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Search of human proteins with 40786394
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40786394 fumarylacetoacetate hydrolase domain containing 2B
[Homo sapiens]
(314 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40786394 fumarylacetoacetate hydrolase domain containing 2B [... 644 0.0
gi|156231349 fumarylacetoacetate hydrolase domain containing 2A ... 625 e-179
gi|13654274 fumarylacetoacetate hydrolase domain containing 1 is... 144 1e-34
gi|215422413 fumarylacetoacetate hydrolase domain containing 1 i... 144 1e-34
gi|66348062 fumarylacetoacetate hydrolase domain containing 1 is... 144 1e-34
gi|170784824 paired box 4 [Homo sapiens] 33 0.33
gi|48762700 GTF2I repeat domain containing 2 [Homo sapiens] 30 3.6
gi|51241788 GTF2I repeat domain containing 2B [Homo sapiens] 30 3.6
gi|223646109 family with sequence similarity 157, member A [Homo... 28 8.1
gi|239743047 PREDICTED: similar to family with sequence similari... 28 8.1
gi|7705387 GTF2I repeat domain containing 1 isoform 1 [Homo sapi... 28 8.1
gi|15011924 GTF2I repeat domain containing 1 isoform 2 [Homo sap... 28 8.1
gi|223646111 family with sequence similarity 157, member B [Homo... 28 8.1
>gi|40786394 fumarylacetoacetate hydrolase domain containing 2B
[Homo sapiens]
Length = 314
Score = 644 bits (1660), Expect = 0.0
Identities = 314/314 (100%), Positives = 314/314 (100%)
Query: 1 MLVSGRRRLLTALLQAQKWPFQPSRDMRLVQFRAPHLVGPHLGLETGNGGGVINLNAFDP 60
MLVSGRRRLLTALLQAQKWPFQPSRDMRLVQFRAPHLVGPHLGLETGNGGGVINLNAFDP
Sbjct: 1 MLVSGRRRLLTALLQAQKWPFQPSRDMRLVQFRAPHLVGPHLGLETGNGGGVINLNAFDP 60
Query: 61 TLPKTMTQFLEQGEATLSVARRALAAQLPVLPWSEVTFLAPVTWPDKVVCVGMNYVDHCK 120
TLPKTMTQFLEQGEATLSVARRALAAQLPVLPWSEVTFLAPVTWPDKVVCVGMNYVDHCK
Sbjct: 61 TLPKTMTQFLEQGEATLSVARRALAAQLPVLPWSEVTFLAPVTWPDKVVCVGMNYVDHCK 120
Query: 121 EQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELAVVIGKKGKHIKATDAMA 180
EQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELAVVIGKKGKHIKATDAMA
Sbjct: 121 EQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELAVVIGKKGKHIKATDAMA 180
Query: 181 HVAGFTVAHDVSARDWLTRRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVN 240
HVAGFTVAHDVSARDWLTRRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVN
Sbjct: 181 HVAGFTVAHDVSARDWLTRRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVN 240
Query: 241 GEVVQSSNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPPGVGVFRKPPVFLKKGDEVQ 300
GEVVQSSNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPPGVGVFRKPPVFLKKGDEVQ
Sbjct: 241 GEVVQSSNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPPGVGVFRKPPVFLKKGDEVQ 300
Query: 301 CEIEELGVIINKVV 314
CEIEELGVIINKVV
Sbjct: 301 CEIEELGVIINKVV 314
>gi|156231349 fumarylacetoacetate hydrolase domain containing 2A
[Homo sapiens]
Length = 314
Score = 625 bits (1612), Expect = e-179
Identities = 308/314 (98%), Positives = 308/314 (98%)
Query: 1 MLVSGRRRLLTALLQAQKWPFQPSRDMRLVQFRAPHLVGPHLGLETGNGGGVINLNAFDP 60
MLVSGRRRLLT LLQAQKWPFQPSRDMRLVQFRAPHLVGPHLGLETGNGGGVINLNAFDP
Sbjct: 1 MLVSGRRRLLTVLLQAQKWPFQPSRDMRLVQFRAPHLVGPHLGLETGNGGGVINLNAFDP 60
Query: 61 TLPKTMTQFLEQGEATLSVARRALAAQLPVLPWSEVTFLAPVTWPDKVVCVGMNYVDHCK 120
TLPKTMTQFLEQGEATLSVARRALAAQLPVLP SEVTFLAPVT PDKVVCVGMNYVDHCK
Sbjct: 61 TLPKTMTQFLEQGEATLSVARRALAAQLPVLPRSEVTFLAPVTRPDKVVCVGMNYVDHCK 120
Query: 121 EQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELAVVIGKKGKHIKATDAMA 180
EQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELAVVIGKKGKHIKATDAMA
Sbjct: 121 EQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELAVVIGKKGKHIKATDAMA 180
Query: 181 HVAGFTVAHDVSARDWLTRRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVN 240
HVAGFTVAHDVSARDW RRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVN
Sbjct: 181 HVAGFTVAHDVSARDWQMRRNGKQWLLGKTFDTFCPLGPALVTKDSVADPHNLKICCRVN 240
Query: 241 GEVVQSSNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPPGVGVFRKPPVFLKKGDEVQ 300
GEVVQS NTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPPGVGVFRKPPVFLKKGDEVQ
Sbjct: 241 GEVVQSGNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPPGVGVFRKPPVFLKKGDEVQ 300
Query: 301 CEIEELGVIINKVV 314
CEIEELGVIINKVV
Sbjct: 301 CEIEELGVIINKVV 314
>gi|13654274 fumarylacetoacetate hydrolase domain containing 1
isoform 2 [Homo sapiens]
Length = 224
Score = 144 bits (363), Expect = 1e-34
Identities = 78/212 (36%), Positives = 122/212 (57%), Gaps = 10/212 (4%)
Query: 104 WPDKVVCVGMNYVDHCKEQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELA 163
W +VCVG NY DH +E V EP++F K +++ +++P ++ + E+EL
Sbjct: 16 WGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPILMPAYTRNLHHELELG 75
Query: 164 VVIGKKGKHIKATDAMAHVAGFTVAHDVSARDWLT--RRNGKQWLLGKTFDTFCPLGPAL 221
VV+GK+ + + AM +V G+ + D++ARD ++ G W L K+F CP+ A
Sbjct: 76 VVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWTLAKSFTASCPVS-AF 134
Query: 222 VTKDSVADPHNLKICCRVNGEVVQSSNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPP 281
V K+ + DPH LK+ +VNGE+ Q T+ M+F +I++VS+ +T GD+ILTGTP
Sbjct: 135 VPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKIITLEEGDIILTGTPK 194
Query: 282 GVGVFRKPPVFLKKGDEVQCEIEELGVIINKV 313
GVG PV K+ DE++ I L + KV
Sbjct: 195 GVG-----PV--KENDEIEAGIHGLVSMTFKV 219
>gi|215422413 fumarylacetoacetate hydrolase domain containing 1
isoform 3 [Homo sapiens]
Length = 226
Score = 144 bits (362), Expect = 1e-34
Identities = 76/205 (37%), Positives = 119/205 (58%), Gaps = 10/205 (4%)
Query: 104 WPDKVVCVGMNYVDHCKEQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELA 163
W +VCVG NY DH +E V EP++F K +++ +++P ++ + E+EL
Sbjct: 16 WGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPILMPAYTRNLHHELELG 75
Query: 164 VVIGKKGKHIKATDAMAHVAGFTVAHDVSARDWLT--RRNGKQWLLGKTFDTFCPLGPAL 221
VV+GK+ + + AM +V G+ + D++ARD ++ G W L K+F CP+ A
Sbjct: 76 VVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWTLAKSFTASCPVS-AF 134
Query: 222 VTKDSVADPHNLKICCRVNGEVVQSSNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPP 281
V K+ + DPH LK+ +VNGE+ Q T+ M+F +I++VS+ +T GD+ILTGTP
Sbjct: 135 VPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKIITLEEGDIILTGTPK 194
Query: 282 GVGVFRKPPVFLKKGDEVQCEIEEL 306
GVG PV K+ DE++ I L
Sbjct: 195 GVG-----PV--KENDEIEAGIHGL 212
>gi|66348062 fumarylacetoacetate hydrolase domain containing 1
isoform 1 [Homo sapiens]
Length = 248
Score = 144 bits (362), Expect = 1e-34
Identities = 76/205 (37%), Positives = 119/205 (58%), Gaps = 10/205 (4%)
Query: 104 WPDKVVCVGMNYVDHCKEQNVPVPKEPIIFSKFASSIVGPYDEVVLPPQSQEVDWEVELA 163
W +VCVG NY DH +E V EP++F K +++ +++P ++ + E+EL
Sbjct: 16 WGKNIVCVGRNYADHVREMRSAVLSEPVLFLKPSTAYAPEGSPILMPAYTRNLHHELELG 75
Query: 164 VVIGKKGKHIKATDAMAHVAGFTVAHDVSARDWLT--RRNGKQWLLGKTFDTFCPLGPAL 221
VV+GK+ + + AM +V G+ + D++ARD ++ G W L K+F CP+ A
Sbjct: 76 VVMGKRCRAVPEAAAMDYVGGYALCLDMTARDVQDECKKKGLPWTLAKSFTASCPVS-AF 134
Query: 222 VTKDSVADPHNLKICCRVNGEVVQSSNTNQMVFKTEDLIAWVSQFVTFYPGDVILTGTPP 281
V K+ + DPH LK+ +VNGE+ Q T+ M+F +I++VS+ +T GD+ILTGTP
Sbjct: 135 VPKEKIPDPHKLKLWLKVNGELRQEGETSSMIFSIPYIISYVSKIITLEEGDIILTGTPK 194
Query: 282 GVGVFRKPPVFLKKGDEVQCEIEEL 306
GVG PV K+ DE++ I L
Sbjct: 195 GVG-----PV--KENDEIEAGIHGL 212
>gi|170784824 paired box 4 [Homo sapiens]
Length = 343
Score = 33.1 bits (74), Expect = 0.33
Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 7/87 (8%)
Query: 3 VSGRRRLLTALLQAQKWPFQPSRDMRLVQFRAPHLVGPHLGLETGNGG----GVINLNAF 58
VS R+L AL + Q P R ++ AP ++ PH G ET G G N F
Sbjct: 113 VSSINRVLRALQEDQGLPCTRLRSPAVL---APAVLTPHSGSETPRGTHPGTGHRNRTIF 169
Query: 59 DPTLPKTMTQFLEQGEATLSVARRALA 85
P+ + + + ++G+ SVAR LA
Sbjct: 170 SPSQAEALEKEFQRGQYPDSVARGKLA 196
>gi|48762700 GTF2I repeat domain containing 2 [Homo sapiens]
Length = 949
Score = 29.6 bits (65), Expect = 3.6
Identities = 13/23 (56%), Positives = 17/23 (73%), Gaps = 1/23 (4%)
Query: 267 VTFYPGDVILTGTPPGVGVFRKP 289
+TF PG V++ G PPGV VF+ P
Sbjct: 361 ITFNPGCVVIDGMPPGV-VFKAP 382
>gi|51241788 GTF2I repeat domain containing 2B [Homo sapiens]
Length = 949
Score = 29.6 bits (65), Expect = 3.6
Identities = 13/23 (56%), Positives = 17/23 (73%), Gaps = 1/23 (4%)
Query: 267 VTFYPGDVILTGTPPGVGVFRKP 289
+TF PG V++ G PPGV VF+ P
Sbjct: 361 ITFNPGCVVIDGMPPGV-VFKAP 382
>gi|223646109 family with sequence similarity 157, member A [Homo
sapiens]
Length = 383
Score = 28.5 bits (62), Expect = 8.1
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 4/80 (5%)
Query: 125 PVPKEPIIFSKFAS-SIVGPYDEVVLPPQSQEV--DW-EVELAVVIGKKGKHIKATDAMA 180
P P++P+ ++ S + GP+ PP Q + DW V +GK + + A
Sbjct: 246 PPPQDPLGRRRWLSRNTWGPWPGTTQPPSPQLLRNDWGSCGFMVPEAARGKVFQDSQEGA 305
Query: 181 HVAGFTVAHDVSARDWLTRR 200
H+ TV+ V A W +R
Sbjct: 306 HIRRETVSKSVCAEPWRHQR 325
>gi|239743047 PREDICTED: similar to family with sequence similarity
157, member B [Homo sapiens]
Length = 384
Score = 28.5 bits (62), Expect = 8.1
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 4/80 (5%)
Query: 125 PVPKEPIIFSKFAS-SIVGPYDEVVLPPQSQEV--DW-EVELAVVIGKKGKHIKATDAMA 180
P P++P+ ++ S + GP+ PP Q + DW V +GK + + A
Sbjct: 247 PPPQDPLGRRRWLSRNTWGPWPGTTQPPSPQLLRNDWGSCGFMVPEAARGKVFQDSQEGA 306
Query: 181 HVAGFTVAHDVSARDWLTRR 200
H+ TV+ V A W +R
Sbjct: 307 HIRRETVSKSVCAEPWRHQR 326
>gi|7705387 GTF2I repeat domain containing 1 isoform 1 [Homo
sapiens]
Length = 959
Score = 28.5 bits (62), Expect = 8.1
Identities = 13/22 (59%), Positives = 15/22 (68%), Gaps = 1/22 (4%)
Query: 271 PGDVILTGTPPGVGVFRKPPVF 292
PG VI+ G PPG+ FRKP F
Sbjct: 738 PGSVIIEGLPPGI-PFRKPCTF 758
>gi|15011924 GTF2I repeat domain containing 1 isoform 2 [Homo
sapiens]
Length = 944
Score = 28.5 bits (62), Expect = 8.1
Identities = 13/22 (59%), Positives = 15/22 (68%), Gaps = 1/22 (4%)
Query: 271 PGDVILTGTPPGVGVFRKPPVF 292
PG VI+ G PPG+ FRKP F
Sbjct: 723 PGSVIIEGLPPGI-PFRKPCTF 743
>gi|223646111 family with sequence similarity 157, member B [Homo
sapiens]
Length = 384
Score = 28.5 bits (62), Expect = 8.1
Identities = 22/80 (27%), Positives = 36/80 (45%), Gaps = 4/80 (5%)
Query: 125 PVPKEPIIFSKFAS-SIVGPYDEVVLPPQSQEV--DW-EVELAVVIGKKGKHIKATDAMA 180
P P++P+ ++ S + GP+ PP Q + DW V +GK + + A
Sbjct: 247 PPPQDPLGRRRWLSRNTWGPWPGTTQPPSPQLLRNDWGSCGFMVPEAARGKVFQDSQEGA 306
Query: 181 HVAGFTVAHDVSARDWLTRR 200
H+ TV+ V A W +R
Sbjct: 307 HIRRETVSKSVCAEPWRHQR 326
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,136,661
Number of Sequences: 37866
Number of extensions: 597171
Number of successful extensions: 1254
Number of sequences better than 10.0: 13
Number of HSP's better than 10.0 without gapping: 5
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1243
Number of HSP's gapped (non-prelim): 13
length of query: 314
length of database: 18,247,518
effective HSP length: 102
effective length of query: 212
effective length of database: 14,385,186
effective search space: 3049659432
effective search space used: 3049659432
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.