Search of human proteins with 4502277

Search of human proteins with 4502277

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4502277 Na+/K+ -ATPase beta 1 subunit isoform a [Homo
sapiens]
         (303 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4502277 Na+/K+ -ATPase beta 1 subunit isoform a [Homo sapiens]     635   0.0  
gi|49574489 Na+/K+ -ATPase beta 1 subunit isoform b [Homo sapiens]    629   0.0  
gi|49574491 Na+/K+ -ATPase beta 2 subunit [Homo sapiens]              211   5e-55
gi|215490093 ATPase, (Na+)/K+ transporting, beta 4 polypeptide i...   181   7e-46
gi|4502281 Na+/K+ -ATPase beta 3 subunit [Homo sapiens]               174   1e-43
gi|6912256 ATPase, (Na+)/K+ transporting, beta 4 polypeptide iso...   171   7e-43
gi|4557339 hydrogen/potassium-exchanging ATPase 4B [Homo sapiens]     150   2e-36
gi|20149698 l(3)mbt-like 2 [Homo sapiens]                              31   1.5  
gi|148612863 transient receptor potential cation channel, subfam...    31   1.5  
gi|14249528 solute carrier family 35, member B4 [Homo sapiens]         28   7.7  

>gi|4502277 Na+/K+ -ATPase beta 1 subunit isoform a [Homo sapiens]
          Length = 303

 Score =  635 bits (1639), Expect = 0.0
 Identities = 303/303 (100%), Positives = 303/303 (100%)

Query: 1   MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT 60
           MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT
Sbjct: 1   MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT 60

Query: 61  ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD 120
           ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD
Sbjct: 61  ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD 120

Query: 121 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL 180
           MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
Sbjct: 121 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL 180

Query: 181 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL 240
           NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL
Sbjct: 181 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL 240

Query: 241 QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE 300
           QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE
Sbjct: 241 QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE 300

Query: 301 VKS 303
           VKS
Sbjct: 301 VKS 303


>gi|49574489 Na+/K+ -ATPase beta 1 subunit isoform b [Homo sapiens]
          Length = 301

 Score =  629 bits (1622), Expect = 0.0
 Identities = 299/300 (99%), Positives = 300/300 (100%)

Query: 1   MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT 60
           MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT
Sbjct: 1   MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLT 60

Query: 61  ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD 120
           ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD
Sbjct: 61  ISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD 120

Query: 121 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL 180
           MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL
Sbjct: 121 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL 180

Query: 181 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL 240
           NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL
Sbjct: 181 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL 240

Query: 241 QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIE 300
           QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKI+
Sbjct: 241 QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIK 300


>gi|49574491 Na+/K+ -ATPase beta 2 subunit [Homo sapiens]
          Length = 290

 Score =  211 bits (538), Expect = 5e-55
 Identities = 118/302 (39%), Positives = 170/302 (56%), Gaps = 29/302 (9%)

Query: 4   GKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISE 63
           G+  EE  WK+F+WN    +F+GRTG SW  ILLFY++FYG L  +F  T+ VML T+S+
Sbjct: 11  GQVVEE--WKEFVWNPRTHQFMGRTGTSWAFILLFYLVFYGFLTAMFTLTMWVMLQTVSD 68

Query: 64  FKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDS--AQRDDM 121
             P YQDR+A PGL   P+ +  ++    +D +S++ +V  + +FLE Y DS  AQ++D+
Sbjct: 69  HTPKYQDRLATPGLMIRPKTENLDVIVNVSDTESWDQHVQKLNKFLEPYNDSIQAQKNDV 128

Query: 122 IFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDET-YGYKEGKPCIIIKL 180
                   P    E+ D       ++ C+F    LGNCSG+ D T YGY  G+PC+ IK+
Sbjct: 129 C------RPGRYYEQPDNGVLNYPKRACQFNRTQLGNCSGIGDSTHYGYSTGQPCVFIKM 182

Query: 181 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPL 240
           NRV+ F      N+S+              V C GKRDED + +GN   F    +    L
Sbjct: 183 NRVINF--YAGANQSMN-------------VTCAGKRDEDAENLGNFVMFPANGN--IDL 225

Query: 241 QYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGY-SEKDRFQGRFDVKI 299
            Y+PYYGK     Y QPL+AV+F N+T + E+ +EC+    NI    E+D+F GR   K+
Sbjct: 226 MYFPYYGKKFHVNYTQPLVAVKFLNVTPNVEVNVECRINAANIATDDERDKFAGRVAFKL 285

Query: 300 EV 301
            +
Sbjct: 286 RI 287


>gi|215490093 ATPase, (Na+)/K+ transporting, beta 4 polypeptide
           isoform A [Homo sapiens]
          Length = 357

 Score =  181 bits (459), Expect = 7e-46
 Identities = 106/313 (33%), Positives = 167/313 (53%), Gaps = 41/313 (13%)

Query: 5   KAKEEGS--------WKK------FIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIF 50
           K +EEG         W+K      ++W+ E++ FL RTG SW  ILL Y  FY  LA + 
Sbjct: 68  KEEEEGQGQPTGNAWWQKLQIMSEYLWDPERRMFLARTGQSWSLILLIYFFFYASLAAVI 127

Query: 51  IGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLE 110
              +  + LTIS + PT+ +RV PPG+   P       +F  ++P +++ YV+++  FL+
Sbjct: 128 TLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQ 187

Query: 111 KYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYK 170
            Y DS Q +  +     D P       D N +  ++K C+FK  +L NCSGL D T+GY 
Sbjct: 188 GYNDSLQEEMNV-----DCPPGQYFIQDGNEDE-DKKACQFKRSFLKNCSGLEDPTFGYS 241

Query: 171 EGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYF 230
            G+PCI++K+NR++GF+P+                 + + V C  +R ++ D + ++ Y+
Sbjct: 242 TGQPCILLKMNRIVGFRPE---------------LGDPVKVSCKVQRGDEND-IRSISYY 285

Query: 231 GLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGEN-IGYSEKD 289
               S  F L+YYPYYGKL    Y  PL+A+ FT++  +  + ++C+  G+  I     D
Sbjct: 286 --PESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVIND 343

Query: 290 RFQGR--FDVKIE 300
           RF GR  F + IE
Sbjct: 344 RFVGRVIFTLNIE 356


>gi|4502281 Na+/K+ -ATPase beta 3 subunit [Homo sapiens]
          Length = 279

 Score =  174 bits (440), Expect = 1e-43
 Identities = 107/298 (35%), Positives = 160/298 (53%), Gaps = 40/298 (13%)

Query: 12  WKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDR 71
           WK FI+N    EFLGRT  SW  ILLFY++FYG LA +F  T+ VML T+++  P Y+D+
Sbjct: 16  WKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWVMLQTLNDEVPKYRDQ 75

Query: 72  VAPPGLTQIPQ-IQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVP 130
           +  PGL   P+ +   E +F  +DP SY  Y+ ++ +FL+ Y    Q++  +  D     
Sbjct: 76  IPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLEEQKNLTVCPD----- 130

Query: 131 SEPKERGDFNHERGERKV-CRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPK 189
                 G    ++G   V C+F +  L  CSG+ND  +GY +G PCI++K+NR++G KP+
Sbjct: 131 ------GALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIGLKPE 184

Query: 190 PPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKL 249
                             V  + C  K +ED   V    + G+       L+Y+PYYGK 
Sbjct: 185 -----------------GVPRIDCVSK-NEDIPNVAVYPHNGM-----IDLKYFPYYGKK 221

Query: 250 LQPKYLQPLLAVQFTNLTMDT--EIRIECKAYGE-NI-GYSEKDRFQGRFDVKIEVKS 303
           L   YLQPL+AVQ +    +T  E+ +ECK  G  N+    ++D+F GR   KI  ++
Sbjct: 222 LHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA 279


>gi|6912256 ATPase, (Na+)/K+ transporting, beta 4 polypeptide
           isoform B [Homo sapiens]
          Length = 353

 Score =  171 bits (433), Expect = 7e-43
 Identities = 104/313 (33%), Positives = 165/313 (52%), Gaps = 45/313 (14%)

Query: 5   KAKEEGS--------WKK------FIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIF 50
           K +EEG         W+K      ++W+ E++ FL RTG     ILL Y  FY  LA + 
Sbjct: 68  KEEEEGQGQPTGNAWWQKLQIMSEYLWDPERRMFLARTG----LILLIYFFFYASLAAVI 123

Query: 51  IGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLE 110
              +  + LTIS + PT+ +RV PPG+   P       +F  ++P +++ YV+++  FL+
Sbjct: 124 TLCMYTLFLTISPYIPTFTERVKPPGVMIRPFAHSLNFNFNVSEPDTWQHYVISLNGFLQ 183

Query: 111 KYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYK 170
            Y DS Q +  +     D P       D N +  ++K C+FK  +L NCSGL D T+GY 
Sbjct: 184 GYNDSLQEEMNV-----DCPPGQYFIQDGNEDE-DKKACQFKRSFLKNCSGLEDPTFGYS 237

Query: 171 EGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYF 230
            G+PCI++K+NR++GF+P+                 + + V C  +R ++ D + ++ Y+
Sbjct: 238 TGQPCILLKMNRIVGFRPE---------------LGDPVKVSCKVQRGDEND-IRSISYY 281

Query: 231 GLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGEN-IGYSEKD 289
               S  F L+YYPYYGKL    Y  PL+A+ FT++  +  + ++C+  G+  I     D
Sbjct: 282 --PESASFDLRYYPYYGKLTHVNYTSPLVAMHFTDVVKNQAVPVQCQLKGKGVINDVIND 339

Query: 290 RFQGR--FDVKIE 300
           RF GR  F + IE
Sbjct: 340 RFVGRVIFTLNIE 352


>gi|4557339 hydrogen/potassium-exchanging ATPase 4B [Homo sapiens]
          Length = 291

 Score =  150 bits (378), Expect = 2e-36
 Identities = 90/304 (29%), Positives = 154/304 (50%), Gaps = 29/304 (9%)

Query: 4   GKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISE 63
           G+  EE  ++++ WN +  + LGRT   W  I L+YV FY  + G+F   + V++ T+  
Sbjct: 11  GQRMEE--FQRYCWNPDTGQMLGRTLSRWVWISLYYVAFYVVMTGLFALCLYVLMQTVDP 68

Query: 64  FKPTYQDRVAPPGLTQIPQI---QKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDD 120
           + P YQD++  PG+T  P +   +  EI +  +D +++      +  FL  Y  +AQ D 
Sbjct: 69  YTPDYQDQLRSPGVTLRPDVYGEKGLEIVYNVSDNRTWADLTQTLHAFLAGYSPAAQEDS 128

Query: 121 MIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKL 180
           +   +C       +E   F      +  C+F  + L NCSGL D  +G++EGKPC IIK+
Sbjct: 129 I---NCTSEQYFFQE--SFRAPNHTKFSCKFTADMLQNCSGLADPNFGFEEGKPCFIIKM 183

Query: 181 NRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTG-KRDEDKDKVGNVEYFGLGNSPGFP 239
           NR++ F P                N +   V C    +  +  +   V+Y+    +  F 
Sbjct: 184 NRIVKFLPS---------------NGSAPRVDCAFLDQPRELGQPLQVKYYPPNGT--FS 226

Query: 240 LQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSE-KDRFQGRFDVK 298
           L Y+PYYGK  QP Y  PL+A +  N+  + E+ I CK   E++ ++   D ++G+ + K
Sbjct: 227 LHYFPYYGKKAQPHYSNPLVAAKLLNIPRNAEVAIVCKVMAEHVTFNNPHDPYEGKVEFK 286

Query: 299 IEVK 302
           ++++
Sbjct: 287 LKIE 290


>gi|20149698 l(3)mbt-like 2 [Homo sapiens]
          Length = 705

 Score = 30.8 bits (68), Expect = 1.5
 Identities = 17/43 (39%), Positives = 20/43 (46%), Gaps = 2/43 (4%)

Query: 84  QKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDC 126
           QK +I   P  PK YEA   N   +LEK K  A    +   DC
Sbjct: 491 QKNDIELTP--PKGYEAQTFNWENYLEKTKSKAAPSRLFNMDC 531


>gi|148612863 transient receptor potential cation channel, subfamily
            M, member 7 [Homo sapiens]
          Length = 1865

 Score = 30.8 bits (68), Expect = 1.5
 Identities = 13/46 (28%), Positives = 26/46 (56%)

Query: 164  DETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVL 209
            D  Y Y   +   +++L++ + F P PP+ E +  Y + + +PN+L
Sbjct: 1550 DTNYYYSAVERNNLMRLSQSIPFTPVPPRGEPVTVYRLEESSPNIL 1595


>gi|14249528 solute carrier family 35, member B4 [Homo sapiens]
          Length = 331

 Score = 28.5 bits (62), Expect = 7.7
 Identities = 11/31 (35%), Positives = 19/31 (61%)

Query: 32  WFKILLFYVIFYGCLAGIFIGTIQVMLLTIS 62
           WF +L+  +  Y C+ G+FI T +   LT++
Sbjct: 240 WFYLLMNIITQYVCIRGVFILTTECASLTVT 270


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.141    0.436 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,036,270
Number of Sequences: 37866
Number of extensions: 610403
Number of successful extensions: 1126
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 1
Number of HSP's that attempted gapping in prelim test: 1103
Number of HSP's gapped (non-prelim): 10
length of query: 303
length of database: 18,247,518
effective HSP length: 102
effective length of query: 201
effective length of database: 14,385,186
effective search space: 2891422386
effective search space used: 2891422386
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.