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Search of human proteins with 38194229
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38194229 kelch-like 17 [Homo sapiens]
(642 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38194229 kelch-like 17 [Homo sapiens] 1298 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 541 e-154
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 528 e-150
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 526 e-149
gi|166235129 kelch-like 3 [Homo sapiens] 516 e-146
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 474 e-133
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 474 e-133
gi|55925604 kelch-like 18 [Homo sapiens] 472 e-133
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 467 e-131
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 456 e-128
gi|14780904 kelch-like 1 protein [Homo sapiens] 451 e-126
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 445 e-125
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 444 e-124
gi|11056006 kelch-like 12 [Homo sapiens] 429 e-120
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 419 e-117
gi|34101268 kelch-like 8 [Homo sapiens] 399 e-111
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 373 e-103
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 373 e-103
gi|148664209 kelch-like 10 [Homo sapiens] 346 4e-95
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 332 8e-91
gi|223890235 intracisternal A particle-promoted polypeptide isof... 310 2e-84
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 292 6e-79
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 290 2e-78
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 290 2e-78
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 287 2e-77
gi|40018614 DRE1 protein [Homo sapiens] 280 3e-75
gi|55925608 kelch-like 21 [Homo sapiens] 275 9e-74
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 258 1e-68
gi|24308181 kelch-like 9 [Homo sapiens] 255 1e-67
gi|45643138 kelch-like 13 [Homo sapiens] 254 2e-67
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 1298 bits (3360), Expect = 0.0
Identities = 642/642 (100%), Positives = 642/642 (100%)
Query: 1 MQPRSERPAGRTQSPEHGSPGPGPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLL 60
MQPRSERPAGRTQSPEHGSPGPGPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLL
Sbjct: 1 MQPRSERPAGRTQSPEHGSPGPGPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLL 60
Query: 61 SREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAM 120
SREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAM
Sbjct: 61 SREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAM 120
Query: 121 FTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDA 180
FTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDA
Sbjct: 121 FTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDA 180
Query: 181 CCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLE 240
CCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLE
Sbjct: 181 CCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLE 240
Query: 241 LVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESL 300
LVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESL
Sbjct: 241 LVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESL 300
Query: 301 VRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCE 360
VRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCE
Sbjct: 301 VRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCE 360
Query: 361 AYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEV 420
AYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEV
Sbjct: 361 AYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEV 420
Query: 421 SMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVAT 480
SMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVAT
Sbjct: 421 SMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVAT 480
Query: 481 LDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDG 540
LDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDG
Sbjct: 481 LDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDG 540
Query: 541 TSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPR 600
TSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPR
Sbjct: 541 TSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPR 600
Query: 601 TNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL 642
TNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL
Sbjct: 601 TNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTSL 642
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 541 bits (1393), Expect = e-154
Identities = 277/555 (49%), Positives = 374/555 (67%), Gaps = 1/555 (0%)
Query: 71 SKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQ 130
S +H ++ +R+ LCD+VL V AK+I AH+V+L++CSPYF AMFT E++ESRQ
Sbjct: 47 SDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQ 106
Query: 131 THVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLD 190
T V + DID +A++ L+ FAYT++I V EGNVQTLLPAA LLQL +++ACC+FL QLD
Sbjct: 107 TEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLD 166
Query: 191 PSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVP 250
PSNCLGIR FAD HSC +LL+ A ++ +F +V ++EEFMLLP Q+++++SSD LNV
Sbjct: 167 PSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVR 226
Query: 251 SEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDL 310
SEE+V+ AV++WVK+ + RR +P++++ VRLPLLS FL+G V ++ L++ +C+DL
Sbjct: 227 SEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDL 286
Query: 311 LIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWH 370
+ EA + LLP++R ++ RTRPR+ G VLFAVGG E YD +T+ W
Sbjct: 287 VDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWR 346
Query: 371 VVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVS-MGTRRSCL 429
+VASMS RR VGV+ + + LYAVGG+DG+S L +VE YDP TN W +V+ T R+ +
Sbjct: 347 MVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSV 406
Query: 430 GVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVG 489
GVA L G LY+ GG DG SCLN ERYDP WT VA+MSTRR V VA L G LYAVG
Sbjct: 407 GVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVG 466
Query: 490 GYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVER 549
G D +S L TVE+Y PQ N W +A M +RR G AV + +Y GG D T+ L+S ER
Sbjct: 467 GSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAER 526
Query: 550 YSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASC 609
Y+P+ W V M RRS L ++G L AVGG DG++ L +IE ++P N W
Sbjct: 527 YNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGG 586
Query: 610 MFTRRSSVGVAVLEL 624
M RR GV V+++
Sbjct: 587 MNYRRLGGGVGVIKM 601
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 528 bits (1359), Expect = e-150
Identities = 285/597 (47%), Positives = 378/597 (63%), Gaps = 14/597 (2%)
Query: 31 PPQPPAPEAERTRPRQARPAAPMEGAVQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGL 90
PP PPA T+ +P + + E H + H AF M+ +R + L
Sbjct: 4 PPLPPAC----TKQGHQKPLDSKDD-----NTEKHCPVTVNPWHMKKAFKVMNELRSQNL 54
Query: 91 LCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFA 150
LCD+ + EI AH+VVLA+CSPYFHAMFT EMSESR V + ++D L L+ +
Sbjct: 55 LCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYV 114
Query: 151 YTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLL 210
YTAEI V E NVQ LLPAA LLQL V+ CC+FL SQL P NCLGIR FAD H+C+DLL
Sbjct: 115 YTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLL 174
Query: 211 KAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDAR 270
A+ Y QHF DV +EEF+ L ++QV L+SSD L + SEE+V+ AV++WV HD D R
Sbjct: 175 NKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVR 234
Query: 271 RQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP-EQRGVLGT 329
++ + RLM+ VRLPLL R++L+ V+ E+LV++ CKD LIEA+K+HLLP EQR ++ +
Sbjct: 235 QEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKS 294
Query: 330 SRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGN 389
RTR R ++ VGG + AI E YD + +RWH VA + +RR R G+ +
Sbjct: 295 VRTRLRTPMNLPKLMVVVGGQAPKAIR-SVECYDFKEERWHQVAELPSRRCRAGMVYMAG 353
Query: 390 RLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASC 449
++AVGG++G+ + TV+SYDPV + W +M RRS LG A L+GLLY+ GG+DG++
Sbjct: 354 LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG 413
Query: 450 LNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSH--LATVEKYEPQV 507
L+S E Y+ + W VA M+TRR V V + G LYAVGGYD +S L+TVE Y
Sbjct: 414 LSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATT 473
Query: 508 NVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRR 567
N W+ +A M +RRS AGV VL LY GG+DG SVE Y P AW VA MN+ R
Sbjct: 474 NEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCR 533
Query: 568 STHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW-VAASCMFTRRSSVGVAVLE 623
+ A++G LY VGG+DGS +L S+E YNP T+KW V +SCM T RS GV V++
Sbjct: 534 RNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVID 590
Score = 144 bits (363), Expect = 2e-34
Identities = 80/185 (43%), Positives = 110/185 (59%), Gaps = 2/185 (1%)
Query: 443 GYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK 502
G + S E YD W VA + +RR + + G ++AVGG++ S + TV+
Sbjct: 313 GGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDS 372
Query: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAP 562
Y+P + W+ VA+M RRS+ G AVL G LY GG DG++ L+SVE Y+ K+ W VAP
Sbjct: 373 YDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAP 432
Query: 563 MNIRRSTHDLVAMDGWLYAVGGNDGSSS--LNSIEKYNPRTNKWVAASCMFTRRSSVGVA 620
MN RRS+ + + G LYAVGG DG+S L+++E YN TN+W + M TRRS GV
Sbjct: 433 MNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVG 492
Query: 621 VLELL 625
VL L
Sbjct: 493 VLNNL 497
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 526 bits (1355), Expect = e-149
Identities = 276/554 (49%), Positives = 364/554 (65%), Gaps = 5/554 (0%)
Query: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
H AF M+ +R + LLCD+ + EI AH+VVLA+CSPYFHAMFT EMSESR V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
+ ++D L L+ + YTAEI V E NVQ LLPAA LLQL V+ CC+FL SQL P N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
CLGIR FAD H+C+DLL A+ Y QHF DV +EEF+ L ++QV L+SSD L + SEE
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
+V+ AV++WV HD D R++ + RLM+ VRLPLL R++L+ V+ E+LV++ CKD LIE
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 314 ALKFHLLP-EQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVV 372
A+K+HLLP EQR ++ + RTR R ++ VGG + AI E YD + +RWH V
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIR-SVECYDFKEERWHQV 340
Query: 373 ASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVA 432
A + +RR R G+ + ++AVGG++G+ + TV+SYDPV + W +M RRS LG A
Sbjct: 341 AELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAA 400
Query: 433 ALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYD 492
L+GLLY+ GG+DG++ L+S E Y+ + W VA M+TRR V V + G LYAVGGYD
Sbjct: 401 VLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYD 460
Query: 493 SSSH--LATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERY 550
+S L+TVE Y N W+ +A M +RRS AGV VL LY GG+DG SVE Y
Sbjct: 461 GASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVY 520
Query: 551 SPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW-VAASC 609
P AW VA MN+ R + A++G LY VGG+DGS +L S+E YNP T+KW V +SC
Sbjct: 521 DPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSC 580
Query: 610 MFTRRSSVGVAVLE 623
M T RS GV V++
Sbjct: 581 MSTGRSYAGVTVID 594
Score = 144 bits (363), Expect = 2e-34
Identities = 80/185 (43%), Positives = 110/185 (59%), Gaps = 2/185 (1%)
Query: 443 GYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK 502
G + S E YD W VA + +RR + + G ++AVGG++ S + TV+
Sbjct: 317 GGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDS 376
Query: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAP 562
Y+P + W+ VA+M RRS+ G AVL G LY GG DG++ L+SVE Y+ K+ W VAP
Sbjct: 377 YDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAP 436
Query: 563 MNIRRSTHDLVAMDGWLYAVGGNDGSSS--LNSIEKYNPRTNKWVAASCMFTRRSSVGVA 620
MN RRS+ + + G LYAVGG DG+S L+++E YN TN+W + M TRRS GV
Sbjct: 437 MNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVG 496
Query: 621 VLELL 625
VL L
Sbjct: 497 VLNNL 501
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 516 bits (1329), Expect = e-146
Identities = 274/553 (49%), Positives = 361/553 (65%), Gaps = 5/553 (0%)
Query: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
H AF M+ +R + LLCD+++ EI AH+VVLA+CSPYF AMFT +MSES+ +
Sbjct: 32 HMGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKI 91
Query: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
+ D+D Q L +L+ + YTAEI V E NVQ LLPAASLLQL VR CC FL SQL P+N
Sbjct: 92 EIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTN 151
Query: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
CLGIR FAD H+C+DLL+ A+ Y QHF +V EEF+ L L QV L+SSD L V SEE
Sbjct: 152 CLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEE 211
Query: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
+V+ AV+SW+ ++ + R +H+ +LM+ VRLPLL RD+L+ V+ E+L++++ CKD LIE
Sbjct: 212 KVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIE 271
Query: 314 ALKFHLLP-EQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVV 372
A+K+HLLP +QR ++ RT+PR V+ VGG + AI E YD DRW +
Sbjct: 272 AMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIR-SVECYDFEEDRWDQI 330
Query: 373 ASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVA 432
A + +RR R GV + +YAVGG++G+ + TV+ YD V + W SM RRS LG A
Sbjct: 331 AELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAA 390
Query: 433 ALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYD 492
L+ LLY+ GG+DG++ L S E Y T W VA M+TRR V V ++G LYAVGGYD
Sbjct: 391 VLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYD 450
Query: 493 SSSH--LATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERY 550
+S L+TVE+Y P N W VA M +RRS AGV VL G LY GG+DG SVE Y
Sbjct: 451 GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVY 510
Query: 551 SPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW-VAASC 609
P W+ VA MN+ R + A++G LY VGG+DGS +L S+E YNP T+KW + +
Sbjct: 511 DPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTN 570
Query: 610 MFTRRSSVGVAVL 622
M T RS GVAV+
Sbjct: 571 MSTGRSYAGVAVI 583
Score = 102 bits (253), Expect = 1e-21
Identities = 56/139 (40%), Positives = 82/139 (58%), Gaps = 1/139 (0%)
Query: 485 LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCL 544
+ VGG + + +VE Y+ + + W +A + SRR AGV + G +Y GG +G+ +
Sbjct: 303 MIVVGG-QAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRV 361
Query: 545 NSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW 604
+V+ Y W S+A M RRST ++ LYAVGG DGS+ L S+E Y+ +TN+W
Sbjct: 362 RTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEW 421
Query: 605 VAASCMFTRRSSVGVAVLE 623
+ M TRRSSVGV V+E
Sbjct: 422 FFVAPMNTRRSSVGVGVVE 440
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 474 bits (1220), Expect = e-133
Identities = 247/557 (44%), Positives = 346/557 (62%), Gaps = 9/557 (1%)
Query: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
H F M + LCD++L + I AH++VL+S S YF AMFTN++ E+RQ +
Sbjct: 156 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 215
Query: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
+ ++P +L L+Q+AYT + + E N++ LL A LLQL+ V +ACCKFL+ QL PSN
Sbjct: 216 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 275
Query: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
CLGIR FADA C+DL K AH Y ++HF++V + +EF+LLP ++ +L++SD +N+P+EE
Sbjct: 276 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 335
Query: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
+ A+L+WV+HD++ RR+ + +L+ +RLPLL+ F L ++ L R +C+ L++E
Sbjct: 336 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQF-LADMENNVLFRDDIECQKLIME 394
Query: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVA 373
A+K+HLLPE+R +L + RT+PR+ LFAVGG E YD RT+ W VA
Sbjct: 395 AMKYHLLPERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA 452
Query: 374 SMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAA 433
+M+ RR + GVA + ++LY VGG DG L TVE Y+P T TW M T R LGVA
Sbjct: 453 NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAV 512
Query: 434 LHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDS 493
L G +Y+ GG+DG S LN+ ER+DP W VA MST R V VA L G LYAVGG D
Sbjct: 513 LEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDG 572
Query: 494 SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDG-----TSCLNS-V 547
SS L +VE ++P N W+ A M RR GV G LY GG+D TS L+ V
Sbjct: 573 SSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCV 632
Query: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAA 607
ERY PK W +VA M+I R + + LYAVGG DG + LN++E Y+P+TN+W
Sbjct: 633 ERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQV 692
Query: 608 SCMFTRRSSVGVAVLEL 624
+ + R+ V ++L
Sbjct: 693 APLCLGRAGACVVTVKL 709
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 474 bits (1220), Expect = e-133
Identities = 247/557 (44%), Positives = 346/557 (62%), Gaps = 9/557 (1%)
Query: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
H F M + LCD++L + I AH++VL+S S YF AMFTN++ E+RQ +
Sbjct: 202 HAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEI 261
Query: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
+ ++P +L L+Q+AYT + + E N++ LL A LLQL+ V +ACCKFL+ QL PSN
Sbjct: 262 KMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSN 321
Query: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
CLGIR FADA C+DL K AH Y ++HF++V + +EF+LLP ++ +L++SD +N+P+EE
Sbjct: 322 CLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEE 381
Query: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
+ A+L+WV+HD++ RR+ + +L+ +RLPLL+ F L ++ L R +C+ L++E
Sbjct: 382 TILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQF-LADMENNVLFRDDIECQKLIME 440
Query: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVA 373
A+K+HLLPE+R +L + RT+PR+ LFAVGG E YD RT+ W VA
Sbjct: 441 AMKYHLLPERRPMLQSPRTKPRK--STVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVA 498
Query: 374 SMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAA 433
+M+ RR + GVA + ++LY VGG DG L TVE Y+P T TW M T R LGVA
Sbjct: 499 NMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAV 558
Query: 434 LHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDS 493
L G +Y+ GG+DG S LN+ ER+DP W VA MST R V VA L G LYAVGG D
Sbjct: 559 LEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDG 618
Query: 494 SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDG-----TSCLNS-V 547
SS L +VE ++P N W+ A M RR GV G LY GG+D TS L+ V
Sbjct: 619 SSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCV 678
Query: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAA 607
ERY PK W +VA M+I R + + LYAVGG DG + LN++E Y+P+TN+W
Sbjct: 679 ERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQV 738
Query: 608 SCMFTRRSSVGVAVLEL 624
+ + R+ V ++L
Sbjct: 739 APLCLGRAGACVVTVKL 755
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 472 bits (1214), Expect = e-133
Identities = 248/573 (43%), Positives = 340/573 (59%), Gaps = 5/573 (0%)
Query: 54 EGAVQLLSREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASC 113
+GA +L SV+ R Y M +R++G LCD+ L + + AH++VLA+
Sbjct: 4 DGAEELEDLVHFSVSELPSRGYG----VMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAAS 59
Query: 114 SPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQ 173
PYFHAMFTN+M E +Q + + +DP AL+ L+ FAY + + + NVQ+LL AS LQ
Sbjct: 60 IPYFHAMFTNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQ 119
Query: 174 LNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLL 233
L ++DACC FL +L P NCLG+R FA+ C+ L AA+ ++ QHFV+V+ +EEF+ L
Sbjct: 120 LQSIKDACCTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLAL 179
Query: 234 PLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLG 293
PL+ VLELVS D LNV SEE+V+ A L+WV++D + R ++P L+ +RLPL FL
Sbjct: 180 PLEDVLELVSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSD 239
Query: 294 HVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG-GSL 352
V + LVR C+DL+ EA +HL+PE+R L RTRPR C +++AVGG S
Sbjct: 240 RVQQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSA 299
Query: 353 FAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPV 412
E +D + W M+T R+RVGVA V LYA+GGYDG L+TVE+Y+P
Sbjct: 300 GDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPE 359
Query: 413 TNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTR 472
T+TW SM ++RS +G L G +Y GGYDG S L+S E Y P T WT V +MS+
Sbjct: 360 TDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSN 419
Query: 473 RRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGAL 532
R V +G +Y GG+D ++VE Y W P A ML++R G A L +
Sbjct: 420 RSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKM 479
Query: 533 YVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLN 592
+V GG DG+ L+ E YS A W + PM+ RRS LVA G LYAVGG DG S+L+
Sbjct: 480 FVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLS 539
Query: 593 SIEKYNPRTNKWVAASCMFTRRSSVGVAVLELL 625
S+E Y+P T+ W + M VGV + LL
Sbjct: 540 SVEMYDPETDCWTFMAPMACHEGGVGVGCIPLL 572
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 467 bits (1202), Expect = e-131
Identities = 248/503 (49%), Positives = 329/503 (65%), Gaps = 5/503 (0%)
Query: 125 MSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKF 184
MSESR V + ++D L L+ + YTAEI V E NVQ LLPAA LLQL V+ CC+F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 185 LLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSS 244
L SQL P NCLGIR FAD H+C+DLL A+ Y QHF DV +EEF+ L ++QV L+SS
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 245 DSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHH 304
D L + SEE+V+ AV++WV HD D R++ + RLM+ VRLPLL R++L+ V+ E+LV++
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 305 PDCKDLLIEALKFHLLP-EQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYD 363
CKD LIEA+K+HLLP EQR ++ + RTR R ++ VGG + AI E YD
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIR-SVECYD 239
Query: 364 TRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMG 423
+ +RWH VA + +RR R G+ + ++AVGG++G+ + TV+SYDPV + W +M
Sbjct: 240 FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMR 299
Query: 424 TRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDG 483
RRS LG A L+GLLY+ GG+DG++ L+S E Y+ + W VA M+TRR V V + G
Sbjct: 300 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 359
Query: 484 NLYAVGGYDSSSH--LATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGT 541
LYAVGGYD +S L+TVE Y N W+ +A M +RRS AGV VL LY GG+DG
Sbjct: 360 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGP 419
Query: 542 SCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRT 601
SVE Y P AW VA MN+ R + A++G LY VGG+DGS +L S+E YNP T
Sbjct: 420 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTT 479
Query: 602 NKW-VAASCMFTRRSSVGVAVLE 623
+KW V +SCM T RS GV V++
Sbjct: 480 DKWTVVSSCMSTGRSYAGVTVID 502
Score = 144 bits (363), Expect = 2e-34
Identities = 80/185 (43%), Positives = 110/185 (59%), Gaps = 2/185 (1%)
Query: 443 GYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK 502
G + S E YD W VA + +RR + + G ++AVGG++ S + TV+
Sbjct: 225 GGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDS 284
Query: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAP 562
Y+P + W+ VA+M RRS+ G AVL G LY GG DG++ L+SVE Y+ K+ W VAP
Sbjct: 285 YDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAP 344
Query: 563 MNIRRSTHDLVAMDGWLYAVGGNDGSSS--LNSIEKYNPRTNKWVAASCMFTRRSSVGVA 620
MN RRS+ + + G LYAVGG DG+S L+++E YN TN+W + M TRRS GV
Sbjct: 345 MNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVG 404
Query: 621 VLELL 625
VL L
Sbjct: 405 VLNNL 409
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 456 bits (1172), Expect = e-128
Identities = 237/524 (45%), Positives = 332/524 (63%), Gaps = 9/524 (1%)
Query: 107 KVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLL 166
++VL+S S YF AMFTN++ E+RQ + + ++P +L L+Q+AYT + + E N++ LL
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 167 PAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAK 226
A LLQL+ V +ACCKFL+ QL PSNCLGIR FADA C+DL K AH Y ++HF++V +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 227 TEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLL 286
+EF+LLP ++ +L++SD +N+P+EE + A+L+WV+HD++ RR+ + +L+ +RLPLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 287 SRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFA 346
+ F L ++ L R +C+ L++EA+K+HLLPE+R +L + RT+PR+ LFA
Sbjct: 354 APQF-LADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRK--STVGTLFA 410
Query: 347 VGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATV 406
VGG E YD RT+ W VA+M+ RR + GVA + ++LY VGG DG L TV
Sbjct: 411 VGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTV 470
Query: 407 ESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSV 466
E Y+P T TW M T R LGVA L G +Y+ GG+DG S LN+ ER+DP W V
Sbjct: 471 ECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFV 530
Query: 467 AAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVA 526
A MST R V VA L G LYAVGG D SS L +VE ++P N W+ A M RR GV
Sbjct: 531 ATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVT 590
Query: 527 VLEGALYVAGGNDG-----TSCLNS-VERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLY 580
G LY GG+D TS L+ VERY PK W +VA M+I R + + LY
Sbjct: 591 TWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLY 650
Query: 581 AVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLEL 624
AVGG DG + LN++E Y+P+TN+W + + R+ V ++L
Sbjct: 651 AVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTVKL 694
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 451 bits (1159), Expect = e-126
Identities = 240/589 (40%), Positives = 352/589 (59%), Gaps = 22/589 (3%)
Query: 54 EGAVQLLSREGHSVAHNSK-------------RHYHDAFVAMSRMRQRGLLCDIVLHVAA 100
EG LS GHS+ S H F M ++ LCD++L V
Sbjct: 161 EGCGHRLSSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGN 220
Query: 101 KEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEG 160
++I AH++VL+S S YF AMFT+++ E++Q + + IDP AL LVQFAYT + + E
Sbjct: 221 RKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKED 280
Query: 161 NVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQH 220
++ LL AA LLQL V + CC FL+ L PSNCLGIR FADA C +L+K AH Y +++
Sbjct: 281 TIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMEN 340
Query: 221 FVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKC 280
++V + +EF+LLP +++ +L++SD +NVP EE ++ A++ WVK+D+ +R + L+
Sbjct: 341 IMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAF 400
Query: 281 VRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGA 340
+RLPLL +L ++ +L ++ +C+ L++EA+K+HLLPE+R ++ + RT+PR+
Sbjct: 401 IRLPLLPPQ-ILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRK--ST 457
Query: 341 GPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGT 400
L+AVGG E YD RT+ W M+ RR + GVA + ++L+ +GG DG
Sbjct: 458 VGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGL 517
Query: 401 SDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLT 460
L TVE Y+P T TW M T R LGV L G +Y+ GG+DG S LN+ ER+DP +
Sbjct: 518 KTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQS 577
Query: 461 GTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRR 520
WT VA+MS R V VA L+G LY+VGG D SS L+++E Y+P N W+ A M RR
Sbjct: 578 QQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRR 637
Query: 521 SSAGVAVLEGALYVAGGNDG------TSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVA 574
GVA +G LY GG+D + L+ VERY PK W VAP+++ R +
Sbjct: 638 GGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCL 697
Query: 575 MDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
+ LYAVGG DG + LN++E Y+P+TN+W + + R+ V V++
Sbjct: 698 LGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIK 746
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 445 bits (1144), Expect = e-125
Identities = 233/557 (41%), Positives = 332/557 (59%), Gaps = 9/557 (1%)
Query: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
H M + LCD++L I AH++VL++ S YF AMFTN++ E++Q V
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
+ +DP AL+ LVQ+AYT + + E +++LL AA LLQL V D C FL+ QL PSN
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
CLGIR F DA C++LL AH+Y ++HF++V K +EF+LLP ++ +L+ SD +NVP EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
++ A++ WV HDV R+ + L+ +RLPLL LL ++ S+ +C+ LL+E
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLME 402
Query: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVA 373
A+K+HLLPE+R ++ + RT+PR+ L+AVGG E YD RT+ W +
Sbjct: 403 AMKYHLLPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
Query: 374 SMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAA 433
+M+ RR + GVA + N+LY VGG DG L TVE ++PV W M T R LGVA
Sbjct: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVAT 520
Query: 434 LHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDS 493
L G +Y+ GG+DG S LN+ ER+DP W VA+MST R V V L+ LYA+GG D
Sbjct: 521 LEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG 580
Query: 494 SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDG------TSCLNSV 547
SS L ++E ++P N WS A M RR GVA G LYV GG+D + + V
Sbjct: 581 SSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCV 640
Query: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAA 607
ERY PK +W +VAP+++ R + + LY VGG DG + LN++E Y+ + N+W
Sbjct: 641 ERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEE 700
Query: 608 SCMFTRRSSVGVAVLEL 624
+ R+ V V++L
Sbjct: 701 VPVNIGRAGACVVVVKL 717
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 444 bits (1141), Expect = e-124
Identities = 229/537 (42%), Positives = 324/537 (60%), Gaps = 9/537 (1%)
Query: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
H M + LCD++L I AH++VL++ S YF AMFTN++ E++Q V
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEV 223
Query: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
+ +DP AL+ LVQ+AYT + + E +++LL AA LLQL V D C FL+ QL PSN
Sbjct: 224 RMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSN 283
Query: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
CLGIR F DA C++LL AH+Y ++HF++V K +EF+LLP ++ +L+ SD +NVP EE
Sbjct: 284 CLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEE 343
Query: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
++ A++ WV HDV R+ + L+ +RLPLL LL ++ S+ +C+ LL+E
Sbjct: 344 TIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLLME 402
Query: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVA 373
A+K+HLLPE+R ++ + RT+PR+ L+AVGG E YD RT+ W +
Sbjct: 403 AMKYHLLPERRSMMQSPRTKPRK--STVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIG 460
Query: 374 SMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAA 433
+M+ RR + GVA + N+LY VGG DG L TVE ++PV W M T R LGVA
Sbjct: 461 TMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVAT 520
Query: 434 LHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDS 493
L G +Y+ GG+DG S LN+ ER+DP W VA+MST R V V L+ LYA+GG D
Sbjct: 521 LEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDG 580
Query: 494 SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDG------TSCLNSV 547
SS L ++E ++P N WS A M RR GVA G LYV GG+D + + V
Sbjct: 581 SSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCV 640
Query: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW 604
ERY PK +W +VAP+++ R + + LY VGG DG + LN++E Y+ + N+W
Sbjct: 641 ERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
Score = 160 bits (406), Expect = 3e-39
Identities = 82/185 (44%), Positives = 108/185 (58%)
Query: 436 GLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSS 495
G LY+ GG D + E+YD T +W + M+ RR VA +D LY VGG D
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 496 HLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAG 555
L TVE + P +W+ + M + R GVA LEG +Y GG+DG S LN+VER+ P+
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGR 548
Query: 556 AWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRS 615
W VA M+ RST +VA++ LYA+GG DGSS L S+E ++P TNKW + M RR
Sbjct: 549 QWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRG 608
Query: 616 SVGVA 620
VGVA
Sbjct: 609 GVGVA 613
Score = 121 bits (304), Expect = 2e-27
Identities = 63/154 (40%), Positives = 92/154 (59%), Gaps = 1/154 (0%)
Query: 469 MSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVL 528
M + R R +T+ G LYAVGG D+ T+EKY+ + N W + +M RR GVAV+
Sbjct: 416 MQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
Query: 529 EGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGS 588
+ LYV GG DG LN+VE ++P W + PM+ R + ++G +YAVGG+DG
Sbjct: 475 DNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGW 534
Query: 589 SSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVL 622
S LN++E+++P +W + M T RS+VGV L
Sbjct: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
Score = 73.9 bits (180), Expect = 4e-13
Identities = 36/94 (38%), Positives = 49/94 (52%)
Query: 530 GALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSS 589
GALY GG D ++E+Y + +W + MN RR + +D LY VGG DG
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 590 SLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
+LN++E +NP W M T R +GVA LE
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
Score = 64.3 bits (155), Expect = 3e-10
Identities = 36/80 (45%), Positives = 45/80 (56%), Gaps = 6/80 (7%)
Query: 344 LFAVGGGSLFAIH-----GDC-EAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGY 397
L+ VGG A + DC E YD + D W VA +S R V V +G++LY VGGY
Sbjct: 619 LYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY 678
Query: 398 DGTSDLATVESYDPVTNTWQ 417
DG + L TVESYD N W+
Sbjct: 679 DGHTYLNTVESYDAQRNEWK 698
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 429 bits (1103), Expect = e-120
Identities = 230/553 (41%), Positives = 326/553 (58%), Gaps = 6/553 (1%)
Query: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
H +M+ +R+ LCD+ L V K+ AH++VLA+CS YF AMFT+E+SE + +V
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
+ + ++ L+ F YT + V NVQ LLPAA LLQL GV+ ACC+FL SQLDPSN
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
CLGIR FA+ H+C DL++AA + +HF +V + EEF+LL +V +L+ D + V SEE
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
Query: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
V+ AV++WVKH R + +P L++ VR+PLL+ ++ +DAE +R C+DL+ E
Sbjct: 195 PVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDE 254
Query: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG-GSLFAIHGDCEAYDTRTDRWHVV 372
A KFHL PE R + RTR R GA VL VGG GS + E YD +T W +
Sbjct: 255 AKKFHLRPELRSQMQGPRTRARL--GANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFL 312
Query: 373 ASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTN---TWQPEVSMGTRRSCL 429
S++ +R V ++ +R+Y +GGYDG S L++VE D + W M RR
Sbjct: 313 PSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLA 372
Query: 430 GVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVG 489
G L ++Y +GG+DG+ S ERYDP W+ + M T R + G +Y +G
Sbjct: 373 GATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLG 432
Query: 490 GYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVER 549
GYD + L +VEKY+P W+ V M ++RS AGVA+L +YV GG DGT+ L+SVE
Sbjct: 433 GYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEA 492
Query: 550 YSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASC 609
Y+ + +W +V M R + G LYA+ G DG+S L+SIE Y+P + W +
Sbjct: 493 YNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTS 552
Query: 610 MFTRRSSVGVAVL 622
M T+R GV VL
Sbjct: 553 MGTQRCDAGVCVL 565
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 419 bits (1076), Expect = e-117
Identities = 235/567 (41%), Positives = 327/567 (57%), Gaps = 12/567 (2%)
Query: 65 HSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNE 124
+ +A+ + H ++ +RQ LCDI+L V +I AHKVVLAS SPYF AMFT
Sbjct: 8 YMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGN 67
Query: 125 MSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKF 184
+SE + V ID AL +V++AYT + + + V++LLPAA+LLQ+ V CC F
Sbjct: 68 LSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAF 127
Query: 185 LLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSS 244
L SQLDP NC+GI FA+ + C DL AA +Y+ Q+F V +TEEF L + E+VS+
Sbjct: 128 LESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSN 187
Query: 245 DSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHH 304
D LNV +EE V+ A+ SW+K+DV R++++ +L+ VRLPLLS FL +A L+R
Sbjct: 188 DCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDD 247
Query: 305 PDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGS-LFAIHGDCEAYD 363
CK LL EALK+H +PE R T RC A VL AVGG S LFA E Y
Sbjct: 248 RTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRC--APKVLCAVGGKSGLFACLDSVEMYF 305
Query: 364 TRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGT--------SDLATVESYDPVTNT 415
+ D W +A ++ R G+ + ++Y +GG +VE ++P TNT
Sbjct: 306 PQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNT 365
Query: 416 WQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRY 475
W M RS LGV L G LY+ GGYDG S L S E+Y P W VA M+T R
Sbjct: 366 WTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSC 425
Query: 476 VRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVA 535
A LDG +YA+GGY +H+ +VE+Y+P + W VASM +R GV V+ G ++V
Sbjct: 426 FAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVV 484
Query: 536 GGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIE 595
GG++G S L+S+ERY P W PM R+ +D +LY VGG+ GSS LN+++
Sbjct: 485 GGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQ 544
Query: 596 KYNPRTNKWVAASCMFTRRSSVGVAVL 622
KY+P ++ W+ ++ M R + G+ L
Sbjct: 545 KYDPISDTWLDSAGMIYCRCNFGLTAL 571
Score = 161 bits (408), Expect = 2e-39
Identities = 96/242 (39%), Positives = 134/242 (55%), Gaps = 10/242 (4%)
Query: 391 LYAVGGYDGT-SDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGY----- 444
L AVGG G + L +VE Y P ++W + R G+ L +Y GG
Sbjct: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
Query: 445 DGASCL---NSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVE 501
G + NS E ++P T TWTS+ M+ R + V L G LYA+GGYD S+L +VE
Sbjct: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404
Query: 502 KYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVA 561
KY P++ W PVA M + RS AVL+G +Y GG G + +NSVERY P +WE VA
Sbjct: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVA 463
Query: 562 PMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAV 621
M +R + M G+++ VGG++G S L+SIE+Y+P N+W M R+ VG AV
Sbjct: 464 SMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAV 523
Query: 622 LE 623
++
Sbjct: 524 ID 525
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 399 bits (1024), Expect = e-111
Identities = 215/555 (38%), Positives = 327/555 (58%), Gaps = 6/555 (1%)
Query: 75 YHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVT 134
+ D ++ R + G LCD+ L V +K I HK+VLA PYF AMF +EM+E++QT +
Sbjct: 50 WKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIE 109
Query: 135 LHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNC 194
+ D D A++ LV+F Y++ + + NVQ LL AA +LQ+ V ACC+++ PSNC
Sbjct: 110 IRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNC 169
Query: 195 LGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEE 254
L +R FA++H+ DL+ A +Y HF +V + E+F+ + + + +L+SS LN+ +E++
Sbjct: 170 LAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQ 229
Query: 255 VYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEA 314
VY A + W+ + + + + VRLPLL DFL+G V E +V+ + C+DLL EA
Sbjct: 230 VYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEA 289
Query: 315 LKFHLLPEQRGVLG---TSRTRPRRCEGAGPVLFAVGG-GSLFAIHGDCEAYDTRTDRWH 370
+HL R V + RT PR+ AG VLF VGG G E Y + W
Sbjct: 290 RNYHLHLSSRAVPDFEYSIRTTPRK-HTAG-VLFCVGGRGGSGDPFRSIECYSINKNSWF 347
Query: 371 VVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLG 430
M++RR VGV +V ++YAVGG+DG L ++E +DP+TN W + SM T+R +
Sbjct: 348 FGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIA 407
Query: 431 VAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGG 490
+A+L G +Y+ GG D +C N ERYD + W++VA M+T R V L ++YAVGG
Sbjct: 408 LASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG 467
Query: 491 YDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERY 550
D + L++VE+Y+P ++ W V M RR+ GV+ L G LYV GG D S L+SVERY
Sbjct: 468 NDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERY 527
Query: 551 SPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCM 610
P++ W+ VA + R + + G ++AVGG++G++ LN++E ++P N+W +
Sbjct: 528 DPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSV 587
Query: 611 FTRRSSVGVAVLELL 625
R+ GVAV L
Sbjct: 588 SHCRAGAGVAVCSCL 602
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 373 bits (958), Expect = e-103
Identities = 218/557 (39%), Positives = 309/557 (55%), Gaps = 16/557 (2%)
Query: 74 HYHDAFVAMSRMRQRGLLCDIVLHVA-----AKEIRAHKVVLASCSPYFHAMFTNEMSES 128
H AF M+ +R LCD+ L V A + AHKVVLAS SP F AMFTN + E
Sbjct: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
Query: 129 RQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188
V++ I P+ +++L++FAYTA I +GE V ++ A + Q++ V AC FL+ Q
Sbjct: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Query: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248
LDPSN +GI FA+ C +L + A Y+ HF +VAK EEF L Q++ L+S D LN
Sbjct: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
Query: 249 VPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCK 308
V E EV+ A ++WVK+D + RR +V L++ VR L+ +FL + +++ CK
Sbjct: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
Query: 309 DLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDR 368
D L++ + L + V+ P R G +++ GG ++ EAY+
Sbjct: 299 DYLVKIFEELTLHKPTQVM------PCRAPKVGRLIYTAGGYFRQSL-SYLEAYNPSDGT 351
Query: 369 WHVVASMSTRRARVGVAAVGNRLYAVGGY----DGTSDLATVESYDPVTNTWQPEVSMGT 424
W +A + R+ + VG LYAVGG DG +D + ++ Y+P+TN W P M
Sbjct: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
Query: 425 RRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGN 484
R+ +GV + G +Y+ GG G NS ERY+P W VA M TRR V VA L+
Sbjct: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 485 LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCL 544
LYAVGG+D ++ L + E Y P+ N W + +M + RS AGV VL +Y AGG DG L
Sbjct: 472 LYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
Query: 545 NSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW 604
NSVERY + W VAPM RRS + G +Y +GG DG + L+S+E Y+P T+ W
Sbjct: 532 NSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
Query: 605 VAASCMFTRRSSVGVAV 621
+ M + RS VGVAV
Sbjct: 592 SEVTRMTSGRSGVGVAV 608
Score = 137 bits (345), Expect = 3e-32
Identities = 79/190 (41%), Positives = 105/190 (55%), Gaps = 5/190 (2%)
Query: 437 LLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGY----D 492
L+Y+AGGY S L+ E Y+P GTW +A + R + + G LYAVGG D
Sbjct: 327 LIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
Query: 493 SSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSP 552
++ + ++ Y P N WSP A M R+ GV V++G +Y GG+ G NSVERY P
Sbjct: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
Query: 553 KAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFT 612
+ W VAPM RR + ++ LYAVGG DG++ LNS E Y P N+W + M T
Sbjct: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNT 505
Query: 613 RRSSVGVAVL 622
RS GV VL
Sbjct: 506 IRSGAGVCVL 515
Score = 96.3 bits (238), Expect = 8e-20
Identities = 53/145 (36%), Positives = 77/145 (53%), Gaps = 5/145 (3%)
Query: 485 LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGN----DG 540
+Y GGY S L+ +E Y P W +A + RS V+ G LY GG DG
Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 541 TSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPR 600
+ ++++ Y+P W APM++ R+ + +DG +YAVGG+ G NS+E+Y P
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 601 TNKWVAASCMFTRRSSVGVAVLELL 625
++W + M TRR VGVAVL L
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRL 471
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 373 bits (958), Expect = e-103
Identities = 218/557 (39%), Positives = 309/557 (55%), Gaps = 16/557 (2%)
Query: 74 HYHDAFVAMSRMRQRGLLCDIVLHVA-----AKEIRAHKVVLASCSPYFHAMFTNEMSES 128
H AF M+ +R LCD+ L V A + AHKVVLAS SP F AMFTN + E
Sbjct: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
Query: 129 RQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188
V++ I P+ +++L++FAYTA I +GE V ++ A + Q++ V AC FL+ Q
Sbjct: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
Query: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248
LDPSN +GI FA+ C +L + A Y+ HF +VAK EEF L Q++ L+S D LN
Sbjct: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
Query: 249 VPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCK 308
V E EV+ A ++WVK+D + RR +V L++ VR L+ +FL + +++ CK
Sbjct: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
Query: 309 DLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDR 368
D L++ + L + V+ P R G +++ GG ++ EAY+
Sbjct: 299 DYLVKIFEELTLHKPTQVM------PCRAPKVGRLIYTAGGYFRQSL-SYLEAYNPSDGT 351
Query: 369 WHVVASMSTRRARVGVAAVGNRLYAVGGY----DGTSDLATVESYDPVTNTWQPEVSMGT 424
W +A + R+ + VG LYAVGG DG +D + ++ Y+P+TN W P M
Sbjct: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
Query: 425 RRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGN 484
R+ +GV + G +Y+ GG G NS ERY+P W VA M TRR V VA L+
Sbjct: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 485 LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCL 544
LYAVGG+D ++ L + E Y P+ N W + +M + RS AGV VL +Y AGG DG L
Sbjct: 472 LYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
Query: 545 NSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW 604
NSVERY + W VAPM RRS + G +Y +GG DG + L+S+E Y+P T+ W
Sbjct: 532 NSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
Query: 605 VAASCMFTRRSSVGVAV 621
+ M + RS VGVAV
Sbjct: 592 SEVTRMTSGRSGVGVAV 608
Score = 137 bits (345), Expect = 3e-32
Identities = 79/190 (41%), Positives = 105/190 (55%), Gaps = 5/190 (2%)
Query: 437 LLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGY----D 492
L+Y+AGGY S L+ E Y+P GTW +A + R + + G LYAVGG D
Sbjct: 327 LIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
Query: 493 SSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSP 552
++ + ++ Y P N WSP A M R+ GV V++G +Y GG+ G NSVERY P
Sbjct: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
Query: 553 KAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFT 612
+ W VAPM RR + ++ LYAVGG DG++ LNS E Y P N+W + M T
Sbjct: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNT 505
Query: 613 RRSSVGVAVL 622
RS GV VL
Sbjct: 506 IRSGAGVCVL 515
Score = 96.3 bits (238), Expect = 8e-20
Identities = 53/145 (36%), Positives = 77/145 (53%), Gaps = 5/145 (3%)
Query: 485 LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGN----DG 540
+Y GGY S L+ +E Y P W +A + RS V+ G LY GG DG
Sbjct: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 541 TSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPR 600
+ ++++ Y+P W APM++ R+ + +DG +YAVGG+ G NS+E+Y P
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 601 TNKWVAASCMFTRRSSVGVAVLELL 625
++W + M TRR VGVAVL L
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRL 471
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 346 bits (887), Expect = 4e-95
Identities = 187/543 (34%), Positives = 291/543 (53%), Gaps = 3/543 (0%)
Query: 83 SRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQA 142
+ +R G LCD+V+ V E AHK +L SCS YF A+FT+ + + + + I P
Sbjct: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDM 89
Query: 143 LDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFAD 202
+ ++++AYT + + NV+ LL AA + G+ CC+FL S+L NC+GI F D
Sbjct: 90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTD 149
Query: 203 AHSCSDLLKAAHRYVLQHFVDVAKTE-EFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLS 261
+ C +L + A+ ++L +F ++ K EF+ L + ++ +++ D LNV E+ V+ A+L
Sbjct: 150 YYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILK 209
Query: 262 WVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP 321
W+ HD R+QH+ L+ VRL L+ ++ + +V V+ +CK ++I ALK
Sbjct: 210 WISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDL 269
Query: 322 EQRGVLGTSRTRP-RRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRW-HVVASMSTRR 379
G + T P R +LFA+GG S + EAYD R DRW +V + R
Sbjct: 270 NMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPR 329
Query: 380 ARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLY 439
A G A + +Y +GG+D +V+ +DPV TW M +RR + V L +Y
Sbjct: 330 AYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIY 389
Query: 440 SAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLAT 499
+ GG+DG LN+AERY+P T WT +A M +R TL G +Y GG++ + L T
Sbjct: 390 AMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFT 449
Query: 500 VEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWES 559
E Y + N W+ +A M SRRS GV +Y GG DG + L S E YSP A W +
Sbjct: 450 AEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRT 509
Query: 560 VAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGV 619
+ M RS + +D L+ VGG +G ++ ++E Y+ +T++W A M RS++
Sbjct: 510 IPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSC 569
Query: 620 AVL 622
V+
Sbjct: 570 CVV 572
Score = 53.9 bits (128), Expect = 4e-07
Identities = 30/97 (30%), Positives = 44/97 (45%)
Query: 341 GPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGT 400
G ++AVGG EAY + W + +M R+ G+ V + L+ VGG++G
Sbjct: 479 GEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGF 538
Query: 401 SDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGL 437
+ VE YD T+ W M RS L + GL
Sbjct: 539 TTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGL 575
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 332 bits (850), Expect = 8e-91
Identities = 198/574 (34%), Positives = 301/574 (52%), Gaps = 25/574 (4%)
Query: 70 NSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESR 129
+S +H +++MR CD+ L V + +AH++VLA+ SPYF A+FT M ES
Sbjct: 15 SSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESS 74
Query: 130 QTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 189
+ V + I+ L+ F YT + +G NVQ L+ AA +LQL V CC+FL Q+
Sbjct: 75 KDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQI 134
Query: 190 DPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNV 249
DP NC+GI F++ +C DLL+ + Y+ HF++V EEF+ L Q+++++ S+ L++
Sbjct: 135 DPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSI 194
Query: 250 PSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKD 309
E +V+ A + W+ D+ RR+HV ++ +R PLL LL +++ S +
Sbjct: 195 EDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQT 254
Query: 310 LLIEALKFHLLPEQR---GVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGD-------- 358
LL E + P++ L TS+ RPR+ A L+AVGG + + G
Sbjct: 255 LLKEYCEVCKSPKENKFCSFLQTSKVRPRK--KARKYLYAVGGYT--RLQGGRWSDSRAL 310
Query: 359 --CEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTW 416
E +DT + W V+S+ R+ +GV +G +YA+GG + E YDPVT W
Sbjct: 311 SCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQW 370
Query: 417 QPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYV 476
SM R LGV +G +Y+ GG+ GA N+ ER+DP W V M+ R Y
Sbjct: 371 TTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYF 430
Query: 477 RVATLDGNLYAVGGYDSSS-HLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVA 535
+ G +Y +GG + L + E Y+P WSP+ M +RR+ GVA L +Y
Sbjct: 431 GCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSV 490
Query: 536 GG-NDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGS------ 588
GG N+ L++VE+YS + W VA M + R+ +VA++G LY GG S
Sbjct: 491 GGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAP 550
Query: 589 SSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVL 622
+L+S+E YNP ++ W M T R GVAVL
Sbjct: 551 GTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
Score = 81.6 bits (200), Expect = 2e-15
Identities = 49/147 (33%), Positives = 70/147 (47%), Gaps = 8/147 (5%)
Query: 485 LYAVGGY--------DSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAG 536
LYAVGGY S L+ VE+++ W+ V+S+ RS GV VL G +Y G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 537 GNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEK 596
G + + E Y P W +VA MN R + G +YA+GG G+ N+IE+
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
Query: 597 YNPRTNKWVAASCMFTRRSSVGVAVLE 623
++P NKW M R G ++
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQ 436
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 310 bits (795), Expect = 2e-84
Identities = 188/572 (32%), Positives = 291/572 (50%), Gaps = 21/572 (3%)
Query: 70 NSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESR 129
+S +H +++MR CD+ L V + +AH++VLA+ SPYF A+FT M ES
Sbjct: 15 SSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESS 74
Query: 130 QTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 189
+ V + I+ L+ F YT + +G NVQ L+ AA +LQL V CC+FL Q+
Sbjct: 75 KDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQI 134
Query: 190 DPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNV 249
DP NC+GI F++ +C DLL+ + Y+ HF++V EEF+ L Q+++++ S+ L++
Sbjct: 135 DPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSI 194
Query: 250 PSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKD 309
E +V+ A + W+ D+ RR+HV ++ +R PLL LL +++ S +
Sbjct: 195 EDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQT 254
Query: 310 LLIEALKFHLLPEQR---GVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGD-------- 358
LL E + P++ L TS+ RPR+ A L+AVGG + + G
Sbjct: 255 LLKEYCEVCKSPKENKFCSFLQTSKVRPRK--KARKYLYAVGGYT--RLQGGRWSDSRAL 310
Query: 359 --CEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTW 416
E +DT + W V+S+ R+ +GV +G +YA+GG + E YDPVT W
Sbjct: 311 SCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQW 370
Query: 417 QPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYV 476
SM R LGV +G +Y+ GG+ GA N+ ER+DP W V M+ R Y
Sbjct: 371 TTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYF 430
Query: 477 RVATLDGNLYAVGGYDSSS-HLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVA 535
+ G +Y +GG + L + E Y+P WSP+ M +RR+ GVA L +Y
Sbjct: 431 GCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSV 490
Query: 536 GG-NDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSL--N 592
GG N+ L++VE+YS + W VA M + R+ +VA++G LY GG S
Sbjct: 491 GGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAP 550
Query: 593 SIEKYNPRTNKWVAASCMFTRRSSVGVAVLEL 624
+Y KW +F ++ + L
Sbjct: 551 DTHRYEVFRLKWENMCILFNDHKTLTKGIFNL 582
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 292 bits (748), Expect = 6e-79
Identities = 181/525 (34%), Positives = 269/525 (51%), Gaps = 52/525 (9%)
Query: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141
M+ MR++ LCD++L V ++I AH+VVLA+ S +F+ MFT M ES+ V L D +P
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
Query: 142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFA 201
++QLV+FAYTA I V NVQ+LL AA+ Q+ V+ C FL Q+D SNCLGI A
Sbjct: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
Query: 202 DAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLS 261
+ C +L A ++ QHF +V KT+EF+ L +K+V L++ D+L V +E++VY A +
Sbjct: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
Query: 262 WVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLL- 320
W+K+D R+ + ++ VR PL+S++FL V AE L++ +P+C ++I +++HLL
Sbjct: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
Query: 321 PEQRGVLGTSRTRPRR-----------------CEGAGP--------------------- 342
PE R L TRPRR C P
Sbjct: 274 PEDREEL-VDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACV 332
Query: 343 ----VLFAVGGGSLFAI-HGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGY 397
V++ +GG LF I DC Y+ D W+ T R + A ++Y GG
Sbjct: 333 FWDNVVYILGGSQLFPIKRMDC--YNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGS 390
Query: 398 D-GTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDG----ASCLNS 452
+ G S L E YD T +W + SM T+R G+ +GL+Y GG G LNS
Sbjct: 391 EVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNS 450
Query: 453 AERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSP 512
E YDP T TWT + M R+ + + ++AVGG + L VE Y+ ++N W
Sbjct: 451 CEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKM 510
Query: 513 VASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAW 557
V+ M + + A + +YV G G L + Y+ + W
Sbjct: 511 VSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
Score = 70.9 bits (172), Expect = 4e-12
Identities = 49/186 (26%), Positives = 81/186 (43%), Gaps = 12/186 (6%)
Query: 446 GASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK--- 502
G S S ++P +WT + +RR D +Y +GG S L +++
Sbjct: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG----SQLFPIKRMDC 354
Query: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGND-GTSCLNSVERYSPKAGAWESVA 561
Y + W + R S EG +Y +GG++ G S L E Y + +W +
Sbjct: 355 YNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKP 414
Query: 562 PMNIRRSTHDLVAMDGWLYAVGGNDGSSS----LNSIEKYNPRTNKWVAASCMFTRRSSV 617
M +R +H +V +G +Y GG+ G++ LNS E Y+P T W M R +
Sbjct: 415 SMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNH 474
Query: 618 GVAVLE 623
G+ ++
Sbjct: 475 GLVFVK 480
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 290 bits (743), Expect = 2e-78
Identities = 182/596 (30%), Positives = 274/596 (45%), Gaps = 18/596 (3%)
Query: 23 GPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLLSREG-HSVAHNSKRHYHDAFVA 81
GP PPPPP QP A P +Q+L G H +
Sbjct: 259 GPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKE 318
Query: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQ-----THVTLH 136
+++ R+ D+ + V +E H+ VLASCS YF + + +S Q + L
Sbjct: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
Query: 137 DIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLG 196
++ L+ L++F YT +V+ N +TLL AAS Q + C FL QL SNCLG
Sbjct: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Query: 197 IRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVY 256
+ A+A CS+L A + LQ F +VA EE + + + VS+DSLN +EE VY
Sbjct: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
Query: 257 RAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALK 316
V+ W+K D R Q+ L+ VRLP + +LL VD E L++ C+DL+ EA +
Sbjct: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
Query: 317 FHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHG----DCEAYDTRTDRWHVV 372
+H+LP R + T RTRPR G V+ VGG + + ++ + ++W+ +
Sbjct: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
Query: 373 ASMS-TRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGV 431
AS+ R V + G+ +Y GG + LA V Y + + W M R
Sbjct: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
Query: 432 AALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGY 491
G +Y+ GG A ++ ERYD +T W +VA + G +Y GG
Sbjct: 679 LVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV 738
Query: 492 DSSSHLATV-EKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERY 550
+ + A V + Y PQ N WS + S + A L G +++ GG + + Y
Sbjct: 739 NEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----AYARATTIY 794
Query: 551 SPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG--NDGSSSLNSIEKYNPRTNKW 604
P+ G ++ MN R V +DG +YA GG + +L ++E Y P TN W
Sbjct: 795 DPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTW 850
Score = 75.9 bits (185), Expect = 1e-13
Identities = 53/177 (29%), Positives = 77/177 (43%), Gaps = 9/177 (5%)
Query: 344 LFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDL 403
++ +GG + E YDT T++W VA + G ++Y GG +
Sbjct: 685 IYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRA 744
Query: 404 ATV-ESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGG-YDGASCLNSAERYDPLTG 461
A V +SY P TNTW S L+G ++ GG Y A+ + YDP G
Sbjct: 745 AGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTI-----YDPEKG 799
Query: 462 TWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSH--LATVEKYEPQVNVWSPVASM 516
+ M+ R++ LDG +YA GG SS L +E YEP N W+ + M
Sbjct: 800 NIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHM 856
Score = 63.2 bits (152), Expect = 7e-10
Identities = 47/164 (28%), Positives = 72/164 (43%), Gaps = 7/164 (4%)
Query: 450 LNSAERYDPLTGTWTSVAAMSTRRRY----VRVATLDGNLYAVGGYDSSSHLATVEKYEP 505
+N A+RY L + TR R V L G VG S L V + P
Sbjct: 553 VNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRS--LVAVTCWNP 610
Query: 506 QVNVWSPVASM-LSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMN 564
Q N W P+AS+ R V +Y++GG + L V Y W V+ M
Sbjct: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
Query: 565 IRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAAS 608
+ R H+ + DG +Y +GG + +++ +E+Y+ TN+W A +
Sbjct: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVA 714
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 290 bits (743), Expect = 2e-78
Identities = 182/596 (30%), Positives = 274/596 (45%), Gaps = 18/596 (3%)
Query: 23 GPEAPPPPPPQPPAPEAERTRPRQARPAAPMEGAVQLLSREG-HSVAHNSKRHYHDAFVA 81
GP PPPPP QP A P +Q+L G H +
Sbjct: 259 GPLLPPPPPAQPSATLPSGAPATNGPPTTDSAHGLQMLRTIGVGKYEFTDPGHPREMLKE 318
Query: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQ-----THVTLH 136
+++ R+ D+ + V +E H+ VLASCS YF + + +S Q + L
Sbjct: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
Query: 137 DIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLG 196
++ L+ L++F YT +V+ N +TLL AAS Q + C FL QL SNCLG
Sbjct: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Query: 197 IRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVY 256
+ A+A CS+L A + LQ F +VA EE + + + VS+DSLN +EE VY
Sbjct: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
Query: 257 RAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALK 316
V+ W+K D R Q+ L+ VRLP + +LL VD E L++ C+DL+ EA +
Sbjct: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
Query: 317 FHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHG----DCEAYDTRTDRWHVV 372
+H+LP R + T RTRPR G V+ VGG + + ++ + ++W+ +
Sbjct: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
Query: 373 ASMS-TRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGV 431
AS+ R V + G+ +Y GG + LA V Y + + W M R
Sbjct: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
Query: 432 AALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGY 491
G +Y+ GG A ++ ERYD +T W +VA + G +Y GG
Sbjct: 679 LVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV 738
Query: 492 DSSSHLATV-EKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERY 550
+ + A V + Y PQ N WS + S + A L G +++ GG + + Y
Sbjct: 739 NEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----AYARATTIY 794
Query: 551 SPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG--NDGSSSLNSIEKYNPRTNKW 604
P+ G ++ MN R V +DG +YA GG + +L ++E Y P TN W
Sbjct: 795 DPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTW 850
Score = 75.9 bits (185), Expect = 1e-13
Identities = 53/177 (29%), Positives = 77/177 (43%), Gaps = 9/177 (5%)
Query: 344 LFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDL 403
++ +GG + E YDT T++W VA + G ++Y GG +
Sbjct: 685 IYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRA 744
Query: 404 ATV-ESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGG-YDGASCLNSAERYDPLTG 461
A V +SY P TNTW S L+G ++ GG Y A+ + YDP G
Sbjct: 745 AGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYARATTI-----YDPEKG 799
Query: 462 TWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSH--LATVEKYEPQVNVWSPVASM 516
+ M+ R++ LDG +YA GG SS L +E YEP N W+ + M
Sbjct: 800 NIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLLPHM 856
Score = 63.2 bits (152), Expect = 7e-10
Identities = 47/164 (28%), Positives = 72/164 (43%), Gaps = 7/164 (4%)
Query: 450 LNSAERYDPLTGTWTSVAAMSTRRRY----VRVATLDGNLYAVGGYDSSSHLATVEKYEP 505
+N A+RY L + TR R V L G VG S L V + P
Sbjct: 553 VNEAKRYHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRS--LVAVTCWNP 610
Query: 506 QVNVWSPVASM-LSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMN 564
Q N W P+AS+ R V +Y++GG + L V Y W V+ M
Sbjct: 611 QNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMT 670
Query: 565 IRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAAS 608
+ R H+ + DG +Y +GG + +++ +E+Y+ TN+W A +
Sbjct: 671 VPRCRHNSLVYDGKIYTLGGLGVAGNVDHVERYDTITNQWEAVA 714
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 287 bits (735), Expect = 2e-77
Identities = 179/524 (34%), Positives = 266/524 (50%), Gaps = 52/524 (9%)
Query: 83 SRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQA 142
S + + LCD++L V ++I AH+VVLA+ S +F+ MFT M ES+ V L D +P
Sbjct: 13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 72
Query: 143 LDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFAD 202
++QLV+FAYTA I V NVQ+LL AA+ Q+ V+ C FL Q+D SNCLGI A+
Sbjct: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
Query: 203 AHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLSW 262
C +L A ++ QHF +V KT+EF+ L +K+V L++ D+L V +E++VY A + W
Sbjct: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
Query: 263 VKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLL-P 321
+K+D R+ + ++ VR PL+S++FL V AE L++ +P+C ++I +++HLL P
Sbjct: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
Query: 322 EQRGVLGTSRTRPRR-----------------CEGAGP---------------------- 342
E R L TRPRR C P
Sbjct: 253 EDREEL-VDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVF 311
Query: 343 ---VLFAVGGGSLFAI-HGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYD 398
V++ +GG LF I DC Y+ D W+ T R + A ++Y GG +
Sbjct: 312 WDNVVYILGGSQLFPIKRMDC--YNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSE 369
Query: 399 -GTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDG----ASCLNSA 453
G S L E YD T +W + SM T+R G+ +GL+Y GG G LNS
Sbjct: 370 VGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSC 429
Query: 454 ERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPV 513
E YDP T TWT + M R+ + + ++AVGG + L VE Y+ ++N W V
Sbjct: 430 EVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMV 489
Query: 514 ASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAW 557
+ M + + A + +YV G G L + Y+ + W
Sbjct: 490 SPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
Score = 70.9 bits (172), Expect = 4e-12
Identities = 49/186 (26%), Positives = 81/186 (43%), Gaps = 12/186 (6%)
Query: 446 GASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK--- 502
G S S ++P +WT + +RR D +Y +GG S L +++
Sbjct: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG----SQLFPIKRMDC 332
Query: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGND-GTSCLNSVERYSPKAGAWESVA 561
Y + W + R S EG +Y +GG++ G S L E Y + +W +
Sbjct: 333 YNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKP 392
Query: 562 PMNIRRSTHDLVAMDGWLYAVGGNDGSSS----LNSIEKYNPRTNKWVAASCMFTRRSSV 617
M +R +H +V +G +Y GG+ G++ LNS E Y+P T W M R +
Sbjct: 393 SMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNH 452
Query: 618 GVAVLE 623
G+ ++
Sbjct: 453 GLVFVK 458
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 280 bits (716), Expect = 3e-75
Identities = 175/536 (32%), Positives = 272/536 (50%), Gaps = 20/536 (3%)
Query: 74 HYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
H + + R L D+++ V KE H+ VL++CS YF AMF N+ ESR+ V
Sbjct: 48 HAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLV 107
Query: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
++ I +A++ +Q+ YT ++ + NVQ L +SL Q++ +RDAC KFL QLDP N
Sbjct: 108 EINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCN 167
Query: 194 CLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEE 253
CLGI+ FAD HS L + LQ F DV++ EEF+ L ++++ + SD L + EE
Sbjct: 168 CLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEE 227
Query: 254 EVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIE 313
V+ AV+ WV VD RR + L+ VRLPLL ++ + V+ + L+++ P+C LL E
Sbjct: 228 MVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHE 287
Query: 314 ALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG----GSLFAIHGDCEAYDTRTDRW 369
A ++H+L + + + RTRPRR G V+ VGG G + +C YD T W
Sbjct: 288 ARRYHILGNE---MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTEC--YDPVTGEW 342
Query: 370 HVVASM-STRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSC 428
+A + ++ V A+ N + GG + D V Y+ N W S+ R
Sbjct: 343 KSLAKLPEFTKSEYAVCALRNDILVSGGRINSRD---VWIYNSQLNIWIRVASLNKGRWR 399
Query: 429 LGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAV 488
+A L G +Y GGYDG + L+S E YD + WT VA + V + G L+ +
Sbjct: 400 HKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVI 459
Query: 489 -GGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSV 547
GG D ++ V+ Y+P+ N W A++ + L +YVAGG ++
Sbjct: 460 GGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG-----LTKAI 514
Query: 548 ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG-NDGSSSLNSIEKYNPRTN 602
Y P W V R+ + +G +Y +GG + + ++I Y+P T+
Sbjct: 515 YCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATS 570
Score = 89.7 bits (221), Expect = 7e-18
Identities = 61/184 (33%), Positives = 94/184 (51%), Gaps = 8/184 (4%)
Query: 446 GASCLNSAERYDPLTGTWTSVAAMS--TRRRYVRVATLDGNLYAVGGYDSSSHLATVEKY 503
G L E YDP+TG W S+A + T+ Y V L ++ GG +S V Y
Sbjct: 325 GGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYA-VCALRNDILVSGGRINSRD---VWIY 380
Query: 504 EPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPM 563
Q+N+W VAS+ R +AVL G +YV GG DG + L+SVE Y + W VAP+
Sbjct: 381 NSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPL 440
Query: 564 NIRRSTHDLVAMDGWLYAVGGN-DGSSSLNSIEKYNPRTNKW-VAASCMFTRRSSVGVAV 621
S+ + + G L+ +GG D ++ + ++ Y+P TN W + A+ +R V++
Sbjct: 441 KEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSL 500
Query: 622 LELL 625
L+
Sbjct: 501 NNLI 504
Score = 62.8 bits (151), Expect = 1e-09
Identities = 49/172 (28%), Positives = 74/172 (43%), Gaps = 9/172 (5%)
Query: 450 LNSAERYDPLTGTWTSVAAMSTRRR-YVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVN 508
L+ A RY L S R Y V + G VGG++ L E Y+P
Sbjct: 285 LHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFN----LPYTECYDPVTG 340
Query: 509 VWSPVASMLS-RRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRR 567
W +A + +S V L + V+GG + V Y+ + W VA +N R
Sbjct: 341 EWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS---RDVWIYNSQLNIWIRVASLNKGR 397
Query: 568 STHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGV 619
H + + G +Y VGG DG + L+S+E Y+ +N+W + + SS V
Sbjct: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAV 449
Score = 53.5 bits (127), Expect = 6e-07
Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 7/128 (5%)
Query: 344 LFAVGGGSLFAIHGD-CEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSD 402
LF +GGG D ++YD T+ W + A++ + + ++ N +Y GG
Sbjct: 456 LFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLT---- 511
Query: 403 LATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGY-DGASCLNSAERYDPLTG 461
+ YDPV + W + +R+ G++ +G +Y GG + ++ YDP T
Sbjct: 512 -KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATS 570
Query: 462 TWTSVAAM 469
T VAAM
Sbjct: 571 IITGVAAM 578
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 275 bits (703), Expect = 9e-74
Identities = 181/535 (33%), Positives = 254/535 (47%), Gaps = 31/535 (5%)
Query: 82 MSRMRQRGLLCDIVLHVAA-KEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDP 140
+S++R D+ L A ++ AH+ VLA+ SPYF AMF ++ ESR V LH + P
Sbjct: 25 LSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLRESRAERVRLHGVPP 84
Query: 141 QALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGF 200
L L+ F+YT + V N + LL AA LLQ V++AC FL QLD +NCL ++ F
Sbjct: 85 DMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQQQLDLANCLDMQDF 144
Query: 201 ADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVL 260
A+A SCS L AA R++L+H ++ E+ LPL ++L + D L VP EE Y+ L
Sbjct: 145 AEAFSCSGLASAAQRFILRHVGELG-AEQLERLPLARLLRYLRDDGLCVPKEEAAYQLAL 203
Query: 261 SWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLL 320
WV+ D R H P+L++ VRLP + R +LL HV+AE LV P C LL EA F
Sbjct: 204 RWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPPCLRLLREARDFQAA 263
Query: 321 PEQRGVLG-TSRTRPRRCEGAGPVLFAVGGGSLFAIHGDC------EAYDTRTDRWHVVA 373
R G R RPR G +L VGG DC + Y+ +T +W +A
Sbjct: 264 RYDRHDRGPCPRMRPRPSTGLAEILVLVGG-----CDQDCDELVTVDCYNPQTGQWRYLA 318
Query: 374 SMSTR-RARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVA 432
+ A+GN +Y GG DG+ V Y+ N W M R +
Sbjct: 319 EFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSS 378
Query: 433 ALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYD 492
L GLLY +S ERYD T +W ++ M+ G LYA+G
Sbjct: 379 VLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSL- 430
Query: 493 SSSHLATVEKYEPQVNVWSPV-ASMLSRRSSA-GVAVLEGALYVAGGNDGTSCLNSVERY 550
+ ++ Y+P ++WS V L S A A L G +Y + V+ Y
Sbjct: 431 AGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSA-----EVDVY 485
Query: 551 SPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNS-IEKYNPRTNKW 604
+P W+ + MN L + G LY GG D + L+ +E Y+P T W
Sbjct: 486 NPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAW 540
Score = 71.6 bits (174), Expect = 2e-12
Identities = 52/176 (29%), Positives = 76/176 (43%), Gaps = 20/176 (11%)
Query: 350 GSLFAIHGDC-EAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVES 408
G L+ + D E YD TD W + M+ A RLYA+G G + ++
Sbjct: 382 GLLYVVAADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMV-MQC 440
Query: 409 YDPVTNTWQ-------PEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTG 461
YDP T+ W P S + A L+GL+Y D A + Y+P
Sbjct: 441 YDPDTDLWSLVDCGQLPPWSFAPK-----TATLNGLMYFVRD-DSAE----VDVYNPTRN 490
Query: 462 TWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLA-TVEKYEPQVNVWSPVASM 516
W + +M+ +A L G LY GGYD++ L+ VE Y+P+ WS V +
Sbjct: 491 EWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRL 546
Score = 47.0 bits (110), Expect = 5e-05
Identities = 30/105 (28%), Positives = 51/105 (48%), Gaps = 3/105 (2%)
Query: 520 RSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPM-NIRRSTHDLVAMDGW 578
R S G+A E + V G + L +V+ Y+P+ G W +A + + +VA+
Sbjct: 279 RPSTGLA--EILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGND 336
Query: 579 LYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
+Y GG+DGS + + +YN N+W + M R +VL+
Sbjct: 337 IYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLD 381
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 258 bits (659), Expect = 1e-68
Identities = 167/563 (29%), Positives = 272/563 (48%), Gaps = 49/563 (8%)
Query: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141
++ +R+ G CD+ L V E+ AH+ VLA CSPY +F ++ +HV D++P+
Sbjct: 22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPE 81
Query: 142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFA 201
A++ L+ +AYTA++ + V+ + AA L+++ V+ C +LLS++D ++C+ R FA
Sbjct: 82 AVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFA 141
Query: 202 DAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLS 261
S LL Y+ +H + +++ EEF+ LP + LE++ D++ +PS ++Y V++
Sbjct: 142 SCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLP-RLKLEVMLEDNVCLPSNGKLYTKVIN 200
Query: 262 WVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP 321
WV+ + + LM+ V+ S D L L +LL
Sbjct: 201 WVQRSIWENGDSLEELMEEVQTLYYSADHKL----------------------LDGNLLD 238
Query: 322 EQRGVLGTS-------RTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVAS 374
Q V G+ + +P R G + S + + W +VAS
Sbjct: 239 GQAEVFGSDDDHIQFVQKKPPRENGHKQI----SSSSTGCLSSPNATVQSPKHEWKIVAS 294
Query: 375 MSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTW------------QPEVSM 422
T AV + ++ V G + + + P + +P M
Sbjct: 295 EKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPM 354
Query: 423 GTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLD 482
RS LG A ++G L +AGGY+ CL + E Y+P T W+ +A M T R ++A L
Sbjct: 355 QYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLM 414
Query: 483 GNLYAVGGYDS-SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGND-- 539
G LY VGG + S L+ E Y+ ++ W PV + + R +AGV L G LY+ GG+D
Sbjct: 415 GQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPY 474
Query: 540 GTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNP 599
G L + + + P W S AP+NIRR + + G+LY +GG + + LN++E+YNP
Sbjct: 475 GQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNP 534
Query: 600 RTNKWVAASCMFTRRSSVGVAVL 622
N W + M R GVAVL
Sbjct: 535 ENNTWTLIAPMNVARRGAGVAVL 557
Score = 190 bits (482), Expect = 4e-48
Identities = 107/264 (40%), Positives = 145/264 (54%), Gaps = 3/264 (1%)
Query: 344 LFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSD- 402
L A GG + E Y+ TD W +A M T RAR +A + +LY VGG +G SD
Sbjct: 370 LIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDD 429
Query: 403 LATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYD--GASCLNSAERYDPLT 460
L+ E YD + W P + T R GV AL+G LY GG D G L + + +DP+T
Sbjct: 430 LSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVT 489
Query: 461 GTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRR 520
WTS A ++ RR V L G LY +GG +S + L TVE+Y P+ N W+ +A M R
Sbjct: 490 KLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVAR 549
Query: 521 SSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLY 580
AGVAVL G L+V GG DG+ ++ VE Y P W+ + M RS + + +Y
Sbjct: 550 RGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIY 609
Query: 581 AVGGNDGSSSLNSIEKYNPRTNKW 604
AVGG DG+ LN++E YN +N+W
Sbjct: 610 AVGGFDGNEFLNTVEVYNLESNEW 633
Score = 162 bits (410), Expect = 9e-40
Identities = 90/254 (35%), Positives = 134/254 (52%), Gaps = 3/254 (1%)
Query: 372 VASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGV 431
++ M R+ +G A + +L A GGY+ L TVE Y+P T+ W M T R+ +
Sbjct: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQM 410
Query: 432 AALHGLLYSAGGYDGASC-LNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGG 490
A L G LY GG +G S L+ E YD W V + T R V L+G LY VGG
Sbjct: 411 AVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGG 470
Query: 491 YD--SSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVE 548
D L + ++P +W+ A + RR + V L G LY+ GG + +CLN+VE
Sbjct: 471 SDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVE 530
Query: 549 RYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAAS 608
RY+P+ W +APMN+ R + ++G L+ GG DGS +++ +E Y+P N+W
Sbjct: 531 RYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMG 590
Query: 609 CMFTRRSSVGVAVL 622
M + RS+ G+A +
Sbjct: 591 NMTSPRSNAGIATV 604
Score = 123 bits (309), Expect = 5e-28
Identities = 68/188 (36%), Positives = 97/188 (51%), Gaps = 3/188 (1%)
Query: 327 LGTSRTRPRRCEGAGPVLFAVGGGSLFAIHG--DCEAYDTRTDRWHVVASMSTRRARVGV 384
L T+R C G L+ VGG + G +C+ +D T W A ++ RR + V
Sbjct: 449 LRTNRCNAGVCALNGK-LYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAV 507
Query: 385 AAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGY 444
+G LY +GG + + L TVE Y+P NTW M R GVA L+G L+ GG+
Sbjct: 508 CELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGF 567
Query: 445 DGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYE 504
DG+ ++ E YDP W + M++ R +AT+ +YAVGG+D + L TVE Y
Sbjct: 568 DGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYN 627
Query: 505 PQVNVWSP 512
+ N WSP
Sbjct: 628 LESNEWSP 635
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 255 bits (651), Expect = 1e-67
Identities = 174/580 (30%), Positives = 281/580 (48%), Gaps = 24/580 (4%)
Query: 71 SKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKE--IRAHKVVLASCSPYFHAMFTNEMSES 128
S H ++R GLLCD+ L + H+ ++AS S YF AMFT M E
Sbjct: 29 SNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQ 88
Query: 129 RQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188
+ LH ++ L +++ F YTA++ + N+Q L AAS LQ+ V D C FL+S
Sbjct: 89 DLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 148
Query: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248
+ NC+ + A+ ++ ++ K + ++L++F + T EF+ LP +++ ++SS+SL
Sbjct: 149 VSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLK 208
Query: 249 VPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCK 308
+E E+++A W++ + D R + +LMK +R PL++ L+ +V +R C
Sbjct: 209 HCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCV 267
Query: 309 DLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG--GSLFAIHGDCEAYDTRT 366
+LL+EA + ++P + V+ + RT R L +GG + + YD R
Sbjct: 268 NLLLEASNYQMMPYMQPVMQSDRTAIR---SDSTHLVTLGGVLRQQLVVSKELRMYDERA 324
Query: 367 DRWHVVASMSTRRARVGVAAVGNRLYAVGG---YD--GTSDLATVESYDPVTNTWQPEVS 421
W +A M R + G+A +GN LY VGG YD G + + TV +DP N W S
Sbjct: 325 QEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVAS 384
Query: 422 MGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATL 481
+ +R+ ++AL G LY+ GG A L + E Y+P W+ VA MS Y T+
Sbjct: 385 LNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMS-EPHYGHAGTV 443
Query: 482 DGNL-YAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGND- 539
G L Y GG + + ++P + W A M + R + + LYV GGN
Sbjct: 444 YGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHF 503
Query: 540 -GTSCLNSV---ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSS--SLNS 593
GTS + V E YSP W +A M +S + + +Y VGG ++ +
Sbjct: 504 RGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 563
Query: 594 IEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSP 633
++KY+P ++W S G+ L FPP +P
Sbjct: 564 VQKYDPEKDEW--HKVFDLPESLGGIRACTLTVFPPEENP 601
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 254 bits (649), Expect = 2e-67
Identities = 180/598 (30%), Positives = 290/598 (48%), Gaps = 25/598 (4%)
Query: 61 SREGHSVAHNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKE--IRAHKVVLASCSPYFH 118
S+ G + S H ++R GLLCD+ L + H+V++AS S YF
Sbjct: 61 SKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFK 120
Query: 119 AMFTNEMSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVR 178
AMFT M E + LH + L +++ F YTA++ + N+Q L AAS LQ+ V
Sbjct: 121 AMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVL 180
Query: 179 DACCKFLLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQV 238
D C FL+S + NC+ + A+ ++ +++ K + +VL++F + T EF+ LP +++
Sbjct: 181 DFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERL 240
Query: 239 LELVSSDSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAE 298
++SS+SL +E E+++A W++ + + R +LMK +R PL++ L+ +V
Sbjct: 241 AFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTV 299
Query: 299 SLVRHHPDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG--GSLFAIH 356
+R C +LL+EA + ++P + V+ + RT R L +GG +
Sbjct: 300 DFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIR---SDTTHLVTLGGVLRQQLVVS 356
Query: 357 GDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGG---YD--GTSDLATVESYDP 411
+ YD + W +A M R + G+A +GN LY VGG YD G + + TV +DP
Sbjct: 357 KELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDP 416
Query: 412 VTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMST 471
N W S+ +R+ ++AL G LY+ GG + A L + E Y+P T WT VA MS
Sbjct: 417 RYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMS- 475
Query: 472 RRRYVRVATLDGN-LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEG 530
Y T+ G +Y GG + + ++P + W A M + R + +
Sbjct: 476 EPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGE 535
Query: 531 ALYVAGGND--GTSCLNSV---ERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGN 585
LYV GGN GTS + V E YSP W +A M +S + + +Y VGG
Sbjct: 536 RLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY 595
Query: 586 DGSS--SLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLELLNFPPPSSPTLSVSSTS 641
++ + ++KY+P ++W +F S+G L PP T S S S
Sbjct: 596 SWNNRCMVEIVQKYDPDKDEW---HKVFDLPESLGGIRACTLTVFPPEETTPSPSRES 650
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,094,820
Number of Sequences: 37866
Number of extensions: 1391487
Number of successful extensions: 33828
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 661
Number of HSP's successfully gapped in prelim test: 546
Number of HSP's that attempted gapping in prelim test: 18286
Number of HSP's gapped (non-prelim): 9760
length of query: 642
length of database: 18,247,518
effective HSP length: 109
effective length of query: 533
effective length of database: 14,120,124
effective search space: 7526026092
effective search space used: 7526026092
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.