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Search of human proteins with 38569405
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
(533 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens] 1129 0.0
gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens] 845 0.0
gi|109389362 arylsulfatase J [Homo sapiens] 550 e-157
gi|59797060 arylsulfatase family, member I [Homo sapiens] 545 e-155
gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precurso... 176 4e-44
gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens] 152 1e-36
gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens] 152 1e-36
gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens] 152 1e-36
gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens] 152 1e-36
gi|157266309 arylsulfatase E precursor [Homo sapiens] 137 2e-32
gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens] 129 9e-30
gi|45430057 Arylsulfatase G [Homo sapiens] 122 6e-28
gi|53831991 steryl-sulfatase precursor [Homo sapiens] 105 8e-23
gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens] 99 1e-20
gi|31742482 arylsulfatase F precursor [Homo sapiens] 98 2e-20
gi|58743319 arylsulfatase family, member H [Homo sapiens] 87 3e-17
gi|146229327 arylsulfatase A isoform b [Homo sapiens] 84 3e-16
gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo sap... 80 6e-15
gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens] 68 2e-11
gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens] 64 3e-10
gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens] 56 7e-08
gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens] 56 7e-08
gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens] 56 7e-08
gi|189571643 sulfatase 1 [Homo sapiens] 55 2e-07
gi|189571641 sulfatase 1 [Homo sapiens] 55 2e-07
gi|189571638 sulfatase 1 [Homo sapiens] 55 2e-07
gi|189571636 sulfatase 1 [Homo sapiens] 55 2e-07
gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo sa... 52 2e-06
gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter... 43 8e-04
gi|39930577 arylsulfatase K [Homo sapiens] 42 0.002
>gi|38569405 arylsulfatase B isoform 1 precursor [Homo sapiens]
Length = 533
Score = 1129 bits (2921), Expect = 0.0
Identities = 533/533 (100%), Positives = 533/533 (100%)
Query: 1 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 60
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV
Sbjct: 1 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 60
Query: 61 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 120
GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS
Sbjct: 61 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 120
Query: 121 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 180
CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER
Sbjct: 121 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 180
Query: 181 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 240
CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS
Sbjct: 181 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 240
Query: 241 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 300
VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD
Sbjct: 241 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 300
Query: 301 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL
Sbjct: 301 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
Query: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP 420
ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP
Sbjct: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP 420
Query: 421 EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD 480
EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD
Sbjct: 421 EYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRD 480
Query: 481 PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM 533
PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM
Sbjct: 481 PEERHDLSREYPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM 533
>gi|38569407 arylsulfatase B isoform 2 precursor [Homo sapiens]
Length = 413
Score = 845 bits (2182), Expect = 0.0
Identities = 404/404 (100%), Positives = 404/404 (100%)
Query: 1 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 60
MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV
Sbjct: 1 MGPRGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDV 60
Query: 61 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 120
GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS
Sbjct: 61 GFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPS 120
Query: 121 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 180
CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER
Sbjct: 121 CVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHER 180
Query: 181 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 240
CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS
Sbjct: 181 CTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQS 240
Query: 241 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 300
VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD
Sbjct: 241 VHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTD 300
Query: 301 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL
Sbjct: 301 NGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
Query: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSP 404
ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSP
Sbjct: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSP 404
>gi|109389362 arylsulfatase J [Homo sapiens]
Length = 599
Score = 550 bits (1418), Expect = e-157
Identities = 284/572 (49%), Positives = 365/572 (63%), Gaps = 58/572 (10%)
Query: 1 MGPRGAASLPRGPGPRRLLLPVVLP---------LLLLL------------------LLA 33
M PRG A P P P+ + P + +L LL LLA
Sbjct: 1 MAPRGCAGHPPPPSPQACVCPGKMLAMGALAGFWILCLLTYGYLSWGQALEEEEEGALLA 60
Query: 34 PPGS----GAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQP 89
G ++ PHL+F+LADD G+ DVG+HGS I+TP LD LAA GV L+NYY QP
Sbjct: 61 QAGEKLEPSTTSTSQPHLIFILADDQGFRDVGYHGSEIKTPTLDKLAAEGVKLENYYVQP 120
Query: 90 LCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLG 149
+CTPSRSQ +TG+YQI TGLQH II P QP+C+PLD LPQ LKE GY+THMVGKWHLG
Sbjct: 121 ICTPSRSQFITGKYQIHTGLQHSIIRPTQPNCLPLDNATLPQKLKEVGYSTHMVGKWHLG 180
Query: 150 MYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKN- 208
YRKEC+PTRRGFDT+FG LLGS DYY+H +C + C D + + A Y N
Sbjct: 181 FYRKECMPTRRGFDTFFGSLLGSGDYYTHYKCD-----SPGMCGYDLYENDNAAWDYDNG 235
Query: 209 MYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAG 268
+YST ++T+R ++ +H P KP+FLY+A Q+VH PLQ P Y + Y I + NR YA
Sbjct: 236 IYSTQMYTQRVQQILASHNPTKPIFLYIAYQAVHSPLQAPGRYFEHYRSIININRRRYAA 295
Query: 269 MVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRG 328
M+S +DEA+ NVT ALK+ G +NN++ I+S+DNGGQ AGG+NWPLRG K + WEGG+R
Sbjct: 296 MLSCLDEAINNVTLALKTYGFYNNSIIIYSSDNGGQPTAGGSNWPLRGSKGTYWEGGIRA 355
Query: 329 VGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPR 388
VGFV SPLLK KG +EL+HI+DW PTL+ LA G + LDG+D+W+TISEG SPR
Sbjct: 356 VGFVHSPLLKNKGTVCKELVHITDWYPTLISLAEGQIDEDIQLDGYDIWETISEGLRSPR 415
Query: 389 IELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCG 448
+++LHNIDP + AK+ S Y +NT++ +AIR +WKLLTG PG
Sbjct: 416 VDILHNIDPIY-----------TKAKNGSWAAGYGIWNTAIQSAIRVQHWKLLTGNPGYS 464
Query: 449 YWFPP-------PSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSR 501
W PP P++++ I S K++WLF+I DP ER DLS YP IV KLL R
Sbjct: 465 DWVPPQSFSNLGPNRWHNERITLS--TGKSVWLFNITADPYERVDLSNRYPGIVKKLLRR 522
Query: 502 LQFYHKHSVPVYFPAQDPRCDPKAT-GVWGPW 532
L ++K +VPV +P +DPR +P+ GVWGPW
Sbjct: 523 LSQFNKTAVPVRYPPKDPRSNPRLNGGVWGPW 554
>gi|59797060 arylsulfatase family, member I [Homo sapiens]
Length = 569
Score = 545 bits (1405), Expect = e-155
Identities = 274/502 (54%), Positives = 344/502 (68%), Gaps = 27/502 (5%)
Query: 39 AGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDNYYTQPLCTPSRSQL 98
A +PPH++F+L DD G++DVG+HGS I TP LD LAA GV L+NYY QP+CTPSRSQL
Sbjct: 41 AAPPQPPHIIFILTDDQGYHDVGYHGSDIETPTLDRLAAKGVKLENYYIQPICTPSRSQL 100
Query: 99 LTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECLPT 158
LTGRYQI TGLQH II P QP+C+PLD+ LPQ L+EAGY+THMVGKWHLG YRKECLPT
Sbjct: 101 LTGRYQIHTGLQHSIIRPQQPNCLPLDQVTLPQKLQEAGYSTHMVGKWHLGFYRKECLPT 160
Query: 159 RRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKR 218
RRGFDT+ G L G+ DYY+++ C D V C D +GE VA G YST ++ +R
Sbjct: 161 RRGFDTFLGSLTGNVDYYTYDNC---DGPGV--CGFDLHEGENVAWGLSGQYSTMLYAQR 215
Query: 219 AIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVG 278
A ++ +H P++PLFLY+A Q+VH PLQ P EYL Y + + R YA MV+ MDEAV
Sbjct: 216 ASHILASHSPQRPLFLYVAFQAVHTPLQSPREYLYRYRTMGNVARRKYAAMVTCMDEAVR 275
Query: 279 NVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLK 338
N+T ALK G +NN+V IFS+DNGGQT +GG+NWPLRGRK + WEGGVRG+GFV SPLLK
Sbjct: 276 NITWALKRYGFYNNSVIIFSSDNGGQTFSGGSNWPLRGRKGTYWEGGVRGLGFVHSPLLK 335
Query: 339 QKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPN 398
+K +R L+HI+DW PTLV LA G T+ LDG+DVW ISEG SPR E+LHNIDP
Sbjct: 336 RKQRTSRALMHITDWYPTLVGLAGGTTSAADGLDGYDVWPAISEGRASPRTEILHNIDPL 395
Query: 399 FVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPP---- 454
+ A+ S + +NT+V AAIR G WKLLTG PG G W PP
Sbjct: 396 Y-----------NHAQHGSLEGGFGIWNTAVQAAIRVGEWKLLTGDPGYGDWIPPQTLAT 444
Query: 455 ---SQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRLQFYHKHSVP 511
S +N+ + S + +WLF+I DP ER DL+ + P +V LL+RL Y++ ++P
Sbjct: 445 FPGSWWNLERMAS---VRQAVWLFNISADPYEREDLAGQRPDVVRTLLARLAEYNRTAIP 501
Query: 512 VYFPAQDPRCDPKAT-GVWGPW 532
V +PA++PR P G WGPW
Sbjct: 502 VRYPAENPRAHPDFNGGAWGPW 523
>gi|4503899 galactosamine (N-acetyl)-6-sulfate sulfatase precursor
[Homo sapiens]
Length = 522
Score = 176 bits (447), Expect = 4e-44
Identities = 157/516 (30%), Positives = 238/516 (46%), Gaps = 79/516 (15%)
Query: 28 LLLLLAPPGSGA-GASRPPHLVFLLADDLGWNDVGFHGSRIR-TPHLDALAAGGVLLDNY 85
LLL+L+ G GA GA +PP+++ LL DD+GW D+G +G R TP+LD +AA G+L N+
Sbjct: 13 LLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNF 72
Query: 86 YT-QPLCTPSRSQLLTGRYQIRTGLQ------HQIIWPCQ-PSCVPLDEKLLPQLLKEAG 137
Y+ PLC+PSR+ LLTGR IR G P + +P E+LLP+LLK+AG
Sbjct: 73 YSANPLCSPSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAG 132
Query: 138 YTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRCALD-F 196
Y + +VGKWHLG +R + P + GFD +FG C N R + +
Sbjct: 133 YVSKIVGKWHLG-HRPQFHPLKHGFDEWFG----------SPNCHFGPYDNKARPNIPVY 181
Query: 197 RDGEEVA-----------TGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPL 245
RD E V TG N+ T I+ + A+ I P FLY A+ + H P+
Sbjct: 182 RDWEMVGRYYEEFPINLKTGEANL--TQIYLQEALDFIKRQARHHPFFLYWAVDATHAPV 239
Query: 246 QVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQT 305
KP F+ R Y V +D+++G + L+ + +NT F++DNG
Sbjct: 240 YAS----KP--FLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAAL 293
Query: 306 LA----GGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLA 361
++ GG+N P K + +EGG+R P G + +L I D T + LA
Sbjct: 294 ISAPEQGGSNGPFLCGKQTTFEGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALA 353
Query: 362 RGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPE 421
+ +DG ++ T+ +G R + D ++L +
Sbjct: 354 GLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMA----------------ATLGQ 397
Query: 422 YSAFNTSVHAAIRHGNWK-LLTGYPGCGYWFPPPSQYNVSEIPSS--DPPTKTLWLFDID 478
+ A H +W+ G C P Q NVS + + + TK +F +
Sbjct: 398 HKA-----HFWTWTNSWENFRQGIDFC------PGQ-NVSGVTTHNLEDHTKLPLIFHLG 445
Query: 479 RDPEERHDL---SREYPHIVTKLLSRLQFYHKHSVP 511
RDP ER L S EY ++++ S +Q + + VP
Sbjct: 446 RDPGERFPLSFASAEYQEALSRITSVVQQHQEALVP 481
>gi|146229331 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 152 bits (383), Expect = 1e-36
Identities = 146/491 (29%), Positives = 208/491 (42%), Gaps = 81/491 (16%)
Query: 25 PLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGS-RIRTPHLDALAAGGVLLD 83
P LLL LA +G +RPP++V + ADDLG+ D+G +G TP+LD LAAGG+
Sbjct: 4 PRSLLLALA---AGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
Query: 84 NYYTQ-PLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHM 142
++Y LCTPSR+ LLTGR +R G+ ++ P +PL+E + ++L GY T M
Sbjct: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
Query: 143 VGKWHLGMYRKEC-LPTRRGFDTYFGYLLGSEDYYSHER--CTLIDAL-NVTRC------ 192
GKWHLG+ + LP +GF + G YSH++ C + T C
Sbjct: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQ 174
Query: 193 ---------ALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHE 243
L G + Y A A ++P FLY A H
Sbjct: 175 GLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADA----QRQDRPFFLYYASHHTHY 230
Query: 244 PLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGG 303
P F + R + + +D AVG + A+ GL T+ IF+ DNG
Sbjct: 231 P------QFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGP 284
Query: 304 QTL---AGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
+T+ GG + LR K + +EGGVR P GV EL D LPTL L
Sbjct: 285 ETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV-THELASSLDLLPTLAAL 343
Query: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP 420
A G LDGFD+ + SPR SL
Sbjct: 344 A-GAPLPNVTLDGFDLSPLLLGTGKSPR----------------------------QSLF 374
Query: 421 EYSAFNTSVHA--AIRHGNWKLLTGYPGCGY--WFPPPSQYNVSEIPSSDPPTKTLWLFD 476
Y ++ V A+R G +K G + P+ + S + + +PP L+D
Sbjct: 375 FYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPL----LYD 430
Query: 477 IDRDPEERHDL 487
+ +DP E ++L
Sbjct: 431 LSKDPGENYNL 441
>gi|146229329 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 152 bits (383), Expect = 1e-36
Identities = 146/491 (29%), Positives = 208/491 (42%), Gaps = 81/491 (16%)
Query: 25 PLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGS-RIRTPHLDALAAGGVLLD 83
P LLL LA +G +RPP++V + ADDLG+ D+G +G TP+LD LAAGG+
Sbjct: 4 PRSLLLALA---AGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
Query: 84 NYYTQ-PLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHM 142
++Y LCTPSR+ LLTGR +R G+ ++ P +PL+E + ++L GY T M
Sbjct: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
Query: 143 VGKWHLGMYRKEC-LPTRRGFDTYFGYLLGSEDYYSHER--CTLIDAL-NVTRC------ 192
GKWHLG+ + LP +GF + G YSH++ C + T C
Sbjct: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQ 174
Query: 193 ---------ALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHE 243
L G + Y A A ++P FLY A H
Sbjct: 175 GLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADA----QRQDRPFFLYYASHHTHY 230
Query: 244 PLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGG 303
P F + R + + +D AVG + A+ GL T+ IF+ DNG
Sbjct: 231 P------QFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGP 284
Query: 304 QTL---AGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
+T+ GG + LR K + +EGGVR P GV EL D LPTL L
Sbjct: 285 ETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV-THELASSLDLLPTLAAL 343
Query: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP 420
A G LDGFD+ + SPR SL
Sbjct: 344 A-GAPLPNVTLDGFDLSPLLLGTGKSPR----------------------------QSLF 374
Query: 421 EYSAFNTSVHA--AIRHGNWKLLTGYPGCGY--WFPPPSQYNVSEIPSSDPPTKTLWLFD 476
Y ++ V A+R G +K G + P+ + S + + +PP L+D
Sbjct: 375 FYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPL----LYD 430
Query: 477 IDRDPEERHDL 487
+ +DP E ++L
Sbjct: 431 LSKDPGENYNL 441
>gi|146229324 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 152 bits (383), Expect = 1e-36
Identities = 146/491 (29%), Positives = 208/491 (42%), Gaps = 81/491 (16%)
Query: 25 PLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGS-RIRTPHLDALAAGGVLLD 83
P LLL LA +G +RPP++V + ADDLG+ D+G +G TP+LD LAAGG+
Sbjct: 4 PRSLLLALA---AGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
Query: 84 NYYTQ-PLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHM 142
++Y LCTPSR+ LLTGR +R G+ ++ P +PL+E + ++L GY T M
Sbjct: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
Query: 143 VGKWHLGMYRKEC-LPTRRGFDTYFGYLLGSEDYYSHER--CTLIDAL-NVTRC------ 192
GKWHLG+ + LP +GF + G YSH++ C + T C
Sbjct: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQ 174
Query: 193 ---------ALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHE 243
L G + Y A A ++P FLY A H
Sbjct: 175 GLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADA----QRQDRPFFLYYASHHTHY 230
Query: 244 PLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGG 303
P F + R + + +D AVG + A+ GL T+ IF+ DNG
Sbjct: 231 P------QFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGP 284
Query: 304 QTL---AGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
+T+ GG + LR K + +EGGVR P GV EL D LPTL L
Sbjct: 285 ETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV-THELASSLDLLPTLAAL 343
Query: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP 420
A G LDGFD+ + SPR SL
Sbjct: 344 A-GAPLPNVTLDGFDLSPLLLGTGKSPR----------------------------QSLF 374
Query: 421 EYSAFNTSVHA--AIRHGNWKLLTGYPGCGY--WFPPPSQYNVSEIPSSDPPTKTLWLFD 476
Y ++ V A+R G +K G + P+ + S + + +PP L+D
Sbjct: 375 FYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPL----LYD 430
Query: 477 IDRDPEERHDL 487
+ +DP E ++L
Sbjct: 431 LSKDPGENYNL 441
>gi|6005990 arylsulfatase A isoform a precursor [Homo sapiens]
Length = 507
Score = 152 bits (383), Expect = 1e-36
Identities = 146/491 (29%), Positives = 208/491 (42%), Gaps = 81/491 (16%)
Query: 25 PLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGS-RIRTPHLDALAAGGVLLD 83
P LLL LA +G +RPP++V + ADDLG+ D+G +G TP+LD LAAGG+
Sbjct: 4 PRSLLLALA---AGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFT 60
Query: 84 NYYTQ-PLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHM 142
++Y LCTPSR+ LLTGR +R G+ ++ P +PL+E + ++L GY T M
Sbjct: 61 DFYVPVSLCTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGM 120
Query: 143 VGKWHLGMYRKEC-LPTRRGFDTYFGYLLGSEDYYSHER--CTLIDAL-NVTRC------ 192
GKWHLG+ + LP +GF + G YSH++ C + T C
Sbjct: 121 AGKWHLGVGPEGAFLPPHQGFHRFLGI------PYSHDQGPCQNLTCFPPATPCDGGCDQ 174
Query: 193 ---------ALDFRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHE 243
L G + Y A A ++P FLY A H
Sbjct: 175 GLVPIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADA----QRQDRPFFLYYASHHTHY 230
Query: 244 PLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGG 303
P F + R + + +D AVG + A+ GL T+ IF+ DNG
Sbjct: 231 P------QFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGP 284
Query: 304 QTL---AGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
+T+ GG + LR K + +EGGVR P GV EL D LPTL L
Sbjct: 285 ETMRMSRGGCSGLLRCGKGTTYEGGVREPALAFWPGHIAPGV-THELASSLDLLPTLAAL 343
Query: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLP 420
A G LDGFD+ + SPR SL
Sbjct: 344 A-GAPLPNVTLDGFDLSPLLLGTGKSPR----------------------------QSLF 374
Query: 421 EYSAFNTSVHA--AIRHGNWKLLTGYPGCGY--WFPPPSQYNVSEIPSSDPPTKTLWLFD 476
Y ++ V A+R G +K G + P+ + S + + +PP L+D
Sbjct: 375 FYPSYPDEVRGVFAVRTGKYKAHFFTQGSAHSDTTADPACHASSSLTAHEPPL----LYD 430
Query: 477 IDRDPEERHDL 487
+ +DP E ++L
Sbjct: 431 LSKDPGENYNL 441
>gi|157266309 arylsulfatase E precursor [Homo sapiens]
Length = 589
Score = 137 bits (346), Expect = 2e-32
Identities = 160/586 (27%), Positives = 243/586 (41%), Gaps = 112/586 (19%)
Query: 26 LLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDN 84
L +LL LAP S ++ P+++ L+ADDLG D+G +G+ +RTP++D LA GV L
Sbjct: 19 LAVLLSLAPSASSDISASRPNILLLMADDLGIGDIGCYGNNTMRTPNIDRLAEDGVKLTQ 78
Query: 85 YYTQP-LCTPSRSQLLTGRYQIRTGLQHQI-----IWPCQPSCVPLDEKLLPQLLKEAGY 138
+ + LCTPSR+ LTGRY +R+G+ I W +P +E ++LKE GY
Sbjct: 79 HISAASLCTPSRAAFLTGRYPVRSGMVSSIGYRVLQWTGASGGLPTNETTFAKILKEKGY 138
Query: 139 TTHMVGKWHLGMYRKECL-----PTRRGFDTYFGY---LLG--SEDYYSHERCTLIDALN 188
T ++GKWHLG+ + P GFD ++G L+G + S +R L LN
Sbjct: 139 ATGLIGKWHLGLNCESASDHCHHPLHHGFDHFYGMPFSLMGDCARWELSEKRVNLEQKLN 198
Query: 189 -----VTRCALDFRDGEEV-------------ATGYKNMYSTNIFTKRAIA-----LITN 225
+ AL G+ A + +++ F I L+ N
Sbjct: 199 FLFQVLALVALTLVAGKLTHLIPVSWMPVIWSALSAVLLLASSYFVGALIVHADCFLMRN 258
Query: 226 HP-PEKPLFLY----LALQSV--------HEPLQVPEEYLKPY-------DFIQDKNRHH 265
H E+P+ L LQ V H P + +L + +F+
Sbjct: 259 HTITEQPMCFQRTTPLILQEVASFLKRNKHGPFLLFVSFLHVHIPLITMENFLGKSLHGL 318
Query: 266 YAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNG-------GQTLAGGNNWPLRGRK 318
Y V MD VG + L GL N+T+ F++D+G G T GG N +G K
Sbjct: 319 YGDNVEEMDWMVGRILDTLDVEGLSNSTLIYFTSDHGGSLENQLGNTQYGGWNGIYKGGK 378
Query: 319 -WSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVW 377
WEGG+R G P + G E + D PT+V+LA G + +DG D+
Sbjct: 379 GMGGWEGGIRVPGIFRWPGVLPAGRVIGEPTSLMDVFPTVVRLAGGEVPQDRVIDGQDLL 438
Query: 378 KTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGN 437
+ + E L + F+ ++ H R
Sbjct: 439 PLLLGTAQHSDHEFLMHYCERFLHAA------------------------RWHQRDRGTM 474
Query: 438 WKLLTGYP-----GCGYWFPPPSQYNVSE-IPSSDPPTKTLWLFDIDRDPEERHDLSREY 491
WK+ P G G + E + DPP LFD+ RDP E H L+
Sbjct: 475 WKVHFVTPVFQPEGAGACYGRKVCPCFGEKVVHHDPPL----LFDLSRDPSETHILTPAS 530
Query: 492 PHIVTKLLSRLQ---FYHKHSV-PVYFPAQDPRCDPKATGVWGPWM 533
+ +++ R+Q + H+ ++ PV P Q R +W PW+
Sbjct: 531 EPVFYQVMERVQQAVWEHQRTLSPV--PLQLDRLG----NIWRPWL 570
>gi|71852584 arylsulfatase D isoform a precursor [Homo sapiens]
Length = 593
Score = 129 bits (323), Expect = 9e-30
Identities = 128/448 (28%), Positives = 190/448 (42%), Gaps = 90/448 (20%)
Query: 4 RGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFH 63
R AA R R LPV+L L LLL P + A A +P +++ ++ADDLG D+G +
Sbjct: 2 RSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKT-ANAFKP-NILLIMADDLGTGDLGCY 59
Query: 64 GSR-IRTPHLDALAAGGVLLDNYYTQ-PLCTPSRSQLLTGRYQIRTGLQ-----HQIIWP 116
G+ +RTP++D LA GV L + PLCTPSR+ LTGR+ R+G+ + W
Sbjct: 60 GNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWN 119
Query: 117 CQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECL--------PTRRGFDTYFGY 168
+P +E ++L++ GY T ++GKWH G+ C P GFD ++G
Sbjct: 120 AGSGGLPENETTFARILQQHGYATGLIGKWHQGV---NCASRGDHCHHPLNHGFDYFYGM 176
Query: 169 LLGSEDYYSHERCTLID--------------ALNVTRCALD-----FRDGEEVATG---- 205
+ R +D AL + A F TG
Sbjct: 177 PFTLTNDCDPGRPPEVDAALRAQLWGYTQFLALGILTLAAGQTCGFFSVSARAVTGMAGV 236
Query: 206 ----YKNMYSTNIFTKR-AIALITNHP-PEKPL-------------------------FL 234
+ + YS+ F +R L+ NH E+P+ L
Sbjct: 237 GCLFFISWYSSFGFVRRWNCILMRNHDVTEQPMVLEKTASLMLKEAVSYIERHKHGPFLL 296
Query: 235 YLALQSVHEPLQVPEEYLKPYDFIQDKNRHH-YAGMVSLMDEAVGNVTAALKSSGLWNNT 293
+L+L VH PL +L K++H Y V MD +G V A++ +GL N+T
Sbjct: 297 FLSLLHVHIPLVTTSAFL-------GKSQHGLYGDNVEEMDWLIGKVLNAIEDNGLKNST 349
Query: 294 VFIFSTDNGG--------QTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNR 345
F++D+GG L G N G+ WEGG+R G P + G
Sbjct: 350 FTYFTSDHGGHLEARDGHSQLGGWNGIYKGGKGMGGWEGGIRVPGIFHWPGVLPAGRVIG 409
Query: 346 ELIHISDWLPTLVKLARGHTNGTKPLDG 373
E + D PT+V+L G + +DG
Sbjct: 410 EPTSLMDVFPTVVQLVGGEVPQDRVIDG 437
>gi|45430057 Arylsulfatase G [Homo sapiens]
Length = 525
Score = 122 bits (307), Expect = 6e-28
Identities = 113/387 (29%), Positives = 172/387 (44%), Gaps = 43/387 (11%)
Query: 37 SGAGASRPPHLVFLLADDLGWNDVGFHGSRIR-TPHLDALAAGGV-LLDNYYTQPLCTPS 94
SG + P+ V +LADD+GW D+G + + + T +LD +A+ G+ +D + C+PS
Sbjct: 28 SGKTRGQKPNFVIILADDMGWGDLGANWAETKDTANLDKMASEGMRFVDFHAAASTCSPS 87
Query: 95 RSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKE 154
R+ LLTGR +R G+ +PL+E L ++L++AGY T ++GKWHLG +
Sbjct: 88 RASLLTGRLGLRNGVTRNFA-VTSVGGLPLNETTLAEVLQQAGYVTGIIGKWHLG-HHGS 145
Query: 155 CLPTRRGFDTYFG----YLLGSEDY--YSHERCTLID-----ALNVTR-----CALDFRD 198
P RGFD YFG + +G D Y+H C + N+ R AL +
Sbjct: 146 YHPNFRGFDYYFGIPYSHDMGCTDTPGYNHPPCPACPQGDGPSRNLQRDCYTDVALPLYE 205
Query: 199 GEEVATGYKNMYS-TNIFTKRAIALITNHPPE-KPLFLYLALQSVHEPLQVPEEYLKPYD 256
+ N+ S + ++A I +P LY+AL +H PL V + P
Sbjct: 206 NLNIVEQPVNLSSLAQKYAEKATQFIQRASTSGRPFLLYVALAHMHVPLPVTQLPAAP-- 263
Query: 257 FIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQT----LAGGNN- 311
+ R Y + MD VG + + + + NT F+ DNG LAG
Sbjct: 264 ----RGRSLYGAGLWEMDSLVGQIKDKVDHT-VKENTFLWFTGDNGPWAQKCELAGSVGP 318
Query: 312 ----WPLRG----RKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARG 363
W R K + WEGG R P V + L+ + D PT+V LA+
Sbjct: 319 FTGFWQTRQGGSPAKQTTWEGGHRVPALAYWPGRVPVNVTSTALLSVLDIFPTVVALAQA 378
Query: 364 HTNGTKPLDGFDVWKTI-SEGSPSPRI 389
+ DG DV + + P R+
Sbjct: 379 SLPQGRRFDGVDVSEVLFGRSQPGHRV 405
>gi|53831991 steryl-sulfatase precursor [Homo sapiens]
Length = 583
Score = 105 bits (263), Expect = 8e-23
Identities = 65/159 (40%), Positives = 95/159 (59%), Gaps = 14/159 (8%)
Query: 24 LPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLL 82
+P LLL L S A ASRP +++ ++ADDLG D G +G++ IRTP++D LA+GGV L
Sbjct: 8 IPFLLLFFLWEAESHA-ASRP-NIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKL 65
Query: 83 DNYYT-QPLCTPSRSQLLTGRYQIRTGLQHQ-----IIWPCQPSCVPLDEKLLPQLLKEA 136
+ PLCTPSR+ +TGRY +R+G+ ++ +P DE +LLK+
Sbjct: 66 TQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQ 125
Query: 137 GYTTHMVGKWHLGM--YRKECL---PTRRGFDTYFGYLL 170
GY+T ++GKWHLGM + K P GF+ ++G L
Sbjct: 126 GYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISL 164
Score = 67.8 bits (164), Expect = 2e-11
Identities = 77/321 (23%), Positives = 121/321 (37%), Gaps = 54/321 (16%)
Query: 229 EKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSG 288
E P L L+ VH L DF Y V MD +VG + L
Sbjct: 277 ETPFLLVLSYLHVHTAL------FSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELR 330
Query: 289 LWNNTVFIFSTDNGGQT--------LAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQK 340
L N+T+ F++D G + GG+N +G K + WEGG+R G + P + Q
Sbjct: 331 LANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQA 390
Query: 341 GVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDPNFV 400
G K E D PT+ KLA + +DG D+ + S E L + ++
Sbjct: 391 GQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYL 450
Query: 401 DSSPC-PRNSMAPAKDDSSLPEYSAFNT----SVHAAIRHGNWKLLTGYPGCGYWFPPPS 455
++ P+NS + K P ++ + + H G++
Sbjct: 451 NAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSY----------------- 493
Query: 456 QYNVSEIPSSDPPTKTLWLFDIDRDPEERHDL---SREYPHIVTKLLSRLQFYHKHSVPV 512
+ DPP LFDI +DP ER+ L S + + K++ H ++P
Sbjct: 494 ------VTHHDPPL----LFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLP- 542
Query: 513 YFPAQDPRCDPKATGVWGPWM 533
+ P +W PW+
Sbjct: 543 ----EVPDQFSWNNFLWKPWL 559
>gi|71852586 arylsulfatase D isoform b precursor [Homo sapiens]
Length = 382
Score = 99.0 bits (245), Expect = 1e-20
Identities = 65/179 (36%), Positives = 96/179 (53%), Gaps = 20/179 (11%)
Query: 4 RGAASLPRGPGPRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFH 63
R AA R R LPV+L L LLL P + A A +P +++ ++ADDLG D+G +
Sbjct: 2 RSAARRGRAAPAARDSLPVLLFLCLLLKTCEPKT-ANAFKP-NILLIMADDLGTGDLGCY 59
Query: 64 GSR-IRTPHLDALAAGGVLLDNYYTQ-PLCTPSRSQLLTGRYQIRTGLQ-----HQIIWP 116
G+ +RTP++D LA GV L + PLCTPSR+ LTGR+ R+G+ + W
Sbjct: 60 GNNTLRTPNIDQLAEEGVRLTQHLAAAPLCTPSRAAFLTGRHSFRSGMDASNGYRALQWN 119
Query: 117 CQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKECL--------PTRRGFDTYFG 167
+P +E ++L++ GY T ++GKWH G+ C P GFD ++G
Sbjct: 120 AGSGGLPENETTFARILQQHGYATGLIGKWHQGV---NCASRGDHCHHPLNHGFDYFYG 175
>gi|31742482 arylsulfatase F precursor [Homo sapiens]
Length = 590
Score = 98.2 bits (243), Expect = 2e-20
Identities = 65/165 (39%), Positives = 93/165 (56%), Gaps = 15/165 (9%)
Query: 15 PRRLLLPVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGS-RIRTPHLD 73
PRR P+V L+ LL + P++V ++ DDLG D+G +G+ +RTPH+D
Sbjct: 3 PRR---PLVFMSLVCALLNTCQAHRVHDDKPNIVLIMVDDLGIGDLGCYGNDTMRTPHID 59
Query: 74 ALAAGGVLLDNYYTQP-LCTPSRSQLLTGRYQIRTGL-----QHQIIWPCQPSCVPLDEK 127
LA GV L + + LC+PSRS LTGRY IR+G+ + I P+ +PL+E
Sbjct: 60 RLAREGVRLTQHISAASLCSPSRSAFLTGRYPIRSGMVSSGNRRVIQNLAVPAGLPLNET 119
Query: 128 LLPQLLKEAGYTTHMVGKWHLGM----YRKEC-LPTRRGFDTYFG 167
L LLK+ GY+T ++GKWH G+ +C P GFD Y+G
Sbjct: 120 TLAALLKKQGYSTGLIGKWHQGLNCDSRSDQCHHPYNYGFDYYYG 164
Score = 72.4 bits (176), Expect = 1e-12
Identities = 89/361 (24%), Positives = 139/361 (38%), Gaps = 47/361 (13%)
Query: 166 FGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALITN 225
F +LLG + SH D L + R E K + +I K AI+ +
Sbjct: 225 FIFLLGYAWFSSHTSPLYWDCLLM-------RGHEITEQPMKAERAGSIMVKEAISFLER 277
Query: 226 HPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVTAALK 285
H E L L+ + VH PL + DF Y V MD VG + A+
Sbjct: 278 HSKETFL-LFFSFLHVHTPLPTTD------DFTGTSKHGLYGDNVEEMDSMVGKILDAID 330
Query: 286 SSGLWNNTVFIFSTDNGGQ--------TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLL 337
GL NNT+ F++D+GG L G N G+ WEGG+R G V P
Sbjct: 331 DFGLRNNTLVYFTSDHGGHLEARRGHAQLGGWNGIYKGGKGMGGWEGGIRVPGIVRWPGK 390
Query: 338 KQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDP 397
G +E + D LPT+ ++ G + +DG D+ + E L +
Sbjct: 391 VPAGRLIKEPTSLMDILPTVASVSGGSLPQDRVIDGRDLMPLLQGNVRHSEHEFLFHYCG 450
Query: 398 NFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHAAIRHGNWKLLTGYPGCGYWFPPPSQY 457
+++ + P KDDS + + T V G G + +
Sbjct: 451 SYLHAV-----RWIP-KDDSGSVWKAHYVTPVFQPPASG-----------GCYVTSLCRC 493
Query: 458 NVSEIPSSDPPTKTLWLFDIDRDPEERHDLSRE----YPHIVTKLLSRLQFYHKHSVPVY 513
++ +PP LFD+ RDP E L+ + ++ K+ + L+ + + VPV
Sbjct: 494 FGEQVTYHNPPL----LFDLSRDPSESTPLTPATEPLHDFVIKKVANALKEHQETIVPVT 549
Query: 514 F 514
+
Sbjct: 550 Y 550
>gi|58743319 arylsulfatase family, member H [Homo sapiens]
Length = 562
Score = 87.4 bits (215), Expect = 3e-17
Identities = 52/140 (37%), Positives = 75/140 (53%), Gaps = 13/140 (9%)
Query: 45 PHLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYTQP-LCTPSRSQLLTGR 102
P++V L+ADDLG D+ +G+ + TP++D LA+ GV L + +CTPSR+ LTGR
Sbjct: 7 PNIVLLMADDLGVGDLCCYGNNSVSTPNIDRLASEGVRLTQHLAAASMCTPSRAAFLTGR 66
Query: 103 YQIRTG------LQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGM----YR 152
Y IR+G L W +P +E +LL+ GY T ++GKWHLG+
Sbjct: 67 YPIRSGMVSAYNLNRAFTWLGGSGGLPTNETTFAKLLQHRGYRTGLIGKWHLGLSCASRN 126
Query: 153 KECL-PTRRGFDTYFGYLLG 171
C P GF ++G G
Sbjct: 127 DHCYHPLNHGFHYFYGVPFG 146
Score = 66.6 bits (161), Expect = 5e-11
Identities = 78/350 (22%), Positives = 130/350 (37%), Gaps = 50/350 (14%)
Query: 197 RDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYD 256
R+ E + K ++ K A+A I + E P L+ + VH PL +
Sbjct: 227 RNHEIIQQPMKEEKVASLMLKEALAFIERYKRE-PFLLFFSFLHVHTPL------ISKKK 279
Query: 257 FIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQ--------TLAG 308
F+ Y V MD VG + AL L N+T+ F++DNGG L G
Sbjct: 280 FVGRSKYGRYGDNVEEMDWMVGKILDALDQERLANHTLVYFTSDNGGHLEPLDGAVQLGG 339
Query: 309 GNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGT 368
N G+ WEGG+R G P + + G E + D PTL + G +
Sbjct: 340 WNGIYKGGKGMGGWEGGIRVPGIFRWPSVLEAGRVINEPTSLMDIYPTLSYIGGGILSQD 399
Query: 369 KPLDGFDVWKTISEGSPSPRIELLHNIDPNFVDSSPCPRNSMAPA-KDDSSLPEYSAFNT 427
+ +DG ++ + + E L + ++ + + A K P++ T
Sbjct: 400 RVIDGQNLMPLLEGRASHSDHEFLFHYCGVYLHTVRWHQKDCATVWKAHYVTPKFYPEGT 459
Query: 428 SVHAAIRHGNWKLLTGYPGCGYWFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDL 487
+G C ++ DPP LFDI RDP E L
Sbjct: 460 GACYG---------SGICSCS-----------GDVTYHDPPL----LFDISRDPSEALPL 495
Query: 488 SRE----YPHIVTKLLSRLQFYHKHSVPVYFPAQDPRCDPKATGVWGPWM 533
+ + + ++ K+ + ++ + + PV P+ +W PW+
Sbjct: 496 NPDNEPLFDSVIKKMEAAIREHRRTLTPV------PQQFSVFNTIWKPWL 539
>gi|146229327 arylsulfatase A isoform b [Homo sapiens]
Length = 423
Score = 84.0 bits (206), Expect = 3e-16
Identities = 105/406 (25%), Positives = 153/406 (37%), Gaps = 76/406 (18%)
Query: 108 GLQHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGKWHLGMYRKEC-LPTRRGFDTYF 166
G+ ++ P +PL+E + ++L GY T M GKWHLG+ + LP +GF +
Sbjct: 2 GMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFLPPHQGFHRFL 61
Query: 167 GYLLGSEDYYSHER--CTLIDALN-VTRCA---------------LDFRDGEEVATGYKN 208
G YSH++ C + T C L G +
Sbjct: 62 GIP------YSHDQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWLPGLEA 115
Query: 209 MYSTNIFTKRAIALITNHPPEKPLFLYLALQSVHEPLQVPEEYLKPYDFIQDKNRHHYAG 268
Y A A ++P FLY A H P F + R +
Sbjct: 116 RYMAFAHDLMADA----QRQDRPFFLYYASHHTHYP------QFSGQSFAERSGRGPFGD 165
Query: 269 MVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTL---AGGNNWPLRGRKWSLWEGG 325
+ +D AVG + A+ GL T+ IF+ DNG +T+ GG + LR K + +EGG
Sbjct: 166 SLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGGCSGLLRCGKGTTYEGG 225
Query: 326 VRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSP 385
VR P GV EL D LPTL LA G LDGFD+ +
Sbjct: 226 VREPALAFWPGHIAPGV-THELASSLDLLPTLAALA-GAPLPNVTLDGFDLSPLLLGTGK 283
Query: 386 SPRIELLHNIDPNFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHA--AIRHGNWKLLTG 443
SPR SL Y ++ V A+R G +K
Sbjct: 284 SPR----------------------------QSLFFYPSYPDEVRGVFAVRTGKYKAHFF 315
Query: 444 YPGCGY--WFPPPSQYNVSEIPSSDPPTKTLWLFDIDRDPEERHDL 487
G + P+ + S + + +PP L+D+ +DP E ++L
Sbjct: 316 TQGSAHSDTTADPACHASSSLTAHEPPL----LYDLSKDPGENYNL 357
>gi|4506919 N-sulfoglucosamine sulfohydrolase precursor [Homo
sapiens]
Length = 502
Score = 79.7 bits (195), Expect = 6e-15
Identities = 89/334 (26%), Positives = 133/334 (39%), Gaps = 90/334 (26%)
Query: 21 PVVLPLLLLLLLAPPGSGAGASRPPHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGV 80
PV LLL+L G +RP + + LLADD G+ ++ S I TPHLDALA +
Sbjct: 4 PVPACCALLLVL-----GLCRARPRNALLLLADDGGFESGAYNNSAIATPHLDALARRSL 58
Query: 81 LLDNYYTQ-PLCTPSRSQLLTGRYQIRTGLQ--HQIIWPCQPSCVPLDE-KLLPQLLKEA 136
L N +T C+PSR+ LLTG Q + G+ HQ + D+ + LP LL +A
Sbjct: 59 LFRNAFTSVSSCSPSRASLLTGLPQHQNGMYGLHQDVHHFN----SFDKVRSLPLLLSQA 114
Query: 137 GYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLID-ALNVTRCALD 195
G T ++GK H+G +T + + + Y+ E +++ N+TR
Sbjct: 115 GVRTGIIGKKHVGP------------ETVYPF----DFAYTEENGSVLQVGRNITR---- 154
Query: 196 FRDGEEVATGYKNMYSTNIFTKRAIALITNHPPEKPLFLYLALQSVH------------- 242
K + ++P FLY+A H
Sbjct: 155 --------------------IKLLVRKFLQTQDDRPFFLYVAFHDPHRCGHSQPQYGTFC 194
Query: 243 ---------------------EPLQVPEEYLKPYDFIQDKNRHHYAGMVSLMDEAVGNVT 281
+PL V Y P + V MD+ VG V
Sbjct: 195 EKFGNGESGMGRIPDWTPQAYDPLDVLVPYFVPNTPAARADLAAQYTTVGRMDQGVGLVL 254
Query: 282 AALKSSGLWNNTVFIFSTDNGGQTLAGGNN--WP 313
L+ +G+ N+T+ IF++DNG +G N WP
Sbjct: 255 QELRDAGVLNDTLVIFTSDNGIPFPSGRTNLYWP 288
>gi|4557659 iduronate-2-sulfatase isoform a precursor [Homo sapiens]
Length = 550
Score = 68.2 bits (165), Expect = 2e-11
Identities = 99/406 (24%), Positives = 155/406 (38%), Gaps = 89/406 (21%)
Query: 46 HLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYTQP-LCTPSRSQLLTGRY 103
+++ ++ DDL +G +G + +R+P++D LA+ +L N + Q +C PSR LTGR
Sbjct: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
Query: 104 QIRTGL-QHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGK-WHLGMYRKECLPTRRG 161
T L W + +PQ KE GY T VGK +H G+ +
Sbjct: 97 PDTTRLYDFNSYWRVHAG----NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152
Query: 162 FDTYFGYLLGSEDYYSHERCTLIDA-LNVT-RCALDFRDGEEVATGYKNMYSTNIFTKRA 219
+ ++ Y SE Y + + C D L+ C +D D E K T++A
Sbjct: 153 W-SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQS------TEQA 205
Query: 220 IALITN-HPPEKPLFLYLALQSVHEPLQVPEEYLK------------------------- 253
I L+ P FL + H P + P+E+ K
Sbjct: 206 IQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYN 265
Query: 254 -----------------------PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLW 290
P DF Q K R Y VS +D VG + +AL L
Sbjct: 266 PWMDIRQREDVQALNISVPYGPIPVDF-QRKIRQSYFASVSYLDTQVGRLLSALDDLQLA 324
Query: 291 NNTVFIFSTDNGGQTLAGGNNWP----------------LRGRKWSLWEGGVRGVGFV-- 332
N+T+ F++D+ G L W + GR SL E G + ++
Sbjct: 325 NSTIIAFTSDH-GWALGEHGEWAKYSNFDVATHVPLIFYVPGRTASLPEAGEKLFPYLDP 383
Query: 333 --ASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDV 376
++ L + G ++ +L+ + PTL LA P+ F V
Sbjct: 384 FDSASQLMEPGRQSMDLVELVSLFPTLAGLAGLQVPPRCPVPSFHV 429
>gi|5360208 iduronate-2-sulfatase isoform b precursor [Homo sapiens]
Length = 343
Score = 64.3 bits (155), Expect = 3e-10
Identities = 80/312 (25%), Positives = 123/312 (39%), Gaps = 68/312 (21%)
Query: 46 HLVFLLADDLGWNDVGFHGSR-IRTPHLDALAAGGVLLDNYYTQP-LCTPSRSQLLTGRY 103
+++ ++ DDL +G +G + +R+P++D LA+ +L N + Q +C PSR LTGR
Sbjct: 38 NVLLIIVDDLR-PSLGCYGDKLVRSPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRR 96
Query: 104 QIRTGL-QHQIIWPCQPSCVPLDEKLLPQLLKEAGYTTHMVGK-WHLGMYRKECLPTRRG 161
T L W + +PQ KE GY T VGK +H G+ +
Sbjct: 97 PDTTRLYDFNSYWRVHAG----NFSTIPQYFKENGYVTMSVGKVFHPGISSNHTDDSPYS 152
Query: 162 FDTYFGYLLGSEDYYSHERCTLIDA-LNVT-RCALDFRDGEEVATGYKNMYSTNIFTKRA 219
+ ++ Y SE Y + + C D L+ C +D D E K T++A
Sbjct: 153 W-SFPPYHPSSEKYENTKTCRGPDGELHANLLCPVDVLDVPEGTLPDKQS------TEQA 205
Query: 220 IALITN-HPPEKPLFLYLALQSVHEPLQVPEEYLK------------------------- 253
I L+ P FL + H P + P+E+ K
Sbjct: 206 IQLLEKMKTSASPFFLAVGYHKPHIPFRYPKEFQKLYPLENITLAPDPEVPDGLPPVAYN 265
Query: 254 -----------------------PYDFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLW 290
P DF Q K R Y VS +D VG + +AL L
Sbjct: 266 PWMDIRQREDVQALNISVPYGPIPVDF-QRKIRQSYFASVSYLDTQVGRLLSALDDLQLA 324
Query: 291 NNTVFIFSTDNG 302
N+T+ F++D+G
Sbjct: 325 NSTIIAFTSDHG 336
>gi|240255483 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 56.2 bits (134), Expect = 7e-08
Identities = 92/429 (21%), Positives = 165/429 (38%), Gaps = 84/429 (19%)
Query: 45 PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGV-LLDNYYTQPLCTPSRSQLLTGRY 103
P+++ +L DD DV ++ + GG ++ + T P+C PSRS +LTG+Y
Sbjct: 44 PNIILVLTDD---QDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKY 100
Query: 104 QIRTGLQHQIIWPCQPSCVPLDE-KLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGF 162
PS E + L GY T GK +L Y +P G+
Sbjct: 101 VHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGK-YLNEYNGSYVPP--GW 157
Query: 163 DTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDG--EEVATGYKNMYSTNIFTKRAI 220
+ G L S Y N T C R+G E+ + Y Y T++ T ++
Sbjct: 158 KEWVGLLKNSRFY------------NYTLC----RNGVKEKHGSDYSKDYLTDLITNDSV 201
Query: 221 ALITNHP---PEKPLFLYLALQSVHEPLQVPEEYLK-----------PYDFIQDKNRH-- 264
+ P +P+ + ++ + H P +Y + Y++ + ++H
Sbjct: 202 SFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWI 261
Query: 265 -HYAG-----------------MVSLM--DEAVGNVTAALKSSGLWNNTVFIFSTDNG-- 302
Y G + +LM D+++ + L +G +NT +++ D+G
Sbjct: 262 MRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYH 321
Query: 303 -GQ-TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
GQ L G + P +E +R +V P + + G N ++ D PT++ +
Sbjct: 322 IGQFGLVKGKSMP--------YEFDIRVPFYVRGPNV-EAGCLNPHIVLNIDLAPTILDI 372
Query: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNI----DPNFVDSSPCPR---NSMAPA 413
A + +DG + K + P R L + D V+ N A
Sbjct: 373 A--GLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLLHKRDNDKVDA 430
Query: 414 KDDSSLPEY 422
++++ LP+Y
Sbjct: 431 QEENFLPKY 439
>gi|240255478 sulfatase 2 isoform b precursor [Homo sapiens]
Length = 867
Score = 56.2 bits (134), Expect = 7e-08
Identities = 92/429 (21%), Positives = 165/429 (38%), Gaps = 84/429 (19%)
Query: 45 PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGV-LLDNYYTQPLCTPSRSQLLTGRY 103
P+++ +L DD DV ++ + GG ++ + T P+C PSRS +LTG+Y
Sbjct: 44 PNIILVLTDD---QDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKY 100
Query: 104 QIRTGLQHQIIWPCQPSCVPLDE-KLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGF 162
PS E + L GY T GK +L Y +P G+
Sbjct: 101 VHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGK-YLNEYNGSYVPP--GW 157
Query: 163 DTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDG--EEVATGYKNMYSTNIFTKRAI 220
+ G L S Y N T C R+G E+ + Y Y T++ T ++
Sbjct: 158 KEWVGLLKNSRFY------------NYTLC----RNGVKEKHGSDYSKDYLTDLITNDSV 201
Query: 221 ALITNHP---PEKPLFLYLALQSVHEPLQVPEEYLK-----------PYDFIQDKNRH-- 264
+ P +P+ + ++ + H P +Y + Y++ + ++H
Sbjct: 202 SFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWI 261
Query: 265 -HYAG-----------------MVSLM--DEAVGNVTAALKSSGLWNNTVFIFSTDNG-- 302
Y G + +LM D+++ + L +G +NT +++ D+G
Sbjct: 262 MRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYH 321
Query: 303 -GQ-TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
GQ L G + P +E +R +V P + + G N ++ D PT++ +
Sbjct: 322 IGQFGLVKGKSMP--------YEFDIRVPFYVRGPNV-EAGCLNPHIVLNIDLAPTILDI 372
Query: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNI----DPNFVDSSPCPR---NSMAPA 413
A + +DG + K + P R L + D V+ N A
Sbjct: 373 A--GLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLLHKRDNDKVDA 430
Query: 414 KDDSSLPEY 422
++++ LP+Y
Sbjct: 431 QEENFLPKY 439
>gi|29789100 sulfatase 2 isoform a precursor [Homo sapiens]
Length = 870
Score = 56.2 bits (134), Expect = 7e-08
Identities = 92/429 (21%), Positives = 165/429 (38%), Gaps = 84/429 (19%)
Query: 45 PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGV-LLDNYYTQPLCTPSRSQLLTGRY 103
P+++ +L DD DV ++ + GG ++ + T P+C PSRS +LTG+Y
Sbjct: 44 PNIILVLTDD---QDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCPSRSSILTGKY 100
Query: 104 QIRTGLQHQIIWPCQPSCVPLDE-KLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGF 162
PS E + L GY T GK +L Y +P G+
Sbjct: 101 VHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGK-YLNEYNGSYVPP--GW 157
Query: 163 DTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDG--EEVATGYKNMYSTNIFTKRAI 220
+ G L S Y N T C R+G E+ + Y Y T++ T ++
Sbjct: 158 KEWVGLLKNSRFY------------NYTLC----RNGVKEKHGSDYSKDYLTDLITNDSV 201
Query: 221 ALITNHP---PEKPLFLYLALQSVHEPLQVPEEYLK-----------PYDFIQDKNRH-- 264
+ P +P+ + ++ + H P +Y + Y++ + ++H
Sbjct: 202 SFFRTSKKMYPHRPVLMVISHAAPHGPEDSAPQYSRLFPNASQHITPSYNYAPNPDKHWI 261
Query: 265 -HYAG-----------------MVSLM--DEAVGNVTAALKSSGLWNNTVFIFSTDNG-- 302
Y G + +LM D+++ + L +G +NT +++ D+G
Sbjct: 262 MRYTGPMKPIHMEFTNMLQRKRLQTLMSVDDSMETIYNMLVETGELDNTYIVYTADHGYH 321
Query: 303 -GQ-TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKL 360
GQ L G + P +E +R +V P + + G N ++ D PT++ +
Sbjct: 322 IGQFGLVKGKSMP--------YEFDIRVPFYVRGPNV-EAGCLNPHIVLNIDLAPTILDI 372
Query: 361 ARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNI----DPNFVDSSPCPR---NSMAPA 413
A + +DG + K + P R L + D V+ N A
Sbjct: 373 A--GLDIPADMDGKSILKLLDTERPVNRFHLKKKMRVWRDSFLVERGKLLHKRDNDKVDA 430
Query: 414 KDDSSLPEY 422
++++ LP+Y
Sbjct: 431 QEENFLPKY 439
>gi|189571643 sulfatase 1 [Homo sapiens]
Length = 871
Score = 55.1 bits (131), Expect = 2e-07
Identities = 85/386 (22%), Positives = 149/386 (38%), Gaps = 73/386 (18%)
Query: 45 PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDN-YYTQPLCTPSRSQLLTGRY 103
P+++ +L DD DV ++ + GG N + T P+C PSRS +LTG+Y
Sbjct: 43 PNIILVLTDD---QDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
Query: 104 QIRTGLQHQIIWPCQPSCVPLDE-KLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGF 162
+ PS + E + L GY T GK+ L Y +P G+
Sbjct: 100 VHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--GW 156
Query: 163 DTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAI-- 220
+ G + S Y N T C + E+ Y Y T++ T +I
Sbjct: 157 REWLGLIKNSRFY------------NYTVCRNGIK--EKHGFDYAKDYFTDLITNESINY 202
Query: 221 -ALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK-----------PYDFIQDKNRH---H 265
+ P +P+ + ++ + H P ++ K Y++ + ++H
Sbjct: 203 FKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQ 262
Query: 266 YAG-----------------MVSLM--DEAVGNVTAALKSSGLWNNTVFIFSTDNG---G 303
Y G + +LM D++V + L +G NT I++ D+G G
Sbjct: 263 YTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIG 322
Query: 304 Q-TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLAR 362
Q L G + P ++ +R F+ P ++ + + +++I D PT++ +A
Sbjct: 323 QFGLVKGKSMP--------YDFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
Query: 363 GHTNGTKPLDGFDVWKTISEGSPSPR 388
T +DG V K + P R
Sbjct: 374 LDT--PPDVDGKSVLKLLDPEKPGNR 397
>gi|189571641 sulfatase 1 [Homo sapiens]
Length = 871
Score = 55.1 bits (131), Expect = 2e-07
Identities = 85/386 (22%), Positives = 149/386 (38%), Gaps = 73/386 (18%)
Query: 45 PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDN-YYTQPLCTPSRSQLLTGRY 103
P+++ +L DD DV ++ + GG N + T P+C PSRS +LTG+Y
Sbjct: 43 PNIILVLTDD---QDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
Query: 104 QIRTGLQHQIIWPCQPSCVPLDE-KLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGF 162
+ PS + E + L GY T GK+ L Y +P G+
Sbjct: 100 VHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--GW 156
Query: 163 DTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAI-- 220
+ G + S Y N T C + E+ Y Y T++ T +I
Sbjct: 157 REWLGLIKNSRFY------------NYTVCRNGIK--EKHGFDYAKDYFTDLITNESINY 202
Query: 221 -ALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK-----------PYDFIQDKNRH---H 265
+ P +P+ + ++ + H P ++ K Y++ + ++H
Sbjct: 203 FKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQ 262
Query: 266 YAG-----------------MVSLM--DEAVGNVTAALKSSGLWNNTVFIFSTDNG---G 303
Y G + +LM D++V + L +G NT I++ D+G G
Sbjct: 263 YTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIG 322
Query: 304 Q-TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLAR 362
Q L G + P ++ +R F+ P ++ + + +++I D PT++ +A
Sbjct: 323 QFGLVKGKSMP--------YDFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
Query: 363 GHTNGTKPLDGFDVWKTISEGSPSPR 388
T +DG V K + P R
Sbjct: 374 LDT--PPDVDGKSVLKLLDPEKPGNR 397
>gi|189571638 sulfatase 1 [Homo sapiens]
Length = 871
Score = 55.1 bits (131), Expect = 2e-07
Identities = 85/386 (22%), Positives = 149/386 (38%), Gaps = 73/386 (18%)
Query: 45 PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDN-YYTQPLCTPSRSQLLTGRY 103
P+++ +L DD DV ++ + GG N + T P+C PSRS +LTG+Y
Sbjct: 43 PNIILVLTDD---QDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
Query: 104 QIRTGLQHQIIWPCQPSCVPLDE-KLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGF 162
+ PS + E + L GY T GK+ L Y +P G+
Sbjct: 100 VHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--GW 156
Query: 163 DTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAI-- 220
+ G + S Y N T C + E+ Y Y T++ T +I
Sbjct: 157 REWLGLIKNSRFY------------NYTVCRNGIK--EKHGFDYAKDYFTDLITNESINY 202
Query: 221 -ALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK-----------PYDFIQDKNRH---H 265
+ P +P+ + ++ + H P ++ K Y++ + ++H
Sbjct: 203 FKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQ 262
Query: 266 YAG-----------------MVSLM--DEAVGNVTAALKSSGLWNNTVFIFSTDNG---G 303
Y G + +LM D++V + L +G NT I++ D+G G
Sbjct: 263 YTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIG 322
Query: 304 Q-TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLAR 362
Q L G + P ++ +R F+ P ++ + + +++I D PT++ +A
Sbjct: 323 QFGLVKGKSMP--------YDFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
Query: 363 GHTNGTKPLDGFDVWKTISEGSPSPR 388
T +DG V K + P R
Sbjct: 374 LDT--PPDVDGKSVLKLLDPEKPGNR 397
>gi|189571636 sulfatase 1 [Homo sapiens]
Length = 871
Score = 55.1 bits (131), Expect = 2e-07
Identities = 85/386 (22%), Positives = 149/386 (38%), Gaps = 73/386 (18%)
Query: 45 PHLVFLLADDLGWNDVGFHGSRIRTPHLDALAAGGVLLDN-YYTQPLCTPSRSQLLTGRY 103
P+++ +L DD DV ++ + GG N + T P+C PSRS +LTG+Y
Sbjct: 43 PNIILVLTDD---QDVELGSLQVMNKTRKIMEHGGATFINAFVTTPMCCPSRSSMLTGKY 99
Query: 104 QIRTGLQHQIIWPCQPSCVPLDE-KLLPQLLKEAGYTTHMVGKWHLGMYRKECLPTRRGF 162
+ PS + E + L GY T GK+ L Y +P G+
Sbjct: 100 VHNHNVYTNNENCSSPSWQAMHEPRTFAVYLNNTGYRTAFFGKY-LNEYNGSYIPP--GW 156
Query: 163 DTYFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAI-- 220
+ G + S Y N T C + E+ Y Y T++ T +I
Sbjct: 157 REWLGLIKNSRFY------------NYTVCRNGIK--EKHGFDYAKDYFTDLITNESINY 202
Query: 221 -ALITNHPPEKPLFLYLALQSVHEPLQVPEEYLK-----------PYDFIQDKNRH---H 265
+ P +P+ + ++ + H P ++ K Y++ + ++H
Sbjct: 203 FKMSKRMYPHRPVMMVISHAAPHGPEDSAPQFSKLYPNASQHITPSYNYAPNMDKHWIMQ 262
Query: 266 YAG-----------------MVSLM--DEAVGNVTAALKSSGLWNNTVFIFSTDNG---G 303
Y G + +LM D++V + L +G NT I++ D+G G
Sbjct: 263 YTGPMLPIHMEFTNILQRKRLQTLMSVDDSVERLYNMLVETGELENTYIIYTADHGYHIG 322
Query: 304 Q-TLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLAR 362
Q L G + P ++ +R F+ P ++ + + +++I D PT++ +A
Sbjct: 323 QFGLVKGKSMP--------YDFDIRVPFFIRGPSVEPGSIVPQIVLNI-DLAPTILDIAG 373
Query: 363 GHTNGTKPLDGFDVWKTISEGSPSPR 388
T +DG V K + P R
Sbjct: 374 LDT--PPDVDGKSVLKLLDPEKPGNR 397
>gi|4504061 glucosamine (N-acetyl)-6-sulfatase precursor [Homo
sapiens]
Length = 552
Score = 51.6 bits (122), Expect = 2e-06
Identities = 99/426 (23%), Positives = 164/426 (38%), Gaps = 91/426 (21%)
Query: 9 LPRGPG------PRRLLLPVVLPLLLLLLLAPP----GSGAGASRPPHLVFLLADDLGWN 58
LP PG PR L P P LLLL+L G AG RP ++V LL DD
Sbjct: 4 LPLAPGRLRRGSPRHL--PSCSPALLLLVLGGCLGVFGVAAGTRRP-NVVLLLTDD---Q 57
Query: 59 DVGFHGSRIRTPHLDALAAGGVLLDNYYT-QPLCTPSRSQLLTGRYQIRTGLQHQIIWPC 117
D G + G+ + Y LC PSR+ +LTG+Y H +
Sbjct: 58 DEVLGGMTPLKKTKALIGEMGMTFSSAYVPSALCCPSRASILTGKYPHN---HHVVNNTL 114
Query: 118 QPSCVP------LDEKLLPQLLKE-AGYTTHMVGKWHLGMYRKECLPTRRGFD------T 164
+ +C + P +L+ GY T GK +L Y P G + +
Sbjct: 115 EGNCSSKSWQKIQEPNTFPAILRSMCGYQTFFAGK-YLNEYG---APDAGGLEHVPLGWS 170
Query: 165 YFGYLLGSEDYYSHERCTLIDALNVTRCALDFRDGEEVATGYKNMYSTNIFTKRAIALIT 224
Y+ L + YY++ L++ A + GE Y Y T++ ++ +
Sbjct: 171 YWYALEKNSKYYNY-------TLSINGKAR--KHGE----NYSVDYLTDVLANVSLDFLD 217
Query: 225 NHPPEKPLFLYLALQSVHEPLQVPEEYLKPY----------------------------- 255
+P F+ +A + H P +Y K +
Sbjct: 218 YKSNFEPFFMMIATPAPHSPWTAAPQYQKAFQNVFAPRNKNFNIHGTNKHWLIRQAKTPM 277
Query: 256 -----DFIQDKNRHHYAGMVSLMDEAVGNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGN 310
F+ + R + ++S +D+ V + L+ +G NNT +++DNG T G
Sbjct: 278 TNSSIQFLDNAFRKRWQTLLS-VDDLVEKLVKRLEFTGELNNTYIFYTSDNGYHT--GQF 334
Query: 311 NWPLRGRKWSLWEGGVRGVGFVASPLLKQKGVKNRELIHISDWLPTLVKLARGHTNGTKP 370
+ P+ R+ L+E ++ V P +K ++ L+ D PT++ +A N T+
Sbjct: 335 SLPIDKRQ--LYEFDIKVPLLVRGPGIKPNQT-SKMLVANIDLGPTILDIAGYDLNKTQ- 390
Query: 371 LDGFDV 376
+DG +
Sbjct: 391 MDGMSL 396
>gi|169217295 PREDICTED: similar to iduronate 2-sulfatase (Hunter
syndrome) [Homo sapiens]
Length = 142
Score = 42.7 bits (99), Expect = 8e-04
Identities = 28/81 (34%), Positives = 38/81 (46%), Gaps = 6/81 (7%)
Query: 67 IRTPHLDALAAGGVLLDNYYTQP-LCTPSRSQLLTGRYQIRTGL-QHQIIWPCQPSCVPL 124
++ P++D LA+ +L N + Q +C PSR LTGR T L W
Sbjct: 22 VKAPNIDQLASHSLLFQNAFAQQAVCAPSRVSFLTGRRPDTTRLYDFNSYWRVHAG---- 77
Query: 125 DEKLLPQLLKEAGYTTHMVGK 145
+ +PQ KE GY T VGK
Sbjct: 78 NFSTIPQYFKENGYVTMSVGK 98
>gi|39930577 arylsulfatase K [Homo sapiens]
Length = 536
Score = 41.6 bits (96), Expect = 0.002
Identities = 107/526 (20%), Positives = 191/526 (36%), Gaps = 101/526 (19%)
Query: 18 LLLPVVLPLLLLLLLAPPGSGAG---ASRPPHLVFLLADDLGWNDVGFHGSRI-RTPHLD 73
LLL V + L L + PG+G A++ P++V +++D GS++ + P ++
Sbjct: 2 LLLWVSVVAALALAVLAPGAGEQRRRAAKAPNVVLVVSDSFDGRLTFHPGSQVVKLPFIN 61
Query: 74 ALAAGGVLLDNYYTQ-PLCTPSRSQLLTGRYQIRTGLQHQIIWPCQPSCVPLDEKLLPQL 132
+ G N YT P+C PSR+ + +G + T W P + +
Sbjct: 62 FMKTRGTSFLNAYTNSPICCPSRAAMWSGLFTHLTE-----SWNNFKGLDP-NYTTWMDV 115
Query: 133 LKEAGYTTHMVGKWHLGMYRKECLPTRRGFDTYFGYLLGSEDYYSHERCTLIDALNVTRC 192
++ GY T GK + +LL E LI N T+
Sbjct: 116 MERHGYRTQKFGKLDYTSGHHSISNRVEAWTRDVAFLLRQE---GRPMVNLI--RNRTKV 170
Query: 193 ALDFRDGE--EVATGYKNMYSTNIFTKRAIALITN--HPPEKP------------LFLYL 236
+ RD + + A + + N I L N HP P LY
Sbjct: 171 RVMERDWQNTDKAVNWLRKEAINYTEPFVIYLGLNLPHPYPSPSSGENFGSSTFHTSLYW 230
Query: 237 ALQSVHEPLQVPE----EYLKPYDFIQD--KN-------------RHHYAGMVSLMDEAV 277
+ H+ +++P+ + P D+ KN R Y M + D +
Sbjct: 231 LEKVSHDAIKIPKWSPLSEMHPVDYYSSYTKNCTGRFTKKEIKNIRAFYYAMCAETDAML 290
Query: 278 GNVTAALKSSGLWNNTVFIFSTDNGGQTLAGGNNWPLRGRKWSLWEGGVRGVGFVASPLL 337
G + AL L T+ I+S+D+G + + K S++E + P +
Sbjct: 291 GEIILALHQLDLLQKTIVIYSSDHGELAMEHRQFY-----KMSMYEASAHVPLLMMGPGI 345
Query: 338 KQKGVKNRELIHISDWLPTLVKLARGHTNGTKPLDGFDVWKTISEGSPSPRIELLHNIDP 397
K G++ ++ + D PT++ +A + L G+ + SE + + N+ P
Sbjct: 346 K-AGLQVSNVVSLVDIYPTMLDIA--GIPLPQNLSGYSLLPLSSETFKNE--HKVKNLHP 400
Query: 398 NFVDSSPCPRNSMAPAKDDSSLPEYSAFNTSVHA-AIRHGNWKLLTGYPGCGYWFPPPSQ 456
++ L E+ N + +R +WK + G
Sbjct: 401 PWI------------------LSEFHGCNVNASTYMLRTNHWKYIAYSDG---------- 432
Query: 457 YNVSEIPSSDPPTKTLWLFDIDRDPEERHDLSREYPHIVTKLLSRL 502
S +P LFD+ DP+E +++ ++P I L +L
Sbjct: 433 --ASILPQ---------LFDLSSDPDELTNVAVKFPEITYSLDQKL 467
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.139 0.454
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,267,883
Number of Sequences: 37866
Number of extensions: 1328400
Number of successful extensions: 3704
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 24
Number of HSP's that attempted gapping in prelim test: 3547
Number of HSP's gapped (non-prelim): 95
length of query: 533
length of database: 18,247,518
effective HSP length: 107
effective length of query: 426
effective length of database: 14,195,856
effective search space: 6047434656
effective search space used: 6047434656
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.