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Search of human proteins with 4503443
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo
sapiens]
(770 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens] 1584 0.0
gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo sapi... 1553 0.0
gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo sapi... 1550 0.0
gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo sapi... 1498 0.0
gi|153945836 endothelin converting enzyme 2 isoform E [Homo sapi... 1006 0.0
gi|153945771 endothelin converting enzyme 2 isoform D [Homo sapi... 991 0.0
gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens] 984 0.0
gi|153945761 endothelin converting enzyme 2 isoform A [Homo sapi... 984 0.0
gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens] 567 e-161
gi|116256333 membrane metallo-endopeptidase [Homo sapiens] 541 e-153
gi|116256331 membrane metallo-endopeptidase [Homo sapiens] 541 e-153
gi|116256327 membrane metallo-endopeptidase [Homo sapiens] 541 e-153
gi|116256329 membrane metallo-endopeptidase [Homo sapiens] 541 e-153
gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens] 532 e-151
gi|90403592 phosphate-regulating neutral endopeptidase [Homo sap... 472 e-133
gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens] 351 1e-96
gi|109826564 neurofibromin isoform 1 [Homo sapiens] 32 2.2
gi|4557793 neurofibromin isoform 2 [Homo sapiens] 32 2.2
gi|134152674 rabaptin, RAB GTPase binding effector protein 1 iso... 32 2.9
gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isof... 32 2.9
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 31 5.0
gi|154744870 zinc finger protein 574 [Homo sapiens] 30 6.5
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 30 8.5
gi|50345831 forkhead box J3 [Homo sapiens] 30 8.5
>gi|4503443 endothelin converting enzyme 1 isoform 1 [Homo sapiens]
Length = 770
Score = 1584 bits (4102), Expect = 0.0
Identities = 770/770 (100%), Positives = 770/770 (100%)
Query: 1 MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA 60
MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA
Sbjct: 1 MRGVWPPPVSALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWA 60
Query: 61 ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD 120
ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD
Sbjct: 61 ARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVD 120
Query: 121 PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV 180
PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV
Sbjct: 121 PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQV 180
Query: 181 YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY 240
YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY
Sbjct: 181 YYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVY 240
Query: 241 VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI 300
VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI
Sbjct: 241 VSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAI 300
Query: 301 RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE 360
RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE
Sbjct: 301 RPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVE 360
Query: 361 INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV 420
INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV
Sbjct: 361 INESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEV 420
Query: 421 MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS 480
MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS
Sbjct: 421 MYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLS 480
Query: 481 TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF 540
TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF
Sbjct: 481 TLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNF 540
Query: 541 SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG 600
SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG
Sbjct: 541 SWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGG 600
Query: 601 IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN 660
IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN
Sbjct: 601 IGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVN 660
Query: 661 GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP 720
GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP
Sbjct: 661 GRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTP 720
Query: 721 ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770
ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
Sbjct: 721 ESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770
>gi|164519140 endothelin converting enzyme 1 isoform 2 [Homo
sapiens]
Length = 767
Score = 1553 bits (4021), Expect = 0.0
Identities = 757/761 (99%), Positives = 757/761 (99%)
Query: 10 SALLSALGMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRL 69
S L AL MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRL
Sbjct: 7 SVLHLALQMSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRL 66
Query: 70 VVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYA 129
VVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYA
Sbjct: 67 VVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYA 126
Query: 130 CGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNET 189
CGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNET
Sbjct: 127 CGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNET 186
Query: 190 RIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSN 249
RIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSN
Sbjct: 187 RIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSN 246
Query: 250 SNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILD 309
SNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILD
Sbjct: 247 SNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILD 306
Query: 310 FETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVV 369
FETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVV
Sbjct: 307 FETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVV 366
Query: 370 YDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCL 429
YDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCL
Sbjct: 367 YDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCL 426
Query: 430 PRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET 489
PRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET
Sbjct: 427 PRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET 486
Query: 490 RKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQL 549
RKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQL
Sbjct: 487 RKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQL 546
Query: 550 RKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHEL 609
RKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHEL
Sbjct: 547 RKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHEL 606
Query: 610 THAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENI 669
THAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENI
Sbjct: 607 THAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENI 666
Query: 670 ADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLIT 729
ADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLIT
Sbjct: 667 ADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLIT 726
Query: 730 DPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770
DPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
Sbjct: 727 DPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 767
>gi|164519138 endothelin converting enzyme 1 isoform 4 [Homo
sapiens]
Length = 754
Score = 1550 bits (4012), Expect = 0.0
Identities = 753/753 (100%), Positives = 753/753 (100%)
Query: 18 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLA 77
MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLA
Sbjct: 2 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLA 61
Query: 78 AGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKAN 137
AGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKAN
Sbjct: 62 AGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKAN 121
Query: 138 PVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAK 197
PVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAK
Sbjct: 122 PVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAK 181
Query: 198 PLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQ 257
PLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQ
Sbjct: 182 PLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQ 241
Query: 258 SGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANI 317
SGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANI
Sbjct: 242 SGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANI 301
Query: 318 TIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQ 377
TIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQ
Sbjct: 302 TIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQ 361
Query: 378 ISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVS 437
ISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVS
Sbjct: 362 ISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVS 421
Query: 438 DTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKA 497
DTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKA
Sbjct: 422 DTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKA 481
Query: 498 DAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQ 557
DAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQ
Sbjct: 482 DAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQ 541
Query: 558 WSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQG 617
WSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQG
Sbjct: 542 WSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQG 601
Query: 618 REYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKA 677
REYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKA
Sbjct: 602 REYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKA 661
Query: 678 AYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRF 737
AYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRF
Sbjct: 662 AYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRF 721
Query: 738 RVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770
RVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW
Sbjct: 722 RVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 754
>gi|164519136 endothelin converting enzyme 1 isoform 3 [Homo
sapiens]
Length = 758
Score = 1498 bits (3878), Expect = 0.0
Identities = 727/729 (99%), Positives = 727/729 (99%)
Query: 42 PNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS 101
P LQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS
Sbjct: 30 PPSLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLS 89
Query: 102 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 161
EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK
Sbjct: 90 EACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIK 149
Query: 162 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ 221
HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ
Sbjct: 150 HLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQ 209
Query: 222 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY 281
DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY
Sbjct: 210 DTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGY 269
Query: 282 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT 341
LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT
Sbjct: 270 LNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQT 329
Query: 342 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK 401
LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK
Sbjct: 330 LAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRK 389
Query: 402 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 461
TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK
Sbjct: 390 TSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSK 449
Query: 462 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN 521
SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN
Sbjct: 450 SIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFN 509
Query: 522 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG 581
DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG
Sbjct: 510 DYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAG 569
Query: 582 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ 641
ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ
Sbjct: 570 ILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQ 629
Query: 642 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT 701
TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT
Sbjct: 630 TECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLT 689
Query: 702 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM 761
NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM
Sbjct: 690 NNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPM 749
Query: 762 NPPHKCEVW 770
NPPHKCEVW
Sbjct: 750 NPPHKCEVW 758
>gi|153945836 endothelin converting enzyme 2 isoform E [Homo
sapiens]
Length = 765
Score = 1006 bits (2602), Expect = 0.0
Identities = 477/755 (63%), Positives = 601/755 (79%), Gaps = 5/755 (0%)
Query: 18 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLA 77
M YKRATL +ED ++ EG A P+ ++V F + ++ +RTQ+E L +LLA
Sbjct: 14 MVEYKRATLRDEDAPETPVEGGASPDAMEVGFQ--KGTRQLLGSRTQLELVLAGASLLLA 71
Query: 78 AGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKA 136
A L+ CL ALG+QY + S S CL+EAC+ V IL S+D V PC DF+ ++CGGWI+
Sbjct: 72 ALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRR 131
Query: 137 NPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKAQVYYRACMNETRIEELR 195
NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K Q +Y +C+ RIEEL
Sbjct: 132 NPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELG 191
Query: 196 AKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQV 255
A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+VY+SADSK+SNSNVIQV
Sbjct: 192 AQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQV 251
Query: 256 DQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALA 315
DQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG R QMQQ+L+ E LA
Sbjct: 252 DQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTST-REQMQQVLELEIQLA 310
Query: 316 NITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYL 375
NIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P+E+++SEP+VVY +YL
Sbjct: 311 NITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYL 370
Query: 376 EQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFC 435
+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +E +YGTKK+C+PRW+ C
Sbjct: 371 QQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTC 430
Query: 436 VSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKE 495
+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+L L WMDE+TR++AKE
Sbjct: 431 ISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKE 490
Query: 496 KADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNR 555
KADAIY+MIG+P+FI++PKELD V++ Y D +F+N + +NFS +V ADQLRK P+R
Sbjct: 491 KADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSR 550
Query: 556 DQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDD 615
DQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNFGGIGVV+GHELTHAFDD
Sbjct: 551 DQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDD 610
Query: 616 QGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGL 675
QGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE +NGR TLGENIADNGGL
Sbjct: 611 QGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGL 670
Query: 676 KAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPS 735
KAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVRTPESSHEGL+TDPHSP+
Sbjct: 671 KAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPA 730
Query: 736 RFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770
RFRV+G+LSNS++F HF CP GSPMNP CEVW
Sbjct: 731 RFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 765
>gi|153945771 endothelin converting enzyme 2 isoform D [Homo
sapiens]
Length = 811
Score = 991 bits (2561), Expect = 0.0
Identities = 480/799 (60%), Positives = 602/799 (75%), Gaps = 47/799 (5%)
Query: 18 MSTYKRATLDEEDLVDSLSEGDAYPNGLQVNFHS---------------PRSGQRCW--- 59
M YKRATL +ED ++ EG A P+ ++V + PRS W
Sbjct: 14 MVEYKRATLRDEDAPETPVEGGASPDAMEVGKGASPFSPGPSPGMTPGTPRSSGLFWRVT 73
Query: 60 --------------------------AARTQVEKRLVVLVVLLAAGLVACLAALGIQY-Q 92
+RTQ+E L +LLAA L+ CL ALG+QY +
Sbjct: 74 CPHLRSISGLCSRTMVGFQKGTRQLLGSRTQLELVLAGASLLLAALLLGCLVALGVQYHR 133
Query: 93 TRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNL 152
S S CL+EAC+ V IL S+D V PC DF+ ++CGGWI+ NP+PDG SRW TF++L
Sbjct: 134 DPSHSTCLTEACIRVAGKILESLDRGVSPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSL 193
Query: 153 WEHNQAIIKHLLENSTA-SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI 211
W+ NQAI+KHLLEN+T S SEAE+K Q +Y +C+ RIEEL A+PL +LIE++GGWNI
Sbjct: 194 WDQNQAILKHLLENTTFNSSSEAEQKTQRFYLSCLQVERIEELGAQPLRDLIEKIGGWNI 253
Query: 212 TGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNK 271
TGPW +DNF + L+ V YR +PFF+VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+
Sbjct: 254 TGPWDQDNFMEVLKAVAGTYRATPFFTVYISADSKSSNSNVIQVDQSGLFLPSRDYYLNR 313
Query: 272 TENEKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIY 331
T NEKVLT YL+YM +LG LLGG R QMQQ+L+ E LANIT+PQ++RRDEE IY
Sbjct: 314 TANEKVLTAYLDYMEELGMLLGGRPTST-REQMQQVLELEIQLANITVPQDQRRDEEKIY 372
Query: 332 HKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLINTTDRCLLN 391
HK++ +ELQ LAP+++WL FL+ + P+E+++SEP+VVY +YL+Q+S LIN T+ +LN
Sbjct: 373 HKMSISELQALAPSMDWLEFLSFLLSPLELSDSEPVVVYGMDYLQQVSELINRTEPSILN 432
Query: 392 NYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMF 451
NY+IWNLV+KT+S LD+RF+ A EK +E +YGTKK+C+PRW+ C+S+T++ LGFALG +F
Sbjct: 433 NYLIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCVPRWQTCISNTDDALGFALGSLF 492
Query: 452 VKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIM 511
VKATF SK IA +I EI+ AFEE+L L WMDE+TR++AKEKADAIY+MIG+P+FI+
Sbjct: 493 VKATFDRQSKEIAEGMISEIRTAFEEALGQLVWMDEKTRQAAKEKADAIYDMIGFPDFIL 552
Query: 512 DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSP 571
+PKELD V++ Y D +F+N + +NFS +V ADQLRK P+RDQWSMTP VNAYY P
Sbjct: 553 EPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLP 612
Query: 572 TKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWK 631
TKNEIVFPAGILQAPFY R+ PKALNFGGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+
Sbjct: 613 TKNEIVFPAGILQAPFYARNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQ 672
Query: 632 NSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGA 691
N S+ AF+ T CM EQY+ Y VNGE +NGR TLGENIADNGGLKAAY AY+ W++K+G
Sbjct: 673 NESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKAAYNAYKAWLRKHGE 732
Query: 692 EHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSE 751
E LP +GLTN+QLFF+GFAQVWCSVRTPESSHEGL+TDPHSP+RFRV+G+LSNS++F
Sbjct: 733 EQQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSPARFRVLGTLSNSRDFLR 792
Query: 752 HFRCPPGSPMNPPHKCEVW 770
HF CP GSPMNP CEVW
Sbjct: 793 HFGCPVGSPMNPGQLCEVW 811
>gi|82617560 endothelin converting enzyme 2 isoform B [Homo sapiens]
Length = 736
Score = 984 bits (2544), Expect = 0.0
Identities = 462/712 (64%), Positives = 577/712 (81%), Gaps = 3/712 (0%)
Query: 61 ARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTV 119
+RTQ+E L +LLAA L+ CL ALG+QY + S S CL+EAC+ V IL S+D V
Sbjct: 26 SRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGV 85
Query: 120 DPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKA 178
PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K
Sbjct: 86 SPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 145
Query: 179 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFS 238
Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+
Sbjct: 146 QRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFT 205
Query: 239 VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEE 298
VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG
Sbjct: 206 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTS 265
Query: 299 AIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP 358
R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P
Sbjct: 266 T-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP 324
Query: 359 VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 418
+E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +
Sbjct: 325 LELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLL 384
Query: 419 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 478
E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+
Sbjct: 385 ETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 444
Query: 479 LSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 538
L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V++ Y D +F+N + +
Sbjct: 445 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 504
Query: 539 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNF 598
NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNF
Sbjct: 505 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 564
Query: 599 GGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP 658
GGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE
Sbjct: 565 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGER 624
Query: 659 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVR 718
+NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVR
Sbjct: 625 LNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVR 684
Query: 719 TPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770
TPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GSPMNP CEVW
Sbjct: 685 TPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 736
>gi|153945761 endothelin converting enzyme 2 isoform A [Homo
sapiens]
Length = 883
Score = 984 bits (2544), Expect = 0.0
Identities = 462/712 (64%), Positives = 577/712 (81%), Gaps = 3/712 (0%)
Query: 61 ARTQVEKRLVVLVVLLAAGLVACLAALGIQY-QTRSPSVCLSEACVSVTSSILSSMDPTV 119
+RTQ+E L +LLAA L+ CL ALG+QY + S S CL+EAC+ V IL S+D V
Sbjct: 173 SRTQLELVLAGASLLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVAGKILESLDRGV 232
Query: 120 DPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTA-SVSEAERKA 178
PC DF+ ++CGGWI+ NP+PDG SRW TF++LW+ NQAI+KHLLEN+T S SEAE+K
Sbjct: 233 SPCEDFYQFSCGGWIRRNPLPDGRSRWNTFNSLWDQNQAILKHLLENTTFNSSSEAEQKT 292
Query: 179 QVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTAHYRTSPFFS 238
Q +Y +C+ RIEEL A+PL +LIE++GGWNITGPW +DNF + L+ V YR +PFF+
Sbjct: 293 QRFYLSCLQVERIEELGAQPLRDLIEKIGGWNITGPWDQDNFMEVLKAVAGTYRATPFFT 352
Query: 239 VYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGGDEE 298
VY+SADSK+SNSNVIQVDQSGL LPSRDYYLN+T NEKVLT YL+YM +LG LLGG
Sbjct: 353 VYISADSKSSNSNVIQVDQSGLFLPSRDYYLNRTANEKVLTAYLDYMEELGMLLGGRPTS 412
Query: 299 AIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYP 358
R QMQQ+L+ E LANIT+PQ++RRDEE IYHK++ +ELQ LAP+++WL FL+ + P
Sbjct: 413 T-REQMQQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQALAPSMDWLEFLSFLLSP 471
Query: 359 VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFM 418
+E+++SEP+VVY +YL+Q+S LIN T+ +LNNY+IWNLV+KT+S LD+RF+ A EK +
Sbjct: 472 LELSDSEPVVVYGMDYLQQVSELINRTEPSILNNYLIWNLVQKTTSSLDRRFESAQEKLL 531
Query: 419 EVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEES 478
E +YGTKK+C+PRW+ C+S+T++ LGFALG +FVKATF SK IA +I EI+ AFEE+
Sbjct: 532 ETLYGTKKSCVPRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEA 591
Query: 479 LSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFF 538
L L WMDE+TR++AKEKADAIY+MIG+P+FI++PKELD V++ Y D +F+N + +
Sbjct: 592 LGQLVWMDEKTRQAAKEKADAIYDMIGFPDFILEPKELDDVYDGYEISEDSFFQNMLNLY 651
Query: 539 NFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNF 598
NFS +V ADQLRK P+RDQWSMTP VNAYY PTKNEIVFPAGILQAPFY R+ PKALNF
Sbjct: 652 NFSAKVMADQLRKPPSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARNHPKALNF 711
Query: 599 GGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEP 658
GGIGVV+GHELTHAFDDQGREYDK+GNLRPWW+N S+ AF+ T CM EQY+ Y VNGE
Sbjct: 712 GGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGER 771
Query: 659 VNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVR 718
+NGR TLGENIADNGGLKAAY AY+ W++K+G E LP +GLTN+QLFF+GFAQVWCSVR
Sbjct: 772 LNGRQTLGENIADNGGLKAAYNAYKAWLRKHGEEQQLPAVGLTNHQLFFVGFAQVWCSVR 831
Query: 719 TPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770
TPESSHEGL+TDPHSP+RFRV+G+LSNS++F HF CP GSPMNP CEVW
Sbjct: 832 TPESSHEGLVTDPHSPARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLCEVW 883
>gi|239049391 membrane metallo-endopeptidase-like 1 [Homo sapiens]
Length = 779
Score = 567 bits (1461), Expect = e-161
Identities = 281/707 (39%), Positives = 433/707 (61%), Gaps = 29/707 (4%)
Query: 88 GIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWG 147
GI VC + CV + IL +MDPT +PC DF+ +ACGGW++ + +P+ +SR+
Sbjct: 78 GIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYS 137
Query: 148 TFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLG 207
F L + + I+K +LENSTA A KA+ YR+CMN++ IE+ ++PL++++E +G
Sbjct: 138 IFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVG 197
Query: 208 GWNITGPWAKDNFQDT----------LQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQ 257
GW P A D + +T L ++ + + +++ D +NS+ ++I +DQ
Sbjct: 198 GW----PVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQ 253
Query: 258 SGLGLPSRDYYLNKTENEKVLTGYLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFET 312
LG+PSR+YY N N KV YL +MV + LL D ++ M Q+L+ ET
Sbjct: 254 PTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELET 313
Query: 313 ALANITIPQEKRRDEELIYHKVTAAELQTL--APAINWLPFLNTIFYPVEIN--ESEPIV 368
LA T+PQE+R D +YH++ ELQ+ NW F+ T+ V+I E +V
Sbjct: 314 QLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVV 373
Query: 369 VYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTC 428
VY YL+ + +I+T + NY++W LV L QRF+D + + ++GT
Sbjct: 374 VYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEE 433
Query: 429 LPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEE 488
+ RW+ CV +N+ A+G ++V+ F DSKS+ E+I +++ F E+L L WMDEE
Sbjct: 434 V-RWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEE 492
Query: 489 TRKSAKEKADAIYNMIGYPNFIMDP--KELDKVFNDYTAVPDLYFENAMRFFNFSWRVTA 546
++K A+EKA +I IG+P++I++ + LD+ +++ DLYFEN+++ + +
Sbjct: 493 SKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSL 552
Query: 547 DQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVG 606
+LR+ + + W + +VNA+YSP +N+IVFPAGILQ PF+++ P+ALNFGGIG+V+G
Sbjct: 553 RKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIG 612
Query: 607 HELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRH 663
HE+TH FDD GR +DK+GN+ WW N S + F+ Q+ECM+ QY NYS + + VNG +
Sbjct: 613 HEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFN 672
Query: 664 TLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESS 723
TLGENIADNGG++ AY+AY W+ + G + LP L LT+ QLFF+ +AQVWC PE +
Sbjct: 673 TLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFA 732
Query: 724 HEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770
+ + TD HSP ++RV+GSL N F++ F C G+PM+P +C VW
Sbjct: 733 IQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW 779
>gi|116256333 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 541 bits (1393), Expect = e-153
Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)
Query: 47 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 106
+N P+ QR W T +E L VLV+LL V +A Y T +C S C+
Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
Query: 107 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 166
+ ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+
Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
Query: 167 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 220
A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A
Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
Query: 221 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 280
+ + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T
Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
Query: 281 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 335
Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T
Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
Query: 336 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 387
A++Q +WL F N I V I+ E +VVY EYL ++ ++
Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
Query: 388 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 447
L N M W + S L + ++++ F + +YGT W+ C + N+ A+
Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
Query: 448 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 507
G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP
Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
Query: 508 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 566
+ I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN
Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
Query: 567 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 626
A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
Query: 627 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 683
WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ
Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
Query: 684 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 743
N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L
Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
Query: 744 SNSKEFSEHFRCPPGSPMNPPHKCEVW 770
NS EFSE F C S MNP KC VW
Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|116256331 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 541 bits (1393), Expect = e-153
Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)
Query: 47 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 106
+N P+ QR W T +E L VLV+LL V +A Y T +C S C+
Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
Query: 107 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 166
+ ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+
Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
Query: 167 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 220
A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A
Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
Query: 221 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 280
+ + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T
Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
Query: 281 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 335
Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T
Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
Query: 336 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 387
A++Q +WL F N I V I+ E +VVY EYL ++ ++
Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
Query: 388 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 447
L N M W + S L + ++++ F + +YGT W+ C + N+ A+
Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
Query: 448 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 507
G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP
Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
Query: 508 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 566
+ I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN
Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
Query: 567 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 626
A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
Query: 627 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 683
WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ
Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
Query: 684 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 743
N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L
Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
Query: 744 SNSKEFSEHFRCPPGSPMNPPHKCEVW 770
NS EFSE F C S MNP KC VW
Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|116256327 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 541 bits (1393), Expect = e-153
Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)
Query: 47 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 106
+N P+ QR W T +E L VLV+LL V +A Y T +C S C+
Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
Query: 107 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 166
+ ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+
Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
Query: 167 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 220
A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A
Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
Query: 221 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 280
+ + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T
Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
Query: 281 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 335
Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T
Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
Query: 336 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 387
A++Q +WL F N I V I+ E +VVY EYL ++ ++
Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
Query: 388 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 447
L N M W + S L + ++++ F + +YGT W+ C + N+ A+
Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
Query: 448 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 507
G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP
Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
Query: 508 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 566
+ I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN
Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
Query: 567 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 626
A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
Query: 627 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 683
WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ
Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
Query: 684 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 743
N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L
Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
Query: 744 SNSKEFSEHFRCPPGSPMNPPHKCEVW 770
NS EFSE F C S MNP KC VW
Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|116256329 membrane metallo-endopeptidase [Homo sapiens]
Length = 750
Score = 541 bits (1393), Expect = e-153
Identities = 290/747 (38%), Positives = 429/747 (57%), Gaps = 32/747 (4%)
Query: 47 VNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGIQYQTRSPSVCLSEACVS 106
+N P+ QR W T +E L VLV+LL V +A Y T +C S C+
Sbjct: 13 INTPKPKKKQR-W---TPLEISLSVLVLLLTIIAVTMIAL----YATYDDGICKSSDCIK 64
Query: 107 VTSSILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLEN 166
+ ++ +MD T +PC DFF YACGGW+K N +P+ SR+G F L + + ++K +L+
Sbjct: 65 SAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQE 124
Query: 167 STASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNI-TGPW-----AKDNF 220
A +KA+ YR+C+NE+ I+ +PL++L+ + GW + T W A
Sbjct: 125 PKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTA 184
Query: 221 QDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEKVLTG 280
+ + + + Y +++V D KNS ++VI +DQ LGLPSRDYY ++ T
Sbjct: 185 EKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTA 244
Query: 281 YLNYMVQLGKLLGGG-----DEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVT 335
Y+++M+ + +L+ DE + +M ++++ E +AN T E R D L+Y+K+T
Sbjct: 245 YVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMT 304
Query: 336 AAELQTL------APAINWLPFLNTIFYPVEIN--ESEPIVVYDKEYLEQISTLINTTDR 387
A++Q +WL F N I V I+ E +VVY EYL ++ ++
Sbjct: 305 LAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSA 364
Query: 388 CLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFAL 447
L N M W + S L + ++++ F + +YGT W+ C + N+ A+
Sbjct: 365 RDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETAT-WRRCANYVNGNMENAV 423
Query: 448 GPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 507
G ++V+A FA +SK + ++I +I++ F ++L L WMD ET+K A+EKA AI IGYP
Sbjct: 424 GRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYP 483
Query: 508 NFIM-DPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVN 566
+ I+ + +L+ + + D YFEN ++ FS +LR+ ++D+W +VN
Sbjct: 484 DDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVN 543
Query: 567 AYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNL 626
A+YS +N+IVFPAGILQ PF++ +LN+GGIG+V+GHE+TH FDD GR ++KDG+L
Sbjct: 544 AFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDL 603
Query: 627 RPWWKNSSVEAFKRQTECMVEQYSNYS---VNGEPVNGRHTLGENIADNGGLKAAYRAYQ 683
WW S FK Q++CMV QY N+S G+ +NG +TLGENIADNGGL AYRAYQ
Sbjct: 604 VDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQ 663
Query: 684 NWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSL 743
N++KKNG E LP L L + QLFFL FAQVWC PE + + TD HSP FR+IG+L
Sbjct: 664 NYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTL 723
Query: 744 SNSKEFSEHFRCPPGSPMNPPHKCEVW 770
NS EFSE F C S MNP KC VW
Sbjct: 724 QNSAEFSEAFHCRKNSYMNPEKKCRVW 750
>gi|157426891 endothelin converting enzyme-like 1 [Homo sapiens]
Length = 775
Score = 532 bits (1371), Expect = e-151
Identities = 281/754 (37%), Positives = 436/754 (57%), Gaps = 25/754 (3%)
Query: 36 SEGDAYPNGLQVNFHSPRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAA-LGIQYQT- 93
+ G + P G + +G R R + ++ ++ AAGL A LAA L ++Y
Sbjct: 28 ARGASLPPGFPLGAARSATGARSGLPRWNRREVCLLSGLVFAAGLCAILAAMLALKYLGP 87
Query: 94 ------RSPSVCLSEACVSVTSSILSS-MDPTVDPCHDFFSYACGGWIKANPVPDGHSRW 146
P C + + L++ +D ++DPC DF+S+ACGGW++ + +PD +
Sbjct: 88 VAAGGGACPEGCPERKAFARAARFLAANLDASIDPCQDFYSFACGGWLRRHAIPDDKLTY 147
Query: 147 GTFSNLWEHNQAIIKHLLENSTASVS-EAERKAQVYYRACMNETRIEELRAKPLMELIER 205
GT + + E N+ ++ LL A+RK + ++R+C++ IE L +P++E+IE
Sbjct: 148 GTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREIERLGPRPMLEVIED 207
Query: 206 LGGWNITGPW------AKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSG 259
GGW++ G A+ + L Y + FS+ VS D +NS+ VI++DQ G
Sbjct: 208 CGGWDLGGAEERPGVAARWDLNRLLYKAQGVYSAAALFSLTVSLDDRNSSRYVIRIDQDG 267
Query: 260 LGLPSRDYYLNKTEN-EKVLTGYLNYMVQLGKLLGGGDEEAIRPQMQQILDFETALANIT 318
L LP R YL + E+ EK+L Y +M ++ LLG +A+ + Q+IL E LANIT
Sbjct: 268 LTLPERTLYLAQDEDSEKILAAYRVFMERVLSLLGA---DAVEQKAQEILQVEQQLANIT 324
Query: 319 IPQ--EKRRDEELIYHKVTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEYLE 376
+ + + RRD +Y+KVT +LQ + P + W L+ IF + +E E +V+ +Y++
Sbjct: 325 VSEHDDLRRDVSSMYNKVTLGQLQKITPHLRWKWLLDQIFQE-DFSEEEEVVLLATDYMQ 383
Query: 377 QISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCLPRWKFCV 436
Q+S LI +T +L+NY++W +V S L F++A + + M G+ K + C+
Sbjct: 384 QVSQLIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHELAQEMEGSDKP-QELARVCL 442
Query: 437 SDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEK 496
+ G ALG +FV F+ SK+ +++ +IK + L L WMD ETR +A+ K
Sbjct: 443 GQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEELDWMDAETRAAARAK 502
Query: 497 ADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRD 556
+ M+GYP+F++ P +DK + ++ YF+N + FS +++ ++R+ ++
Sbjct: 503 LQYMMVMVGYPDFLLKPDAVDKEY-EFEVHEKTYFKNILNSIRFSIQLSVKKIRQEVDKS 561
Query: 557 QWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQ 616
W + P +NAYY P KN++VFPAGILQ Y P++LN+GGIG ++GHELTH +DD
Sbjct: 562 TWLLPPQALNAYYLPNKNQMVFPAGILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDDW 621
Query: 617 GREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHTLGENIADNGGLK 676
G +YD+ GNL WW +S F R+ EC+V Y N++V + VNG+HTLGENIAD GGLK
Sbjct: 622 GGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHTLGENIADMGGLK 681
Query: 677 AAYRAYQNWVKKNGAEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSR 736
AY AYQ WV+++G EH LP L T++QLFF+ FAQ WC R +S + ++TD H+P
Sbjct: 682 LAYHAYQKWVREHGPEHPLPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVLTDKHAPEH 741
Query: 737 FRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 770
+RV+GS+S +EF F CP SPMNP HKC VW
Sbjct: 742 YRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW 775
>gi|90403592 phosphate-regulating neutral endopeptidase [Homo
sapiens]
Length = 749
Score = 472 bits (1214), Expect = e-133
Identities = 271/722 (37%), Positives = 401/722 (55%), Gaps = 30/722 (4%)
Query: 76 LAAGLVACLAALGIQYQTRSPSVCLSEACVSVTSSILSSMDPTVDPCHDFFSYACGGWIK 135
L G + L + G+ CL C+ ++ILS ++ +VDPC +FF +AC GWI
Sbjct: 31 LVLGTILFLVSQGLLSLQAKQEYCLKPECIEAAAAILSKVNLSVDPCDNFFRFACDGWIS 90
Query: 136 ANPVPDGHSRWGTFSNLWEHNQAIIKHLLENSTASV--SEAERKAQVYYRACMNETRIEE 193
NP+P+ +G + L + +K LLE S + +EA +KA++ Y +CMNE IE+
Sbjct: 91 NNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKILYSSCMNEKAIEK 150
Query: 194 LRAKPLMELIERLG-GWNIT-------GPWAKDNFQ--DTLQVVTAHYRTSPFFSVYVSA 243
AKPL+ ++ W + G W++ F TL Y S F +YVS
Sbjct: 151 ADAKPLLHILRHSPFRWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNSVFIRLYVSP 210
Query: 244 DSKNSNSNVIQVDQSGLGLPSRDYYL-NKTENEKVLTGYLNYMVQLGKLLGGGDEEAIRP 302
D K SN +++++DQ+ L L R+ YL N TE + +MV LLG A
Sbjct: 211 DDKASNEHILKLDQATLSLAVREDYLDNSTEAKSYRDALYKFMVDTAVLLGANSSRA-EH 269
Query: 303 QMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPAINWLPFL----NTIFYP 358
M+ +L E +A I IP E R E + Y+K+ +EL + P +WL ++ +T YP
Sbjct: 270 DMKSVLRLEIKIAEIMIPHENRTSEAM-YNKMNISELSAMIPQFDWLGYIKKVIDTRLYP 328
Query: 359 --VEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEK 416
+I+ SE +VV +Y + + ++ + + + NY++W +V L +RFQ +
Sbjct: 329 HLKDISPSENVVVRVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLE 388
Query: 417 FMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFE 476
F V+ GT T LP+W CV+ E+ L + +G MFV F ED K + E++ ++ AF
Sbjct: 389 FSRVIQGTT-TLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFI 447
Query: 477 ESLSTL-KWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAM 535
+ L +WMD T++ AKEKA A+ +GYP FIM+ +++ YF N +
Sbjct: 448 DMLEKENEWMDAGTKRKAKEKARAVLAKVGYPEFIMNDTHVNEDLKAIKFSEADYFGNVL 507
Query: 536 RFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSS-PK 594
+ + + LRKA + +W P VNA+YS + N+I FPAG LQ PF+ + P+
Sbjct: 508 QTRKYLAQSDFFWLRKAVPKTEWFTNPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPR 567
Query: 595 ALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNY-- 652
+L++G IGV+VGHE TH FD+ GR+YDK+GNL PWW S E FK +T+CM+ QYSNY
Sbjct: 568 SLSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYW 627
Query: 653 SVNGEPVNGRHTLGENIADNGGLKAAYRAYQNWV--KKNGAEHS-LPTLGLTNNQLFFLG 709
G V G+ TLGENIADNGGL+ A+RAY+ W+ ++ G E LP + TNNQLFFL
Sbjct: 628 KKAGLNVKGKRTLGENIADNGGLREAFRAYRKWINDRRQGLEEPLLPGITFTNNQLFFLS 687
Query: 710 FAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMN-PPHKCE 768
+A V C+ PE++ E + HSP +FRV G++SN +EF + F CPP S MN C
Sbjct: 688 YAHVRCNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCR 747
Query: 769 VW 770
+W
Sbjct: 748 LW 749
>gi|4557691 Kell blood group, metallo-endopeptidase [Homo sapiens]
Length = 732
Score = 351 bits (901), Expect = 1e-96
Identities = 230/733 (31%), Positives = 359/733 (48%), Gaps = 49/733 (6%)
Query: 52 PRSGQRCWAARTQVEKRLVVLVVLLAAGLVACLAALGI-QYQTRSPSVCLSEACVSVTSS 110
P G R WA +V L +L GL+ C + L +Q P C + C+ +
Sbjct: 35 PVEGSRPWAVARRV------LTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDH 88
Query: 111 ILSSMDPTVDPCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAIIKHLLE-NSTA 169
L+S + +V PC DFFS+ACG + N +F L N+ ++ +LE ++
Sbjct: 89 YLASGNTSVAPCTDFFSFACGRAKETN---------NSFQELATKNKNRLRRILEVQNSW 139
Query: 170 SVSEAERKAQVYYRACMNETRIEELRAKPLMELIERLGGWNITGPWAKDNFQDTLQVVTA 229
E KA +Y +CM+ IE PL ++IE LGGW I+G W NF TL+++ +
Sbjct: 140 HPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMS 199
Query: 230 HYRTSPFFSVYVSADSKNSNSNVIQVDQSGLGLPSRDYYLNKTENEK----VLTGYLNYM 285
Y PFF Y+ + ++ VIQ+DQ P D L + + +K + YL Y+
Sbjct: 200 QYGHFPFFRAYLGPHPASPHTPVIQIDQ-----PEFDVPLKQDQEQKIYAQIFREYLTYL 254
Query: 286 VQLGKLLGGGDEEAIRPQMQQILDFETALANITIPQEKRRDEELIYHKVTAAELQTLAPA 345
QLG LL GGD ++ + + L P E+RR + ++ VT +L+ +APA
Sbjct: 255 NQLGTLL-GGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPA 313
Query: 346 INWLPFLNTIFYPVEINESEPIVVYDKEYLEQISTLIN---TTDRCLLNNYMIWNLVRKT 402
I+WL L F P+ ++ S+ +VV+D EYL+ +S L+ R L ++MI LV
Sbjct: 314 IDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTL 373
Query: 403 SSFLDQRFQDA----DEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAE 458
S LD +FQ+A +K E+ PRW CV +T L +FV+ F
Sbjct: 374 SPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGP 433
Query: 459 DSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYPNFIMDPKELDK 518
++S A ++ I+ A L L WM+EET+ A++K + +G + + P+ +
Sbjct: 434 STRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQ 493
Query: 519 VFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPNRDQWSMTPPMVNAYYSPTKNEIVF 578
+ND + R+ L+ P + +W ++P VNAYYS + + +VF
Sbjct: 494 EYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHP-QHRWKVSPWDVNAYYSVSDHVVVF 552
Query: 579 PAGILQAPFYTRSSPKALNFGGIGVVVGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAF 638
PAG+LQ PF+ P+A+NFG G ++ HEL H F + G ++ EA
Sbjct: 553 PAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIF----YQLLLPGGCLACDNHALQEAH 608
Query: 639 KRQTECMVEQYSNYSV-NGEPVNGRHTLGENIADNGGLKAAYRAYQNWVKKNGAEHSLPT 697
C+ Y+ + + + N T EN AD GGL A +AY + ++ E LP+
Sbjct: 609 L----CLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPS 664
Query: 698 LGLTNNQLFFLGFAQVWCSVRTPESSHEGLITDPHSPSRFRVIGSLSNSKEFSEHFRCPP 757
L L+ Q+FF +AQV C +P+ SH D HSP RV G LS++ F+ +FRC
Sbjct: 665 LDLSPQQIFFRSYAQVMCRKPSPQDSH-----DTHSPPHLRVHGPLSSTPAFARYFRCAR 719
Query: 758 GSPMNPPHKCEVW 770
G+ +NP +C++W
Sbjct: 720 GALLNPSSRCQLW 732
>gi|109826564 neurofibromin isoform 1 [Homo sapiens]
Length = 2839
Score = 32.0 bits (71), Expect = 2.2
Identities = 15/39 (38%), Positives = 22/39 (56%)
Query: 451 FVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET 489
+ + TFA S TE +LEI +A + T KW+D+ T
Sbjct: 2192 YERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWT 2230
>gi|4557793 neurofibromin isoform 2 [Homo sapiens]
Length = 2818
Score = 32.0 bits (71), Expect = 2.2
Identities = 15/39 (38%), Positives = 22/39 (56%)
Query: 451 FVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEET 489
+ + TFA S TE +LEI +A + T KW+D+ T
Sbjct: 2171 YERETFALTSLETVTEALLEIMEACMRDIPTCKWLDQWT 2209
>gi|134152674 rabaptin, RAB GTPase binding effector protein 1
isoform 2 [Homo sapiens]
Length = 829
Score = 31.6 bits (70), Expect = 2.9
Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 8/91 (8%)
Query: 406 LDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIAT 465
L+Q F KF E +Y K+ L R + +++LG ++ E+ K+IAT
Sbjct: 35 LEQEFNQKRAKFKE-LYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIAT 93
Query: 466 -------EIILEIKKAFEESLSTLKWMDEET 489
E I E+K+ + E +++L+ + +ET
Sbjct: 94 VSENTKQEAIDEVKRQWREEVASLQAVMKET 124
>gi|31377798 rabaptin, RAB GTPase binding effector protein 1 isoform
1 [Homo sapiens]
Length = 862
Score = 31.6 bits (70), Expect = 2.9
Identities = 25/91 (27%), Positives = 45/91 (49%), Gaps = 8/91 (8%)
Query: 406 LDQRFQDADEKFMEVMYGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIAT 465
L+Q F KF E +Y K+ L R + +++LG ++ E+ K+IAT
Sbjct: 35 LEQEFNQKRAKFKE-LYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIAT 93
Query: 466 -------EIILEIKKAFEESLSTLKWMDEET 489
E I E+K+ + E +++L+ + +ET
Sbjct: 94 VSENTKQEAIDEVKRQWREEVASLQAVMKET 124
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 30.8 bits (68), Expect = 5.0
Identities = 15/41 (36%), Positives = 28/41 (68%), Gaps = 1/41 (2%)
Query: 458 EDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKAD 498
++S+S++TE+ +IK A+EESL L+ + E + +E +D
Sbjct: 1476 KESRSLSTELF-KIKNAYEESLDQLETLKRENKNLQQEISD 1515
>gi|154744870 zinc finger protein 574 [Homo sapiens]
Length = 896
Score = 30.4 bits (67), Expect = 6.5
Identities = 21/65 (32%), Positives = 32/65 (49%), Gaps = 7/65 (10%)
Query: 140 PDGHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPL 199
PD + +FSNLW+H K + A+V + +A+ + ET +E L PL
Sbjct: 825 PDCGKSYRSFSNLWKHR----KTHQQQHQAAVRQQLAEAEAAVGLAVMETAVEAL---PL 877
Query: 200 MELIE 204
+E IE
Sbjct: 878 VEAIE 882
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 30.0 bits (66), Expect = 8.5
Identities = 14/41 (34%), Positives = 28/41 (68%), Gaps = 1/41 (2%)
Query: 458 EDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKAD 498
++S+S++TE+ ++K A+EESL L+ + E + +E +D
Sbjct: 1476 KESRSLSTELF-KVKNAYEESLDHLETLKRENKNLQQEISD 1515
>gi|50345831 forkhead box J3 [Homo sapiens]
Length = 622
Score = 30.0 bits (66), Expect = 8.5
Identities = 15/49 (30%), Positives = 27/49 (55%), Gaps = 4/49 (8%)
Query: 469 LEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNM----IGYPNFIMDP 513
L + E SL+++ W+ + T ++A +K+DA N I N ++DP
Sbjct: 14 LRMTSELESSLTSMDWLPQLTMRAAIQKSDATQNAHGTGISKKNALLDP 62
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,512,990
Number of Sequences: 37866
Number of extensions: 1375284
Number of successful extensions: 3374
Number of sequences better than 10.0: 24
Number of HSP's better than 10.0 without gapping: 18
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3279
Number of HSP's gapped (non-prelim): 30
length of query: 770
length of database: 18,247,518
effective HSP length: 110
effective length of query: 660
effective length of database: 14,082,258
effective search space: 9294290280
effective search space used: 9294290280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.