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Search of human proteins with 4503427
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 1 [Homo sapiens]
(528 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 1078 0.0
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 1078 0.0
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 687 0.0
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 687 0.0
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 437 e-122
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 283 4e-76
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 281 1e-75
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 277 2e-74
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 277 2e-74
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 277 2e-74
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 277 2e-74
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 277 2e-74
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 274 2e-73
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 213 5e-55
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 213 5e-55
gi|10190706 CDC-like kinase 4 [Homo sapiens] 206 6e-53
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 204 2e-52
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 204 2e-52
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 200 3e-51
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 200 3e-51
gi|47717134 CDC-like kinase 2 [Homo sapiens] 198 1e-50
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 197 2e-50
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 197 2e-50
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 192 5e-49
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 192 5e-49
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 179 4e-45
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 173 4e-43
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 150 3e-36
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 150 3e-36
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens] 146 5e-35
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 1078 bits (2788), Expect = 0.0
Identities = 528/528 (100%), Positives = 528/528 (100%)
Query: 1 MNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRR 60
MNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRR
Sbjct: 74 MNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRR 133
Query: 61 QGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQG 120
QGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQG
Sbjct: 134 QGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQG 193
Query: 121 MTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMV 180
MTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMV
Sbjct: 194 MTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMV 253
Query: 181 RNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIK 240
RNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIK
Sbjct: 254 RNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIK 313
Query: 241 KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC 300
KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC
Sbjct: 314 KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC 373
Query: 301 YEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLAC 360
YEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLAC
Sbjct: 374 YEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLAC 433
Query: 361 MIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPES 420
MIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPES
Sbjct: 434 MIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPES 493
Query: 421 REWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRI 480
REWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRI
Sbjct: 494 REWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRI 553
Query: 481 TESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS 528
TESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS
Sbjct: 554 TESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS 601
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 1078 bits (2788), Expect = 0.0
Identities = 528/528 (100%), Positives = 528/528 (100%)
Query: 1 MNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRR 60
MNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRR
Sbjct: 1 MNDHLHVGSHAHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRR 60
Query: 61 QGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQG 120
QGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQG
Sbjct: 61 QGSSTSLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQG 120
Query: 121 MTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMV 180
MTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMV
Sbjct: 121 MTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMV 180
Query: 181 RNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIK 240
RNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIK
Sbjct: 181 RNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIK 240
Query: 241 KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC 300
KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC
Sbjct: 241 KNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSC 300
Query: 301 YEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLAC 360
YEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLAC
Sbjct: 301 YEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLAC 360
Query: 361 MIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPES 420
MIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPES
Sbjct: 361 MIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPES 420
Query: 421 REWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRI 480
REWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRI
Sbjct: 421 REWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPPTGEKTSVKRI 480
Query: 481 TESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS 528
TESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS
Sbjct: 481 TESTGAITSISKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS 528
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 687 bits (1772), Expect = 0.0
Identities = 338/518 (65%), Positives = 411/518 (79%), Gaps = 12/518 (2%)
Query: 13 GQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEG 72
G+++V+QLF++ N+++ T Q +G++ K V + D ++ + +S+S
Sbjct: 61 GEMKVEQLFQEFGNRKSN-TIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAP--- 116
Query: 73 MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDD 132
K P+TPEQA+KQY LTA+E EI +YPEIYF+G NAKKR G+ GGPNNGGYDD
Sbjct: 117 ----KVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDD 172
Query: 133 DQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAE 192
G+Y+ VP DH+AYRYEVLK+IGKGSFGQV + YDHK+ Q+VALKMVRNEKRFHRQAAE
Sbjct: 173 ADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE 232
Query: 193 EIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLV 252
EIRILEHL+KQDK +MNVIHMLE+FTFRNH+CM FELLS++LYELIKKNKFQGFS+ LV
Sbjct: 233 EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLV 292
Query: 253 RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQS 312
RKFA SILQ LDALHKN+IIHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQS
Sbjct: 293 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS 352
Query: 313 RFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKL 372
RFYRAPE+ILG+RY PID+WS GCILAELLTG PL PGEDEGDQLACM+ELLGMP KL
Sbjct: 353 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 412
Query: 373 LDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD 432
L+ SKRAK F++SKG PRYC+VTT +DG VVL GGRSRRGK RGPP S++WG ALKGCDD
Sbjct: 413 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 472
Query: 433 PLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP-PTGEKTSVKRITESTGAITSI- 490
LF++FLK+CL WDP+ R+TP QALRHPW+ + +P+P T +K S KR+ A +
Sbjct: 473 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLG 532
Query: 491 SKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS 528
SKLPP A+KL+ NL M++ NG+I +VLPKL+S
Sbjct: 533 SKLPPVVGIANKLKANL--MSETNGSIPLCSVLPKLIS 568
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 687 bits (1772), Expect = 0.0
Identities = 338/518 (65%), Positives = 411/518 (79%), Gaps = 12/518 (2%)
Query: 13 GQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSSTSLKSMEG 72
G+++V+QLF++ N+++ T Q +G++ K V + D ++ + +S+S
Sbjct: 81 GEMKVEQLFQEFGNRKSN-TIQSDGISDSEKCSPTVSQGKSSDCLNTVKSNSSSKAP--- 136
Query: 73 MGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNNGGYDD 132
K P+TPEQA+KQY LTA+E EI +YPEIYF+G NAKKR G+ GGPNNGGYDD
Sbjct: 137 ----KVVPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGVIGGPNNGGYDD 192
Query: 133 DQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAE 192
G+Y+ VP DH+AYRYEVLK+IGKGSFGQV + YDHK+ Q+VALKMVRNEKRFHRQAAE
Sbjct: 193 ADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAE 252
Query: 193 EIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLV 252
EIRILEHL+KQDK +MNVIHMLE+FTFRNH+CM FELLS++LYELIKKNKFQGFS+ LV
Sbjct: 253 EIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLV 312
Query: 253 RKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQS 312
RKFA SILQ LDALHKN+IIHCDLKPENILLK GRS KVIDFGSSC+E+Q++YTYIQS
Sbjct: 313 RKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCFEYQKLYTYIQS 372
Query: 313 RFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKL 372
RFYRAPE+ILG+RY PID+WS GCILAELLTG PL PGEDEGDQLACM+ELLGMP KL
Sbjct: 373 RFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL 432
Query: 373 LDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDD 432
L+ SKRAK F++SKG PRYC+VTT +DG VVL GGRSRRGK RGPP S++WG ALKGCDD
Sbjct: 433 LEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWGTALKGCDD 492
Query: 433 PLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP-PTGEKTSVKRITESTGAITSI- 490
LF++FLK+CL WDP+ R+TP QALRHPW+ + +P+P T +K S KR+ A +
Sbjct: 493 YLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASAFQGLG 552
Query: 491 SKLPPPSSSASKLRTNLAQMTDANGNIQQRTVLPKLVS 528
SKLPP A+KL+ NL M++ NG+I +VLPKL+S
Sbjct: 553 SKLPPVVGIANKLKANL--MSETNGSIPLCSVLPKLIS 588
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 437 bits (1124), Expect = e-122
Identities = 219/414 (52%), Positives = 290/414 (70%), Gaps = 22/414 (5%)
Query: 68 KSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNN 127
K+ E K + +T +A+K + +L+ +E EI Y E++FLGL AKK +
Sbjct: 23 KAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSK 82
Query: 128 GGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFH 187
+DD+ G Y++V HDH+AYRYEVL+ IGKGSFGQV K DHK ++ VALK++RN+KRFH
Sbjct: 83 TSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFH 142
Query: 188 RQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGF 247
+QA E++ILE LRK+DKDNT NV+HM + F FRNH C+TFELL +NLYEL+K N FQGF
Sbjct: 143 QQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGF 202
Query: 248 SLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVY 307
SL +VR+F S+L+CL L +IIHCDLKPENI+L Q+G++ +KVIDFGSSCYEHQ+VY
Sbjct: 203 SLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVY 262
Query: 308 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 367
TYIQSRFYR+PEVILG Y + IDMWSLGCI AEL TGYPL PGE+E +QLAC++E+LG+
Sbjct: 263 TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGL 322
Query: 368 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNAL 427
P + + R + F SKG+P+ T + RGK R P+S++ L
Sbjct: 323 PPAGFIQTASRRQTFFDSKGFPKNIT---------------NNRGKKR-YPDSKDLTMVL 366
Query: 428 KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR-----RRLPKPPTGEKTS 476
K D FLDFL++CL W+P++RMTP QAL+H W+ + P+P T K++
Sbjct: 367 KTYDTS-FLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSN 419
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 283 bits (723), Expect = 4e-76
Identities = 168/398 (42%), Positives = 229/398 (57%), Gaps = 23/398 (5%)
Query: 127 NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRF 186
N GYDDD Y+ + RYE+ +IGKGSFGQVVKAYDH+ + VA+K+++N+K F
Sbjct: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
Query: 187 HRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG 246
QA E+R+LE + + D + ++H+ +F FRNH+C+ FELLS NLY+L++ F+G
Sbjct: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
Query: 247 FSLPLVRKFAHSILQCLD--ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ 304
SL L RK A + L A + IIHCDLKPENILL RS IK++DFGSSC Q
Sbjct: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
Query: 305 RVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIEL 364
R+Y YIQSRFYR+PEV+LG Y + IDMWSLGCIL E+ TG PL G +E DQ+ ++E+
Sbjct: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
Query: 365 LGMPSQKLLDASKRAKNF---VSSKGYPRYCTVTTLSDGSVVLNGGRSRR-----GKLRG 416
LG+P +LD + +A+ + + G+ T D G +RR G G
Sbjct: 329 LGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKD----YQGPGTRRLQEVLGVQTG 384
Query: 417 PPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP----PT 471
P R G D L F D + + LE++PA R++P AL+H + RR + P
Sbjct: 385 GPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPA 444
Query: 472 GEKTSVK----RITESTGAITSISKLPPPSSSASKLRT 505
G S S+ +SIS S S+S RT
Sbjct: 445 GSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRT 482
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 281 bits (719), Expect = 1e-75
Identities = 162/389 (41%), Positives = 222/389 (57%), Gaps = 33/389 (8%)
Query: 127 NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRF 186
N GYDDD Y+ + RYE+ +IGKGSFGQVVKAYDH+ + VA+K+++N+K F
Sbjct: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
Query: 187 HRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG 246
QA E+R+LE + + D + ++H+ +F FRNH+C+ FELLS NLY+L++ F+G
Sbjct: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
Query: 247 FSLPLVRKFAHSILQCLD--ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ 304
SL L RK A + L A + IIHCDLKPENILL RS IK++DFGSSC Q
Sbjct: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
Query: 305 RVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIEL 364
R+Y YIQSRFYR+PEV+LG Y + IDMWSLGCIL E+ TG PL G +E DQ+ ++E+
Sbjct: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
Query: 365 LGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWG 424
LG+P +LD + +A+ + L G L + R +GP R
Sbjct: 329 LGIPPAAMLDQAPKARKYFE-----------RLPGGGWTLRRTKELRKDYQGPGTRR--- 374
Query: 425 NALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP----PTGEKTSVK-- 478
L D + + LE++PA R++P AL+H + RR + P G S
Sbjct: 375 ---------LQEDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPA 425
Query: 479 --RITESTGAITSISKLPPPSSSASKLRT 505
S+ +SIS S S+S RT
Sbjct: 426 PLDTCPSSSTASSISSSGGSSGSSSDNRT 454
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 277 bits (708), Expect = 2e-74
Identities = 164/416 (39%), Positives = 228/416 (54%), Gaps = 31/416 (7%)
Query: 107 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 158
E+Y+ + +QG + N GYDDD Y+ + RYE+ +IGKG
Sbjct: 109 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 168
Query: 159 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 218
SFGQVVKAYD + VA+K+++N+K F QA E+R+LE + K D + ++H+ +F
Sbjct: 169 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 228
Query: 219 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 276
FRNH+C+ FE+LS NLY+L++ F+G SL L RKFA + L A + IIHCDL
Sbjct: 229 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
Query: 277 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 336
KPENILL RS IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y + IDMWSLG
Sbjct: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 348
Query: 337 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 396
CIL E+ TG PL G +E DQ+ ++E+LG+P +LD + +A+ F + +
Sbjct: 349 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 407
Query: 397 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 450
DG +R+ G G P R G + D L F D + + L++DP R
Sbjct: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
Query: 451 MTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTN 506
+ P AL+H + + K E T S+S P S S T+
Sbjct: 468 IQPYYALQHSFFK--------------KTADEGTNTSNSVSTSPAMEQSQSSGTTS 509
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 277 bits (708), Expect = 2e-74
Identities = 164/416 (39%), Positives = 228/416 (54%), Gaps = 31/416 (7%)
Query: 107 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 158
E+Y+ + +QG + N GYDDD Y+ + RYE+ +IGKG
Sbjct: 109 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 168
Query: 159 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 218
SFGQVVKAYD + VA+K+++N+K F QA E+R+LE + K D + ++H+ +F
Sbjct: 169 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 228
Query: 219 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 276
FRNH+C+ FE+LS NLY+L++ F+G SL L RKFA + L A + IIHCDL
Sbjct: 229 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
Query: 277 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 336
KPENILL RS IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y + IDMWSLG
Sbjct: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 348
Query: 337 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 396
CIL E+ TG PL G +E DQ+ ++E+LG+P +LD + +A+ F + +
Sbjct: 349 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 407
Query: 397 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 450
DG +R+ G G P R G + D L F D + + L++DP R
Sbjct: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
Query: 451 MTPGQALRHPWLRRRLPKPPTGEKTSVKRITESTGAITSISKLPPPSSSASKLRTN 506
+ P AL+H + + K E T S+S P S S T+
Sbjct: 468 IQPYYALQHSFFK--------------KTADEGTNTSNSVSTSPAMEQSQSSGTTS 509
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 277 bits (708), Expect = 2e-74
Identities = 165/416 (39%), Positives = 233/416 (56%), Gaps = 23/416 (5%)
Query: 107 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 158
E+Y+ + +QG + N GYDDD Y+ + RYE+ +IGKG
Sbjct: 109 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 168
Query: 159 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 218
SFGQVVKAYD + VA+K+++N+K F QA E+R+LE + K D + ++H+ +F
Sbjct: 169 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 228
Query: 219 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 276
FRNH+C+ FE+LS NLY+L++ F+G SL L RKFA + L A + IIHCDL
Sbjct: 229 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
Query: 277 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 336
KPENILL RS IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y + IDMWSLG
Sbjct: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 348
Query: 337 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 396
CIL E+ TG PL G +E DQ+ ++E+LG+P +LD + +A+ F + +
Sbjct: 349 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 407
Query: 397 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 450
DG +R+ G G P R G + D L F D + + L++DP R
Sbjct: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
Query: 451 MTPGQALRHPWLRRRLPKPPTGEKTSVK-----RITESTGAITSISKLPPPSSSAS 501
+ P AL+H + ++ + T SV ++S+G +S S SS S
Sbjct: 468 IQPYYALQHSFFKKTADE-GTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTS 522
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 277 bits (708), Expect = 2e-74
Identities = 165/416 (39%), Positives = 233/416 (56%), Gaps = 23/416 (5%)
Query: 107 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 158
E+Y+ + +QG + N GYDDD Y+ + RYE+ +IGKG
Sbjct: 100 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 159
Query: 159 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 218
SFGQVVKAYD + VA+K+++N+K F QA E+R+LE + K D + ++H+ +F
Sbjct: 160 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 219
Query: 219 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 276
FRNH+C+ FE+LS NLY+L++ F+G SL L RKFA + L A + IIHCDL
Sbjct: 220 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 279
Query: 277 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 336
KPENILL RS IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y + IDMWSLG
Sbjct: 280 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 339
Query: 337 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 396
CIL E+ TG PL G +E DQ+ ++E+LG+P +LD + +A+ F + +
Sbjct: 340 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 398
Query: 397 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 450
DG +R+ G G P R G + D L F D + + L++DP R
Sbjct: 399 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 458
Query: 451 MTPGQALRHPWLRRRLPKPPTGEKTSVK-----RITESTGAITSISKLPPPSSSAS 501
+ P AL+H + ++ + T SV ++S+G +S S SS S
Sbjct: 459 IQPYYALQHSFFKKTADE-GTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTS 513
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 277 bits (708), Expect = 2e-74
Identities = 165/416 (39%), Positives = 233/416 (56%), Gaps = 23/416 (5%)
Query: 107 EIYFLGLNAKKRQGMTGGPN--------NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKG 158
E+Y+ + +QG + N GYDDD Y+ + RYE+ +IGKG
Sbjct: 109 EVYYAKKKRRHQQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKG 168
Query: 159 SFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENF 218
SFGQVVKAYD + VA+K+++N+K F QA E+R+LE + K D + ++H+ +F
Sbjct: 169 SFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHF 228
Query: 219 TFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLD--ALHKNRIIHCDL 276
FRNH+C+ FE+LS NLY+L++ F+G SL L RKFA + L A + IIHCDL
Sbjct: 229 MFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDL 288
Query: 277 KPENILLKQQGRSGIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLG 336
KPENILL RS IK++DFGSSC QR+Y YIQSRFYR+PEV+LG Y + IDMWSLG
Sbjct: 289 KPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLG 348
Query: 337 CILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTT 396
CIL E+ TG PL G +E DQ+ ++E+LG+P +LD + +A+ F + +
Sbjct: 349 CILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTW-NLKK 407
Query: 397 LSDGSVVLNGGRSRR-----GKLRGPPESREWGNALKGCDDPL-FLDFLKQCLEWDPAVR 450
DG +R+ G G P R G + D L F D + + L++DP R
Sbjct: 408 TKDGKREYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTR 467
Query: 451 MTPGQALRHPWLRRRLPKPPTGEKTSVK-----RITESTGAITSISKLPPPSSSAS 501
+ P AL+H + ++ + T SV ++S+G +S S SS S
Sbjct: 468 IQPYYALQHSFFKKTADE-GTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTS 522
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 274 bits (700), Expect = 2e-73
Identities = 161/389 (41%), Positives = 220/389 (56%), Gaps = 45/389 (11%)
Query: 127 NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRF 186
N GYDDD Y+ + RYE+ +IGKGSFGQVVKAYDH+ + VA+K+++N+K F
Sbjct: 89 NHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAF 148
Query: 187 HRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQG 246
QA E+R+LE + + D + ++H+ +F FRNH+C+ FELLS NLY+L++ F+G
Sbjct: 149 LNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRG 208
Query: 247 FSLPLVRKFAHSILQCLD--ALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQ 304
SL L RK A + L A + IIHCDLKPENILL RS IK++DFGSSC Q
Sbjct: 209 VSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQ 268
Query: 305 RVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIEL 364
R+Y YIQSRFYR+PEV+LG Y + IDMWSLGCIL E+ TG PL G +E DQ+ ++E+
Sbjct: 269 RIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEV 328
Query: 365 LGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWG 424
LG+P +LD + +A+ + L GG LR E R+
Sbjct: 329 LGIPPAAMLDQAPKARKYFER------------------LPGG---GWTLRRTKELRK-- 365
Query: 425 NALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKP----PTGEKTSVK-- 478
D + + LE++PA R++P AL+H + RR + P G S
Sbjct: 366 ------------DLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPA 413
Query: 479 --RITESTGAITSISKLPPPSSSASKLRT 505
S+ +SIS S S+S RT
Sbjct: 414 PLDTCPSSSTASSISSSGGSSGSSSDNRT 442
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 213 bits (541), Expect = 5e-55
Identities = 126/351 (35%), Positives = 193/351 (54%), Gaps = 37/351 (10%)
Query: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 189
DD++G + D ++ RYE++ +G+G+FG+VV+ DHK +HVA+K+V+N R+
Sbjct: 185 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 244
Query: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249
A EI++LEHL D ++T + MLE F HIC+ FELL ++ Y+ IK+N F F L
Sbjct: 245 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 304
Query: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG-----------------RSGIK 292
+RK A+ I + ++ LH N++ H DLKPENIL Q IK
Sbjct: 305 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 364
Query: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352
V+DFGS+ Y+ + T + +R YRAPEVIL + P D+WS+GCIL E G+ + P
Sbjct: 365 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 424
Query: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGR--SR 410
D + LA M +LG + ++ +++ K F + D + GR SR
Sbjct: 425 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDR-----------LDWDEHSSAGRYVSR 473
Query: 411 RGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPW 461
R K +E+ + + LF D +++ LE+DPA R+T +AL+HP+
Sbjct: 474 RCK-----PLKEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 518
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 213 bits (541), Expect = 5e-55
Identities = 126/351 (35%), Positives = 193/351 (54%), Gaps = 37/351 (10%)
Query: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 189
DD++G + D ++ RYE++ +G+G+FG+VV+ DHK +HVA+K+V+N R+
Sbjct: 143 DDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEA 202
Query: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249
A EI++LEHL D ++T + MLE F HIC+ FELL ++ Y+ IK+N F F L
Sbjct: 203 ARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRL 262
Query: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQG-----------------RSGIK 292
+RK A+ I + ++ LH N++ H DLKPENIL Q IK
Sbjct: 263 DHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIK 322
Query: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352
V+DFGS+ Y+ + T + +R YRAPEVIL + P D+WS+GCIL E G+ + P
Sbjct: 323 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTH 382
Query: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGR--SR 410
D + LA M +LG + ++ +++ K F + D + GR SR
Sbjct: 383 DSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDR-----------LDWDEHSSAGRYVSR 431
Query: 411 RGKLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPW 461
R K +E+ + + LF D +++ LE+DPA R+T +AL+HP+
Sbjct: 432 RCK-----PLKEFMLSQDVEHERLF-DLIQKMLEYDPAKRITLREALKHPF 476
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 206 bits (523), Expect = 6e-53
Identities = 119/352 (33%), Positives = 188/352 (53%), Gaps = 39/352 (11%)
Query: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 189
DD++G + D + RYE++ +G+G+FG+VV+ DH + HVA+K+V+N R+
Sbjct: 141 DDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREA 200
Query: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249
A EI++LEHL D ++ + MLE F H+C+ FELL ++ Y+ IK+N F F +
Sbjct: 201 ARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQI 260
Query: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENIL-------------LKQQGR----SGIK 292
+R+ A+ I Q ++ LH N++ H DLKPENIL +K+ R + IK
Sbjct: 261 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 320
Query: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352
V+DFGS+ Y+ + T + +R YRAPEVIL + P D+WS+GCIL E G+ +
Sbjct: 321 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTH 380
Query: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412
D + LA M +LG Q ++ +++ K F ++ D + GR R
Sbjct: 381 DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQ-----------LDWDEHSSAGRYVRR 429
Query: 413 KLRGPPESREWGNALKGCDD---PLFLDFLKQCLEWDPAVRMTPGQALRHPW 461
+ + E C D D +++ LE+DP R+T +AL+HP+
Sbjct: 430 RCKPLKE-------FMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPF 474
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 204 bits (518), Expect = 2e-52
Identities = 126/362 (34%), Positives = 189/362 (52%), Gaps = 25/362 (6%)
Query: 122 TGGPNNGGYDDDQGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALK 178
T N G + +G Y V H+ + YEVL+ +G+G+FGQVVK + ++ VA+K
Sbjct: 170 TATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIK 228
Query: 179 MVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYEL 238
+++N + RQ E+ IL L + D+ N + E F +NH C+ FE+L NLY+
Sbjct: 229 ILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDF 287
Query: 239 IKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDF 296
+K+NKF L +R + L L +IH DLKPENI+L R +KVIDF
Sbjct: 288 LKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDF 347
Query: 297 GSSCYEHQRVY-TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEG 355
GS+ + + V TY+QSR+YRAPE+ILG + IDMWSLGC++AEL G+PL PG E
Sbjct: 348 GSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEY 407
Query: 356 DQLACMIELLGMPSQKLLDASKRAKNFV---SSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412
DQ+ + + G+P++ LL A + F + YP + T D G +S+
Sbjct: 408 DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT--PDDHEAETGIKSKEA 465
Query: 413 K------------LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHP 460
+ + + ++ D F+D LK+ L D R+TP + L HP
Sbjct: 466 RKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHP 525
Query: 461 WL 462
++
Sbjct: 526 FV 527
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 204 bits (518), Expect = 2e-52
Identities = 126/362 (34%), Positives = 189/362 (52%), Gaps = 25/362 (6%)
Query: 122 TGGPNNGGYDDDQGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALK 178
T N G + +G Y V H+ + YEVL+ +G+G+FGQVVK + ++ VA+K
Sbjct: 170 TATSKNSG-SNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIK 228
Query: 179 MVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYEL 238
+++N + RQ E+ IL L + D+ N + E F +NH C+ FE+L NLY+
Sbjct: 229 ILKNHPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDF 287
Query: 239 IKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDF 296
+K+NKF L +R + L L +IH DLKPENI+L R +KVIDF
Sbjct: 288 LKQNKFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDF 347
Query: 297 GSSCYEHQRVY-TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEG 355
GS+ + + V TY+QSR+YRAPE+ILG + IDMWSLGC++AEL G+PL PG E
Sbjct: 348 GSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEY 407
Query: 356 DQLACMIELLGMPSQKLLDASKRAKNFV---SSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412
DQ+ + + G+P++ LL A + F + YP + T D G +S+
Sbjct: 408 DQIRYISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKT--PDDHEAETGIKSKEA 465
Query: 413 K------------LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHP 460
+ + + ++ D F+D LK+ L D R+TP + L HP
Sbjct: 466 RKYIFNCLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHP 525
Query: 461 WL 462
++
Sbjct: 526 FV 527
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 200 bits (508), Expect = 3e-51
Identities = 124/359 (34%), Positives = 188/359 (52%), Gaps = 36/359 (10%)
Query: 134 QGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA 190
+G Y V H+ + YEVL +G+G+FGQVVK + ++ VA+K+++N + RQ
Sbjct: 179 EGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 238
Query: 191 AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP 250
E+ IL L ++ D N + E F RNH C+ FE+L NLY+ +K+NKF L
Sbjct: 239 QIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297
Query: 251 LVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY- 307
++R + L L +IH DLKPENI+L R +KVIDFGS+ + + V
Sbjct: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357
Query: 308 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 367
TY+QSR+YRAPE+ILG + IDMWSLGC++AEL G+PL PG E DQ+ + + G+
Sbjct: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417
Query: 368 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL-RGPPESREW--- 423
P ++LL+ ++ F +C T +S L + E+R++
Sbjct: 418 PGEQLLNVGTKSTRF--------FCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFN 469
Query: 424 ---------------GNAL--KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 465
G+ L + D F+ LK+ L D +R+TP + L HP++ +
Sbjct: 470 SLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMK 528
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 200 bits (508), Expect = 3e-51
Identities = 124/359 (34%), Positives = 188/359 (52%), Gaps = 36/359 (10%)
Query: 134 QGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA 190
+G Y V H+ + YEVL +G+G+FGQVVK + ++ VA+K+++N + RQ
Sbjct: 179 EGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQG 238
Query: 191 AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP 250
E+ IL L ++ D N + E F RNH C+ FE+L NLY+ +K+NKF L
Sbjct: 239 QIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 297
Query: 251 LVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY- 307
++R + L L +IH DLKPENI+L R +KVIDFGS+ + + V
Sbjct: 298 VIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCS 357
Query: 308 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 367
TY+QSR+YRAPE+ILG + IDMWSLGC++AEL G+PL PG E DQ+ + + G+
Sbjct: 358 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGL 417
Query: 368 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKL-RGPPESREW--- 423
P ++LL+ ++ F +C T +S L + E+R++
Sbjct: 418 PGEQLLNVGTKSTRF--------FCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFN 469
Query: 424 ---------------GNAL--KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRR 465
G+ L + D F+ LK+ L D +R+TP + L HP++ +
Sbjct: 470 SLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMK 528
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 198 bits (503), Expect = 1e-50
Identities = 113/358 (31%), Positives = 185/358 (51%), Gaps = 33/358 (9%)
Query: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 189
DD +G + D + RYE++ +G+G+FG+VV+ DH+ VALK+++N +++
Sbjct: 144 DDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEA 203
Query: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249
A EI +LE + ++D DN + M + F + H+C++FELL ++ ++ +K N + + +
Sbjct: 204 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPI 263
Query: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILL-------------KQQGRS----GIK 292
VR A + Q + LH N++ H DLKPENIL K+ RS ++
Sbjct: 264 HQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVR 323
Query: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352
V+DFGS+ ++H+ T + +R YRAPEVIL + P D+WS+GCI+ E G+ L
Sbjct: 324 VVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTH 383
Query: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412
D + LA M +LG +++ +++ K F R S G V + R
Sbjct: 384 DNREHLAMMERILGPIPSRMIRKTRKQKYFYRG----RLDWDENTSAGRYVRENCKPLRR 439
Query: 413 KLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP 470
L E D ++ LE++PA R+T G+AL+HP+ R +PP
Sbjct: 440 YLTSEAEEHH-----------QLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPP 486
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 197 bits (501), Expect = 2e-50
Identities = 120/350 (34%), Positives = 184/350 (52%), Gaps = 24/350 (6%)
Query: 134 QGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA 190
+G Y V H+ + YEVL+ +G+G+FGQV K + + VA+K+++N + RQ
Sbjct: 172 EGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQG 231
Query: 191 AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP 250
E+ IL L ++ D N + E F +NH C+ FE+L NLY+ +K+NKF L
Sbjct: 232 QIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290
Query: 251 LVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY- 307
+R + L L +IH DLKPENI+L R +KVIDFGS+ + + V
Sbjct: 291 YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCS 350
Query: 308 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 367
TY+QSR+YRAPE+ILG + IDMWSLGC++AEL G+PL PG E DQ+ + + G+
Sbjct: 351 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410
Query: 368 PSQKLLDASKRAKNFVS---SKGYPRYCTVTTLSDGSVVLNGGRSRRGK----------- 413
P++ LL A + F + + GYP + T + + G +S+ +
Sbjct: 411 PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKT--PEEHELETGIKSKEARKYIFNCLDDMA 468
Query: 414 -LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 462
+ + + D ++D LK+ L D R+TP + L H ++
Sbjct: 469 QVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV 518
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 197 bits (501), Expect = 2e-50
Identities = 120/350 (34%), Positives = 184/350 (52%), Gaps = 24/350 (6%)
Query: 134 QGSYVQVPHD---HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQA 190
+G Y V H+ + YEVL+ +G+G+FGQV K + + VA+K+++N + RQ
Sbjct: 172 EGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQG 231
Query: 191 AEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLP 250
E+ IL L ++ D N + E F +NH C+ FE+L NLY+ +K+NKF L
Sbjct: 232 QIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLK 290
Query: 251 LVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVY- 307
+R + L L +IH DLKPENI+L R +KVIDFGS+ + + V
Sbjct: 291 YIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKAVCS 350
Query: 308 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 367
TY+QSR+YRAPE+ILG + IDMWSLGC++AEL G+PL PG E DQ+ + + G+
Sbjct: 351 TYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410
Query: 368 PSQKLLDASKRAKNFVS---SKGYPRYCTVTTLSDGSVVLNGGRSRRGK----------- 413
P++ LL A + F + + GYP + T + + G +S+ +
Sbjct: 411 PAEYLLSAGTKTTRFFNRDPNLGYPLWRLKT--PEEHELETGIKSKEARKYIFNCLDDMA 468
Query: 414 -LRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 462
+ + + D ++D LK+ L D R+TP + L H ++
Sbjct: 469 QVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV 518
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 192 bits (489), Expect = 5e-49
Identities = 116/356 (32%), Positives = 184/356 (51%), Gaps = 33/356 (9%)
Query: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDH-KVHQHVALKMVRNEKRFHRQ 189
DD +G V D + RYE++ +G+G+FG+VV+ DH + VALK++RN ++
Sbjct: 286 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 345
Query: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249
A EI +L+ ++++DK+N + M + F F H+C+ FELL N +E +K+N FQ + L
Sbjct: 346 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 405
Query: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILL-----------------KQQGRSGIK 292
P VR A+ + L LH+N++ H DLKPENIL K + I+
Sbjct: 406 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 465
Query: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352
V DFGS+ ++H+ T + +R YR PEVIL + P D+WS+GCIL E G+ L
Sbjct: 466 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 525
Query: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412
+ + L M ++LG ++ +++ K F SDG V +
Sbjct: 526 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKG----GLVWDENSSDGRYVKENCK---- 577
Query: 413 KLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPK 468
P +S ++L+ D +++ LE+DPA R+T +AL HP+ P+
Sbjct: 578 ----PLKSYMLQDSLEHVQ---LFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE 626
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 192 bits (489), Expect = 5e-49
Identities = 116/356 (32%), Positives = 184/356 (51%), Gaps = 33/356 (9%)
Query: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDH-KVHQHVALKMVRNEKRFHRQ 189
DD +G V D + RYE++ +G+G+FG+VV+ DH + VALK++RN ++
Sbjct: 138 DDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA 197
Query: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249
A EI +L+ ++++DK+N + M + F F H+C+ FELL N +E +K+N FQ + L
Sbjct: 198 ARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPL 257
Query: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENILL-----------------KQQGRSGIK 292
P VR A+ + L LH+N++ H DLKPENIL K + I+
Sbjct: 258 PHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIR 317
Query: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352
V DFGS+ ++H+ T + +R YR PEVIL + P D+WS+GCIL E G+ L
Sbjct: 318 VADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTH 377
Query: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412
+ + L M ++LG ++ +++ K F SDG V +
Sbjct: 378 ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKG----GLVWDENSSDGRYVKENCK---- 429
Query: 413 KLRGPPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRRRLPK 468
P +S ++L+ D +++ LE+DPA R+T +AL HP+ P+
Sbjct: 430 ----PLKSYMLQDSLEHVQ---LFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPE 478
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 179 bits (455), Expect = 4e-45
Identities = 116/343 (33%), Positives = 175/343 (51%), Gaps = 35/343 (10%)
Query: 149 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT 208
Y++++V+GKG+FG+V K + + VA+K+++N+ +R E+++L +R D +
Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Query: 209 MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK 268
+VI LE F + FELL NL+E K+N F +R +L L L +
Sbjct: 71 -HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKE 129
Query: 269 NRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVYT---YIQSRFYRAPEVILG 323
IIH DLKPENI+L Q R +KVIDFGS+ + Y YIQSRFYRAPE++LG
Sbjct: 130 LAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLG 189
Query: 324 ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFV 383
+ +D+WSLGC++AEL G+PL PG +E DQ+ + E G+P LL A+ +A +F
Sbjct: 190 LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFF 249
Query: 384 SSKGYPRYCTVTTLS------------------------DGSVVLNGGRSRRGKLRGPPE 419
+P L D +NGG S +L P
Sbjct: 250 KRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGG-SVASRLTFPDR 308
Query: 420 SREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 462
+ D ++ +K+ L W+ R++P ALRHP++
Sbjct: 309 EA----LAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV 347
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 173 bits (438), Expect = 4e-43
Identities = 128/422 (30%), Positives = 210/422 (49%), Gaps = 34/422 (8%)
Query: 66 SLKSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTG-- 123
++ + E K K MT EQ +KL A ++F+ + F R G
Sbjct: 599 NVDTFEASVKAKHNLMTVEQNNGSSQKKLLA---PDMFTESDDMFAAYFDSARLRAAGIG 655
Query: 124 -----GPN-NGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDH-KVHQHVA 176
PN + D +G Y + + RY V G+G F VV+A D+ + +Q VA
Sbjct: 656 KDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVA 715
Query: 177 LKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLY 236
+K++RN + + +E+ L+ L D D+ + + + +F + H+C+ FE LSMNL
Sbjct: 716 VKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLR 775
Query: 237 ELIKK-NKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVID 295
E++KK K G + VR ++ + L L + I+H D+KP+NIL+ + ++ +K+ D
Sbjct: 776 EVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES-KTILKLCD 834
Query: 296 FGSSCYEHQRVYT-YIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDE 354
FGS+ + T Y+ SRFYRAPE+I+G Y IDMWS+GC L EL TG L PG+
Sbjct: 835 FGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTN 894
Query: 355 GDQLACMIELLG-MPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVV-----LNGGR 408
L ++L G MP++ + + ++F + + Y V +++ V +N +
Sbjct: 895 NHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNF-MYIEVDKVTEREKVTVMSTINPTK 953
Query: 409 SRRGKLRG----PPESREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLRR 464
L G P + R+ + LK D L Q L DPA R++ QAL+H +++
Sbjct: 954 DLLADLIGCQRLPEDQRKKVHQLK--------DLLDQILMLDPAKRISINQALQHAFIQE 1005
Query: 465 RL 466
++
Sbjct: 1006 KI 1007
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 150 bits (379), Expect = 3e-36
Identities = 105/335 (31%), Positives = 174/335 (51%), Gaps = 41/335 (12%)
Query: 144 HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQ 203
+V ++E+L V+G+G++G V+K + H+ VA+K ++ + +R L+ LR
Sbjct: 8 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 67
Query: 204 DKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCL 263
++N ++ + E F R + + FE + N+ EL+++ G V+ + + +++ +
Sbjct: 68 KQEN---IVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAI 123
Query: 264 DALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS---CYEHQRVYT-YIQSRFYRAPE 319
HKN I+H D+KPEN+L+ +K+ DFG + + YT Y+ +R+YR+PE
Sbjct: 124 HWCHKNDIVHRDIKPENLLISHN--DVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181
Query: 320 VILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLG-MPSQKLLDASKR 378
++LGA YG +DMWS+GCIL EL G PL PGE E DQL + ++LG +PS+++
Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQM------ 235
Query: 379 AKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDF 438
K F S+ PR+ R P+S E G + + LD
Sbjct: 236 -KLFYSN---PRF----------------HGLRFPAVNHPQSLE--RRYLGILNSVLLDL 273
Query: 439 LKQCLEWDPAVRMTPGQALRHPWL--RRRLPKPPT 471
+K L+ DPA R Q L HP +R L + P+
Sbjct: 274 MKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 150 bits (379), Expect = 3e-36
Identities = 105/335 (31%), Positives = 174/335 (51%), Gaps = 41/335 (12%)
Query: 144 HVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQ 203
+V ++E+L V+G+G++G V+K + H+ VA+K ++ + +R L+ LR
Sbjct: 8 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 67
Query: 204 DKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCL 263
++N ++ + E F R + + FE + N+ EL+++ G V+ + + +++ +
Sbjct: 68 KQEN---IVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLIKAI 123
Query: 264 DALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSS---CYEHQRVYT-YIQSRFYRAPE 319
HKN I+H D+KPEN+L+ +K+ DFG + + YT Y+ +R+YR+PE
Sbjct: 124 HWCHKNDIVHRDIKPENLLISHN--DVLKLCDFGFARNLSEGNNANYTEYVATRWYRSPE 181
Query: 320 VILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLG-MPSQKLLDASKR 378
++LGA YG +DMWS+GCIL EL G PL PGE E DQL + ++LG +PS+++
Sbjct: 182 LLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQM------ 235
Query: 379 AKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLDF 438
K F S+ PR+ R P+S E G + + LD
Sbjct: 236 -KLFYSN---PRF----------------HGLRFPAVNHPQSLE--RRYLGILNSVLLDL 273
Query: 439 LKQCLEWDPAVRMTPGQALRHPWL--RRRLPKPPT 471
+K L+ DPA R Q L HP +R L + P+
Sbjct: 274 MKNLLKLDPADRYLTEQCLNHPTFQTQRLLDRSPS 308
>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
Length = 346
Score = 146 bits (368), Expect = 5e-35
Identities = 92/254 (36%), Positives = 145/254 (57%), Gaps = 19/254 (7%)
Query: 146 AYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKR------FHRQAAEEIRILEH 199
A RYE L +G+G F V KA D +Q VA+K ++ R +R A EI++L+
Sbjct: 9 AKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQE 68
Query: 200 LRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSI 259
L N+I +L+ F +++I + F+ + +L +IK N + ++ +
Sbjct: 69 LSHP------NIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLV-LTPSHIKAYMLMT 121
Query: 260 LQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFG--SSCYEHQRVYTY-IQSRFYR 316
LQ L+ LH++ I+H DLKP N+LL + G +K+ DFG S R YT+ + +R+YR
Sbjct: 122 LQGLEYLHQHWILHRDLKPNNLLLDENGV--LKLADFGLAKSFGSPNRAYTHQVVTRWYR 179
Query: 317 APEVILGAR-YGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDA 375
APE++ GAR YG+ +DMW++GCILAELL P LPG+ + DQL + E LG P+++
Sbjct: 180 APELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPD 239
Query: 376 SKRAKNFVSSKGYP 389
++V+ K +P
Sbjct: 240 MCSLPDYVTFKSFP 253
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,546,356
Number of Sequences: 37866
Number of extensions: 1049096
Number of successful extensions: 4927
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 541
Number of HSP's successfully gapped in prelim test: 224
Number of HSP's that attempted gapping in prelim test: 2819
Number of HSP's gapped (non-prelim): 1199
length of query: 528
length of database: 18,247,518
effective HSP length: 107
effective length of query: 421
effective length of database: 14,195,856
effective search space: 5976455376
effective search space used: 5976455376
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.