Search of human proteins with 4504031

Search of human proteins with 4504031

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504031 GDP-mannose 4,6-dehydratase [Homo sapiens]
         (372 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504031 GDP-mannose 4,6-dehydratase [Homo sapiens]                 762   0.0  
gi|7657641 TDP-glucose 4,6-dehydratase [Homo sapiens]                  70   3e-12
gi|42516563 UDP-glucuronate decarboxylase 1 [Homo sapiens]             59   7e-09
gi|56118217 UDP-galactose-4-epimerase [Homo sapiens]                   47   4e-05
gi|56237023 UDP-galactose-4-epimerase [Homo sapiens]                   47   4e-05
gi|189083684 UDP-galactose-4-epimerase [Homo sapiens]                  47   4e-05
gi|158631211 transmembrane inner ear protein precursor [Homo sap...    32   0.70 
gi|121583542 mitogen-activated protein kinase kinase kinase 15 [...    31   1.6  
gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Hom...    30   3.5  
gi|122937514 unc-13 homolog C [Homo sapiens]                           30   3.5  

>gi|4504031 GDP-mannose 4,6-dehydratase [Homo sapiens]
          Length = 372

 Score =  762 bits (1968), Expect = 0.0
 Identities = 372/372 (100%), Positives = 372/372 (100%)

Query: 1   MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF 60
           MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF
Sbjct: 1   MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF 60

Query: 61  NTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL 120
           NTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL
Sbjct: 61  NTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDL 120

Query: 121 AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYG 180
           AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYG
Sbjct: 121 AEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYG 180

Query: 181 AAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSL 240
           AAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSL
Sbjct: 181 AAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSL 240

Query: 241 GNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG 300
           GNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG
Sbjct: 241 GNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEG 300

Query: 301 KNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH 360
           KNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH
Sbjct: 301 KNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH 360

Query: 361 ADVELMRTNPNA 372
           ADVELMRTNPNA
Sbjct: 361 ADVELMRTNPNA 372


>gi|7657641 TDP-glucose 4,6-dehydratase [Homo sapiens]
          Length = 350

 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 70/285 (24%), Positives = 127/285 (44%), Gaps = 29/285 (10%)

Query: 79  NMKLHYGDLTDSTCLVKIINEVKPTEIY-NLGAQSHVKISFDLAEYTADVDGVGTLRLLD 137
           N K   GD+ DS   VK++ E +  +I  +  AQ+HV +SF  A     V+  GT  L+ 
Sbjct: 69  NYKFIQGDICDSH-FVKLLFETEKIDIVLHFAAQTHVDLSFVRAFEFTYVNVYGTHVLVS 127

Query: 138 AVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAY 197
           A     +    KF   ST E+YG   +    E++P  P +PY ++K  A   V ++ E Y
Sbjct: 128 AAHEARV---EKFIYVSTDEVYGGSLDKEFDESSPKQPTNPYASSKAAAECFVQSYWEQY 184

Query: 198 NLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVE 257
                  ++    S   G +    K+      +     +C   G+    R++ +A D VE
Sbjct: 185 KF----PVVITRSSNVYGPHQYPEKVIPKFISLLQHNRKCCIHGSGLQTRNFLYATDVVE 240

Query: 258 AMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVW---EGKNENEVGRCKETGK 314
           A   +L+  +P       GE++++    E S + + K ++    E  +E+E+    +   
Sbjct: 241 AFLTVLKKGKP-------GEIYNIGTNFEMSVVQLAKELIQLIKETNSESEMENWVDYVN 293

Query: 315 VHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMV 359
              T D++Y  P + + + G        L W+P+V + E +++ +
Sbjct: 294 DRPTNDMRY--PMKSEKIHG--------LGWRPKVPWKEGIKKTI 328


>gi|42516563 UDP-glucuronate decarboxylase 1 [Homo sapiens]
          Length = 420

 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 81/349 (23%), Positives = 139/349 (39%), Gaps = 54/349 (15%)

Query: 21  KPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGR---IEHLYKNPQAHIE 77
           K R   LITG  G  GS+L + L+  G+EV  +     +F TGR   +EH   +      
Sbjct: 86  KDRKRILITGGAGFVGSHLTDKLMMDGHEVTVV----DNFFTGRKRNVEHWIGHE----- 136

Query: 78  GNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLD 137
            N +L   D+ +          ++  +IY+L + +           T   + +GTL +L 
Sbjct: 137 -NFELINHDVVEPL-------YIEVDQIYHLASPASPPNYMYNPIKTLKTNTIGTLNMLG 188

Query: 138 AVKTCGLINSVKFYQASTSELYGKVQEIPQKE-----TTPFYPRSPYGAAKLYAYWIVVN 192
             K  G     +   ASTSE+YG  +  PQ E       P  PR+ Y   K  A  +   
Sbjct: 189 LAKRVG----ARLLLASTSEVYGDPEVHPQSEDYWGHVNPIGPRACYDEGKRVAETMCYA 244

Query: 193 FREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQ-LECFSLGNLDAKRDWGH 251
           + +   +      +FN   PR   N   R +S  + +   G+ L  +  G+    R + +
Sbjct: 245 YMKQEGVEVRVARIFNTFGPRMHMN-DGRVVSNFILQALQGEPLTVYGSGS--QTRAFQY 301

Query: 252 AKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKE 311
             D V  +  ++ ++      +   E H++ EF +     + K +V  G     +   ++
Sbjct: 302 VSDLVNGLVALMNSNVSSPVNLGNPEEHTILEFAQ-----LIKNLVGSGSEIQFLSEAQD 356

Query: 312 TGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVH 360
                   D +  +P        D  KAK  L W+P V  +E + + +H
Sbjct: 357 --------DPQKRKP--------DIKKAKLMLGWEPVVPLEEGLNKAIH 389


>gi|56118217 UDP-galactose-4-epimerase [Homo sapiens]
          Length = 348

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 67/308 (21%), Positives = 129/308 (41%), Gaps = 31/308 (10%)

Query: 27  LITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF-NTGRIEHLYKNPQAHIEGNMKLHYG 85
           L+TG  G  GS+    LLE GY    I    ++F   G +    +  Q     +++    
Sbjct: 6   LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEM 65

Query: 86  DLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLI 145
           D+ D   L ++  +     + +      V  S         V+  GT++LL+ +K  G+ 
Sbjct: 66  DILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVK 125

Query: 146 NSVKFYQASTSELYGKVQEIPQKETTPFYP-RSPYGAAKLYAYWIVVNFREAYNLFAVNG 204
           N V    +S++ +YG  Q +P  E  P     +PYG +K +   ++ +  +A   +  N 
Sbjct: 126 NLV---FSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW--NA 180

Query: 205 ILFNHESPRRGANF----------VTRKISRSVAKIYLGQLECFSLGNLD-------AKR 247
           +L  + +P  GA+           +   +   V+++ +G+ E  ++   D         R
Sbjct: 181 VLLRYFNP-TGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVR 239

Query: 248 DWGH----AKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWE--GK 301
           D+ H    AK ++ A+  + +      + + TG  +SV + V+      GK I ++   +
Sbjct: 240 DYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVAR 299

Query: 302 NENEVGRC 309
            E +V  C
Sbjct: 300 REGDVAAC 307


>gi|56237023 UDP-galactose-4-epimerase [Homo sapiens]
          Length = 348

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 67/308 (21%), Positives = 129/308 (41%), Gaps = 31/308 (10%)

Query: 27  LITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF-NTGRIEHLYKNPQAHIEGNMKLHYG 85
           L+TG  G  GS+    LLE GY    I    ++F   G +    +  Q     +++    
Sbjct: 6   LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEM 65

Query: 86  DLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLI 145
           D+ D   L ++  +     + +      V  S         V+  GT++LL+ +K  G+ 
Sbjct: 66  DILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVK 125

Query: 146 NSVKFYQASTSELYGKVQEIPQKETTPFYP-RSPYGAAKLYAYWIVVNFREAYNLFAVNG 204
           N V    +S++ +YG  Q +P  E  P     +PYG +K +   ++ +  +A   +  N 
Sbjct: 126 NLV---FSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW--NA 180

Query: 205 ILFNHESPRRGANF----------VTRKISRSVAKIYLGQLECFSLGNLD-------AKR 247
           +L  + +P  GA+           +   +   V+++ +G+ E  ++   D         R
Sbjct: 181 VLLRYFNP-TGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVR 239

Query: 248 DWGH----AKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWE--GK 301
           D+ H    AK ++ A+  + +      + + TG  +SV + V+      GK I ++   +
Sbjct: 240 DYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVAR 299

Query: 302 NENEVGRC 309
            E +V  C
Sbjct: 300 REGDVAAC 307


>gi|189083684 UDP-galactose-4-epimerase [Homo sapiens]
          Length = 348

 Score = 46.6 bits (109), Expect = 4e-05
 Identities = 67/308 (21%), Positives = 129/308 (41%), Gaps = 31/308 (10%)

Query: 27  LITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF-NTGRIEHLYKNPQAHIEGNMKLHYG 85
           L+TG  G  GS+    LLE GY    I    ++F   G +    +  Q     +++    
Sbjct: 6   LVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEM 65

Query: 86  DLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLI 145
           D+ D   L ++  +     + +      V  S         V+  GT++LL+ +K  G+ 
Sbjct: 66  DILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVK 125

Query: 146 NSVKFYQASTSELYGKVQEIPQKETTPFYP-RSPYGAAKLYAYWIVVNFREAYNLFAVNG 204
           N V    +S++ +YG  Q +P  E  P     +PYG +K +   ++ +  +A   +  N 
Sbjct: 126 NLV---FSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTW--NA 180

Query: 205 ILFNHESPRRGANF----------VTRKISRSVAKIYLGQLECFSLGNLD-------AKR 247
           +L  + +P  GA+           +   +   V+++ +G+ E  ++   D         R
Sbjct: 181 VLLRYFNP-TGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVR 239

Query: 248 DWGH----AKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWE--GK 301
           D+ H    AK ++ A+  + +      + + TG  +SV + V+      GK I ++   +
Sbjct: 240 DYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVAR 299

Query: 302 NENEVGRC 309
            E +V  C
Sbjct: 300 REGDVAAC 307


>gi|158631211 transmembrane inner ear protein precursor [Homo
           sapiens]
          Length = 156

 Score = 32.3 bits (72), Expect = 0.70
 Identities = 30/134 (22%), Positives = 54/134 (40%), Gaps = 14/134 (10%)

Query: 158 LYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREA--YNLFAVNGIL-----FNHE 210
           L G   ++ +  T P  P+ P    +   +W +  +     ++LF ++ I+     FN  
Sbjct: 22  LAGVAGQLVEPSTAPPKPKPPPLTKETVVFWDMRLWHVVGIFSLFVLSIIITLCCVFNCR 81

Query: 211 SPRRGANFVTRKISRSVAKIYLGQLECF-------SLGNLDAKRDWGHAKDYVEAMWLML 263
            PR       R + R  AK+Y  +LE          +   D K+     KD V+ + + +
Sbjct: 82  VPRTRKEIEARYLQRKAAKMYTDKLETVPPLNELTEVPGEDKKKKKKKKKDSVDTVAIKV 141

Query: 264 QNDEPEDFVIATGE 277
           + DE  +     GE
Sbjct: 142 EEDEKNEAKKKKGE 155


>gi|121583542 mitogen-activated protein kinase kinase kinase 15
           [Homo sapiens]
          Length = 788

 Score = 31.2 bits (69), Expect = 1.6
 Identities = 25/90 (27%), Positives = 40/90 (44%), Gaps = 1/90 (1%)

Query: 1   MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSF 60
           M  A    P A G G       ++++L  G   Q+ + L E L+EK  E   ++R++   
Sbjct: 627 MDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKEREYQNLLRQTLEQ 686

Query: 61  NTGRIEHLYKNPQAH-IEGNMKLHYGDLTD 89
            T  + HL    +++ I  N    YG  TD
Sbjct: 687 KTQELYHLQLKLKSNCITENPAGPYGQRTD 716


>gi|5174547 mitogen-activated protein kinase kinase kinase 5 [Homo
           sapiens]
          Length = 1374

 Score = 30.0 bits (66), Expect = 3.5
 Identities = 14/48 (29%), Positives = 25/48 (52%)

Query: 74  AHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLA 121
           A I  N+ L Y D+ D   +VK++  ++    ++L +  HVK  +  A
Sbjct: 311 ADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFA 358


>gi|122937514 unc-13 homolog C [Homo sapiens]
          Length = 2214

 Score = 30.0 bits (66), Expect = 3.5
 Identities = 15/48 (31%), Positives = 23/48 (47%)

Query: 111  QSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSEL 158
            Q H  +  DL++Y  +     T RL D   T  L+ S+ F++    EL
Sbjct: 1485 QLHNSLRIDLSKYRENFPASNTERLQDLKSTVDLLTSITFFRMKVLEL 1532


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.136    0.408 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,086,725
Number of Sequences: 37866
Number of extensions: 613793
Number of successful extensions: 1145
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1136
Number of HSP's gapped (non-prelim): 10
length of query: 372
length of database: 18,247,518
effective HSP length: 104
effective length of query: 268
effective length of database: 14,309,454
effective search space: 3834933672
effective search space used: 3834933672
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.