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Search of human proteins with 40807500
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40807500 kelch-like 20 [Homo sapiens]
(609 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40807500 kelch-like 20 [Homo sapiens] 1240 0.0
gi|38194229 kelch-like 17 [Homo sapiens] 541 e-154
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 508 e-144
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 508 e-144
gi|14780904 kelch-like 1 protein [Homo sapiens] 495 e-140
gi|11056006 kelch-like 12 [Homo sapiens] 485 e-137
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 478 e-135
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 469 e-132
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 469 e-132
gi|166235129 kelch-like 3 [Homo sapiens] 468 e-132
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 466 e-131
gi|34101268 kelch-like 8 [Homo sapiens] 460 e-129
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 459 e-129
gi|55925604 kelch-like 18 [Homo sapiens] 459 e-129
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 446 e-125
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 412 e-115
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 393 e-109
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 393 e-109
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 382 e-106
gi|148664209 kelch-like 10 [Homo sapiens] 369 e-102
gi|223890235 intracisternal A particle-promoted polypeptide isof... 364 e-100
gi|40018614 DRE1 protein [Homo sapiens] 314 1e-85
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 299 4e-81
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 291 9e-79
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 286 5e-77
gi|24308181 kelch-like 9 [Homo sapiens] 283 2e-76
gi|45643138 kelch-like 13 [Homo sapiens] 283 4e-76
gi|109150407 kelch-like 6 [Homo sapiens] 282 7e-76
gi|55925608 kelch-like 21 [Homo sapiens] 274 2e-73
gi|8922854 kelch-like 26 [Homo sapiens] 273 4e-73
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 1240 bits (3209), Expect = 0.0
Identities = 609/609 (100%), Positives = 609/609 (100%)
Query: 1 MEGKPMRRCTNIRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINL 60
MEGKPMRRCTNIRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINL
Sbjct: 1 MEGKPMRRCTNIRPGETGMDVTSRCTLGDPNKLPEGVPQPARMPYISDKHPRQTLEVINL 60
Query: 61 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAME 120
LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAME
Sbjct: 61 LRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAME 120
Query: 121 LLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTH 180
LLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTH
Sbjct: 121 LLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTH 180
Query: 181 SCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVK 240
SCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVK
Sbjct: 181 SCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVK 240
Query: 241 YSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQER 300
YSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQER
Sbjct: 241 YSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQER 300
Query: 301 PLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGV 360
PLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGV
Sbjct: 301 PLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGV 360
Query: 361 SVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGG 420
SVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGG
Sbjct: 361 SVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGG 420
Query: 421 QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERY 480
QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERY
Sbjct: 421 QDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERY 480
Query: 481 NPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAM 540
NPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAM
Sbjct: 481 NPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAM 540
Query: 541 TSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIK 600
TSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIK
Sbjct: 541 TSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIK 600
Query: 601 MTHCESHIW 609
MTHCESHIW
Sbjct: 601 MTHCESHIW 609
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 541 bits (1393), Expect = e-154
Identities = 277/555 (49%), Positives = 374/555 (67%), Gaps = 1/555 (0%)
Query: 47 SDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQ 106
S +H ++ +R+ LCD+VL V AK+I AH+V+L++CSPYF AMFT E++ESRQ
Sbjct: 71 SKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQ 130
Query: 107 TEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLD 166
T V + DID +A++ L+ FAYT++I V EGNVQTLLPAA LLQL +++ACC+FL QLD
Sbjct: 131 THVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLD 190
Query: 167 PSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVR 226
PSNCLGIR FAD HSC +LL+ A ++ +F +V ++EEFMLLP Q+++++SSD LNV
Sbjct: 191 PSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVP 250
Query: 227 SEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDL 286
SEE+V+ AV++WVK+ + RR +P++++ VRLPLLS FL+G V ++ L++ +C+DL
Sbjct: 251 SEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDL 310
Query: 287 VDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWR 346
+ EA + LLP++R ++ RTRPR+ G VLFAVGG E YD +T+ W
Sbjct: 311 LIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWH 370
Query: 347 MVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSV 406
+VASMS RR VGV+ + + LYAVGG+DG+S L +VE YDP TN W +V+ T R+ +
Sbjct: 371 VVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVS-MGTRRSCL 429
Query: 407 GVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVG 466
GVA L G LY+ GG DG SCLN ERYDP WT VA+MSTRR V VA L G LYAVG
Sbjct: 430 GVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVG 489
Query: 467 GSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAER 526
G D +S L TVE+Y PQ N W +A M +RR G AV + +Y GG D T+ L+S ER
Sbjct: 490 GYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVER 549
Query: 527 YNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 586
Y+P+ W V M RRS L ++G L AVGG DG++ L +IE ++P N W
Sbjct: 550 YSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASC 609
Query: 587 MNYRRLGGGVGVIKM 601
M RR GV V+++
Sbjct: 610 MFTRRSSVGVAVLEL 624
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 508 bits (1309), Expect = e-144
Identities = 254/558 (45%), Positives = 373/558 (66%), Gaps = 10/558 (1%)
Query: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
H QT + + +H++LCDV+LV G ++I AHR++LS+ S YF AMFT ++ E+RQ E+
Sbjct: 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 215
Query: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
+ ++ ++ LI +AYT ++ ++E N++ LL ACLLQL+++ EACC+FL +QL PSN
Sbjct: 216 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 275
Query: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
CLGIR+FAD C +L ++A +T +F EV+ ++EF+LLPA+++ +++SD++N+ +EE
Sbjct: 276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 335
Query: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
+ NA++ WV++ +++RR L ++L ++RLPLL+P+FL + ++ L + D EC+ L+ E
Sbjct: 336 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIECQKLIME 394
Query: 290 AKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVA 349
A Y LLP+ RP++Q PRT+PRK LFAVGG S +S+E+YD +TN W VA
Sbjct: 395 AMKYHLLPERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA 452
Query: 350 SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVA 409
+M+ RR GV+VLDD LY VGG DG LN+VE Y+PKT WS + P ST R +GVA
Sbjct: 453 NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSV-MPPMSTHRHGLGVA 511
Query: 410 VLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD 469
VL G +YAVGG DG S LN VER+DP+ +W VA+MST R V VAVL G LYAVGG D
Sbjct: 512 VLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD 571
Query: 470 GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD-----TTELSS- 523
G+S L +VE ++P N+W A M RR +G + ++YA+GG D T+ LS
Sbjct: 572 GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDC 631
Query: 524 AERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRL 583
ERY+P+T+ W+ V +M+ R VG+ ++ +L AVGG+DG YL T+E +DP N W
Sbjct: 632 VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQ 691
Query: 584 YGGMNYRRLGGGVGVIKM 601
+ R G V +K+
Sbjct: 692 VAPLCLGRAGACVVTVKL 709
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 508 bits (1309), Expect = e-144
Identities = 254/558 (45%), Positives = 373/558 (66%), Gaps = 10/558 (1%)
Query: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
H QT + + +H++LCDV+LV G ++I AHR++LS+ S YF AMFT ++ E+RQ E+
Sbjct: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
Query: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
+ ++ ++ LI +AYT ++ ++E N++ LL ACLLQL+++ EACC+FL +QL PSN
Sbjct: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
Query: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
CLGIR+FAD C +L ++A +T +F EV+ ++EF+LLPA+++ +++SD++N+ +EE
Sbjct: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
Query: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
+ NA++ WV++ +++RR L ++L ++RLPLL+P+FL + ++ L + D EC+ L+ E
Sbjct: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIECQKLIME 440
Query: 290 AKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVA 349
A Y LLP+ RP++Q PRT+PRK LFAVGG S +S+E+YD +TN W VA
Sbjct: 441 AMKYHLLPERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA 498
Query: 350 SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVA 409
+M+ RR GV+VLDD LY VGG DG LN+VE Y+PKT WS + P ST R +GVA
Sbjct: 499 NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSV-MPPMSTHRHGLGVA 557
Query: 410 VLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD 469
VL G +YAVGG DG S LN VER+DP+ +W VA+MST R V VAVL G LYAVGG D
Sbjct: 558 VLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD 617
Query: 470 GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD-----TTELSS- 523
G+S L +VE ++P N+W A M RR +G + ++YA+GG D T+ LS
Sbjct: 618 GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDC 677
Query: 524 AERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRL 583
ERY+P+T+ W+ V +M+ R VG+ ++ +L AVGG+DG YL T+E +DP N W
Sbjct: 678 VERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQ 737
Query: 584 YGGMNYRRLGGGVGVIKM 601
+ R G V +K+
Sbjct: 738 VAPLCLGRAGACVVTVKL 755
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 495 bits (1274), Expect = e-140
Identities = 257/562 (45%), Positives = 356/562 (63%), Gaps = 10/562 (1%)
Query: 45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAES 104
Y + H QT + K ++LCDV+L+VG +KI AHR++LS+ S YF AMFT ++ E+
Sbjct: 189 YQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEA 248
Query: 105 RQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQ 164
+Q E+ + ID A+ L+ FAYT + ++E ++ LL AACLLQL ++ E CC FL +
Sbjct: 249 KQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKL 308
Query: 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELN 224
L PSNCLGIRAFAD C EL+++A +T N EV+ ++EF+LLPA +L +++SD++N
Sbjct: 309 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVN 368
Query: 225 VRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECR 284
V EE +F+A+M WVKY +Q R L +L +RLPLL P+ L + + L K+D EC+
Sbjct: 369 VPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQIL-ADLENHALFKNDLECQ 427
Query: 285 DLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNE 344
L+ EA Y LLP+ R LMQ PRT+PRK L+AVGG + +++E+YD +TN
Sbjct: 428 KLILEAMKYHLLPERRTLMQSPRTKPRK--STVGTLYAVGGMDNNKGATTIEKYDLRTNL 485
Query: 345 WRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRT 404
W M+ RR GV+V+DD L+ +GG DG LN+VE Y+PKT W+ + P ST R
Sbjct: 486 WIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTV-LPPMSTHRH 544
Query: 405 SVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYA 464
+GV VL G +YAVGG DG S LN VER+DP+ +WT VASMS R V VA L G LY+
Sbjct: 545 GLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYS 604
Query: 465 VGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTE---- 520
VGG DG+S L+++E Y+P N+W+ APM RR +G A +YAVGG D
Sbjct: 605 VGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCS 664
Query: 521 --LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDA 578
L ERY+P+T+ W+ V ++ R VG+ ++ +L AVGG+DG TYL T+E +DP
Sbjct: 665 RLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQT 724
Query: 579 NTWRLYGGMNYRRLGGGVGVIK 600
N W +N R G V VIK
Sbjct: 725 NEWTQMASLNIGRAGACVVVIK 746
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 485 bits (1248), Expect = e-137
Identities = 251/559 (44%), Positives = 353/559 (63%), Gaps = 7/559 (1%)
Query: 46 ISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR 105
+++ H + L +N LRK LCDV L V K AHR++L+ACS YF AMFT EL+E
Sbjct: 11 MTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKG 70
Query: 106 QTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQL 165
+ V I+ + ME+L+DF YT + V NVQ LLPAACLLQL +++ACCEFL+ QL
Sbjct: 71 KPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQL 130
Query: 166 DPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNV 225
DPSNCLGIR FA+TH+C +L++ A+ F+Q +F EV++ EEF+LL ++ +I DE+ V
Sbjct: 131 DPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQV 190
Query: 226 RSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRD 285
SEE VF AV+ WVK++ +ER LP +LQ+VR+PLL+P+++ + ++P I+ +CRD
Sbjct: 191 DSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRD 250
Query: 286 LVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDA-ISSVERYDPQTNE 344
LVDEAK + L P+ R MQGPRTR R + EVL VGG+ S + I VE+YDP+T E
Sbjct: 251 LVDEAKKFHLRPELRSQMQGPRTRAR--LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQE 308
Query: 345 WRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQ---WSSDVAPTST 401
W + S++++R V L D +Y +GG+DG S L+SVE D ++ W S VAP +
Sbjct: 309 WSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYS-VAPMNV 367
Query: 402 CRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGF 461
R G LG +Y GG DG +ERYDP ++W+ + M T R G + V G
Sbjct: 368 RRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGV 427
Query: 462 LYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTEL 521
+Y +GG DG + LN+VE+Y+P W + PM T+R G A+ D IY VGG D T L
Sbjct: 428 IYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHL 487
Query: 522 SSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 581
SS E YN RT+ W+ V +MT+ R VG V+ G+L A+ G+DG + L +IE +DP ++W
Sbjct: 488 SSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW 547
Query: 582 RLYGGMNYRRLGGGVGVIK 600
+ M +R GV V++
Sbjct: 548 EVVTSMGTQRCDAGVCVLR 566
Score = 158 bits (400), Expect = 1e-38
Identities = 78/191 (40%), Positives = 117/191 (61%), Gaps = 1/191 (0%)
Query: 317 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGS 376
G++++ GG+ +S+ERYDP ++W M+ M R G G+ V ++Y +GG+DG
Sbjct: 378 GDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGL 437
Query: 377 SYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPK 436
+ LNSVE+YDP T W++ V P +T R+ GVA+L +Y VGG DG + L+ VE Y+ +
Sbjct: 438 NILNSVEKYDPHTGHWTN-VTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIR 496
Query: 437 ENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTR 496
+ WT V SM+T R V VL G LYA+ G DG S L+++E Y+P + W + MGT+
Sbjct: 497 TDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQ 556
Query: 497 RKHLGCAVYQD 507
R G V ++
Sbjct: 557 RCDAGVCVLRE 567
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 478 bits (1229), Expect = e-135
Identities = 240/525 (45%), Positives = 351/525 (66%), Gaps = 10/525 (1%)
Query: 83 RVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 142
R++LS+ S YF AMFT ++ E+RQ E+ + ++ ++ LI +AYT ++ ++E N++ LL
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 143 PAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVME 202
ACLLQL+++ EACC+FL +QL PSNCLGIR+FAD C +L ++A +T +F EV+
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 203 SEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLL 262
++EF+LLPA+++ +++SD++N+ +EE + NA++ WV++ +++RR L ++L ++RLPLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 263 SPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFA 322
+P+FL + ++ L + D EC+ L+ EA Y LLP+ RP++Q PRT+PRK LFA
Sbjct: 354 APQFL-ADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRK--STVGTLFA 410
Query: 323 VGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSV 382
VGG S +S+E+YD +TN W VA+M+ RR GV+VLDD LY VGG DG LN+V
Sbjct: 411 VGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTV 470
Query: 383 ERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTR 442
E Y+PKT WS + P ST R +GVAVL G +YAVGG DG S LN VER+DP+ +W
Sbjct: 471 ECYNPKTKTWSV-MPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNF 529
Query: 443 VASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGC 502
VA+MST R V VAVL G LYAVGG DG+S L +VE ++P N+W A M RR +G
Sbjct: 530 VATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGV 589
Query: 503 AVYQDMIYAVGGRDD-----TTELSS-AERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQL 556
+ ++YA+GG D T+ LS ERY+P+T+ W+ V +M+ R VG+ ++ +L
Sbjct: 590 TTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKL 649
Query: 557 MAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKM 601
AVGG+DG YL T+E +DP N W + R G V +K+
Sbjct: 650 YAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 469 bits (1208), Expect = e-132
Identities = 255/554 (46%), Positives = 350/554 (63%), Gaps = 6/554 (1%)
Query: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
H ++ +V+N LR LCDV +V +I AHRV+L+ACSPYF AMFTGE++ESR V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
I+++D + +LID+ YT++I V E NVQ LLPAA LLQL ++++ CCEFL+ QL P N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
CLGIRAFAD H+C +LL A+ + + +F +V+ SEEF+ L Q+ +ISSD+L + SEE
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
+VF AV+AWV + R+ + ++++HVRLPLL ++LV V + L+K+ C+D + E
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 290 AKNYLLLP-QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMV 348
A Y LLP ++R LM+ RTR R P+ +++ VGG + AI SVE YD + W V
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-APKAIRSVECYDFKEERWHQV 340
Query: 349 ASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGV 408
A + RRC G+ + L++AVGG +GS + +V+ YDP +QW+S VA R+++G
Sbjct: 341 AELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTS-VANMRDRRSTLGA 399
Query: 409 AVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGS 468
AVL G LYAVGG DG + L+ VE Y+ K N+W VA M+TRR V V V+GG LYAVGG
Sbjct: 400 AVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGY 459
Query: 469 DGTSP--LNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAER 526
DG S L+TVE YN N W IA M TRR G V +++YAVGG D S E
Sbjct: 460 DGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEV 519
Query: 527 YNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 586
Y+P TN W V M R G+ VNG L VGG DG+ L ++E ++P + W +
Sbjct: 520 YDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSS 579
Query: 587 -MNYRRLGGGVGVI 599
M+ R GV VI
Sbjct: 580 CMSTGRSYAGVTVI 593
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 469 bits (1208), Expect = e-132
Identities = 255/554 (46%), Positives = 350/554 (63%), Gaps = 6/554 (1%)
Query: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
H ++ +V+N LR LCDV +V +I AHRV+L+ACSPYF AMFTGE++ESR V
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
I+++D + +LID+ YT++I V E NVQ LLPAA LLQL ++++ CCEFL+ QL P N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
CLGIRAFAD H+C +LL A+ + + +F +V+ SEEF+ L Q+ +ISSD+L + SEE
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
+VF AV+AWV + R+ + ++++HVRLPLL ++LV V + L+K+ C+D + E
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
Query: 290 AKNYLLLP-QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMV 348
A Y LLP ++R LM+ RTR R P+ +++ VGG + AI SVE YD + W V
Sbjct: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-APKAIRSVECYDFKEERWHQV 336
Query: 349 ASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGV 408
A + RRC G+ + L++AVGG +GS + +V+ YDP +QW+S VA R+++G
Sbjct: 337 AELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTS-VANMRDRRSTLGA 395
Query: 409 AVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGS 468
AVL G LYAVGG DG + L+ VE Y+ K N+W VA M+TRR V V V+GG LYAVGG
Sbjct: 396 AVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGY 455
Query: 469 DGTSP--LNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAER 526
DG S L+TVE YN N W IA M TRR G V +++YAVGG D S E
Sbjct: 456 DGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEV 515
Query: 527 YNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 586
Y+P TN W V M R G+ VNG L VGG DG+ L ++E ++P + W +
Sbjct: 516 YDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSS 575
Query: 587 -MNYRRLGGGVGVI 599
M+ R GV VI
Sbjct: 576 CMSTGRSYAGVTVI 589
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 468 bits (1203), Expect = e-132
Identities = 252/558 (45%), Positives = 352/558 (63%), Gaps = 6/558 (1%)
Query: 46 ISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR 105
++ H + +V+N LR + LCDV++V +I AHRV+L+ACSPYF AMFTG+++ES+
Sbjct: 28 VNPAHMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESK 87
Query: 106 QTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQL 165
++ I+D+D + + LID+ YT++I V E NVQ LLPAA LLQL ++++ CC+FL+ QL
Sbjct: 88 AKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQL 147
Query: 166 DPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNV 225
P+NCLGIRAFAD H+C +LL+ A+ + + +F EVM EEF+ L +Q+ +ISSD+L V
Sbjct: 148 HPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTV 207
Query: 226 RSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRD 285
SEE+VF AV++W+ Y + R + ++++HVRLPLL +LV TV + LIK++ C+D
Sbjct: 208 SSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKD 267
Query: 286 LVDEAKNYLLLP-QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNE 344
+ EA Y LLP +R L++ PRT+PR P+ +V+ VGG + AI SVE YD + +
Sbjct: 268 FLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQ-APKAIRSVECYDFEEDR 326
Query: 345 WRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRT 404
W +A + RRC GV + +YAVGG +GS + +V+ YD +QW+S +A R+
Sbjct: 327 WDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTS-IASMQERRS 385
Query: 405 SVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYA 464
++G AVL LYAVGG DG + L VE Y K N+W VA M+TRR V V V+ G LYA
Sbjct: 386 TLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYA 445
Query: 465 VGGSDGTSP--LNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELS 522
VGG DG S L+TVE+YNP N W +A M TRR G V +YA GG D
Sbjct: 446 VGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRK 505
Query: 523 SAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWR 582
S E Y+P TN W V M R G+ VNG L VGG DG+ L ++E ++P + W
Sbjct: 506 SVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWT 565
Query: 583 LY-GGMNYRRLGGGVGVI 599
L M+ R GV VI
Sbjct: 566 LLPTNMSTGRSYAGVAVI 583
Score = 97.1 bits (240), Expect = 4e-20
Identities = 50/136 (36%), Positives = 76/136 (55%)
Query: 465 VGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSA 524
V G + +VE Y+ +E+RW IA + +RR G +YAVGG + + + +
Sbjct: 305 VVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTV 364
Query: 525 ERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLY 584
+ Y+ +QW+ + +M RRS +G AV+N L AVGGFDG+T L ++E + N W
Sbjct: 365 DVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFV 424
Query: 585 GGMNYRRLGGGVGVIK 600
MN RR GVGV++
Sbjct: 425 APMNTRRSSVGVGVVE 440
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 466 bits (1198), Expect = e-131
Identities = 241/558 (43%), Positives = 351/558 (62%), Gaps = 10/558 (1%)
Query: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
H QTL + K ++LCDV+L+ G +I AHR++LSA S YF AMFT ++ E++Q EV
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
+ +D A+ L+ +AYT + ++E +++LL AACLLQL ++ + C FL +QL PSN
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
CLGIR+F D C ELL +A K+T +F EV++++EF+LLPAN++ ++ SD++NV EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
+F+A+M WV + +Q R+ +L +L ++RLPLL P+ L+ + + + D EC+ L+ E
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLME 402
Query: 290 AKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVA 349
A Y LLP+ R +MQ PRT+PRK L+AVGG + +++E+YD +TN W +
Sbjct: 403 AMKYHLLPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
Query: 350 SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVA 409
+M+ RR GV+V+D+ LY VGG DG LN+VE ++P W+ + P ST R +GVA
Sbjct: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV-MPPMSTHRHGLGVA 519
Query: 410 VLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD 469
L G +YAVGG DG S LN VER+DP+ +W VASMST R V V L LYA+GG D
Sbjct: 520 TLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD 579
Query: 470 GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRD-----DTTELSS- 523
G+S L ++E ++P N+W APM RR +G A Y +Y VGG D + LS
Sbjct: 580 GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDC 639
Query: 524 AERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRL 583
ERY+P+ + WS V ++ R V + + +L VGG+DG TYL T+E +D N W+
Sbjct: 640 VERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
Query: 584 YGGMNYRRLGGGVGVIKM 601
+N R G V V+K+
Sbjct: 700 EVPVNIGRAGACVVVVKL 717
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 460 bits (1183), Expect = e-129
Identities = 243/546 (44%), Positives = 346/546 (63%), Gaps = 9/546 (1%)
Query: 59 NLLR--KHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDE 116
+LLR ++ ELCDV L VG+K I H+++L+ PYFRAMF E+AE++QT + IRD D
Sbjct: 56 SLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDG 115
Query: 117 RAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAF 176
A+E L+ F Y+S++T+ NVQ LL AAC+LQ+ + ACCE++K PSNCL +RAF
Sbjct: 116 DAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAF 175
Query: 177 ADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVM 236
A++H+ +L+ +AD++ +F EV+E E+F+ + L ++SS +LN+ +E+QV+NA +
Sbjct: 176 AESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAI 235
Query: 237 AWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLL 296
W+ + Q L + L VRLPLL FL+G V + ++K + +CRDL+DEA+NY L
Sbjct: 236 KWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLH 295
Query: 297 PQERPLMQ---GPRTRPRKPIRCGEVLFAVGG-WCSGDAISSVERYDPQTNEWRMVASMS 352
R + RT PRK VLF VGG SGD S+E Y N W M+
Sbjct: 296 LSSRAVPDFEYSIRTTPRK--HTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMN 353
Query: 353 KRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLG 412
RR VGV ++ +YAVGGHDG+ +L S+E +DP TN+W A +T R + +A LG
Sbjct: 354 SRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMK-ASMNTKRRGIALASLG 412
Query: 413 GFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS 472
G +YA+GG D +C N VERYD + ++W+ VA M+T R GV L +YAVGG+DG +
Sbjct: 413 GPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMA 472
Query: 473 PLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTN 532
L++VERY+P ++W + MG RR G + +Y VGG DD + LSS ERY+PR+N
Sbjct: 473 SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSN 532
Query: 533 QWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRL 592
+W V A+T+ R GVG+A V G++ AVGG +G YL T+E FDP N W L G +++ R
Sbjct: 533 KWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRA 592
Query: 593 GGGVGV 598
G GV V
Sbjct: 593 GAGVAV 598
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 459 bits (1182), Expect = e-129
Identities = 235/539 (43%), Positives = 342/539 (63%), Gaps = 10/539 (1%)
Query: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
H QTL + K ++LCDV+L+ G +I AHR++LSA S YF AMFT ++ E++Q EV
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
+ +D A+ L+ +AYT + ++E +++LL AACLLQL ++ + C FL +QL PSN
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
CLGIR+F D C ELL +A K+T +F EV++++EF+LLPAN++ ++ SD++NV EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
+F+A+M WV + +Q R+ +L +L ++RLPLL P+ L+ + + + D EC+ L+ E
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLME 402
Query: 290 AKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVA 349
A Y LLP+ R +MQ PRT+PRK L+AVGG + +++E+YD +TN W +
Sbjct: 403 AMKYHLLPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
Query: 350 SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVA 409
+M+ RR GV+V+D+ LY VGG DG LN+VE ++P W+ + P ST R +GVA
Sbjct: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV-MPPMSTHRHGLGVA 519
Query: 410 VLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD 469
L G +YAVGG DG S LN VER+DP+ +W VASMST R V V L LYA+GG D
Sbjct: 520 TLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD 579
Query: 470 GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRD-----DTTELSS- 523
G+S L ++E ++P N+W APM RR +G A Y +Y VGG D + LS
Sbjct: 580 GSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDC 639
Query: 524 AERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWR 582
ERY+P+ + WS V ++ R V + + +L VGG+DG TYL T+E +D N W+
Sbjct: 640 VERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
Score = 165 bits (418), Expect = 1e-40
Identities = 84/186 (45%), Positives = 114/186 (61%), Gaps = 2/186 (1%)
Query: 413 GFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS 472
G LYAVGG D + +E+YD + N W + +M+ RRL VAV+ LY VGG DG
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 473 PLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTN 532
LNTVE +NP W + PM T R LG A + +YAVGG D + L++ ER++P
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGR 548
Query: 533 QWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRL 592
QW+ V +M++ RS VG+ +N +L A+GG DG++ LK++E FDP N W L M+ RR
Sbjct: 549 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRR- 607
Query: 593 GGGVGV 598
GGVGV
Sbjct: 608 -GGVGV 612
Score = 70.1 bits (170), Expect = 6e-12
Identities = 35/92 (38%), Positives = 51/92 (55%)
Query: 509 IYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYL 568
+YAVGG D ++ E+Y+ RTN W + M RR G+AV++ +L VGG DG L
Sbjct: 431 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTL 490
Query: 569 KTIEVFDPDANTWRLYGGMNYRRLGGGVGVIK 600
T+E F+P W + M+ R G GV ++
Sbjct: 491 NTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
Score = 68.2 bits (165), Expect = 2e-11
Identities = 31/62 (50%), Positives = 40/62 (64%)
Query: 335 VERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSS 394
VERYDP+ + W VA +S R V V L D LY VGG+DG +YLN+VE YD + N+W
Sbjct: 640 VERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
Query: 395 DV 396
+
Sbjct: 700 SM 701
Score = 40.8 bits (94), Expect = 0.004
Identities = 23/46 (50%), Positives = 25/46 (54%)
Query: 554 GQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 599
G L AVGG D TIE +D N+W G MN RRL GV VI
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 459 bits (1181), Expect = e-129
Identities = 237/552 (42%), Positives = 341/552 (61%), Gaps = 2/552 (0%)
Query: 51 PRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVV 110
P + V+ +R+ +LCDV L +G K AHR++L+A PYF AMFT ++ E +Q E+V
Sbjct: 21 PSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIV 80
Query: 111 IRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNC 170
++ +D A+E LI+FAY + +++ NVQ+LL A LQL I++ACC FL+ +L P NC
Sbjct: 81 MQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Query: 171 LGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQ 230
LG+R FA+T C L A+ F +F EV SEEF+ LP +++++S DELNV+SEEQ
Sbjct: 141 LGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQ 200
Query: 231 VFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEA 290
VF A +AWV+Y ++R P LP++L ++RLPL P+FL V D L++ +CRDLVDEA
Sbjct: 201 VFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEA 260
Query: 291 KNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCS-GDAISSVERYDPQTNEWRMVA 349
K+Y L+P+ RP + RTRPR +++AVGG S GD+++ VE +DP N W
Sbjct: 261 KDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCR 320
Query: 350 SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVA 409
M+ R VGV+V++ LLYA+GG+DG L++VE Y+P+T+ W+ V ++ R+++G
Sbjct: 321 PMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTR-VGSMNSKRSAMGTV 379
Query: 410 VLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD 469
VL G +Y GG DG S L+ VE Y P+ +KWT V SMS+ R V V G +Y GG D
Sbjct: 380 VLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHD 439
Query: 470 GTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNP 529
G ++VE YN WH A M +R G A ++ GG D + LS AE Y+
Sbjct: 440 GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
Query: 530 RTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNY 589
+QW +V M +RRS V L G+L AVGG+DG + L ++E++DP+ + W M
Sbjct: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPMAC 559
Query: 590 RRLGGGVGVIKM 601
G GVG I +
Sbjct: 560 HEGGVGVGCIPL 571
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 446 bits (1148), Expect = e-125
Identities = 243/561 (43%), Positives = 346/561 (61%), Gaps = 23/561 (4%)
Query: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
H Q L+ +NLLR+H ELCD++L VG KI+AH+V+L++ SPYF+AMFTG L+E +EV
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
+ IDE A++ ++++AYT + + + V++LLPAA LLQ+ + + CC FL+ QLDP N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
C+GI FA+T+ CR+L A K+ NF+ V ++EEF L L +I+S+D LNV +EE
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
VF A+ +W+KY +QER+ L Q+L VRLPLLS KFL ++ LI+ D C+ L++E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 290 AKNYLLLPQER-----PLMQGPRTRPRKPIRCGEVLFAVGGWCSGDA-ISSVERYDPQTN 343
A Y +P+ R LM PR P+ VL AVGG A + SVE Y PQ +
Sbjct: 257 ALKYHFMPEHRLSHQTVLMTRPRCAPK-------VLCAVGGKSGLFACLDSVEMYFPQND 309
Query: 344 EWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGS--------SYLNSVERYDPKTNQWSSD 395
W +A ++ R G+ VLD +Y +GG + + NSVE ++P TN W+S
Sbjct: 310 SWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTS- 368
Query: 396 VAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAV 455
+ + R+++GV VL G LYA+GG DG S L VE+Y PK KW VA M+T R A
Sbjct: 369 LERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAA 428
Query: 456 AVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR 515
AVL G +YA+GG G + +N+VERY+P ++ W +A M +R H G V I+ VGG
Sbjct: 429 AVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGH 487
Query: 516 DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFD 575
+ + LSS ERY+P NQW+ M R+GVG AV++ L VGG G++YL T++ +D
Sbjct: 488 NGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYD 547
Query: 576 PDANTWRLYGGMNYRRLGGGV 596
P ++TW GM Y R G+
Sbjct: 548 PISDTWLDSAGMIYCRCNFGL 568
Score = 36.2 bits (82), Expect = 0.090
Identities = 20/62 (32%), Positives = 30/62 (48%), Gaps = 7/62 (11%)
Query: 309 RPRKPIRCG-------EVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVS 361
RP K R G L+ VGG +++V++YDP ++ W A M RC G++
Sbjct: 510 RPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLT 569
Query: 362 VL 363
L
Sbjct: 570 AL 571
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 412 bits (1060), Expect = e-115
Identities = 227/503 (45%), Positives = 314/503 (62%), Gaps = 6/503 (1%)
Query: 101 LAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEF 160
++ESR V I+++D + +LID+ YT++I V E NVQ LLPAA LLQL ++++ CCEF
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 161 LKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISS 220
L+ QL P NCLGIRAFAD H+C +LL A+ + + +F +V+ SEEF+ L Q+ +ISS
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 221 DELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSD 280
D+L + SEE+VF AV+AWV + R+ + ++++HVRLPLL ++LV V + L+K+
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 281 EECRDLVDEAKNYLLLP-QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYD 339
C+D + EA Y LLP ++R LM+ RTR R P+ +++ VGG + AI SVE YD
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-APKAIRSVECYD 239
Query: 340 PQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPT 399
+ W VA + RRC G+ + L++AVGG +GS + +V+ YDP +QW+S VA
Sbjct: 240 FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTS-VANM 298
Query: 400 STCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLG 459
R+++G AVL G LYAVGG DG + L+ VE Y+ K N+W VA M+TRR V V V+G
Sbjct: 299 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
Query: 460 GFLYAVGGSDGTSP--LNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD 517
G LYAVGG DG S L+TVE YN N W IA M TRR G V +++YAVGG D
Sbjct: 359 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 418
Query: 518 TTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPD 577
S E Y+P TN W V M R G+ VNG L VGG DG+ L ++E ++P
Sbjct: 419 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 478
Query: 578 ANTWRLYGG-MNYRRLGGGVGVI 599
+ W + M+ R GV VI
Sbjct: 479 TDKWTVVSSCMSTGRSYAGVTVI 501
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 393 bits (1010), Expect = e-109
Identities = 226/573 (39%), Positives = 326/573 (56%), Gaps = 18/573 (3%)
Query: 45 YISDKHPRQTLEVINLLRKHRELCDVVLVVG-----AKKIYAHRVILSACSPYFRAMFTG 99
Y + H +Q ++N LR ++LCDV L V A + AH+V+L++ SP F+AMFT
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 100 ELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCE 159
L E V I I + ME LI+FAYT+ I++ E V ++ A + Q+ + AC +
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 160 FLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIIS 219
FL +QLDPSN +GI FA+ C EL + A ++ +F EV + EEF L QL+ +IS
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
Query: 220 SDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKS 279
D+LNVR E +VF+A + WVKY ++RR + +L+ VR L+P FL + +++S
Sbjct: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
Query: 280 DEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYD 339
D C+D + + L L + +M P + + G +++ GG+ ++S +E Y+
Sbjct: 294 DSRCKDYLVKIFEELTLHKPTQVM------PCRAPKVGRLIYTAGGYFR-QSLSYLEAYN 346
Query: 340 PQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGH----DGSSYLNSVERYDPKTNQWSSD 395
P W +A + R G+ V+ LLYAVGG DG++ ++++ Y+P TNQWS
Sbjct: 347 PSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSP- 405
Query: 396 VAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAV 455
AP S R +GV V+ G +YAVGG G N VERY+P+ ++W VA M TRR+GV V
Sbjct: 406 CAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGV 465
Query: 456 AVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR 515
AVL LYAVGG DGT+ LN+ E Y P+ N W I M T R G V + IYA GG
Sbjct: 466 AVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525
Query: 516 DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFD 575
D +L+S ERY+ T W+ V M RRS +G+ V G++ +GG+DG T+L ++E +D
Sbjct: 526 DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYD 585
Query: 576 PDANTWRLYGGMNYRRLGGGVGVIKMTHCESHI 608
PD +TW M R G GV V M C I
Sbjct: 586 PDTDTWSEVTRMTSGRSGVGVAV-TMEPCRKQI 617
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 393 bits (1010), Expect = e-109
Identities = 226/573 (39%), Positives = 326/573 (56%), Gaps = 18/573 (3%)
Query: 45 YISDKHPRQTLEVINLLRKHRELCDVVLVVG-----AKKIYAHRVILSACSPYFRAMFTG 99
Y + H +Q ++N LR ++LCDV L V A + AH+V+L++ SP F+AMFT
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 100 ELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCE 159
L E V I I + ME LI+FAYT+ I++ E V ++ A + Q+ + AC +
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 160 FLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIIS 219
FL +QLDPSN +GI FA+ C EL + A ++ +F EV + EEF L QL+ +IS
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
Query: 220 SDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKS 279
D+LNVR E +VF+A + WVKY ++RR + +L+ VR L+P FL + +++S
Sbjct: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
Query: 280 DEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYD 339
D C+D + + L L + +M P + + G +++ GG+ ++S +E Y+
Sbjct: 294 DSRCKDYLVKIFEELTLHKPTQVM------PCRAPKVGRLIYTAGGYFR-QSLSYLEAYN 346
Query: 340 PQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGH----DGSSYLNSVERYDPKTNQWSSD 395
P W +A + R G+ V+ LLYAVGG DG++ ++++ Y+P TNQWS
Sbjct: 347 PSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSP- 405
Query: 396 VAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAV 455
AP S R +GV V+ G +YAVGG G N VERY+P+ ++W VA M TRR+GV V
Sbjct: 406 CAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGV 465
Query: 456 AVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR 515
AVL LYAVGG DGT+ LN+ E Y P+ N W I M T R G V + IYA GG
Sbjct: 466 AVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525
Query: 516 DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFD 575
D +L+S ERY+ T W+ V M RRS +G+ V G++ +GG+DG T+L ++E +D
Sbjct: 526 DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYD 585
Query: 576 PDANTWRLYGGMNYRRLGGGVGVIKMTHCESHI 608
PD +TW M R G GV V M C I
Sbjct: 586 PDTDTWSEVTRMTSGRSGVGVAV-TMEPCRKQI 617
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 382 bits (982), Expect = e-106
Identities = 221/584 (37%), Positives = 323/584 (55%), Gaps = 22/584 (3%)
Query: 35 EGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFR 94
E P+ A P+ SDKH + L IN +R + CDV L VG + AHR++L+A SPYF
Sbjct: 4 EDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFA 63
Query: 95 AMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQ 154
A+FTG + ES + V I I+ ++L+DF YT + + NVQ L+ AA +LQL E+
Sbjct: 64 ALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVV 123
Query: 155 EACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQL 214
CCEFLK Q+DP NC+GI F++ +C +LL ++ + +F EV EEF+ L +QL
Sbjct: 124 HLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQL 183
Query: 215 IDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSD 274
I I+ S+EL++ E QVF A M W+ + +RR + +VL +R PLL P+ L+ +
Sbjct: 184 IKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGV 243
Query: 275 PLIKSDEECRDLVDEAKNYLLLPQER---PLMQGPRTRPRKPIRCGEVLFAVGG------ 325
+ L+ E P+E +Q + RPRK R + L+AVGG
Sbjct: 244 SDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKAR--KYLYAVGGYTRLQG 301
Query: 326 --WCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVE 383
W A+S VER+D + W V+S+ + R G+GV+VL ++YA+GG S + E
Sbjct: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
Query: 384 RYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRV 443
YDP T QW++ VA + R +GV V G +YA+GG G N +ER+DP ENKW V
Sbjct: 362 CYDPVTKQWTT-VASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
Query: 444 ASMSTRRLGVAVAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGC 502
+M+ R + G +Y +GG S+ L + E Y+P RW + PMGTRR +LG
Sbjct: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
Query: 503 AVYQDMIYAVGGRDDTTE-LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGG 561
A D IY+VGG ++T + L + E+Y+ +W V +M R+G+ + VNG L GG
Sbjct: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Query: 562 ------FDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 599
F L ++EV++P ++TW G M R GGV V+
Sbjct: 541 RSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 369 bits (948), Expect = e-102
Identities = 205/544 (37%), Positives = 292/544 (53%), Gaps = 10/544 (1%)
Query: 44 PYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAE 103
P++ K E+ N LR +LCDVV+ V + AH+ IL +CS YFRA+FT
Sbjct: 15 PHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNN 74
Query: 104 SRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKR 163
+ + I I M+L+I++AYT + + NV+ LL AA + I CCEFLK
Sbjct: 75 TEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKS 134
Query: 164 QLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVME-SEEFMLLPANQLIDIISSDE 222
+L NC+GI F D + C EL + A F HNF+E+++ S EF+ L +L DII DE
Sbjct: 135 ELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDE 194
Query: 223 LNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEE 282
LNV+ E+ VF A++ W+ + Q R+ + +L VRL L+ ++ + V + +K EE
Sbjct: 195 LNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEE 254
Query: 283 CRDLVDEAKNYLL-LPQERPL---MQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERY 338
C+ ++ A + L P P TRPR P +LFA+GGW G +++E Y
Sbjct: 255 CKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYA---ILFAIGGWSGGSPTNAIEAY 311
Query: 339 DPQTNEW-RMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVA 397
D + + W + R G + L +Y +GG D Y NSV+R+DP W VA
Sbjct: 312 DARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQ-VA 370
Query: 398 PTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAV 457
P + R V V VLG F+YA+GG DG LN ERY+P+ N+WT +A M +R +
Sbjct: 371 PMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATT 430
Query: 458 LGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD 517
L G +Y GG +G L T E YN + N+W IAPM +RR +G Y + +YAVGG D
Sbjct: 431 LYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDG 490
Query: 518 TTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPD 577
L SAE Y+P N W + M + RS G+ VV+ L VGGF+G T +E +D
Sbjct: 491 ANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEK 550
Query: 578 ANTW 581
+ W
Sbjct: 551 TDEW 554
Score = 31.2 bits (69), Expect = 2.9
Identities = 17/49 (34%), Positives = 25/49 (51%)
Query: 318 EVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDL 366
++LF VGG+ +VE YD +T+EW MS R + V+ L
Sbjct: 527 DLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGL 575
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 364 bits (934), Expect = e-100
Identities = 207/540 (38%), Positives = 302/540 (55%), Gaps = 16/540 (2%)
Query: 35 EGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFR 94
E P+ A P+ SDKH + L IN +R + CDV L VG + AHR++L+A SPYF
Sbjct: 4 EDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFA 63
Query: 95 AMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQ 154
A+FTG + ES + V I I+ ++L+DF YT + + NVQ L+ AA +LQL E+
Sbjct: 64 ALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVV 123
Query: 155 EACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQL 214
CCEFLK Q+DP NC+GI F++ +C +LL ++ + +F EV EEF+ L +QL
Sbjct: 124 HLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQL 183
Query: 215 IDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSD 274
I I+ S+EL++ E QVF A M W+ + +RR + +VL +R PLL P+ L+ +
Sbjct: 184 IKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGV 243
Query: 275 PLIKSDEECRDLVDEAKNYLLLPQER---PLMQGPRTRPRKPIRCGEVLFAVGG------ 325
+ L+ E P+E +Q + RPRK R + L+AVGG
Sbjct: 244 SDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKAR--KYLYAVGGYTRLQG 301
Query: 326 --WCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVE 383
W A+S VER+D + W V+S+ + R G+GV+VL ++YA+GG S + E
Sbjct: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
Query: 384 RYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRV 443
YDP T QW++ VA + R +GV V G +YA+GG G N +ER+DP ENKW V
Sbjct: 362 CYDPVTKQWTT-VASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
Query: 444 ASMSTRRLGVAVAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGC 502
+M+ R + G +Y +GG S+ L + E Y+P RW + PMGTRR +LG
Sbjct: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
Query: 503 AVYQDMIYAVGGRDDTTE-LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGG 561
A D IY+VGG ++T + L + E+Y+ +W V +M R+G+ + VNG L GG
Sbjct: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Score = 96.7 bits (239), Expect = 6e-20
Identities = 60/166 (36%), Positives = 81/166 (48%), Gaps = 13/166 (7%)
Query: 435 PKENKWTRVASMSTRRLGVAVAVLGGFLYAVGG---------SDGTSPLNTVERYNPQEN 485
PKENK+ S R +LYAVGG SD + L+ VER++
Sbjct: 266 PKENKFCSFLQTSKVRPRKKARK---YLYAVGGYTRLQGGRWSDSRA-LSCVERFDTFSQ 321
Query: 486 RWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRS 545
W T++ + R LG V M+YA+GG D+ E Y+P T QW+ V +M R
Sbjct: 322 YWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRC 381
Query: 546 GVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRR 591
G+G+ V G + A+GG+ G TIE FDPD N W + G M R
Sbjct: 382 GLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSR 427
Score = 59.7 bits (143), Expect = 8e-09
Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 11/126 (8%)
Query: 481 NPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR--------DDTTELSSAERYNPRTN 532
+P+EN++ + R Y +YAVGG D+ LS ER++ +
Sbjct: 265 SPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQ 321
Query: 533 QWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRL 592
W+ V ++ RSG+G+ V+ G + A+GG + E +DP W MN+ R
Sbjct: 322 YWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRC 381
Query: 593 GGGVGV 598
G GV V
Sbjct: 382 GLGVCV 387
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/60 (38%), Positives = 36/60 (60%), Gaps = 1/60 (1%)
Query: 318 EVLFAVGGWC-SGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGS 376
+ +++VGGW + DA+ +VE+Y + +W VASM R G+ V ++ LLY GG S
Sbjct: 485 DCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 314 bits (805), Expect = 1e-85
Identities = 196/532 (36%), Positives = 279/532 (52%), Gaps = 17/532 (3%)
Query: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
H L++ N R R DV++ V K+ HR +LSACS YFRAMF + ESR+ V
Sbjct: 48 HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLV 107
Query: 110 VIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSN 169
I I AME + + YT ++ + NVQ L + L Q++ +++AC +FL+ QLDP N
Sbjct: 108 EINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCN 167
Query: 170 CLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEE 229
CLGI+ FADTHS + L F F++V + EEF+ L ++LID I SDEL + EE
Sbjct: 168 CLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227
Query: 230 QVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDE 289
VF AVM WV ++ RRP L ++L HVRLPLL P + V TV D LI++ EC L+ E
Sbjct: 228 MVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHE 287
Query: 290 AKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGW--CSGDAISSVERYDPQTNEWRM 347
A+ Y +L E M PRTRPR+ EV+ VGG G + E YDP T EW+
Sbjct: 288 ARRYHILGNE---MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKS 344
Query: 348 VASMSK-RRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSV 406
+A + + + V L + + GG S V Y+ + N W VA + R
Sbjct: 345 LAKLPEFTKSEYAVCALRNDILVSGGRINS---RDVWIYNSQLNIWIR-VASLNKGRWRH 400
Query: 407 GVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVG 466
+AVL G +Y VGG DG + L+ VE YD N+WT VA + AV G L+ +G
Sbjct: 401 KMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIG 460
Query: 467 GS-DGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAE 525
G D + + V+ Y+P+ N W A + ++ + ++IY GG +
Sbjct: 461 GGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL-----TKAIY 515
Query: 526 RYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGG-FDGTTYLKTIEVFDP 576
Y+P + W V SR+ G++V NG++ +GG + TI +DP
Sbjct: 516 CYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDP 567
Score = 73.6 bits (179), Expect = 5e-13
Identities = 60/209 (28%), Positives = 90/209 (43%), Gaps = 13/209 (6%)
Query: 379 LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNI--VERYDPK 436
L+ RY N+ S P + R S G + + + VGG + V N+ E YDP
Sbjct: 285 LHEARRYHILGNEMMS---PRTRPRRSTGYSEV---IVVVGGCERVGGFNLPYTECYDPV 338
Query: 437 ENKWTRVASMST-RRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGT 495
+W +A + + AV L + GG + V YN Q N W +A +
Sbjct: 339 TGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS---RDVWIYNSQLNIWIRVASLNK 395
Query: 496 RRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQ 555
R AV +Y VGG D LSS E Y+ +N+W+ V + S + G+
Sbjct: 396 GRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGK 455
Query: 556 LMAVGGF-DGTTYLKTIEVFDPDANTWRL 583
L +GG D T ++ +DP+ N+W L
Sbjct: 456 LFVIGGGPDDNTCSDKVQSYDPETNSWLL 484
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 299 bits (766), Expect = 4e-81
Identities = 183/535 (34%), Positives = 285/535 (53%), Gaps = 22/535 (4%)
Query: 57 VINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDE 116
V+N +RK + LCDV+L+V +KI AHRV+L+A S +F MFT + ES+ EV ++D +
Sbjct: 33 VMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEP 92
Query: 117 RAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAF 176
+E L++FAYT++I+V NVQ+LL AA Q+ +++ C +FLK Q+D SNCLGI
Sbjct: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
Query: 177 ADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVM 236
A+ C EL AD F +F EV +++EF+ L ++ +++ D L VR+E+QV++A +
Sbjct: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
Query: 237 AWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNY-LL 295
W+KY R+P + +L VR PL+S FL TV ++PLI+ + EC +V Y LL
Sbjct: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLL 272
Query: 296 LPQER-PLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKR 354
P++R L+ G R R +K + A+ G G S ++P+ W + ++
Sbjct: 273 SPEDREELVDGTRPRRKK----HDYRIALFG---GSQPQSCRYFNPKDYSWTDIRCPFEK 325
Query: 355 RCGVGVSVLDDLLYAVGGHDGSSYLNSVER---YDPKTNQWSSDVAPTSTCRTSVGVAVL 411
R D+++Y +GG S L ++R Y+ + W S + P T R S+
Sbjct: 326 RRDAACVFWDNVVYILGG----SQLFPIKRMDCYNVVKDSWYSKLGP-PTPRDSLAACAA 380
Query: 412 GGFLYAVGGQD-GVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDG 470
G +Y GG + G S L + E YD + W SM T+R + G +Y GGS G
Sbjct: 381 EGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLG 440
Query: 471 TS----PLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAER 526
+ LN+ E Y+P W + PM RK+ G +D I+AVGG++ L + E
Sbjct: 441 NNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEY 500
Query: 527 YNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 581
Y+ + N+W V M + V A V + + GF G L I ++ + + W
Sbjct: 501 YDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
Score = 68.6 bits (166), Expect = 2e-11
Identities = 50/187 (26%), Positives = 77/187 (41%), Gaps = 10/187 (5%)
Query: 419 GGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVE 478
GG SC ++PK+ WT + +R A +Y +GGS P+ ++
Sbjct: 299 GGSQPQSC----RYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMD 353
Query: 479 RYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRD-DTTELSSAERYNPRTNQWSPV 537
YN ++ W++ T R L + IY GG + + L E Y+ RT W
Sbjct: 354 CYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTK 413
Query: 538 VAMTSRRSGVGLAVVNGQLMAVGGFDGTTY----LKTIEVFDPDANTWRLYGGMNYRRLG 593
+M ++R G+ NG + GG G L + EV+DP TW M R
Sbjct: 414 PSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKN 473
Query: 594 GGVGVIK 600
G+ +K
Sbjct: 474 HGLVFVK 480
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 291 bits (746), Expect = 9e-79
Identities = 179/527 (33%), Positives = 279/527 (52%), Gaps = 22/527 (4%)
Query: 65 RELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLID 124
+ LCDV+L+V +KI AHRV+L+A S +F MFT + ES+ EV ++D + +E L++
Sbjct: 19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVE 78
Query: 125 FAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRE 184
FAYT++I+V NVQ+LL AA Q+ +++ C +FLK Q+D SNCLGI A+ C E
Sbjct: 79 FAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPE 138
Query: 185 LLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQ 244
L AD F +F EV +++EF+ L ++ +++ D L VR+E+QV++A + W+KY
Sbjct: 139 LKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEP 198
Query: 245 ERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNY-LLLPQER-PL 302
R+P + +L VR PL+S FL TV ++PLI+ + EC +V Y LL P++R L
Sbjct: 199 NRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREEL 258
Query: 303 MQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSV 362
+ G R R +K + A+ G G S ++P+ W + ++R
Sbjct: 259 VDGTRPRRKK----HDYRIALFG---GSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVF 311
Query: 363 LDDLLYAVGGHDGSSYLNSVER---YDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVG 419
D+++Y +GG S L ++R Y+ + W S + P T R S+ G +Y G
Sbjct: 312 WDNVVYILGG----SQLFPIKRMDCYNVVKDSWYSKLGP-PTPRDSLAACAAEGKIYTSG 366
Query: 420 GQD-GVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS----PL 474
G + G S L + E YD + W SM T+R + G +Y GGS G + L
Sbjct: 367 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 426
Query: 475 NTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQW 534
N+ E Y+P W + PM RK+ G +D I+AVGG++ L + E Y+ + N+W
Sbjct: 427 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEW 486
Query: 535 SPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 581
V M + V A V + + GF G L I ++ + + W
Sbjct: 487 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
Score = 68.6 bits (166), Expect = 2e-11
Identities = 50/187 (26%), Positives = 77/187 (41%), Gaps = 10/187 (5%)
Query: 419 GGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVE 478
GG SC ++PK+ WT + +R A +Y +GGS P+ ++
Sbjct: 277 GGSQPQSC----RYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMD 331
Query: 479 RYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRD-DTTELSSAERYNPRTNQWSPV 537
YN ++ W++ T R L + IY GG + + L E Y+ RT W
Sbjct: 332 CYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTK 391
Query: 538 VAMTSRRSGVGLAVVNGQLMAVGGFDGTTY----LKTIEVFDPDANTWRLYGGMNYRRLG 593
+M ++R G+ NG + GG G L + EV+DP TW M R
Sbjct: 392 PSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKN 451
Query: 594 GGVGVIK 600
G+ +K
Sbjct: 452 HGLVFVK 458
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 286 bits (731), Expect = 5e-77
Identities = 188/547 (34%), Positives = 277/547 (50%), Gaps = 24/547 (4%)
Query: 50 HPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEV 109
HP L +N LRKH DV L G + HR +L+A S YF AMF+ L ESR V
Sbjct: 28 HPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTV 87
Query: 110 VIRD-IDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPS 168
+D + +ELL+DFAY+S+I + E N ++LL A +LQ ++++A EFL++ L PS
Sbjct: 88 NFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPS 147
Query: 169 NCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSE 228
NCLG+ +D H CR L + + +F+ V +SE+F L + L+D+ISSDEL E
Sbjct: 148 NCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDE 207
Query: 229 EQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVD 288
VF A++ WVK+ ++ R+ LP++L+ VRL LL L V S+ L+ +DE + ++D
Sbjct: 208 RVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMD 267
Query: 289 EA---KNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEW 345
EA K +L Q ++ P RPRK G L +GG + + D + E
Sbjct: 268 EALRCKTRIL--QNDGVVTSPCARPRK---AGHTLLILGG--QTFMCDKIYQVDHKAKEI 320
Query: 346 RMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLN-SVERYDPKTNQWSSDVAPTSTCRT 404
A + R S + +Y GG + ++ V YD +WS AP R
Sbjct: 321 IPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSK-AAPMLIARF 379
Query: 405 SVGVAVLGGFLYAVGGQDGVS---------CLNIVERYDPKENKWTRVASMSTRRLGVAV 455
G A L LY VGG ++ L VE+YDP NKW VA + AV
Sbjct: 380 GHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439
Query: 456 AVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGG 514
L+ GG S ++ V+ Y+P ENRW A ++ AV I+ +GG
Sbjct: 440 VSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG 499
Query: 515 RDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVF 574
+ T +SA R++ TNQW+ + MT++R +L VGG+ GT KT++ +
Sbjct: 500 DTEFT-AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCY 558
Query: 575 DPDANTW 581
DP ++TW
Sbjct: 559 DPTSDTW 565
Score = 39.3 bits (90), Expect = 0.011
Identities = 28/103 (27%), Positives = 40/103 (38%), Gaps = 10/103 (9%)
Query: 491 APMGTRRKHLGCAVYQDMIYAVGGRDDTTELSS-AERYNPRTNQWSPVVAMTSRRSGVGL 549
A + + RK + +Y GGR +S Y+ +WS M R G G
Sbjct: 324 ADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGS 383
Query: 550 AVVNGQLMAVGGFDG---------TTYLKTIEVFDPDANTWRL 583
A + L VGG + LK +E +DP AN W +
Sbjct: 384 AELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMM 426
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 283 bits (725), Expect = 2e-76
Identities = 174/554 (31%), Positives = 296/554 (53%), Gaps = 23/554 (4%)
Query: 45 YISDKHPRQTLEVINLLRKHRELCDVVLVVG-AKKIY-AHRVILSACSPYFRAMFTGELA 102
+ S+ H L+ + LR LCDV LV G +I+ HR ++++ S YF+AMFTG +
Sbjct: 27 FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMK 86
Query: 103 ESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 162
E + + +++ ++ +IDF YT+++++ N+Q L AA LQ+ + + C FL
Sbjct: 87 EQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 146
Query: 163 RQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDE 222
+ NC+ + A+T++ E+ + + F NF ++ + EF+ LP +L ++SS+
Sbjct: 147 SGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNS 206
Query: 223 LNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEE 282
L +E ++F A W++ R ++++++R PL++P+ L+ V + +++D
Sbjct: 207 LKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNT 265
Query: 283 CRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVE--RYDP 340
C +L+ EA NY ++P +P+MQ RT R L +GG + S E YD
Sbjct: 266 CVNLLLEASNYQMMPYMQPVMQSDRTAIRSD---STHLVTLGGVLRQQLVVSKELRMYDE 322
Query: 341 QTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD-----GSSYLNSVERYDPKTNQWSSD 395
+ EWR +A M R G++V+ + LY VGG G + +++V R+DP+ N+W
Sbjct: 323 RAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW-MQ 381
Query: 396 VAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAV 455
VA + RT ++ L G LYAVGG+ L VE Y+P+ N+W+ VA MS G A
Sbjct: 382 VASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAG 441
Query: 456 AVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGT-RRKHLGCAVYQDMIYAVGG 514
V GG +Y GG + N + ++P ++W APM T R H C V D +Y +GG
Sbjct: 442 TVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTV-GDKLYVIGG 500
Query: 515 R-----DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGF--DGTTY 567
D ++ S E Y+P +QW+P+ AM +S VG+AV ++ VGG+ +
Sbjct: 501 NHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCM 560
Query: 568 LKTIEVFDPDANTW 581
++ ++ +DP+ + W
Sbjct: 561 VEIVQKYDPEKDEW 574
Score = 99.0 bits (245), Expect = 1e-20
Identities = 59/182 (32%), Positives = 95/182 (52%), Gaps = 16/182 (8%)
Query: 320 LFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYL 379
L+AVGG + +++VE Y+P+ NEW VA MS+ G +V L+Y GG ++
Sbjct: 401 LYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQ 460
Query: 380 NSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQ---------DGVSCLNIV 430
N + +DP T++W AP +T R + +G LY +GG D +SC
Sbjct: 461 NELMCFDPDTDKWMQK-APMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSC---- 515
Query: 431 ERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP--LNTVERYNPQENRWH 488
E Y P ++WT +A+M + V VAV +Y VGG + + V++Y+P+++ WH
Sbjct: 516 EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWH 575
Query: 489 TI 490
+
Sbjct: 576 KV 577
Score = 71.2 bits (173), Expect = 3e-12
Identities = 40/137 (29%), Positives = 66/137 (48%), Gaps = 22/137 (16%)
Query: 480 YNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD-----TTELSSAERYNPRTNQW 534
Y+ + W ++APM R G AV + +Y VGG+ + T + + R++PR N+W
Sbjct: 320 YDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 379
Query: 535 SPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW------------- 581
V ++ +R+ L+ + G L AVGG L T+E ++P N W
Sbjct: 380 MQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGH 439
Query: 582 --RLYGGMNYRRLGGGV 596
+YGG+ Y + GG+
Sbjct: 440 AGTVYGGLMY--ISGGI 454
Score = 29.6 bits (65), Expect = 8.4
Identities = 13/46 (28%), Positives = 24/46 (52%), Gaps = 2/46 (4%)
Query: 320 LFAVGG--WCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVL 363
++ VGG W + + V++YDP+ +EW V + + G+ L
Sbjct: 547 IYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTL 592
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 283 bits (723), Expect = 4e-76
Identities = 176/572 (30%), Positives = 302/572 (52%), Gaps = 24/572 (4%)
Query: 27 LGDPNKLPEGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKK--IYAHRV 84
+G + L P R+ + S+ H L+ + LR LCDV L+ G HRV
Sbjct: 52 MGLSSHLQSSKAGPTRI-FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRV 110
Query: 85 ILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPA 144
++++ S YF+AMFTG + E + + + + + +IDF YT+++++ N+Q L A
Sbjct: 111 MMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEA 170
Query: 145 ACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESE 204
A LQ+ + + C FL + NC+ + A+T++ E+ + + F NF ++ +
Sbjct: 171 ASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTG 230
Query: 205 EFMLLPANQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSP 264
EF+ LP +L ++SS+ L +E ++F A W++ + R ++++++R PL++P
Sbjct: 231 EFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTP 289
Query: 265 KFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVG 324
+ L+ V + +++D C +L+ EA NY ++P +P+MQ RT R L +G
Sbjct: 290 QELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDT---THLVTLG 346
Query: 325 GWCSGDAISSVE--RYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD-----GSS 377
G + S E YD + +EW+ +A M R G++V+ + LY VGG G +
Sbjct: 347 GVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKT 406
Query: 378 YLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKE 437
+++V R+DP+ N+W VA + RT ++ L G+LYAVGG++ L VE Y+P+
Sbjct: 407 AVDTVFRFDPRYNKW-MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRT 465
Query: 438 NKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGT-R 496
N+WT VA MS G A V GG +Y GG + + ++P ++W APM T R
Sbjct: 466 NEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVR 525
Query: 497 RKHLGCAVYQDMIYAVGGR-----DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAV 551
H C V + +Y +GG D ++ S E Y+P +QW+P+ AM +S VG+AV
Sbjct: 526 GLHCMCTV-GERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAV 584
Query: 552 VNGQLMAVGGF--DGTTYLKTIEVFDPDANTW 581
++ VGG+ + ++ ++ +DPD + W
Sbjct: 585 FENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616
Score = 71.2 bits (173), Expect = 3e-12
Identities = 40/137 (29%), Positives = 68/137 (49%), Gaps = 22/137 (16%)
Query: 480 YNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD-----TTELSSAERYNPRTNQW 534
Y+ + + W ++APM R G AV + +Y VGG+ + T + + R++PR N+W
Sbjct: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Query: 535 SPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW------------- 581
V ++ +R+ L+ + G L AVGG + L T+E ++P N W
Sbjct: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
Query: 582 --RLYGGMNYRRLGGGV 596
+YGG+ Y + GG+
Sbjct: 482 AGTVYGGVMY--ISGGI 496
Score = 62.8 bits (151), Expect = 9e-10
Identities = 48/195 (24%), Positives = 79/195 (40%), Gaps = 53/195 (27%)
Query: 320 LFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYL 379
L+AVGG + + +VE Y+P+TNEW VA MS+ G +V ++Y GG ++
Sbjct: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQ 502
Query: 380 NSVERYDPKTNQW--------------------------------SSDVAPTSTC----- 402
+ +DP T++W +SD +C
Sbjct: 503 KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSP 562
Query: 403 --------------RTSVGVAVLGGFLYAVGGQ--DGVSCLNIVERYDPKENKWTRVASM 446
++ VGVAV +Y VGG + + IV++YDP +++W +V +
Sbjct: 563 ILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDL 622
Query: 447 STRRLGVAVAVLGGF 461
G+ L F
Sbjct: 623 PESLGGIRACTLTVF 637
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 282 bits (721), Expect = 7e-76
Identities = 181/535 (33%), Positives = 268/535 (50%), Gaps = 27/535 (5%)
Query: 58 INLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDER 117
+ LR L DV+L V ++ HRV+L+A S YFRAMF +L E + ++I+ +D
Sbjct: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
Query: 118 AMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFA 177
M L+D+ YTS+ + + NVQ +L AA L Q + +AC FL L+P NC+GI A
Sbjct: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
Query: 178 DTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMA 237
DTHS L + + NF +++ SEEF+ LP + L I+ SD+L V E QVF VM+
Sbjct: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
Query: 238 WVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLP 297
WV++ ER LP VL++VRLPLL P + V TV +DPLI+ E L+ EA+ Y L
Sbjct: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHLSG 301
Query: 298 QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDA--ISSVERYDPQTNEWRMVA------ 349
E + RT+PR EV +GG C+ D ++ V DP VA
Sbjct: 302 NE---IISERTKPRMHEFQSEVFMIIGG-CTKDERFVAEVTCLDPLRRSRLEVAKLPLTE 357
Query: 350 ----SMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTS 405
S +K+ L + +Y GG + + V +Y+ N+W + + R
Sbjct: 358 HELESENKKWVEFACVTLKNEVYISGGKETQ---HDVWKYNSSINKW-IQIEYLNIGRWR 413
Query: 406 VGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAV 465
+ VLGG +Y +GG DG+ +N VE YDP N W+ A + A LY +
Sbjct: 414 HKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVI 473
Query: 466 GGS-DGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSA 524
GG +G + + Y+P N+W A M K + ++D IY VGG + +
Sbjct: 474 GGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGG-----AMRAL 528
Query: 525 ERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFD-GTTYLKTIEVFDPDA 578
Y+P + W V ++ R+ G+A N +L GG D + T+ +DP+A
Sbjct: 529 YAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEA 583
Score = 50.1 bits (118), Expect = 6e-06
Identities = 31/121 (25%), Positives = 47/121 (38%), Gaps = 1/121 (0%)
Query: 468 SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERY 527
S G + V +YN N+W I + R V +Y +GG D +++ E Y
Sbjct: 382 SGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETY 441
Query: 528 NPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGF-DGTTYLKTIEVFDPDANTWRLYGG 586
+P N WS + S +L +GG +G + +DP N W L
Sbjct: 442 DPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAA 501
Query: 587 M 587
M
Sbjct: 502 M 502
Score = 48.1 bits (113), Expect = 2e-05
Identities = 22/94 (23%), Positives = 43/94 (45%), Gaps = 3/94 (3%)
Query: 488 HTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGV 547
H + + C ++ +Y GG++ ++ +YN N+W + + R
Sbjct: 358 HELESENKKWVEFACVTLKNEVYISGGKETQHDVW---KYNSSINKWIQIEYLNIGRWRH 414
Query: 548 GLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 581
+ V+ G++ +GGFDG + +E +DP N W
Sbjct: 415 KMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCW 448
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 274 bits (701), Expect = 2e-73
Identities = 183/560 (32%), Positives = 275/560 (49%), Gaps = 31/560 (5%)
Query: 38 PQP-ARMPYISDKHPRQTLEVINLLRKHRELCDVVL-VVGAKKIYAHRVILSACSPYFRA 95
P P A +P+ H L ++ LR R+ DV L G + AHR +L+A SPYFRA
Sbjct: 4 PAPLAVLPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRA 63
Query: 96 MFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQE 155
MF G+L ESR V + + ++LL+DF+YT ++ V N + LL AA LLQ ++E
Sbjct: 64 MFAGQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKE 123
Query: 156 ACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLI 215
AC FL++QLD +NCL ++ FA+ SC L A +F + E + +E+ LP +L+
Sbjct: 124 ACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGE-LGAEQLERLPLARLL 182
Query: 216 DIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDP 275
+ D L V EE + + WV+ R PQ+L+ VRLP + +L+ V ++P
Sbjct: 183 RYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEP 242
Query: 276 LIKSDEECRDLVDEAKNYLLLPQER-PLMQGPRTRPRKPIRCGEVLFAVGGWCSGDA--I 332
L+ C L+ EA+++ +R PR RPR E+L VGG C D +
Sbjct: 243 LVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGG-CDQDCDEL 301
Query: 333 SSVERYDPQTNEWRMVASMSKR-RCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQ 391
+V+ Y+PQT +WR +A G + L + +Y GG DGS + V RY+ N+
Sbjct: 302 VTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNE 361
Query: 392 WSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRL 451
W ++VAP R +VL G LY V ERYD + W + M+
Sbjct: 362 W-AEVAPMLKAREYHSSSVLDGLLYVVAADS-------TERYDHTTDSWEALQPMTYPMD 413
Query: 452 GVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTI-----APMGTRRKHLGCAVYQ 506
+ G LYA+G G + ++ Y+P + W + P K A
Sbjct: 414 NCSTTACRGRLYAIGSLAGKETM-VMQCYDPDTDLWSLVDCGQLPPWSFAPK---TATLN 469
Query: 507 DMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTT 566
++Y V RDD+ E+ + YNP N+W + +M G LAV+ G+L GG+D T
Sbjct: 470 GLMYFV--RDDSAEV---DVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTF 524
Query: 567 YLK-TIEVFDPDANTWRLYG 585
L +E +DP+ W + G
Sbjct: 525 ELSDVVEAYDPETRAWSVVG 544
Score = 72.4 bits (176), Expect = 1e-12
Identities = 63/248 (25%), Positives = 94/248 (37%), Gaps = 57/248 (22%)
Query: 398 PTSTCRTSVGVAVLGGFLYAVGGQDGVSC--LNIVERYDPKENKWTRVASMSTRRLG-VA 454
P R S G+A + L VGG D C L V+ Y+P+ +W +A G +
Sbjct: 274 PRMRPRPSTGLAEI---LVLVGGCDQ-DCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYS 329
Query: 455 VAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGG 514
+ LG +Y GGSDG+ + V RYN N W +APM R++ +V ++Y V
Sbjct: 330 IVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYVVAA 389
Query: 515 RDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYL------ 568
S ERY+ T+ W + MT G+L A+G G +
Sbjct: 390 -------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYD 442
Query: 569 ---------------------KT----------------IEVFDPDANTWRLYGGMNYRR 591
KT ++V++P N W MN
Sbjct: 443 PDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVH 502
Query: 592 LGGGVGVI 599
+GG + V+
Sbjct: 503 VGGSLAVL 510
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/134 (29%), Positives = 63/134 (47%), Gaps = 10/134 (7%)
Query: 316 CGEVLFAVGGWCSGDAISSVERYDPQTNEWRMV--ASMSKRRCGVGVSVLDDLLYAVGGH 373
C L+A+G +G ++ YDP T+ W +V + + L+ L+Y V
Sbjct: 420 CRGRLYAIGS-LAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--R 476
Query: 374 DGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLN-IVER 432
D S+ V+ Y+P N+W + + +AVLGG LY GG D L+ +VE
Sbjct: 477 DDSA---EVDVYNPTRNEWDK-IPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEA 532
Query: 433 YDPKENKWTRVASM 446
YDP+ W+ V +
Sbjct: 533 YDPETRAWSVVGRL 546
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 273 bits (697), Expect = 4e-73
Identities = 177/554 (31%), Positives = 274/554 (49%), Gaps = 22/554 (3%)
Query: 45 YISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAES 104
+ + H L+ + LR +L DVVL + + AH+V+L+ACS YFRAMFTG + E+
Sbjct: 40 FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
Query: 105 RQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQ 164
Q + ++ + R + +IDFAY++++T++ VQ +L AA LQ+ + E C EFLK
Sbjct: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
Query: 165 LDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELN 224
+ CL I A T S L D FT +F ++ E E+F+ LP +L+ + S+ L
Sbjct: 160 MSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQ 219
Query: 225 VRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECR 284
+E +F A + W+++ RRP+ VL H+R PL+ LV +V + ++ D CR
Sbjct: 220 SCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCR 278
Query: 285 DLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSV-----ERYD 339
+ EA NY +LP + MQ PRT R + L GG D+ SV + +
Sbjct: 279 QYLLEAFNYQVLPFRQHEMQSPRTAVRSDV---PSLVTFGGTPYTDSDRSVSSKVYQLPE 335
Query: 340 PQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGG-----HDGSSYLNSVERYDPKTNQWSS 394
P +R + M V+VLD+ +Y GG G +++ RYDP N+W
Sbjct: 336 PGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLR 395
Query: 395 DVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVA 454
+ R + VL G +YA GG++ L VERY P+ N+W S+ R G A
Sbjct: 396 -LQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHA 454
Query: 455 VAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVG 513
A GG LY GG + Y+P ++W APM R IYA+G
Sbjct: 455 GAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALG 514
Query: 514 GR----DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLK 569
GR D ++ + E Y P T+QW+ V M + +S G ++ ++ VGG++
Sbjct: 515 GRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNV 574
Query: 570 T--IEVFDPDANTW 581
T ++V++ D + W
Sbjct: 575 TGIVQVYNTDTDEW 588
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,905,563
Number of Sequences: 37866
Number of extensions: 1104252
Number of successful extensions: 3908
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 2378
Number of HSP's gapped (non-prelim): 419
length of query: 609
length of database: 18,247,518
effective HSP length: 108
effective length of query: 501
effective length of database: 14,157,990
effective search space: 7093152990
effective search space used: 7093152990
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.