QP 437
+P
Sbjct: 418 RP 419
>gi|115648022 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 6 [Homo sapiens]
Length = 515
Score = 89.7 bits (221), Expect = 7e-18
Identities = 97/422 (22%), Positives = 178/422 (42%), Gaps = 43/422 (10%)
Query: 22 SREETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAI-VISFLIAALASVLA 80
S E +L + ++ + V+L VG+ +G+G++V V A + +I + I L SV+
Sbjct: 35 SSETMQLKKEISLLNGVSLVVGNMIGSGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVG 94
Query: 81 GLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGW-NLILSYIIGTSSVARAWSATFDEL 139
LCY E G + K+G++Y Y G AFI W +L++ G + +A TF
Sbjct: 95 ALCYAELGTTITKSGASYAYILEAFGGFIAFIRLWVSLLVVEPTGQAIIA----ITFANY 150
Query: 140 IGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVL 199
I +P + + + P + + A I +LT + VK V FT V+
Sbjct: 151 IIQP------SFPSCDPPYLACR---LLAAACICLLTFVNCAYVKWGTRVQDTFTYAKVV 201
Query: 200 VLGFIMVSGFVK---GSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVL 256
L I+V G VK G +++Q E G L L
Sbjct: 202 ALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSL----------------------- 238
Query: 257 SGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFC 316
+ +++ G+D + EE+KNP++ +P+ I S+ I + Y + A ++
Sbjct: 239 -ALYSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISD 297
Query: 317 LDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLA 376
+ ++ + F + + + + + L S+F R+ + + +G L L+
Sbjct: 298 VLSSDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLS 357
Query: 377 NVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY-QPE 435
++ TPI A L + +A + + D+ L++ S L L LR+ +P+
Sbjct: 358 MIHIERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPK 417
Query: 436 QP 437
+P
Sbjct: 418 RP 419
>gi|9790235 solute carrier family 7, member 10 [Homo sapiens]
Length = 523
Score = 84.3 bits (207), Expect = 3e-16
Identities = 94/417 (22%), Positives = 179/417 (42%), Gaps = 43/417 (10%)
Query: 24 EETRLSRCLNTFDLVALGVGSTLGAGVYVLAGAVARENAGPAIVIS-FLIAALASVLAGL 82
E L + + + +G+ +G+G+++ V + + + +++ + L L
Sbjct: 32 ERVALKKEIGLLSACTIIIGNIIGSGIFISPKGVLEHSGSVGLALFVWVLGGGVTALGSL 91
Query: 83 CYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGR 142
CY E G +PK+G Y Y G L F+ W+ +L I+ +S+A S TF + +
Sbjct: 92 CYAELGVAIPKSGGDYAYVTEIFGGLAGFLLLWSAVL--IMYPTSLA-VISMTFSNYVLQ 148
Query: 143 PIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLG 202
P+ F A VL ++ +++LT + + V+ + + +FT +L L
Sbjct: 149 PV--FPNCIPPTTASRVL-------SMACLMLLTWVNSSSVRWATRIQDMFTGGKLLALS 199
Query: 203 FIMVSGFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATC 262
I+ G + Q+ + F +E +P F + + A
Sbjct: 200 LIIGVGLL-------QIFQGHF-------------EELRP--SNAFAFWMTPSVGHLALA 237
Query: 263 F----YAFVGFDCIATTGEEVKNPQKAIPVGIVASL-LICFIAYFGVSAALTLMMPYFCL 317
F +AF G++ + EE+ + +K +P I S+ L+ F+ F A T M P L
Sbjct: 238 FLQGSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELL 297
Query: 318 DNNS-PLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLA 376
+N+ + K +G+ + + V + + G +F R+ ++ A +G L LA
Sbjct: 298 SSNAVAVTFGEKLLGY--FSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLA 355
Query: 377 NVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQ 433
++ R TPI A L AV+ + D L++ +S L Y + +L+LR++
Sbjct: 356 MIHVRHCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWR 412
>gi|71999149 solute carrier family 7, (cationic amino acid
transporter, y+ system) member 13 [Homo sapiens]
Length = 470
Score = 63.2 bits (152), Expect = 7e-10
Identities = 94/409 (22%), Positives = 176/409 (43%), Gaps = 62/409 (15%)
Query: 46 LGAGVYVLAGAVARE---NAGPAIVISFLIAALASVLAGLCYGEFGARVPKTGSAYLYSY 102
+GAG++V V N G ++ + + A+ ++ + LC E P +G+ Y +
Sbjct: 27 IGAGIFVSPKGVLAYSCMNVGVSLCV-WAGCAILAMTSTLCSAEISISFPCSGAQYYFLK 85
Query: 103 VTVGELWAFITGWNLILSYIIGTSSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAE 162
G AF+ W S +G+ VA + E +P + + P +
Sbjct: 86 RYFGSTVAFLNLWT---SLFLGSGVVA-GQALLLAEYSIQPF------FPSCSVPKL--- 132
Query: 163 NPDIFAVIIILILTGLLTL-GVKESAMVNKIFTCINVLVLGFIMVSGFV---KGSVKNWQ 218
P + +L + G+LT GVKE + + + V +L FI ++G V +G +N +
Sbjct: 133 -PKKCLALAMLWIVGILTSRGVKEVTWLQIASSVLKVSILSFISLTGVVFLIRGKKENVE 191
Query: 219 LTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEE 278
+ F P + + F G ++A+ G C E
Sbjct: 192 RFQNAFDAEL-------------PDISHLIQAIFQG--------YFAYSGGACFTLIAGE 230
Query: 279 VKNPQKAIPVGIVASLLICFIAYFGVSAA-LTLMMPYFCLDNNSP----LPDAFKHVGWE 333
+K P+ IP I +L + + Y V+ + LT++ P L +++ AF + W
Sbjct: 231 LKKPRTTIPKCIFTALPLVTVVYLLVNISYLTVLTPREILSSDAVAITWADRAFPSLAWI 290
Query: 334 GAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDG---LLFKFLANVNDRTKTPIIATL 390
+A++ +L ++LL S+F R IY +++G LLF L N + T ++ +
Sbjct: 291 -MPFAIST----SLFSNLLISIFKSSRPIYLASQEGQLPLLFNTL-NSHSSPFTAVLLLV 344
Query: 391 ASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRYQPEQPNL 439
G++A ++ L DL + + G+L + L+ + +LR + ++PNL
Sbjct: 345 TLGSLAIILTSLIDLINYI--FFTGSLWSILLM---IGILRRRYQEPNL 388
>gi|38569457 solute carrier family 12, member 8 [Homo sapiens]
Length = 714
Score = 59.3 bits (142), Expect = 1e-08
Identities = 87/362 (24%), Positives = 150/362 (41%), Gaps = 45/362 (12%)
Query: 67 VISFLI-AALASVLAGLCYGEFGARVPKTGSAYLYSYVTVGELWAFITGWNLILSYIIGT 125
++SF+I AL +VL+G+ GE + GS +YS ++ + TG + L Y+ G
Sbjct: 77 LVSFVILVALVTVLSGIGVGERSS----IGSGGVYSMIS--SVLGGQTGGTIGLLYVFGQ 130
Query: 126 SSVARAWSATFDELIGRPIGEFSRTHMTLNAPGVLAENPDIFAVIIILILTGLLTLGVKE 185
+ F E I +G +I+AV I + L LG+
Sbjct: 131 CVAGAMYITGFAESISDLLGL-----------------GNIWAVRGISVAVLLALLGINL 173
Query: 186 SAMVNKIFTCINVLVLGFIMVS--GFVKGSVKNWQLTEEDFGNTSGRLCLNNDTKEGKPG 243
+ + K + +L+L + VS FV GS + E F S L NN + PG
Sbjct: 174 AGV--KWIIRLQLLLLFLLAVSTLDFVVGSFTHLD-PEHGFIGYSPELLQNNTLPDYSPG 230
Query: 244 VGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQKAIPVGIVASLLICFIAYFG 303
F FG V AAT A GF+ G +++ P +IP+G +A++ I + Y
Sbjct: 231 ESFFTVFG---VFFPAATGVMA--GFNM----GGDLREPAASIPLGSLAAVGISWFLYIV 281
Query: 304 VSAALTLMMPYFCLDNNSPLPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIY 363
L + L + + + +G + +G + AS +G ++ PR++
Sbjct: 282 FVFLLGAICTREALRYDFLIAEKVSLMG-----FLFLLGLYISSLASCMGGLYGAPRILQ 336
Query: 364 AMAEDGLL--FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYS 421
+A++ ++ L KTP+ A + V F+ + L +++I +L Y
Sbjct: 337 CIAQEKVIPALACLGQGKGPNKTPVAAICLTSLVTMAFVFVGQVNVLAPIVTINFMLTYV 396
Query: 422 LV 423
V
Sbjct: 397 AV 398
>gi|33286430 solute carrier family 7 (cationic amino acid
transporter, y+ system), member 8 isoform b [Homo
sapiens]
Length = 332
Score = 52.0 bits (123), Expect = 2e-06
Identities = 45/176 (25%), Positives = 83/176 (47%), Gaps = 3/176 (1%)
Query: 264 YAFVGFDCIATTGEEVKNPQKAIPVGIVASL-LICFIAYFGVSAALTLMMPYFCLDNNSP 322
+A+ G++ + EE+ +P K +P I S+ L+ F+ F A +T M P L +N+
Sbjct: 40 FAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNA- 98
Query: 323 LPDAFKHVGWEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFLANVNDRT 382
+ F + + + + + GS+F R+ +A A +G L LA ++ +
Sbjct: 99 VAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKR 158
Query: 383 KTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY-QPEQP 437
TPI A L + +M D+ L++ + L Y + A +VLR+ +P+ P
Sbjct: 159 CTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIP 214
>gi|31881740 solute carrier family 12 (potassium/chloride
transporters), member 9 [Homo sapiens]
Length = 914
Score = 47.0 bits (110), Expect = 5e-05
Identities = 63/285 (22%), Positives = 116/285 (40%), Gaps = 30/285 (10%)
Query: 166 IFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKNWQLTEED-- 223
++ +++ ++ G+ TLG A + + + L +++S FV ++ +LT
Sbjct: 169 LYGSLLLGLVGGVCTLGAGLYARASFLTFLLVSGSLASVLIS-FVAVGPRDIRLTPRPGP 227
Query: 224 --------FGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGA---ATCFYAFVGFDCI 272
FG+ +G N+ T + G G + V++ A A F G
Sbjct: 228 NGSSLPPRFGHFTG---FNSSTLKDNLGAGYAEDYTTGAVMNFASVFAVLFNGCTGIMAG 284
Query: 273 ATTGEEVKNPQKAIPVGIVASLLICFIAYFGVSAALTLMMPYFCLDNNSPLPD--AFKHV 330
A E+K+P +AIP+G + ++ F Y L + F D D F+ +
Sbjct: 285 ANMSGELKDPSRAIPLGTIVAVAYTFFVY-----VLLFFLSSFTCDRTLLQEDYGFFRAI 339
Query: 331 G-WEGAKYAVAVGSLCALSASLLGSMFPMPRVIYAMAEDGLLFKFL--ANVNDRTKTPII 387
W V +G ++ + S+ R+++A+A D L L A V R P
Sbjct: 340 SLWPP---LVLIGIYATALSASMSSLIGASRILHALARDDLFGVILAPAKVVSRGGNPWA 396
Query: 388 ATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLVAACVLVLRY 432
A L S + ++ L L ++++ L+AY+ V L L +
Sbjct: 397 AVLYSWGLVQLVLLAGKLNTLAAVVTVFYLVAYAAVDLSCLSLEW 441
>gi|134254459 sodium potassium chloride cotransporter 2 [Homo
sapiens]
Length = 1099
Score = 46.2 bits (108), Expect = 9e-05
Identities = 62/294 (21%), Positives = 110/294 (37%), Gaps = 50/294 (17%)
Query: 166 IFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSV--KNWQLTEED 223
I I ++IL G+ G++ A I +LV+ I ++ F G+V N +
Sbjct: 303 IIGSITVVILLGISVAGMEWEAKAQVI-----LLVILLIAIANFFIGTVIPSNNEKKSRG 357
Query: 224 FGNTSGRLCLNNDTKEGKPGVGGFMPFGFSGVLSGAATCFYAFVGFDCIATTGEEVKNPQ 283
F N + N G G F F A F A G A ++++PQ
Sbjct: 358 FFNYQASIFAENFGPRFTKGEGFFSVF---------AIFFPAATGILAGANISGDLEDPQ 408
Query: 284 KAIPVGIVASLLICFIAYFGVSAAL--------------TLMMPYFCLDNNS-PLPDAFK 328
AIP G + ++ I +AY GV+ + T++ C + + L F
Sbjct: 409 DAIPRGTMLAIFITTVAYLGVAICVGACVVRDATGNMNDTIISGMNCNGSAACGLGYDFS 468
Query: 329 HVGWEGAKYA-----------------VAVGSLCALSASLLGSMFPMPRVIYAMAEDGL- 370
E +Y + G A +S L S+ P+V A+ +D +
Sbjct: 469 RCRHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIY 528
Query: 371 -LFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYSLV 423
+F A + P+ + + +A + +L + ++S L +Y+L+
Sbjct: 529 KALQFFAKGYGKNNEPLRGYILTFLIAMAFILIAELNTIAPIISNFFLASYALI 582
>gi|110224458 solute carrier family 12, member 6 isoform e [Homo
sapiens]
Length = 1135
Score = 40.4 bits (93), Expect = 0.005
Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 27/208 (12%)
Query: 255 VLSGAATCFYAFVGFDCIATTG--------EEVKNPQKAIPVGIVASLLICFIAYFGVSA 306
VL T F VG + TG ++K+ QK+IP+G + ++L Y
Sbjct: 462 VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS--- 518
Query: 307 ALTLMMPYFCLDN---NSPLPDAFK------HVGWEGAKYAVAVGSLCALSASLLGSMFP 357
+++ C++ DA K + W + + + +GS + + L S+
Sbjct: 519 --NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWP-SPWVIVIGSFFSTCGAGLQSLTG 575
Query: 358 MPRVIYAMAEDGLL-FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT 416
PR++ A+A+D ++ F + + P A L + A+A + + L + ++S+
Sbjct: 576 APRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 635
Query: 417 LLAYSLV-AACVL--VLRYQPEQPNLVY 441
L+ Y V AC L +LR +P Y
Sbjct: 636 LMCYLFVNLACALQTLLRTPNWRPRFRY 663
>gi|110224456 solute carrier family 12, member 6 isoform d [Homo
sapiens]
Length = 1141
Score = 40.4 bits (93), Expect = 0.005
Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 27/208 (12%)
Query: 255 VLSGAATCFYAFVGFDCIATTG--------EEVKNPQKAIPVGIVASLLICFIAYFGVSA 306
VL T F VG + TG ++K+ QK+IP+G + ++L Y
Sbjct: 468 VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS--- 524
Query: 307 ALTLMMPYFCLDN---NSPLPDAFK------HVGWEGAKYAVAVGSLCALSASLLGSMFP 357
+++ C++ DA K + W + + + +GS + + L S+
Sbjct: 525 --NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWP-SPWVIVIGSFFSTCGAGLQSLTG 581
Query: 358 MPRVIYAMAEDGLL-FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT 416
PR++ A+A+D ++ F + + P A L + A+A + + L + ++S+
Sbjct: 582 APRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 641
Query: 417 LLAYSLV-AACVL--VLRYQPEQPNLVY 441
L+ Y V AC L +LR +P Y
Sbjct: 642 LMCYLFVNLACALQTLLRTPNWRPRFRY 669
>gi|110224454 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 40.4 bits (93), Expect = 0.005
Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 27/208 (12%)
Query: 255 VLSGAATCFYAFVGFDCIATTG--------EEVKNPQKAIPVGIVASLLICFIAYFGVSA 306
VL T F VG + TG ++K+ QK+IP+G + ++L Y
Sbjct: 418 VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS--- 474
Query: 307 ALTLMMPYFCLDN---NSPLPDAFK------HVGWEGAKYAVAVGSLCALSASLLGSMFP 357
+++ C++ DA K + W + + + +GS + + L S+
Sbjct: 475 --NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWP-SPWVIVIGSFFSTCGAGLQSLTG 531
Query: 358 MPRVIYAMAEDGLL-FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT 416
PR++ A+A+D ++ F + + P A L + A+A + + L + ++S+
Sbjct: 532 APRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 591
Query: 417 LLAYSLV-AACVL--VLRYQPEQPNLVY 441
L+ Y V AC L +LR +P Y
Sbjct: 592 LMCYLFVNLACALQTLLRTPNWRPRFRY 619
>gi|110224452 solute carrier family 12, member 6 isoform c [Homo
sapiens]
Length = 1091
Score = 40.4 bits (93), Expect = 0.005
Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 27/208 (12%)
Query: 255 VLSGAATCFYAFVGFDCIATTG--------EEVKNPQKAIPVGIVASLLICFIAYFGVSA 306
VL T F VG + TG ++K+ QK+IP+G + ++L Y
Sbjct: 418 VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS--- 474
Query: 307 ALTLMMPYFCLDN---NSPLPDAFK------HVGWEGAKYAVAVGSLCALSASLLGSMFP 357
+++ C++ DA K + W + + + +GS + + L S+
Sbjct: 475 --NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWP-SPWVIVIGSFFSTCGAGLQSLTG 531
Query: 358 MPRVIYAMAEDGLL-FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT 416
PR++ A+A+D ++ F + + P A L + A+A + + L + ++S+
Sbjct: 532 APRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 591
Query: 417 LLAYSLV-AACVL--VLRYQPEQPNLVY 441
L+ Y V AC L +LR +P Y
Sbjct: 592 LMCYLFVNLACALQTLLRTPNWRPRFRY 619
>gi|4826780 solute carrier family 12, member 6 isoform b [Homo
sapiens]
Length = 1099
Score = 40.4 bits (93), Expect = 0.005
Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 27/208 (12%)
Query: 255 VLSGAATCFYAFVGFDCIATTG--------EEVKNPQKAIPVGIVASLLICFIAYFGVSA 306
VL T F VG + TG ++K+ QK+IP+G + ++L Y
Sbjct: 426 VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS--- 482
Query: 307 ALTLMMPYFCLDN---NSPLPDAFK------HVGWEGAKYAVAVGSLCALSASLLGSMFP 357
+++ C++ DA K + W + + + +GS + + L S+
Sbjct: 483 --NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWP-SPWVIVIGSFFSTCGAGLQSLTG 539
Query: 358 MPRVIYAMAEDGLL-FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT 416
PR++ A+A+D ++ F + + P A L + A+A + + L + ++S+
Sbjct: 540 APRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 599
Query: 417 LLAYSLV-AACVL--VLRYQPEQPNLVY 441
L+ Y V AC L +LR +P Y
Sbjct: 600 LMCYLFVNLACALQTLLRTPNWRPRFRY 627
>gi|110224449 solute carrier family 12, member 6 isoform a [Homo
sapiens]
Length = 1150
Score = 40.4 bits (93), Expect = 0.005
Identities = 48/208 (23%), Positives = 89/208 (42%), Gaps = 27/208 (12%)
Query: 255 VLSGAATCFYAFVGFDCIATTG--------EEVKNPQKAIPVGIVASLLICFIAYFGVSA 306
VL T F VG + TG ++K+ QK+IP+G + ++L Y
Sbjct: 477 VLVDITTSFTLLVGIFFPSVTGIMAGSNRSGDLKDAQKSIPIGTILAILTTSFVYLS--- 533
Query: 307 ALTLMMPYFCLDN---NSPLPDAFK------HVGWEGAKYAVAVGSLCALSASLLGSMFP 357
+++ C++ DA K + W + + + +GS + + L S+
Sbjct: 534 --NVVLFGACIEGVVLRDKFGDAVKGNLVVGTLSWP-SPWVIVIGSFFSTCGAGLQSLTG 590
Query: 358 MPRVIYAMAEDGLL-FKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGT 416
PR++ A+A+D ++ F + + P A L + A+A + + L + ++S+
Sbjct: 591 APRLLQAIAKDNIIPFLRVFGHSKANGEPTWALLLTAAIAELGILIASLDLVAPILSMFF 650
Query: 417 LLAYSLV-AACVL--VLRYQPEQPNLVY 441
L+ Y V AC L +LR +P Y
Sbjct: 651 LMCYLFVNLACALQTLLRTPNWRPRFRY 678
>gi|4506975 solute carrier family 12 (sodium/potassium/chloride
transporters), member 2 [Homo sapiens]
Length = 1212
Score = 38.5 bits (88), Expect = 0.019
Identities = 57/302 (18%), Positives = 114/302 (37%), Gaps = 67/302 (22%)
Query: 166 IFAVIIILILTGLLTLGVKESAMVNKIFTCINVLVLGFIMVSGFVKGSVKN--------W 217
I I ++IL G+ G++ A + I +L +G ++ F+ K
Sbjct: 411 IIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKS 470
Query: 218 QLTEEDFGNTSGRLCLNNDTKEGKPGVGGFMPF--GFSGVLSGAATCFYAFVGFDCIATT 275
++ E+FG D +E + F F +G+L+GA
Sbjct: 471 EIFNENFGP---------DFREEETFFSVFAIFFPAATGILAGA--------------NI 507
Query: 276 GEEVKNPQKAIPVGIVASLLICFIAYFGV----------------------------SAA 307
++ +PQ AIP G + ++LI + Y G+ SAA
Sbjct: 508 SGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAA 567
Query: 308 LTLMMPYFCLDNNS---PLPDAFKHVGW-EGAKYAVAVGSLCALSASLLGSMFPMPRVIY 363
L + +++ L + F+ + G ++ G A +S L S+ P++
Sbjct: 568 CKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQ 627
Query: 364 AMAEDGL--LFKFLANVNDRTKTPIIATLASGAVAAVMAFLFDLKDLVDLMSIGTLLAYS 421
A+ +D + F+ A + P+ + + +A + +L + ++S L +Y+
Sbjct: 628 ALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYA 687
Query: 422 LV 423
L+
Sbjct: 688 LI 689
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,833,345
Number of Sequences: 37866
Number of extensions: 911646
Number of successful extensions: 2592
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 2477
Number of HSP's gapped (non-prelim): 70
length of query: 629
length of database: 18,247,518
effective HSP length: 108
effective length of query: 521
effective length of database: 14,157,990
effective search space: 7376312790
effective search space used: 7376312790
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.