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Search of human proteins with 4506919
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
(502 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 1052 0.0
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 99 9e-21
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 99 9e-21
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 99 9e-21
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 99 9e-21
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 97 4e-20
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 80 6e-15
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 80 6e-15
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 77 3e-14
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 77 3e-14
gi|59797060 arylsulfatase family, member I [Homo sapiens] 74 2e-13
gi|39930577 arylsulfatase K [Homo sapiens] 69 1e-11
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 65 1e-10
gi|58743319 arylsulfatase family, member H [Homo sapiens] 64 2e-10
gi|45430057 Arylsulfatase G [Homo sapiens] 62 9e-10
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 62 2e-09
gi|109389362 arylsulfatase J [Homo sapiens] 62 2e-09
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 62 2e-09
gi|31742482 arylsulfatase F precursor [Homo sapiens] 60 4e-09
gi|157266309 arylsulfatase E precursor [Homo sapiens] 60 4e-09
gi|189571643 sulfatase 1 [Homo sapiens] 57 5e-08
gi|189571641 sulfatase 1 [Homo sapiens] 57 5e-08
gi|189571638 sulfatase 1 [Homo sapiens] 57 5e-08
gi|189571636 sulfatase 1 [Homo sapiens] 57 5e-08
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 54 3e-07
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 53 7e-07
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 52 1e-06
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 52 1e-06
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 52 1e-06
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 49 1e-05
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 1052 bits (2720), Expect = 0.0
Identities = 502/502 (100%), Positives = 502/502 (100%)
Query: 1 MSCPVPACCALLLVLGLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLF 60
MSCPVPACCALLLVLGLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLF
Sbjct: 1 MSCPVPACCALLLVLGLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLF 60
Query: 61 RNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGI 120
RNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGI
Sbjct: 61 RNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPLLLSQAGVRTGI 120
Query: 121 IGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDP 180
IGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDP
Sbjct: 121 IGKKHVGPETVYPFDFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDP 180
Query: 181 HRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQY 240
HRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQY
Sbjct: 181 HRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQY 240
Query: 241 TTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPE 300
TTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPE
Sbjct: 241 TTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWPGTAEPLLVSSPE 300
Query: 301 HPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWAT 360
HPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWAT
Sbjct: 301 HPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWAT 360
Query: 361 VFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQP 420
VFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQP
Sbjct: 361 VFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQP 420
Query: 421 TGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWV 480
TGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWV
Sbjct: 421 TGWYKDLRHYYYRARWELYDRSRDPHETQNLATDPRFAQLLEMLRDQLAKWQWETHDPWV 480
Query: 481 CAPDGVLEEKLSPQCQPLHNEL 502
CAPDGVLEEKLSPQCQPLHNEL
Sbjct: 481 CAPDGVLEEKLSPQCQPLHNEL 502
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 99.0 bits (245), Expect = 9e-21
Identities = 146/569 (25%), Positives = 203/569 (35%), Gaps = 154/569 (27%)
Query: 6 PACCALLLVLGLCRARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAF 64
P L L GL ARP N +L+ ADD G+ + G Y + + TP+LD LA L F + +
Sbjct: 4 PRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63
Query: 65 TSVSSCSPSRASLLTGLPQHQNGMY-GLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGK 123
VS C+PSRA+LLTG + GMY G+ + ++ +L+ G TG+ GK
Sbjct: 64 VPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123
Query: 124 KH--VGPETVYP---------FDFAYTEENGSVLQV-------------GRNITRIKLLV 159
H VGPE + Y+ + G + + + I LL
Sbjct: 124 WHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLA 183
Query: 160 RKFLQTQ------------------------DDRPFFLYVAFHDPHRCGHSQPQYG--TF 193
++ Q DRPFFLY A H H PQ+ +F
Sbjct: 184 NLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTH-----YPQFSGQSF 238
Query: 194 CEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLV 253
E+ G G G ++ +D VG +
Sbjct: 239 AERSGRGPFG-------------------------------------DSLMELDAAVGTL 261
Query: 254 LQELRDAGVLNDTLVIFTSDNGIP------------FPSGRTNLYWPGTAEPLLVSSPEH 301
+ + D G+L +TLVIFT+DNG G+ Y G EP L P H
Sbjct: 262 MTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGH 321
Query: 302 PKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATV 361
V+ S LDL PT+ P P+ + L G L P L +
Sbjct: 322 IA--PGVTHELASSLDLLPTLAALAGAPLPN--------VTLDGFDLSPLL--------L 363
Query: 362 FGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRT---TAG 418
+S + YP + R V +K F + T + + TA
Sbjct: 364 GTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAH 423
Query: 419 QPTGWYKDLRHYYYRARWELYDRSRDPHETQNL-----ATDPRFAQLLEMLRDQLAKWQW 473
+P LYD S+DP E NL P Q L+ L QL K Q
Sbjct: 424 EPP---------------LLYDLSKDPGENYNLLGGVAGATPEVLQALKQL--QLLKAQL 466
Query: 474 E---THDPWVCA--PDGVLEEKLSPQCQP 497
+ T P A D L+ P C P
Sbjct: 467 DAAVTFGPSQVARGEDPALQICCHPGCTP 495
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 99.0 bits (245), Expect = 9e-21
Identities = 146/569 (25%), Positives = 203/569 (35%), Gaps = 154/569 (27%)
Query: 6 PACCALLLVLGLCRARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAF 64
P L L GL ARP N +L+ ADD G+ + G Y + + TP+LD LA L F + +
Sbjct: 4 PRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63
Query: 65 TSVSSCSPSRASLLTGLPQHQNGMY-GLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGK 123
VS C+PSRA+LLTG + GMY G+ + ++ +L+ G TG+ GK
Sbjct: 64 VPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123
Query: 124 KH--VGPETVYP---------FDFAYTEENGSVLQV-------------GRNITRIKLLV 159
H VGPE + Y+ + G + + + I LL
Sbjct: 124 WHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLA 183
Query: 160 RKFLQTQ------------------------DDRPFFLYVAFHDPHRCGHSQPQYG--TF 193
++ Q DRPFFLY A H H PQ+ +F
Sbjct: 184 NLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTH-----YPQFSGQSF 238
Query: 194 CEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLV 253
E+ G G G ++ +D VG +
Sbjct: 239 AERSGRGPFG-------------------------------------DSLMELDAAVGTL 261
Query: 254 LQELRDAGVLNDTLVIFTSDNGIP------------FPSGRTNLYWPGTAEPLLVSSPEH 301
+ + D G+L +TLVIFT+DNG G+ Y G EP L P H
Sbjct: 262 MTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGH 321
Query: 302 PKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATV 361
V+ S LDL PT+ P P+ + L G L P L +
Sbjct: 322 IA--PGVTHELASSLDLLPTLAALAGAPLPN--------VTLDGFDLSPLL--------L 363
Query: 362 FGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRT---TAG 418
+S + YP + R V +K F + T + + TA
Sbjct: 364 GTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAH 423
Query: 419 QPTGWYKDLRHYYYRARWELYDRSRDPHETQNL-----ATDPRFAQLLEMLRDQLAKWQW 473
+P LYD S+DP E NL P Q L+ L QL K Q
Sbjct: 424 EPP---------------LLYDLSKDPGENYNLLGGVAGATPEVLQALKQL--QLLKAQL 466
Query: 474 E---THDPWVCA--PDGVLEEKLSPQCQP 497
+ T P A D L+ P C P
Sbjct: 467 DAAVTFGPSQVARGEDPALQICCHPGCTP 495
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 99.0 bits (245), Expect = 9e-21
Identities = 146/569 (25%), Positives = 203/569 (35%), Gaps = 154/569 (27%)
Query: 6 PACCALLLVLGLCRARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAF 64
P L L GL ARP N +L+ ADD G+ + G Y + + TP+LD LA L F + +
Sbjct: 4 PRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63
Query: 65 TSVSSCSPSRASLLTGLPQHQNGMY-GLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGK 123
VS C+PSRA+LLTG + GMY G+ + ++ +L+ G TG+ GK
Sbjct: 64 VPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123
Query: 124 KH--VGPETVYP---------FDFAYTEENGSVLQV-------------GRNITRIKLLV 159
H VGPE + Y+ + G + + + I LL
Sbjct: 124 WHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLA 183
Query: 160 RKFLQTQ------------------------DDRPFFLYVAFHDPHRCGHSQPQYG--TF 193
++ Q DRPFFLY A H H PQ+ +F
Sbjct: 184 NLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTH-----YPQFSGQSF 238
Query: 194 CEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLV 253
E+ G G G ++ +D VG +
Sbjct: 239 AERSGRGPFG-------------------------------------DSLMELDAAVGTL 261
Query: 254 LQELRDAGVLNDTLVIFTSDNGIP------------FPSGRTNLYWPGTAEPLLVSSPEH 301
+ + D G+L +TLVIFT+DNG G+ Y G EP L P H
Sbjct: 262 MTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGH 321
Query: 302 PKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATV 361
V+ S LDL PT+ P P+ + L G L P L +
Sbjct: 322 IA--PGVTHELASSLDLLPTLAALAGAPLPN--------VTLDGFDLSPLL--------L 363
Query: 362 FGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRT---TAG 418
+S + YP + R V +K F + T + + TA
Sbjct: 364 GTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAH 423
Query: 419 QPTGWYKDLRHYYYRARWELYDRSRDPHETQNL-----ATDPRFAQLLEMLRDQLAKWQW 473
+P LYD S+DP E NL P Q L+ L QL K Q
Sbjct: 424 EPP---------------LLYDLSKDPGENYNLLGGVAGATPEVLQALKQL--QLLKAQL 466
Query: 474 E---THDPWVCA--PDGVLEEKLSPQCQP 497
+ T P A D L+ P C P
Sbjct: 467 DAAVTFGPSQVARGEDPALQICCHPGCTP 495
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 99.0 bits (245), Expect = 9e-21
Identities = 146/569 (25%), Positives = 203/569 (35%), Gaps = 154/569 (27%)
Query: 6 PACCALLLVLGLCRARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAF 64
P L L GL ARP N +L+ ADD G+ + G Y + + TP+LD LA L F + +
Sbjct: 4 PRSLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63
Query: 65 TSVSSCSPSRASLLTGLPQHQNGMY-GLHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGK 123
VS C+PSRA+LLTG + GMY G+ + ++ +L+ G TG+ GK
Sbjct: 64 VPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGK 123
Query: 124 KH--VGPETVYP---------FDFAYTEENGSVLQV-------------GRNITRIKLLV 159
H VGPE + Y+ + G + + + I LL
Sbjct: 124 WHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLA 183
Query: 160 RKFLQTQ------------------------DDRPFFLYVAFHDPHRCGHSQPQYG--TF 193
++ Q DRPFFLY A H H PQ+ +F
Sbjct: 184 NLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASHHTH-----YPQFSGQSF 238
Query: 194 CEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLV 253
E+ G G G ++ +D VG +
Sbjct: 239 AERSGRGPFG-------------------------------------DSLMELDAAVGTL 261
Query: 254 LQELRDAGVLNDTLVIFTSDNGIP------------FPSGRTNLYWPGTAEPLLVSSPEH 301
+ + D G+L +TLVIFT+DNG G+ Y G EP L P H
Sbjct: 262 MTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGH 321
Query: 302 PKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATV 361
V+ S LDL PT+ P P+ + L G L P L +
Sbjct: 322 IA--PGVTHELASSLDLLPTLAALAGAPLPN--------VTLDGFDLSPLL--------L 363
Query: 362 FGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRT---TAG 418
+S + YP + R V +K F + T + + TA
Sbjct: 364 GTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAH 423
Query: 419 QPTGWYKDLRHYYYRARWELYDRSRDPHETQNL-----ATDPRFAQLLEMLRDQLAKWQW 473
+P LYD S+DP E NL P Q L+ L QL K Q
Sbjct: 424 EPP---------------LLYDLSKDPGENYNLLGGVAGATPEVLQALKQL--QLLKAQL 466
Query: 474 E---THDPWVCA--PDGVLEEKLSPQCQP 497
+ T P A D L+ P C P
Sbjct: 467 DAAVTFGPSQVARGEDPALQICCHPGCTP 495
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 96.7 bits (239), Expect = 4e-20
Identities = 115/394 (29%), Positives = 156/394 (39%), Gaps = 112/394 (28%)
Query: 21 RPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLT 79
+P N LLLL DD G+ + G Y + TP+LD +A LLF N +++ CSPSRA+LLT
Sbjct: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88
Query: 80 GLPQHQNGMYGLHQDVHHFNSF----------DKVRSLPLLLSQAGVRTGIIGKKHVGPE 129
G +NG Y + H N++ D + LP LL +AG + I+GK H+G
Sbjct: 89 GRLPIRNGFY--TTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR 146
Query: 130 TVY-------------------PFD----------------FAYTEENGSVLQVGR-NIT 153
+ P+D Y EE L+ G N+T
Sbjct: 147 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT 206
Query: 154 RIKLL-VRKFLQTQ-DDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWT 211
+I L F++ Q PFFLY A H P Y + K G S GR D
Sbjct: 207 QIYLQEALDFIKRQARHHPFFLYWAVDATH-----APVYAS---KPFLGTSQRGRYGD-- 256
Query: 212 PQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFT 271
V +D +G +L+ L+D V ++T V FT
Sbjct: 257 ------------------------------AVREIDDSIGKILELLQDLHVADNTFVFFT 286
Query: 272 SDNGI-------------PFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDL 318
SDNG PF G+ + G EP L P H GQVS S++DL
Sbjct: 287 SDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTA-GQVSHQLGSIMDL 345
Query: 319 TPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPAL 352
T L + PS + G +LLP L
Sbjct: 346 FTTSLALAGLTPPSDRA-------IDGLNLLPTL 372
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 79.7 bits (195), Expect = 6e-15
Identities = 88/335 (26%), Positives = 133/335 (39%), Gaps = 92/335 (27%)
Query: 5 VPACCALLLVL-------GLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRS 57
+P LLL+L G +RP + + LLADD G+ ++ S I TPHLDALA
Sbjct: 20 LPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGG 79
Query: 58 LLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFN----SFDKVRSLPLLLSQ 113
+L N +T C+PSR+ LLTG Q + G+ HQ + D+ + LP LL +
Sbjct: 80 VLLDNYYTQ-PLCTPSRSQLLTGRYQIRTGLQ--HQIIWPCQPSCVPLDE-KLLPQLLKE 135
Query: 114 AGVRTGIIGKKHVGP------------ETVYPF----DFAYTEENGSVLQVGRNITR--- 154
AG T ++GK H+G +T + + + Y+ E +++ N+TR
Sbjct: 136 AGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLID-ALNVTRCAL 194
Query: 155 ---------------------IKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTF 193
K + ++P FLY+A H
Sbjct: 195 DFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVH------------ 242
Query: 194 CEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLV 253
+PL V Y P + V MD+ VG V
Sbjct: 243 ----------------------EPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNV 280
Query: 254 LQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWP 288
L+ +G+ N+T+ IF++DNG +G N WP
Sbjct: 281 TAALKSSGLWNNTVFIFSTDNGGQTLAGGNN--WP 313
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 79.7 bits (195), Expect = 6e-15
Identities = 88/335 (26%), Positives = 133/335 (39%), Gaps = 92/335 (27%)
Query: 5 VPACCALLLVL-------GLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRS 57
+P LLL+L G +RP + + LLADD G+ ++ S I TPHLDALA
Sbjct: 20 LPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGG 79
Query: 58 LLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFN----SFDKVRSLPLLLSQ 113
+L N +T C+PSR+ LLTG Q + G+ HQ + D+ + LP LL +
Sbjct: 80 VLLDNYYTQ-PLCTPSRSQLLTGRYQIRTGLQ--HQIIWPCQPSCVPLDE-KLLPQLLKE 135
Query: 114 AGVRTGIIGKKHVGP------------ETVYPF----DFAYTEENGSVLQVGRNITR--- 154
AG T ++GK H+G +T + + + Y+ E +++ N+TR
Sbjct: 136 AGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLID-ALNVTRCAL 194
Query: 155 ---------------------IKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTF 193
K + ++P FLY+A H
Sbjct: 195 DFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVH------------ 242
Query: 194 CEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLV 253
+PL V Y P + V MD+ VG V
Sbjct: 243 ----------------------EPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNV 280
Query: 254 LQELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWP 288
L+ +G+ N+T+ IF++DNG +G N WP
Sbjct: 281 TAALKSSGLWNNTVFIFSTDNGGQTLAGGNN--WP 313
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 77.4 bits (189), Expect = 3e-14
Identities = 80/306 (26%), Positives = 120/306 (39%), Gaps = 61/306 (19%)
Query: 24 NALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQ 83
N LL++ DD G Y + + +P++D LA SLLF+NAF + C+PSR S LTG
Sbjct: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
Query: 84 HQNGMYGLHQDVHHFNSFDKVR-----SLPLLLSQAGVRTGIIGKK-HVGPETVYPFDFA 137
+Y FNS+ +V ++P + G T +GK H G + + D
Sbjct: 98 DTTRLY-------DFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSP 150
Query: 138 YT------------EENG------------------SVLQVGRNITRIKLLVRKFLQTQD 167
Y+ EN VL V K + +Q +
Sbjct: 151 YSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLE 210
Query: 168 D-----RPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQ-AYDP---- 217
PFFL V +H PH ++ + +PD P AY+P
Sbjct: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270
Query: 218 --------LDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVI 269
L++ VPY R + + +V +D VG +L L D + N T++
Sbjct: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330
Query: 270 FTSDNG 275
FTSD+G
Sbjct: 331 FTSDHG 336
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 77.4 bits (189), Expect = 3e-14
Identities = 80/306 (26%), Positives = 120/306 (39%), Gaps = 61/306 (19%)
Query: 24 NALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQ 83
N LL++ DD G Y + + +P++D LA SLLF+NAF + C+PSR S LTG
Sbjct: 38 NVLLIIVDDLRPSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRP 97
Query: 84 HQNGMYGLHQDVHHFNSFDKVR-----SLPLLLSQAGVRTGIIGKK-HVGPETVYPFDFA 137
+Y FNS+ +V ++P + G T +GK H G + + D
Sbjct: 98 DTTRLY-------DFNSYWRVHAGNFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSP 150
Query: 138 YT------------EENG------------------SVLQVGRNITRIKLLVRKFLQTQD 167
Y+ EN VL V K + +Q +
Sbjct: 151 YSWSFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQSTEQAIQLLE 210
Query: 168 D-----RPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQ-AYDP---- 217
PFFL V +H PH ++ + +PD P AY+P
Sbjct: 211 KMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDI 270
Query: 218 --------LDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVI 269
L++ VPY R + + +V +D VG +L L D + N T++
Sbjct: 271 RQREDVQALNISVPYGPIPVDFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIA 330
Query: 270 FTSDNG 275
FTSD+G
Sbjct: 331 FTSDHG 336
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 74.3 bits (181), Expect = 2e-13
Identities = 92/347 (26%), Positives = 131/347 (37%), Gaps = 80/347 (23%)
Query: 21 RPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTG 80
+P + + +L DD G+ Y+ S I TP LD LA + + N + C+PSR+ LLTG
Sbjct: 45 QPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQ-PICTPSRSQLLTG 103
Query: 81 LPQHQNGMYG--LHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVG------PETVY 132
Q G+ + + D+V +LP L +AG T ++GK H+G T
Sbjct: 104 RYQIHTGLQHSIIRPQQPNCLPLDQV-TLPQKLQEAGYSTHMVGKWHLGFYRKECLPTRR 162
Query: 133 PFDF----------AYTEEN-------GSVLQVGRNIT-------RIKLLVRK----FLQ 164
FD YT +N G L G N+ L ++
Sbjct: 163 GFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQYSTMLYAQRASHILAS 222
Query: 165 TQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPY 224
RP FLYVAF H S +Y GN
Sbjct: 223 HSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGN------------------------- 257
Query: 225 FVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTN 284
AR AA T MD+ V + L+ G N++++IF+SDNG SG +N
Sbjct: 258 ------VARRKYAAMVTC---MDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFSGGSN 308
Query: 285 --------LYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTIL 323
YW G L KR + S A + + D PT++
Sbjct: 309 WPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLV 355
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 68.6 bits (166), Expect = 1e-11
Identities = 96/380 (25%), Positives = 155/380 (40%), Gaps = 74/380 (19%)
Query: 20 ARPRNALLLLAD--DGG--FESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRA 75
A+ N +L+++D DG F G+ + P ++ + R F NA+T+ C PSRA
Sbjct: 29 AKAPNVVLVVSDSFDGRLTFHPGS---QVVKLPFINFMKTRGTSFLNAYTNSPICCPSRA 85
Query: 76 SLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPL-LLSQAGVRTGIIGK------KHVGP 128
++ +GL H L + ++F D + + ++ + G RT GK H
Sbjct: 86 AMWSGLFTH------LTESWNNFKGLDPNYTTWMDVMERHGYRTQKFGKLDYTSGHHSIS 139
Query: 129 ETVYPFD----FAYTEENGSVLQVGRNITRIKLLVRKFLQTQD------------DRPFF 172
V + F +E ++ + RN T+++++ R + T PF
Sbjct: 140 NRVEAWTRDVAFLLRQEGRPMVNLIRNRTKVRVMERDWQNTDKAVNWLRKEAINYTEPFV 199
Query: 173 LYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMG------------RIPDWTP-QAYDPLD 219
+Y+ + PH + P G E FG+ +IP W+P P+D
Sbjct: 200 IYLGLNLPH--PYPSPSSG---ENFGSSTFHTSLYWLEKVSHDAIKIPKWSPLSEMHPVD 254
Query: 220 VLVPYFVPNT-----PAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDN 274
Y T + A Y D +G ++ L +L T+VI++SD+
Sbjct: 255 YYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAMLGEIILALHQLDLLQKTIVIYSSDH 314
Query: 275 GIPFPSGR----TNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPY 330
G R ++Y PLL+ P K QVS VSL+D+ PT+LD IP
Sbjct: 315 GELAMEHRQFYKMSMYEASAHVPLLMMGP-GIKAGLQVSNV-VSLVDIYPTMLDIAGIPL 372
Query: 331 PSYAIFGSKTIHLTGRSLLP 350
P +L+G SLLP
Sbjct: 373 PQ---------NLSGYSLLP 383
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 65.1 bits (157), Expect = 1e-10
Identities = 108/401 (26%), Positives = 157/401 (39%), Gaps = 72/401 (17%)
Query: 5 VPAC--CALLLVLGLCRA--------RPRNALLLLADDGGFESGAYNNSAIATPHLDALA 54
+P+C LLLVLG C R N +LLL DD + +
Sbjct: 19 LPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDD---QDEVLGGMTPLKKTKALIG 75
Query: 55 RRSLLFRNAFTSVSSCSPSRASLLTG-LPQHQNGMYGLHQDVHHFNSFDKVR---SLPLL 110
+ F +A+ + C PSRAS+LTG P + + + + S+ K++ + P +
Sbjct: 76 EMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAI 135
Query: 111 L-SQAGVRTGIIGK-------------KHV--GPETVYPFD-----FAYTEE-NGSVLQV 148
L S G +T GK +HV G Y + + YT NG +
Sbjct: 136 LRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKH 195
Query: 149 GRN-----ITRIKLLVR-KFLQTQDD-RPFFLYVAFHDPHRCGHSQPQYG-TFCEKFGNG 200
G N +T + V FL + + PFF+ +A PH + PQY F F
Sbjct: 196 GENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPR 255
Query: 201 ESGM---GRIPDWT-PQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQE 256
G W QA P+ F+ N R + T+ +D V +++
Sbjct: 256 NKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKR------WQTLLSVDDLVEKLVKR 309
Query: 257 LRDAGVLNDTLVIFTSDNG-----IPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEA 311
L G LN+T + +TSDNG P + LY PLLV P + Q S+
Sbjct: 310 LEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGP--GIKPNQTSKM 367
Query: 312 YVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPAL 352
V+ +DL PTILD A + + G SLLP L
Sbjct: 368 LVANIDLGPTILD--------IAGYDLNKTQMDGMSLLPIL 400
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 64.3 bits (155), Expect = 2e-10
Identities = 44/127 (34%), Positives = 62/127 (48%), Gaps = 9/127 (7%)
Query: 20 ARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLL 78
ARP N +LL+ADD G + Y N++++TP++D LA + + S C+PSRA+ L
Sbjct: 5 ARP-NIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFL 63
Query: 79 TGLPQHQNGMYGLHQDVHHFNSFDKVRSLPL-------LLSQAGVRTGIIGKKHVGPETV 131
TG ++GM + F LP LL G RTG+IGK H+G
Sbjct: 64 TGRYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCA 123
Query: 132 YPFDFAY 138
D Y
Sbjct: 124 SRNDHCY 130
Score = 34.7 bits (78), Expect = 0.21
Identities = 43/148 (29%), Positives = 54/148 (36%), Gaps = 30/148 (20%)
Query: 243 VGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFP--------SGRTNLYWPGTAEPL 294
V MD VG +L L + N TLV FTSDNG G +Y G
Sbjct: 293 VEEMDWMVGKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGG 352
Query: 295 LVSSPEHPK--RWGQVSEA------YVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGR 346
P RW V EA SL+D+ PT + Y I + + G+
Sbjct: 353 WEGGIRVPGIFRWPSVLEAGRVINEPTSLMDIYPT------LSYIGGGILSQDRV-IDGQ 405
Query: 347 SLLPALEAEPLWATVFGSQSHHEVTMSY 374
+L+P LE S S HE Y
Sbjct: 406 NLMPLLEGR-------ASHSDHEFLFHY 426
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 62.4 bits (150), Expect = 9e-10
Identities = 48/131 (36%), Positives = 65/131 (49%), Gaps = 15/131 (11%)
Query: 14 VLGLCRARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSP 72
+ G R + N +++LADD G+ + GA T +LD +A + F + + S+CSP
Sbjct: 27 ISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSP 86
Query: 73 SRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPL-------LLSQAGVRTGIIGKKH 125
SRASLLT G GL V + V LPL +L QAG TGIIGK H
Sbjct: 87 SRASLLT-------GRLGLRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWH 139
Query: 126 VGPETVYPFDF 136
+G Y +F
Sbjct: 140 LGHHGSYHPNF 150
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 61.6 bits (148), Expect = 2e-09
Identities = 42/135 (31%), Positives = 63/135 (46%), Gaps = 12/135 (8%)
Query: 5 VPACCALLLVLGLCRARPRNA-----LLLLADD-GGFESGAYNNSAIATPHLDALARRSL 58
+P L L+L C + NA LL++ADD G + G Y N+ + TP++D LA +
Sbjct: 18 LPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGV 77
Query: 59 LFRNAFTSVSSCSPSRASLLTGLPQHQNGM------YGLHQDVHHFNSFDKVRSLPLLLS 112
+ C+PSRA+ LTG ++GM L + + + +L
Sbjct: 78 RLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQ 137
Query: 113 QAGVRTGIIGKKHVG 127
Q G TG+IGK H G
Sbjct: 138 QHGYATGLIGKWHQG 152
Score = 35.0 bits (79), Expect = 0.16
Identities = 58/265 (21%), Positives = 89/265 (33%), Gaps = 61/265 (23%)
Query: 218 LDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNG-- 275
L V +P + ++ V MD +G VL + D G+ N T FTSD+G
Sbjct: 301 LHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGH 360
Query: 276 IPFPSGRTNL--------------------------YWPGTAEPLLVSSPEHPKRWGQVS 309
+ G + L +WPG G+V
Sbjct: 361 LEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPA------------GRVI 408
Query: 310 EAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHE 369
SL+D+ PT++ P + + G SL+P L+ ++S HE
Sbjct: 409 GEPTSLMDVFPTVVQLVGGEVPQDRV-------IDGHSLVPLLQGAE-------ARSAHE 454
Query: 370 VTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSPTFQDLLNRTTAGQPTGWYKDLRH 429
Y QH H H + + + Y +P F G+
Sbjct: 455 FLFHY---CGQHLHAARWHQKDSGSVWKVH---YTTPQFHPEGAGACYGRGVCPCSGEGV 508
Query: 430 YYYRARWELYDRSRDPHETQNLATD 454
++R L+D SRDP E + L D
Sbjct: 509 THHRPPL-LFDLSRDPSEARPLTPD 532
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 61.6 bits (148), Expect = 2e-09
Identities = 73/329 (22%), Positives = 115/329 (34%), Gaps = 53/329 (16%)
Query: 26 LLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQ 85
+ +LADD GF Y+ S I TP LD LA + N + C+PSR+ +TG Q
Sbjct: 79 IFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQ-PICTPSRSQFITGKYQIH 137
Query: 86 NGMYG--LHQDVHHFNSFDKVRSLPLLLSQAGVRTGIIGKKHVG--PETVYPFDFAYTEE 141
G+ + + D +LP L + G T ++GK H+G + P +
Sbjct: 138 TGLQHSIIRPTQPNCLPLDNA-TLPQKLKEVGYSTHMVGKWHLGFYRKECMPTRRGFDTF 196
Query: 142 NGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGE 201
GS+L G T K P CG+ + + NG
Sbjct: 197 FGSLLGSGDYYTHYKC--------------------DSPGMCGYDLYENDNAAWDYDNGI 236
Query: 202 SGMGRIPDWTPQ-------------------AYDPLDVLVPYFVPNTPAARADLAAQYTT 242
Q + PL YF +
Sbjct: 237 YSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAAM 296
Query: 243 VGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPSGRTN--------LYWPGTAEPL 294
+ +D+ + V L+ G N++++I++SDNG +G +N YW G +
Sbjct: 297 LSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLRGSKGTYWEGGIRAV 356
Query: 295 LVSSPEHPKRWGQVSEAYVSLLDLTPTIL 323
K G V + V + D PT++
Sbjct: 357 GFVHSPLLKNKGTVCKELVHITDWYPTLI 385
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 61.6 bits (148), Expect = 2e-09
Identities = 42/135 (31%), Positives = 63/135 (46%), Gaps = 12/135 (8%)
Query: 5 VPACCALLLVLGLCRARPRNA-----LLLLADD-GGFESGAYNNSAIATPHLDALARRSL 58
+P L L+L C + NA LL++ADD G + G Y N+ + TP++D LA +
Sbjct: 18 LPVLLFLCLLLKTCEPKTANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGV 77
Query: 59 LFRNAFTSVSSCSPSRASLLTGLPQHQNGM------YGLHQDVHHFNSFDKVRSLPLLLS 112
+ C+PSRA+ LTG ++GM L + + + +L
Sbjct: 78 RLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWNAGSGGLPENETTFARILQ 137
Query: 113 QAGVRTGIIGKKHVG 127
Q G TG+IGK H G
Sbjct: 138 QHGYATGLIGKWHQG 152
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 60.5 bits (145), Expect = 4e-09
Identities = 45/132 (34%), Positives = 63/132 (47%), Gaps = 17/132 (12%)
Query: 9 CALLLVLGLCRAR-----PRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRN 62
CALL C+A N +L++ DD G + G Y N + TPH+D LAR +
Sbjct: 14 CALL---NTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQ 70
Query: 63 AFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKVRSLPL-------LLSQAG 115
++ S CSPSR++ LTG ++GM + + LPL LL + G
Sbjct: 71 HISAASLCSPSRSAFLTGRYPIRSGMVS-SGNRRVIQNLAVPAGLPLNETTLAALLKKQG 129
Query: 116 VRTGIIGKKHVG 127
TG+IGK H G
Sbjct: 130 YSTGLIGKWHQG 141
Score = 37.0 bits (84), Expect = 0.042
Identities = 65/259 (25%), Positives = 96/259 (37%), Gaps = 60/259 (23%)
Query: 243 VGRMDQGVGLVLQELRDAGVLNDTLVIFTSD-----------------NGIPFPSGRTNL 285
V MD VG +L + D G+ N+TLV FTSD NGI + G+
Sbjct: 315 VEEMDSMVGKILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGI-YKGGKGMG 373
Query: 286 YWPGTAE-PLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLT 344
W G P +V P G++ + SL+D+ PT+ P + +
Sbjct: 374 GWEGGIRVPGIVRWPGKVPA-GRLIKEPTSLMDILPTVASVSGGSLPQDRV-------ID 425
Query: 345 GRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYV 404
GR L+P L+ S HE Y + V + + + YV
Sbjct: 426 GRDLMPLLQGNV-------RHSEHEFLFHY-----CGSYLHAVRWIPKDDSGSVWKAHYV 473
Query: 405 SPTFQ---------DLLNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNL--AT 453
+P FQ L R Q T Y L+D SRDP E+ L AT
Sbjct: 474 TPVFQPPASGGCYVTSLCRCFGEQVT----------YHNPPLLFDLSRDPSESTPLTPAT 523
Query: 454 DPRFAQLLEMLRDQLAKWQ 472
+P +++ + + L + Q
Sbjct: 524 EPLHDFVIKKVANALKEHQ 542
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 60.5 bits (145), Expect = 4e-09
Identities = 46/136 (33%), Positives = 69/136 (50%), Gaps = 14/136 (10%)
Query: 5 VPACCALLLVLG------LCRARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRS 57
+PA A+LL L + +RP N LLL+ADD G + G Y N+ + TP++D LA
Sbjct: 15 LPAMLAVLLSLAPSASSDISASRP-NILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDG 73
Query: 58 LLFRNAFTSVSSCSPSRASLLTGLPQHQNGM-----YGLHQDVHHFNSF-DKVRSLPLLL 111
+ ++ S C+PSRA+ LTG ++GM Y + Q + +L
Sbjct: 74 VKLTQHISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKIL 133
Query: 112 SQAGVRTGIIGKKHVG 127
+ G TG+IGK H+G
Sbjct: 134 KEKGYATGLIGKWHLG 149
Score = 41.2 bits (95), Expect = 0.002
Identities = 69/251 (27%), Positives = 97/251 (38%), Gaps = 47/251 (18%)
Query: 243 VGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIPFPS--------GRTNLYWPGTAEPL 294
V MD VG +L L G+ N TL+ FTSD+G + G +Y G
Sbjct: 323 VEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGG 382
Query: 295 LVSSPEHPK--RW------GQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGR 346
P RW G+V SL+D+ PT++ P + + G+
Sbjct: 383 WEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRV-------IDGQ 435
Query: 347 SLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYVSP 406
LLP L S HE M Y R + H H + + + +V+P
Sbjct: 436 DLLPLLLGT-------AQHSDHEFLMHYCERFL---HAARWHQRDRGTMWKV---HFVTP 482
Query: 407 TFQDLLNRTTAGQ---PTGWYKDLRHYYYRARWELYDRSRDPHETQNL--ATDPRFAQLL 461
FQ G+ P K + H L+D SRDP ET L A++P F Q++
Sbjct: 483 VFQPEGAGACYGRKVCPCFGEKVVHH----DPPLLFDLSRDPSETHILTPASEPVFYQVM 538
Query: 462 EMLRDQLAKWQ 472
E R Q A W+
Sbjct: 539 E--RVQQAVWE 547
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 56.6 bits (135), Expect = 5e-08
Identities = 92/412 (22%), Positives = 152/412 (36%), Gaps = 86/412 (20%)
Query: 7 ACCALLL-VLG------LC------RARPR----------NALLLLADDGGFESGAYNNS 43
+CCAL+L VLG LC R R R N +L+L DD E G+
Sbjct: 4 SCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQ-- 61
Query: 44 AIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVH--HFNSF 101
+ + F NAF + C PSR+S+LTG H + +Y +++ + +
Sbjct: 62 -VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
Query: 102 DKVRSLPLLLSQAGVRTGIIGK-------KHVGP-----------ETVYPF--------- 134
+ R+ + L+ G RT GK ++ P Y +
Sbjct: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 135 --DFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGT 192
F Y ++ + L +I K+ R + RP + ++ PH S PQ
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMY----PHRPVMMVISHAAPHGPEDSAPQ--- 233
Query: 193 FCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPA----ARADLAAQYTTVGRMDQ 248
F + + N + ++ P ++ Y P P + T+ +D
Sbjct: 234 FSKLYPNASQHITPSYNYAPNM--DKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDD 291
Query: 249 GVGLVLQELRDAGVLNDTLVIFTSDNG-----IPFPSGRTNLYWPGTAEPLLVSSPEHPK 303
V + L + G L +T +I+T+D+G G++ Y P + P
Sbjct: 292 SVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEP 351
Query: 304 RWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAE 355
G + V +DL PTILD + P + G+S+L L+ E
Sbjct: 352 --GSIVPQIVLNIDLAPTILDIAGLDTPP---------DVDGKSVLKLLDPE 392
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 56.6 bits (135), Expect = 5e-08
Identities = 92/412 (22%), Positives = 152/412 (36%), Gaps = 86/412 (20%)
Query: 7 ACCALLL-VLG------LC------RARPR----------NALLLLADDGGFESGAYNNS 43
+CCAL+L VLG LC R R R N +L+L DD E G+
Sbjct: 4 SCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQ-- 61
Query: 44 AIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVH--HFNSF 101
+ + F NAF + C PSR+S+LTG H + +Y +++ + +
Sbjct: 62 -VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
Query: 102 DKVRSLPLLLSQAGVRTGIIGK-------KHVGP-----------ETVYPF--------- 134
+ R+ + L+ G RT GK ++ P Y +
Sbjct: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 135 --DFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGT 192
F Y ++ + L +I K+ R + RP + ++ PH S PQ
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMY----PHRPVMMVISHAAPHGPEDSAPQ--- 233
Query: 193 FCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPA----ARADLAAQYTTVGRMDQ 248
F + + N + ++ P ++ Y P P + T+ +D
Sbjct: 234 FSKLYPNASQHITPSYNYAPNM--DKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDD 291
Query: 249 GVGLVLQELRDAGVLNDTLVIFTSDNG-----IPFPSGRTNLYWPGTAEPLLVSSPEHPK 303
V + L + G L +T +I+T+D+G G++ Y P + P
Sbjct: 292 SVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEP 351
Query: 304 RWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAE 355
G + V +DL PTILD + P + G+S+L L+ E
Sbjct: 352 --GSIVPQIVLNIDLAPTILDIAGLDTPP---------DVDGKSVLKLLDPE 392
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 56.6 bits (135), Expect = 5e-08
Identities = 92/412 (22%), Positives = 152/412 (36%), Gaps = 86/412 (20%)
Query: 7 ACCALLL-VLG------LC------RARPR----------NALLLLADDGGFESGAYNNS 43
+CCAL+L VLG LC R R R N +L+L DD E G+
Sbjct: 4 SCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQ-- 61
Query: 44 AIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVH--HFNSF 101
+ + F NAF + C PSR+S+LTG H + +Y +++ + +
Sbjct: 62 -VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
Query: 102 DKVRSLPLLLSQAGVRTGIIGK-------KHVGP-----------ETVYPF--------- 134
+ R+ + L+ G RT GK ++ P Y +
Sbjct: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 135 --DFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGT 192
F Y ++ + L +I K+ R + RP + ++ PH S PQ
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMY----PHRPVMMVISHAAPHGPEDSAPQ--- 233
Query: 193 FCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPA----ARADLAAQYTTVGRMDQ 248
F + + N + ++ P ++ Y P P + T+ +D
Sbjct: 234 FSKLYPNASQHITPSYNYAPNM--DKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDD 291
Query: 249 GVGLVLQELRDAGVLNDTLVIFTSDNG-----IPFPSGRTNLYWPGTAEPLLVSSPEHPK 303
V + L + G L +T +I+T+D+G G++ Y P + P
Sbjct: 292 SVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEP 351
Query: 304 RWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAE 355
G + V +DL PTILD + P + G+S+L L+ E
Sbjct: 352 --GSIVPQIVLNIDLAPTILDIAGLDTPP---------DVDGKSVLKLLDPE 392
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 56.6 bits (135), Expect = 5e-08
Identities = 92/412 (22%), Positives = 152/412 (36%), Gaps = 86/412 (20%)
Query: 7 ACCALLL-VLG------LC------RARPR----------NALLLLADDGGFESGAYNNS 43
+CCAL+L VLG LC R R R N +L+L DD E G+
Sbjct: 4 SCCALVLAVLGTELLGSLCSTVRSPRFRGRIQQERKNIRPNIILVLTDDQDVELGSLQ-- 61
Query: 44 AIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVH--HFNSF 101
+ + F NAF + C PSR+S+LTG H + +Y +++ + +
Sbjct: 62 -VMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVHNHNVYTNNENCSSPSWQAM 120
Query: 102 DKVRSLPLLLSQAGVRTGIIGK-------KHVGP-----------ETVYPF--------- 134
+ R+ + L+ G RT GK ++ P Y +
Sbjct: 121 HEPRTFAVYLNNTGYRTAFFGKYLNEYNGSYIPPGWREWLGLIKNSRFYNYTVCRNGIKE 180
Query: 135 --DFAYTEENGSVLQVGRNITRIKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGT 192
F Y ++ + L +I K+ R + RP + ++ PH S PQ
Sbjct: 181 KHGFDYAKDYFTDLITNESINYFKMSKRMY----PHRPVMMVISHAAPHGPEDSAPQ--- 233
Query: 193 FCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPA----ARADLAAQYTTVGRMDQ 248
F + + N + ++ P ++ Y P P + T+ +D
Sbjct: 234 FSKLYPNASQHITPSYNYAPNM--DKHWIMQYTGPMLPIHMEFTNILQRKRLQTLMSVDD 291
Query: 249 GVGLVLQELRDAGVLNDTLVIFTSDNG-----IPFPSGRTNLYWPGTAEPLLVSSPEHPK 303
V + L + G L +T +I+T+D+G G++ Y P + P
Sbjct: 292 SVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKSMPYDFDIRVPFFIRGPSVEP 351
Query: 304 RWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPALEAE 355
G + V +DL PTILD + P + G+S+L L+ E
Sbjct: 352 --GSIVPQIVLNIDLAPTILDIAGLDTPP---------DVDGKSVLKLLDPE 392
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 54.3 bits (129), Expect = 3e-07
Identities = 90/359 (25%), Positives = 121/359 (33%), Gaps = 104/359 (28%)
Query: 166 QDDRPFFLYVAFHDPHRCGHSQPQYG--TFCEKFGNGESGMGRIPDWTPQAYDPLDVLVP 223
+ DRPFFLY A H H PQ+ +F E+ G G G
Sbjct: 130 RQDRPFFLYYASHHTH-----YPQFSGQSFAERSGRGPFG-------------------- 164
Query: 224 YFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNGIP------ 277
++ +D VG ++ + D G+L +TLVIFT+DNG
Sbjct: 165 -----------------DSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSR 207
Query: 278 ------FPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYP 331
G+ Y G EP L P H V+ S LDL PT+ P P
Sbjct: 208 GGCSGLLRCGKGTTYEGGVREPALAFWPGHIA--PGVTHELASSLDLLPTLAALAGAPLP 265
Query: 332 SYAIFGSKTIHLTGRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLN 391
+ + L G L P L + +S + YP + R V
Sbjct: 266 N--------VTLDGFDLSPLL--------LGTGKSPRQSLFFYPSYPDEVRGVFAVRTGK 309
Query: 392 FKMPFPIDQDFYVSPTFQDLLNRT---TAGQPTGWYKDLRHYYYRARWELYDRSRDPHET 448
+K F + T + + TA +P LYD S+DP E
Sbjct: 310 YKAHFFTQGSAHSDTTADPACHASSSLTAHEPP---------------LLYDLSKDPGEN 354
Query: 449 QNL-----ATDPRFAQLLEMLRDQLAKWQWE---THDPWVCA--PDGVLEEKLSPQCQP 497
NL P Q L+ L QL K Q + T P A D L+ P C P
Sbjct: 355 YNLLGGVAGATPEVLQALKQL--QLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTP 411
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 52.8 bits (125), Expect = 7e-07
Identities = 41/127 (32%), Positives = 62/127 (48%), Gaps = 10/127 (7%)
Query: 20 ARPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLL 78
+RP N +L++ADD G + G Y N I TP++D LA + + C+PSRA+ +
Sbjct: 25 SRP-NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFM 83
Query: 79 TGLPQHQNGMYGLHQ-DVHHFNS------FDKVRSLPLLLSQAGVRTGIIGKKHVGPETV 131
TG ++GM + V F + D++ LL Q G T +IGK H+G
Sbjct: 84 TGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQ-GYSTALIGKWHLGMSCH 142
Query: 132 YPFDFAY 138
DF +
Sbjct: 143 SKTDFCH 149
Score = 46.6 bits (109), Expect = 5e-05
Identities = 60/245 (24%), Positives = 101/245 (41%), Gaps = 45/245 (18%)
Query: 243 VGRMDQGVGLVLQELRDAGVLNDTLVIFTSD------------------NGIPFPSGRTN 284
V MD VG +L L + + NDTL+ FTSD NGI + G+ N
Sbjct: 312 VEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGI-YKGGKAN 370
Query: 285 LYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLT 344
+ G P ++ P + GQ + S +D+ PT+ P P I +
Sbjct: 371 NWEGGIRVPGILRWPRVIQA-GQKIDEPTSNMDIFPTVAKLAGAPLPEDRI-------ID 422
Query: 345 GRSLLPALEAEPLWATVFGSQSHHEVTMSYPMRSVQHRHFRLVHNLNFKMPFPIDQDFYV 404
GR L+P LE + +S HE Y + + ++ + I + F+
Sbjct: 423 GRDLMPLLEGK-------SQRSDHEFLFHYCNAYLNAVRWHPQNSTS------IWKAFFF 469
Query: 405 SPTFQDL-LNRTTAGQPTGWYKDLRHYYYRARWELYDRSRDPHETQNL--ATDPRFAQLL 461
+P F + N A + + + L+D S+DP E L A++PRF ++L
Sbjct: 470 TPNFNPVGSNGCFATHVCFCFGS--YVTHHDPPLLFDISKDPRERNPLTPASEPRFYEIL 527
Query: 462 EMLRD 466
+++++
Sbjct: 528 KVMQE 532
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 52.0 bits (123), Expect = 1e-06
Identities = 79/371 (21%), Positives = 136/371 (36%), Gaps = 61/371 (16%)
Query: 24 NALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQ 83
N +L+L DD E G+ + + + F NAF + C PSR+S+LTG
Sbjct: 45 NIILVLTDDQDVELGSMQ---VMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYV 101
Query: 84 HQNGMYGLHQDVH--HFNSFDKVRSLPLLLSQAGVRTGIIGK-------KHVGP------ 128
H + Y +++ + + + R+ + L+ G RT GK +V P
Sbjct: 102 HNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWV 161
Query: 129 -----ETVYPFDFAYTEENGSVLQVGRNITRIKL----------LVRKFLQTQDDRPFFL 173
Y + NG + G + ++ L R + RP +
Sbjct: 162 GLLKNSRFYNYTLC---RNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLM 218
Query: 174 YVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPA-- 231
++ PH S PQY F N + P + ++ Y P P
Sbjct: 219 VISHAAPHGPEDSAPQYSRL---FPNASQHI--TPSYNYAPNPDKHWIMRYTGPMKPIHM 273
Query: 232 --ARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNG-----IPFPSGRTN 284
+ T+ +D + + L + G L++T +++T+D+G G++
Sbjct: 274 EFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSM 333
Query: 285 LYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLT 344
Y P V P G ++ V +DL PTILD + P+ +
Sbjct: 334 PYEFDIRVPFYVRGPN--VEAGCLNPHIVLNIDLAPTILDIAGLDIPA---------DMD 382
Query: 345 GRSLLPALEAE 355
G+S+L L+ E
Sbjct: 383 GKSILKLLDTE 393
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 52.0 bits (123), Expect = 1e-06
Identities = 79/371 (21%), Positives = 136/371 (36%), Gaps = 61/371 (16%)
Query: 24 NALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQ 83
N +L+L DD E G+ + + + F NAF + C PSR+S+LTG
Sbjct: 45 NIILVLTDDQDVELGSMQ---VMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYV 101
Query: 84 HQNGMYGLHQDVH--HFNSFDKVRSLPLLLSQAGVRTGIIGK-------KHVGP------ 128
H + Y +++ + + + R+ + L+ G RT GK +V P
Sbjct: 102 HNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWV 161
Query: 129 -----ETVYPFDFAYTEENGSVLQVGRNITRIKL----------LVRKFLQTQDDRPFFL 173
Y + NG + G + ++ L R + RP +
Sbjct: 162 GLLKNSRFYNYTLC---RNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLM 218
Query: 174 YVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPA-- 231
++ PH S PQY F N + P + ++ Y P P
Sbjct: 219 VISHAAPHGPEDSAPQYSRL---FPNASQHI--TPSYNYAPNPDKHWIMRYTGPMKPIHM 273
Query: 232 --ARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNG-----IPFPSGRTN 284
+ T+ +D + + L + G L++T +++T+D+G G++
Sbjct: 274 EFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSM 333
Query: 285 LYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLT 344
Y P V P G ++ V +DL PTILD + P+ +
Sbjct: 334 PYEFDIRVPFYVRGPN--VEAGCLNPHIVLNIDLAPTILDIAGLDIPA---------DMD 382
Query: 345 GRSLLPALEAE 355
G+S+L L+ E
Sbjct: 383 GKSILKLLDTE 393
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 52.0 bits (123), Expect = 1e-06
Identities = 79/371 (21%), Positives = 136/371 (36%), Gaps = 61/371 (16%)
Query: 24 NALLLLADDGGFESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQ 83
N +L+L DD E G+ + + + F NAF + C PSR+S+LTG
Sbjct: 45 NIILVLTDDQDVELGSMQ---VMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYV 101
Query: 84 HQNGMYGLHQDVH--HFNSFDKVRSLPLLLSQAGVRTGIIGK-------KHVGP------ 128
H + Y +++ + + + R+ + L+ G RT GK +V P
Sbjct: 102 HNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWV 161
Query: 129 -----ETVYPFDFAYTEENGSVLQVGRNITRIKL----------LVRKFLQTQDDRPFFL 173
Y + NG + G + ++ L R + RP +
Sbjct: 162 GLLKNSRFYNYTLC---RNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPHRPVLM 218
Query: 174 YVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPA-- 231
++ PH S PQY F N + P + ++ Y P P
Sbjct: 219 VISHAAPHGPEDSAPQYSRL---FPNASQHI--TPSYNYAPNPDKHWIMRYTGPMKPIHM 273
Query: 232 --ARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFTSDNG-----IPFPSGRTN 284
+ T+ +D + + L + G L++T +++T+D+G G++
Sbjct: 274 EFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKSM 333
Query: 285 LYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLT 344
Y P V P G ++ V +DL PTILD + P+ +
Sbjct: 334 PYEFDIRVPFYVRGPN--VEAGCLNPHIVLNIDLAPTILDIAGLDIPA---------DMD 382
Query: 345 GRSLLPALEAE 355
G+S+L L+ E
Sbjct: 383 GKSILKLLDTE 393
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 48.5 bits (114), Expect = 1e-05
Identities = 37/118 (31%), Positives = 59/118 (50%), Gaps = 18/118 (15%)
Query: 45 IATPHLDALARRSLLFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFNSFDKV 104
+ P++D LA SLLF+NAF + C+PSR S LTG +Y FNS+ +V
Sbjct: 22 VKAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLY-------DFNSYWRV 74
Query: 105 R-----SLPLLLSQAGVRTGIIGKK-HVG----PETVYPFDFAYTEENGSVLQVGRNI 152
++P + G T +GK H G PE+ + + F +E + +L +G ++
Sbjct: 75 HAGNFSTIPQYFKENGYVTMSVGKVFHPGTAPRPESGFSW-FVVSESSIPILGMGLSL 131
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.443
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,278,060
Number of Sequences: 37866
Number of extensions: 1011430
Number of successful extensions: 1994
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 30
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1878
Number of HSP's gapped (non-prelim): 75
length of query: 502
length of database: 18,247,518
effective HSP length: 107
effective length of query: 395
effective length of database: 14,195,856
effective search space: 5607363120
effective search space used: 5607363120
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.