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Search of human proteins with 44680141
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
(571 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 1174 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 446 e-125
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 420 e-117
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 420 e-117
gi|38194229 kelch-like 17 [Homo sapiens] 419 e-117
gi|14780904 kelch-like 1 protein [Homo sapiens] 416 e-116
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 405 e-113
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 404 e-112
gi|55925604 kelch-like 18 [Homo sapiens] 391 e-109
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 391 e-108
gi|166235129 kelch-like 3 [Homo sapiens] 387 e-107
gi|11056006 kelch-like 12 [Homo sapiens] 384 e-106
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 380 e-105
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 380 e-105
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 353 3e-97
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 353 3e-97
gi|34101268 kelch-like 8 [Homo sapiens] 352 5e-97
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 332 7e-91
gi|148664209 kelch-like 10 [Homo sapiens] 313 3e-85
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 303 2e-82
gi|223890235 intracisternal A particle-promoted polypeptide isof... 282 7e-76
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 275 6e-74
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 271 1e-72
gi|24308181 kelch-like 9 [Homo sapiens] 269 4e-72
gi|45643138 kelch-like 13 [Homo sapiens] 266 4e-71
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 266 5e-71
gi|40018614 DRE1 protein [Homo sapiens] 263 4e-70
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 248 1e-65
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 247 2e-65
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 247 2e-65
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 1174 bits (3036), Expect = 0.0
Identities = 571/571 (100%), Positives = 571/571 (100%)
Query: 1 MDHTSPTYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYF 60
MDHTSPTYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYF
Sbjct: 1 MDHTSPTYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYF 60
Query: 61 KAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLV 120
KAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLV
Sbjct: 61 KAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLV 120
Query: 121 LKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHAD 180
LKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHAD
Sbjct: 121 LKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHAD 180
Query: 181 LDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEA 240
LDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEA
Sbjct: 181 LDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEA 240
Query: 241 NHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDS 300
NHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDS
Sbjct: 241 NHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDS 300
Query: 301 VEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWN 360
VEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWN
Sbjct: 301 VEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWN 360
Query: 361 PDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMT 420
PDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMT
Sbjct: 361 PDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMT 420
Query: 421 TTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGF 480
TTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGF
Sbjct: 421 TTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGF 480
Query: 481 IFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYL 540
IFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYL
Sbjct: 481 IFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYL 540
Query: 541 NTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
NTVQKYDPISDTWLDSAGMIYCRCNFGLTAL
Sbjct: 541 NTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 446 bits (1148), Expect = e-125
Identities = 243/561 (43%), Positives = 346/561 (61%), Gaps = 23/561 (4%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H Q L+ +NLLR+H ELCD++L VG KI+AH+V+L++ SPYF+AMFTG L+E +EV
Sbjct: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
+ IDE A++ ++++AYT + + + V++LLPAA LLQ+ + + CC FL+ QLDP N
Sbjct: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
C+GI FA+T+ CR+L A K+ NF+ V ++EEF L L +I+S+D LNV +EE
Sbjct: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
VF A+ +W+KY +QER+ L Q+L VRLPLLS KFL ++ LI+ D C+ L++E
Sbjct: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
Query: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-------VLCAVGGKSGLFACLDSVEMYFPQND 309
A Y +P+ R LM PR P+ VL AVGG A + SVE Y PQ +
Sbjct: 290 AKNYLLLPQER-----PLMQGPRTRPRKPIRCGEVLFAVGGWCSGDA-ISSVERYDPQTN 343
Query: 310 SWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTS- 368
W +A ++ R G+ VLD +Y +GG + + NSVE ++P TN W+S
Sbjct: 344 EWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGS--------SYLNSVERYDPKTNQWSSD 395
Query: 369 LERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAA 428
+ + R+++GV VL G LYA+GG DG S L VE+Y PK KW VA M+T R A
Sbjct: 396 VAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAV 455
Query: 429 AVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH 487
AVL G +YA+GG G + +N+VERY+P ++ W +A M +R H G V I+ VGG
Sbjct: 456 AVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR 515
Query: 488 NGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYD 547
+ + LSS ERY+P NQW+ M R+GVG AV++ L VGG G++YL T++ +D
Sbjct: 516 DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFD 575
Query: 548 PISDTWLDSAGMIYCRCNFGL 568
P ++TW GM Y R G+
Sbjct: 576 PDANTWRLYGGMNYRRLGGGV 596
Score = 36.2 bits (82), Expect = 0.083
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 7/62 (11%)
Query: 510 RPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLT 569
RP K R G L+ VGG +++V++YDP ++ W A M RC G++
Sbjct: 309 RPRKPIRCG-------EVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVS 361
Query: 570 AL 571
L
Sbjct: 362 VL 363
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 420 bits (1079), Expect = e-117
Identities = 222/553 (40%), Positives = 339/553 (61%), Gaps = 27/553 (4%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H+EQ + + +H +LCD+IL GD +I AH++VL+SVS YF AMFT ++ E E+
Sbjct: 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 215
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
+ + ++ +L ++++YAYTG + + +D +E LL A LLQ+ V++ CC FL QL P N
Sbjct: 216 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 275
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
C+GI FA+ GC DL+ A Y ++F V + +EF L +++ +++++D +N+ EE
Sbjct: 276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 335
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
T+ AL +W+++D+++R+K L++LL +RLPLL+ +FL + E N L RDD C+ L+ E
Sbjct: 336 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADM-ENNVLFRDDIECQKLIME 394
Query: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-----VLCAVGGKSGLFACLDSVEMYFPQNDSW 311
A+KYH +PE R ++ PR P+ L AVGG S+E Y + + W
Sbjct: 395 AMKYHLLPERR-----PMLQSPRTKPRKSTVGTLFAVGGMDSTKGA-TSIEKYDLRTNMW 448
Query: 312 IGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371
+A +N R +FG+ VLD K+YV+GG R G+ K N+VEC+NP T TW+ +
Sbjct: 449 TPVANMNGRRLQFGVAVLDDKLYVVGG-----RDGL---KTLNTVECYNPKTKTWSVMPP 500
Query: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431
M+ R LGV VL G +YA+GG+DG SYL +VE++ P+ R+W VA M+T RS AVL
Sbjct: 501 MSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 560
Query: 432 DGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNG- 489
G +YA+GG G + + SVE +DP + W + A M+ +R GV G ++ +GGH+
Sbjct: 561 SGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAP 620
Query: 490 VSHLSS-----IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544
S+L+S +ERYDP + WT M R VG ++ + LY VGG+ G +YLNTV+
Sbjct: 621 ASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVE 680
Query: 545 KYDPISDTWLDSA 557
YDP ++ W A
Sbjct: 681 AYDPQTNEWTQVA 693
Score = 142 bits (357), Expect = 1e-33
Identities = 75/185 (40%), Positives = 105/185 (56%), Gaps = 1/185 (0%)
Query: 386 GELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPA 444
G L+A+GG D S+EKY + W PVA M R F AVLD +Y +GG G
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 480
Query: 445 HMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQN 504
+N+VE Y+P +W ++ M+ R GV V+ G ++ VGGH+G S+L+++ER+DP
Sbjct: 481 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 540
Query: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRC 564
QW M PR+ VG AV+ LY VGG GSS L +V+ +DP ++ W A M R
Sbjct: 541 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 600
Query: 565 NFGLT 569
G+T
Sbjct: 601 GVGVT 605
Score = 110 bits (274), Expect = 5e-24
Identities = 55/140 (39%), Positives = 83/140 (59%), Gaps = 1/140 (0%)
Query: 433 GMIYAIGGYGPAH-MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS 491
G ++A+GG S+E+YD + W VA+M +R+ FGV V+ ++VVGG +G+
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 480
Query: 492 HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISD 551
L+++E Y+P W+V PM R G+G AV++ +Y VGGH G SYLNTV+++DP +
Sbjct: 481 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 540
Query: 552 TWLDSAGMIYCRCNFGLTAL 571
W A M R G+ L
Sbjct: 541 QWNFVATMSTPRSTVGVAVL 560
Score = 95.9 bits (237), Expect = 9e-20
Identities = 60/170 (35%), Positives = 93/170 (54%), Gaps = 15/170 (8%)
Query: 264 PEHRLSHQTVLMTRPRCAPKV------LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPL 317
P+ R + M+ PR V L AVGG+ G +CL SVE + P + W A +
Sbjct: 537 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLCAQM 595
Query: 318 NIPRYEFGICVLDQKVYVIGGI---ATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNE 374
+ R G+ + +Y IGG A+N+ ++ + VE ++P T+ WT++ M+
Sbjct: 596 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLS-----DCVERYDPKTDMWTAVASMSI 650
Query: 375 SRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRS 424
SR +GV +L +LYA+GGYDGQ+YL +VE Y P+ +W VAP+ R+
Sbjct: 651 SRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRA 700
Score = 70.1 bits (170), Expect = 5e-12
Identities = 38/94 (40%), Positives = 49/94 (52%)
Query: 478 LGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS 537
+G +F VGG + +SIE+YD N WT M R G AV+D+ LYVVGG G
Sbjct: 420 VGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 479
Query: 538 SYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
LNTV+ Y+P + TW M R G+ L
Sbjct: 480 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVL 513
Score = 55.5 bits (132), Expect = 1e-07
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 13/106 (12%)
Query: 284 VLCAVGGKSGLFACL-----DSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGG 338
+L A+GG + L D VE Y P+ D W +A ++I R G+C+L K+Y +GG
Sbjct: 610 LLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG 669
Query: 339 IATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVL 384
+ N+VE ++P TN WT + + R+ VV +
Sbjct: 670 YDGQA--------YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 707
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 420 bits (1079), Expect = e-117
Identities = 222/553 (40%), Positives = 339/553 (61%), Gaps = 27/553 (4%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H+EQ + + +H +LCD+IL GD +I AH++VL+SVS YF AMFT ++ E E+
Sbjct: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
+ + ++ +L ++++YAYTG + + +D +E LL A LLQ+ V++ CC FL QL P N
Sbjct: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
C+GI FA+ GC DL+ A Y ++F V + +EF L +++ +++++D +N+ EE
Sbjct: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
T+ AL +W+++D+++R+K L++LL +RLPLL+ +FL + E N L RDD C+ L+ E
Sbjct: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADM-ENNVLFRDDIECQKLIME 440
Query: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-----VLCAVGGKSGLFACLDSVEMYFPQNDSW 311
A+KYH +PE R ++ PR P+ L AVGG S+E Y + + W
Sbjct: 441 AMKYHLLPERR-----PMLQSPRTKPRKSTVGTLFAVGGMDSTKGA-TSIEKYDLRTNMW 494
Query: 312 IGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371
+A +N R +FG+ VLD K+YV+GG R G+ K N+VEC+NP T TW+ +
Sbjct: 495 TPVANMNGRRLQFGVAVLDDKLYVVGG-----RDGL---KTLNTVECYNPKTKTWSVMPP 546
Query: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431
M+ R LGV VL G +YA+GG+DG SYL +VE++ P+ R+W VA M+T RS AVL
Sbjct: 547 MSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 606
Query: 432 DGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNG- 489
G +YA+GG G + + SVE +DP + W + A M+ +R GV G ++ +GGH+
Sbjct: 607 SGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAP 666
Query: 490 VSHLSS-----IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544
S+L+S +ERYDP + WT M R VG ++ + LY VGG+ G +YLNTV+
Sbjct: 667 ASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVE 726
Query: 545 KYDPISDTWLDSA 557
YDP ++ W A
Sbjct: 727 AYDPQTNEWTQVA 739
Score = 142 bits (357), Expect = 1e-33
Identities = 75/185 (40%), Positives = 105/185 (56%), Gaps = 1/185 (0%)
Query: 386 GELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPA 444
G L+A+GG D S+EKY + W PVA M R F AVLD +Y +GG G
Sbjct: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 526
Query: 445 HMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQN 504
+N+VE Y+P +W ++ M+ R GV V+ G ++ VGGH+G S+L+++ER+DP
Sbjct: 527 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 586
Query: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRC 564
QW M PR+ VG AV+ LY VGG GSS L +V+ +DP ++ W A M R
Sbjct: 587 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 646
Query: 565 NFGLT 569
G+T
Sbjct: 647 GVGVT 651
Score = 110 bits (274), Expect = 5e-24
Identities = 55/140 (39%), Positives = 83/140 (59%), Gaps = 1/140 (0%)
Query: 433 GMIYAIGGYGPAH-MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS 491
G ++A+GG S+E+YD + W VA+M +R+ FGV V+ ++VVGG +G+
Sbjct: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 526
Query: 492 HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISD 551
L+++E Y+P W+V PM R G+G AV++ +Y VGGH G SYLNTV+++DP +
Sbjct: 527 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 586
Query: 552 TWLDSAGMIYCRCNFGLTAL 571
W A M R G+ L
Sbjct: 587 QWNFVATMSTPRSTVGVAVL 606
Score = 95.9 bits (237), Expect = 9e-20
Identities = 60/170 (35%), Positives = 93/170 (54%), Gaps = 15/170 (8%)
Query: 264 PEHRLSHQTVLMTRPRCAPKV------LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPL 317
P+ R + M+ PR V L AVGG+ G +CL SVE + P + W A +
Sbjct: 583 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLCAQM 641
Query: 318 NIPRYEFGICVLDQKVYVIGGI---ATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNE 374
+ R G+ + +Y IGG A+N+ ++ + VE ++P T+ WT++ M+
Sbjct: 642 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLS-----DCVERYDPKTDMWTAVASMSI 696
Query: 375 SRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRS 424
SR +GV +L +LYA+GGYDGQ+YL +VE Y P+ +W VAP+ R+
Sbjct: 697 SRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRA 746
Score = 70.1 bits (170), Expect = 5e-12
Identities = 38/94 (40%), Positives = 49/94 (52%)
Query: 478 LGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS 537
+G +F VGG + +SIE+YD N WT M R G AV+D+ LYVVGG G
Sbjct: 466 VGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 525
Query: 538 SYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
LNTV+ Y+P + TW M R G+ L
Sbjct: 526 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVL 559
Score = 55.5 bits (132), Expect = 1e-07
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 13/106 (12%)
Query: 284 VLCAVGGKSGLFACL-----DSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGG 338
+L A+GG + L D VE Y P+ D W +A ++I R G+C+L K+Y +GG
Sbjct: 656 LLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG 715
Query: 339 IATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVL 384
+ N+VE ++P TN WT + + R+ VV +
Sbjct: 716 YDGQA--------YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 753
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 419 bits (1076), Expect = e-117
Identities = 235/567 (41%), Positives = 327/567 (57%), Gaps = 12/567 (2%)
Query: 8 YMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGN 67
+ +A+ + H ++ +RQ LCDI+L V +I AHKVVLAS SPYF AMFT
Sbjct: 65 HSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNE 124
Query: 68 LSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAF 127
+SE + V ID AL +V++AYT + + + V++LLPAA+LLQ+ V CC F
Sbjct: 125 MSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKF 184
Query: 128 LESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSN 187
L SQLDP NC+GI FA+ + C DL AA +Y+ Q+F V +TEEF L + E+VS+
Sbjct: 185 LLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSS 244
Query: 188 DCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDD 247
D LNV +EE V+ A+ SW+K+DV R++++ +L+ VRLPLLS FL +A L+R
Sbjct: 245 DSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHH 304
Query: 248 RTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRC--APKVLCAVGGKSGLFACLDSVEMYF 305
CK LL EALK+H +PE R T RC A VL AVGG S LFA E Y
Sbjct: 305 PDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGS-LFAIHGDCEAYD 363
Query: 306 PQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNT 365
+ D W +A ++ R G+ + ++Y +GG +VE ++P TNT
Sbjct: 364 TRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGT--------SDLATVESYDPVTNT 415
Query: 366 WTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSC 425
W M RS LGV L G LY+ GGYDG S L S E+Y P W VA M+T R
Sbjct: 416 WQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRY 475
Query: 426 FAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVV 484
A LDG +YA+GGY +H+ +VE+Y+P + W VASM +R GV V+ G ++V
Sbjct: 476 VRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVA 535
Query: 485 GGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544
GG++G S L+S+ERY P W PM R+ +D +LY VGG+ GSS LN+++
Sbjct: 536 GGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIE 595
Query: 545 KYDPISDTWLDSAGMIYCRCNFGLTAL 571
KY+P ++ W+ ++ M R + G+ L
Sbjct: 596 KYNPRTNKWVAASCMFTRRSSVGVAVL 622
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 416 bits (1069), Expect = e-116
Identities = 226/555 (40%), Positives = 333/555 (60%), Gaps = 27/555 (4%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H+EQ + + + +LCD+IL VG+ KI AH++VL+SVS YF AMFT ++ E + E+
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
+ + ID AL +V++AYTG + + +DT+E+LL AA LLQ+ V++ CC FL L P N
Sbjct: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
C+GI FA+ GC +L A Y +N V + +EF L +L +++++D +NV EE
Sbjct: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
T+F+AL W+KYD+Q R L+ LL +RLPLL + L L E + L ++D C+ L+ E
Sbjct: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADL-ENHALFKNDLECQKLILE 432
Query: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-----VLCAVGGKSGLFACLDSVEMYFPQNDSW 311
A+KYH +PE R LM PR P+ L AVGG ++E Y + + W
Sbjct: 433 AMKYHLLPERR-----TLMQSPRTKPRKSTVGTLYAVGGMDNNKGA-TTIEKYDLRTNLW 486
Query: 312 IGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371
I +N R +FG+ V+D K++VIGG R G+ K N+VEC+NP T TWT L
Sbjct: 487 IQAGMMNGRRLQFGVAVIDDKLFVIGG-----RDGL---KTLNTVECYNPKTKTWTVLPP 538
Query: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431
M+ R LGV VL G +YA+GG+DG SYL +VE++ P+ ++W VA M+ RS A L
Sbjct: 539 MSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAAL 598
Query: 432 DGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
+G +Y++GG G + ++S+E YDP + W M A M +R GV GF++ VGGH+
Sbjct: 599 NGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAP 658
Query: 491 SH------LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544
+ L +ERYDP + WT+ P+ PR VG ++ + LY VGG+ G +YLNT++
Sbjct: 659 ASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTME 718
Query: 545 KYDPISDTWLDSAGM 559
YDP ++ W A +
Sbjct: 719 SYDPQTNEWTQMASL 733
Score = 131 bits (329), Expect = 2e-30
Identities = 75/209 (35%), Positives = 110/209 (52%), Gaps = 7/209 (3%)
Query: 361 PDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMT 420
P+ T R +ST+G LYA+GG D ++EKY + W M
Sbjct: 440 PERRTLMQSPRTKPRKSTVGT------LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMN 493
Query: 421 TTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLG 479
R F AV+D ++ IGG G +N+VE Y+P +W ++ M+ R GV V+ G
Sbjct: 494 GRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEG 553
Query: 480 FIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSY 539
I+ VGGH+G S+L+++ER+DP QWT M R+ VG A ++ LY VGG GSS
Sbjct: 554 PIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSC 613
Query: 540 LNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
L++++ YDP ++ W A M R G+
Sbjct: 614 LSSMEYYDPHTNKWNMCAPMCKRRGGVGV 642
Score = 112 bits (280), Expect = 9e-25
Identities = 55/140 (39%), Positives = 80/140 (57%), Gaps = 1/140 (0%)
Query: 433 GMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS 491
G +YA+GG ++E+YD + W M +R+ FGV V+ +FV+GG +G+
Sbjct: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
Query: 492 HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISD 551
L+++E Y+P WTV PM R G+G V++ +Y VGGH G SYLNTV+++DP S
Sbjct: 519 TLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQ 578
Query: 552 TWLDSAGMIYCRCNFGLTAL 571
W A M R G+ AL
Sbjct: 579 QWTFVASMSIARSTVGVAAL 598
Score = 89.0 bits (219), Expect = 1e-17
Identities = 49/147 (33%), Positives = 79/147 (53%), Gaps = 3/147 (2%)
Query: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
L +VGG+ G +CL S+E Y P + W AP+ R G+ D +Y +GG +
Sbjct: 602 LYSVGGRDGS-SCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGG--HDAP 658
Query: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404
+ + VE ++P T+TWT + ++ R +GV +L LYA+GGYDGQ+YL ++E
Sbjct: 659 ASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTME 718
Query: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVL 431
Y P+ +W +A + R+ V+
Sbjct: 719 SYDPQTNEWTQMASLNIGRAGACVVVI 745
Score = 64.3 bits (155), Expect = 3e-10
Identities = 35/94 (37%), Positives = 49/94 (52%)
Query: 478 LGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS 537
+G ++ VGG + ++IE+YD N W M R G AVID+ L+V+GG G
Sbjct: 458 VGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGL 517
Query: 538 SYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
LNTV+ Y+P + TW M R G+T L
Sbjct: 518 KTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVL 551
Score = 32.7 bits (73), Expect = 0.92
Identities = 29/86 (33%), Positives = 40/86 (46%), Gaps = 11/86 (12%)
Query: 250 CKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKV------LCAVGGKSGLFACLDSVEM 303
C LL+ +Y P+ ++ PR A V L AVGG G L+++E
Sbjct: 663 CSRLLDYVERYD--PKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQ-TYLNTMES 719
Query: 304 YFPQNDSWIGLAPLNIPRYEFGICVL 329
Y PQ + W +A LNI R G CV+
Sbjct: 720 YDPQTNEWTQMASLNIGR--AGACVV 743
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 405 bits (1041), Expect = e-113
Identities = 222/552 (40%), Positives = 327/552 (59%), Gaps = 27/552 (4%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H+EQ L+ + + +LCD++L G ++I AH++VL++VS YF AMFT ++ E + EV
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
+ +D AL ++V+YAYTG + + +DT+ESLL AA LLQ+ V+ C FL QL P N
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
C+GI F + GC +L A KY ++F V + +EF L ++ +++ +D +NV EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
T+F+AL W+ +DVQ RQ L LL+ +RLPLL + L L E + + D C+ LL E
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADL-ETSSMFTGDLECQKLLME 402
Query: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-----VLCAVGGKSGLFACLDSVEMYFPQNDSW 311
A+KYH +PE R +M PR P+ L AVGG + ++E Y + +SW
Sbjct: 403 AMKYHLLPERR-----SMMQSPRTKPRKSTVGALYAVGGMDAMKG-TTTIEKYDLRTNSW 456
Query: 312 IGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371
+ + +N R +FG+ V+D K+YV+GG R G+ K N+VEC+NP WT +
Sbjct: 457 LHIGTMNGRRLQFGVAVIDNKLYVVGG-----RDGL---KTLNTVECFNPVGKIWTVMPP 508
Query: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431
M+ R LGV L G +YA+GG+DG SYL +VE++ P+ R+W VA M+T RS L
Sbjct: 509 MSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
Query: 432 DGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH--- 487
+ +YAIGG G + + S+E +DP + W + A M+ +R GV GF++VVGGH
Sbjct: 569 NNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAP 628
Query: 488 --NGVSHLSS-IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544
N S LS +ERYDP + W+ P+ PR V + + LYVVGG+ G +YLNTV+
Sbjct: 629 ASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVE 688
Query: 545 KYDPISDTWLDS 556
YD + W +S
Sbjct: 689 SYDAQRNEWKES 700
Score = 128 bits (321), Expect = 2e-29
Identities = 69/209 (33%), Positives = 108/209 (51%), Gaps = 7/209 (3%)
Query: 361 PDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMT 420
P+ + R +ST+G LYA+GG D ++EKY + W + M
Sbjct: 410 PERRSMMQSPRTKPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMN 463
Query: 421 TTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLG 479
R F AV+D +Y +GG G +N+VE ++P W ++ M+ R GV + G
Sbjct: 464 GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEG 523
Query: 480 FIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSY 539
++ VGGH+G S+L+++ER+DP QW M PR+ VG ++N LY +GG GSS
Sbjct: 524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC 583
Query: 540 LNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
L +++ +DP ++ W A M R G+
Sbjct: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGV 612
Score = 108 bits (270), Expect = 1e-23
Identities = 64/183 (34%), Positives = 96/183 (52%), Gaps = 9/183 (4%)
Query: 392 GGYDGQSYLQSVEKY--IPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAH-MNS 448
G + Q L KY +P+ R +P T R G +YA+GG +
Sbjct: 392 GDLECQKLLMEAMKYHLLPERRSMMQ-SPRTKPRKSTV-----GALYAVGGMDAMKGTTT 445
Query: 449 VERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTV 508
+E+YD +SW + +M +R+ FGV V+ ++VVGG +G+ L+++E ++P WTV
Sbjct: 446 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV 505
Query: 509 CRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
PM R G+G A ++ +Y VGGH G SYLNTV+++DP W A M R G+
Sbjct: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
Query: 569 TAL 571
AL
Sbjct: 566 VAL 568
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 404 bits (1037), Expect = e-112
Identities = 221/549 (40%), Positives = 325/549 (59%), Gaps = 27/549 (4%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H+EQ L+ + + +LCD++L G ++I AH++VL++VS YF AMFT ++ E + EV
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
+ +D AL ++V+YAYTG + + +DT+ESLL AA LLQ+ V+ C FL QL P N
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
C+GI F + GC +L A KY ++F V + +EF L ++ +++ +D +NV EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
T+F+AL W+ +DVQ RQ L LL+ +RLPLL + L L E + + D C+ LL E
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADL-ETSSMFTGDLECQKLLME 402
Query: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-----VLCAVGGKSGLFACLDSVEMYFPQNDSW 311
A+KYH +PE R +M PR P+ L AVGG + ++E Y + +SW
Sbjct: 403 AMKYHLLPERR-----SMMQSPRTKPRKSTVGALYAVGGMDAMKG-TTTIEKYDLRTNSW 456
Query: 312 IGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371
+ + +N R +FG+ V+D K+YV+GG R G+ K N+VEC+NP WT +
Sbjct: 457 LHIGTMNGRRLQFGVAVIDNKLYVVGG-----RDGL---KTLNTVECFNPVGKIWTVMPP 508
Query: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431
M+ R LGV L G +YA+GG+DG SYL +VE++ P+ R+W VA M+T RS L
Sbjct: 509 MSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
Query: 432 DGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH--- 487
+ +YAIGG G + + S+E +DP + W + A M+ +R GV GF++VVGGH
Sbjct: 569 NNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAP 628
Query: 488 --NGVSHLSS-IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544
N S LS +ERYDP + W+ P+ PR V + + LYVVGG+ G +YLNTV+
Sbjct: 629 ASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVE 688
Query: 545 KYDPISDTW 553
YD + W
Sbjct: 689 SYDAQRNEW 697
Score = 128 bits (321), Expect = 2e-29
Identities = 69/209 (33%), Positives = 108/209 (51%), Gaps = 7/209 (3%)
Query: 361 PDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMT 420
P+ + R +ST+G LYA+GG D ++EKY + W + M
Sbjct: 410 PERRSMMQSPRTKPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMN 463
Query: 421 TTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLG 479
R F AV+D +Y +GG G +N+VE ++P W ++ M+ R GV + G
Sbjct: 464 GRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEG 523
Query: 480 FIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSY 539
++ VGGH+G S+L+++ER+DP QW M PR+ VG ++N LY +GG GSS
Sbjct: 524 PMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSC 583
Query: 540 LNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
L +++ +DP ++ W A M R G+
Sbjct: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGV 612
Score = 108 bits (270), Expect = 1e-23
Identities = 64/183 (34%), Positives = 96/183 (52%), Gaps = 9/183 (4%)
Query: 392 GGYDGQSYLQSVEKY--IPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAH-MNS 448
G + Q L KY +P+ R +P T R G +YA+GG +
Sbjct: 392 GDLECQKLLMEAMKYHLLPERRSMMQ-SPRTKPRKSTV-----GALYAVGGMDAMKGTTT 445
Query: 449 VERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTV 508
+E+YD +SW + +M +R+ FGV V+ ++VVGG +G+ L+++E ++P WTV
Sbjct: 446 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV 505
Query: 509 CRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
PM R G+G A ++ +Y VGGH G SYLNTV+++DP W A M R G+
Sbjct: 506 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV 565
Query: 569 TAL 571
AL
Sbjct: 566 VAL 568
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 391 bits (1005), Expect = e-109
Identities = 212/536 (39%), Positives = 307/536 (57%), Gaps = 13/536 (2%)
Query: 28 LRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETALQ 87
+R+ +LCD+ L++GD K AH++VLA+ PYF AMFT ++ E + E+ Q +D +AL+
Sbjct: 31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALE 90
Query: 88 AIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETY 147
A++ +AY G + I Q V+SLL A+ LQ++ + CC FL +L P NC+G+ +FAET
Sbjct: 91 ALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETM 150
Query: 148 GCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIK 207
C LY AA +I Q+F V +EEF L D+ E+VS D LNV +EE VF A +W++
Sbjct: 151 MCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVR 210
Query: 208 YDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHR 267
YD ++R YL +LL+++RLPL +FL+ + + L+R C+ L++EA YH MPE R
Sbjct: 211 YDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMPERR 270
Query: 268 LSHQTVLMTRPRCAPKV---LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEF 324
H TRPRC + + AVGG + L+ VE++ P + W P+ R
Sbjct: 271 -PHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRV 329
Query: 325 GICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVL 384
G+ V++ +Y IGG +R ++VE +NP+T+TWT + MN RS +G VVL
Sbjct: 330 GVAVVNGLLYAIGGYDGQLR--------LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
Query: 385 AGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GP 443
G++Y GGYDG S L SVE Y P+ KW V M++ RS V +G IY GG+ G
Sbjct: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL 441
Query: 444 AHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQ 503
+SVE Y+ +W A M +KR G + +FV GG++G LS E Y
Sbjct: 442 QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVA 501
Query: 504 NQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM 559
+QW + PM R+ V LY VGG+ G S L++V+ YDP +D W A M
Sbjct: 502 DQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPM 557
Score = 147 bits (370), Expect = 3e-35
Identities = 77/190 (40%), Positives = 110/190 (57%), Gaps = 2/190 (1%)
Query: 384 LAGELYALGGYDGQS-YLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY- 441
+AG +YA+GG + L VE + P W+ PMTT RS AV++G++YAIGGY
Sbjct: 286 IAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYD 345
Query: 442 GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDP 501
G +++VE Y+P D+W V SM KR G V+ G I+V GG++G S LSS+E Y P
Sbjct: 346 GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSP 405
Query: 502 HQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIY 561
++WTV M R+ G V + +YV GGH G ++V+ Y+ + TW +AGM+
Sbjct: 406 ETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLN 465
Query: 562 CRCNFGLTAL 571
RC G +L
Sbjct: 466 KRCRHGAASL 475
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 391 bits (1004), Expect = e-108
Identities = 208/520 (40%), Positives = 318/520 (61%), Gaps = 27/520 (5%)
Query: 50 KVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLL 109
++VL+SVS YF AMFT ++ E E++ + ++ +L ++++YAYTG + + +D +E LL
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 110 PAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQ 169
A LLQ+ V++ CC FL QL P NC+GI FA+ GC DL+ A Y ++F V +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 170 TEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLL 229
+EF L +++ +++++D +N+ EET+ AL +W+++D+++R+K L++LL +RLPLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 230 SVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPK-----V 284
+ +FL + E N L RDD C+ L+ EA+KYH +PE R ++ PR P+
Sbjct: 354 APQFLADM-ENNVLFRDDIECQKLIMEAMKYHLLPERR-----PMLQSPRTKPRKSTVGT 407
Query: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
L AVGG S+E Y + + W +A +N R +FG+ VLD K+YV+GG R
Sbjct: 408 LFAVGGMDSTKGA-TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-----R 461
Query: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404
G+ K N+VEC+NP T TW+ + M+ R LGV VL G +YA+GG+DG SYL +VE
Sbjct: 462 DGL---KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVE 518
Query: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVA 463
++ P+ R+W VA M+T RS AVL G +YA+GG G + + SVE +DP + W + A
Sbjct: 519 RWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCA 578
Query: 464 SMADKRIHFGVGVMLGFIFVVGGHNG-VSHLSS-----IERYDPHQNQWTVCRPMKEPRT 517
M+ +R GV G ++ +GGH+ S+L+S +ERYDP + WT M R
Sbjct: 579 QMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRD 638
Query: 518 GVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSA 557
VG ++ + LY VGG+ G +YLNTV+ YDP ++ W A
Sbjct: 639 AVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVA 678
Score = 142 bits (357), Expect = 1e-33
Identities = 75/185 (40%), Positives = 105/185 (56%), Gaps = 1/185 (0%)
Query: 386 GELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPA 444
G L+A+GG D S+EKY + W PVA M R F AVLD +Y +GG G
Sbjct: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 465
Query: 445 HMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQN 504
+N+VE Y+P +W ++ M+ R GV V+ G ++ VGGH+G S+L+++ER+DP
Sbjct: 466 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 525
Query: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRC 564
QW M PR+ VG AV+ LY VGG GSS L +V+ +DP ++ W A M R
Sbjct: 526 QWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRG 585
Query: 565 NFGLT 569
G+T
Sbjct: 586 GVGVT 590
Score = 110 bits (274), Expect = 5e-24
Identities = 55/140 (39%), Positives = 83/140 (59%), Gaps = 1/140 (0%)
Query: 433 GMIYAIGGYGPAH-MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS 491
G ++A+GG S+E+YD + W VA+M +R+ FGV V+ ++VVGG +G+
Sbjct: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 465
Query: 492 HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISD 551
L+++E Y+P W+V PM R G+G AV++ +Y VGGH G SYLNTV+++DP +
Sbjct: 466 TLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQAR 525
Query: 552 TWLDSAGMIYCRCNFGLTAL 571
W A M R G+ L
Sbjct: 526 QWNFVATMSTPRSTVGVAVL 545
Score = 95.9 bits (237), Expect = 9e-20
Identities = 60/170 (35%), Positives = 93/170 (54%), Gaps = 15/170 (8%)
Query: 264 PEHRLSHQTVLMTRPRCAPKV------LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPL 317
P+ R + M+ PR V L AVGG+ G +CL SVE + P + W A +
Sbjct: 522 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS-SCLKSVECFDPHTNKWTLCAQM 580
Query: 318 NIPRYEFGICVLDQKVYVIGGI---ATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNE 374
+ R G+ + +Y IGG A+N+ ++ + VE ++P T+ WT++ M+
Sbjct: 581 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLS-----DCVERYDPKTDMWTAVASMSI 635
Query: 375 SRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRS 424
SR +GV +L +LYA+GGYDGQ+YL +VE Y P+ +W VAP+ R+
Sbjct: 636 SRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRA 685
Score = 70.1 bits (170), Expect = 5e-12
Identities = 38/94 (40%), Positives = 49/94 (52%)
Query: 478 LGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS 537
+G +F VGG + +SIE+YD N WT M R G AV+D+ LYVVGG G
Sbjct: 405 VGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGL 464
Query: 538 SYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
LNTV+ Y+P + TW M R G+ L
Sbjct: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVL 498
Score = 55.5 bits (132), Expect = 1e-07
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 13/106 (12%)
Query: 284 VLCAVGGKSGLFACL-----DSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGG 338
+L A+GG + L D VE Y P+ D W +A ++I R G+C+L K+Y +GG
Sbjct: 595 LLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG 654
Query: 339 IATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVL 384
+ N+VE ++P TN WT + + R+ VV +
Sbjct: 655 YDGQA--------YLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 692
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 387 bits (995), Expect = e-107
Identities = 214/547 (39%), Positives = 317/547 (57%), Gaps = 24/547 (4%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H + + +N LR LCD+++ DV+I AH+VVLA+ SPYF AMFTG++SE + ++
Sbjct: 32 HMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKI 91
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
E + +D L +++Y YT + ++++ V+ LLPAA+LLQ+ V + CC FL+SQL P N
Sbjct: 92 EIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTN 151
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
C+GI FA+ + C DL A Y Q+F V EEF L+ + ++S+D L V++EE
Sbjct: 152 CLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEE 211
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
VF A+ SWI Y+ + R +++A+L+ VRLPLL +L + E LI+++ TCK L E
Sbjct: 212 KVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIE 271
Query: 257 ALKYHFMPEHRLSHQTVLMTRPR-------CAPKVLCAVGGKSGLFACLDSVEMYFPQND 309
A+KYH +P Q +L+ PR PKV+ VGG++ + SVE Y + D
Sbjct: 272 AMKYHLLP----LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAP--KAIRSVECYDFEED 325
Query: 310 SWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSL 369
W +A L R G+ + VY +GG ++R +V+ ++ + WTS+
Sbjct: 326 RWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR--------VRTVDVYDGVKDQWTSI 377
Query: 370 ERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAA 429
M E RSTLG VL LYA+GG+DG + L SVE Y K +W VAPM T RS
Sbjct: 378 ASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVG 437
Query: 430 VLDGMIYAIGGYGPAH---MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGG 486
V++G +YA+GGY A +++VE+Y+P+ + W VA M+ +R GVGV+ G ++ GG
Sbjct: 438 VVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG 497
Query: 487 HNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKY 546
H+G S+E YDP N W M R G ++ LYVVGG GS L +V+ Y
Sbjct: 498 HDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYY 557
Query: 547 DPISDTW 553
+P++D W
Sbjct: 558 NPVTDKW 564
Score = 96.7 bits (239), Expect = 5e-20
Identities = 49/138 (35%), Positives = 79/138 (57%)
Query: 431 LDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
L ++ +GG P + SVE YD +D W+ +A + +R GV M G ++ VGG NG
Sbjct: 299 LPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGS 358
Query: 491 SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPIS 550
+ +++ YD ++QWT M+E R+ +GAAV+++ LY VGG GS+ L +V+ Y +
Sbjct: 359 LRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKT 418
Query: 551 DTWLDSAGMIYCRCNFGL 568
+ W A M R + G+
Sbjct: 419 NEWFFVAPMNTRRSSVGV 436
Score = 52.0 bits (123), Expect = 1e-06
Identities = 28/96 (29%), Positives = 42/96 (43%)
Query: 476 VMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHS 535
V L + +V G + S+E YD +++W + R G + ++Y VGG +
Sbjct: 297 VSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFN 356
Query: 536 GSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
GS + TV YD + D W A M R G L
Sbjct: 357 GSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVL 392
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 384 bits (986), Expect = e-106
Identities = 215/563 (38%), Positives = 314/563 (55%), Gaps = 12/563 (2%)
Query: 13 LTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKE 72
+T+ H++ +L +N LR+ + LCD+ LRV AH++VLA+ S YF AMFT LSEK
Sbjct: 11 MTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKG 70
Query: 73 NSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQL 132
V+ Q + + ++ ++++ YT TV ++ + V+ LLPAA LLQ+K V + CC FLESQL
Sbjct: 71 KPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQL 130
Query: 133 DPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNV 192
DP NC+GI FAET+ C DL AA + ++F V Q EEF L+ ++++++ D + V
Sbjct: 131 DPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQV 190
Query: 193 ATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKH 252
+EE VF A+ +W+K+ +ER++ L LL VR+PLL+ +++T + +A IR C+
Sbjct: 191 DSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRD 250
Query: 253 LLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWI 312
L++EA K+H PE R Q A +VL VGG + +D VE Y P+ W
Sbjct: 251 LVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWS 310
Query: 313 GLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWN---PDTNTWTSL 369
L + R L ++YVIGG R +SVEC + + W S+
Sbjct: 311 FLPSITRKRRYVASVSLHDRIYVIGGYDG--------RSRLSSVECLDYTADEDGVWYSV 362
Query: 370 ERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAA 429
MN R G L +Y GG+DG S+E+Y P I +W + M T R
Sbjct: 363 APMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLV 422
Query: 430 VLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN 488
V G+IY +GGY G +NSVE+YDP W V MA KR GV ++ I+VVGG +
Sbjct: 423 VASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD 482
Query: 489 GVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDP 548
G +HLSS+E Y+ + WT M PR VGA V+ LY + G+ G+S L++++ YDP
Sbjct: 483 GTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDP 542
Query: 549 ISDTWLDSAGMIYCRCNFGLTAL 571
I D+W M RC+ G+ L
Sbjct: 543 IIDSWEVVTSMGTQRCDAGVCVL 565
Score = 35.4 bits (80), Expect = 0.14
Identities = 23/64 (35%), Positives = 31/64 (48%), Gaps = 7/64 (10%)
Query: 275 MTRPRCAPKV------LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICV 328
MT PRC L A+ G G + L S+E Y P DSW + + R + G+CV
Sbjct: 506 MTTPRCYVGATVLRGRLYAIAGYDGN-SLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCV 564
Query: 329 LDQK 332
L +K
Sbjct: 565 LREK 568
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 380 bits (976), Expect = e-105
Identities = 207/543 (38%), Positives = 315/543 (58%), Gaps = 16/543 (2%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H ++ + +N LR + LCD+ + D++I AH+VVLA+ SPYF AMFTG +SE V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
+ +D L+ +++Y YT + ++++ V+ LLPAA LLQ++ V K CC FLESQL P N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
C+GI FA+ + C DL A Y Q+F V +EEF L + ++S+D L +++EE
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
VF A+ +W+ +D RQ+++A+L+ VRLPLL ++L + E L+++ CK L E
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 257 ALKYHFMP-EHRLSHQTV--LMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIG 313
A+KYH +P E R+ ++V + P PK++ VGG++ + SVE Y + + W
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAP--KAIRSVECYDFKEERWHQ 339
Query: 314 LAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMN 373
+A L R G+ + V+ +GG ++R +V+ ++P + WTS+ M
Sbjct: 340 VAELPSRRCRAGMVYMAGLVFAVGGFNGSLR--------VRTVDSYDPVKDQWTSVANMR 391
Query: 374 ESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDG 433
+ RSTLG VL G LYA+GG+DG + L SVE Y K +W VAPM T RS V+ G
Sbjct: 392 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 451
Query: 434 MIYAIGGYGPAH---MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
++YA+GGY A +++VE Y+ + + W +A M+ +R GVGV+ ++ VGGH+G
Sbjct: 452 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGP 511
Query: 491 SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPIS 550
S+E YDP N W M R G ++ LYVVGG GS L +V+ Y+P +
Sbjct: 512 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTT 571
Query: 551 DTW 553
D W
Sbjct: 572 DKW 574
Score = 101 bits (252), Expect = 2e-21
Identities = 50/138 (36%), Positives = 80/138 (57%)
Query: 431 LDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
L ++ +GG P + SVE YD ++ W VA + +R G+ M G +F VGG NG
Sbjct: 309 LPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 368
Query: 491 SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPIS 550
+ +++ YDP ++QWT M++ R+ +GAAV++ LY VGG GS+ L++V+ Y+ S
Sbjct: 369 LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKS 428
Query: 551 DTWLDSAGMIYCRCNFGL 568
+ W A M R + G+
Sbjct: 429 NEWFHVAPMNTRRSSVGV 446
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 380 bits (976), Expect = e-105
Identities = 207/543 (38%), Positives = 315/543 (58%), Gaps = 16/543 (2%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H ++ + +N LR + LCD+ + D++I AH+VVLA+ SPYF AMFTG +SE V
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
+ +D L+ +++Y YT + ++++ V+ LLPAA LLQ++ V K CC FLESQL P N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
C+GI FA+ + C DL A Y Q+F V +EEF L + ++S+D L +++EE
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
VF A+ +W+ +D RQ+++A+L+ VRLPLL ++L + E L+++ CK L E
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
Query: 257 ALKYHFMP-EHRLSHQTV--LMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIG 313
A+KYH +P E R+ ++V + P PK++ VGG++ + SVE Y + + W
Sbjct: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAP--KAIRSVECYDFKEERWHQ 335
Query: 314 LAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMN 373
+A L R G+ + V+ +GG ++R +V+ ++P + WTS+ M
Sbjct: 336 VAELPSRRCRAGMVYMAGLVFAVGGFNGSLR--------VRTVDSYDPVKDQWTSVANMR 387
Query: 374 ESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDG 433
+ RSTLG VL G LYA+GG+DG + L SVE Y K +W VAPM T RS V+ G
Sbjct: 388 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 447
Query: 434 MIYAIGGYGPAH---MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
++YA+GGY A +++VE Y+ + + W +A M+ +R GVGV+ ++ VGGH+G
Sbjct: 448 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGP 507
Query: 491 SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPIS 550
S+E YDP N W M R G ++ LYVVGG GS L +V+ Y+P +
Sbjct: 508 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTT 567
Query: 551 DTW 553
D W
Sbjct: 568 DKW 570
Score = 101 bits (252), Expect = 2e-21
Identities = 50/138 (36%), Positives = 80/138 (57%)
Query: 431 LDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
L ++ +GG P + SVE YD ++ W VA + +R G+ M G +F VGG NG
Sbjct: 305 LPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 364
Query: 491 SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPIS 550
+ +++ YDP ++QWT M++ R+ +GAAV++ LY VGG GS+ L++V+ Y+ S
Sbjct: 365 LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKS 424
Query: 551 DTWLDSAGMIYCRCNFGL 568
+ W A M R + G+
Sbjct: 425 NEWFHVAPMNTRRSSVGV 442
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 353 bits (905), Expect = 3e-97
Identities = 206/559 (36%), Positives = 308/559 (55%), Gaps = 18/559 (3%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVG-----DVKIHAHKVVLASVSPYFKAMFTGNLSEK 71
H++Q +N LR +LCD+ L+V + AHKVVLAS SP FKAMFT L E+
Sbjct: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
Query: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131
V + I ++ ++E+AYT ++ + + V ++ A + QI V++ C FL Q
Sbjct: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Query: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191
LDP N IGI+ FAE GC +L+ A +YI +F V + EEFF L+H L ++S D LN
Sbjct: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
Query: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
V E VF+A +W+KYD ++R+ Y+ LL +VR L+ FL + +++ D CK
Sbjct: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
Query: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLF-ACLDSVEMYFPQNDS 310
L + + E L T +M P APKV + G F L +E Y P + +
Sbjct: 299 DYLVKIFE-----ELTLHKPTQVM--PCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
Query: 311 WIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370
W+ LA L +PR CV+ +Y +GG N G T ++++C+NP TN W+
Sbjct: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGG-RNNSPDGNT---DSSALDCYNPMTNQWSPCA 407
Query: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
M+ R+ +GV V+ G +YA+GG G + SVE+Y P+ +W VAPM T R AV
Sbjct: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
Query: 431 LDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNG 489
L+ ++YA+GG+ G +NS E Y P ++ W M+ +M R GV V+ I+ GG++G
Sbjct: 468 LNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG 527
Query: 490 VSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPI 549
L+S+ERYD WT PMK R+ +G V +YV+GG+ G ++L++V+ YDP
Sbjct: 528 QDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPD 587
Query: 550 SDTWLDSAGMIYCRCNFGL 568
+DTW + M R G+
Sbjct: 588 TDTWSEVTRMTSGRSGVGV 606
Score = 134 bits (336), Expect = 3e-31
Identities = 80/195 (41%), Positives = 101/195 (51%), Gaps = 14/195 (7%)
Query: 287 AVGGKSGLFACL--DSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
AVGG G C+ +SVE Y P+ D W +AP+ R G+ VL++ +Y +GG R
Sbjct: 427 AVGGSHG---CIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR 483
Query: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404
NS EC+ P+ N W + MN RS GV VL +YA GGYDGQ L SVE
Sbjct: 484 L--------NSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVE 535
Query: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVA 463
+Y + W VAPM RS V G IY +GGY G ++SVE YDP D+W V
Sbjct: 536 RYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVT 595
Query: 464 SMADKRIHFGVGVML 478
M R GV V +
Sbjct: 596 RMTSGRSGVGVAVTM 610
Score = 122 bits (307), Expect = 7e-28
Identities = 68/189 (35%), Positives = 101/189 (53%), Gaps = 6/189 (3%)
Query: 388 LYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-----G 442
+Y GGY QS L +E Y P W +A + RS A V+ G++YA+GG G
Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 443 PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPH 502
++++ Y+P + W A M+ R GVGV+ G I+ VGG +G H +S+ERY+P
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 503 QNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYC 562
+++W + PM R GVG AV++ LY VGG G++ LN+ + Y P + W M
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI 506
Query: 563 RCNFGLTAL 571
R G+ L
Sbjct: 507 RSGAGVCVL 515
Score = 98.6 bits (244), Expect = 1e-20
Identities = 57/148 (38%), Positives = 77/148 (52%), Gaps = 9/148 (6%)
Query: 283 KVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATN 342
++L AVGG G L+S E Y+P+ + W + +N R G+CVL +Y GG
Sbjct: 470 RLLYAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG- 527
Query: 343 VRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQS 402
+ NSVE ++ +T TWT + M RS LG+ V G +Y LGGYDG ++L S
Sbjct: 528 -------QDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDS 580
Query: 403 VEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
VE Y P W V MT+ RS AV
Sbjct: 581 VECYDPDTDTWSEVTRMTSGRSGVGVAV 608
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 353 bits (905), Expect = 3e-97
Identities = 206/559 (36%), Positives = 308/559 (55%), Gaps = 18/559 (3%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVG-----DVKIHAHKVVLASVSPYFKAMFTGNLSEK 71
H++Q +N LR +LCD+ L+V + AHKVVLAS SP FKAMFT L E+
Sbjct: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
Query: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131
V + I ++ ++E+AYT ++ + + V ++ A + QI V++ C FL Q
Sbjct: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Query: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191
LDP N IGI+ FAE GC +L+ A +YI +F V + EEFF L+H L ++S D LN
Sbjct: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
Query: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
V E VF+A +W+KYD ++R+ Y+ LL +VR L+ FL + +++ D CK
Sbjct: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
Query: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLF-ACLDSVEMYFPQNDS 310
L + + E L T +M P APKV + G F L +E Y P + +
Sbjct: 299 DYLVKIFE-----ELTLHKPTQVM--PCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
Query: 311 WIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370
W+ LA L +PR CV+ +Y +GG N G T ++++C+NP TN W+
Sbjct: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGG-RNNSPDGNT---DSSALDCYNPMTNQWSPCA 407
Query: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
M+ R+ +GV V+ G +YA+GG G + SVE+Y P+ +W VAPM T R AV
Sbjct: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
Query: 431 LDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNG 489
L+ ++YA+GG+ G +NS E Y P ++ W M+ +M R GV V+ I+ GG++G
Sbjct: 468 LNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG 527
Query: 490 VSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPI 549
L+S+ERYD WT PMK R+ +G V +YV+GG+ G ++L++V+ YDP
Sbjct: 528 QDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPD 587
Query: 550 SDTWLDSAGMIYCRCNFGL 568
+DTW + M R G+
Sbjct: 588 TDTWSEVTRMTSGRSGVGV 606
Score = 134 bits (336), Expect = 3e-31
Identities = 80/195 (41%), Positives = 101/195 (51%), Gaps = 14/195 (7%)
Query: 287 AVGGKSGLFACL--DSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
AVGG G C+ +SVE Y P+ D W +AP+ R G+ VL++ +Y +GG R
Sbjct: 427 AVGGSHG---CIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR 483
Query: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404
NS EC+ P+ N W + MN RS GV VL +YA GGYDGQ L SVE
Sbjct: 484 L--------NSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVE 535
Query: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVA 463
+Y + W VAPM RS V G IY +GGY G ++SVE YDP D+W V
Sbjct: 536 RYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVT 595
Query: 464 SMADKRIHFGVGVML 478
M R GV V +
Sbjct: 596 RMTSGRSGVGVAVTM 610
Score = 122 bits (307), Expect = 7e-28
Identities = 68/189 (35%), Positives = 101/189 (53%), Gaps = 6/189 (3%)
Query: 388 LYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-----G 442
+Y GGY QS L +E Y P W +A + RS A V+ G++YA+GG G
Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 443 PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPH 502
++++ Y+P + W A M+ R GVGV+ G I+ VGG +G H +S+ERY+P
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 503 QNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYC 562
+++W + PM R GVG AV++ LY VGG G++ LN+ + Y P + W M
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI 506
Query: 563 RCNFGLTAL 571
R G+ L
Sbjct: 507 RSGAGVCVL 515
Score = 98.6 bits (244), Expect = 1e-20
Identities = 57/148 (38%), Positives = 77/148 (52%), Gaps = 9/148 (6%)
Query: 283 KVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATN 342
++L AVGG G L+S E Y+P+ + W + +N R G+CVL +Y GG
Sbjct: 470 RLLYAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG- 527
Query: 343 VRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQS 402
+ NSVE ++ +T TWT + M RS LG+ V G +Y LGGYDG ++L S
Sbjct: 528 -------QDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDS 580
Query: 403 VEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
VE Y P W V MT+ RS AV
Sbjct: 581 VECYDPDTDTWSEVTRMTSGRSGVGVAV 608
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 352 bits (903), Expect = 5e-97
Identities = 194/552 (35%), Positives = 302/552 (54%), Gaps = 20/552 (3%)
Query: 26 NLLR--QHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDE 83
+LLR ++ ELCD+ L+VG I HK+VLA V PYF+AMF ++E + + +E + D
Sbjct: 56 SLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDG 115
Query: 84 TALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRF 143
A++ +V++ Y+ + ++ D V+ LL AA +LQ++LV + CC +++ P NC+ + F
Sbjct: 116 DAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAF 175
Query: 144 AETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALE 203
AE++ DL A +Y C +F V + E+F ++ L +++S+ LN+ E+ V+ A
Sbjct: 176 AESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAI 235
Query: 204 SWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHF- 262
W+ + Q K+L + L VRLPLL V FL + +++ + C+ LL+EA YH
Sbjct: 236 KWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLH 295
Query: 263 -----MPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPL 317
+P+ S +T T + VL VGG+ G S+E Y +SW +
Sbjct: 296 LSSRAVPDFEYSIRT---TPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEM 352
Query: 318 NIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRS 377
N R G+ ++ KVY +GG N +H S+E ++P TN W MN R
Sbjct: 353 NSRRRHVGVISVEGKVYAVGGHDGN--------EHLGSMEMFDPLTNKWMMKASMNTKRR 404
Query: 378 TLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYA 437
+ + L G +YA+GG D + VE+Y + +W VAPM T R + L +YA
Sbjct: 405 GIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYA 464
Query: 438 IGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSI 496
+GG G A ++SVERYDP D W V M +R GV + G ++VVGG + S LSS+
Sbjct: 465 VGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSV 524
Query: 497 ERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDS 556
ERYDP N+W + PR GVG A + ++ VGGH+G++YLNTV+ +DP+ + W
Sbjct: 525 ERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELV 584
Query: 557 AGMIYCRCNFGL 568
+ +CR G+
Sbjct: 585 GSVSHCRAGAGV 596
Score = 119 bits (297), Expect = 1e-26
Identities = 64/189 (33%), Positives = 102/189 (53%), Gaps = 2/189 (1%)
Query: 385 AGELYALGGYDGQSY-LQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-G 442
AG L+ +GG G +S+E Y W M + R ++G +YA+GG+ G
Sbjct: 317 AGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDG 376
Query: 443 PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPH 502
H+ S+E +DP + W M ASM KR + + G I+ +GG + + + +ERYD
Sbjct: 377 NEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIE 436
Query: 503 QNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYC 562
+QW+ PM PR GVG+ + N++Y VGG+ G + L++V++YDP D W++ M
Sbjct: 437 SDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQR 496
Query: 563 RCNFGLTAL 571
R G++ L
Sbjct: 497 RAGNGVSKL 505
Score = 83.6 bits (205), Expect = 5e-16
Identities = 50/164 (30%), Positives = 82/164 (50%), Gaps = 9/164 (5%)
Query: 287 AVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPG 346
AVGG G+ A L SVE Y P D WI + + R G+ L +YV+GG N
Sbjct: 464 AVGGNDGM-ASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDN---- 518
Query: 347 VTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKY 406
+SVE ++P +N W + + R +G+ + G+++A+GG++G +YL +VE +
Sbjct: 519 ----SPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAF 574
Query: 407 IPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHMNSVE 450
P + +W+ V ++ R+ AV + I G N V+
Sbjct: 575 DPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVD 618
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 332 bits (850), Expect = 7e-91
Identities = 183/492 (37%), Positives = 280/492 (56%), Gaps = 16/492 (3%)
Query: 68 LSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAF 127
+SE V + +D L+ +++Y YT + ++++ V+ LLPAA LLQ++ V K CC F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 128 LESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSN 187
LESQL P NC+GI FA+ + C DL A Y Q+F V +EEF L + ++S+
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 188 DCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDD 247
D L +++EE VF A+ +W+ +D RQ+++A+L+ VRLPLL ++L + E L+++
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 248 RTCKHLLNEALKYHFMP-EHRLSHQTV--LMTRPRCAPKVLCAVGGKSGLFACLDSVEMY 304
CK L EA+KYH +P E R+ ++V + P PK++ VGG++ + SVE Y
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAP--KAIRSVECY 238
Query: 305 FPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTN 364
+ + W +A L R G+ + V+ +GG ++R +V+ ++P +
Sbjct: 239 DFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR--------VRTVDSYDPVKD 290
Query: 365 TWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRS 424
WTS+ M + RSTLG VL G LYA+GG+DG + L SVE Y K +W VAPM T RS
Sbjct: 291 QWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRS 350
Query: 425 CFAAAVLDGMIYAIGGYGPAH---MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFI 481
V+ G++YA+GGY A +++VE Y+ + + W +A M+ +R GVGV+ +
Sbjct: 351 SVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLL 410
Query: 482 FVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLN 541
+ VGGH+G S+E YDP N W M R G ++ LYVVGG GS L
Sbjct: 411 YAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLA 470
Query: 542 TVQKYDPISDTW 553
+V+ Y+P +D W
Sbjct: 471 SVEYYNPTTDKW 482
Score = 101 bits (252), Expect = 2e-21
Identities = 50/138 (36%), Positives = 80/138 (57%)
Query: 431 LDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
L ++ +GG P + SVE YD ++ W VA + +R G+ M G +F VGG NG
Sbjct: 217 LPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 276
Query: 491 SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPIS 550
+ +++ YDP ++QWT M++ R+ +GAAV++ LY VGG GS+ L++V+ Y+ S
Sbjct: 277 LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKS 336
Query: 551 DTWLDSAGMIYCRCNFGL 568
+ W A M R + G+
Sbjct: 337 NEWFHVAPMNTRRSSVGV 354
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 313 bits (802), Expect = 3e-85
Identities = 187/540 (34%), Positives = 285/540 (52%), Gaps = 15/540 (2%)
Query: 26 NLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETA 85
N LR +LCD++++V + AHK +L S S YF+A+FT + E I
Sbjct: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDM 89
Query: 86 LQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAE 145
++ I+EYAYT TV I+ D VE LL AA+ I +++ CC FL+S+L NCIGI +F +
Sbjct: 90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTD 149
Query: 146 TYGCRDLYLAATKYICQNFEAVCQ-TEEFFELTHADLDEIVSNDCLNVATEETVFYALES 204
Y C +L A +I NFE + + + EF EL+ +L +I+ D LNV E+ VF A+
Sbjct: 150 YYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILK 209
Query: 205 WIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHF-- 262
WI +D Q R+++++ LL VRL L+ ++ + N ++D CK ++ ALK +
Sbjct: 210 WISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDL 269
Query: 263 -MPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGL-APLNIP 320
M S T +TRPR +L A+GG SG + +++E Y + D W+ + P
Sbjct: 270 NMNGPSNSDFTNPLTRPRLPYAILFAIGGWSG-GSPTNAIEAYDARADRWVNVTCEEESP 328
Query: 321 RYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLG 380
R G L VY+IGG + + NSV+ ++P TW + M+ R +
Sbjct: 329 RAYHGAAYLKGYVYIIGGFDS--------VDYFNSVKRFDPVKKTWHQVAPMHSRRCYVS 380
Query: 381 VVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGG 440
V VL +YA+GG+DG L + E+Y P+ +W +APM RS +A L G +Y GG
Sbjct: 381 VTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGG 440
Query: 441 Y-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERY 499
+ G + + E Y+ + W ++A M +R GV ++ VGG +G + L S E Y
Sbjct: 441 FNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAY 500
Query: 500 DPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM 559
P N W M PR+ G V+D+ L+VVGG +G + V+ YD +D W D+ M
Sbjct: 501 SPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDM 560
Score = 123 bits (308), Expect = 5e-28
Identities = 66/185 (35%), Positives = 101/185 (54%), Gaps = 2/185 (1%)
Query: 388 LYALGGYDGQSYLQSVEKYIPKIRKWQPVA-PMTTTRSCFAAAVLDGMIYAIGGYGPA-H 445
L+A+GG+ G S ++E Y + +W V + R+ AA L G +Y IGG+ +
Sbjct: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDY 352
Query: 446 MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQ 505
NSV+R+DP K +W VA M +R + V V+ FI+ +GG +G L++ ERY+P NQ
Sbjct: 353 FNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQ 412
Query: 506 WTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCN 565
WT+ PM E R+ A + +Y+ GG +G+ L T + Y+ S+ W A M R
Sbjct: 413 WTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSG 472
Query: 566 FGLTA 570
G+ A
Sbjct: 473 IGVIA 477
Score = 90.5 bits (223), Expect = 4e-18
Identities = 48/156 (30%), Positives = 82/156 (52%), Gaps = 8/156 (5%)
Query: 418 PMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADK-RIHFGVG 475
P+T R +A +++AIGG+ G + N++E YD D W V + R + G
Sbjct: 282 PLTRPRLPYA------ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAA 335
Query: 476 VMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHS 535
+ G+++++GG + V + +S++R+DP + W PM R V V+ N++Y +GG
Sbjct: 336 YLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFD 395
Query: 536 GSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
G LNT ++Y+P ++ W A M R + T L
Sbjct: 396 GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTL 431
Score = 70.9 bits (172), Expect = 3e-12
Identities = 40/140 (28%), Positives = 68/140 (48%), Gaps = 12/140 (8%)
Query: 297 CLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGI--ATNVRPGVTIRKHEN 354
CL + E+Y +++ W +AP+ R G+ + VY +GG A +R
Sbjct: 446 CLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLR---------- 495
Query: 355 SVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQ 414
S E ++P NTW ++ M RS G+ V+ L+ +GG++G + +VE Y K +W
Sbjct: 496 SAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWY 555
Query: 415 PVAPMTTTRSCFAAAVLDGM 434
M+ RS + V+ G+
Sbjct: 556 DAHDMSIYRSALSCCVVPGL 575
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 303 bits (777), Expect = 2e-82
Identities = 193/574 (33%), Positives = 286/574 (49%), Gaps = 27/574 (4%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H++ +L +N +R CD+ L+VG AH++VLA+ SPYF A+FTG + E V
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
I+ Q ++++ YTG V I + V+ L+ AA++LQ+ V+ CC FL+ Q+DP N
Sbjct: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
CIGI +F+E C DL + YI +F V EEF LT L +I+ ++ L++ E
Sbjct: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
VF A WI D+ +R+K++ ++L+ +R PLL + L + E + LL E
Sbjct: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
Query: 257 ALKYHFMPEHR--LSHQTVLMTRPR-CAPKVLCAVGGKSGL-------FACLDSVEMYFP 306
+ P+ S RPR A K L AVGG + L L VE +
Sbjct: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
Query: 307 QNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTW 366
+ W ++ L+ R G+ VL VY IGG ++ T EC++P T W
Sbjct: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT--------ECYDPVTKQW 370
Query: 367 TSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCF 426
T++ MN R LGV V G +YALGG+ G ++E++ P KW+ V M +R F
Sbjct: 371 TTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYF 430
Query: 427 AAAVLDGMIYAIGGYG--PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVV 484
+ G+IY IGG + S E YDP W + M +R + GV + I+ V
Sbjct: 431 GCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSV 490
Query: 485 GGHNGVSH-LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS------ 537
GG N L ++E+Y + +W MK PR G+ ++ LYV GG S S
Sbjct: 491 GGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAP 550
Query: 538 SYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
L++V+ Y+P SDTW + MI RC G+ L
Sbjct: 551 GTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 282 bits (721), Expect = 7e-76
Identities = 179/534 (33%), Positives = 266/534 (49%), Gaps = 21/534 (3%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H++ +L +N +R CD+ L+VG AH++VLA+ SPYF A+FTG + E V
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
I+ Q ++++ YTG V I + V+ L+ AA++LQ+ V+ CC FL+ Q+DP N
Sbjct: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
CIGI +F+E C DL + YI +F V EEF LT L +I+ ++ L++ E
Sbjct: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
VF A WI D+ +R+K++ ++L+ +R PLL + L + E + LL E
Sbjct: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
Query: 257 ALKYHFMPEHR--LSHQTVLMTRPR-CAPKVLCAVGGKSGL-------FACLDSVEMYFP 306
+ P+ S RPR A K L AVGG + L L VE +
Sbjct: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
Query: 307 QNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTW 366
+ W ++ L+ R G+ VL VY IGG ++ T EC++P T W
Sbjct: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT--------ECYDPVTKQW 370
Query: 367 TSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCF 426
T++ MN R LGV V G +YALGG+ G ++E++ P KW+ V M +R F
Sbjct: 371 TTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYF 430
Query: 427 AAAVLDGMIYAIGGYG--PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVV 484
+ G+IY IGG + S E YDP W + M +R + GV + I+ V
Sbjct: 431 GCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSV 490
Query: 485 GGHNGVSH-LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS 537
GG N L ++E+Y + +W MK PR G+ ++ LYV GG S S
Sbjct: 491 GGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
Score = 90.1 bits (222), Expect = 5e-18
Identities = 58/195 (29%), Positives = 92/195 (47%), Gaps = 16/195 (8%)
Query: 275 MTRPRCAPKVLCAVGGKSGLFACL-----DSVEMYFPQNDSWIGLAPLNIPRYEFGICVL 329
M PRC V G L + +++E + P + W + + + RY FG C +
Sbjct: 376 MNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEM 435
Query: 330 DQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELY 389
+YVIGGI+ G+ +R S E ++P + W+ L M R+ LGV L +Y
Sbjct: 436 QGLIYVIGGISNE---GIELR----SFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIY 488
Query: 390 ALGGY-DGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAH--- 445
++GG+ + Q L +VEKY + KW VA M R+ ++G++Y GG +H
Sbjct: 489 SVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFL 548
Query: 446 MNSVERYDPSKDSWE 460
RY+ + WE
Sbjct: 549 APDTHRYEVFRLKWE 563
Score = 84.7 bits (208), Expect = 2e-16
Identities = 45/142 (31%), Positives = 65/142 (45%), Gaps = 9/142 (6%)
Query: 435 IYAIGGYGPAH---------MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVG 485
+YA+GGY ++ VER+D W V+S+ R GV V+ G ++ +G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 486 GHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQK 545
G E YDP QWT M PR G+G V +Y +GG G+ NT+++
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
Query: 546 YDPISDTWLDSAGMIYCRCNFG 567
+DP + W M R FG
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFG 431
Score = 60.8 bits (146), Expect = 3e-09
Identities = 27/97 (27%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 480 FIFVVGGHNGVSH--------LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVV 531
+++ VGG+ + LS +ER+D WT + + R+G+G V+ +Y +
Sbjct: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
Query: 532 GGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
GG S + + YDP++ W A M + RC G+
Sbjct: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGV 385
Score = 32.0 bits (71), Expect = 1.6
Identities = 22/75 (29%), Positives = 32/75 (42%), Gaps = 17/75 (22%)
Query: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGGH--------SGSSYLNTVQKYDPISDTWLDS 556
Q + RP K+ R YLY VGG+ S S L+ V+++D S W
Sbjct: 276 QTSKVRPRKKAR---------KYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTV 326
Query: 557 AGMIYCRCNFGLTAL 571
+ + R G+T L
Sbjct: 327 SSLHQARSGLGVTVL 341
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 275 bits (704), Expect = 6e-74
Identities = 173/539 (32%), Positives = 274/539 (50%), Gaps = 25/539 (4%)
Query: 25 LNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDET 84
+N +R+ LCD+IL V + KI AH+VVLA+ S +F MFT N+ E ++ EVE + +
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
Query: 85 ALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFA 144
++ +VE+AYT + ++ + V+SLL AAN QI+ V K C FL+ Q+D NC+GIS A
Sbjct: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
Query: 145 ETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALES 204
E C +L A +I Q+F V +T+EF +L + +++ D L V E+ V+ A
Sbjct: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
Query: 205 WIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFM- 263
W+KYD RQ ++ +L VR PL+S FL++ +A LI+D+ C ++ ++YH +
Sbjct: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
Query: 264 PEHRLSHQTVLMTRPRCAPK--VLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPR 321
PE R + V TRPR + GG S + P++ SW + R
Sbjct: 274 PEDR--EELVDGTRPRRKKHDYRIALFGGSQP-----QSCRYFNPKDYSWTDIRCPFEKR 326
Query: 322 YEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGV 381
+ D VY++GG + + P I++ ++C+N ++W S R +L
Sbjct: 327 RDAACVFWDNVVYILGG--SQLFP---IKR----MDCYNVVKDSWYSKLGPPTPRDSLAA 377
Query: 382 VVLAGELYALGGYD-GQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGG 440
G++Y GG + G S L E Y + W M T R +G+IY GG
Sbjct: 378 CAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGG 437
Query: 441 -----YGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSS 495
+NS E YDP+ ++W + M + R + G+ + IF VGG NG+ L +
Sbjct: 438 SLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDN 497
Query: 496 IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWL 554
+E YD N+W + PM V A + + +YV+ G G L + +Y+ +D W+
Sbjct: 498 VEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWV 556
Score = 68.2 bits (165), Expect = 2e-11
Identities = 51/178 (28%), Positives = 70/178 (39%), Gaps = 5/178 (2%)
Query: 396 GQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPS 455
G S QS + PK W + R A D ++Y +GG + ++ Y+
Sbjct: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVV 358
Query: 456 KDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN-GVSHLSSIERYDPHQNQWTVCRPMKE 514
KDSW R G I+ GG G S L E YD W M
Sbjct: 359 KDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLT 418
Query: 515 PRTGVGAAVIDNYLYVVGGHSGSSY----LNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
R G + +YV GG G++ LN+ + YDP ++TW + MI R N GL
Sbjct: 419 QRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGL 476
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 271 bits (693), Expect = 1e-72
Identities = 171/530 (32%), Positives = 269/530 (50%), Gaps = 25/530 (4%)
Query: 34 LCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYA 93
LCD+IL V + KI AH+VVLA+ S +F MFT N+ E ++ EVE + + ++ +VE+A
Sbjct: 21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA 80
Query: 94 YTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFAETYGCRDLY 153
YT + ++ + V+SLL AAN QI+ V K C FL+ Q+D NC+GIS AE C +L
Sbjct: 81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELK 140
Query: 154 LAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALESWIKYDVQER 213
A +I Q+F V +T+EF +L + +++ D L V E+ V+ A W+KYD R
Sbjct: 141 ATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNR 200
Query: 214 QKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFM-PEHRLSHQT 272
Q ++ +L VR PL+S FL++ +A LI+D+ C ++ ++YH + PE R +
Sbjct: 201 QPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDR--EEL 258
Query: 273 VLMTRPRCAPK--VLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLD 330
V TRPR + GG S + P++ SW + R + D
Sbjct: 259 VDGTRPRRKKHDYRIALFGGSQP-----QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWD 313
Query: 331 QKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYA 390
VY++GG + + P I++ ++C+N ++W S R +L G++Y
Sbjct: 314 NVVYILGG--SQLFP---IKR----MDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYT 364
Query: 391 LGGYD-GQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGG-----YGPA 444
GG + G S L E Y + W M T R +G+IY GG
Sbjct: 365 SGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGR 424
Query: 445 HMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQN 504
+NS E YDP+ ++W + M + R + G+ + IF VGG NG+ L ++E YD N
Sbjct: 425 VLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLN 484
Query: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWL 554
+W + PM V A + + +YV+ G G L + +Y+ +D W+
Sbjct: 485 EWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWV 534
Score = 68.2 bits (165), Expect = 2e-11
Identities = 51/178 (28%), Positives = 70/178 (39%), Gaps = 5/178 (2%)
Query: 396 GQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPS 455
G S QS + PK W + R A D ++Y +GG + ++ Y+
Sbjct: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVV 336
Query: 456 KDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN-GVSHLSSIERYDPHQNQWTVCRPMKE 514
KDSW R G I+ GG G S L E YD W M
Sbjct: 337 KDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLT 396
Query: 515 PRTGVGAAVIDNYLYVVGGHSGSSY----LNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
R G + +YV GG G++ LN+ + YDP ++TW + MI R N GL
Sbjct: 397 QRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGL 454
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 269 bits (688), Expect = 4e-72
Identities = 177/551 (32%), Positives = 277/551 (50%), Gaps = 16/551 (2%)
Query: 14 THLHSEQLLQGLNLLRQHHELCDIILRVGDVK--IHAHKVVLASVSPYFKAMFTGNLSEK 71
++ HS +LQG + LR LCD+ L GD H+ ++AS S YFKAMFTG + E+
Sbjct: 29 SNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQ 88
Query: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131
+ ++ +++ L+ I+++ YT + ++ D ++ L AA+ LQI VL C FL S
Sbjct: 89 DLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 148
Query: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191
+ NC+ + R A TY ++ +I +NF A+ T EF +L L ++S++ L
Sbjct: 149 VSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLK 208
Query: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
TE +F A W++ + R Y A+L+ ++R PL++ + L + +R D TC
Sbjct: 209 HCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCV 267
Query: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGG-KSGLFACLDSVEMYFPQNDS 310
+LL EA Y MP + Q+ T R L +GG + MY +
Sbjct: 268 NLLLEASNYQMMPYMQPVMQSD-RTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQE 326
Query: 311 WIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370
W LAP++ PRY+ GI V+ +YV+GG + G T ++V ++P N W +
Sbjct: 327 WRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTA---VDTVFRFDPRYNKWMQVA 383
Query: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
+NE R+ + L G LYA+GG L +VE Y P++ +W VA M+ A V
Sbjct: 384 SLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTV 443
Query: 431 LDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN- 488
G++Y GG N + +DP D W A M R + + ++V+GG++
Sbjct: 444 YGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHF 503
Query: 489 -GVS---HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSS--YLNT 542
G S + S E Y P +QWT M ++ VG AV +N +YVVGG+S ++ +
Sbjct: 504 RGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 563
Query: 543 VQKYDPISDTW 553
VQKYDP D W
Sbjct: 564 VQKYDPEKDEW 574
Score = 110 bits (275), Expect = 3e-24
Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 13/193 (6%)
Query: 388 LYALGGYDGQSYLQSVE--KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY---- 441
L LGG Q + S E Y + ++W+ +APM R AV+ +Y +GG
Sbjct: 300 LVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD 359
Query: 442 --GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERY 499
G +++V R+DP + W VAS+ +KR F + + G ++ VGG + L+++E Y
Sbjct: 360 TKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECY 419
Query: 500 DPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM 559
+P N+W+ M EP G V +Y+ GG + ++ N + +DP +D W+ A M
Sbjct: 420 NPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPM 479
Query: 560 -----IYCRCNFG 567
++C C G
Sbjct: 480 TTVRGLHCMCTVG 492
Score = 88.6 bits (218), Expect = 1e-17
Identities = 58/191 (30%), Positives = 89/191 (46%), Gaps = 17/191 (8%)
Query: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
L AVGG+S L +VE Y P+ + W +A ++ P Y V +Y+ GGI +
Sbjct: 401 LYAVGGRSAAGE-LATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDT- 458
Query: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGG--YDGQSYLQS 402
+N + C++PDT+ W M R + + +LY +GG + G S
Sbjct: 459 -------FQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDD 511
Query: 403 V---EKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYG---PAHMNSVERYDPSK 456
V E Y P + +W P+A M +S AV + IY +GGY + V++YDP K
Sbjct: 512 VLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEK 571
Query: 457 DSWEMVASMAD 467
D W V + +
Sbjct: 572 DEWHKVFDLPE 582
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/81 (38%), Positives = 43/81 (53%), Gaps = 5/81 (6%)
Query: 496 IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHS-----GSSYLNTVQKYDPIS 550
+ YD +W PM PR G AVI N+LYVVGG S G + ++TV ++DP
Sbjct: 317 LRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRY 376
Query: 551 DTWLDSAGMIYCRCNFGLTAL 571
+ W+ A + R F L+AL
Sbjct: 377 NKWMQVASLNEKRTFFHLSAL 397
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 266 bits (680), Expect = 4e-71
Identities = 175/551 (31%), Positives = 277/551 (50%), Gaps = 16/551 (2%)
Query: 14 THLHSEQLLQGLNLLRQHHELCDIILRVGDVK--IHAHKVVLASVSPYFKAMFTGNLSEK 71
++ HS +LQG + LR LCD+ L GD H+V++AS S YFKAMFTG + E+
Sbjct: 71 SNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMKEQ 130
Query: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131
+ ++ + + L+ I+++ YT + ++ D ++ L AA+ LQI VL C FL S
Sbjct: 131 DLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 190
Query: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191
+ NC+ + R A TY ++ ++ +NF A+ T EF +L L ++S++ L
Sbjct: 191 VTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNSLK 250
Query: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
TE +F A W++ + + R + A+L+ ++R PL++ + L + +R D TC
Sbjct: 251 HCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNTCV 309
Query: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGG-KSGLFACLDSVEMYFPQNDS 310
+LL EA Y MP + Q+ T R L +GG + MY +
Sbjct: 310 NLLLEASNYQMMPYMQPVMQSD-RTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHE 368
Query: 311 WIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370
W LAP++ PRY+ GI V+ +YV+GG + G T ++V ++P N W +
Sbjct: 369 WKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTA---VDTVFRFDPRYNKWMQVA 425
Query: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
+NE R+ + L G LYA+GG + L +VE Y P+ +W VA M+ A V
Sbjct: 426 SLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTV 485
Query: 431 LDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN- 488
G++Y GG + +DP D W A M R + + ++V+GG++
Sbjct: 486 YGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHF 545
Query: 489 -GVS---HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSS--YLNT 542
G S + S E Y P +QWT M ++ VG AV +N +YVVGG+S ++ +
Sbjct: 546 RGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 605
Query: 543 VQKYDPISDTW 553
VQKYDP D W
Sbjct: 606 VQKYDPDKDEW 616
Score = 112 bits (281), Expect = 7e-25
Identities = 60/193 (31%), Positives = 94/193 (48%), Gaps = 13/193 (6%)
Query: 388 LYALGGYDGQSYLQSVE--KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY---- 441
L LGG Q + S E Y K +W+ +APM R AV+ +Y +GG
Sbjct: 342 LVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD 401
Query: 442 --GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERY 499
G +++V R+DP + W VAS+ +KR F + + G+++ VGG N L ++E Y
Sbjct: 402 TKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECY 461
Query: 500 DPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM 559
+P N+WT M EP G V +Y+ GG + ++ + +DP +D W+ A M
Sbjct: 462 NPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPM 521
Query: 560 -----IYCRCNFG 567
++C C G
Sbjct: 522 TTVRGLHCMCTVG 534
Score = 94.7 bits (234), Expect = 2e-19
Identities = 63/221 (28%), Positives = 106/221 (47%), Gaps = 11/221 (4%)
Query: 359 WNPDTNTWTSLERMNESRSTLGVVVLAGELYALGG---YD--GQSYLQSVEKYIPKIRKW 413
++ + W SL M+ R G+ V+ LY +GG YD G++ + +V ++ P+ KW
Sbjct: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Query: 414 QPVAPMTTTRSCFAAAVLDGMIYAIGGYGPA-HMNSVERYDPSKDSWEMVASMADKRIHF 472
VA + R+ F + L G +YA+GG A + +VE Y+P + W VA M++
Sbjct: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
Query: 473 GVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVG 532
V G +++ GG + + +DP ++W PM R + LYV+G
Sbjct: 482 AGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIG 541
Query: 533 GHS--GSSYLNTV---QKYDPISDTWLDSAGMIYCRCNFGL 568
G+ G+S + V + Y PI D W A M+ + + G+
Sbjct: 542 GNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582
Score = 85.1 bits (209), Expect = 2e-16
Identities = 56/191 (29%), Positives = 87/191 (45%), Gaps = 17/191 (8%)
Query: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
L AVGG++ L +VE Y P+ + W +A ++ P Y V +Y+ GGI +
Sbjct: 443 LYAVGGRNAAGE-LPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDT- 500
Query: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGG--YDGQSYLQS 402
+ + C++PDT+ W M R + + LY +GG + G S
Sbjct: 501 -------FQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDD 553
Query: 403 V---EKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYG---PAHMNSVERYDPSK 456
V E Y P + +W P+A M +S AV + IY +GGY + V++YDP K
Sbjct: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613
Query: 457 DSWEMVASMAD 467
D W V + +
Sbjct: 614 DEWHKVFDLPE 624
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/81 (38%), Positives = 44/81 (54%), Gaps = 5/81 (6%)
Query: 496 IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHS-----GSSYLNTVQKYDPIS 550
+ YD ++W PM PR G AVI N+LYVVGG S G + ++TV ++DP
Sbjct: 359 LRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRY 418
Query: 551 DTWLDSAGMIYCRCNFGLTAL 571
+ W+ A + R F L+AL
Sbjct: 419 NKWMQVASLNEKRTFFHLSAL 439
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 266 bits (679), Expect = 5e-71
Identities = 168/551 (30%), Positives = 275/551 (49%), Gaps = 21/551 (3%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENS-- 74
+ LL+GL+ +RQ + LCD+++ HK V+AS S YF N+ +K+ S
Sbjct: 55 YGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFY-----NILKKDPSIQ 109
Query: 75 EVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDP 134
V+ I L ++ YAYTG + +S T+ S++ AA LQI ++K C FL ++
Sbjct: 110 RVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSV 169
Query: 135 GNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVAT 194
NC+ + AETY ++ AA K+I NF ++++F +LT ++E++ +D L + +
Sbjct: 170 ENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLPS 229
Query: 195 EETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLL 254
E F W+++D Q+R KY A LL+++R +S + L ++ + D C LL
Sbjct: 230 EIVAFQIAMKWLEFD-QKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLL 288
Query: 255 NEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLF-ACLDSVEMYFPQNDSWIG 313
+A+ YH +P H+ + Q+ TR R +VL VGG+ GL L +Y + W
Sbjct: 289 VDAMNYHLLPYHQNTLQS-RRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWSK 347
Query: 314 LAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVEC-WNPDTNTWTSLERM 372
L + + + V+D +YV GG N KH S C ++P NTW L M
Sbjct: 348 LTEMPAKSFNQCVAVMDGFLYVAGGEDQN--DARNQAKHAVSNFCRYDPRFNTWIHLASM 405
Query: 373 NESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLD 432
N+ R+ + V G +YA GG + + L S+E Y+P +WQP P+ R C A+AV D
Sbjct: 406 NQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVAD 465
Query: 433 GMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGG----- 486
G + GGY A+ SV YDP+ DSW+ + +++ R + ++V+GG
Sbjct: 466 GRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGP 525
Query: 487 HNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG--HSGSSYLNTVQ 544
+ ++E Y P QW+ P++ + G + + Y+VGG Y +Q
Sbjct: 526 RGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQ 585
Query: 545 KYDPISDTWLD 555
+ P + W +
Sbjct: 586 CFSPELNEWTE 596
Score = 60.1 bits (144), Expect = 5e-09
Identities = 38/141 (26%), Positives = 61/141 (43%), Gaps = 10/141 (7%)
Query: 434 MIYAIGGYGPAHMNSVER---YDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH--- 487
++ +GG S+ R Y ++ W + M K + V VM GF++V GG
Sbjct: 317 VLVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQN 376
Query: 488 ---NGVSH-LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTV 543
N H +S+ RYDP N W M + RT +V + +Y GG + L ++
Sbjct: 377 DARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASL 436
Query: 544 QKYDPISDTWLDSAGMIYCRC 564
+ Y P ++ W + RC
Sbjct: 437 ECYVPSTNQWQPKTPLEVARC 457
Score = 43.9 bits (102), Expect = 4e-04
Identities = 23/82 (28%), Positives = 41/82 (50%), Gaps = 8/82 (9%)
Query: 300 SVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECW 359
+VE Y P W APL + G+ L + Y++GG + K++ ++C+
Sbjct: 534 TVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEK------KYKKCIQCF 587
Query: 360 NPDTNTWTSLERMNESRSTLGV 381
+P+ N WT + + E +T+GV
Sbjct: 588 SPELNEWTEDDELPE--ATVGV 607
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/98 (29%), Positives = 43/98 (43%), Gaps = 9/98 (9%)
Query: 481 IFVVGGHNGVSH--LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSS 538
+ VGG G++ LS Y +N W+ M AV+D +LYV GG +
Sbjct: 318 LVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQND 377
Query: 539 YLNTVQ-------KYDPISDTWLDSAGMIYCRCNFGLT 569
N + +YDP +TW+ A M R +F L+
Sbjct: 378 ARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLS 415
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 263 bits (671), Expect = 4e-70
Identities = 177/553 (32%), Positives = 267/553 (48%), Gaps = 32/553 (5%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
H+E +LQ N R D+I+ V + H+ VL++ S YF+AMF + E V
Sbjct: 48 HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLV 107
Query: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
E I A++ ++Y YTG V I+ + V+ L ++L QI ++ C FLE QLDP N
Sbjct: 108 EINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCN 167
Query: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
C+GI RFA+T+ + L+ + Q FE V Q EEF EL +L + + +D L + EE
Sbjct: 168 CLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227
Query: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
VF A+ W+ V R+ L +LL VRLPLL + + E + LI++ C LL+E
Sbjct: 228 MVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHE 287
Query: 257 ALKYHFMPEHRLSHQTVLMTRPRCA---PKVLCAVGG--KSGLFACLDSVEMYFPQNDSW 311
A +YH + +S + TRPR + +V+ VGG + G F L E Y P W
Sbjct: 288 ARRYHILGNEMMSPR----TRPRRSTGYSEVIVVVGGCERVGGFN-LPYTECYDPVTGEW 342
Query: 312 IGLAPL-NIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370
LA L + E+ +C L + V GG R + V +N N W +
Sbjct: 343 KSLAKLPEFTKSEYAVCALRNDILVSGG-----------RINSRDVWIYNSQLNIWIRVA 391
Query: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
+N+ R + VL G++Y +GGYDGQ+ L SVE Y +W VAP+ S A
Sbjct: 392 SLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTS 451
Query: 431 LDGMIYAIGGYGP---AHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH 487
G ++ IGG GP + V+ YDP +SW + A++ + + I+V GG
Sbjct: 452 CVGKLFVIGG-GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL 510
Query: 488 NGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG-HSGSSYLNTVQKY 546
+I YDP ++ W + + G +V + +Y++GG +T+ Y
Sbjct: 511 T-----KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCY 565
Query: 547 DPISDTWLDSAGM 559
DP + A M
Sbjct: 566 DPATSIITGVAAM 578
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 248 bits (633), Expect = 1e-65
Identities = 169/553 (30%), Positives = 263/553 (47%), Gaps = 31/553 (5%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
+++ +L LNLLRQ D++L G+ H+ VLA+ S YF+AMF+G L E ++SEV
Sbjct: 28 YADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEV 87
Query: 77 EFQ-CIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPG 135
F I L+ +++YAY+ V I+++ ESLL A ++L+ + + C FLE L P
Sbjct: 88 NFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPT 147
Query: 136 NCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATE 195
NC+G+ ++ + C LY + + NF+ + + E+F +L + +++S++ L E
Sbjct: 148 NCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDE 207
Query: 196 ETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLN 255
V+ + +WI YD+++R YL +LL +VRL LL +L LI R K ++
Sbjct: 208 RLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVE 267
Query: 256 EALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLA 315
EA++ T L RPR L +GG++ F C D + + + I A
Sbjct: 268 EAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQT--FMC-DKLYLVDQKAKEIIPKA 324
Query: 316 PLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSV--ECWNPDT--NTWTSLER 371
+ PR EF C + KVY+ GG R EN V + W DT W+
Sbjct: 325 DIPSPRKEFSACAIGCKVYITGG-----------RGSENGVSKDVWVYDTLHEEWSKAAP 373
Query: 372 MNESRSTLGVVVLAGELYALGGYDGQS---------YLQSVEKYIPKIRKWQPVAPMTTT 422
M +R G L LY +GG+ + L+ VE Y P I KW VAP+
Sbjct: 374 MLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREG 433
Query: 423 RSCFAAAVLDGMIYAIGGYGPAH--MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGF 480
S A ++A GG +H + V+ YD ++ W + A+ + V+
Sbjct: 434 VSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQ 493
Query: 481 IFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYL 540
IF++GG S S+ +++ QWT + R A N LYVVGG+ G
Sbjct: 494 IFIMGGDTEFSACSAY-KFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRC 552
Query: 541 NTVQKYDPISDTW 553
T+ YDP D W
Sbjct: 553 KTLDCYDPTLDVW 565
Score = 40.4 bits (93), Expect = 0.004
Identities = 31/132 (23%), Positives = 51/132 (38%), Gaps = 9/132 (6%)
Query: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
L A GG S L V+ Y + W A P VL +++++GG
Sbjct: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG------ 499
Query: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404
S +N +T WT + + R + V +LY +GGY G ++++
Sbjct: 500 ---DTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLD 556
Query: 405 KYIPKIRKWQPV 416
Y P + W +
Sbjct: 557 CYDPTLDVWNSI 568
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 247 bits (630), Expect = 2e-65
Identities = 166/555 (29%), Positives = 260/555 (46%), Gaps = 33/555 (5%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSE-----K 71
H ++L+ LN R+ D+ + V + H+ VLAS S YFK + ++ + +
Sbjct: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
Query: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131
E E+ + L+ ++E+ YTG++ I ++LL AA+ Q K C +FLE Q
Sbjct: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Query: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191
L NC+G+ AE C +LY A + Q F V EE ++ D VSND LN
Sbjct: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
Query: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
EE V+ + WIK D R +Y A+LL VRLP + +L + + LI+ C+
Sbjct: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
Query: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCA---PKVLCAVGGKSGL---FACLDSVEMYF 305
L+NEA +YH +P R QT TRPR + +V+ VGG+ + L +V +
Sbjct: 551 DLVNEAKRYHMLPHARQEMQTP-RTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWN 609
Query: 306 PQNDSWIGLAPLNIPRYE---FGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPD 362
PQN+ W LA ++P Y+ F + +Y+ GG+ + GVT+ V C+
Sbjct: 610 PQNNKWYPLA--SLPFYDREFFSVVSAGDNIYLSGGMES----GVTLA----DVWCYMSL 659
Query: 363 TNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTT 422
+ W + RM R +V G++Y LGG + VE+Y +W+ VAP+
Sbjct: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKA 719
Query: 423 RSCFAAAVLDGMIYAIGGYGPAHMNS--VERYDPSKDSWEMVASMADKRIHFGVGVMLGF 480
AA V G IY GG A + ++ Y P ++W + S + + GF
Sbjct: 720 VHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGF 779
Query: 481 IFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG--HSGSS 538
+F++GG ++ + YDP + M R A V+D +Y GG S
Sbjct: 780 VFILGG----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGP 835
Query: 539 YLNTVQKYDPISDTW 553
L ++ Y+P ++TW
Sbjct: 836 ALGNMEAYEPTTNTW 850
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 247 bits (630), Expect = 2e-65
Identities = 166/555 (29%), Positives = 260/555 (46%), Gaps = 33/555 (5%)
Query: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSE-----K 71
H ++L+ LN R+ D+ + V + H+ VLAS S YFK + ++ + +
Sbjct: 311 HPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGR 370
Query: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131
E E+ + L+ ++E+ YTG++ I ++LL AA+ Q K C +FLE Q
Sbjct: 371 EKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQ 430
Query: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191
L NC+G+ AE C +LY A + Q F V EE ++ D VSND LN
Sbjct: 431 LTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLN 490
Query: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
EE V+ + WIK D R +Y A+LL VRLP + +L + + LI+ C+
Sbjct: 491 TKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACR 550
Query: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCA---PKVLCAVGGKSGL---FACLDSVEMYF 305
L+NEA +YH +P R QT TRPR + +V+ VGG+ + L +V +
Sbjct: 551 DLVNEAKRYHMLPHARQEMQTP-RTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWN 609
Query: 306 PQNDSWIGLAPLNIPRYE---FGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPD 362
PQN+ W LA ++P Y+ F + +Y+ GG+ + GVT+ V C+
Sbjct: 610 PQNNKWYPLA--SLPFYDREFFSVVSAGDNIYLSGGMES----GVTLA----DVWCYMSL 659
Query: 363 TNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTT 422
+ W + RM R +V G++Y LGG + VE+Y +W+ VAP+
Sbjct: 660 LDNWNLVSRMTVPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKA 719
Query: 423 RSCFAAAVLDGMIYAIGGYGPAHMNS--VERYDPSKDSWEMVASMADKRIHFGVGVMLGF 480
AA V G IY GG A + ++ Y P ++W + S + + GF
Sbjct: 720 VHSAAATVCGGKIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGF 779
Query: 481 IFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG--HSGSS 538
+F++GG ++ + YDP + M R A V+D +Y GG S
Sbjct: 780 VFILGG----AYARATTIYDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGP 835
Query: 539 YLNTVQKYDPISDTW 553
L ++ Y+P ++TW
Sbjct: 836 ALGNMEAYEPTTNTW 850
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,370,070
Number of Sequences: 37866
Number of extensions: 926611
Number of successful extensions: 3349
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 1753
Number of HSP's gapped (non-prelim): 462
length of query: 571
length of database: 18,247,518
effective HSP length: 108
effective length of query: 463
effective length of database: 14,157,990
effective search space: 6555149370
effective search space used: 6555149370
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.