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Search of human proteins with 4504061
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
(552 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 1148 0.0
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 313 3e-85
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 313 3e-85
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 313 3e-85
gi|189571643 sulfatase 1 [Homo sapiens] 312 6e-85
gi|189571641 sulfatase 1 [Homo sapiens] 312 6e-85
gi|189571638 sulfatase 1 [Homo sapiens] 312 6e-85
gi|189571636 sulfatase 1 [Homo sapiens] 312 6e-85
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 77 5e-14
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 72 1e-12
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 72 1e-12
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 72 1e-12
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 72 1e-12
gi|59797060 arylsulfatase family, member I [Homo sapiens] 65 2e-10
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 65 2e-10
gi|109389362 arylsulfatase J [Homo sapiens] 65 2e-10
gi|39930577 arylsulfatase K [Homo sapiens] 65 2e-10
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 61 3e-09
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 55 2e-07
gi|45430057 Arylsulfatase G [Homo sapiens] 54 3e-07
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 53 6e-07
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 52 2e-06
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 52 2e-06
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 49 9e-06
gi|31742482 arylsulfatase F precursor [Homo sapiens] 47 6e-05
gi|157266309 arylsulfatase E precursor [Homo sapiens] 44 4e-04
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 44 5e-04
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 41 0.002
gi|58743319 arylsulfatase family, member H [Homo sapiens] 39 0.012
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 33 0.68
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 1148 bits (2970), Expect = 0.0
Identities = 552/552 (100%), Positives = 552/552 (100%)
Query: 1 MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEV 60
MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEV
Sbjct: 1 MRLLPLAPGRLRRGSPRHLPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEV 60
Query: 61 LGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSS 120
LGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSS
Sbjct: 61 LGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSS 120
Query: 121 KSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSK 180
KSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSK
Sbjct: 121 KSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSK 180
Query: 181 YYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTA 240
YYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTA
Sbjct: 181 YYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTA 240
Query: 241 APQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVD 300
APQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVD
Sbjct: 241 APQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVD 300
Query: 301 DLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIK 360
DLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIK
Sbjct: 301 DLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIK 360
Query: 361 PNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEG 420
PNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEG
Sbjct: 361 PNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLVEYQGEG 420
Query: 421 RNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYN 480
RNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYN
Sbjct: 421 RNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYN 480
Query: 481 LTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRG 540
LTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRG
Sbjct: 481 LTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDPRLMFSNRG 540
Query: 541 SVRTRRFSKHLL 552
SVRTRRFSKHLL
Sbjct: 541 SVRTRRFSKHLL 552
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 313 bits (801), Expect = 3e-85
Identities = 170/359 (47%), Positives = 218/359 (60%), Gaps = 15/359 (4%)
Query: 46 RPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPH 105
RPN++L+LTDDQD LG M + KT+ ++ + G F +A+V + +CCPSR+SILTGKY H
Sbjct: 43 RPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVH 102
Query: 106 NHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHV 165
NH+ N NCSS SWQ E TF L S GY+T F GKYLNEY +V
Sbjct: 103 NHNTYTNN--ENCSSPSWQAQHESRTFAVYLNST-GYRTAFFGKYLNEYNG------SYV 153
Query: 166 PLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNF--- 222
P GW W L KNS++YNYTL NG KHG +YS DYLTD++ N S+ F
Sbjct: 154 PPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPH 213
Query: 223 EPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIH-GTNKHWLIRQAKTPMTNSS 281
P M+I+ APH P +APQY + F N ++N +KHW++R PM
Sbjct: 214 RPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTG-PMKPIH 272
Query: 282 IQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKR 341
++F + RKR QTL+SVDD +E + L TGEL+NTYI YT+D+GYH GQF L K
Sbjct: 273 MEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKS 332
Query: 342 QLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPIL 400
YEFDI+VP VRGP ++ + +V NIDL PTILDIAG D+ MDG S+L +L
Sbjct: 333 MPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDI-PADMDGKSILKLL 390
Score = 67.8 bits (164), Expect = 2e-11
Identities = 31/76 (40%), Positives = 47/76 (61%), Gaps = 2/76 (2%)
Query: 440 PDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPEL 499
P C C A NNTY C+RT++ N +CEF F+E ++L DP Q+ N T+D ++
Sbjct: 745 PFCACTSANNNTYWCMRTINETHNFLFCEFATG--FLEYFDLNTDPYQLMNAVNTLDRDV 802
Query: 500 LGKMNYRLMMLQSCSG 515
L +++ +LM L+SC G
Sbjct: 803 LNQLHVQLMELRSCKG 818
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 313 bits (801), Expect = 3e-85
Identities = 170/359 (47%), Positives = 218/359 (60%), Gaps = 15/359 (4%)
Query: 46 RPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPH 105
RPN++L+LTDDQD LG M + KT+ ++ + G F +A+V + +CCPSR+SILTGKY H
Sbjct: 43 RPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVH 102
Query: 106 NHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHV 165
NH+ N NCSS SWQ E TF L S GY+T F GKYLNEY +V
Sbjct: 103 NHNTYTNN--ENCSSPSWQAQHESRTFAVYLNST-GYRTAFFGKYLNEYNG------SYV 153
Query: 166 PLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNF--- 222
P GW W L KNS++YNYTL NG KHG +YS DYLTD++ N S+ F
Sbjct: 154 PPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPH 213
Query: 223 EPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIH-GTNKHWLIRQAKTPMTNSS 281
P M+I+ APH P +APQY + F N ++N +KHW++R PM
Sbjct: 214 RPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTG-PMKPIH 272
Query: 282 IQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKR 341
++F + RKR QTL+SVDD +E + L TGEL+NTYI YT+D+GYH GQF L K
Sbjct: 273 MEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKS 332
Query: 342 QLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPIL 400
YEFDI+VP VRGP ++ + +V NIDL PTILDIAG D+ MDG S+L +L
Sbjct: 333 MPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDI-PADMDGKSILKLL 390
Score = 67.8 bits (164), Expect = 2e-11
Identities = 31/76 (40%), Positives = 47/76 (61%), Gaps = 2/76 (2%)
Query: 440 PDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPEL 499
P C C A NNTY C+RT++ N +CEF F+E ++L DP Q+ N T+D ++
Sbjct: 745 PFCACTSANNNTYWCMRTINETHNFLFCEFATG--FLEYFDLNTDPYQLMNAVNTLDRDV 802
Query: 500 LGKMNYRLMMLQSCSG 515
L +++ +LM L+SC G
Sbjct: 803 LNQLHVQLMELRSCKG 818
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 313 bits (801), Expect = 3e-85
Identities = 170/359 (47%), Positives = 218/359 (60%), Gaps = 15/359 (4%)
Query: 46 RPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPH 105
RPN++L+LTDDQD LG M + KT+ ++ + G F +A+V + +CCPSR+SILTGKY H
Sbjct: 43 RPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKYVH 102
Query: 106 NHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHV 165
NH+ N NCSS SWQ E TF L S GY+T F GKYLNEY +V
Sbjct: 103 NHNTYTNN--ENCSSPSWQAQHESRTFAVYLNST-GYRTAFFGKYLNEYNG------SYV 153
Query: 166 PLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNF--- 222
P GW W L KNS++YNYTL NG KHG +YS DYLTD++ N S+ F
Sbjct: 154 PPGWKEWVGLLKNSRFYNYTLCRNGVKEKHGSDYSKDYLTDLITNDSVSFFRTSKKMYPH 213
Query: 223 EPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIH-GTNKHWLIRQAKTPMTNSS 281
P M+I+ APH P +APQY + F N ++N +KHW++R PM
Sbjct: 214 RPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWIMRYTG-PMKPIH 272
Query: 282 IQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKR 341
++F + RKR QTL+SVDD +E + L TGEL+NTYI YT+D+GYH GQF L K
Sbjct: 273 MEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYHIGQFGLVKGKS 332
Query: 342 QLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPIL 400
YEFDI+VP VRGP ++ + +V NIDL PTILDIAG D+ MDG S+L +L
Sbjct: 333 MPYEFDIRVPFYVRGPNVEAGCLNPHIVLNIDLAPTILDIAGLDI-PADMDGKSILKLL 390
Score = 67.8 bits (164), Expect = 2e-11
Identities = 31/76 (40%), Positives = 47/76 (61%), Gaps = 2/76 (2%)
Query: 440 PDCVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPEL 499
P C C A NNTY C+RT++ N +CEF F+E ++L DP Q+ N T+D ++
Sbjct: 745 PFCACTSANNNTYWCMRTINETHNFLFCEFATG--FLEYFDLNTDPYQLMNAVNTLDRDV 802
Query: 500 LGKMNYRLMMLQSCSG 515
L +++ +LM L+SC G
Sbjct: 803 LNQLHVQLMELRSCKG 818
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 312 bits (799), Expect = 6e-85
Identities = 164/359 (45%), Positives = 220/359 (61%), Gaps = 15/359 (4%)
Query: 46 RPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPH 105
RPN++L+LTDDQD LG + + KT+ ++ G TF +A+V + +CCPSR+S+LTGKY H
Sbjct: 42 RPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVH 101
Query: 106 NHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHV 165
NH+V N NCSS SWQ + EP TF L + GY+T F GKYLNEY ++
Sbjct: 102 NHNVYTNN--ENCSSPSWQAMHEPRTFAVYLNNT-GYRTAFFGKYLNEYNG------SYI 152
Query: 166 PLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNF--- 222
P GW W L KNS++YNYT+ NG KHG +Y+ DY TD++ N S+++
Sbjct: 153 PPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPH 212
Query: 223 EPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIH-GTNKHWLIRQAKTPMTNSS 281
P M+I+ APH P +APQ+ K + N ++N +KHW++ Q PM
Sbjct: 213 RPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIM-QYTGPMLPIH 271
Query: 282 IQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKR 341
++F + RKR QTL+SVDD VE+L L TGEL NTYI YT+D+GYH GQF L K
Sbjct: 272 MEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKS 331
Query: 342 QLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPIL 400
Y+FDI+VP +RGP ++P +V NIDL PTILDIAG D +DG S+L +L
Sbjct: 332 MPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLD-TPPDVDGKSVLKLL 389
Score = 63.9 bits (154), Expect = 4e-10
Identities = 28/74 (37%), Positives = 46/74 (62%), Gaps = 2/74 (2%)
Query: 442 CVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLG 501
C C + NNTY C+RT++ N +CEF F+E +++ DP Q+TN T++ +L
Sbjct: 766 CACTSSNNNTYWCLRTVNETHNFLFCEFATG--FLEYFDMNTDPYQLTNTVHTVERGILN 823
Query: 502 KMNYRLMMLQSCSG 515
+++ +LM L+SC G
Sbjct: 824 QLHVQLMELRSCQG 837
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 312 bits (799), Expect = 6e-85
Identities = 164/359 (45%), Positives = 220/359 (61%), Gaps = 15/359 (4%)
Query: 46 RPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPH 105
RPN++L+LTDDQD LG + + KT+ ++ G TF +A+V + +CCPSR+S+LTGKY H
Sbjct: 42 RPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVH 101
Query: 106 NHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHV 165
NH+V N NCSS SWQ + EP TF L + GY+T F GKYLNEY ++
Sbjct: 102 NHNVYTNN--ENCSSPSWQAMHEPRTFAVYLNNT-GYRTAFFGKYLNEYNG------SYI 152
Query: 166 PLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNF--- 222
P GW W L KNS++YNYT+ NG KHG +Y+ DY TD++ N S+++
Sbjct: 153 PPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPH 212
Query: 223 EPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIH-GTNKHWLIRQAKTPMTNSS 281
P M+I+ APH P +APQ+ K + N ++N +KHW++ Q PM
Sbjct: 213 RPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIM-QYTGPMLPIH 271
Query: 282 IQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKR 341
++F + RKR QTL+SVDD VE+L L TGEL NTYI YT+D+GYH GQF L K
Sbjct: 272 MEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKS 331
Query: 342 QLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPIL 400
Y+FDI+VP +RGP ++P +V NIDL PTILDIAG D +DG S+L +L
Sbjct: 332 MPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLD-TPPDVDGKSVLKLL 389
Score = 63.9 bits (154), Expect = 4e-10
Identities = 28/74 (37%), Positives = 46/74 (62%), Gaps = 2/74 (2%)
Query: 442 CVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLG 501
C C + NNTY C+RT++ N +CEF F+E +++ DP Q+TN T++ +L
Sbjct: 766 CACTSSNNNTYWCLRTVNETHNFLFCEFATG--FLEYFDMNTDPYQLTNTVHTVERGILN 823
Query: 502 KMNYRLMMLQSCSG 515
+++ +LM L+SC G
Sbjct: 824 QLHVQLMELRSCQG 837
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 312 bits (799), Expect = 6e-85
Identities = 164/359 (45%), Positives = 220/359 (61%), Gaps = 15/359 (4%)
Query: 46 RPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPH 105
RPN++L+LTDDQD LG + + KT+ ++ G TF +A+V + +CCPSR+S+LTGKY H
Sbjct: 42 RPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVH 101
Query: 106 NHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHV 165
NH+V N NCSS SWQ + EP TF L + GY+T F GKYLNEY ++
Sbjct: 102 NHNVYTNN--ENCSSPSWQAMHEPRTFAVYLNNT-GYRTAFFGKYLNEYNG------SYI 152
Query: 166 PLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNF--- 222
P GW W L KNS++YNYT+ NG KHG +Y+ DY TD++ N S+++
Sbjct: 153 PPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPH 212
Query: 223 EPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIH-GTNKHWLIRQAKTPMTNSS 281
P M+I+ APH P +APQ+ K + N ++N +KHW++ Q PM
Sbjct: 213 RPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIM-QYTGPMLPIH 271
Query: 282 IQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKR 341
++F + RKR QTL+SVDD VE+L L TGEL NTYI YT+D+GYH GQF L K
Sbjct: 272 MEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKS 331
Query: 342 QLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPIL 400
Y+FDI+VP +RGP ++P +V NIDL PTILDIAG D +DG S+L +L
Sbjct: 332 MPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLD-TPPDVDGKSVLKLL 389
Score = 63.9 bits (154), Expect = 4e-10
Identities = 28/74 (37%), Positives = 46/74 (62%), Gaps = 2/74 (2%)
Query: 442 CVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLG 501
C C + NNTY C+RT++ N +CEF F+E +++ DP Q+TN T++ +L
Sbjct: 766 CACTSSNNNTYWCLRTVNETHNFLFCEFATG--FLEYFDMNTDPYQLTNTVHTVERGILN 823
Query: 502 KMNYRLMMLQSCSG 515
+++ +LM L+SC G
Sbjct: 824 QLHVQLMELRSCQG 837
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 312 bits (799), Expect = 6e-85
Identities = 164/359 (45%), Positives = 220/359 (61%), Gaps = 15/359 (4%)
Query: 46 RPNVVLLLTDDQDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPH 105
RPN++L+LTDDQD LG + + KT+ ++ G TF +A+V + +CCPSR+S+LTGKY H
Sbjct: 42 RPNIILVLTDDQDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKYVH 101
Query: 106 NHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDAGGLEHV 165
NH+V N NCSS SWQ + EP TF L + GY+T F GKYLNEY ++
Sbjct: 102 NHNVYTNN--ENCSSPSWQAMHEPRTFAVYLNNT-GYRTAFFGKYLNEYNG------SYI 152
Query: 166 PLGWSYWYALEKNSKYYNYTLSINGKARKHGENYSVDYLTDVLANVSLDFLDYKSNF--- 222
P GW W L KNS++YNYT+ NG KHG +Y+ DY TD++ N S+++
Sbjct: 153 PPGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKRMYPH 212
Query: 223 EPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIH-GTNKHWLIRQAKTPMTNSS 281
P M+I+ APH P +APQ+ K + N ++N +KHW++ Q PM
Sbjct: 213 RPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIM-QYTGPMLPIH 271
Query: 282 IQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKR 341
++F + RKR QTL+SVDD VE+L L TGEL NTYI YT+D+GYH GQF L K
Sbjct: 272 MEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIGQFGLVKGKS 331
Query: 342 QLYEFDIKVPLLVRGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPIL 400
Y+FDI+VP +RGP ++P +V NIDL PTILDIAG D +DG S+L +L
Sbjct: 332 MPYDFDIRVPFFIRGPSVEPGSIVPQIVLNIDLAPTILDIAGLD-TPPDVDGKSVLKLL 389
Score = 63.9 bits (154), Expect = 4e-10
Identities = 28/74 (37%), Positives = 46/74 (62%), Gaps = 2/74 (2%)
Query: 442 CVCEDAYNNTYACVRTMSALWNLQYCEFDDQEVFVEVYNLTADPDQITNIAKTIDPELLG 501
C C + NNTY C+RT++ N +CEF F+E +++ DP Q+TN T++ +L
Sbjct: 766 CACTSSNNNTYWCLRTVNETHNFLFCEFATG--FLEYFDMNTDPYQLTNTVHTVERGILN 823
Query: 502 KMNYRLMMLQSCSG 515
+++ +LM L+SC G
Sbjct: 824 QLHVQLMELRSCQG 837
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 76.6 bits (187), Expect = 5e-14
Identities = 105/418 (25%), Positives = 171/418 (40%), Gaps = 102/418 (24%)
Query: 27 LLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGGM--TPLKKTKAL--IGEMGMTFS 82
LLLVL G + + PN++LLL DD G+ P ++T L + G+ F
Sbjct: 13 LLLVLSAA--GMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFP 70
Query: 83 SAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQE--------PNTFPA 134
+ Y + LC PSRA++LTG+ P + N N +++ QE P
Sbjct: 71 NFYSANPLCSPSRAALLTGRLP----IRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPE 126
Query: 135 ILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKAR- 193
+L+ GY + GK+ + P L+H G+ W+ N + Y + KAR
Sbjct: 127 LLKK-AGYVSKIVGKWHLGH-RPQFHPLKH---GFDEWFG-SPNCHFGPY----DNKARP 176
Query: 194 ------------KHGENYSVDY------LTDVLANVSLDFLDYKSNFEPFFMMIATPAPH 235
++ E + ++ LT + +LDF+ ++ PFF+ A A H
Sbjct: 177 NIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATH 236
Query: 236 SPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRW-Q 294
+P V+A S FL + R R+
Sbjct: 237 AP-------------VYA---------------------------SKPFLGTSQRGRYGD 256
Query: 295 TLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLP----------IDKRQLY 344
+ +DD + K+++ L+ +NT++F+TSDNG S P K+ +
Sbjct: 257 AVREIDDSIGKILELLQDLHVADNTFVFFTSDNG--AALISAPEQGGSNGPFLCGKQTTF 314
Query: 345 EFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGY-DLNKTQMDGMSLLPIL 400
E ++ P L PG + Q S L + +DL T L +AG + +DG++LLP L
Sbjct: 315 EGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTL 372
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 72.0 bits (175), Expect = 1e-12
Identities = 103/399 (25%), Positives = 168/399 (42%), Gaps = 56/399 (14%)
Query: 23 SPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEV-LGGMTPLKKTKALIGEM---G 78
+P LLL L L V R PN+VL+ DD LG T + ++ G
Sbjct: 3 APRSLLLALAAGLAV------ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGG 56
Query: 79 MTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRS 138
+ F+ YVP +LC PSRA++LTG+ P + L SS+ ++E A + +
Sbjct: 57 LRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVP--SSRGGLPLEEVTV--AEVLA 112
Query: 139 MCGYQTFFAGKY---LNEYGA---PDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKA 192
GY T AGK+ + GA P G + + +S+ +N + +G
Sbjct: 113 ARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDG-- 170
Query: 193 RKHGENYSVDYLTDVLANVSLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNV 251
G + + + +LAN+S++ + E +M A H A + + F
Sbjct: 171 ---GCDQGLVPIP-LLANLSVEAQPPWLPGLEARYMAFA----HDLMADAQRQDRPFFLY 222
Query: 252 FAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLE 311
+A + ++ + + + R + P +S L+ +D V L+ +
Sbjct: 223 YASHHTHYP-QFSGQSFAERSGRGPFGDS---------------LMELDAAVGTLMTAIG 266
Query: 312 FTGELNNTYIFYTSDNGYHTGQFS-------LPIDKRQLYEFDIKVPLLVRGPG-IKPNQ 363
G L T + +T+DNG T + S L K YE ++ P L PG I P
Sbjct: 267 DLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV 326
Query: 364 TSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRG 402
T + L +++DL PT+ +AG L +DG L P+L G
Sbjct: 327 THE-LASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLG 364
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 72.0 bits (175), Expect = 1e-12
Identities = 103/399 (25%), Positives = 168/399 (42%), Gaps = 56/399 (14%)
Query: 23 SPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEV-LGGMTPLKKTKALIGEM---G 78
+P LLL L L V R PN+VL+ DD LG T + ++ G
Sbjct: 3 APRSLLLALAAGLAV------ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGG 56
Query: 79 MTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRS 138
+ F+ YVP +LC PSRA++LTG+ P + L SS+ ++E A + +
Sbjct: 57 LRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVP--SSRGGLPLEEVTV--AEVLA 112
Query: 139 MCGYQTFFAGKY---LNEYGA---PDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKA 192
GY T AGK+ + GA P G + + +S+ +N + +G
Sbjct: 113 ARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDG-- 170
Query: 193 RKHGENYSVDYLTDVLANVSLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNV 251
G + + + +LAN+S++ + E +M A H A + + F
Sbjct: 171 ---GCDQGLVPIP-LLANLSVEAQPPWLPGLEARYMAFA----HDLMADAQRQDRPFFLY 222
Query: 252 FAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLE 311
+A + ++ + + + R + P +S L+ +D V L+ +
Sbjct: 223 YASHHTHYP-QFSGQSFAERSGRGPFGDS---------------LMELDAAVGTLMTAIG 266
Query: 312 FTGELNNTYIFYTSDNGYHTGQFS-------LPIDKRQLYEFDIKVPLLVRGPG-IKPNQ 363
G L T + +T+DNG T + S L K YE ++ P L PG I P
Sbjct: 267 DLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV 326
Query: 364 TSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRG 402
T + L +++DL PT+ +AG L +DG L P+L G
Sbjct: 327 THE-LASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLG 364
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 72.0 bits (175), Expect = 1e-12
Identities = 103/399 (25%), Positives = 168/399 (42%), Gaps = 56/399 (14%)
Query: 23 SPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEV-LGGMTPLKKTKALIGEM---G 78
+P LLL L L V R PN+VL+ DD LG T + ++ G
Sbjct: 3 APRSLLLALAAGLAV------ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGG 56
Query: 79 MTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRS 138
+ F+ YVP +LC PSRA++LTG+ P + L SS+ ++E A + +
Sbjct: 57 LRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVP--SSRGGLPLEEVTV--AEVLA 112
Query: 139 MCGYQTFFAGKY---LNEYGA---PDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKA 192
GY T AGK+ + GA P G + + +S+ +N + +G
Sbjct: 113 ARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDG-- 170
Query: 193 RKHGENYSVDYLTDVLANVSLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNV 251
G + + + +LAN+S++ + E +M A H A + + F
Sbjct: 171 ---GCDQGLVPIP-LLANLSVEAQPPWLPGLEARYMAFA----HDLMADAQRQDRPFFLY 222
Query: 252 FAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLE 311
+A + ++ + + + R + P +S L+ +D V L+ +
Sbjct: 223 YASHHTHYP-QFSGQSFAERSGRGPFGDS---------------LMELDAAVGTLMTAIG 266
Query: 312 FTGELNNTYIFYTSDNGYHTGQFS-------LPIDKRQLYEFDIKVPLLVRGPG-IKPNQ 363
G L T + +T+DNG T + S L K YE ++ P L PG I P
Sbjct: 267 DLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV 326
Query: 364 TSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRG 402
T + L +++DL PT+ +AG L +DG L P+L G
Sbjct: 327 THE-LASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLG 364
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 72.0 bits (175), Expect = 1e-12
Identities = 103/399 (25%), Positives = 168/399 (42%), Gaps = 56/399 (14%)
Query: 23 SPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEV-LGGMTPLKKTKALIGEM---G 78
+P LLL L L V R PN+VL+ DD LG T + ++ G
Sbjct: 3 APRSLLLALAAGLAV------ARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGG 56
Query: 79 MTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRS 138
+ F+ YVP +LC PSRA++LTG+ P + L SS+ ++E A + +
Sbjct: 57 LRFTDFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVP--SSRGGLPLEEVTV--AEVLA 112
Query: 139 MCGYQTFFAGKY---LNEYGA---PDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKA 192
GY T AGK+ + GA P G + + +S+ +N + +G
Sbjct: 113 ARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDG-- 170
Query: 193 RKHGENYSVDYLTDVLANVSLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNV 251
G + + + +LAN+S++ + E +M A H A + + F
Sbjct: 171 ---GCDQGLVPIP-LLANLSVEAQPPWLPGLEARYMAFA----HDLMADAQRQDRPFFLY 222
Query: 252 FAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLE 311
+A + ++ + + + R + P +S L+ +D V L+ +
Sbjct: 223 YASHHTHYP-QFSGQSFAERSGRGPFGDS---------------LMELDAAVGTLMTAIG 266
Query: 312 FTGELNNTYIFYTSDNGYHTGQFS-------LPIDKRQLYEFDIKVPLLVRGPG-IKPNQ 363
G L T + +T+DNG T + S L K YE ++ P L PG I P
Sbjct: 267 DLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV 326
Query: 364 TSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRG 402
T + L +++DL PT+ +AG L +DG L P+L G
Sbjct: 327 THE-LASSLDLLPTLAALAGAPLPNVTLDGFDLSPLLLG 364
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 65.1 bits (157), Expect = 2e-10
Identities = 90/389 (23%), Positives = 153/389 (39%), Gaps = 81/389 (20%)
Query: 41 AAGTRRPNVVLLLTDDQ---DEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRAS 97
AA + P+++ +LTDDQ D G T + G+ + Y+ +C PSR+
Sbjct: 41 AAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYI-QPICTPSRSQ 99
Query: 98 ILTGKYPHN---HHVVNNTLEGNCSSKSW----QKIQEPNTFPAILRSMCGYQTFFAGK- 149
+LTG+Y + H + + NC QK+QE GY T GK
Sbjct: 100 LLTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQE-----------AGYSTHMVGKW 148
Query: 150 ---YLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTL----SINGKARKHGENY--- 199
+ + P G + ++ +L N YY Y + G GEN
Sbjct: 149 HLGFYRKECLPTRRGFD------TFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWG 202
Query: 200 -SVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKN 258
S Y T + A + L S P F+ +A A H+P + +Y ++
Sbjct: 203 LSGQYSTMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRT-------- 254
Query: 259 FNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLS-VDDLVEKLVKRLEFTGELN 317
+ N R+++ +++ +D+ V + L+ G N
Sbjct: 255 --------------------------MGNVARRKYAAMVTCMDEAVRNITWALKRYGFYN 288
Query: 318 NTYIFYTSDNGYHT--GQFSLPIDKRQ--LYEFDIKVPLLVRGPGIKPNQ-TSKMLVANI 372
N+ I ++SDNG T G + P+ R+ +E ++ V P +K Q TS+ L+
Sbjct: 289 NSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHIT 348
Query: 373 DLGPTILDIAGYDLNKTQ-MDGMSLLPIL 400
D PT++ +AG + +DG + P +
Sbjct: 349 DWYPTLVGLAGGTTSAADGLDGYDVWPAI 377
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 65.1 bits (157), Expect = 2e-10
Identities = 108/401 (26%), Positives = 157/401 (39%), Gaps = 72/401 (17%)
Query: 19 LPSCSPALLLLVLGGCLGVFGVAAGTRRPNVVLLLTDD---QDEVLGGMTPLKKTKALIG 75
+P+C LLLVLG C R N +LLL DD + +
Sbjct: 5 VPAC--CALLLVLGLCRA--------RPRNALLLLADDGGFESGAYNNSAIATPHLDALA 54
Query: 76 EMGMTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAI 135
+ F +A+ + C PSRAS+LTG P + + + + S+ K++ + P +
Sbjct: 55 RRSLLFRNAFTSVSSCSPSRASLLTG-LPQHQNGMYGLHQDVHHFNSFDKVR---SLPLL 110
Query: 136 LRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARKH 195
L S G +T GK +HV G Y + + YT NG +
Sbjct: 111 L-SQAGVRTGIIGK-------------KHV--GPETVYPFD-----FAYTEE-NGSVLQV 148
Query: 196 GENYSVDYLTDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPR 255
G N +T + V FL + + PFF+ +A PH + PQY F F
Sbjct: 149 GRN-----ITRIKLLVR-KFLQTQDD-RPFFLYVAFHDPHRCGHSQPQYG-TFCEKFGNG 200
Query: 256 NKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKR------WQTLLSVDDLVEKLVKR 309
G W QA P+ F+ N R + T+ +D V +++
Sbjct: 201 ESGM---GRIPDWT-PQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQE 256
Query: 310 LEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDIKVPLLVRGP--GIKPNQTSKM 367
L G LN+T + +TSDNG P + LY PLLV P + Q S+
Sbjct: 257 LRDAGVLNDTLVIFTSDNG-----IPFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEA 311
Query: 368 LVANIDLGPTILD--------IAGYDLNKTQMDGMSLLPIL 400
V+ +DL PTILD A + + G SLLP L
Sbjct: 312 YVSLLDLTPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPAL 352
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 64.7 bits (156), Expect = 2e-10
Identities = 119/542 (21%), Positives = 207/542 (38%), Gaps = 119/542 (21%)
Query: 44 TRRPNVVLLLTDDQ---DEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILT 100
T +P+++ +L DDQ D G T + G+ + YV +C PSR+ +T
Sbjct: 73 TSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYV-QPICTPSRSQFIT 131
Query: 101 GKYPHN---HHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGK----YLNE 153
GKY + H + + NC + T P L+ + GY T GK + +
Sbjct: 132 GKYQIHTGLQHSIIRPTQPNCLP------LDNATLPQKLKEV-GYSTHMVGKWHLGFYRK 184
Query: 154 YGAPDAGGLEHVPLGWSYWYALEKNSKYYNY----TLSINGKARKHGENYSVD-----YL 204
P G + +++ +L + YY + + + G +N + D Y
Sbjct: 185 ECMPTRRGFD------TFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYS 238
Query: 205 TDVLANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGT 264
T + L + +P F+ IA A HSP A +Y + ++++
Sbjct: 239 TQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSII------------ 286
Query: 265 NKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLS-VDDLVEKLVKRLEFTGELNNTYIFY 323
N R+R+ +LS +D+ + + L+ G NN+ I Y
Sbjct: 287 ----------------------NINRRRYAAMLSCLDEAINNVTLALKTYGFYNNSIIIY 324
Query: 324 TSDNGYH--TGQFSLPI--DKRQLYEFDIKVPLLVRGPGIKPNQT-SKMLVANIDLGPTI 378
+SDNG G + P+ K +E I+ V P +K T K LV D PT+
Sbjct: 325 SSDNGGQPTAGGSNWPLRGSKGTYWEGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTL 384
Query: 379 LDIA-----------GYDLNKTQMDGM---------SLLPILRGASNLTWRSDVLVEYQG 418
+ +A GYD+ +T +G+ ++ PI A N +W + +
Sbjct: 385 ISLAEGQIDEDIQLDGYDIWETISEGLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTA 444
Query: 419 --EGRNVTDPTCPSLSPGVSQCFP----DCVCEDAYNNTYACVRTMSALWNLQYCEFDDQ 472
V + +PG S P + + ++N + T ++W
Sbjct: 445 IQSAIRVQHWKLLTGNPGYSDWVPPQSFSNLGPNRWHNERITLSTGKSVW---------- 494
Query: 473 EVFVEVYNLTADPDQITNIAKTIDPELLGKMNYRLMMLQSCSGPTCRTPGVFDPGYRFDP 532
++N+TADP + +++ P ++ K+ RL + P P DP R +P
Sbjct: 495 -----LFNITADPYERVDLSNRY-PGIVKKLLRRLSQFNKTAVPVRYPPK--DP--RSNP 544
Query: 533 RL 534
RL
Sbjct: 545 RL 546
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 64.7 bits (156), Expect = 2e-10
Identities = 59/214 (27%), Positives = 106/214 (49%), Gaps = 39/214 (18%)
Query: 300 DDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQ-----LYEFDIKVPLLV 354
D ++ +++ L L T + Y+SD+G L ++ RQ +YE VPLL+
Sbjct: 287 DAMLGEIILALHQLDLLQKTIVIYSSDHG------ELAMEHRQFYKMSMYEASAHVPLLM 340
Query: 355 RGPGIKPNQTSKMLVANIDLGPTILDIAGYDLNKTQMDGMSLLPILRGASNLTWRSDVLV 414
GPGIK +V+ +D+ PT+LDIAG L + + G SLLP+ S+ T++++ V
Sbjct: 341 MGPGIKAGLQVSNVVSLVDIYPTMLDIAGIPLPQ-NLSGYSLLPL----SSETFKNEHKV 395
Query: 415 EYQGEGRNVTDPTCPSLSPGVSQCFPDCVCEDAYNNTYACVRTMSALWNLQYCEFDD-QE 473
+N+ P S G + N + +RT + +Y + D
Sbjct: 396 ------KNLHPPWILSEFHGCN-----------VNASTYMLRTN----HWKYIAYSDGAS 434
Query: 474 VFVEVYNLTADPDQITNIAKTIDPELLGKMNYRL 507
+ ++++L++DPD++TN+A PE+ ++ +L
Sbjct: 435 ILPQLFDLSSDPDELTNVAVKF-PEITYSLDQKL 467
Score = 42.7 bits (99), Expect = 9e-04
Identities = 31/104 (29%), Positives = 47/104 (45%), Gaps = 10/104 (9%)
Query: 35 LGVFGVAAGTRR------PNVVLLLTDDQDEVL----GGMTPLKKTKALIGEMGMTFSSA 84
L V AG +R PNVVL+++D D L G + G +F +A
Sbjct: 14 LAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFINFMKTRGTSFLNA 73
Query: 85 YVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQE 128
Y S +CCPSRA++ +G + H NN + + +W + E
Sbjct: 74 YTNSPICCPSRAAMWSGLFTHLTESWNNFKGLDPNYTTWMDVME 117
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 60.8 bits (146), Expect = 3e-09
Identities = 98/427 (22%), Positives = 167/427 (39%), Gaps = 75/427 (17%)
Query: 46 RPNVVLLLTDD----QDEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTG 101
RPN++L++ DD G T + G+ + S LC PSRA+ +TG
Sbjct: 26 RPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTG 85
Query: 102 KYPHNHHVVNNTLEGNC--SSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPDA 159
+YP + + + G ++ S + TF +L+ GY T GK+
Sbjct: 86 RYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQ-GYSTALIGKWHLGMSCHSK 144
Query: 160 GGLEHVPL--GWSYWYALEKNS------------------------KYYNYTL----SIN 189
H PL G++Y+Y + + + TL ++N
Sbjct: 145 TDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALN 204
Query: 190 GKARKH---GENYSVDYLTDVLANVSLDFLDYKSNFEPFFM----MIATPAPHSPWTAAP 242
H G +S+ +L ++ + L FL Y F M +I P + T
Sbjct: 205 CLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRL 264
Query: 243 QYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRW----QTLLS 298
+ A F RN T +L+ + + + D A + + +
Sbjct: 265 TVEAA---QFIQRN-------TETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEE 314
Query: 299 VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPID------------KRQLYEF 346
+D V +++ L+ N+T I++TSD G H + S + K +E
Sbjct: 315 MDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEG 374
Query: 347 DIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNKTQ-MDGMSLLPILRGAS 404
I+VP ++R P I+ Q +N+D+ PT+ +AG L + + +DG L+P+L G S
Sbjct: 375 GIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKS 434
Query: 405 NLTWRSD 411
RSD
Sbjct: 435 Q---RSD 438
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 55.1 bits (131), Expect = 2e-07
Identities = 93/420 (22%), Positives = 155/420 (36%), Gaps = 78/420 (18%)
Query: 28 LLVLGGCLGVFGVAAGTRRP--------NVVLLLTDDQDEVLGGMTPLKKTKALIGEMG- 78
LL LG L VA G+ NV+L++ DD LG I ++
Sbjct: 10 LLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLAS 69
Query: 79 --MTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPN--TFPA 134
+ F +A+ A+C PSR S LTG+ P + + S+ ++ N T P
Sbjct: 70 HSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYD--------FNSYWRVHAGNFSTIPQ 121
Query: 135 ILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARK 194
+ GY T GK + + + P WS+ + KY N
Sbjct: 122 YFKEN-GYVTMSVGKVF--HPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGEL 178
Query: 195 HGENYSVDYLTDV---------LANVSLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQY 244
H + DV ++ L+ K++ PFF+ + PH P+ ++
Sbjct: 179 HANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEF 238
Query: 245 QKAF--QNV-FAPRNK---NFNIHGTNKHWLIRQAK--------TPMTNSSIQFLDNAFR 290
QK + +N+ AP + N IRQ + P + F +
Sbjct: 239 QKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQ 298
Query: 291 KRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQLYEFDI-- 348
+ ++ +D V +L+ L+ N+T I +TSD+G+ G+ + + FD+
Sbjct: 299 SYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWALGEHG---EWAKYSNFDVAT 355
Query: 349 KVPLLVRGPG-------------------------IKPNQTSKMLVANIDLGPTILDIAG 383
VPL+ PG ++P + S LV + L PT+ +AG
Sbjct: 356 HVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLVELVSLFPTLAGLAG 415
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 54.3 bits (129), Expect = 3e-07
Identities = 96/400 (24%), Positives = 170/400 (42%), Gaps = 58/400 (14%)
Query: 38 FGVAAGTR--RPNVVLLLTDDQD-EVLGGMTPLKKTKALIGEM---GMTFSSAYVPSALC 91
F ++ TR +PN V++L DD LG K A + +M GM F + ++ C
Sbjct: 25 FCISGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTC 84
Query: 92 CPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKY- 150
PSRAS+LTG+ + N + N + S + T A + GY T GK+
Sbjct: 85 SPSRASLLTGRLG-----LRNGVTRNFAVTSVGGLPLNETTLAEVLQQAGYVTGIIGKWH 139
Query: 151 LNEYGA--PDAGGLEHVPLGWSYWYALE-KNSKYYNYTLSINGKARKHGENYSVDYLTDV 207
L +G+ P+ G ++ G Y + + ++ YN+ A G+ S + D
Sbjct: 140 LGHHGSYHPNFRGFDYY-FGIPYSHDMGCTDTPGYNHPPC---PACPQGDGPSRNLQRDC 195
Query: 208 LANVSLDFLDYKSNFEPFFMMIATPAPHSPWTAAPQY-QKAFQNV--FAPRNKNFNIHGT 264
+V+L + + E P + + A +Y +KA Q + + + F ++
Sbjct: 196 YTDVALPLYENLNIVEQ---------PVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVA 246
Query: 265 NKHWLIRQAKTPMTNSSIQFLDNAFRKRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYT 324
H + P+ + + L +D LV ++ +++ T + NT++++T
Sbjct: 247 LAHMHV-----PLPVTQLPAAPRGRSLYGAGLWEMDSLVGQIKDKVDHTVK-ENTFLWFT 300
Query: 325 SDNG------------------YHTGQFSLPIDKRQLYEFDIKVPLLVRGPGIKP-NQTS 365
DNG + T Q P K+ +E +VP L PG P N TS
Sbjct: 301 GDNGPWAQKCELAGSVGPFTGFWQTRQGGSPA-KQTTWEGGHRVPALAYWPGRVPVNVTS 359
Query: 366 KMLVANIDLGPTILDIAGYDLNK-TQMDGMSLLPILRGAS 404
L++ +D+ PT++ +A L + + DG+ + +L G S
Sbjct: 360 TALLSVLDIFPTVVALAQASLPQGRRFDGVDVSEVLFGRS 399
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 53.1 bits (126), Expect = 6e-07
Identities = 42/134 (31%), Positives = 63/134 (47%), Gaps = 15/134 (11%)
Query: 283 QFLDNAFRKR------WQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFS- 335
QF +F +R +L+ +D V L+ + G L T + +T+DNG T + S
Sbjct: 148 QFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSR 207
Query: 336 ------LPIDKRQLYEFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGYDLNK 388
L K YE ++ P L PG I P T + L +++DL PT+ +AG L
Sbjct: 208 GGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGVTHE-LASSLDLLPTLAALAGAPLPN 266
Query: 389 TQMDGMSLLPILRG 402
+DG L P+L G
Sbjct: 267 VTLDGFDLSPLLLG 280
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 51.6 bits (122), Expect = 2e-06
Identities = 99/426 (23%), Positives = 164/426 (38%), Gaps = 91/426 (21%)
Query: 4 LPLAPGRLRRGSPRHL--PSCSPALLLLVLGGCLGVFGVAAGTRRP-NVVLLLTDD---Q 57
LP PG PR L P P LLLL+L G AG RP ++V LL DD
Sbjct: 9 LPRGPG------PRRLLLPVVLPLLLLLLLAPP----GSGAGASRPPHLVFLLADDLGWN 58
Query: 58 DEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHN---HHVVNNTL 114
D G + G+ + Y LC PSR+ +LTG+Y H +
Sbjct: 59 DVGFHGSRIRTPHLDALAAGGVLLDNYYT-QPLCTPSRSQLLTGRYQIRTGLQHQIIWPC 117
Query: 115 EGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGK-YLNEYG---APDAGGLEHVPLGWS 170
+ +C + P +L+ GY T GK +L Y P G + +
Sbjct: 118 QPSCVP------LDEKLLPQLLKE-AGYTTHMVGKWHLGMYRKECLPTRRGFD------T 164
Query: 171 YWYALEKNSKYYNY-------TLSINGKAR--KHGE----NYSVDYLTDVLANVSLDFLD 217
Y+ L + YY++ L++ A + GE Y Y T++ ++ +
Sbjct: 165 YFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALIT 224
Query: 218 YKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPM 277
+P F+ +A + H P +Y K +
Sbjct: 225 NHPPEKPLFLYLALQSVHEPLQVPEEYLKPY----------------------------- 255
Query: 278 TNSSIQFLDNAFRKRWQTLLS-VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHT--GQF 334
F+ + R + ++S +D+ V + L+ +G NNT +++DNG T G
Sbjct: 256 -----DFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGN 310
Query: 335 SLPIDKRQ--LYEFDIKVPLLVRGPGIKPNQT-SKMLVANIDLGPTILDIAGYDLNKTQ- 390
+ P+ R+ L+E ++ V P +K ++ L+ D PT++ +A N T+
Sbjct: 311 NWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKP 370
Query: 391 MDGMSL 396
+DG +
Sbjct: 371 LDGFDV 376
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 51.6 bits (122), Expect = 2e-06
Identities = 99/426 (23%), Positives = 164/426 (38%), Gaps = 91/426 (21%)
Query: 4 LPLAPGRLRRGSPRHL--PSCSPALLLLVLGGCLGVFGVAAGTRRP-NVVLLLTDD---Q 57
LP PG PR L P P LLLL+L G AG RP ++V LL DD
Sbjct: 9 LPRGPG------PRRLLLPVVLPLLLLLLLAPP----GSGAGASRPPHLVFLLADDLGWN 58
Query: 58 DEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHN---HHVVNNTL 114
D G + G+ + Y LC PSR+ +LTG+Y H +
Sbjct: 59 DVGFHGSRIRTPHLDALAAGGVLLDNYYT-QPLCTPSRSQLLTGRYQIRTGLQHQIIWPC 117
Query: 115 EGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGK-YLNEYG---APDAGGLEHVPLGWS 170
+ +C + P +L+ GY T GK +L Y P G + +
Sbjct: 118 QPSCVP------LDEKLLPQLLKE-AGYTTHMVGKWHLGMYRKECLPTRRGFD------T 164
Query: 171 YWYALEKNSKYYNY-------TLSINGKAR--KHGE----NYSVDYLTDVLANVSLDFLD 217
Y+ L + YY++ L++ A + GE Y Y T++ ++ +
Sbjct: 165 YFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALIT 224
Query: 218 YKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPM 277
+P F+ +A + H P +Y K +
Sbjct: 225 NHPPEKPLFLYLALQSVHEPLQVPEEYLKPY----------------------------- 255
Query: 278 TNSSIQFLDNAFRKRWQTLLS-VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHT--GQF 334
F+ + R + ++S +D+ V + L+ +G NNT +++DNG T G
Sbjct: 256 -----DFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGN 310
Query: 335 SLPIDKRQ--LYEFDIKVPLLVRGPGIKPNQT-SKMLVANIDLGPTILDIAGYDLNKTQ- 390
+ P+ R+ L+E ++ V P +K ++ L+ D PT++ +A N T+
Sbjct: 311 NWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKP 370
Query: 391 MDGMSL 396
+DG +
Sbjct: 371 LDGFDV 376
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 49.3 bits (116), Expect = 9e-06
Identities = 76/339 (22%), Positives = 127/339 (37%), Gaps = 48/339 (14%)
Query: 28 LLVLGGCLGVFGVAAGTRRP--------NVVLLLTDDQDEVLGGMTPLKKTKALIGEMG- 78
LL LG L VA G+ NV+L++ DD LG I ++
Sbjct: 10 LLWLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLRPSLGCYGDKLVRSPNIDQLAS 69
Query: 79 --MTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPN--TFPA 134
+ F +A+ A+C PSR S LTG+ P + + S+ ++ N T P
Sbjct: 70 HSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYD--------FNSYWRVHAGNFSTIPQ 121
Query: 135 ILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKARK 194
+ GY T GK + + + P WS+ + KY N
Sbjct: 122 YFKEN-GYVTMSVGKVF--HPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCRGPDGEL 178
Query: 195 HGENYSVDYLTDV---------LANVSLDFLD-YKSNFEPFFMMIATPAPHSPWTAAPQY 244
H + DV ++ L+ K++ PFF+ + PH P+ ++
Sbjct: 179 HANLLCPVDVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEF 238
Query: 245 QKAF--QNV-FAPRNK---NFNIHGTNKHWLIRQAK--------TPMTNSSIQFLDNAFR 290
QK + +N+ AP + N IRQ + P + F +
Sbjct: 239 QKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPVDFQRKIRQ 298
Query: 291 KRWQTLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGY 329
+ ++ +D V +L+ L+ N+T I +TSD+G+
Sbjct: 299 SYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGF 337
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 46.6 bits (109), Expect = 6e-05
Identities = 35/121 (28%), Positives = 61/121 (50%), Gaps = 20/121 (16%)
Query: 299 VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQL--------------- 343
+D +V K++ ++ G NNT +++TSD+G G QL
Sbjct: 318 MDSMVGKILDAIDDFGLRNNTLVYFTSDHG---GHLEARRGHAQLGGWNGIYKGGKGMGG 374
Query: 344 YEFDIKVPLLVRGPGIKP-NQTSKMLVANIDLGPTILDIAGYDLNKTQ-MDGMSLLPILR 401
+E I+VP +VR PG P + K + +D+ PT+ ++G L + + +DG L+P+L+
Sbjct: 375 WEGGIRVPGIVRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQ 434
Query: 402 G 402
G
Sbjct: 435 G 435
Score = 41.6 bits (96), Expect = 0.002
Identities = 36/139 (25%), Positives = 59/139 (42%), Gaps = 11/139 (7%)
Query: 46 RPNVVLLLTDDQD----EVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTG 101
+PN+VL++ DD G T + G+ + ++LC PSR++ LTG
Sbjct: 29 KPNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTG 88
Query: 102 KYPHNHHVV---NNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPD 158
+YP +V N + N + + + E T A+L+ GY T GK+
Sbjct: 89 RYPIRSGMVSSGNRRVIQNLAVPAGLPLNE-TTLAALLKKQ-GYSTGLIGKWHQGLNCDS 146
Query: 159 AGGLEHVP--LGWSYWYAL 175
H P G+ Y+Y +
Sbjct: 147 RSDQCHHPYNYGFDYYYGM 165
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 43.9 bits (102), Expect = 4e-04
Identities = 41/146 (28%), Positives = 60/146 (41%), Gaps = 25/146 (17%)
Query: 46 RPNVVLLLTDDQD----EVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTG 101
RPN++LL+ DD G T + E G+ + ++LC PSRA+ LTG
Sbjct: 37 RPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQHISAASLCTPSRAAFLTG 96
Query: 102 KYPHNHHVVNNTLEGNCSSKSWQKIQ----------EPNTFPAILRSMCGYQTFFAGKYL 151
+YP G SS ++ +Q TF IL+ GY T GK+
Sbjct: 97 RYP--------VRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEK-GYATGLIGKWH 147
Query: 152 NEYGAPDAGGLEHVPL--GWSYWYAL 175
A H PL G+ ++Y +
Sbjct: 148 LGLNCESASDHCHHPLHHGFDHFYGM 173
Score = 43.1 bits (100), Expect = 7e-04
Identities = 33/123 (26%), Positives = 62/123 (50%), Gaps = 20/123 (16%)
Query: 299 VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKRQL--------------- 343
+D +V +++ L+ G N+T I++TSD+G G + Q
Sbjct: 326 MDWMVGRILDTLDVEGLSNSTLIYFTSDHG---GSLENQLGNTQYGGWNGIYKGGKGMGG 382
Query: 344 YEFDIKVPLLVRGPGIKP-NQTSKMLVANIDLGPTILDIAGYDLNKTQ-MDGMSLLPILR 401
+E I+VP + R PG+ P + + +D+ PT++ +AG ++ + + +DG LLP+L
Sbjct: 383 WEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLL 442
Query: 402 GAS 404
G +
Sbjct: 443 GTA 445
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 43.5 bits (101), Expect = 5e-04
Identities = 32/119 (26%), Positives = 64/119 (53%), Gaps = 14/119 (11%)
Query: 299 VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHT----------GQFSLPIDKRQL--YEF 346
+D L+ K++ +E G N+T+ ++TSD+G H G + + + +E
Sbjct: 329 MDWLIGKVLNAIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEG 388
Query: 347 DIKVPLLVRGPGIKP-NQTSKMLVANIDLGPTILDIAGYDLNKTQM-DGMSLLPILRGA 403
I+VP + PG+ P + + +D+ PT++ + G ++ + ++ DG SL+P+L+GA
Sbjct: 389 GIRVPGIFHWPGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVPLLQGA 447
Score = 41.2 bits (95), Expect = 0.002
Identities = 38/144 (26%), Positives = 59/144 (40%), Gaps = 13/144 (9%)
Query: 42 AGTRRPNVVLLLTDDQDE----VLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRAS 97
A +PN++L++ DD G T + E G+ + + LC PSRA+
Sbjct: 36 ANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAA 95
Query: 98 ILTGKYPHNHHVVNN----TLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNE 153
LTG++ + + L+ N S + TF IL+ GY T GK+
Sbjct: 96 FLTGRHSFRSGMDASNGYRALQWNAGSGGLP--ENETTFARILQQH-GYATGLIGKWHQG 152
Query: 154 YGAPDAGGLEHVPL--GWSYWYAL 175
G H PL G+ Y+Y +
Sbjct: 153 VNCASRGDHCHHPLNHGFDYFYGM 176
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 41.2 bits (95), Expect = 0.002
Identities = 38/144 (26%), Positives = 59/144 (40%), Gaps = 13/144 (9%)
Query: 42 AGTRRPNVVLLLTDDQDE----VLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRAS 97
A +PN++L++ DD G T + E G+ + + LC PSRA+
Sbjct: 36 ANAFKPNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAA 95
Query: 98 ILTGKYPHNHHVVNN----TLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNE 153
LTG++ + + L+ N S + TF IL+ GY T GK+
Sbjct: 96 FLTGRHSFRSGMDASNGYRALQWNAGSGGLP--ENETTFARILQQH-GYATGLIGKWHQG 152
Query: 154 YGAPDAGGLEHVPL--GWSYWYAL 175
G H PL G+ Y+Y +
Sbjct: 153 VNCASRGDHCHHPLNHGFDYFYGM 176
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 38.9 bits (89), Expect = 0.012
Identities = 34/125 (27%), Positives = 63/125 (50%), Gaps = 22/125 (17%)
Query: 299 VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLPIDKR-QL-------------- 343
+D +V K++ L+ N+T +++TSDNG H P+D QL
Sbjct: 296 MDWMVGKILDALDQERLANHTLVYFTSDNGGHLE----PLDGAVQLGGWNGIYKGGKGMG 351
Query: 344 -YEFDIKVPLLVRGPGI-KPNQTSKMLVANIDLGPTILDIAGYDLNKTQ-MDGMSLLPIL 400
+E I+VP + R P + + + + +D+ PT+ I G L++ + +DG +L+P+L
Sbjct: 352 GWEGGIRVPGIFRWPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMPLL 411
Query: 401 RGASN 405
G ++
Sbjct: 412 EGRAS 416
Score = 37.4 bits (85), Expect = 0.036
Identities = 39/141 (27%), Positives = 59/141 (41%), Gaps = 14/141 (9%)
Query: 46 RPNVVLLLTDDQDE----VLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTG 101
RPN+VLL+ DD G + + G+ + +++C PSRA+ LTG
Sbjct: 6 RPNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTG 65
Query: 102 KYPHNHHVV---NNTLEGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGKYLNEYGAPD 158
+YP +V N S TF +L+ GY+T GK+ G
Sbjct: 66 RYPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHR-GYRTGLIGKW--HLGLSC 122
Query: 159 AGGLEHV--PL--GWSYWYAL 175
A +H PL G+ Y+Y +
Sbjct: 123 ASRNDHCYHPLNHGFHYFYGV 143
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 33.1 bits (74), Expect = 0.68
Identities = 23/81 (28%), Positives = 35/81 (43%), Gaps = 11/81 (13%)
Query: 79 MTFSSAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQEPN--TFPAIL 136
+ F +A+ A+C PSR S LTG+ P + + S+ ++ N T P
Sbjct: 35 LLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYD--------FNSYWRVHAGNFSTIPQYF 86
Query: 137 RSMCGYQTFFAGKYLNEYGAP 157
+ GY T GK + AP
Sbjct: 87 KEN-GYVTMSVGKVFHPGTAP 106
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.430
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,596,874
Number of Sequences: 37866
Number of extensions: 1026848
Number of successful extensions: 2234
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2120
Number of HSP's gapped (non-prelim): 65
length of query: 552
length of database: 18,247,518
effective HSP length: 107
effective length of query: 445
effective length of database: 14,195,856
effective search space: 6317155920
effective search space used: 6317155920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.