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Search of human proteins with 34486092
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|34486092 adenylate cyclase 5 [Homo sapiens]
(1261 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|34486092 adenylate cyclase 5 [Homo sapiens] 2521 0.0
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 1513 0.0
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 1423 0.0
gi|4557257 adenylate cyclase 8 [Homo sapiens] 772 0.0
gi|31083193 adenylate cyclase 1 [Homo sapiens] 753 0.0
gi|115387102 adenylate cyclase 2 [Homo sapiens] 707 0.0
gi|148536830 adenylate cyclase 3 [Homo sapiens] 663 0.0
gi|4557255 adenylate cyclase 7 [Homo sapiens] 644 0.0
gi|24497587 adenylate cyclase 4 [Homo sapiens] 634 0.0
gi|50959205 adenylate cyclase 9 [Homo sapiens] 215 2e-55
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 123 1e-27
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 116 1e-25
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 116 2e-25
gi|134152694 guanylate cyclase 2F [Homo sapiens] 115 3e-25
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 110 6e-24
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 106 1e-22
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 106 1e-22
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 106 1e-22
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 106 1e-22
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 106 1e-22
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 105 2e-22
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 103 1e-21
gi|222080083 guanylate cyclase 2C [Homo sapiens] 100 1e-20
gi|153070260 myristoylated alanine-rich protein kinase C substra... 52 4e-06
gi|223555958 transmembrane protein 64 isoform 1 [Homo sapiens] 50 2e-05
gi|57864582 hornerin [Homo sapiens] 50 2e-05
gi|226371762 transmembrane protein 64 isoform 2 [Homo sapiens] 48 5e-05
gi|22748877 basic helix-loop-helix domain containing, class B, 5... 47 9e-05
gi|119395750 keratin 1 [Homo sapiens] 45 6e-04
gi|25777671 protein phosphatase 1, regulatory subunit 10 [Homo s... 45 6e-04
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 2521 bits (6535), Expect = 0.0
Identities = 1261/1261 (100%), Positives = 1261/1261 (100%)
Query: 1 MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA 60
MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA
Sbjct: 1 MSGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGA 60
Query: 61 VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR 120
VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR
Sbjct: 61 VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR 120
Query: 121 GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG 180
GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG
Sbjct: 121 GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG 180
Query: 181 GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS 240
GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS
Sbjct: 181 GEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQS 240
Query: 241 SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL 300
SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL
Sbjct: 241 SLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAFHQDHMGL 300
Query: 301 ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL 360
ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL
Sbjct: 301 ACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL 360
Query: 361 HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH 420
HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH
Sbjct: 361 HLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLH 420
Query: 421 SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS 480
SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS
Sbjct: 421 SQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTS 480
Query: 481 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM 540
LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM
Sbjct: 481 LASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEM 540
Query: 541 GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 600
GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK
Sbjct: 541 GMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 600
Query: 601 AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN 660
AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN
Sbjct: 601 AGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKMN 660
Query: 661 RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL 720
RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL
Sbjct: 661 RQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEFL 720
Query: 721 GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI 780
GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI
Sbjct: 721 GRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQI 780
Query: 781 TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF 840
TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF
Sbjct: 781 TIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVF 840
Query: 841 TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP 900
TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP
Sbjct: 841 TITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSP 900
Query: 901 WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL 960
WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL
Sbjct: 901 WPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADL 960
Query: 961 LVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL 1020
LVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL
Sbjct: 961 LVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKL 1020
Query: 1021 QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF 1080
QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF
Sbjct: 1021 QATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANF 1080
Query: 1081 SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY 1140
SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY
Sbjct: 1081 SEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTY 1140
Query: 1141 DKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG 1200
DKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG
Sbjct: 1141 DKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWG 1200
Query: 1201 NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL 1260
NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL
Sbjct: 1201 NTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPL 1260
Query: 1261 S 1261
S
Sbjct: 1261 S 1261
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 1513 bits (3916), Expect = 0.0
Identities = 791/1165 (67%), Positives = 908/1165 (77%), Gaps = 20/1165 (1%)
Query: 100 KSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVG 159
K+AW ER G R +RRG +GG + + + G P +
Sbjct: 16 KTAWGERNGQ-----KRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAF 70
Query: 160 LEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLG-ACCLALLQIFRS 218
+ RRG EL AV G + ++A + P AV G +C L+Q+F+S
Sbjct: 71 I--RRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQS 128
Query: 219 KKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAV 278
K+F S KLERLYQRYFF++NQSSLT+LMAVLVL+ V+LAFHAA Q Y+A+LA A
Sbjct: 129 KQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAA 188
Query: 279 GVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYT 338
+ + + V+CNR +F QD M + Y ++ ++ AVQV G L PRS S G+W VFF+Y
Sbjct: 189 ALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYI 248
Query: 339 IYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHY 398
YTLLP+RMRAAVLSG+ LS LHL +A + N D FL KQL +NVL+F CTN++G+CTHY
Sbjct: 249 AYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHY 308
Query: 399 PAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFH 458
PAEVSQRQAFQETR IQARLH Q EN+QQERLLLSVLP+HVAMEMK DIN K+EDMMFH
Sbjct: 309 PAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFH 368
Query: 459 KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD 518
KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD
Sbjct: 369 KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD 428
Query: 519 CYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 578
CYYCVSGLPEARADHAHCCVEMG+DMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR
Sbjct: 429 CYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 488
Query: 579 KWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIE 638
KWQFDVWSNDVTLANHMEAGG+AGRIHIT+ATL YLNGDYEVEPG GGERNAYLKE IE
Sbjct: 489 KWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIE 548
Query: 639 TFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGF 698
TFLIL +QKRKEEKAM+AK+ R R NS+ P W +R F + SK ++MG
Sbjct: 549 TFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAF----SRTKDSKAFRQMGI 604
Query: 699 EDPKDKN--AQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQ 756
+D N Q++ NPEDEVDEFL RAIDARSID+LR +HVR+FLLTF+ DLEKKYS++
Sbjct: 605 DDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRK 664
Query: 757 VDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLF 816
VD RFGAYVACA LVF FICF+Q+ I PHS ML Y + LLL + V + +YSC LF
Sbjct: 665 VDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLF 724
Query: 817 PSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQV 876
P LQ LSR IVRS+ +ST VG+F++ LVF +A NMFTCN + C A+ N++ + +
Sbjct: 725 PKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADI 784
Query: 877 NACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLM 936
ACH+ + +NYSLG + C P C+FPEYF ++LLSLLA SVFL IS IGKL ++
Sbjct: 785 TACHLQQ--LNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMI 842
Query: 937 LAIELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTS--QCPEHATKVALKVVTPII 993
+ LIY VL++ P T+FDN DLL+ + + N CP A +VALK +TP+I
Sbjct: 843 FVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPA-AGRVALKYMTPVI 901
Query: 994 ISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL 1053
+ VF LALYLHAQQVESTARLDFLWKLQAT EKEEMEELQAYNRRLLHNILPKDVAAHFL
Sbjct: 902 LLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFL 961
Query: 1054 ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 1113
ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE
Sbjct: 962 ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 1021
Query: 1114 DRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNF 1173
+RFRQLEKIKTIGSTYMAASGLN STYD+VG++HI ALAD+AM+LM+QMK+INEHSFNNF
Sbjct: 1022 ERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNF 1081
Query: 1174 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTY 1233
QMKIGLN+GPVVAGVIGARKPQYDIWGNTVNV+SRMDSTGVPDRIQVTTD+YQVLAA Y
Sbjct: 1082 QMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGY 1141
Query: 1234 QLECRGVVKVKGKGEMMTYFLNGGP 1258
QLECRGVVKVKGKGEM TYFLNGGP
Sbjct: 1142 QLECRGVVKVKGKGEMTTYFLNGGP 1166
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 1423 bits (3684), Expect = 0.0
Identities = 764/1165 (65%), Positives = 871/1165 (74%), Gaps = 73/1165 (6%)
Query: 100 KSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVG 159
K+AW ER G R +RRG +GG + + + G P +
Sbjct: 16 KTAWGERNGQ-----KRSRRRGTRAGGFCTPRYMSCLRDAEPPSPTPAGPPRCPWQDDAF 70
Query: 160 LEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLG-ACCLALLQIFRS 218
+ RRG EL AV G + ++A + P AV G +C L+Q+F+S
Sbjct: 71 I--RRGGPGKGKELGLRAVALGFEDTEVTTTAGGTAEVAPDAVPRSGRSCWRRLVQVFQS 128
Query: 219 KKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAV 278
K+F S KLERLYQRYFF++NQSSLT+LMAVLVL+ V+LAFHAA Q Y+A+LA A
Sbjct: 129 KQFRSAKLERLYQRYFFQMNQSSLTLLMAVLVLLTAVLLAFHAAPARPQPAYVALLACAA 188
Query: 279 GVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYT 338
+ + + V+CNR +F QD M + Y ++ ++ AVQV G L PRS S G+W VFF+Y
Sbjct: 189 ALFVGLMVVCNRHSFRQDSMWVVSYVVLGILAAVQVGGALAADPRSPSAGLWCPVFFVYI 248
Query: 339 IYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHY 398
YTLLP+RMRAAVLSG+ LS LHL +A + N D FL KQL +NVL+F CTN++G+CTHY
Sbjct: 249 AYTLLPIRMRAAVLSGLGLSTLHLILAWQLNRGDAFLWKQLGANVLLFLCTNVIGICTHY 308
Query: 399 PAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFH 458
PAEVSQRQAFQETR IQARLH Q EN+QQERLLLSVLP+HVAMEMK DIN K+EDMMFH
Sbjct: 309 PAEVSQRQAFQETRGYIQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFH 368
Query: 459 KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD 518
KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD
Sbjct: 369 KIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGD 428
Query: 519 CYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 578
CYYCVSGLPEARADHAHCCVEMG+DMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR
Sbjct: 429 CYYCVSGLPEARADHAHCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLR 488
Query: 579 KWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIE 638
KWQFDVWSNDVTLANHMEAGG+AGRIHIT+ATL YLNGDYEVEPG GGERNAYLKE IE
Sbjct: 489 KWQFDVWSNDVTLANHMEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIE 548
Query: 639 TFLILRCTQKRKEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGF 698
TFLIL +QKRKEEKAM+AK+ R R NS+ P W +R F + SK ++MG
Sbjct: 549 TFLILGASQKRKEEKAMLAKLQRTRANSMEGLMPRWVPDRAF----SRTKDSKAFRQMGI 604
Query: 699 EDPKDKN--AQESANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQ 756
+D N Q++ NPEDEVDEFL RAIDARSID+LR +HVR+FLLTF+ DLEKKYS++
Sbjct: 605 DDSSKDNRGTQDALNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRK 664
Query: 757 VDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLF 816
VD RFGAYVACA LVF FICF+Q+ I PHS ML Y + LLL + V + +YSC LF
Sbjct: 665 VDPRFGAYVACALLVFCFICFIQLLIFPHSTLMLGIYASIFLLLLITVLICAVYSCGSLF 724
Query: 817 PSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQV 876
P LQ LSR IVRS+ +ST VG+F++ LVF +A NM+ + LL LA
Sbjct: 725 PKALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNM-LLSLLAS--------- 774
Query: 877 NACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLM 936
SV L + S IGKL ++
Sbjct: 775 ------------------------------------SVFLHI---------SSIGKLAMI 789
Query: 937 LAIELIY-VLIVEVPGVTLFDNADLLVTANAIDFFNNGTS--QCPEHATKVALKVVTPII 993
+ LIY VL++ P T+FDN DLL+ + + N CP A +VALK +TP+I
Sbjct: 790 FVLGLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPA-AGRVALKYMTPVI 848
Query: 994 ISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFL 1053
+ VF LALYLHAQQVESTARLDFLWKLQAT EKEEMEELQAYNRRLLHNILPKDVAAHFL
Sbjct: 849 LLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFL 908
Query: 1054 ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 1113
ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE
Sbjct: 909 ARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISE 968
Query: 1114 DRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNF 1173
+RFRQLEKIKTIGSTYMAASGLN STYD+VG++HI ALAD+AM+LM+QMK+INEHSFNNF
Sbjct: 969 ERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMRLMEQMKHINEHSFNNF 1028
Query: 1174 QMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTY 1233
QMKIGLN+GPVVAGVIGARKPQYDIWGNTVNV+SRMDSTGVPDRIQVTTD+YQVLAA Y
Sbjct: 1029 QMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGY 1088
Query: 1234 QLECRGVVKVKGKGEMMTYFLNGGP 1258
QLECRGVVKVKGKGEM TYFLNGGP
Sbjct: 1089 QLECRGVVKVKGKGEMTTYFLNGGP 1113
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 772 bits (1994), Expect = 0.0
Identities = 463/1162 (39%), Positives = 668/1162 (57%), Gaps = 74/1162 (6%)
Query: 121 GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAA--DELEAGAV 178
G+ SGGS +A GGG + A +G + + S+ G G + +G+
Sbjct: 59 GSGSGGSGKASDPAGGGPNHHAPQLSGDSALPLYSLGPGERAHSTCGTKVFPERSGSGSA 118
Query: 179 EGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLN 238
G G GD G + + L+ G ++ F S LERLYQRYF
Sbjct: 119 SGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFLGQR 178
Query: 239 QSSLTMLMAVLVLVCLVMLAFH-----AARPPLQLPYLAVLAAAVGVILIMAVLCNRAAF 293
+ S ++ + VL L +L H A PL+ L VI + V+
Sbjct: 179 RKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKDTTS 238
Query: 294 HQ--DHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAV 351
H + G+ + + + +G L +GI + +F ++ Y++LP+ + A+
Sbjct: 239 HTYLQYSGVVTWVAMTTQILAAGLGYGL-----LGDGIGYVLFTLFATYSMLPLPLTWAI 293
Query: 352 LSGVLLSALHLAIALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQET 411
L+G+ S L + + + + Q+V+ ++F C N G+ Y ++ +QRQAF ET
Sbjct: 294 LAGLGTSLLQVILQVVIPRLAVISINQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLET 353
Query: 412 RECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMM---FHKIYIQKHDNV 468
R C++ARL + ENQ+QERL+LSVLPR V +EM D+ +++ + FH+IYI +++NV
Sbjct: 354 RRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENV 413
Query: 469 SILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPE 528
SILFAD++GFT+L++ +AQELV LNELFARFD+LA E+HCLRIKILGDCYYCVSGLPE
Sbjct: 414 SILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPE 473
Query: 529 ARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSND 588
R DHAHCCVEMG+ MI+ I VR T +V+MR+GIHSG V CGVLGLRKWQFDVWS D
Sbjct: 474 PRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWD 533
Query: 589 VTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQK 648
V +AN +E+GG GRIHI+KATL+ LNGDY VE G G ERN +L++H+IET+LI +
Sbjct: 534 VDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEDS 593
Query: 649 RKEEKAMIAK----MNRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDK 704
I K + +R + W E PF N +G + R +
Sbjct: 594 LLSLPEDIVKESVSSSDRRNSGATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNH 653
Query: 705 NAQE---SANPEDEVDEFLGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRF 761
AQ + PE E+++ + ID RS D+LR EH++ F L F++ LE KYS+ D+ F
Sbjct: 654 LAQALHVQSGPE-EINKRIEHTIDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVF 712
Query: 762 GAYVACASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQ 821
+ + CA +V LFI +Q + + ++ + ++L + + K P L+
Sbjct: 713 KSNLVCAFIVLLFITAIQSLLPSSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLILR 772
Query: 822 TLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHV 881
I + + ++ +I + FL A +N+ C+ + N SA +
Sbjct: 773 KTCCWINETYLARNVIIFASILINFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDI--- 829
Query: 882 AESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIEL 941
C++PEYF ++ +L+++ C+VFL+++ + KL ++L +
Sbjct: 830 ----------------------CSYPEYFVFTGVLAMVTCAVFLRLNSVLKLAVLLIMIA 867
Query: 942 IYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLAL 1001
IY L+ E LF D L + DF + K V+ +++++F+LA+
Sbjct: 868 IYALLTETVYAGLFLRYDNL-NHSGEDF--------------LGTKEVSLLLMAMFLLAV 912
Query: 1002 YLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDE 1061
+ H QQ+E TARLDFLW++QA EE EM+EL+ +N +L NILP VA HFL ++R N+E
Sbjct: 913 FYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEE 972
Query: 1062 LYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEK 1121
LY QS + V VMFASI F++FY + E NN+GVECLRLLNEIIADFDE++ EDRF+ +EK
Sbjct: 973 LYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEK 1032
Query: 1122 IKTIGSTYMAASGLN---DSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIG 1178
IKTIGSTYMA SGL+ DK G H+ ALADF++ L + ++ IN+HSFNNF+++IG
Sbjct: 1033 IKTIGSTYMAVSGLSPEKQQCEDKWG--HLCALADFSLALTESIQEINKHSFNNFELRIG 1090
Query: 1179 LNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECR 1238
++ G VVAGVIGA+KPQYDIWG TVN+ASRMDSTGV RIQV + Y +L + + R
Sbjct: 1091 ISHGSVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYR 1150
Query: 1239 GVVKVKG----KGEMMTYFLNG 1256
G + VKG +G++ TYFL G
Sbjct: 1151 GEIYVKGISEQEGKIKTYFLLG 1172
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 753 bits (1944), Expect = 0.0
Identities = 463/1121 (41%), Positives = 640/1121 (57%), Gaps = 105/1121 (9%)
Query: 175 AGAVEGGEGSGDG-GSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRY 233
AGA GG G G G G + AG L AC ++F +LE L++ Y
Sbjct: 2 AGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRAC---------DEEFACPELEALFRGY 52
Query: 234 FFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAF 293
RL Q++ +AVL L+ + P P LA + V +L +A+L
Sbjct: 53 TLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVR 112
Query: 294 HQDHMGLACYALIAVVLAVQVVGLLLP---------------QPRSASEGIWWTVFFIYT 338
L +A++ ++ L P P +A +G+W + +
Sbjct: 113 SLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFV 172
Query: 339 IYTLLPVRMRAAVLSGVLLSALHLAI-ALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTH 397
Y LLPVR A+ G++++A HL + A A+ L + L +N L+F N+ GV
Sbjct: 173 SYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVR 232
Query: 398 YPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMF 457
E SQR+AF + R CI+ RL + EN++QERLL+S+LPR+VAMEMK D K + +F
Sbjct: 233 ILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF-LKPPERIF 291
Query: 458 HKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILG 517
HKIYIQ+HDNVSILFADI GFT LASQCTAQELV LNELF +FD+LA ENHC RIKILG
Sbjct: 292 HKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILG 351
Query: 518 DCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGL 577
DCYYCVSGL + + DHAHCCVEMG+DMI+ I+ V E T V++NMRVG+H+GRV CGVLGL
Sbjct: 352 DCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGL 411
Query: 578 RKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSI 637
RKWQ+DVWSNDVTLAN MEA G G++HITK TL LNGDYEVEPG G ERN++LK H+I
Sbjct: 412 RKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNI 471
Query: 638 ETFLILRCTQKR----------KEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGN 687
ETF I+ +++ K K M K + H + AE PF N +
Sbjct: 472 ETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVM--- 528
Query: 688 QVSKEMKRMGFEDPKDKNAQESA--------NPEDEVDEFLGRAIDARSIDRLRSEHVRK 739
+ KR +K S+ P V+ ++ R ++AR + L +
Sbjct: 529 TCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTE-LEMADLNF 587
Query: 740 FLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTC-SL 798
F L ++ + E+KY + D+ F + V ++ V + I P S+ +L + C
Sbjct: 588 FTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICF 647
Query: 799 LLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNS 858
L+ V+++ + + V+ FP L R T++ +F + L++ A
Sbjct: 648 LVACVLYLHI--TRVQCFPGCLTIQIR---------TVLCIFIVVLIYSVA--------Q 688
Query: 859 RDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSL 918
++GCL +S+ N+ S V S G ++ P C + L+
Sbjct: 689 GCVVGCLPWAW---SSKPNS-----SLVVLSSGGQR--TALPTLPCESTHHALLCCLVGT 738
Query: 919 LACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCP 978
L ++F ++S + K++L+ + Y+L++E+ G T + +G S P
Sbjct: 739 LPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAV-----------SGRSYEP 787
Query: 979 EHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRR 1038
+ I +F AL LHA+QV+ RLD+LW QA EE+E+ME+++ NRR
Sbjct: 788 ------------IVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRR 835
Query: 1039 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR 1098
+L N+LP VA HFL RN +LYYQS V VMFASI NF++FY+EL+ NN GVECLR
Sbjct: 836 ILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLR 895
Query: 1099 LLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGK---THIKALADFA 1155
LLNEIIADFDE++ +D ++ +EKIKTIGSTYMAA GL ++ K K +H+ LADFA
Sbjct: 896 LLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFA 955
Query: 1156 MKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVP 1215
+++ D + IN S+N+F +++G+N+GPVVAGVIGAR+PQYDIWGNTVNVASRMDSTGV
Sbjct: 956 IEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQ 1015
Query: 1216 DRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1256
RIQVT +++++L Y CRG V VKGKGEM+TYFL G
Sbjct: 1016 GRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEG 1056
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 707 bits (1825), Expect = 0.0
Identities = 421/1076 (39%), Positives = 631/1076 (58%), Gaps = 80/1076 (7%)
Query: 229 LYQRYFFRLNQSSLTMLMAVLVL-VCLVMLA-FHAARPPLQ--LPYLAVLAAAVGVILIM 284
LY+ Y+ Q L + + ++V+ CL +LA F A ++ + +L + A+ + +
Sbjct: 33 LYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAI 92
Query: 285 AVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLP 344
+L + + + L + ++A+ + + S + + + +F I+ +YT+LP
Sbjct: 93 FILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLP 152
Query: 345 VRMRAAVLSGVLLSALH---LAIALR-TNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPA 400
MR A+++ VL S+ H L++ L T + L+ Q+++NV+IF C N+ G +
Sbjct: 153 FNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLM 212
Query: 401 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAK--------- 451
E++ +Q +Q+T CI++R+ + E +QQERLLLS+LP H+AMEMKA+I +
Sbjct: 213 ELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQM 272
Query: 452 QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 511
+ FH +Y+++H NVSIL+ADI GFT LAS C+ ELV LNELF +FD++A EN C+
Sbjct: 273 ENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECM 332
Query: 512 RIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVH 571
RIKILGDCYYCVSGLP + +HA CV+MG+DM EAI VR+ TGV++NMRVG+HSG V
Sbjct: 333 RIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVL 392
Query: 572 CGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAY 631
CGV+GL+KWQ+DVWS+DVTLANHMEAGG GR+HI+ TL +LNG Y+VE G G R+ Y
Sbjct: 393 CGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPY 452
Query: 632 LKEHSIETFLILRCTQKRKEEKAMI--------AKMNRQRTNSIGHNPPHWGAERPFYNH 683
LK+H ++T+ ++ +R+ + + AKM + + + WGA +PF +
Sbjct: 453 LKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKM--RASVRMTRYLESWGAAKPFAHL 510
Query: 684 LGGNQVSKE----------MKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDR-- 731
+ ++ E M + F++ + + E+E++E + +AID + +
Sbjct: 511 HHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQW 570
Query: 732 LRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPH-SIFML 790
L+SE +++ L F LEK+Y F YV CA L+F I VQI ++P S+ +
Sbjct: 571 LKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI 630
Query: 791 SFYLTCSLL--LTLVVFVSVIYSCVKLFPSPLQTLSRK---IVRSKMNSTLVGVFTITLV 845
SF LL + V F + C K L L + I + + T ++
Sbjct: 631 SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAII 690
Query: 846 FLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCN 905
+ A NMF L+ N + + SA N + + N
Sbjct: 691 LMMAVFNMF---------FLSDSEETIPPTANTTNTSFSASNNQVAILRA------QNLF 735
Query: 906 FPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTAN 965
F YF YS +L L++CSVFL+++ K+++M+ V +V + L +A +L +
Sbjct: 736 FLPYFIYSCILGLISCSVFLRVNYELKMLIMM------VALVGYNTILLHTHAHVLGDYS 789
Query: 966 AIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEE 1025
+ F G + LK + + +S+F + L + +Q E RLDFLWK + +E
Sbjct: 790 QVLFERPGIWK--------DLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKE 841
Query: 1026 KEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYV 1085
+EE+E ++ NR LL N+LP VA HFLAR +N+ELY+QS +CV VMFASI +F EFY
Sbjct: 842 REEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYT 901
Query: 1086 ELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLN------DST 1139
E + N EG+ECLRLLNEIIADFD+++S+ +F +EKIKTIGSTYMAA+GL+ S
Sbjct: 902 ESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQ 961
Query: 1140 YDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIW 1199
+ HI + +FA L+ ++ IN+HSFN+F++++G+N GPV+AGVIGA+KPQYDIW
Sbjct: 962 EPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIW 1021
Query: 1200 GNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLN 1255
GNTVNVASRMDSTGV D+IQVT + VL Y CRG++ VKGKG++ TYF+N
Sbjct: 1022 GNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVN 1077
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 663 bits (1710), Expect = 0.0
Identities = 414/1156 (35%), Positives = 635/1156 (54%), Gaps = 92/1156 (7%)
Query: 166 KGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDK 225
+ + E E A E S S D G G + CL L + R P +
Sbjct: 3 RNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVP-ES 61
Query: 226 LERLYQRYFFRLNQSSLTMLMAVLVLV-CLVMLAFHAARPPLQLPYLAVLAAAVGVILIM 284
LE LYQ YF R +L +L+ L C V++ +L LAV + + +I+
Sbjct: 62 LENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIIL 121
Query: 285 AVLCNRAAFHQDHMGLACYALIAVVLAVQV---VGLLLPQPRSASEGIWWTVFFIYTIYT 341
VLC + ++ +++ Q+ +GL + +AS+ + W VFF+++ +
Sbjct: 122 FVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFI 181
Query: 342 LLPVRMRAAVLSGVLLSALHLAIALRTNAQDQF-------LLKQLVSNVLIFSCTNIVGV 394
LP+ + V+ V+ +H + T AQ Q LL+++++NV ++ C VG+
Sbjct: 182 TLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGI 241
Query: 395 CTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADIN---AK 451
++Y A+ R+AF E R+ ++ +++ + ++QQQE L+LS+LP+HVA EM D+ ++
Sbjct: 242 MSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQ 301
Query: 452 QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCL 511
++ F+ +Y+ +H+NVSILFADI GFT L+S C+AQELV LNELFARFDKLAA+ H L
Sbjct: 302 KDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQL 361
Query: 512 RIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVH 571
RIKILGDCYYC+ GLP+ R DHA C + MG+ M+EAIS VRE T V+MRVG+H+G V
Sbjct: 362 RIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVL 421
Query: 572 CGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAY 631
GVLG ++WQ+DVWS DVT+AN MEAGG GR+HI+++T++ L G+++VEPG GG R Y
Sbjct: 422 GGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDY 481
Query: 632 LKEHSIETFLILRCTQKRKEEKAM-----IAKMNRQRTNSIGHNPPHWGAERPFYN-HLG 685
L+E IET+LI+ + K+ A N +S +P + P + H
Sbjct: 482 LEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSS 541
Query: 686 GNQVSK-EMKRMGFEDPKDKNAQESANPEDEVDEFLGRAIDARSIDRLRSEHV------- 737
G+ K E + ++P N + +D D + + D +++L +E +
Sbjct: 542 GSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQ 601
Query: 738 -----RKFLLT--FREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFML 790
FLL+ F +P++E +YS + + + GA +C+ +V L V+I I P +
Sbjct: 602 VVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNY 661
Query: 791 SFYLTCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAF 850
++ +LL ++ S+ + FP L S I R++ + I ++ +A
Sbjct: 662 VTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANV 721
Query: 851 VNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYF 910
V+M +C L N +A + +G C P+Y+
Sbjct: 722 VDMLSC-----LQYYTGPSNATAGM----------------ETEGSC------LENPKYY 754
Query: 911 TYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNAD---------LL 961
Y +LSL+A + +Q+S + KL LML + I +FD D +
Sbjct: 755 NYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPM 814
Query: 962 VTANAIDFFN---NGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLW 1018
V + FN NGT + P +K ++ V ++ + +L+ Y ++ VE AR FLW
Sbjct: 815 VALEQMQGFNPGLNGTDRLPLVPSKYSMTV----MVFLMMLSFYYFSRHVEKLARTLFLW 870
Query: 1019 KLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIA 1078
K++ ++KE + E++ +N L+ N+LP+ VA HFL ++R++ELY Q+ + + VMFAS+
Sbjct: 871 KIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLP 930
Query: 1079 NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLND- 1137
NF++FY E NN G+ECLR LNEII+DFD ++ +FR + KIKTIGSTYMAASG+
Sbjct: 931 NFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPD 990
Query: 1138 ------STYDKVGKT------HIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVV 1185
++ +K K+ H+ LADFA+ + D + IN SFNNF ++IG+N G V+
Sbjct: 991 VNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVL 1050
Query: 1186 AGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKG 1245
AGVIGARKP YDIWGNTVNVASRM+STGV IQV + +L ++ RG + VKG
Sbjct: 1051 AGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKG 1110
Query: 1246 KGEMMTYFLNGGPPLS 1261
KGE++T+FL G L+
Sbjct: 1111 KGELLTFFLKGRDKLA 1126
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 644 bits (1662), Expect = 0.0
Identities = 413/1088 (37%), Positives = 600/1088 (55%), Gaps = 99/1088 (9%)
Query: 227 ERLYQRYFFRLNQSSLTM---LMAVLVLVCLVMLAFHAARPPLQLPYLA----VLA--AA 277
+ LY++Y L + L+A V L+++AF P L VLA AA
Sbjct: 19 DALYEKYQLTSQHGPLLLTLLLVAATACVALIIIAFSQGDPSRHQAILGMAFLVLAVFAA 78
Query: 278 VGVILIMAVLCNRAAFHQDHMGLACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIY 337
+ V++ + L R + AC + VL + A E + + +F ++
Sbjct: 79 LSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDA----WTKAACAWEQVPFFLFIVF 134
Query: 338 TIYTLLPVRMRAAVLSGVLLSALHLAI------ALRTNAQDQFLLKQLVSNVLIFSCTNI 391
+YTLLP MR AV G + +A HL + T + L QL++N +IF C N+
Sbjct: 135 VVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGL--QLLANAVIFLCGNL 192
Query: 392 VGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAK 451
G + + + R F T +CIQ R + E +QQE LLLSVLP H++M MK I +
Sbjct: 193 TGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMGMKLAIIER 252
Query: 452 QE---------DMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFD 502
+ D FH +Y+++H NVSIL+ADI GFT LAS C+ +ELV+ LNELF +FD
Sbjct: 253 LKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFD 312
Query: 503 KLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMR 562
++A N C+RIKILGDCYYCVSGLP + HA CV+MG+DM +AI VRE TGV++NMR
Sbjct: 313 QIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREATGVDINMR 372
Query: 563 VGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEP 622
VGIHSG V CGV+GLRKWQ+DVWS+DV+LAN MEA G GR+HIT+ATL +L+ YEVE
Sbjct: 373 VGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVED 432
Query: 623 GCGGERNAYLKEHSIETFLIL--RCTQ---------KRKEEKAMIAKMNRQRTNSIGHNP 671
G G +R+ YLKE +I T+L++ R Q + K + A+ + + + T +
Sbjct: 433 GHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRASVRMTRYL---- 488
Query: 672 PHWGAERPFYN------------HLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEF 719
WGA RPF + H+ + K + + P + + + +D D+
Sbjct: 489 ESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSMSPKGRSEDDSYDDE 548
Query: 720 LGRAIDARSIDR---LRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFIC 776
+ AI+ S R +S+ F F E E++Y R ACASL+F+ I
Sbjct: 549 MLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDFACASLIFVCIL 608
Query: 777 FVQITIVPHSIFM-LSFYL-TCSLLLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNS 834
V + ++P + + +SF L C L L L + + +S L T+S ++ +
Sbjct: 609 LVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARGTLCTISERVETQPLLR 668
Query: 835 TLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQ 894
+ V TI + A +N+ + V E V G+E
Sbjct: 669 LTLAVLTIGSLLTVAIINL---------------------PLMPFQVPELPV----GNET 703
Query: 895 GFCGSPWPN---CNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPG 951
G + C Y+T S +L +ACSVFL++S K+VL+ + Y+++ +
Sbjct: 704 GLLAASSKTRALCEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLSP 763
Query: 952 VTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVEST 1011
+D + N TS P + K LK +T + +F + L ++Q++
Sbjct: 764 CWQWDCCG--QGLGNLTKPNGTTSGTPSCSWK-DLKTMTNFYLVLFYITLLTLSRQIDYY 820
Query: 1012 ARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVA 1071
RLD LWK + +E EE E ++ NR LL N+LP VAAHF+ ++ N++ Y+QS +CV
Sbjct: 821 CRLDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFIG-DKLNEDWYHQSYDCVC 879
Query: 1072 VMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMA 1131
VMFAS+ +F FY E + N EG+ECLRLLNEIIADFDE++ + +F +EKIKTIGSTYMA
Sbjct: 880 VMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMA 939
Query: 1132 ASGLNDSTYDKVGK-----THIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVA 1186
A+GL+ ++ + + HI + +F++ LM ++ IN HSFN+F++++G+N GPV+A
Sbjct: 940 AAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIA 999
Query: 1187 GVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGK 1246
GVIGARKPQYDIWGNTVNVASRM+STG +IQVT + +L Y ECRG++ VKGK
Sbjct: 1000 GVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGK 1059
Query: 1247 GEMMTYFL 1254
GE+ TYF+
Sbjct: 1060 GELRTYFV 1067
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 634 bits (1635), Expect = 0.0
Identities = 423/1109 (38%), Positives = 609/1109 (54%), Gaps = 98/1109 (8%)
Query: 212 LLQIFRSKKFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVML---AFHAARPPLQL 268
+ ++F + PS+ L Y+ Y+ Q L +L+ +VL L L A+ + R
Sbjct: 1 MARLFSPRPPPSEDL--FYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSD 58
Query: 269 P-YLAVLAAAVGVILIMAVLCNRAA----FHQDHMGLACYALIAVVLAVQVVGLLLPQPR 323
P +L + A+G ++ L +R + + GL AL+A+ A G ++
Sbjct: 59 PSFLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVV---- 114
Query: 324 SASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSALHLAI-ALRTNAQDQF---LLKQL 379
SA + + + +F I+T Y +LP+ MR A ++G+ S HL + L Q LL QL
Sbjct: 115 SAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQL 174
Query: 380 VSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRH 439
+N ++F C N+ GV E + R F+E + +R E + QE LLLS+LP +
Sbjct: 175 AANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAY 234
Query: 440 VAMEMKADINAK---------QEDMMFHKIYIQKHDNVSILFADIEGFTSLASQCTAQEL 490
+A EMKA+I A+ + FH +Y+++H VS+L+ADI GFT LAS+C+ +EL
Sbjct: 235 LAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKEL 294
Query: 491 VMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVEMGMDMIEAISL 550
V+ LNELF +FD++A E+ C+RIKILGDCYYCVSGLP + DHA CV MG+DM AI
Sbjct: 295 VLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRK 354
Query: 551 VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKAT 610
+R TGV++NMRVG+HSG V CGV+GL+KWQ+DVWS+DVTLANHMEAGG GR+HIT AT
Sbjct: 355 LRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGAT 414
Query: 611 LNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEK-------AMIAKMNRQR 663
L L G Y VE R+ YL+E T+L++ + ++EK + + + +
Sbjct: 415 LALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRP 474
Query: 664 TNSIGHNPPHWGAERPFYNHL--GGNQVS-------KEMKRMGFEDPKDKNAQESANPED 714
+ + WGA +PF HL G + VS K + + D++ + +D
Sbjct: 475 SLLMTRYLESWGAAKPFA-HLSHGDSPVSTSTPLPEKTLASFSTQWSLDRS-RTPRGLDD 532
Query: 715 EVDEFLGRAIDARSIDRLRSEHVRK-------FLLTFREPDLEKKYSKQVDDRFGAYVAC 767
E+D G A + I++L S+ K L FRE ++EK+Y F Y AC
Sbjct: 533 ELDT--GDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEAC 590
Query: 768 ASLVFLFICFVQITIVPHSIFMLSFYLTCSLLLTLVVFVSV---IYSCVKLFPSPLQ--- 821
LVFL +Q+ + + Y LL L++FV + CV P L
Sbjct: 591 TFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLP 650
Query: 822 TLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNSRDLLGCLAQEHNISASQVNACHV 881
LS + +G TI LVF A ++F + C Q N+S+ N
Sbjct: 651 ALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSS--DCPFQAPNVSSMISN---- 704
Query: 882 AESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIEL 941
+++ L P Y + L L+CS+FL +S ++L
Sbjct: 705 ----LSWELPGSLPLISVP--------YSMHCCTLGFLSCSLFLHMS--------FELKL 744
Query: 942 IYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCPEHATKVALKVVTPIIISVFVLAL 1001
+ +L+ +LF ++ ++ I G K K++ I +F L
Sbjct: 745 LLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSRPGVLKEP-KLMGAISFFIFFFTL 803
Query: 1002 YLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDE 1061
+ A+Q E RLDFLWK + +E+EE E ++ R LL N+LP VA F+ + RRN++
Sbjct: 804 LVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNED 863
Query: 1062 LYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEK 1121
LY+QS ECV V+FAS+ +F EFY E N+EG+ECLRLLNEIIADFDE++S+ +F +EK
Sbjct: 864 LYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEK 923
Query: 1122 IKTIGSTYMAASGLN-----DSTYD-KVGKTHIKALADFAMKLMDQMKYINEHSFNNFQM 1175
IKTIGSTYMAA+GLN D+ D + +H+ + +FA+ L ++ IN+HSFNNF++
Sbjct: 924 IKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRL 983
Query: 1176 KIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQL 1235
++GLN GPVVAGVIGA+KPQYDIWGNTVNVASRM+STGV +IQVT + L + Y
Sbjct: 984 RVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTC 1043
Query: 1236 ECRGVVKVKGKGEMMTYFLN-----GGPP 1259
RGV+KVKGKG++ TYFLN GPP
Sbjct: 1044 YSRGVIKVKGKGQLCTYFLNTDLTRTGPP 1072
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 215 bits (547), Expect = 2e-55
Identities = 149/457 (32%), Positives = 218/457 (47%), Gaps = 55/457 (12%)
Query: 220 KFPSDKLERLYQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQL-----PYLAVL 274
KF S LE F Q + + CL+ + A +L P L L
Sbjct: 94 KFDSVNLEEACLERCFPQTQRRFRYALFYIGFACLLWSIYFAVHMRSRLIVMVAPALCFL 153
Query: 275 AAAVGVILIMAVLCNRAAFHQDHMGLACYALI-AVVLAVQVVGLLLPQPRSASEGIWWT- 332
VG L A H LA L+ A+ LA Q L R S + T
Sbjct: 154 LVCVGFFLF--TFTKLYARHYAWTSLALTLLVFALTLAAQFQVLTPVSGRGDSSNLTATA 211
Query: 333 ----------------VFFIYTIYTLLPVRMRAAVLSGVLLSALHLAIALRTNAQDQF-- 374
+ ++ +YT++ + + ++ GV S L + F
Sbjct: 212 RPTDTCLSQVGSFSMCIEVLFLLYTVMHLPLYLSLCLGVAYSVLFETFGYHFRDEACFPS 271
Query: 375 -----LLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARLHSQRENQQQE 429
L +L+S L+ C + +GV ++V R F + + I + E +E
Sbjct: 272 PGAGALHWELLSRGLLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKE 331
Query: 430 RLLLSVLPRHVAMEMKADINAKQEDMM-----------------------FHKIYIQKHD 466
R++ SV+PR +A ++ + + E+ + F +Q+ +
Sbjct: 332 RMIHSVMPRIIADDLMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIE 391
Query: 467 NVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGL 526
VSILFADI GFT +++ +A LV LN+LF RFD+L E C +I LGDCYYCV+G
Sbjct: 392 EVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAGC 451
Query: 527 PEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWS 586
PE RADHA+CC+EMG+ MI+AI + VNMRVG+H+G V CG+LG+R+++FDVWS
Sbjct: 452 PEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWS 511
Query: 587 NDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPG 623
NDV LAN ME G AG++HI++AT YL+ YE+E G
Sbjct: 512 NDVNLANLMEQLGVAGKVHISEATAKYLDDRYEMEDG 548
Score = 197 bits (502), Expect = 4e-50
Identities = 160/528 (30%), Positives = 266/528 (50%), Gaps = 46/528 (8%)
Query: 737 VRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTC 796
+ +F L F + +LE+ Y + V S V F P +L +L+
Sbjct: 747 INQFSLNFLDQELERSYRTSYQEE----VIKNSPVKTFAS-------PTFSSLLDVFLST 795
Query: 797 SLLLTLVVFVSVIYSCVKLFPSP--LQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMF 854
++ LTL + Y + P P L S ++ ++ + +I +VF V
Sbjct: 796 TVFLTLSTTCFLKYEAATVPPPPAALAVFSAALLLEVLSLAV----SIRMVFFLEDVMAC 851
Query: 855 TCNSRDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSV 914
T + + H I A V+ + AV + E N +FP + +
Sbjct: 852 TKRLLEWIAGWLPRHCIGAILVS---LPALAVYSHVTSEYE------TNIHFPVFTGSAA 902
Query: 915 LLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGT 974
L++++ F Q+S + L + +L++ V D++ L +A+ F++
Sbjct: 903 LIAVVHYCNFCQLSSWMRSSLATVVGAGPLLLLYVSLCP--DSSVLTSPLDAVQNFSSER 960
Query: 975 SQC----PEHATKVALKVVTPIIISVFVLAL--YLHAQQVESTARLDFLWKLQATEEKEE 1028
+ C P + A + +++ F+L L + ++ E + RL + ++A + +
Sbjct: 961 NPCNSSVPRDLRRPASLIGQEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTK 1020
Query: 1029 MEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELE 1088
++ ++ LL NI+P + +A + + + Y ++ + V+FASI NFSEFY E
Sbjct: 1021 IQSMRDQADWLLRNIIP-----YHVAEQLKVSQTYSKNHDSGGVIFASIVNFSEFY---E 1072
Query: 1089 ANNEG-VECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVG--K 1145
N EG EC R+LNE+I DFDE++S+ + +EKIKTIG+TYMAASGLN + +
Sbjct: 1073 ENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQ 1132
Query: 1146 THIKALADFAMKLMDQMKYINEHS-FNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVN 1204
H++ L +FA ++M + N + + NF++++G N GP+ AGVIG K YDIWG+TVN
Sbjct: 1133 EHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVN 1192
Query: 1205 VASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTY 1252
+ASRMD+TGV RIQV+ + Y+VL+ Y + RG V VKGKG+M TY
Sbjct: 1193 IASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTY 1240
Score = 85.5 bits (210), Expect = 3e-16
Identities = 72/290 (24%), Positives = 127/290 (43%), Gaps = 35/290 (12%)
Query: 401 EVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKI 460
EVS R + E R Q Q + LL +++P HVA ++K +
Sbjct: 1001 EVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYHVAEQLKVS-----------QT 1049
Query: 461 YIQKHDNVSILFADIEGFTSLASQCT--AQELVMTLNELFARFDKLAAE---NHCLRIKI 515
Y + HD+ ++FA I F+ + +E LNEL FD+L ++ + +IK
Sbjct: 1050 YSKNHDSGGVIFASIVNFSEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKT 1109
Query: 516 LGDCYYCVSGLPEARA-------DHAHCCVEMGMDMIEAIS-LVREVTGVNVNMRVGIHS 567
+G Y SGL A+A +H E +M+ + + N +RVG +
Sbjct: 1110 IGATYMAASGLNTAQAQDGSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNH 1169
Query: 568 GRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKAT---LNYLNGDYEVEPGC 624
G + GV+G K +D+W + V +A+ M+ G RI +++ + L+ + D++
Sbjct: 1170 GPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTV 1229
Query: 625 GGERNAYLKEHSIETFLILRCTQKR---KEEKAMIAKMNRQRTNSIGHNP 671
+ +K T+L +CT R + + ++ + Q SIG +P
Sbjct: 1230 NVKGKGQMK-----TYLYPKCTDHRVIPQHQLSISPDIRVQVDGSIGRSP 1274
Score = 80.9 bits (198), Expect = 7e-15
Identities = 60/281 (21%), Positives = 122/281 (43%), Gaps = 49/281 (17%)
Query: 1012 ARLDFLWKLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDE---------- 1061
+R FL Q+ +++E +A R++H+++P+ +A + + E
Sbjct: 306 SRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSVKRHATSS 365
Query: 1062 -------------------LYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNE 1102
Q E V+++FA I F++ + AN + LLN+
Sbjct: 366 PKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTK----MSANKSAHALVGLLND 421
Query: 1103 IIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQM 1162
+ FD + E + EKI T+G Y +G + D H + + ++ +
Sbjct: 422 LFGRFDRLCEETK---CEKISTLGDCYYCVAGCPEPRAD-----HAYCCIEMGLGMIKAI 473
Query: 1163 KYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVT- 1221
+ + M++G++ G V+ G++G R+ ++D+W N VN+A+ M+ GV ++ ++
Sbjct: 474 EQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISE 533
Query: 1222 ------TDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1256
D Y++ + + VV + KG + TY ++G
Sbjct: 534 ATAKYLDDRYEMEDGKVIERLGQSVVADQLKG-LKTYLISG 573
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 123 bits (308), Expect = 1e-27
Identities = 87/247 (35%), Positives = 132/247 (53%), Gaps = 27/247 (10%)
Query: 1025 EKEEMEELQAYNRR------LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIA 1078
EK E QAY LL+ ILP VA +R + + ++ + V + F+ I
Sbjct: 813 EKLVEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIV 868
Query: 1079 NFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDS 1138
F+ L A + ++ + LLN++ FD II D F + K++TIG YM SGL
Sbjct: 869 GFTA----LSAESTPMQVVTLLNDLYTCFDAII--DNF-DVYKVETIGDAYMVVSGLPGR 921
Query: 1139 TYDKVGKTHIKALADFAMKLMDQMKY--INEHSFNNFQMKIGLNIGPVVAGVIGARKPQY 1196
G+ H +A A+ L+D + I + +++IG++ GPV AGV+G + P+Y
Sbjct: 922 N----GQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRY 977
Query: 1197 DIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL-AANTYQLECRGVVKVKGKGEMMTYFLN 1255
++G+TVN ASRM+S G +I V++ L +QLE RG V++KGKG+M TY+L
Sbjct: 978 CLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLL 1037
Query: 1256 G---GPP 1259
G GPP
Sbjct: 1038 GERKGPP 1044
Score = 103 bits (258), Expect = 8e-22
Identities = 62/203 (30%), Positives = 113/203 (55%), Gaps = 15/203 (7%)
Query: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
E ++ E LL +LP VA ++K + E D+V+I F+DI GFT+L++
Sbjct: 826 EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSVTIYFSDIVGFTALSA 875
Query: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGM 542
+ T ++V LN+L+ FD + +++ +GD Y VSGLP HA M +
Sbjct: 876 ESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMAL 935
Query: 543 DMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 600
+++A+S +R + +R+G+H+G V GV+GL+ ++ ++ + V A+ ME+ G+
Sbjct: 936 ALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQ 995
Query: 601 AGRIHITKATLNYLN--GDYEVE 621
A +IH++ T + L+ G +++E
Sbjct: 996 ALKIHVSSTTKDALDELGCFQLE 1018
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 116 bits (291), Expect = 1e-25
Identities = 83/240 (34%), Positives = 128/240 (53%), Gaps = 25/240 (10%)
Query: 1024 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF 1083
E EE+E + RLL +LP VA E + Q V + F+ I F+
Sbjct: 837 ERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQ----VTLYFSDIVGFTT- 891
Query: 1084 YVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV 1143
+ A +E +E + LLN++ FD II + K++TIG YM ASGL
Sbjct: 892 ---ISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPQRN---- 941
Query: 1144 GKTHIKALADFAMKLMD-----QMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDI 1198
G+ H +A+ ++ ++ +M+++ E +++IGL+ GP VAGV+G P+Y +
Sbjct: 942 GQRHAAEIANMSLDILSAVGTFRMRHMPEVPV---RIRIGLHSGPCVAGVVGLTMPRYCL 998
Query: 1199 WGNTVNVASRMDSTGVPDRIQVTTDMYQVLAA--NTYQLECRGVVKVKGKGEMMTYFLNG 1256
+G+TVN ASRM+STG+P RI V +L A + YQ+E RG ++KGKG T++L G
Sbjct: 999 FGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVG 1058
Score = 100 bits (250), Expect = 7e-21
Identities = 63/204 (30%), Positives = 107/204 (52%), Gaps = 16/204 (7%)
Query: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
E Q+ +RLL +LP VA +K + E + V++ F+DI GFT++++
Sbjct: 845 EKQKTDRLLTQMLPPSVAEALKTGTPVEPEYF----------EQVTLYFSDIVGFTTISA 894
Query: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGM 542
E+V LN+L+ FD + + +++ +GD Y SGLP+ HA M +
Sbjct: 895 MSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSL 954
Query: 543 DMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 600
D++ A+ +R + V V +R+G+HSG GV+GL ++ ++ + V A+ ME+ G
Sbjct: 955 DILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1014
Query: 601 AGRIHITKAT---LNYLNGDYEVE 621
RIH+ +T L L+ Y+VE
Sbjct: 1015 PYRIHVNLSTVGILRALDSGYQVE 1038
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 116 bits (290), Expect = 2e-25
Identities = 79/236 (33%), Positives = 130/236 (55%), Gaps = 25/236 (10%)
Query: 1024 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF 1083
EEK + E L L+ ILP VA +R + + ++ + V + F+ I F+
Sbjct: 840 EEKRKAEAL-------LYQILPHSVAEQL----KRGETVQAEAFDSVTIYFSDIVGFTA- 887
Query: 1084 YVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV 1143
L A + ++ + LLN++ FD +I D F + K++TIG YM SGL
Sbjct: 888 ---LSAESTPMQVVTLLNDLYTCFDAVI--DNF-DVYKVETIGDAYMVVSGLPVRN---- 937
Query: 1144 GKTHIKALADFAMKLMDQMKY--INEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGN 1201
G+ H +A A+ L+D ++ I +++IG++ GPV AGV+G + P+Y ++G+
Sbjct: 938 GRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGD 997
Query: 1202 TVNVASRMDSTGVPDRIQVTTDMYQVLAA-NTYQLECRGVVKVKGKGEMMTYFLNG 1256
TVN ASRM+S G +I ++++ VL ++LE RG V++KGKG++ TY+L G
Sbjct: 998 TVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLG 1053
Score = 103 bits (257), Expect = 1e-21
Identities = 64/204 (31%), Positives = 111/204 (54%), Gaps = 17/204 (8%)
Query: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
E ++ E LL +LP VA ++K + E D+V+I F+DI GFT+L++
Sbjct: 841 EKRKAEALLYQILPHSVAEQLKRGETVQAEAF----------DSVTIYFSDIVGFTALSA 890
Query: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCC--VEMG 541
+ T ++V LN+L+ FD + +++ +GD Y VSGLP R H C M
Sbjct: 891 ESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLP-VRNGRLHACEVARMA 949
Query: 542 MDMIEAIS--LVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGG 599
+ +++A+ +R + +R+GIH+G V GV+GL+ ++ ++ + V A+ ME+ G
Sbjct: 950 LALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG 1009
Query: 600 KAGRIHITKATLNYLN--GDYEVE 621
+A +IH++ T L G +E+E
Sbjct: 1010 EALKIHLSSETKAVLEEFGGFELE 1033
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 115 bits (288), Expect = 3e-25
Identities = 79/240 (32%), Positives = 130/240 (54%), Gaps = 25/240 (10%)
Query: 1024 EEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEF 1083
E EE+E + +LL +LP VA ++ + + + V + F+ I F+
Sbjct: 841 ERTEELEIEKQKTEKLLTQMLPPSVAESL----KKGCTVEPEGFDLVTLYFSDIVGFTT- 895
Query: 1084 YVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKV 1143
+ A +E +E + LLN++ FD II + K++TIG YM ASGL
Sbjct: 896 ---ISAMSEPIEVVDLLNDLYTLFDAIIGS---HDVYKVETIGDAYMVASGLPKRN---- 945
Query: 1144 GKTHIKALADFAMKLMD-----QMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDI 1198
G H +A+ ++ ++ +M+++ E +++IGL+ GPVVAGV+G P+Y +
Sbjct: 946 GSRHAAEIANMSLDILSSVGTFKMRHMPEVPV---RIRIGLHSGPVVAGVVGLTMPRYCL 1002
Query: 1199 WGNTVNVASRMDSTGVPDRIQVTTDMYQVL--AANTYQLECRGVVKVKGKGEMMTYFLNG 1256
+G+TVN ASRM+STG+P RI V+ +L + Y++E RG ++KGKG T++L G
Sbjct: 1003 FGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIG 1062
Score = 103 bits (258), Expect = 8e-22
Identities = 65/204 (31%), Positives = 109/204 (53%), Gaps = 16/204 (7%)
Query: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
E Q+ E+LL +LP VA +K + E D V++ F+DI GFT++++
Sbjct: 849 EKQKTEKLLTQMLPPSVAESLKKGCTVEPEGF----------DLVTLYFSDIVGFTTISA 898
Query: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGM 542
E+V LN+L+ FD + + +++ +GD Y SGLP+ HA M +
Sbjct: 899 MSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSL 958
Query: 543 DMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 600
D++ ++ +R + V V +R+G+HSG V GV+GL ++ ++ + V A+ ME+ G
Sbjct: 959 DILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGL 1018
Query: 601 AGRIHITKAT---LNYLNGDYEVE 621
RIH++ +T L L+ YEVE
Sbjct: 1019 PYRIHVSLSTVTILQNLSEGYEVE 1042
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 110 bits (276), Expect = 6e-24
Identities = 64/199 (32%), Positives = 106/199 (53%), Gaps = 12/199 (6%)
Query: 418 RLHSQRENQQQER--LLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADI 475
R H E ++++ LL S+ P VA ++ ++ +K D+V++LF+DI
Sbjct: 478 RTHQALEEEKKKTVDLLYSIFPGDVAQQL----------WQGQQVQARKFDDVTMLFSDI 527
Query: 476 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
GFT++ +QCT +++ LNEL+ RFD +++ +GD Y +GL HA
Sbjct: 528 VGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAK 587
Query: 536 CCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 595
M + M+E V G + MR+GIHSG V GV+G+R ++ ++ N+VTLA+
Sbjct: 588 PIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKF 647
Query: 596 EAGGKAGRIHITKATLNYL 614
E+G RI+++ T L
Sbjct: 648 ESGSHPRRINVSPTTYQLL 666
Score = 95.5 bits (236), Expect = 3e-19
Identities = 64/212 (30%), Positives = 112/212 (52%), Gaps = 18/212 (8%)
Query: 1019 KLQATEEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFAS 1076
KL+AT E+ + +EE + LL++I P DVA + ++ + + V ++F+
Sbjct: 471 KLKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARKFDDVTMLFSD 526
Query: 1077 IANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLN 1136
I F+ + ++ + +LNE+ FD + F + K++TIG Y A+GL+
Sbjct: 527 IVGFTAICAQCTP----MQVISMLNELYTRFDH---QCGFLDIYKVETIGDAYCVAAGLH 579
Query: 1137 DSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQY 1196
+ H K +A A+K+M+ + + QM+IG++ G V+AGV+G R P+Y
Sbjct: 580 RKSL-----CHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRY 634
Query: 1197 DIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL 1228
++GN V +AS+ +S P RI V+ YQ+L
Sbjct: 635 CLFGNNVTLASKFESGSHPRRINVSPTTYQLL 666
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 106 bits (265), Expect = 1e-22
Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 10/199 (5%)
Query: 416 QARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADI 475
QA + E ++ LL S+ P VA ++ + +K NV++LF+DI
Sbjct: 203 QAHQALEEEKKKTVDLLCSIFPCEVAQQL----------WQGQVVQAKKFSNVTMLFSDI 252
Query: 476 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 253 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 312
Query: 536 CCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 595
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 313 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 372
Query: 596 EAGGKAGRIHITKATLNYL 614
E+ +I+++ T L
Sbjct: 373 ESCSVPRKINVSPTTYRLL 391
Score = 83.6 bits (205), Expect = 1e-15
Identities = 61/214 (28%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 1017 LWKLQATEEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 1074
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 194 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 249
Query: 1075 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASG 1134
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 250 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 302
Query: 1135 LNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKP 1194
L+ K TH +A A+K+M+ + +M+IGL+ G V AGV+G + P
Sbjct: 303 LH-----KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 357
Query: 1195 QYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL 1228
+Y ++GN V +A++ +S VP +I V+ Y++L
Sbjct: 358 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 391
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 106 bits (265), Expect = 1e-22
Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 10/199 (5%)
Query: 416 QARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADI 475
QA + E ++ LL S+ P VA ++ + +K NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL----------WQGQVVQAKKFSNVTMLFSDI 487
Query: 476 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
Query: 536 CCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 595
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 596 EAGGKAGRIHITKATLNYL 614
E+ +I+++ T L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626
Score = 83.6 bits (205), Expect = 1e-15
Identities = 61/214 (28%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 1017 LWKLQATEEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 1074
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
Query: 1075 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASG 1134
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
Query: 1135 LNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKP 1194
L+ K TH +A A+K+M+ + +M+IGL+ G V AGV+G + P
Sbjct: 538 LH-----KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
Query: 1195 QYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL 1228
+Y ++GN V +A++ +S VP +I V+ Y++L
Sbjct: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 106 bits (265), Expect = 1e-22
Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 10/199 (5%)
Query: 416 QARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADI 475
QA + E ++ LL S+ P VA ++ + +K NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL----------WQGQVVQAKKFSNVTMLFSDI 487
Query: 476 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
Query: 536 CCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 595
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 596 EAGGKAGRIHITKATLNYL 614
E+ +I+++ T L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626
Score = 83.6 bits (205), Expect = 1e-15
Identities = 61/214 (28%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 1017 LWKLQATEEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 1074
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
Query: 1075 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASG 1134
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
Query: 1135 LNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKP 1194
L+ K TH +A A+K+M+ + +M+IGL+ G V AGV+G + P
Sbjct: 538 LH-----KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
Query: 1195 QYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL 1228
+Y ++GN V +A++ +S VP +I V+ Y++L
Sbjct: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 106 bits (265), Expect = 1e-22
Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 10/199 (5%)
Query: 416 QARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADI 475
QA + E ++ LL S+ P VA ++ + +K NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL----------WQGQVVQAKKFSNVTMLFSDI 487
Query: 476 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
Query: 536 CCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 595
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 596 EAGGKAGRIHITKATLNYL 614
E+ +I+++ T L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626
Score = 83.6 bits (205), Expect = 1e-15
Identities = 61/214 (28%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 1017 LWKLQATEEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 1074
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
Query: 1075 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASG 1134
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
Query: 1135 LNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKP 1194
L+ K TH +A A+K+M+ + +M+IGL+ G V AGV+G + P
Sbjct: 538 LH-----KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
Query: 1195 QYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL 1228
+Y ++GN V +A++ +S VP +I V+ Y++L
Sbjct: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 106 bits (265), Expect = 1e-22
Identities = 61/199 (30%), Positives = 103/199 (51%), Gaps = 10/199 (5%)
Query: 416 QARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADI 475
QA + E ++ LL S+ P VA ++ + +K NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL----------WQGQVVQAKKFSNVTMLFSDI 487
Query: 476 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
Query: 536 CCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 595
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 596 EAGGKAGRIHITKATLNYL 614
E+ +I+++ T L
Sbjct: 608 ESCSVPRKINVSPTTYRLL 626
Score = 83.6 bits (205), Expect = 1e-15
Identities = 61/214 (28%), Positives = 107/214 (50%), Gaps = 18/214 (8%)
Query: 1017 LWKLQATEEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 1074
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
Query: 1075 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASG 1134
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
Query: 1135 LNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKP 1194
L+ K TH +A A+K+M+ + +M+IGL+ G V AGV+G + P
Sbjct: 538 LH-----KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
Query: 1195 QYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVL 1228
+Y ++GN V +A++ +S VP +I V+ Y++L
Sbjct: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYRLL 626
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 105 bits (263), Expect = 2e-22
Identities = 60/195 (30%), Positives = 102/195 (52%), Gaps = 10/195 (5%)
Query: 416 QARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADI 475
QA + E ++ LL S+ P VA ++ + +K NV++LF+DI
Sbjct: 438 QAHQALEEEKKKTVDLLCSIFPCEVAQQL----------WQGQVVQAKKFSNVTMLFSDI 487
Query: 476 EGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAH 535
GFT++ SQC+ +++ LN L+ RFD+ E +++ +GD Y GL + HA
Sbjct: 488 VGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAV 547
Query: 536 CCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHM 595
M + M+E V G + MR+G+HSG V GV+G++ ++ ++ N+VTLAN
Sbjct: 548 QIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKF 607
Query: 596 EAGGKAGRIHITKAT 610
E+ +I+++ T
Sbjct: 608 ESCSVPRKINVSPTT 622
Score = 81.6 bits (200), Expect = 4e-15
Identities = 60/212 (28%), Positives = 105/212 (49%), Gaps = 18/212 (8%)
Query: 1017 LWKLQATEEK--EEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMF 1074
L KL+AT E+ + +EE + LL +I P +VA + + + V ++F
Sbjct: 429 LGKLKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLW----QGQVVQAKKFSNVTMLF 484
Query: 1075 ASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASG 1134
+ I F+ + ++ + +LN + FD+ E + K++TIG Y A G
Sbjct: 485 SDIVGFTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGG 537
Query: 1135 LNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKP 1194
L+ K TH +A A+K+M+ + +M+IGL+ G V AGV+G + P
Sbjct: 538 LH-----KESDTHAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMP 592
Query: 1195 QYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQ 1226
+Y ++GN V +A++ +S VP +I V+ Y+
Sbjct: 593 RYCLFGNNVTLANKFESCSVPRKINVSPTTYR 624
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 103 bits (256), Expect = 1e-21
Identities = 68/208 (32%), Positives = 110/208 (52%), Gaps = 22/208 (10%)
Query: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHK--IYIQKHDNVSILFADIEGFTSL 481
E ++ + LL SVLP VA E++ HK + +++DNV+ILF+ I GF +
Sbjct: 386 EKKKTDTLLYSVLPPSVANELR------------HKRPVPAKRYDNVTILFSGIVGFNAF 433
Query: 482 ASQCT----AQELVMTLNELFARFDKLAAENH---CLRIKILGDCYYCVSGLPEARADHA 534
S+ A ++V LN+L+ RFD L +++ +GD Y VSGLPE HA
Sbjct: 434 CSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHA 493
Query: 535 HCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANH 594
+ +DM+E V +V G +V + +GIH+G V GV+G R ++ ++ N V L +
Sbjct: 494 RSICHLALDMMEIAGQV-QVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSR 552
Query: 595 MEAGGKAGRIHITKATLNYLNGDYEVEP 622
E G+ G+I++++ T L +P
Sbjct: 553 TETTGEKGKINVSEYTYRCLMSPENSDP 580
Score = 100 bits (250), Expect = 7e-21
Identities = 73/257 (28%), Positives = 130/257 (50%), Gaps = 19/257 (7%)
Query: 1006 QQVESTARLDFLW-KLQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYY 1064
++ + T L+ L +LQ T +E+ + LL+++LP VA R +
Sbjct: 361 EEYKLTQELEILTDRLQLT--LRALEDEKKKTDTLLYSVLPPSVANEL----RHKRPVPA 414
Query: 1065 QSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKT 1124
+ + V ++F+ I F+ F + + ++ + LLN++ FD + + + K++T
Sbjct: 415 KRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVET 474
Query: 1125 IGSTYMAASGLNDSTYDKVGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPV 1184
+G YM SGL + H +++ A+ +M+ + + Q+ IG++ G V
Sbjct: 475 VGDKYMTVSGLPEPCIH-----HARSICHLALDMMEIAGQVQVDG-ESVQITIGIHTGEV 528
Query: 1185 VAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDMYQVLAA-----NTYQLECRG 1239
V GVIG R P+Y ++GNTVN+ SR ++TG +I V+ Y+ L + + LE RG
Sbjct: 529 VTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRG 588
Query: 1240 VVKVKGKGE-MMTYFLN 1255
V +KGK E M +FL+
Sbjct: 589 PVSMKGKKEPMQVWFLS 605
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 99.8 bits (247), Expect = 1e-20
Identities = 72/223 (32%), Positives = 109/223 (48%), Gaps = 19/223 (8%)
Query: 1038 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 1097
RL +LP+ V + ELY E V + F+ I F+ + +E +
Sbjct: 795 RLNFMLLPRLVVKSLKEKGFVEPELY----EEVTIYFSDIVGFTTIC----KYSTPMEVV 846
Query: 1098 RLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMK 1157
+LN+I FD I+ + K++TIG YM ASGL G H +A A++
Sbjct: 847 DMLNDIYKSFDHIVDH---HDVYKVETIGDAYMVASGLPKRN----GNRHAIDIAKMALE 899
Query: 1158 LMDQMKYINEHSFNNFQM--KIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVP 1215
++ M + +IG++ GP AGV+G + P+Y ++G+TVN ASRM+STG+P
Sbjct: 900 ILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLP 959
Query: 1216 DRIQVTTDMYQVLAANTYQL--ECRGVVKVKGKGEMMTYFLNG 1256
RI V+ +L Q E RG +KG+G TY+L G
Sbjct: 960 LRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG 1002
Score = 91.7 bits (226), Expect = 4e-18
Identities = 63/224 (28%), Positives = 116/224 (51%), Gaps = 24/224 (10%)
Query: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
E + +RL +LPR V +K ++ + ++Y + V+I F+DI GFT++
Sbjct: 789 ERDRADRLNFMLLPRLVVKSLK------EKGFVEPELY----EEVTIYFSDIVGFTTICK 838
Query: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGM 542
T E+V LN+++ FD + + +++ +GD Y SGLP+ + HA +M +
Sbjct: 839 YSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMAL 898
Query: 543 DMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 600
+++ + + + G+ + +R+G+HSG GV+G++ ++ ++ + V A+ ME+ G
Sbjct: 899 EILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGL 958
Query: 601 AGRIHITKATLNYLNGD-----YEVEPGCGGERNAYLKEHSIET 639
RIH++ +T+ L YEV GE YLK ET
Sbjct: 959 PLRIHVSGSTIAILKRTECQFLYEVR----GE--TYLKGRGNET 996
>gi|153070260 myristoylated alanine-rich protein kinase C substrate
[Homo sapiens]
Length = 332
Score = 52.0 bits (123), Expect = 4e-06
Identities = 64/240 (26%), Positives = 92/240 (38%), Gaps = 65/240 (27%)
Query: 2 SGSKSVSPPGYAAQK---TAAPAPRGG--PEHRSAWGEADSRANGYPHAPGG---SARGS 53
+GS + SP AA+K AA AP G P + A E ++ G P A G SA S
Sbjct: 75 AGSGAASPS--AAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEGEAASAASS 132
Query: 54 TKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGR 113
T P +++D P S + P FSF+ G
Sbjct: 133 TSSP----------------KAEDGATPSPSNETPKKKKKRFSFKKSFKLS-------GF 169
Query: 114 GSRRQRRGAASGGSTRAPPAGGG-----GGSAAAAASAGGT------------------- 149
++ ++ A GG AP A GG GG+AAAAA AG
Sbjct: 170 SFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGA 229
Query: 150 ------EVRPRSVEVGLEE--RRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGA 201
E +P+ V E+ + +AA+E + E +G ++ ++ S AGPGA
Sbjct: 230 AGGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASAAACEAPSAAGPGA 289
Score = 31.2 bits (69), Expect = 6.5
Identities = 34/120 (28%), Positives = 46/120 (38%), Gaps = 17/120 (14%)
Query: 99 SKSAWQERG-----GD------DCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAG 147
SK+ QE G GD + G Q G+A P A G G ++ +AA G
Sbjct: 29 SKANGQENGHVKVNGDASPAAAESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKG 88
Query: 148 --GTEVRPRSVEVGLE-ERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLS 204
P + +E E +G AA E G+ EG +S+ S A GA S
Sbjct: 89 EPAAAAAPEAGASPVEKEAPAEGEAA---EPGSPTAAEGEAASAASSTSSPKAEDGATPS 145
>gi|223555958 transmembrane protein 64 isoform 1 [Homo sapiens]
Length = 380
Score = 49.7 bits (117), Expect = 2e-05
Identities = 86/316 (27%), Positives = 128/316 (40%), Gaps = 69/316 (21%)
Query: 120 RGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELE-AGAV 178
RGA G P GGG +AAAAA+A G ++ ER G A++ E GA+
Sbjct: 35 RGAGGDGPADRLPRGGGASAAAAAAAASG------ALLGAYLERHGPPEASELPEPGGAL 88
Query: 179 EGGEGSGDGGSSADSGSGAGPGAVLSLGACC---------LALLQIFRSKKFPSDKLERL 229
GG GSG GG G V + CC L L+ + + F S L R
Sbjct: 89 AGGPGSGGGGVV------VGVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRR 142
Query: 230 YQRYFFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAA------------ 277
Y + +S ++L +L +V ++++F P Y+ + AA
Sbjct: 143 YLHHLLLWVESLDSLLGVLLFVVGFIVVSF-----PCGWGYIVLNVAAGYLYGFVLGMGL 197
Query: 278 --VGVIL---IMAVLCNR------AAFHQDHMGLACYALIAVV-----LAVQVVGLLLPQ 321
VGV++ I V+C R AA Q L+ A+I VV L V + L P
Sbjct: 198 MMVGVLIGTFIAHVVCKRLLTAWVAARIQSSEKLS--AVIRVVEGGSGLKVVALARLTPI 255
Query: 322 PRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSAL---HLAIALRTNAQDQFLLKQ 378
P + F T +L M ++V G+L + L +L LRT + + +Q
Sbjct: 256 PFGLQNAV-----FSITDLSLPNYLMASSV--GLLPTQLLNSYLGTTLRT--MEDVIAEQ 306
Query: 379 LVSNVLIFSCTNIVGV 394
VS +F I+ +
Sbjct: 307 SVSGYFVFCLQIIISI 322
>gi|57864582 hornerin [Homo sapiens]
Length = 2850
Score = 49.7 bits (117), Expect = 2e-05
Identities = 49/184 (26%), Positives = 67/184 (36%), Gaps = 25/184 (13%)
Query: 33 GEADSRANGYPHAPGGS----ARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDP 88
G S+++GY GS +RG G + Q S W S SG
Sbjct: 1340 GSGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSS 1399
Query: 89 LAGGFGFSFRSKSAWQERG----GDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAA 144
GF S+WQ G G G S ++ G+ SG S+R G GS+++
Sbjct: 1400 -----GFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYG 1454
Query: 145 SAGGTEVRPRSVEVGLEERRGKGR--AADELEAGAVEGGEGSGDGGSSADSGSGAGPGAV 202
G G + G G+ + G GSG G SS+ S G+G G
Sbjct: 1455 QHGS----------GSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWS 1504
Query: 203 LSLG 206
S G
Sbjct: 1505 SSRG 1508
Score = 47.8 bits (112), Expect = 7e-05
Identities = 48/184 (26%), Positives = 66/184 (35%), Gaps = 25/184 (13%)
Query: 33 GEADSRANGYPHAPGGS----ARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDP 88
G S+++ Y GS +RG G + Q S W S SG
Sbjct: 2280 GSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSS 2339
Query: 89 LAGGFGFSFRSKSAWQERG----GDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAA 144
GF S+WQ G G G S ++ G+ SG S+R G GS+++
Sbjct: 2340 -----GFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGERHGSSSGSSSSYG 2394
Query: 145 SAGGTEVRPRSVEVGLEERRGKGR--AADELEAGAVEGGEGSGDGGSSADSGSGAGPGAV 202
G G + G G+ + G GSG G SS+ S G+G G
Sbjct: 2395 QHGS----------GSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYSPYGSGSGWS 2444
Query: 203 LSLG 206
S G
Sbjct: 2445 SSRG 2448
Score = 46.6 bits (109), Expect = 2e-04
Identities = 47/184 (25%), Positives = 65/184 (35%), Gaps = 25/184 (13%)
Query: 33 GEADSRANGYPHAPGGS----ARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDP 88
G S+++ Y GS +RG G + Q S W S SG
Sbjct: 1810 GSGSSQSSSYGQQGSGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGSGQSS 1869
Query: 89 LAGGFGFSFRSKSAWQERG----GDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAA 144
GF S+WQ G G G S ++ G+ SG S+R G GS+++
Sbjct: 1870 -----GFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRGEQHGSSSGSSSSYG 1924
Query: 145 SAGGTEVRPRSVEVGLEERRGKGR--AADELEAGAVEGGEGSGDGGSSADSGSGAGPGAV 202
G G + G G+ + G GSG G SS+ G+G G
Sbjct: 1925 QHGS----------GSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYGSGSGWS 1974
Query: 203 LSLG 206
S G
Sbjct: 1975 SSRG 1978
Score = 45.8 bits (107), Expect = 3e-04
Identities = 54/220 (24%), Positives = 78/220 (35%), Gaps = 26/220 (11%)
Query: 4 SKSVSPPGYAAQKTAAPAP-RGGPEHRSAWGEADSRA---NGY-----------PHAPGG 48
S S P GY + ++++ P G H S G +SR+ +GY H G
Sbjct: 555 SSSYGPHGYGSGRSSSRGPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHG 614
Query: 49 SARGSTKKPG--GAVTPQQ----QQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSA 102
S G + G GA + Q Q S S SG P G G F S+
Sbjct: 615 STSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSSS 674
Query: 103 WQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTE----VRPRSVEV 158
+ + G G S G+ SG S+ G G S+ + G+ R
Sbjct: 675 YGQHGSGS-GWSSSNGPHGSVSGQSSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRS 733
Query: 159 GLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAG 198
G R + ++ L + + G GS GSG+G
Sbjct: 734 GQSSRSEQHGSSSGLSSSYGQHGSGSHQSSGHGRQGSGSG 773
Score = 44.3 bits (103), Expect = 7e-04
Identities = 53/207 (25%), Positives = 77/207 (37%), Gaps = 24/207 (11%)
Query: 4 SKSVSPPGYAAQKTAAPAPRG-GPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
S S G ++ ++++ G G S +G S G +PG RGS G +
Sbjct: 2026 SSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGS---GSGQSPGHGQRGS----GSRQS 2078
Query: 63 PQQQQRLASRWRSDDDDDP-PLSGDDPLAGGFGF--SFRSKSAWQERGGDDCGRGSRRQR 119
P + + RS P G+ + GFG S +S+ + G G S +
Sbjct: 2079 PSYGRHGSGSGRSSSSGQHGPGLGE---SSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQ 2135
Query: 120 RGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVE 179
G+ SG S+R G GS++ G G + G GR
Sbjct: 2136 HGSRSGQSSRGERHGSSSGSSSRYGQHGS----------GSRQSSGHGRQGSGSGHSPSR 2185
Query: 180 GGEGSGDGGSSADSGSGAGPGAVLSLG 206
G GSG G SS+ G+G G S G
Sbjct: 2186 GRHGSGSGHSSSHGQHGSGSGRSSSRG 2212
Score = 43.5 bits (101), Expect = 0.001
Identities = 53/206 (25%), Positives = 72/206 (34%), Gaps = 28/206 (13%)
Query: 3 GSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
GS S P Y + + +H S GE+ +G+ H S + S+ G+
Sbjct: 1602 GSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGES----SGFGHHESSSGQSSSYSQHGS-- 1655
Query: 63 PQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGA 122
S S SG G S RS S + + G GSR+
Sbjct: 1656 -------GSGHSSGYGQHGSRSGQSSRGERHGSSSRSSSRYGQHGS-----GSRQSSGHG 1703
Query: 123 ASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAG--AVEG 180
G + P+ G GS +S+ G G R R E +G +V G
Sbjct: 1704 RQGSGSGQSPSRGRHGSGLGHSSSHGQH--------GSGSGRSSSRGPYESRSGHSSVFG 1755
Query: 181 GEGSGDGGSSADSGSGAGPGAVLSLG 206
SG G SSA S G+G G S G
Sbjct: 1756 QHESGSGHSSAYSQHGSGSGHFCSQG 1781
Score = 43.1 bits (100), Expect = 0.002
Identities = 54/206 (26%), Positives = 73/206 (35%), Gaps = 15/206 (7%)
Query: 3 GSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
GS S PG+ + + + H S G + S P S G + G +
Sbjct: 2059 GSGSGQSPGHGQRGSGSRQSPSYGRHGSGSGRSSSSGQHGPGLGESSGFGHHESSSGQSS 2118
Query: 63 PQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGA 122
Q S S SG G S S S + + G + S R+G+
Sbjct: 2119 SYSQHGSGSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSRYGQHGSGS-RQSSGHGRQGS 2177
Query: 123 ASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAG--AVEG 180
SG S P+ G GS + +S+ G G R R E +G +V G
Sbjct: 2178 GSGHS----PSRGRHGSGSGHSSSHGQH--------GSGSGRSSSRGPYESRSGHSSVFG 2225
Query: 181 GEGSGDGGSSADSGSGAGPGAVLSLG 206
SG G SSA S G+G G S G
Sbjct: 2226 QHESGSGHSSAYSQHGSGSGHFCSQG 2251
Score = 43.1 bits (100), Expect = 0.002
Identities = 50/201 (24%), Positives = 74/201 (36%), Gaps = 19/201 (9%)
Query: 2 SGSKSVSPPGYAAQKTAAPAPRGGPE----HRSAWGEADSRANGYPHAPGGSARGSTKKP 57
SGS S G + + RG E H S +G+ +S G H+ S GS
Sbjct: 2190 SGSGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHES---GSGHSSAYSQHGSGS-- 2244
Query: 58 GGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRR 117
G Q Q S S D + +G G G S++ ++G G+ R
Sbjct: 2245 -GHFCSQGQHGSTSGQSSTFDQEGSSTGQSSSHGQHGSGSSQSSSYGQQGSGS-GQSPSR 2302
Query: 118 QRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGA 177
R G+ SG S+ G G G ++++ G G G ++ +G
Sbjct: 2303 GRHGSGSGHSSSYGQHGSGSGWSSSSGRHGSGS--------GQSSGFGHHESSSWQSSGY 2354
Query: 178 VEGGEGSGDGGSSADSGSGAG 198
+ G GSG S GS +G
Sbjct: 2355 TQHGSGSGHSSSYEQHGSRSG 2375
Score = 42.4 bits (98), Expect = 0.003
Identities = 49/204 (24%), Positives = 72/204 (35%), Gaps = 18/204 (8%)
Query: 4 SKSVSPPGYAAQKTAAPAPRG-GPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
S S G ++ ++++ G G S +G S G +PG RGS G +
Sbjct: 2496 SSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGS---GSGQSPGHGQRGS----GSRQS 2548
Query: 63 PQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGA 122
P + + RS + G S +S+ + G G S + G+
Sbjct: 2549 PSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGS 2608
Query: 123 ASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGE 182
SG S+R G GS++ G G + G GR G
Sbjct: 2609 RSGQSSRGERHGSSSGSSSHYGQHGS----------GSRQSSGHGRQGSGSGQSPSRGRH 2658
Query: 183 GSGDGGSSADSGSGAGPGAVLSLG 206
GSG G SS+ G+G G S G
Sbjct: 2659 GSGLGHSSSHGQHGSGSGRSSSRG 2682
Score = 42.0 bits (97), Expect = 0.004
Identities = 51/205 (24%), Positives = 73/205 (35%), Gaps = 24/205 (11%)
Query: 3 GSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
GS S S Y + + G +H S G++ S + G GS + S+ P G+
Sbjct: 1914 GSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRG--RHGSGSGQSSSYGPYGS-- 1969
Query: 63 PQQQQRLASRWRSDDDDDPPLSGDDPLAG-GFGFSFRSKSAWQERGGDDCGRGSRRQRRG 121
S W S P SG +G G S +S+ + G G S + G
Sbjct: 1970 -------GSGWSSSRG--PYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHG 2020
Query: 122 AASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGG 181
+ASG S+ G G +++ G G + G GR G
Sbjct: 2021 SASGQSSSCGQHGASSGQSSSHGQHGS----------GSSQSSGYGRQGSGSGQSPGHGQ 2070
Query: 182 EGSGDGGSSADSGSGAGPGAVLSLG 206
GSG S + G+G G S G
Sbjct: 2071 RGSGSRQSPSYGRHGSGSGRSSSSG 2095
Score = 41.6 bits (96), Expect = 0.005
Identities = 45/171 (26%), Positives = 65/171 (38%), Gaps = 15/171 (8%)
Query: 28 HRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDD 87
H S +G+ +S G H+ S GS G Q Q S S D + +G
Sbjct: 1280 HSSVFGQHES---GSGHSSAYSQHGSGS---GHFCSQGQHGSTSGQSSTFDQEGSSTGQS 1333
Query: 88 PLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAG 147
G G S S+S+ R G G+ R R G+ SG S+ G G G ++++ G
Sbjct: 1334 SSYGHRG-SGSSQSSGYGRHGAGSGQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHG 1392
Query: 148 GTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAG 198
G G ++ +G + G GSG S GS +G
Sbjct: 1393 SGS--------GQSSGFGHHESSSWQSSGCTQHGSGSGHSSSYEQHGSRSG 1435
Score = 41.2 bits (95), Expect = 0.006
Identities = 49/209 (23%), Positives = 75/209 (35%), Gaps = 19/209 (9%)
Query: 3 GSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
GS S S Y + + G +H S G++ S + G GS + S+ P G+ +
Sbjct: 1444 GSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRG--RHGSGSGQSSSYSPYGSGS 1501
Query: 63 PQQQQRLASRWRSDDDDDPPLSGDDPLAG---GFGF--SFRSKSAWQERGGDDCGRGSRR 117
R + S L + +G G+G S S+ + G G+ S
Sbjct: 1502 GWSSSR--GPYESGSSHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSC 1559
Query: 118 QRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGA 177
+ GA+SG S+ G G ++ G G + G G+
Sbjct: 1560 GQHGASSGQSSSHGQHGSGSSQSSGYGRQGS----------GSGQSPGHGQRGSGSRQSP 1609
Query: 178 VEGGEGSGDGGSSADSGSGAGPGAVLSLG 206
G GSG G SS+ G+G G G
Sbjct: 1610 SYGRHGSGSGRSSSSGQHGSGLGESSGFG 1638
Score = 40.8 bits (94), Expect = 0.008
Identities = 49/204 (24%), Positives = 71/204 (34%), Gaps = 30/204 (14%)
Query: 21 APRGGPEHRSAWGEADSRANGYPHAPGGS----ARGSTKKPGGAVTPQQQQRLASRWRSD 76
A G G S+++ Y GS +RG G + Q S W S
Sbjct: 628 ATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSSSYGQHGSGSGWSSS 687
Query: 77 DDDDPPLSGDDPLAGGFGF--------------SFRSKSAWQERGGDDCGRGSRRQRRGA 122
+ +SG + GFG S S S+ + G G+ SR ++ G+
Sbjct: 688 NGPHGSVSGQ---SSGFGHKSGSGQSSGYSQHGSGSSHSSGYRKHGSRSGQSSRSEQHGS 744
Query: 123 ASGGSTRAPPAGGGGGSAAAAASAG-GTEVRPRSVEVGLEE-------RRGKGRAADELE 174
+SG S+ G G ++ G G+ P V G + G G +
Sbjct: 745 SSGLSSSYGQHGSGSHQSSGHGRQGSGSGHSPSRVRHGSSSGHSSSHGQHGSGTSCSS-S 803
Query: 175 AGAVEGGEGSGDGGSSADSGSGAG 198
G E G G G +SGSG G
Sbjct: 804 CGHYESGSGQASGFGQHESGSGQG 827
Score = 40.8 bits (94), Expect = 0.008
Identities = 42/171 (24%), Positives = 64/171 (37%), Gaps = 15/171 (8%)
Query: 28 HRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDD 87
H S +G+ +S G H+ S GS G Q Q S S D + +G
Sbjct: 1750 HSSVFGQHES---GSGHSSAYSQHGSGS---GHFCSQGQHGSTSGQSSTFDQEGSSTGQS 1803
Query: 88 PLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAG 147
G G S++ ++G G+ R R G+ SG S+ G G G ++++ G
Sbjct: 1804 SSHGQHGSGSSQSSSYGQQGSGS-GQSPSRGRHGSGSGHSSSYGQHGSGSGWSSSSGRHG 1862
Query: 148 GTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAG 198
G G ++ +G + G GSG S GS +G
Sbjct: 1863 SGS--------GQSSGFGHHESSSWQSSGYTQHGSGSGHSSSYEQHGSRSG 1905
Score = 40.8 bits (94), Expect = 0.008
Identities = 49/209 (23%), Positives = 75/209 (35%), Gaps = 19/209 (9%)
Query: 3 GSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
GS S S Y + + G +H S G++ S + G GS + S+ P G+ +
Sbjct: 2384 GSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRG--RHGSGSGQSSSYSPYGSGS 2441
Query: 63 PQQQQRLASRWRSDDDDDPPLSGDDPLAG---GFGF--SFRSKSAWQERGGDDCGRGSRR 117
R + S L + +G G+G S S+ + G G+ S
Sbjct: 2442 GWSSSR--GPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTSGQSSSC 2499
Query: 118 QRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGA 177
+ GA+SG S+ G G ++ G G + G G+
Sbjct: 2500 GQHGASSGQSSSHGQHGSGSSQSSGYGRQGS----------GSGQSPGHGQRGSGSRQSP 2549
Query: 178 VEGGEGSGDGGSSADSGSGAGPGAVLSLG 206
G GSG G SS+ G+G G G
Sbjct: 2550 SYGRHGSGSGRSSSSGQHGSGLGESSGFG 2578
Score = 40.0 bits (92), Expect = 0.014
Identities = 54/214 (25%), Positives = 79/214 (36%), Gaps = 32/214 (14%)
Query: 3 GSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADS---RANGYPHAPGGSARGSTKKPGG 59
GS S GY + + G HRS+ G + S +G + G +GS G
Sbjct: 248 GSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSSYGQHGSGSRQSLGHGRQGS----GS 303
Query: 60 AVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQR 119
+P + + S S G +S+ S+ ++ G G G
Sbjct: 304 RQSPSHVRHGSGSGHS--------SSHGQHGSGSSYSY-SRGHYESGSGQTSGFGQHESG 354
Query: 120 RGAASG------GSTRAPPAGGGGGSAAAAASAG--GTEVRPRSVEVGLEE---RRGKGR 168
G +SG GS + G G ++ A+S+G G+ R +S G E R GR
Sbjct: 355 SGQSSGYSKHGSGSGHSSSQGQHGSTSGQASSSGQHGSSSR-QSSSYGQHESASRHSSGR 413
Query: 169 AADELEAGAVEG----GEGSGDGGSSADSGSGAG 198
+G G G GSG SS G+G G
Sbjct: 414 GQHSSGSGQSPGHGQRGSGSGQSPSSGQHGTGFG 447
Score = 40.0 bits (92), Expect = 0.014
Identities = 55/225 (24%), Positives = 78/225 (34%), Gaps = 46/225 (20%)
Query: 3 GSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
GS S Y ++A+ G +H S G++ PG RGS G +
Sbjct: 391 GSSSRQSSSYGQHESASRHSSGRGQHSSGSGQS----------PGHGQRGS----GSGQS 436
Query: 63 PQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGF---SFRSKSAWQERG------------ 107
P Q RS P +SG + GFG S S + + G
Sbjct: 437 PSSGQHGTGFGRSSSSG-PYVSGSG-YSSGFGHHESSSEHSSGYTQHGSGSGHSSGHGQH 494
Query: 108 GDDCGRGSRRQRRGAASGGSTRAPPAG------------GGGGSAAAAASAGGTEVRPRS 155
G G+ SR +R+G+++G S+ G G G + + S G E R
Sbjct: 495 GSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHESGSRQ 554
Query: 156 VEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPG 200
G GR++ G E G G G +S SG G
Sbjct: 555 SSSYGPHGYGSGRSSSR---GPYESGSGHSSGLGHQESRSGQSSG 596
Score = 40.0 bits (92), Expect = 0.014
Identities = 51/204 (25%), Positives = 71/204 (34%), Gaps = 24/204 (11%)
Query: 3 GSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
GS S P Y + + +H S GE+ +G+ H S + S+ G+
Sbjct: 2542 GSGSRQSPSYGRHGSGSGRSSSSGQHGSGLGES----SGFGHHESSSGQSSSYSQHGS-- 2595
Query: 63 PQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGA 122
S S SG G S S S + + G + S R+G+
Sbjct: 2596 -------GSGHSSGYGQHGSRSGQSSRGERHGSSSGSSSHYGQHGSGS-RQSSGHGRQGS 2647
Query: 123 ASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGE 182
SG S G G G +++ G R S +G L +V G
Sbjct: 2648 GSGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSS----------RGPYESRLGHSSVFGQH 2697
Query: 183 GSGDGGSSADSGSGAGPGAVLSLG 206
SG G SSA S G+G G S G
Sbjct: 2698 ESGSGHSSAYSQHGSGSGHFCSQG 2721
Score = 39.7 bits (91), Expect = 0.018
Identities = 48/204 (23%), Positives = 71/204 (34%), Gaps = 18/204 (8%)
Query: 4 SKSVSPPGYAAQKTAAPAPRG-GPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
S S G ++ ++++ G G S +G S G +PG RGS G +
Sbjct: 1556 SSSCGQHGASSGQSSSHGQHGSGSSQSSGYGRQGS---GSGQSPGHGQRGS----GSRQS 1608
Query: 63 PQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGA 122
P + + RS + G S +S+ + G G S + G+
Sbjct: 1609 PSYGRHGSGSGRSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGS 1668
Query: 123 ASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGE 182
SG S+R G S++ G G + G GR G
Sbjct: 1669 RSGQSSRGERHGSSSRSSSRYGQHGS----------GSRQSSGHGRQGSGSGQSPSRGRH 1718
Query: 183 GSGDGGSSADSGSGAGPGAVLSLG 206
GSG G SS+ G+G G S G
Sbjct: 1719 GSGLGHSSSHGQHGSGSGRSSSRG 1742
Score = 38.9 bits (89), Expect = 0.031
Identities = 45/184 (24%), Positives = 60/184 (32%), Gaps = 19/184 (10%)
Query: 27 EHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGD 86
+H S G++ S + S RG G Q S S +D SG
Sbjct: 168 QHNSYSGQSSSYGEQNSDSHQSSGRGQCGSGSGQSPNYGQHGSGSGQSSSNDTHGSGSGQ 227
Query: 87 DPLAGGFGFSFRSKSAWQERG----GDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAA 142
GFS S+ Q G G G S + G+ SG S+R GS+++
Sbjct: 228 SS-----GFSQHKSSSGQSSGYSQHGSGSGHSSGYGQHGSRSGQSSRGERHRSSSGSSSS 282
Query: 143 AASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAV 202
G G + G GR GSG G SS+ G+G
Sbjct: 283 YGQHGS----------GSRQSLGHGRQGSGSRQSPSHVRHGSGSGHSSSHGQHGSGSSYS 332
Query: 203 LSLG 206
S G
Sbjct: 333 YSRG 336
Score = 38.9 bits (89), Expect = 0.031
Identities = 48/208 (23%), Positives = 78/208 (37%), Gaps = 17/208 (8%)
Query: 3 GSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVT 62
GS + S Y + + G H S G++ S + G + GS + S+ P G +
Sbjct: 508 GSSAGSSSSYGQHGSGSRQSLGHSRHGSGSGQSPSPSRGRHES--GSRQSSSYGPHGYGS 565
Query: 63 PQQQQRLASRWRSDDDDDPPLSGDDPLAG-GFGFSFRSKSAWQERGGDDCGRGSRRQRRG 121
+ R P SG +G G S +S+ + G G S + G
Sbjct: 566 GRSSSR-----------GPYESGSGHSSGLGHQESRSGQSSGYGQHGSSSGHSSTHGQHG 614
Query: 122 AASGGSTRAPPAGGGGGSAAAAASAG-GTEVRPRSVEVGLEERRG--KGRAADELEAGAV 178
+ SG S+ G G +++ G G+ R + G + +GR + +
Sbjct: 615 STSGQSSSCGQHGATSGQSSSHGQHGSGSSQSSRYGQQGSGSGQSPSRGRHGSDFGHSSS 674
Query: 179 EGGEGSGDGGSSADSGSGAGPGAVLSLG 206
G GSG G SS++ G+ G G
Sbjct: 675 YGQHGSGSGWSSSNGPHGSVSGQSSGFG 702
Score = 38.9 bits (89), Expect = 0.031
Identities = 48/206 (23%), Positives = 70/206 (33%), Gaps = 13/206 (6%)
Query: 3 GSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGG--SARGSTKKPGGA 60
GS S S Y + + G +H S G++ S + G + G S+ G + G
Sbjct: 974 GSSSGSSSSYGQHGSGSRQSLGHGQHGSGSGQSPSPSRGRHGSGSGQSSSYGPYRSGSGW 1033
Query: 61 VTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRR 120
+ + S S SG G G S S + G G+ S +
Sbjct: 1034 SSSRGPYESGSGHSSGLGHRESRSGQSSGYGQHGSSSGHSSTHGQHGSTS-GQSSSCGQH 1092
Query: 121 GAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEG 180
GA+SG S+ G G ++ G G + G G+ G
Sbjct: 1093 GASSGQSSSHGQHGSGSSQSSGYGRQGS----------GSGQSPGHGQRGSGSRQSPSYG 1142
Query: 181 GEGSGDGGSSADSGSGAGPGAVLSLG 206
GSG G SS+ G+G G G
Sbjct: 1143 RHGSGSGRSSSSGQHGSGLGESSGFG 1168
Score = 38.5 bits (88), Expect = 0.041
Identities = 45/184 (24%), Positives = 67/184 (36%), Gaps = 31/184 (16%)
Query: 27 EHRSAWGEADSRA---NGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPL 83
+H SA A R +G +PG RGS G +P + + RS
Sbjct: 869 QHESASHHASGRGRHGSGSGQSPGHGQRGS----GSGQSPSYGRHGSGSGRSSSSGRHGS 924
Query: 84 SGDDPLAGGFGFSFRS-KSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAA 142
+ GFG S +S+ + G G S ++ G+ SG S+R+ G GS+++
Sbjct: 925 GSGQ--SSGFGHKSSSGQSSGYTQHGSGSGHSSSYEQHGSRSGQSSRSEQHGSSSGSSSS 982
Query: 143 AASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAV 202
G G + G G + G GSG S + G+G G
Sbjct: 983 YGQHGS----------GSRQSLGHG-----------QHGSGSGQSPSPSRGRHGSGSGQS 1021
Query: 203 LSLG 206
S G
Sbjct: 1022 SSYG 1025
Score = 38.1 bits (87), Expect = 0.053
Identities = 50/195 (25%), Positives = 68/195 (34%), Gaps = 30/195 (15%)
Query: 25 GPEHRSAWGEADSRANGYPHAPGGSARGSTK-KPGGAVTPQQQQRLASRWRSDDDDDPPL 83
G H S +G+ SR+ G S+RG G+ + Q SR S
Sbjct: 2596 GSGHSSGYGQHGSRS-------GQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSG 2648
Query: 84 SGDDPLAGGFGFSFRSKSAWQERG---GDDCGRGSRRQRRG---------AASGGSTRAP 131
SG P G G S+ + G G RG R G + SG S+
Sbjct: 2649 SGQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHSSVFGQHESGSGHSSAYS 2708
Query: 132 PAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSA 191
G G G + G T + + + +E G+++ G GSG SS
Sbjct: 2709 QHGSGSGHFCSQGQHGSTSGQSSTFD---QEGSSTGQSSSY-------GHRGSGSSQSSG 2758
Query: 192 DSGSGAGPGAVLSLG 206
GAG G LS G
Sbjct: 2759 YGRHGAGSGQSLSHG 2773
Score = 37.4 bits (85), Expect = 0.091
Identities = 55/222 (24%), Positives = 77/222 (34%), Gaps = 40/222 (18%)
Query: 21 APRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDD 80
A G G S+++GY G GS + PG ++ S R
Sbjct: 1094 ASSGQSSSHGQHGSGSSQSSGY----GRQGSGSGQSPGHGQRGSGSRQSPSYGRHGSGSG 1149
Query: 81 PPLSGDDPLAG-----GFGF---SFRSKSAWQERG------------GDDCGRGSRRQRR 120
S +G GFG S S++ + G G G+ SR +R
Sbjct: 1150 RSSSSGQHGSGLGESSGFGHHESSSGQSSSYSQHGSGSGHSSGYGQHGSRSGQSSRGERH 1209
Query: 121 GAASGGSTRAPPAGGG----GGSAAAAASAGGTEVRPR----------SVEVGLEERRGK 166
G++SG S+ G G G + +G + R R + G R
Sbjct: 1210 GSSSGSSSHYGQHGSGSRQSSGHGRQGSGSGHSPSRGRHGSGLGHSSSHGQHGSGSGRSS 1269
Query: 167 GRAADELEAG--AVEGGEGSGDGGSSADSGSGAGPGAVLSLG 206
R E +G +V G SG G SSA S G+G G S G
Sbjct: 1270 SRGPYESRSGHSSVFGQHESGSGHSSAYSQHGSGSGHFCSQG 1311
Score = 35.8 bits (81), Expect = 0.27
Identities = 49/195 (25%), Positives = 67/195 (34%), Gaps = 30/195 (15%)
Query: 25 GPEHRSAWGEADSRANGYPHAPGGSARGSTK-KPGGAVTPQQQQRLASRWRSDDDDDPPL 83
G H S +G+ SR+ G S+RG G+ + Q SR S
Sbjct: 1186 GSGHSSGYGQHGSRS-------GQSSRGERHGSSSGSSSHYGQHGSGSRQSSGHGRQGSG 1238
Query: 84 SGDDPLAGGFGFSFRSKSAWQERG---GDDCGRGSRRQRRG---------AASGGSTRAP 131
SG P G G S+ + G G RG R G + SG S+
Sbjct: 1239 SGHSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYS 1298
Query: 132 PAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSA 191
G G G + G T + + + +E G+++ G GSG SS
Sbjct: 1299 QHGSGSGHFCSQGQHGSTSGQSSTFD---QEGSSTGQSSSY-------GHRGSGSSQSSG 1348
Query: 192 DSGSGAGPGAVLSLG 206
GAG G S G
Sbjct: 1349 YGRHGAGSGQSPSRG 1363
Score = 35.8 bits (81), Expect = 0.27
Identities = 50/198 (25%), Positives = 70/198 (35%), Gaps = 36/198 (18%)
Query: 25 GPEHRSAWGEADSRAN----GYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDD 80
G H S +G+ SR+ G H GS+ GS+ + G Q SR S
Sbjct: 2126 GSGHSSGYGQHGSRSGQSSRGERH---GSSSGSSSRYG-------QHGSGSRQSSGHGRQ 2175
Query: 81 PPLSGDDPLAGGFGFSFRSKSAWQERG---GDDCGRGSRRQRRG---------AASGGST 128
SG P G G S+ + G G RG R G + SG S+
Sbjct: 2176 GSGSGHSPSRGRHGSGSGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSS 2235
Query: 129 RAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGG 188
G G G + G T + + + +E G+++ G GSG
Sbjct: 2236 AYSQHGSGSGHFCSQGQHGSTSGQSSTFD---QEGSSTGQSSSH-------GQHGSGSSQ 2285
Query: 189 SSADSGSGAGPGAVLSLG 206
SS+ G+G G S G
Sbjct: 2286 SSSYGQQGSGSGQSPSRG 2303
Score = 34.7 bits (78), Expect = 0.59
Identities = 46/194 (23%), Positives = 66/194 (34%), Gaps = 28/194 (14%)
Query: 25 GPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLS 84
G H S +G+ SR+ + G GS+ + Q SR S S
Sbjct: 1656 GSGHSSGYGQHGSRSG---QSSRGERHGSSSRSSSRYG---QHGSGSRQSSGHGRQGSGS 1709
Query: 85 GDDPLAGGFGFSFRSKSAWQERG---GDDCGRGSRRQRRG---------AASGGSTRAPP 132
G P G G S+ + G G RG R G + SG S+
Sbjct: 1710 GQSPSRGRHGSGLGHSSSHGQHGSGSGRSSSRGPYESRSGHSSVFGQHESGSGHSSAYSQ 1769
Query: 133 AGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSAD 192
G G G + G T + + + +E G+++ G GSG SS+
Sbjct: 1770 HGSGSGHFCSQGQHGSTSGQSSTFD---QEGSSTGQSSSH-------GQHGSGSSQSSSY 1819
Query: 193 SGSGAGPGAVLSLG 206
G+G G S G
Sbjct: 1820 GQQGSGSGQSPSRG 1833
Score = 33.5 bits (75), Expect = 1.3
Identities = 48/221 (21%), Positives = 76/221 (34%), Gaps = 21/221 (9%)
Query: 2 SGSKSVSPPGYAAQKTAAPAPRG----GPEHRSAWGEADS---RANGYPHAPGGSARGST 54
SGS S G ++ RG G S +G+ +S +++GY GS S+
Sbjct: 314 SGSGHSSSHGQHGSGSSYSYSRGHYESGSGQTSGFGQHESGSGQSSGYSKHGSGSGHSSS 373
Query: 55 KKPGGAVTPQ--------QQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQER 106
+ G+ + Q R +S + + SG + G G +S +
Sbjct: 374 QGQHGSTSGQASSSGQHGSSSRQSSSYGQHESASRHSSGRGQHSSGSG-----QSPGHGQ 428
Query: 107 GGDDCGRGSRRQRRGAASGGSTRAPP-AGGGGGSAAAAASAGGTEVRPRSVEVGLEERRG 165
G G+ + G G S+ + P G G S+ +E + G
Sbjct: 429 RGSGSGQSPSSGQHGTGFGRSSSSGPYVSGSGYSSGFGHHESSSEHSSGYTQHGSGSGHS 488
Query: 166 KGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLG 206
G +G GE G S+ S G G+ SLG
Sbjct: 489 SGHGQHGSRSGQSSRGERQGSSAGSSSSYGQHGSGSRQSLG 529
Score = 32.7 bits (73), Expect = 2.2
Identities = 31/117 (26%), Positives = 43/117 (36%), Gaps = 10/117 (8%)
Query: 90 AGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGT 149
A GFG + G G S + R G+ SG S+ + G S++ +S+ G
Sbjct: 814 ASGFGQHESGSGQGYSQHGSASGHFSSQGRHGSTSGQSS----SSGQHDSSSGQSSSYGQ 869
Query: 150 EVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLG 206
E G+GR G GSG G S + G+G G S G
Sbjct: 870 H------ESASHHASGRGRHGSGSGQSPGHGQRGSGSGQSPSYGRHGSGSGRSSSSG 920
Score = 32.0 bits (71), Expect = 3.8
Identities = 48/199 (24%), Positives = 68/199 (34%), Gaps = 26/199 (13%)
Query: 2 SGSKSVSPPGYAAQKTAAPAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAV 61
SGS+ S G + RG H S G + S + S+RG + G
Sbjct: 2634 SGSRQSSGHGRQGSGSGQSPSRG--RHGSGLGHSSSHGQHGSGSGRSSSRGPYESRLGHS 2691
Query: 62 TPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRG 121
+ Q S S SG G G S +S+ ++ G G+ S RG
Sbjct: 2692 SVFGQHESGSGHSSAYSQHGSGSGHFCSQGQHG-STSGQSSTFDQEGSSTGQSSSYGHRG 2750
Query: 122 AASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGG 181
+ S S+ G G G + + G G G+++ G
Sbjct: 2751 SGSSQSSGYGRHGAGSGQSLSHGRHGS----------------GSGQSSSY-------GQ 2787
Query: 182 EGSGDGGSSADSGSGAGPG 200
GSG G SS S G+G G
Sbjct: 2788 HGSGSGQSSGYSQHGSGSG 2806
>gi|226371762 transmembrane protein 64 isoform 2 [Homo sapiens]
Length = 328
Score = 48.1 bits (113), Expect = 5e-05
Identities = 45/150 (30%), Positives = 66/150 (44%), Gaps = 22/150 (14%)
Query: 120 RGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRGKGRAADELE-AGAV 178
RGA G P GGG +AAAAA+A G ++ ER G A++ E GA+
Sbjct: 35 RGAGGDGPADRLPRGGGASAAAAAAAASG------ALLGAYLERHGPPEASELPEPGGAL 88
Query: 179 EGGEGSGDGGSSADSGSGAGPGAVLSLGACC---------LALLQIFRSKKFPSDKLERL 229
GG GSG GG G V + CC L L+ + + F S L R
Sbjct: 89 AGGPGSGGGGVV------VGVAEVRNWRCCCLGSTCWCRSLVLVCVLAALCFASLALVRR 142
Query: 230 YQRYFFRLNQSSLTMLMAVLVLVCLVMLAF 259
Y + +S ++L +L +V ++++F
Sbjct: 143 YLHHLLLWVESLDSLLGVLLFVVGFIVVSF 172
>gi|22748877 basic helix-loop-helix domain containing, class B, 5
[Homo sapiens]
Length = 381
Score = 47.4 bits (111), Expect = 9e-05
Identities = 63/210 (30%), Positives = 78/210 (37%), Gaps = 33/210 (15%)
Query: 8 SPPGYAAQKTAAPAPRGGPEHRSA-----WGEADSRANGY----PHAPGGSARGSTKKPG 58
+PPG + AP PR P S+ + AD G P GG + GS G
Sbjct: 38 TPPGM--DLSLAPPPRERPASSSSSPLGCFEPADPEGAGLLLPPPGGGGGGSAGSGGGGG 95
Query: 59 GAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKSAWQERGG------DDCG 112
G V + S D L L +G S S + GG D G
Sbjct: 96 GGVGVPGLL-VGSAGVGGDPSLSSLPAGAALCLKYGESASRGSVAESSGGEQSPDDDSDG 154
Query: 113 RGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASA-----GGTEVRPRSVEVGLEERRGKG 167
R R G A RA P GGGG+ AA + GG V P + G G G
Sbjct: 155 RCELVLRAGVAD---PRASPGAGGGGAKAAEGCSNAHLHGGASVPPGGLGGG-----GGG 206
Query: 168 RAADELEAGAVEGGEGSGDGGSSADSGSGA 197
++ G GG GSG GGSS+ S S +
Sbjct: 207 GSSSGSSGGG--GGSGSGSGGSSSSSSSSS 234
>gi|119395750 keratin 1 [Homo sapiens]
Length = 644
Score = 44.7 bits (104), Expect = 6e-04
Identities = 33/94 (35%), Positives = 39/94 (41%), Gaps = 5/94 (5%)
Query: 106 RGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSVEVGLEERRG 165
RGG G GS G SGG + +GGGGG + +GG+ G G
Sbjct: 518 RGGGGGGYGSGGSSYG--SGGGSYG--SGGGGGGGRGSYGSGGSSYGSGGGSYGSGGGGG 573
Query: 166 -KGRAADELEAGAVEGGEGSGDGGSSADSGSGAG 198
G +G GG G G GGSS GSG G
Sbjct: 574 GHGSYGSGSSSGGYRGGSGGGGGGSSGGRGSGGG 607
Score = 42.7 bits (99), Expect = 0.002
Identities = 37/121 (30%), Positives = 46/121 (38%), Gaps = 11/121 (9%)
Query: 97 FRSKSAWQERGGDDCGRGS--RRQRRGAAS------GGSTRAPPAGGGGGSAAAAASAGG 148
F S+S ++ GG G QRR +S GG R GGGGGS A G
Sbjct: 5 FSSRSGYRSGGGFSSGSAGIINYQRRTTSSSTRRSGGGGGRFSSCGGGGGSFGAGGGFGS 64
Query: 149 TEV--RPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAVLSLG 206
+ S + + RG GR + G GG G G G G G G G G
Sbjct: 65 RSLVNLGGSKSISISVARGGGRGSG-FGGGYGGGGFGGGGFGGGGFGGGGIGGGGFGGFG 123
Query: 207 A 207
+
Sbjct: 124 S 124
Score = 37.7 bits (86), Expect = 0.070
Identities = 32/107 (29%), Positives = 40/107 (37%), Gaps = 28/107 (26%)
Query: 91 GGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTE 150
G G S+ S GG G GS G++SGG R GGGGGS+ S GG+
Sbjct: 553 GSGGSSYGSGGGSYGSGGGGGGHGSYGS--GSSSGGY-RGGSGGGGGGSSGGRGSGGGS- 608
Query: 151 VRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGA 197
+G GG GS GG + GS +
Sbjct: 609 ------------------------SGGSIGGRGSSSGGVKSSGGSSS 631
Score = 31.2 bits (69), Expect = 6.5
Identities = 44/166 (26%), Positives = 58/166 (34%), Gaps = 19/166 (11%)
Query: 37 SRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFS 96
S +GY + GG + GS G + Q++ +S RS G GG G S
Sbjct: 6 SSRSGY-RSGGGFSSGSA----GIINYQRRTTSSSTRRSGGG-----GGRFSSCGGGGGS 55
Query: 97 FRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGSAAAAASAGGTEVRPRSV 156
F + + R + G GS+ A GG + GG GG GG +
Sbjct: 56 FGAGGGFGSRSLVNLG-GSKSISISVARGGGRGSGFGGGYGGGGFGGGGFGGGGFGGGGI 114
Query: 157 EVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPGAV 202
G G G G GG G G GG G PG +
Sbjct: 115 GGGGFGGFGSG--------GGGFGGGGFGGGGYGGGYGPVCPPGGI 152
>gi|25777671 protein phosphatase 1, regulatory subunit 10 [Homo
sapiens]
Length = 940
Score = 44.7 bits (104), Expect = 6e-04
Identities = 50/172 (29%), Positives = 55/172 (31%), Gaps = 32/172 (18%)
Query: 42 YPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDDDPPLSGDDPLAGGFGFSFRSKS 101
+P PGG G PGG V P RL PP G DP G G R
Sbjct: 643 FPPGPGGPMPGPHGGPGGPVGP----RLLG-------PPPPPRGGDPFWDGPGDPMRGGP 691
Query: 102 AWQERGGDDCGRGSRRQRRGAASGGSTRAPP----------AGGG---GGSAAAAASAGG 148
RGG G G + RG G PP +GGG G GG
Sbjct: 692 M---RGGPGPGPGPYHRGRGGRGGNEPPPPPPPFRGARGGRSGGGPPNGRGGPGGGMVGG 748
Query: 149 TEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAGPG 200
RP G G G ++ GG GSG GS G G
Sbjct: 749 GGHRPHEGPGG-----GMGNSSGHRPHEGPGGGMGSGHRPHEGPGGSMGGGG 795
Score = 33.5 bits (75), Expect = 1.3
Identities = 45/179 (25%), Positives = 53/179 (29%), Gaps = 20/179 (11%)
Query: 20 PAPRGGPEHRSAWGEADSRANGYPHAPGGSARGSTKKPGGAVTPQQQQRLASRWRSDDDD 79
P P GP HR G R P P RG+ G P +
Sbjct: 696 PGPGPGPYHRGRGG----RGGNEPPPPPPPFRGARGGRSGGGPPNGRGGPGGGMVGGGGH 751
Query: 80 DPPLSGDDPLAGGFGFSFRSKSAWQERGGDDCGRGSRRQRRGAASGGSTRAPPAGGGGGS 139
P + GG G S + GG G G+ GG P G GGG
Sbjct: 752 RP----HEGPGGGMGNSSGHRPHEGPGGGMGSGHRPHEGPGGSMGGGGGHRPHEGPGGG- 806
Query: 140 AAAAASAGGTEVRPRSVEVGLEERRGKGRAADELEAGAVEGGEGSGDGGSSADSGSGAG 198
+GG+ RP G G R + GG G GG G G G
Sbjct: 807 -----ISGGSGHRPHEGPGGGMGAGGGHRPHEG------PGGSMGGSGGHRPHEGPGHG 854
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,342,848
Number of Sequences: 37866
Number of extensions: 2205323
Number of successful extensions: 17074
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 100
Number of HSP's successfully gapped in prelim test: 429
Number of HSP's that attempted gapping in prelim test: 12693
Number of HSP's gapped (non-prelim): 2710
length of query: 1261
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1147
effective length of database: 13,930,794
effective search space: 15978620718
effective search space used: 15978620718
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.