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Search of human proteins with 4503899
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase
precursor [Homo sapiens]
(522 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 1100 0.0
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 268 7e-72
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 268 7e-72
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 268 7e-72
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 268 7e-72
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 245 6e-65
gi|45430057 Arylsulfatase G [Homo sapiens] 245 8e-65
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 181 1e-45
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 176 4e-44
gi|59797060 arylsulfatase family, member I [Homo sapiens] 174 2e-43
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 174 2e-43
gi|58743319 arylsulfatase family, member H [Homo sapiens] 156 5e-38
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 155 6e-38
gi|31742482 arylsulfatase F precursor [Homo sapiens] 153 4e-37
gi|157266309 arylsulfatase E precursor [Homo sapiens] 148 1e-35
gi|109389362 arylsulfatase J [Homo sapiens] 148 1e-35
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 130 2e-30
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 97 5e-20
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 82 1e-15
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 77 5e-14
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 73 7e-13
gi|189571643 sulfatase 1 [Homo sapiens] 68 2e-11
gi|189571641 sulfatase 1 [Homo sapiens] 68 2e-11
gi|189571638 sulfatase 1 [Homo sapiens] 68 2e-11
gi|189571636 sulfatase 1 [Homo sapiens] 68 2e-11
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 65 2e-10
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 65 2e-10
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 65 2e-10
gi|39930577 arylsulfatase K [Homo sapiens] 59 1e-08
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 56 9e-08
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 1100 bits (2846), Expect = 0.0
Identities = 522/522 (100%), Positives = 522/522 (100%)
Query: 1 MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD 60
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD
Sbjct: 1 MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLD 60
Query: 61 RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS 120
RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS
Sbjct: 61 RMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDS 120
Query: 121 EQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPV 180
EQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPV
Sbjct: 121 EQLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPV 180
Query: 181 YRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVY 240
YRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVY
Sbjct: 181 YRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVY 240
Query: 241 ASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQG 300
ASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQG
Sbjct: 241 ASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQG 300
Query: 301 GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSD 360
GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSD
Sbjct: 301 GSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSD 360
Query: 361 RAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCP 420
RAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCP
Sbjct: 361 RAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCP 420
Query: 421 GQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALV 480
GQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALV
Sbjct: 421 GQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQHQEALV 480
Query: 481 PAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH 522
PAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH
Sbjct: 481 PAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH 522
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 268 bits (686), Expect = 7e-72
Identities = 195/533 (36%), Positives = 275/533 (51%), Gaps = 69/533 (12%)
Query: 14 LLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFY 73
LL+ AAG+ + +PPNI+L+ DD+G+GDLG YG PS TPNLD++AA GL F +FY
Sbjct: 7 LLLALAAGLAVA---RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63
Query: 74 SANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGY 133
LC+PSRAALLTGRLP+R G Y P GG+P E + E+L GY
Sbjct: 64 VPVSLCTPSRAALLTGRLPVRMGMYP------GVLVPSSR-GGLPLEEVTVAEVLAARGY 116
Query: 134 VSKIVGKWHLGHRPQ--FHPLKHGFDEWFGSPNCHF-GPYDNKA--RPNIPVYRDWE--- 185
++ + GKWHLG P+ F P GF + G P H GP N P P +
Sbjct: 117 LTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGL 176
Query: 186 -----MVGRYYEEFPINLKTGEANLTQIYLQEALDFIK-RQARHHPFFLYWAVDATHAPV 239
+ E P L EA Y+ A D + Q + PFFLY+A TH P
Sbjct: 177 VPIPLLANLSVEAQPPWLPGLEAR----YMAFAHDLMADAQRQDRPFFLYYASHHTHYPQ 232
Query: 240 YASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ 299
++ + F S RG +GD++ E+D ++G ++ + DL + + T V FT+DNG + +
Sbjct: 233 FSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM-SR 291
Query: 300 GGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPS 359
GG +G CGK TT+EGG+REPALA+WPGH+ G V+H+L S +DL T ALAG P
Sbjct: 292 GGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAG-APLP 349
Query: 360 DRAIDGLNLLPTLL-QGRLMDRPIFYY-------RGDTLMAATLGQHKAHFWTWTNSWEN 411
+ +DG +L P LL G+ + +F+Y RG + A G++KAHF+T S +
Sbjct: 350 NVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRG--VFAVRTGKYKAHFFT-QGSAHS 406
Query: 412 FRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPL----SFASAEYQEALSR 467
C S +T H + PL++ L +DPGE + L + A+ E +AL +
Sbjct: 407 DTTADPACHAS--SSLTAH------EPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
Query: 468 ITSVVQQHQEALV--PAQ------PQLNVCNWAVMNWAPPGCEKLGKCLTPPE 512
+ + Q A+ P+Q P L +C PGC C P+
Sbjct: 459 LQLLKAQLDAAVTFGPSQVARGEDPALQIC-------CHPGCTPRPACCHCPD 504
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 268 bits (686), Expect = 7e-72
Identities = 195/533 (36%), Positives = 275/533 (51%), Gaps = 69/533 (12%)
Query: 14 LLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFY 73
LL+ AAG+ + +PPNI+L+ DD+G+GDLG YG PS TPNLD++AA GL F +FY
Sbjct: 7 LLLALAAGLAVA---RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63
Query: 74 SANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGY 133
LC+PSRAALLTGRLP+R G Y P GG+P E + E+L GY
Sbjct: 64 VPVSLCTPSRAALLTGRLPVRMGMYP------GVLVPSSR-GGLPLEEVTVAEVLAARGY 116
Query: 134 VSKIVGKWHLGHRPQ--FHPLKHGFDEWFGSPNCHF-GPYDNKA--RPNIPVYRDWE--- 185
++ + GKWHLG P+ F P GF + G P H GP N P P +
Sbjct: 117 LTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGL 176
Query: 186 -----MVGRYYEEFPINLKTGEANLTQIYLQEALDFIK-RQARHHPFFLYWAVDATHAPV 239
+ E P L EA Y+ A D + Q + PFFLY+A TH P
Sbjct: 177 VPIPLLANLSVEAQPPWLPGLEAR----YMAFAHDLMADAQRQDRPFFLYYASHHTHYPQ 232
Query: 240 YASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ 299
++ + F S RG +GD++ E+D ++G ++ + DL + + T V FT+DNG + +
Sbjct: 233 FSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM-SR 291
Query: 300 GGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPS 359
GG +G CGK TT+EGG+REPALA+WPGH+ G V+H+L S +DL T ALAG P
Sbjct: 292 GGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAG-APLP 349
Query: 360 DRAIDGLNLLPTLL-QGRLMDRPIFYY-------RGDTLMAATLGQHKAHFWTWTNSWEN 411
+ +DG +L P LL G+ + +F+Y RG + A G++KAHF+T S +
Sbjct: 350 NVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRG--VFAVRTGKYKAHFFT-QGSAHS 406
Query: 412 FRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPL----SFASAEYQEALSR 467
C S +T H + PL++ L +DPGE + L + A+ E +AL +
Sbjct: 407 DTTADPACHAS--SSLTAH------EPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
Query: 468 ITSVVQQHQEALV--PAQ------PQLNVCNWAVMNWAPPGCEKLGKCLTPPE 512
+ + Q A+ P+Q P L +C PGC C P+
Sbjct: 459 LQLLKAQLDAAVTFGPSQVARGEDPALQIC-------CHPGCTPRPACCHCPD 504
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 268 bits (686), Expect = 7e-72
Identities = 195/533 (36%), Positives = 275/533 (51%), Gaps = 69/533 (12%)
Query: 14 LLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFY 73
LL+ AAG+ + +PPNI+L+ DD+G+GDLG YG PS TPNLD++AA GL F +FY
Sbjct: 7 LLLALAAGLAVA---RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63
Query: 74 SANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGY 133
LC+PSRAALLTGRLP+R G Y P GG+P E + E+L GY
Sbjct: 64 VPVSLCTPSRAALLTGRLPVRMGMYP------GVLVPSSR-GGLPLEEVTVAEVLAARGY 116
Query: 134 VSKIVGKWHLGHRPQ--FHPLKHGFDEWFGSPNCHF-GPYDNKA--RPNIPVYRDWE--- 185
++ + GKWHLG P+ F P GF + G P H GP N P P +
Sbjct: 117 LTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGL 176
Query: 186 -----MVGRYYEEFPINLKTGEANLTQIYLQEALDFIK-RQARHHPFFLYWAVDATHAPV 239
+ E P L EA Y+ A D + Q + PFFLY+A TH P
Sbjct: 177 VPIPLLANLSVEAQPPWLPGLEAR----YMAFAHDLMADAQRQDRPFFLYYASHHTHYPQ 232
Query: 240 YASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ 299
++ + F S RG +GD++ E+D ++G ++ + DL + + T V FT+DNG + +
Sbjct: 233 FSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM-SR 291
Query: 300 GGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPS 359
GG +G CGK TT+EGG+REPALA+WPGH+ G V+H+L S +DL T ALAG P
Sbjct: 292 GGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAG-APLP 349
Query: 360 DRAIDGLNLLPTLL-QGRLMDRPIFYY-------RGDTLMAATLGQHKAHFWTWTNSWEN 411
+ +DG +L P LL G+ + +F+Y RG + A G++KAHF+T S +
Sbjct: 350 NVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRG--VFAVRTGKYKAHFFT-QGSAHS 406
Query: 412 FRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPL----SFASAEYQEALSR 467
C S +T H + PL++ L +DPGE + L + A+ E +AL +
Sbjct: 407 DTTADPACHAS--SSLTAH------EPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
Query: 468 ITSVVQQHQEALV--PAQ------PQLNVCNWAVMNWAPPGCEKLGKCLTPPE 512
+ + Q A+ P+Q P L +C PGC C P+
Sbjct: 459 LQLLKAQLDAAVTFGPSQVARGEDPALQIC-------CHPGCTPRPACCHCPD 504
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 268 bits (686), Expect = 7e-72
Identities = 195/533 (36%), Positives = 275/533 (51%), Gaps = 69/533 (12%)
Query: 14 LLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFY 73
LL+ AAG+ + +PPNI+L+ DD+G+GDLG YG PS TPNLD++AA GL F +FY
Sbjct: 7 LLLALAAGLAVA---RPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFY 63
Query: 74 SANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGY 133
LC+PSRAALLTGRLP+R G Y P GG+P E + E+L GY
Sbjct: 64 VPVSLCTPSRAALLTGRLPVRMGMYP------GVLVPSSR-GGLPLEEVTVAEVLAARGY 116
Query: 134 VSKIVGKWHLGHRPQ--FHPLKHGFDEWFGSPNCHF-GPYDNKA--RPNIPVYRDWE--- 185
++ + GKWHLG P+ F P GF + G P H GP N P P +
Sbjct: 117 LTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQNLTCFPPATPCDGGCDQGL 176
Query: 186 -----MVGRYYEEFPINLKTGEANLTQIYLQEALDFIK-RQARHHPFFLYWAVDATHAPV 239
+ E P L EA Y+ A D + Q + PFFLY+A TH P
Sbjct: 177 VPIPLLANLSVEAQPPWLPGLEAR----YMAFAHDLMADAQRQDRPFFLYYASHHTHYPQ 232
Query: 240 YASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ 299
++ + F S RG +GD++ E+D ++G ++ + DL + + T V FT+DNG + +
Sbjct: 233 FSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM-SR 291
Query: 300 GGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPS 359
GG +G CGK TT+EGG+REPALA+WPGH+ G V+H+L S +DL T ALAG P
Sbjct: 292 GGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELASSLDLLPTLAALAG-APLP 349
Query: 360 DRAIDGLNLLPTLL-QGRLMDRPIFYY-------RGDTLMAATLGQHKAHFWTWTNSWEN 411
+ +DG +L P LL G+ + +F+Y RG + A G++KAHF+T S +
Sbjct: 350 NVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRG--VFAVRTGKYKAHFFT-QGSAHS 406
Query: 412 FRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPL----SFASAEYQEALSR 467
C S +T H + PL++ L +DPGE + L + A+ E +AL +
Sbjct: 407 DTTADPACHAS--SSLTAH------EPPLLYDLSKDPGENYNLLGGVAGATPEVLQALKQ 458
Query: 468 ITSVVQQHQEALV--PAQ------PQLNVCNWAVMNWAPPGCEKLGKCLTPPE 512
+ + Q A+ P+Q P L +C PGC C P+
Sbjct: 459 LQLLKAQLDAAVTFGPSQVARGEDPALQIC-------CHPGCTPRPACCHCPD 504
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 245 bits (626), Expect = 6e-65
Identities = 174/547 (31%), Positives = 261/547 (47%), Gaps = 74/547 (13%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR 90
PNILL++ DD+G GDLG YG + TPN+D++A EG+ +A PLC+PSRAA LTGR
Sbjct: 41 PNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGR 100
Query: 91 LPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ-- 148
R+G +N + + GG+P++E +L++ GY + ++GKWH G
Sbjct: 101 HSFRSGMDASNGYRALQWNAGS--GGLPENETTFARILQQHGYATGLIGKWHQGVNCASR 158
Query: 149 ----FHPLKHGFDEWFGSP-----NCHFG---PYDNKARPNIPVYRDWEMVG-------- 188
HPL HGFD ++G P +C G D R + Y + +G
Sbjct: 159 GDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQ 218
Query: 189 ------------------------RYYEEFP-------INLKTGEANLTQIYLQEALDFI 217
+Y F I ++ + + L++ +
Sbjct: 219 TCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLM 278
Query: 218 KRQA-------RHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILE 270
++A +H PF L+ ++ H P+ + FLG SQ G YGD V E+D IGK+L
Sbjct: 279 LKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMDWLIGKVLN 338
Query: 271 LLQDLHVADNTFVFFTSDNGAALISA---PEQGGSNGPFLCGK-QTTFEGGMREPALAWW 326
++D + ++TF +FTSD+G L + + GG NG + GK +EGG+R P + W
Sbjct: 339 AIEDNGLKNSTFTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHW 398
Query: 327 PGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQG---RLMDRPIF 383
PG + AG+V + S+MD+F T + L G P DR IDG +L+P LLQG R +F
Sbjct: 399 PGVLPAGRVIGEPTSLMDVFPTVVQLVGGEVPQDRVIDGHSLVP-LLQGAEARSAHEFLF 457
Query: 384 YYRGDTLMAATLGQ-HKAHFWTWTNSWENFR-QGIDFCPGQNVSGVTTHNLEDHTKLPLI 441
+Y G L AA Q W + F +G C G+ V + + H + PL+
Sbjct: 458 HYCGQHLHAARWHQKDSGSVWKVHYTTPQFHPEGAGACYGRGVCPCSGEGVTHH-RPPLL 516
Query: 442 FHLGRDPGERFPLSFASAE-YQEALSRITSVVQQHQEALVPAQPQLNVCNWAVMNWAPPG 500
F L RDP E PL+ S Y ++R+ + V +H++ L P Q ++ N W P
Sbjct: 517 FDLSRDPSEARPLTPDSEPLYHAVIARVGAAVSEHRQTLSPVPQQFSMSNILWKPWLQPC 576
Query: 501 CEKLGKC 507
C C
Sbjct: 577 CGHFPFC 583
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 245 bits (625), Expect = 8e-65
Identities = 176/490 (35%), Positives = 244/490 (49%), Gaps = 83/490 (16%)
Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88
Q PN +++L DDMGWGDLG +++T NLD+MA+EG+ F +F++A CSPSRA+LLT
Sbjct: 34 QKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPSRASLLT 93
Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148
GRL +RNG T N + VGG+P +E L E+L++AGYV+ I+GKWHLGH
Sbjct: 94 GRLGLRNG-VTRNFAVTS-------VGGLPLNETTLAEVLQQAGYVTGIIGKWHLGHHGS 145
Query: 149 FHPLKHGFDEWFGSPNCH---------------------FGPYDNKARP-----NIPVYR 182
+HP GFD +FG P H GP N R +P+Y
Sbjct: 146 YHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYE 205
Query: 183 DWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARH-HPFFLYWAVDATHAPVYA 241
+ +V E P+NL ++L Q Y ++A FI+R + PF LY A+ H P+
Sbjct: 206 NLNIV-----EQPVNL----SSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPV 256
Query: 242 SKPFLGTSQRGR--YGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ 299
++ L + RGR YG + E+D +G+I + + D V +NTF++FT DNG E
Sbjct: 257 TQ--LPAAPRGRSLYGAGLWEMDSLVGQIKDKV-DHTVKENTFLWFTGDNG-PWAQKCEL 312
Query: 300 GGSNGPFL----------CGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTS 349
GS GPF KQTT+EGG R PALA+WPG V S L S++D+F T
Sbjct: 313 AGSVGPFTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTV 372
Query: 350 LALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGD-------TLMAATLGQHKAHF 402
+ALA + P R DG+++ L + ++ L L ++KA +
Sbjct: 373 VALAQASLPQGRRFDGVDVSEVLFGRSQPGHRVLFHPNSGAAGEFGALQTVRLERYKAFY 432
Query: 403 WTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQ 462
T G C G E K PLIF+L D E PL AEYQ
Sbjct: 433 IT---------GGARACDGST-------GPELQHKFPLIFNLEDDTAEAVPLERGGAEYQ 476
Query: 463 EALSRITSVV 472
L + V+
Sbjct: 477 AVLPEVRKVL 486
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 181 bits (459), Expect = 1e-45
Identities = 144/432 (33%), Positives = 211/432 (48%), Gaps = 59/432 (13%)
Query: 115 GGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ--FHPLKHGFDEWFGSPNCHF-GPYD 171
GG+P E + E+L GY++ + GKWHLG P+ F P GF + G P H GP
Sbjct: 14 GGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFLGIPYSHDQGPCQ 73
Query: 172 NKA--RPNIPVYRDWE--------MVGRYYEEFPINLKTGEANLTQIYLQEALDFIK-RQ 220
N P P + + E P L EA Y+ A D + Q
Sbjct: 74 NLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEAR----YMAFAHDLMADAQ 129
Query: 221 ARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADN 280
+ PFFLY+A TH P ++ + F S RG +GD++ E+D ++G ++ + DL + +
Sbjct: 130 RQDRPFFLYYASHHTHYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEE 189
Query: 281 TFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLG 340
T V FT+DNG + +GG +G CGK TT+EGG+REPALA+WPGH+ G V+H+L
Sbjct: 190 TLVIFTADNGPETMRM-SRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPG-VTHELA 247
Query: 341 SIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLL-QGRLMDRPIFYY-------RGDTLMA 392
S +DL T ALAG P + +DG +L P LL G+ + +F+Y RG + A
Sbjct: 248 SSLDLLPTLAALAG-APLPNVTLDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRG--VFA 304
Query: 393 ATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERF 452
G++KAHF+T S + C S +T H + PL++ L +DPGE +
Sbjct: 305 VRTGKYKAHFFT-QGSAHSDTTADPACHAS--SSLTAH------EPPLLYDLSKDPGENY 355
Query: 453 PL----SFASAEYQEALSRITSVVQQHQEALV--PAQ------PQLNVCNWAVMNWAPPG 500
L + A+ E +AL ++ + Q A+ P+Q P L +C PG
Sbjct: 356 NLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQIC-------CHPG 408
Query: 501 CEKLGKCLTPPE 512
C C P+
Sbjct: 409 CTPRPACCHCPD 420
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 176 bits (447), Expect = 4e-44
Identities = 157/516 (30%), Positives = 238/516 (46%), Gaps = 79/516 (15%)
Query: 13 LLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNF 72
LLL+L+ G GA GA +PP+++ LL DD+GW D+G +G R TP+LD +AA G+L N+
Sbjct: 28 LLLLLAPPGSGA-GASRPPHLVFLLADDLGWNDVGFHGSRIR-TPHLDALAAGGVLLDNY 85
Query: 73 YSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAG 132
Y+ PLC+PSR+ LLTGR IR G P + +P E+LLP+LLK+AG
Sbjct: 86 YT-QPLCTPSRSQLLTGRYQIRTGLQ------HQIIWPCQ-PSCVPLDEKLLPQLLKEAG 137
Query: 133 YVSKIVGKWHLG-HRPQFHPLKHGFDEWFG----------SPNCHFGPYDNKARPNIPVY 181
Y + +VGKWHLG +R + P + GFD +FG C N R + +
Sbjct: 138 YTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALD-F 196
Query: 182 RDWEMVGRYYEEFPINLKTGEANL--TQIYLQEALDFIKRQARHHPFFLYWAVDATHAPV 239
RD E V TG N+ T I+ + A+ I P FLY A+ + H P+
Sbjct: 197 RDGEEVA-----------TGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPL 245
Query: 240 YAS----KP--FLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAAL 293
KP F+ R Y V +D+++G + L+ + +NT F++DNG
Sbjct: 246 QVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQT 305
Query: 294 ISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALA 353
++ GG+N P K + +EGG+R P G + +L I D T + LA
Sbjct: 306 LA----GGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLA 361
Query: 354 GLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMA----------------ATLGQ 397
+ +DG ++ T+ +G R + D ++L +
Sbjct: 362 RGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPE 421
Query: 398 HKA-----HFWTWTNSWENFRQGIDFC------PGQ-NVSGVTTHNLEDHTKLPLIFHLG 445
+ A H +W+ G C P Q NVS + + + TK +F +
Sbjct: 422 YSAFNTSVHAAIRHGNWK-LLTGYPGCGYWFPPPSQYNVSEIPSS--DPPTKTLWLFDID 478
Query: 446 RDPGERFPLSFASAEYQEALSRITSVVQQHQEALVP 481
RDP ER L S EY ++++ S +Q + + VP
Sbjct: 479 RDPEERHDL---SREYPHIVTKLLSRLQFYHKHSVP 511
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 174 bits (441), Expect = 2e-43
Identities = 126/402 (31%), Positives = 190/402 (47%), Gaps = 44/402 (10%)
Query: 24 ASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSR 83
++ PQPP+I+ +L DD G+ D+G +G ETP LDR+AA+G+ N+Y P+C+PSR
Sbjct: 40 SAAPPQPPHIIFILTDDQGYHDVGYHGSDI-ETPTLDRLAAKGVKLENYY-IQPICTPSR 97
Query: 84 AALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHL 143
+ LLTGR I G + PQ+ +P + LP+ L++AGY + +VGKWHL
Sbjct: 98 SQLLTGRYQIHTGLQ------HSIIRPQQ-PNCLPLDQVTLPQKLQEAGYSTHMVGKWHL 150
Query: 144 G-HRPQFHPLKHGFDEWFGS--PNCHFGPYDNKARPNIPVYR-------DWEMVGRYYEE 193
G +R + P + GFD + GS N + YDN P + + W + G+Y
Sbjct: 151 GFYRKECLPTRRGFDTFLGSLTGNVDYYTYDNCDGPGVCGFDLHEGENVAWGLSGQY--- 207
Query: 194 FPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFL------G 247
T +Y Q A + + P FLY A A H P+ + + +L G
Sbjct: 208 -----------STMLYAQRASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMG 256
Query: 248 TSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFL 307
R +Y V +D+++ I L+ +N+ + F+SDNG S GGSN P
Sbjct: 257 NVARRKYAAMVTCMDEAVRNITWALKRYGFYNNSVIIFSSDNGGQTFS----GGSNWPLR 312
Query: 308 CGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLN 367
K T +EGG+R P + S L I D + T + LAG T + +DG +
Sbjct: 313 GRKGTYWEGGVRGLGFVHSPLLKRKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYD 372
Query: 368 LLPTLLQGRLMDRPIFYYRGDTLM-AATLGQHKAHFWTWTNS 408
+ P + +GR R + D L A G + F W +
Sbjct: 373 VWPAISEGRASPRTEILHNIDPLYNHAQHGSLEGGFGIWNTA 414
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 174 bits (440), Expect = 2e-43
Identities = 128/382 (33%), Positives = 190/382 (49%), Gaps = 45/382 (11%)
Query: 13 LLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNF 72
LLL+L+ G GA GA +PP+++ LL DD+GW D+G +G R TP+LD +AA G+L N+
Sbjct: 28 LLLLLAPPGSGA-GASRPPHLVFLLADDLGWNDVGFHGSRIR-TPHLDALAAGGVLLDNY 85
Query: 73 YSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAG 132
Y+ PLC+PSR+ LLTGR IR G P + +P E+LLP+LLK+AG
Sbjct: 86 YT-QPLCTPSRSQLLTGRYQIRTGLQ------HQIIWPCQ-PSCVPLDEKLLPQLLKEAG 137
Query: 133 YVSKIVGKWHLG-HRPQFHPLKHGFDEWFG----------SPNCHFGPYDNKARPNIPVY 181
Y + +VGKWHLG +R + P + GFD +FG C N R + +
Sbjct: 138 YTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALD-F 196
Query: 182 RDWEMVGRYYEEFPINLKTGEANL--TQIYLQEALDFIKRQARHHPFFLYWAVDATHAPV 239
RD E V TG N+ T I+ + A+ I P FLY A+ + H P+
Sbjct: 197 RDGEEVA-----------TGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPL 245
Query: 240 YAS----KP--FLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAAL 293
KP F+ R Y V +D+++G + L+ + +NT F++DNG
Sbjct: 246 QVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQT 305
Query: 294 ISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALA 353
++ GG+N P K + +EGG+R P G + +L I D T + LA
Sbjct: 306 LA----GGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLA 361
Query: 354 GLTPPSDRAIDGLNLLPTLLQG 375
+ +DG ++ T+ +G
Sbjct: 362 RGHTNGTKPLDGFDVWKTISEG 383
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 156 bits (394), Expect = 5e-38
Identities = 109/323 (33%), Positives = 165/323 (51%), Gaps = 28/323 (8%)
Query: 202 EANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREI 261
E + + L+EAL FI+R R PF L+++ H P+ + K F+G S+ GRYGD V E+
Sbjct: 238 EEKVASLMLKEALAFIERYKRE-PFLLFFSFLHVHTPLISKKKFVGRSKYGRYGDNVEEM 296
Query: 262 DDSIGKILELLQDLHVADNTFVFFTSDNGA---ALISAPEQGGSNGPFLCGK-QTTFEGG 317
D +GKIL+ L +A++T V+FTSDNG L A + GG NG + GK +EGG
Sbjct: 297 DWMVGKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGGWNGIYKGGKGMGGWEGG 356
Query: 318 MREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRL 377
+R P + WP + AG+V ++ S+MD++ T + G DR IDG NL+P LL+GR
Sbjct: 357 IRVPGIFRWPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQDRVIDGQNLMP-LLEGRA 415
Query: 378 MDRP---IFYYRGDTLMAATLGQH------KAHFWTWTNSWENFRQGIDFCPGQNV---S 425
+F+Y G L Q KAH+ T + + +G C G + S
Sbjct: 416 SHSDHEFLFHYCGVYLHTVRWHQKDCATVWKAHYVT----PKFYPEGTGACYGSGICSCS 471
Query: 426 GVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAE-YQEALSRITSVVQQHQEALVPAQP 484
G T++ PL+F + RDP E PL+ + + + ++ + +++H+ L P
Sbjct: 472 GDVTYH-----DPPLLFDISRDPSEALPLNPDNEPLFDSVIKKMEAAIREHRRTLTPVPQ 526
Query: 485 QLNVCNWAVMNWAPPGCEKLGKC 507
Q +V N W P C C
Sbjct: 527 QFSVFNTIWKPWLQPCCGTFPFC 549
Score = 117 bits (294), Expect = 2e-26
Identities = 65/160 (40%), Positives = 91/160 (56%), Gaps = 10/160 (6%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR 90
PNI+LL+ DD+G GDL YG S TPN+DR+A+EG+ +A +C+PSRAA LTGR
Sbjct: 7 PNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTGR 66
Query: 91 LPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG------ 144
PIR+G + + A+T GG+P +E +LL+ GY + ++GKWHLG
Sbjct: 67 YPIRSGMVSA-YNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCASR 125
Query: 145 HRPQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDW 184
+ +HPL HGF ++G P FG + P W
Sbjct: 126 NDHCYHPLNHGFHYFYGVP---FGLLSDCQASKTPELHRW 162
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 155 bits (393), Expect = 6e-38
Identities = 111/316 (35%), Positives = 156/316 (49%), Gaps = 21/316 (6%)
Query: 204 NLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDD 263
NLTQ EA FI+R PF L + H +++SK F G SQ G YGDAV E+D
Sbjct: 259 NLTQRLTVEAAQFIQRNTET-PFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDW 317
Query: 264 SIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQ----GGSNGPFLCGKQTTFEGGMR 319
S+G+IL LL +L +A++T ++FTSD GA + + GGSNG + GK +EGG+R
Sbjct: 318 SVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIR 377
Query: 320 EPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMD 379
P + WP + AGQ + S MD+F T LAG P DR IDG +L+P LL+G+
Sbjct: 378 VPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMP-LLEGKSQR 436
Query: 380 RP---IFYYRGDTLMAATLGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTH------ 430
+F+Y A L + H T+ W+ F +F P + TH
Sbjct: 437 SDHEFLFHY-----CNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFG 491
Query: 431 NLEDHTKLPLIFHLGRDPGERFPLSFAS-AEYQEALSRITSVVQQHQEALVPAQPQLNVC 489
+ H PL+F + +DP ER PL+ AS + E L + +H + L Q +
Sbjct: 492 SYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWN 551
Query: 490 NWAVMNWAPPGCEKLG 505
N+ W C G
Sbjct: 552 NFLWKPWLQLCCPSTG 567
Score = 117 bits (292), Expect = 3e-26
Identities = 60/143 (41%), Positives = 87/143 (60%), Gaps = 8/143 (5%)
Query: 25 SGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRA 84
S A PNI+L++ DD+G GD G YG + TPN+DR+A+ G+ +A+PLC+PSRA
Sbjct: 21 SHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRA 80
Query: 85 ALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG 144
A +TGR P+R+G + + +T GG+P E +LLK GY + ++GKWHLG
Sbjct: 81 AFMTGRYPVRSGMASWSRTGVFLFTASS--GGLPTDEITFAKLLKDQGYSTALIGKWHLG 138
Query: 145 ----HRPQF--HPLKHGFDEWFG 161
+ F HPL HGF+ ++G
Sbjct: 139 MSCHSKTDFCHHPLHHGFNYFYG 161
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 153 bits (386), Expect = 4e-37
Identities = 109/324 (33%), Positives = 168/324 (51%), Gaps = 31/324 (9%)
Query: 208 IYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSIGK 267
I ++EA+ F++R ++ F L+++ H P+ + F GTS+ G YGD V E+D +GK
Sbjct: 266 IMVKEAISFLERHSKE-TFLLFFSFLHVHTPLPTTDDFTGTSKHGLYGDNVEEMDSMVGK 324
Query: 268 ILELLQDLHVADNTFVFFTSDNGAALISA---PEQGGSNGPFLCGK-QTTFEGGMREPAL 323
IL+ + D + +NT V+FTSD+G L + + GG NG + GK +EGG+R P +
Sbjct: 325 ILDAIDDFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGI 384
Query: 324 AWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRP-- 381
WPG V AG++ + S+MD+ T +++G + P DR IDG +L+P LLQG +
Sbjct: 385 VRWPGKVPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMP-LLQGNVRHSEHE 443
Query: 382 -IFYYRGDTLMAA-------TLGQHKAHFWTWT----NSWENFRQGIDFCPGQNVSGVTT 429
+F+Y G L A + KAH+ T S + + C G+ VT
Sbjct: 444 FLFHYCGSYLHAVRWIPKDDSGSVWKAHYVTPVFQPPASGGCYVTSLCRCFGEQ---VTY 500
Query: 430 HNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQE-ALSRITSVVQQHQEALVPAQPQLNV 488
HN PL+F L RDP E PL+ A+ + + ++ + +++HQE +VP QL+
Sbjct: 501 HN------PPLLFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVTYQLSE 554
Query: 489 CNWAVMNWAPPGCEKLGKCLTPPE 512
N W P C CL E
Sbjct: 555 LNQG-RTWLKPCCGVFPFCLCDKE 577
Score = 117 bits (293), Expect = 3e-26
Identities = 60/139 (43%), Positives = 83/139 (59%), Gaps = 8/139 (5%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR 90
PNI+L+++DD+G GDLG YG + TP++DR+A EG+ SA LCSPSR+A LTGR
Sbjct: 30 PNIVLIMVDDLGIGDLGCYGNDTMRTPHIDRLAREGVRLTQHISAASLCSPSRSAFLTGR 89
Query: 91 LPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ-- 148
PIR+G ++ R + G+P +E L LLKK GY + ++GKWH G
Sbjct: 90 YPIRSGMVSSG--NRRVIQNLAVPAGLPLNETTLAALLKKQGYSTGLIGKWHQGLNCDSR 147
Query: 149 ----FHPLKHGFDEWFGSP 163
HP +GFD ++G P
Sbjct: 148 SDQCHHPYNYGFDYYYGMP 166
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 148 bits (374), Expect = 1e-35
Identities = 112/324 (34%), Positives = 158/324 (48%), Gaps = 19/324 (5%)
Query: 206 TQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREIDDSI 265
T + LQE F+KR +H PF L+ + H P+ + FLG S G YGD V E+D +
Sbjct: 272 TPLILQEVASFLKRN-KHGPFLLFVSFLHVHIPLITMENFLGKSLHGLYGDNVEEMDWMV 330
Query: 266 GKILELLQDLHVADNTFVFFTSDNGAAL---ISAPEQGGSNGPFLCGK-QTTFEGGMREP 321
G+IL+ L ++++T ++FTSD+G +L + + GG NG + GK +EGG+R P
Sbjct: 331 GRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGKGMGGWEGGIRVP 390
Query: 322 ALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLL-QGRLMDR 380
+ WPG + AG+V + S+MD+F T + LAG P DR IDG +LLP LL + D
Sbjct: 391 GIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLLPLLLGTAQHSDH 450
Query: 381 P-IFYYRGDTLMAATLGQH------KAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLE 433
+ +Y L AA Q K HF T E G C G+ V +
Sbjct: 451 EFLMHYCERFLHAARWHQRDRGTMWKVHFVTPVFQPE----GAGACYGRKVCPCFGEKVV 506
Query: 434 DHTKLPLIFHLGRDPGERFPLSFASAE-YQEALSRITSVVQQHQEALVPAQPQLNVCNWA 492
H PL+F L RDP E L+ AS + + + R+ V +HQ L P QL+
Sbjct: 507 HHDP-PLLFDLSRDPSETHILTPASEPVFYQVMERVQQAVWEHQRTLSPVPLQLDRLGNI 565
Query: 493 VMNWAPPGCEKLGKCLTPPESIPK 516
W P C C E P+
Sbjct: 566 WRPWLQPCCGPFPLCWCLREDDPQ 589
Score = 126 bits (317), Expect = 4e-29
Identities = 66/158 (41%), Positives = 96/158 (60%), Gaps = 9/158 (5%)
Query: 13 LLLVLSAAGMGASG-APQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPN 71
L ++LS A +S + PNILLL+ DD+G GD+G YG + TPN+DR+A +G+
Sbjct: 19 LAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQ 78
Query: 72 FYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKA 131
SA LC+PSRAA LTGR P+R+G ++ + +T GG+P +E ++LK+
Sbjct: 79 HISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGAS--GGLPTNETTFAKILKEK 136
Query: 132 GYVSKIVGKWHLGHRPQ------FHPLKHGFDEWFGSP 163
GY + ++GKWHLG + HPL HGFD ++G P
Sbjct: 137 GYATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMP 174
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 148 bits (373), Expect = 1e-35
Identities = 128/488 (26%), Positives = 208/488 (42%), Gaps = 64/488 (13%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR 90
P+++ +L DD G+ D+G +G + TP LD++AAEG+ N+Y P+C+PSR+ +TG+
Sbjct: 76 PHLIFILADDQGFRDVGYHGSEIK-TPTLDKLAAEGVKLENYY-VQPICTPSRSQFITGK 133
Query: 91 LPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLG-HRPQF 149
I G + P + +P LP+ LK+ GY + +VGKWHLG +R +
Sbjct: 134 YQIHTGLQ------HSIIRPTQ-PNCLPLDNATLPQKLKEVGYSTHMVGKWHLGFYRKEC 186
Query: 150 HPLKHGFDEWFGS---PNCHFGPY--DNKARPNIPVYRD----WEMVGRYYEEFPINLKT 200
P + GFD +FGS ++ Y D+ +Y + W+ Y
Sbjct: 187 MPTRRGFDTFFGSLLGSGDYYTHYKCDSPGMCGYDLYENDNAAWDYDNGIYS-------- 238
Query: 201 GEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATHAPVYASKPFLG------TSQRGRY 254
TQ+Y Q + P FLY A A H+P+ A + R RY
Sbjct: 239 -----TQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRY 293
Query: 255 GDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTF 314
+ +D++I + L+ +N+ + ++SDNG P GGSN P K T +
Sbjct: 294 AAMLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQ----PTAGGSNWPLRGSKGTYW 349
Query: 315 EGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQ 374
EGG+R P G V +L I D + T ++LA D +DG ++ T+ +
Sbjct: 350 EGGIRAVGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISE 409
Query: 375 GRLMDRPIFYYRGDTLMA-ATLGQHKAHFWTWTNS---------WENFRQG---IDFCPG 421
G R + D + A G A + W + W+ D+ P
Sbjct: 410 GLRSPRVDILHNIDPIYTKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYSDWVPP 469
Query: 422 QNVSGVTTHNLEDHT------KLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQH 475
Q+ S + + + K +F++ DP ER L S Y + ++ + Q
Sbjct: 470 QSFSNLGPNRWHNERITLSTGKSVWLFNITADPYERVDL---SNRYPGIVKKLLRRLSQF 526
Query: 476 QEALVPAQ 483
+ VP +
Sbjct: 527 NKTAVPVR 534
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 130 bits (328), Expect = 2e-30
Identities = 87/292 (29%), Positives = 133/292 (45%), Gaps = 62/292 (21%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGR 90
PNILL++ DD+G GDLG YG + TPN+D++A EG+ +A PLC+PSRAA LTGR
Sbjct: 41 PNILLIMADDLGTGDLGCYGNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGR 100
Query: 91 LPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ-- 148
R+G +N + + GG+P++E +L++ GY + ++GKWH G
Sbjct: 101 HSFRSGMDASNGYRALQWNAGS--GGLPENETTFARILQQHGYATGLIGKWHQGVNCASR 158
Query: 149 ----FHPLKHGFDEWFGSP-----NCHFG---PYDNKARPNIPVYRDWEMVG-------- 188
HPL HGFD ++G P +C G D R + Y + +G
Sbjct: 159 GDHCHHPLNHGFDYFYGMPFTLTNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQ 218
Query: 189 ------------------------RYYEEFP-------INLKTGEANLTQIYLQEALDFI 217
+Y F I ++ + + L++ +
Sbjct: 219 TCGFFSVSARAVTGMAGVGCLFFISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLM 278
Query: 218 KRQA-------RHHPFFLYWAVDATHAPVYASKPFLGTSQRGRYGDAVREID 262
++A +H PF L+ ++ H P+ + FLG SQ G YGD V E+D
Sbjct: 279 LKEAVSYIERHKHGPFLLFLSLLHVHIPLVTTSAFLGKSQHGLYGDNVEEMD 330
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 96.7 bits (239), Expect = 5e-20
Identities = 115/394 (29%), Positives = 156/394 (39%), Gaps = 112/394 (28%)
Query: 29 QPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLT 88
+P N LLLL DD G+ + G Y + TP+LD +A LLF N +++ CSPSRA+LLT
Sbjct: 21 RPRNALLLLADDGGF-ESGAYNNSAIATPHLDALARRSLLFRNAFTSVSSCSPSRASLLT 79
Query: 89 GRLPIRNGFY--TTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHR 146
G +NG Y + H N++ D + LP LL +AG + I+GK H+G
Sbjct: 80 GLPQHQNGMYGLHQDVHHFNSF----------DKVRSLPLLLSQAGVRTGIIGKKHVGPE 129
Query: 147 PQFHPLKHGFDEWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLT 206
+ P+D Y EE L+ G N+T
Sbjct: 130 TVY-------------------PFD----------------FAYTEENGSVLQVGR-NIT 153
Query: 207 QIYLQEALDFIKRQARHHPFFLYWAVDATH-----APVYAS---KPFLGTSQRGRYGD-- 256
+I L F++ Q PFFLY A H P Y + K G S GR D
Sbjct: 154 RIKLL-VRKFLQTQ-DDRPFFLYVAFHDPHRCGHSQPQYGTFCEKFGNGESGMGRIPDWT 211
Query: 257 ------------------------------AVREIDDSIGKILELLQDLHVADNTFVFFT 286
V +D +G +L+ L+D V ++T V FT
Sbjct: 212 PQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVLQELRDAGVLNDTLVIFT 271
Query: 287 SDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTA-GQVSHQLGSIMDL 345
SDNG PF G+ + G EP L P H GQVS S++DL
Sbjct: 272 SDNGI-------------PFPSGRTNLYWPGTAEPLLVSSPEHPKRWGQVSEAYVSLLDL 318
Query: 346 FTTSLALAGLTPPSDRA-------IDGLNLLPTL 372
T L + PS + G +LLP L
Sbjct: 319 TPTILDWFSIPYPSYAIFGSKTIHLTGRSLLPAL 352
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 82.0 bits (201), Expect = 1e-15
Identities = 109/429 (25%), Positives = 174/429 (40%), Gaps = 96/429 (22%)
Query: 10 WWQLLLVLSAAGMG----ASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE 65
W L+L +G A+ N+LL+++DD+ LG YG+ +PN+D++A+
Sbjct: 12 WLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASH 70
Query: 66 GLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNA----HARNAYTPQEIVGGIPDSE 121
LLF N ++ +C+PSR + LTGR P Y N+ HA N T
Sbjct: 71 SLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFST------------ 118
Query: 122 QLLPELLKKAGYVSKIVGK-WHLG----------HRPQFHPLKHGFDEWFGSPNCHFGPY 170
+P+ K+ GYV+ VGK +H G + F P +++ + C GP
Sbjct: 119 --IPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCR-GP- 174
Query: 171 DNKARPNI--PVYRDWEMVGRYYEEFPINLKTGEA-NLTQIYLQEALDFIKRQARHHPFF 227
D + N+ PV +++ P T +A L + A F H P
Sbjct: 175 DGELHANLLCPV----DVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHI 230
Query: 228 ----------LYWAVDATHA---------PVYASKPFLGTSQRG---------RYG---- 255
LY + T A P A P++ QR YG
Sbjct: 231 PFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPV 290
Query: 256 DAVREIDDS-----------IGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNG 304
D R+I S +G++L L DL +A++T + FTSD+G AL G +G
Sbjct: 291 DFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHGWAL-------GEHG 343
Query: 305 PFLCGKQTTFEGGMREPALAWWPGHVTA-GQVSHQLGSIMDLFTTSLALAGLTPPSDRAI 363
+ K + F+ P + + PG + + +L +D F ++ L S +
Sbjct: 344 EW--AKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDPFDSASQLMEPGRQSMDLV 401
Query: 364 DGLNLLPTL 372
+ ++L PTL
Sbjct: 402 ELVSLFPTL 410
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 76.6 bits (187), Expect = 5e-14
Identities = 105/418 (25%), Positives = 171/418 (40%), Gaps = 102/418 (24%)
Query: 13 LLLVLSAA--GMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFP 70
LLLVL G + + PN++LLL DD G+ P ++T L + G+ F
Sbjct: 27 LLLVLGGCLGVFGVAAGTRRPNVVLLLTDDQDEVLGGM--TPLKKTKAL--IGEMGMTFS 82
Query: 71 NFYSANPLCSPSRAALLTGRLP----IRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPE 126
+ Y + LC PSRA++LTG+ P + N N +++ QE P
Sbjct: 83 SAYVPSALCCPSRASILTGKYPHNHHVVNNTLEGNCSSKSWQKIQE--------PNTFPA 134
Query: 127 LLKK-AGYVSKIVGKWHLGH-RPQFHPLKH---GFDEWFG-SPNCHFGPY----DNKARP 176
+L+ GY + GK+ + P L+H G+ W+ N + Y + KAR
Sbjct: 135 ILRSMCGYQTFFAGKYLNEYGAPDAGGLEHVPLGWSYWYALEKNSKYYNYTLSINGKAR- 193
Query: 177 NIPVYRDWEMVGRYYEEFPINLKTGEANLTQIYLQEALDFIKRQARHHPFFLYWAVDATH 236
++ E + ++ LT + +LDF+ ++ PFF+ A A H
Sbjct: 194 ------------KHGENYSVDY------LTDVLANVSLDFLDYKSNFEPFFMMIATPAPH 235
Query: 237 AP-------------VYA---------------------------SKPFLGTSQRGRYGD 256
+P V+A S FL + R R+
Sbjct: 236 SPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPMTNSSIQFLDNAFRKRW-Q 294
Query: 257 AVREIDDSIGKILELLQDLHVADNTFVFFTSDNG--AALISAPEQGGSNGPFLCGKQTTF 314
+ +DD + K+++ L+ +NT++F+TSDNG S P K+ +
Sbjct: 295 TLLSVDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHTGQFSLP----------IDKRQLY 344
Query: 315 EGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTL 372
E ++ P L PG + Q S L + +DL T L +AG + +DG++LLP L
Sbjct: 345 EFDIKVPLLVRGPG-IKPNQTSKMLVANIDLGPTILDIAGY-DLNKTQMDGMSLLPIL 400
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 72.8 bits (177), Expect = 7e-13
Identities = 91/346 (26%), Positives = 140/346 (40%), Gaps = 86/346 (24%)
Query: 10 WWQLLLVLSAAGMG----ASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE 65
W L+L +G A+ N+LL+++DD+ LG YG+ +PN+D++A+
Sbjct: 12 WLGLVLSSVCVALGSETQANSTTDALNVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASH 70
Query: 66 GLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNA----HARNAYTPQEIVGGIPDSE 121
LLF N ++ +C+PSR + LTGR P Y N+ HA N T
Sbjct: 71 SLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFST------------ 118
Query: 122 QLLPELLKKAGYVSKIVGK-WHLG----------HRPQFHPLKHGFDEWFGSPNCHFGPY 170
+P+ K+ GYV+ VGK +H G + F P +++ + C GP
Sbjct: 119 --IPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYSWSFPPYHPSSEKYENTKTCR-GP- 174
Query: 171 DNKARPNI--PVYRDWEMVGRYYEEFPINLKTGEA-NLTQIYLQEALDFIKRQARHHPFF 227
D + N+ PV +++ P T +A L + A F H P
Sbjct: 175 DGELHANLLCPV----DVLDVPEGTLPDKQSTEQAIQLLEKMKTSASPFFLAVGYHKPHI 230
Query: 228 ----------LYWAVDATHA---------PVYASKPFLGTSQRG---------RYG---- 255
LY + T A P A P++ QR YG
Sbjct: 231 PFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYNPWMDIRQREDVQALNISVPYGPIPV 290
Query: 256 DAVREIDDS-----------IGKILELLQDLHVADNTFVFFTSDNG 290
D R+I S +G++L L DL +A++T + FTSD+G
Sbjct: 291 DFQRKIRQSYFASVSYLDTQVGRLLSALDDLQLANSTIIAFTSDHG 336
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 67.8 bits (164), Expect = 2e-11
Identities = 92/374 (24%), Positives = 148/374 (39%), Gaps = 59/374 (15%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE--GLLFPNFYSANPLCSPSRAALLT 88
PNI+L+L DD +LG S + N R E G F N + P+C PSR+++LT
Sbjct: 43 PNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLT 96
Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148
G+ + YT N N +P P + L GY + GK+ +
Sbjct: 97 GKYVHNHNVYTNN---ENCSSPSWQAMHEP---RTFAVYLNNTGYRTAFFGKYLNEYNGS 150
Query: 149 FHPLKHGFDEWFG-SPNCHFGPY-----DNKARPNIPVYRDW-------------EMVGR 189
+ P G+ EW G N F Y K + +D+ +M R
Sbjct: 151 YIP--PGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKR 208
Query: 190 YYEEFPINLKTGEA----------NLTQIYLQEALDFIKRQARHHP-FFLYWAVDATHAP 238
Y P+ + A +++Y A I + P +W + T
Sbjct: 209 MYPHRPVMMVISHAAPHGPEDSAPQFSKLY-PNASQHITPSYNYAPNMDKHWIMQYTGPM 267
Query: 239 VYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPE 298
+ F QR R + +DDS+ ++ +L + +NT++ +T+D+G +
Sbjct: 268 LPIHMEFTNILQRKRL-QTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI----- 321
Query: 299 QGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPP 358
G G + GK ++ +R P P V G + Q+ +DL T L +AGL P
Sbjct: 322 --GQFG-LVKGKSMPYDFDIRVPFFIRGPS-VEPGSIVPQIVLNIDLAPTILDIAGLDTP 377
Query: 359 SDRAIDGLNLLPTL 372
D +DG ++L L
Sbjct: 378 PD--VDGKSVLKLL 389
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 67.8 bits (164), Expect = 2e-11
Identities = 92/374 (24%), Positives = 148/374 (39%), Gaps = 59/374 (15%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE--GLLFPNFYSANPLCSPSRAALLT 88
PNI+L+L DD +LG S + N R E G F N + P+C PSR+++LT
Sbjct: 43 PNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLT 96
Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148
G+ + YT N N +P P + L GY + GK+ +
Sbjct: 97 GKYVHNHNVYTNN---ENCSSPSWQAMHEP---RTFAVYLNNTGYRTAFFGKYLNEYNGS 150
Query: 149 FHPLKHGFDEWFG-SPNCHFGPY-----DNKARPNIPVYRDW-------------EMVGR 189
+ P G+ EW G N F Y K + +D+ +M R
Sbjct: 151 YIP--PGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKR 208
Query: 190 YYEEFPINLKTGEA----------NLTQIYLQEALDFIKRQARHHP-FFLYWAVDATHAP 238
Y P+ + A +++Y A I + P +W + T
Sbjct: 209 MYPHRPVMMVISHAAPHGPEDSAPQFSKLY-PNASQHITPSYNYAPNMDKHWIMQYTGPM 267
Query: 239 VYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPE 298
+ F QR R + +DDS+ ++ +L + +NT++ +T+D+G +
Sbjct: 268 LPIHMEFTNILQRKRL-QTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI----- 321
Query: 299 QGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPP 358
G G + GK ++ +R P P V G + Q+ +DL T L +AGL P
Sbjct: 322 --GQFG-LVKGKSMPYDFDIRVPFFIRGPS-VEPGSIVPQIVLNIDLAPTILDIAGLDTP 377
Query: 359 SDRAIDGLNLLPTL 372
D +DG ++L L
Sbjct: 378 PD--VDGKSVLKLL 389
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 67.8 bits (164), Expect = 2e-11
Identities = 92/374 (24%), Positives = 148/374 (39%), Gaps = 59/374 (15%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE--GLLFPNFYSANPLCSPSRAALLT 88
PNI+L+L DD +LG S + N R E G F N + P+C PSR+++LT
Sbjct: 43 PNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLT 96
Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148
G+ + YT N N +P P + L GY + GK+ +
Sbjct: 97 GKYVHNHNVYTNN---ENCSSPSWQAMHEP---RTFAVYLNNTGYRTAFFGKYLNEYNGS 150
Query: 149 FHPLKHGFDEWFG-SPNCHFGPY-----DNKARPNIPVYRDW-------------EMVGR 189
+ P G+ EW G N F Y K + +D+ +M R
Sbjct: 151 YIP--PGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKR 208
Query: 190 YYEEFPINLKTGEA----------NLTQIYLQEALDFIKRQARHHP-FFLYWAVDATHAP 238
Y P+ + A +++Y A I + P +W + T
Sbjct: 209 MYPHRPVMMVISHAAPHGPEDSAPQFSKLY-PNASQHITPSYNYAPNMDKHWIMQYTGPM 267
Query: 239 VYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPE 298
+ F QR R + +DDS+ ++ +L + +NT++ +T+D+G +
Sbjct: 268 LPIHMEFTNILQRKRL-QTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI----- 321
Query: 299 QGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPP 358
G G + GK ++ +R P P V G + Q+ +DL T L +AGL P
Sbjct: 322 --GQFG-LVKGKSMPYDFDIRVPFFIRGPS-VEPGSIVPQIVLNIDLAPTILDIAGLDTP 377
Query: 359 SDRAIDGLNLLPTL 372
D +DG ++L L
Sbjct: 378 PD--VDGKSVLKLL 389
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 67.8 bits (164), Expect = 2e-11
Identities = 92/374 (24%), Positives = 148/374 (39%), Gaps = 59/374 (15%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE--GLLFPNFYSANPLCSPSRAALLT 88
PNI+L+L DD +LG S + N R E G F N + P+C PSR+++LT
Sbjct: 43 PNIILVLTDDQDV-ELG-----SLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLT 96
Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148
G+ + YT N N +P P + L GY + GK+ +
Sbjct: 97 GKYVHNHNVYTNN---ENCSSPSWQAMHEP---RTFAVYLNNTGYRTAFFGKYLNEYNGS 150
Query: 149 FHPLKHGFDEWFG-SPNCHFGPY-----DNKARPNIPVYRDW-------------EMVGR 189
+ P G+ EW G N F Y K + +D+ +M R
Sbjct: 151 YIP--PGWREWLGLIKNSRFYNYTVCRNGIKEKHGFDYAKDYFTDLITNESINYFKMSKR 208
Query: 190 YYEEFPINLKTGEA----------NLTQIYLQEALDFIKRQARHHP-FFLYWAVDATHAP 238
Y P+ + A +++Y A I + P +W + T
Sbjct: 209 MYPHRPVMMVISHAAPHGPEDSAPQFSKLY-PNASQHITPSYNYAPNMDKHWIMQYTGPM 267
Query: 239 VYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPE 298
+ F QR R + +DDS+ ++ +L + +NT++ +T+D+G +
Sbjct: 268 LPIHMEFTNILQRKRL-QTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHI----- 321
Query: 299 QGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPP 358
G G + GK ++ +R P P V G + Q+ +DL T L +AGL P
Sbjct: 322 --GQFG-LVKGKSMPYDFDIRVPFFIRGPS-VEPGSIVPQIVLNIDLAPTILDIAGLDTP 377
Query: 359 SDRAIDGLNLLPTL 372
D +DG ++L L
Sbjct: 378 PD--VDGKSVLKLL 389
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 64.7 bits (156), Expect = 2e-10
Identities = 97/396 (24%), Positives = 152/396 (38%), Gaps = 87/396 (21%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE--GLLFPNFYSANPLCSPSRAALLT 88
PNI+L+L DD +LG S + N R E G F N + P+C PSR+++LT
Sbjct: 44 PNIILVLTDDQDV-ELG-----SMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILT 97
Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148
G+ + YT N + + + + L GY + GK+ +
Sbjct: 98 GKYVHNHNTYTNNENCSSPSWQAQ------HESRTFAVYLNSTGYRTAFFGKYLNEYNGS 151
Query: 149 FHPLKHGFDEWFGS-PNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQ 207
+ P G+ EW G N F Y R + E G Y + LT
Sbjct: 152 YVP--PGWKEWVGLLKNSRFYNY-TLCRNGVK-----EKHGSDYSK---------DYLTD 194
Query: 208 IYLQEALDFI---KRQARHHPFFLYWAVDATHAPV----------------------YAS 242
+ +++ F K+ H P + + A H P YA
Sbjct: 195 LITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAP 254
Query: 243 KP------------------FLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVF 284
P F QR R + +DDS+ I +L + DNT++
Sbjct: 255 NPDKHWIMRYTGPMKPIHMEFTNMLQRKRL-QTLMSVDDSMETIYNMLVETGELDNTYIV 313
Query: 285 FTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMD 344
+T+D+G + G G + GK +E +R P P +V AG ++ + +D
Sbjct: 314 YTADHGYHI-------GQFG-LVKGKSMPYEFDIRVPFYVRGP-NVEAGCLNPHIVLNID 364
Query: 345 LFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDR 380
L T L +AGL P+D +DG ++L L R ++R
Sbjct: 365 LAPTILDIAGLDIPAD--MDGKSILKLLDTERPVNR 398
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 64.7 bits (156), Expect = 2e-10
Identities = 97/396 (24%), Positives = 152/396 (38%), Gaps = 87/396 (21%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE--GLLFPNFYSANPLCSPSRAALLT 88
PNI+L+L DD +LG S + N R E G F N + P+C PSR+++LT
Sbjct: 44 PNIILVLTDDQDV-ELG-----SMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILT 97
Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148
G+ + YT N + + + + L GY + GK+ +
Sbjct: 98 GKYVHNHNTYTNNENCSSPSWQAQ------HESRTFAVYLNSTGYRTAFFGKYLNEYNGS 151
Query: 149 FHPLKHGFDEWFGS-PNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQ 207
+ P G+ EW G N F Y R + E G Y + LT
Sbjct: 152 YVP--PGWKEWVGLLKNSRFYNY-TLCRNGVK-----EKHGSDYSK---------DYLTD 194
Query: 208 IYLQEALDFI---KRQARHHPFFLYWAVDATHAPV----------------------YAS 242
+ +++ F K+ H P + + A H P YA
Sbjct: 195 LITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAP 254
Query: 243 KP------------------FLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVF 284
P F QR R + +DDS+ I +L + DNT++
Sbjct: 255 NPDKHWIMRYTGPMKPIHMEFTNMLQRKRL-QTLMSVDDSMETIYNMLVETGELDNTYIV 313
Query: 285 FTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMD 344
+T+D+G + G G + GK +E +R P P +V AG ++ + +D
Sbjct: 314 YTADHGYHI-------GQFG-LVKGKSMPYEFDIRVPFYVRGP-NVEAGCLNPHIVLNID 364
Query: 345 LFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDR 380
L T L +AGL P+D +DG ++L L R ++R
Sbjct: 365 LAPTILDIAGLDIPAD--MDGKSILKLLDTERPVNR 398
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 64.7 bits (156), Expect = 2e-10
Identities = 97/396 (24%), Positives = 152/396 (38%), Gaps = 87/396 (21%)
Query: 31 PNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAE--GLLFPNFYSANPLCSPSRAALLT 88
PNI+L+L DD +LG S + N R E G F N + P+C PSR+++LT
Sbjct: 44 PNIILVLTDDQDV-ELG-----SMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILT 97
Query: 89 GRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQ 148
G+ + YT N + + + + L GY + GK+ +
Sbjct: 98 GKYVHNHNTYTNNENCSSPSWQAQ------HESRTFAVYLNSTGYRTAFFGKYLNEYNGS 151
Query: 149 FHPLKHGFDEWFGS-PNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKTGEANLTQ 207
+ P G+ EW G N F Y R + E G Y + LT
Sbjct: 152 YVP--PGWKEWVGLLKNSRFYNY-TLCRNGVK-----EKHGSDYSK---------DYLTD 194
Query: 208 IYLQEALDFI---KRQARHHPFFLYWAVDATHAPV----------------------YAS 242
+ +++ F K+ H P + + A H P YA
Sbjct: 195 LITNDSVSFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAP 254
Query: 243 KP------------------FLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVF 284
P F QR R + +DDS+ I +L + DNT++
Sbjct: 255 NPDKHWIMRYTGPMKPIHMEFTNMLQRKRL-QTLMSVDDSMETIYNMLVETGELDNTYIV 313
Query: 285 FTSDNGAALISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMD 344
+T+D+G + G G + GK +E +R P P +V AG ++ + +D
Sbjct: 314 YTADHGYHI-------GQFG-LVKGKSMPYEFDIRVPFYVRGP-NVEAGCLNPHIVLNID 364
Query: 345 LFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDR 380
L T L +AGL P+D +DG ++L L R ++R
Sbjct: 365 LAPTILDIAGLDIPAD--MDGKSILKLLDTERPVNR 398
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 58.9 bits (141), Expect = 1e-08
Identities = 97/415 (23%), Positives = 161/415 (38%), Gaps = 85/415 (20%)
Query: 3 AVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVY-GEPSRETPNLDR 61
+VVAA L ++ AG A + PN++L++ D G L + G + P ++
Sbjct: 7 SVVAALA---LAVLAPGAGEQRRRAAKAPNVVLVVSDSFD-GRLTFHPGSQVVKLPFINF 62
Query: 62 MAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSE 121
M G F N Y+ +P+C PSRAA+ +G +T + N + G+ +
Sbjct: 63 MKTRGTSFLNAYTNSPICCPSRAAMWSG-------LFTHLTESWNNFK------GLDPNY 109
Query: 122 QLLPELLKKAGYVSKIVGKWHLGHRPQFHPLKHGFDEWF----------GSPNCHFGPYD 171
+++++ GY ++ GK L + H + + + W G P +
Sbjct: 110 TTWMDVMERHGYRTQKFGK--LDYTSGHHSISNRVEAWTRDVAFLLRQEGRPMVNLIRNR 167
Query: 172 NKARPNIPVYRDWEMVGR-----------YYEEFPINLKTGEANLTQIYLQEALDFIKRQ 220
K R + RDW+ + Y E F I L NL Y +
Sbjct: 168 TKVRV---MERDWQNTDKAVNWLRKEAINYTEPFVIYLGL---NLPHPYPSPSSGENFGS 221
Query: 221 ARHHPFFLYWAVDATHAPV----------------YASKPFLGTSQ---------RGRYG 255
+ H LYW +H + Y+S T + R Y
Sbjct: 222 STFHTS-LYWLEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFTKKEIKNIRAFYY 280
Query: 256 DAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTFE 315
E D +G+I+ L L + T V ++SD+G E + F K + +E
Sbjct: 281 AMCAETDAMLGEIILALHQLDLLQKTIVIYSSDHG-------ELAMEHRQFY--KMSMYE 331
Query: 316 GGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLP 370
P L PG QVS+ + S++D++ T L +AG+ P + + G +LLP
Sbjct: 332 ASAHVPLLMMGPGIKAGLQVSNVV-SLVDIYPTMLDIAGIPLPQN--LSGYSLLP 383
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 55.8 bits (133), Expect = 9e-08
Identities = 34/99 (34%), Positives = 51/99 (51%), Gaps = 19/99 (19%)
Query: 55 ETPNLDRMAAEGLLFPNFYSANPLCSPSRAALLTGRLPIRNGFYTTNA----HARNAYTP 110
+ PN+D++A+ LLF N ++ +C+PSR + LTGR P Y N+ HA N T
Sbjct: 23 KAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAGNFST- 81
Query: 111 QEIVGGIPDSEQLLPELLKKAGYVSKIVGK-WHLGHRPQ 148
+P+ K+ GYV+ VGK +H G P+
Sbjct: 82 -------------IPQYFKENGYVTMSVGKVFHPGTAPR 107
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.448
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,828,935
Number of Sequences: 37866
Number of extensions: 1111952
Number of successful extensions: 2339
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2181
Number of HSP's gapped (non-prelim): 66
length of query: 522
length of database: 18,247,518
effective HSP length: 107
effective length of query: 415
effective length of database: 14,195,856
effective search space: 5891280240
effective search space used: 5891280240
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.