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Search of human proteins with 4503583
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503583 epoxide hydrolase 1 [Homo sapiens]
(455 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503583 epoxide hydrolase 1 [Homo sapiens] 950 0.0
gi|209862837 epoxide hydrolase 1 [Homo sapiens] 950 0.0
gi|29294639 mesoderm specific transcript isoform a [Homo sapiens] 40 0.004
gi|29294637 mesoderm specific transcript isoform b [Homo sapiens] 40 0.004
gi|29294635 mesoderm specific transcript isoform b [Homo sapiens] 40 0.004
gi|218777837 abhydrolase domain containing 7 [Homo sapiens] 38 0.022
gi|27597073 epoxide hydrolase 2, cytoplasmic [Homo sapiens] 36 0.063
gi|218777840 abhydrolase domain containing 9 [Homo sapiens] 36 0.082
gi|13376164 abhydrolase domain containing 9 [Homo sapiens] 36 0.082
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 35 0.18
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 33 0.53
gi|41281583 Histidine acid phosphatase domain containing 1 [Homo... 31 2.7
gi|21361571 CD48 molecule [Homo sapiens] 30 3.5
gi|119964728 D-2-hydroxyglutarate dehydrogenase precursor [Homo ... 30 3.5
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] 30 4.5
gi|18777795 serine hydrolase-like 2 [Homo sapiens] 29 7.7
>gi|4503583 epoxide hydrolase 1 [Homo sapiens]
Length = 455
Score = 950 bits (2455), Expect = 0.0
Identities = 455/455 (100%), Positives = 455/455 (100%)
Query: 1 MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI 60
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI
Sbjct: 1 MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI 60
Query: 61 HDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKI 120
HDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKI
Sbjct: 61 HDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKI 120
Query: 121 EGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEV 180
EGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEV
Sbjct: 121 EGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEV 180
Query: 181 ICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVP 240
ICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVP
Sbjct: 181 ICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVP 240
Query: 241 SHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM 300
SHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM
Sbjct: 241 SHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM 300
Query: 301 HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVML 360
HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVML
Sbjct: 301 HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVML 360
Query: 361 YWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL 420
YWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL
Sbjct: 361 YWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL 420
Query: 421 ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ 455
ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
Sbjct: 421 ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ 455
>gi|209862837 epoxide hydrolase 1 [Homo sapiens]
Length = 455
Score = 950 bits (2455), Expect = 0.0
Identities = 455/455 (100%), Positives = 455/455 (100%)
Query: 1 MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI 60
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI
Sbjct: 1 MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEI 60
Query: 61 HDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKI 120
HDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKI
Sbjct: 61 HDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKI 120
Query: 121 EGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEV 180
EGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEV
Sbjct: 121 EGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEV 180
Query: 181 ICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVP 240
ICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVP
Sbjct: 181 ICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVP 240
Query: 241 SHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM 300
SHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM
Sbjct: 241 SHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM 300
Query: 301 HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVML 360
HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVML
Sbjct: 301 HIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVML 360
Query: 361 YWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL 420
YWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL
Sbjct: 361 YWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKL 420
Query: 421 ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ 455
ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
Sbjct: 421 ISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ 455
>gi|29294639 mesoderm specific transcript isoform a [Homo sapiens]
Length = 335
Score = 40.0 bits (92), Expect = 0.004
Identities = 39/159 (24%), Positives = 62/159 (38%), Gaps = 38/159 (23%)
Query: 127 FIHVKPPQL-PAGHT--------------------------PKPLLMVHGWPGSFYEFYK 159
++H+ PPQL PA H+ P+ ++++HG+P S Y++YK
Sbjct: 28 YLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYK 87
Query: 160 IIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQE 219
I LT VI G+GFS+ ++ A I L+ LG Q
Sbjct: 88 IWEGLT---------LRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQN 138
Query: 220 FYIQ--GGDWGSLICTNMAQLVPSHVKGLHLNMALVLSN 256
I D+G ++ + + G +L LSN
Sbjct: 139 RRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSN 177
>gi|29294637 mesoderm specific transcript isoform b [Homo sapiens]
Length = 326
Score = 40.0 bits (92), Expect = 0.004
Identities = 39/159 (24%), Positives = 62/159 (38%), Gaps = 38/159 (23%)
Query: 127 FIHVKPPQL-PAGHT--------------------------PKPLLMVHGWPGSFYEFYK 159
++H+ PPQL PA H+ P+ ++++HG+P S Y++YK
Sbjct: 19 YLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYK 78
Query: 160 IIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQE 219
I LT VI G+GFS+ ++ A I L+ LG Q
Sbjct: 79 IWEGLT---------LRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQN 129
Query: 220 FYIQ--GGDWGSLICTNMAQLVPSHVKGLHLNMALVLSN 256
I D+G ++ + + G +L LSN
Sbjct: 130 RRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSN 168
>gi|29294635 mesoderm specific transcript isoform b [Homo sapiens]
Length = 326
Score = 40.0 bits (92), Expect = 0.004
Identities = 39/159 (24%), Positives = 62/159 (38%), Gaps = 38/159 (23%)
Query: 127 FIHVKPPQL-PAGHT--------------------------PKPLLMVHGWPGSFYEFYK 159
++H+ PPQL PA H+ P+ ++++HG+P S Y++YK
Sbjct: 19 YLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYK 78
Query: 160 IIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQE 219
I LT VI G+GFS+ ++ A I L+ LG Q
Sbjct: 79 IWEGLT---------LRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQN 129
Query: 220 FYIQ--GGDWGSLICTNMAQLVPSHVKGLHLNMALVLSN 256
I D+G ++ + + G +L LSN
Sbjct: 130 RRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSN 168
>gi|218777837 abhydrolase domain containing 7 [Homo sapiens]
Length = 362
Score = 37.7 bits (86), Expect = 0.022
Identities = 35/151 (23%), Positives = 66/151 (43%), Gaps = 27/151 (17%)
Query: 110 LNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPL-LMVHGWPGSFYEF-YKIIPLLTDP 167
L + + + K GL H++ AG KPL L++HG+P +Y + Y++ ++
Sbjct: 68 LGTHCYVRIKDSGLRFHYV-------AAGERGKPLMLLLHGFPEFWYSWRYQLREFKSE- 119
Query: 168 KNHGLSDEHVFEVICPSIPGYGFSEAS-SKKGFNSVATARIFYKLMLRLGFQEFYIQGGD 226
+ V+ + GYG ++A ++ + ++ LG+ + + G D
Sbjct: 120 ----------YRVVALDLRGYGETDAPIHRQNYKLDCLITDIKDILDSLGYSKCVLIGHD 169
Query: 227 WGSLICTNMAQLVPSHVKGLHLNMALVLSNF 257
WG +I +A P V M L++ NF
Sbjct: 170 WGGMIAWLIAICYPEMV------MKLIVINF 194
>gi|27597073 epoxide hydrolase 2, cytoplasmic [Homo sapiens]
Length = 555
Score = 36.2 bits (82), Expect = 0.063
Identities = 27/113 (23%), Positives = 47/113 (41%), Gaps = 11/113 (9%)
Query: 146 MVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSK-KGFNSVAT 204
+ HG+P S+Y + IP L + V+ + GYG S A + + +
Sbjct: 263 LCHGFPESWYSWRYQIPALAQAG---------YRVLAMDMKGYGESSAPPEIEEYCMEVL 313
Query: 205 ARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGL-HLNMALVLSN 256
+ + +LG + G DWG ++ MA P V+ + LN + +N
Sbjct: 314 CKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNTPFIPAN 366
>gi|218777840 abhydrolase domain containing 9 [Homo sapiens]
Length = 360
Score = 35.8 bits (81), Expect = 0.082
Identities = 31/138 (22%), Positives = 62/138 (44%), Gaps = 21/138 (15%)
Query: 110 LNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLM-VHGWPGSFYEF-YKIIPLLTDP 167
L + K GL +H++ AG PL++ +HG+P +++ + Y++
Sbjct: 72 LGEHGFLNLKSSGLRLHYVS-------AGRGNGPLMLFLHGFPENWFSWRYQLREF---- 120
Query: 168 KNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYK-LMLRLGFQEFYIQGGD 226
+ F V+ + GYG S+A ++ + K ++L LG+ + + D
Sbjct: 121 -------QSRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVILGLGYSKCILVAHD 173
Query: 227 WGSLICTNMAQLVPSHVK 244
WG+L+ + + PS V+
Sbjct: 174 WGALLAWHFSIYYPSLVE 191
>gi|13376164 abhydrolase domain containing 9 [Homo sapiens]
Length = 360
Score = 35.8 bits (81), Expect = 0.082
Identities = 31/138 (22%), Positives = 62/138 (44%), Gaps = 21/138 (15%)
Query: 110 LNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLM-VHGWPGSFYEF-YKIIPLLTDP 167
L + K GL +H++ AG PL++ +HG+P +++ + Y++
Sbjct: 72 LGEHGFLNLKSSGLRLHYVS-------AGRGNGPLMLFLHGFPENWFSWRYQLREF---- 120
Query: 168 KNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYK-LMLRLGFQEFYIQGGD 226
+ F V+ + GYG S+A ++ + K ++L LG+ + + D
Sbjct: 121 -------QSRFHVVAVDLRGYGPSDAPRDVDCYTIDLLLVDIKDVILGLGYSKCILVAHD 173
Query: 227 WGSLICTNMAQLVPSHVK 244
WG+L+ + + PS V+
Sbjct: 174 WGALLAWHFSIYYPSLVE 191
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 34.7 bits (78), Expect = 0.18
Identities = 22/73 (30%), Positives = 35/73 (47%), Gaps = 12/73 (16%)
Query: 93 VISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPG 152
V +WRN L R+ K I+ +IH ++P + AG LL+ G G
Sbjct: 3644 VSDHWRN----------LQRFLSHKLDIKRANIHLASLQPAEAVAG--VDVLLVFEGHSG 3691
Query: 153 SFYEFYKIIPLLT 165
+FYEF ++ ++T
Sbjct: 3692 TFYEFQELASIIT 3704
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 33.1 bits (74), Expect = 0.53
Identities = 44/167 (26%), Positives = 63/167 (37%), Gaps = 27/167 (16%)
Query: 195 SKKGFNSVATARIFYKLMLRLG-FQEFYIQGGDWGSLI----CTNMAQLVPSHVKGLHLN 249
+K F + A++ KL ++ + G W S++ TN +P V GL
Sbjct: 368 NKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSL 427
Query: 250 MALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYM--------- 300
L+LSN L L G L E D+E E SL E Y+
Sbjct: 428 EVLILSN--NLLKKLPHGLGNLRKLRELDLE------ENKLESLPNEIAYLKDLQKLVLT 479
Query: 301 -HIQCTKPDTVGSALNDSPVGLAAYIL----EKFSTWTNTEFRYLED 342
+ T P +G N + +GL +L E+ T N E YL D
Sbjct: 480 NNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLND 526
>gi|41281583 Histidine acid phosphatase domain containing 1 [Homo
sapiens]
Length = 1222
Score = 30.8 bits (68), Expect = 2.7
Identities = 13/35 (37%), Positives = 20/35 (57%)
Query: 35 GPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDK 69
G G R A+RE++ RPFK++ DE +D+
Sbjct: 909 GYGYRPASRENEGRRPFKIDNDDEPHTSKRDEVDR 943
>gi|21361571 CD48 molecule [Homo sapiens]
Length = 243
Score = 30.4 bits (67), Expect = 3.5
Identities = 13/39 (33%), Positives = 24/39 (61%)
Query: 86 NSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLD 124
NS Y+ +V+ NE +WK ++++L+ P KIE ++
Sbjct: 104 NSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIE 142
>gi|119964728 D-2-hydroxyglutarate dehydrogenase precursor [Homo
sapiens]
Length = 521
Score = 30.4 bits (67), Expect = 3.5
Identities = 27/88 (30%), Positives = 40/88 (45%), Gaps = 14/88 (15%)
Query: 225 GDWGSL-ICTNMAQLVPSHVKGLHL------NMALVLSNFSTLTLLLGQRFGRF------ 271
G G+L I T ++ L P + +++ A VL FST +LG+ F
Sbjct: 257 GSEGTLGIITTVSILCPPKPRAVNVAFLGCPGFAEVLQTFSTCKGMLGEILSAFEFMDAV 316
Query: 272 -LGLTERDVELLYPVKEKVFYSLMRESG 298
+ L R + L PV+E FY L+ SG
Sbjct: 317 CMQLVGRHLHLASPVQESPFYVLIETSG 344
>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
Length = 3062
Score = 30.0 bits (66), Expect = 4.5
Identities = 26/116 (22%), Positives = 48/116 (41%), Gaps = 4/116 (3%)
Query: 296 ESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLL 355
+S HI CT+PD +G +S + L A + +K ++ DG + ++D
Sbjct: 2454 DSSLDHIICTEPDLIGKPAEESHLSLIASVTDKDPQGNGSDLIKGRDG--KSDILIEDET 2511
Query: 356 TNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEK 411
+ +Y G ++ +EN + K+ R + S FPF + E+
Sbjct: 2512 SIQKMYLGEGEVLVEGLVEEENRHLKLLPGKNTRDSFKLIN--SQFPFPQITNNEE 2565
>gi|18777795 serine hydrolase-like 2 [Homo sapiens]
Length = 314
Score = 29.3 bits (64), Expect = 7.7
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 13/54 (24%)
Query: 143 PLLMVHGWPGSFYEFYKIIPLL--------TDPKNHGLSDEHVFEVICPSIPGY 188
P+L +HGW + F ++IPLL D HGLS + P +P Y
Sbjct: 34 PVLCLHGWLDNASSFDRLIPLLPQDFYYVAMDFGGHGLSSHY-----SPGVPYY 82
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.445
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,299,957
Number of Sequences: 37866
Number of extensions: 842591
Number of successful extensions: 1522
Number of sequences better than 10.0: 16
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1511
Number of HSP's gapped (non-prelim): 18
length of query: 455
length of database: 18,247,518
effective HSP length: 106
effective length of query: 349
effective length of database: 14,233,722
effective search space: 4967568978
effective search space used: 4967568978
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.