Search of human proteins with 4505751

Search of human proteins with 4505751

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505751 profilin 2 isoform b [Homo sapiens]
         (140 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505751 profilin 2 isoform b [Homo sapiens]                        290   2e-79
gi|16753215 profilin 2 isoform a [Homo sapiens]                       273   3e-74
gi|4826898 profilin 1 [Homo sapiens]                                  189   6e-49
gi|71274140 profilin 3 [Homo sapiens]                                 116   7e-27
gi|239741295 PREDICTED: similar to PDE4DIP protein [Homo sapiens]      70   6e-13
gi|14591902 RecQ protein-like [Homo sapiens]                           32   0.22 
gi|14591904 RecQ protein-like [Homo sapiens]                           32   0.22 
gi|148746189 multiple PDZ domain protein [Homo sapiens]                28   1.9  
gi|31317252 ankyrin repeat and FYVE domain containing 1 isoform ...    27   4.2  
gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform...    27   4.2  
gi|139394648 DNA polymerase theta [Homo sapiens]                       27   7.1  
gi|110349792 growth differentiation factor 1 [Homo sapiens]            26   9.3  

>gi|4505751 profilin 2 isoform b [Homo sapiens]
          Length = 140

 Score =  290 bits (743), Expect = 2e-79
 Identities = 140/140 (100%), Positives = 140/140 (100%)

Query: 1   MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFF 60
           MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFF
Sbjct: 1   MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFF 60

Query: 61  TNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVH 120
           TNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVH
Sbjct: 61  TNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVH 120

Query: 121 GGTLNKKAYELALYLRRSDV 140
           GGTLNKKAYELALYLRRSDV
Sbjct: 121 GGTLNKKAYELALYLRRSDV 140


>gi|16753215 profilin 2 isoform a [Homo sapiens]
          Length = 140

 Score =  273 bits (698), Expect = 3e-74
 Identities = 131/138 (94%), Positives = 132/138 (95%)

Query: 1   MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFF 60
           MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFF
Sbjct: 1   MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFF 60

Query: 61  TNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVH 120
           TNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGR LV VMGKEGVH
Sbjct: 61  TNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRVLVFVMGKEGVH 120

Query: 121 GGTLNKKAYELALYLRRS 138
           GG LNKKAY +A YLR S
Sbjct: 121 GGGLNKKAYSMAKYLRDS 138


>gi|4826898 profilin 1 [Homo sapiens]
          Length = 140

 Score =  189 bits (480), Expect = 6e-49
 Identities = 87/138 (63%), Positives = 108/138 (78%)

Query: 1   MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFF 60
           MAGW +Y+DNLM DG CQ+AAIVGY D+  VWAA  G  F +ITP E+ ++VGKDR  F+
Sbjct: 1   MAGWNAYIDNLMADGTCQDAAIVGYKDSPSVWAAVPGKTFVNITPAEVGVLVGKDRSSFY 60

Query: 61  TNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVH 120
            NGLTLG +KCSVIRDSL  DG+ +MD+RTKS GG PT+NV V +  + LV++MGKEGVH
Sbjct: 61  VNGLTLGGQKCSVIRDSLLQDGEFSMDLRTKSTGGAPTFNVTVTKTDKTLVLLMGKEGVH 120

Query: 121 GGTLNKKAYELALYLRRS 138
           GG +NKK YE+A +LRRS
Sbjct: 121 GGLINKKCYEMASHLRRS 138


>gi|71274140 profilin 3 [Homo sapiens]
          Length = 137

 Score =  116 bits (290), Expect = 7e-27
 Identities = 59/136 (43%), Positives = 83/136 (61%), Gaps = 3/136 (2%)

Query: 1   MAGWQSYVDNLMCDGCCQEAAIVGYCDAKYVWAATAGGVFQSITPIEIDMIVGKDREGFF 60
           M  W+ Y+  ++ D    + AIVG+ D   VWA+  GG+  +I+P E+ ++ G DR  F 
Sbjct: 1   MGDWKVYISAVLRDQRIDDVAIVGHADNSCVWASRPGGLLAAISPQEVGVLTGPDRHTFL 60

Query: 61  TNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVH 120
             GL++G ++C VIRD L  +GD  +D RTK   G     V VGRA RAL+++MG+ GVH
Sbjct: 61  QAGLSVGGRRCCVIRDHLLAEGDGVLDARTK---GLDARAVCVGRAPRALLVLMGRRGVH 117

Query: 121 GGTLNKKAYELALYLR 136
           GG LNK  +EL   LR
Sbjct: 118 GGILNKTVHELIRGLR 133


>gi|239741295 PREDICTED: similar to PDE4DIP protein [Homo sapiens]
          Length = 66

 Score = 70.1 bits (170), Expect = 6e-13
 Identities = 33/65 (50%), Positives = 44/65 (67%)

Query: 62  NGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEGVHG 121
           NGLTLG +K +V+ DSL  DG+ T D+  KS  G PT+NV V    + L ++MGKEG+HG
Sbjct: 2   NGLTLGGQKYTVVLDSLLQDGELTTDLCMKSISGAPTFNVIVTMTAKTLGLLMGKEGIHG 61

Query: 122 GTLNK 126
             +NK
Sbjct: 62  NFINK 66


>gi|14591902 RecQ protein-like [Homo sapiens]
          Length = 649

 Score = 31.6 bits (70), Expect = 0.22
 Identities = 19/57 (33%), Positives = 28/57 (49%), Gaps = 6/57 (10%)

Query: 4   WQSYVDNLMCDGCCQEAA-----IVGYCDAKYVWAATAGGVFQSITPIE-IDMIVGK 54
           W S   N MCD CC+++A     I  YC         A  + + +TP++ ID  +GK
Sbjct: 466 WNSEACNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEELNEKLTPLKLIDSWMGK 522


>gi|14591904 RecQ protein-like [Homo sapiens]
          Length = 649

 Score = 31.6 bits (70), Expect = 0.22
 Identities = 19/57 (33%), Positives = 28/57 (49%), Gaps = 6/57 (10%)

Query: 4   WQSYVDNLMCDGCCQEAA-----IVGYCDAKYVWAATAGGVFQSITPIE-IDMIVGK 54
           W S   N MCD CC+++A     I  YC         A  + + +TP++ ID  +GK
Sbjct: 466 WNSEACNKMCDNCCKDSAFERKNITEYCRDLIKILKQAEELNEKLTPLKLIDSWMGK 522


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 28.5 bits (62), Expect = 1.9
 Identities = 14/60 (23%), Positives = 27/60 (45%), Gaps = 8/60 (13%)

Query: 75   RDSLYVDGDCTMDIRTKSQGGEPTYNVAVGRAGRALVIVMGKEG--------VHGGTLNK 126
            + SL  + +C M      +  E T N+A G +   + +   K+G        +HGG +++
Sbjct: 985  QSSLACNAECVMLQNVSKESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISR 1044


>gi|31317252 ankyrin repeat and FYVE domain containing 1 isoform 2
           [Homo sapiens]
          Length = 487

 Score = 27.3 bits (59), Expect = 4.2
 Identities = 22/87 (25%), Positives = 35/87 (40%), Gaps = 9/87 (10%)

Query: 56  REGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTK---------SQGGEPTYNVAVGRA 106
           + G F N  TLGA++  +   +LY     + D+ ++           G  P    + GR 
Sbjct: 310 KNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRT 369

Query: 107 GRALVIVMGKEGVHGGTLNKKAYELAL 133
              + I+ G E V    L  K  +L L
Sbjct: 370 PLHVSIMAGNEYVFSQLLQCKQLDLEL 396


>gi|110815813 ankyrin repeat and FYVE domain containing 1 isoform 1
           [Homo sapiens]
          Length = 1170

 Score = 27.3 bits (59), Expect = 4.2
 Identities = 22/87 (25%), Positives = 35/87 (40%), Gaps = 9/87 (10%)

Query: 56  REGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTK---------SQGGEPTYNVAVGRA 106
           + G F N  TLGA++  +   +LY     + D+ ++           G  P    + GR 
Sbjct: 310 KNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRT 369

Query: 107 GRALVIVMGKEGVHGGTLNKKAYELAL 133
              + I+ G E V    L  K  +L L
Sbjct: 370 PLHVSIMAGNEYVFSQLLQCKQLDLEL 396


>gi|139394648 DNA polymerase theta [Homo sapiens]
          Length = 2590

 Score = 26.6 bits (57), Expect = 7.1
 Identities = 22/64 (34%), Positives = 28/64 (43%), Gaps = 5/64 (7%)

Query: 57  EGFFTNGLTLGAKKCSVIRDSLYVDGDCTMDIRTKSQGGEP----TYNVAVGRAGRALVI 112
           EG F  GL       S +   + +     + IRT   GG P    TY   VGRAGR  V 
Sbjct: 429 EGAFRQGLIRVLAATSTLSSGVNLPARRVI-IRTPIFGGRPLDILTYKQMVGRAGRKGVD 487

Query: 113 VMGK 116
            +G+
Sbjct: 488 TVGE 491


>gi|110349792 growth differentiation factor 1 [Homo sapiens]
          Length = 372

 Score = 26.2 bits (56), Expect = 9.3
 Identities = 11/28 (39%), Positives = 13/28 (46%)

Query: 79  YVDGDCTMDIRTKSQGGEPTYNVAVGRA 106
           Y  G C + +     GG P  N AV RA
Sbjct: 295 YCQGQCALPVALSGSGGPPALNHAVLRA 322


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.428 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 5,168,489
Number of Sequences: 37866
Number of extensions: 206019
Number of successful extensions: 286
Number of sequences better than 10.0: 12
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 277
Number of HSP's gapped (non-prelim): 13
length of query: 140
length of database: 18,247,518
effective HSP length: 92
effective length of query: 48
effective length of database: 14,763,846
effective search space: 708664608
effective search space used: 708664608
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 56 (26.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.