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Search of human proteins with 33356177
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
(593 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|33356177 protein tyrosine phosphatase, non-receptor type 11 [... 1219 0.0
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is... 656 0.0
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is... 654 0.0
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is... 654 0.0
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 211 2e-54
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 211 2e-54
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 211 2e-54
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 210 3e-54
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 210 3e-54
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 209 4e-54
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 209 6e-54
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 202 9e-52
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 202 9e-52
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 199 5e-51
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 199 5e-51
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 198 1e-50
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 196 5e-50
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 196 5e-50
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 196 5e-50
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 196 5e-50
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 196 5e-50
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 196 7e-50
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 196 7e-50
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 196 7e-50
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 196 7e-50
gi|157952215 protein tyrosine phosphatase, receptor type, B isof... 192 1e-48
gi|157952213 protein tyrosine phosphatase, receptor type, B isof... 192 1e-48
gi|4506289 protein tyrosine phosphatase, non-receptor type 1 [Ho... 189 6e-48
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 189 6e-48
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 189 6e-48
>gi|33356177 protein tyrosine phosphatase, non-receptor type 11
[Homo sapiens]
Length = 593
Score = 1219 bits (3153), Expect = 0.0
Identities = 593/593 (100%), Positives = 593/593 (100%)
Query: 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
Sbjct: 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60
Query: 61 DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK 120
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
Sbjct: 61 DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK 120
Query: 121 EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD 180
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
Sbjct: 121 EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD 180
Query: 181 VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT 240
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
Sbjct: 181 VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT 240
Query: 241 DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP 300
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
Sbjct: 241 DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP 300
Query: 301 VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV 360
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
Sbjct: 301 VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV 360
Query: 361 ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF 420
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF
Sbjct: 361 ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHF 420
Query: 421 RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR 480
RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR
Sbjct: 421 RTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIR 480
Query: 481 EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH 540
EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH
Sbjct: 481 EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGH 540
Query: 541 EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 593
EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR
Sbjct: 541 EYTNIKYSLADQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQKSFR 593
>gi|18104991 protein tyrosine phosphatase, non-receptor type 6
isoform 2 [Homo sapiens]
Length = 597
Score = 656 bits (1693), Expect = 0.0
Identities = 321/548 (58%), Positives = 412/548 (75%), Gaps = 6/548 (1%)
Query: 1 MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG 60
M SR WFH +++G++AE LL RGV GSFLARPS+ N GDF+LSVR VTHI+IQN+G
Sbjct: 1 MLSRGWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSG 60
Query: 61 DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK 120
D+YDLYGGEKFATL ELV+YY + G L++++G +I LKYPLNC+DPTSERW+HGH+SG
Sbjct: 61 DFYDLYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGG 120
Query: 121 EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKS-KVTHVMIRCQELKY 179
+AE LL KG+ +FLVRES S PGDFVLSV + D+ ++ G +VTH+ + C+ +Y
Sbjct: 121 QAETLLQAKGEPWTFLVRESLSQPGDFVLSVLS--DQPKAGPGSPLRVTHIKVMCEGGRY 178
Query: 180 DVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAET 239
VGG E FDSLTDLVEH+KK + E G + L+QP TR+NAA+IE+RV EL+K E+
Sbjct: 179 TVGGLETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQES 238
Query: 240 TDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNE 299
D K GFWEEFE+LQ+QE K L+ R EGQR ENK KNRYKNILPFDH+RV+L D N
Sbjct: 239 EDTAKAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNI 298
Query: 300 PVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKE 359
P SDYINAN I + N+K +YIA+QGCL+ TVNDFW+M +QENSRVIVMTT+E
Sbjct: 299 PGSDYINANYIKNQLLGPDENAK---TYIASQGCLEATVNDFWQMAWQENSRVIVMTTRE 355
Query: 360 VERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYH 419
VE+G++KCV YWP+ + YG V N E +Y LR L++S + G+ R +W Y
Sbjct: 356 VEKGRNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQ 415
Query: 420 FRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDII 479
+ +WPDHGVPS+PGGVL FL++++ +QES+ AGP++VHCSAGIGRTGT IVID+L++ I
Sbjct: 416 YLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENI 475
Query: 480 REKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKG 539
KG+DCDID+ KTIQMVR+QRSGMVQTEAQY+FIY+A+ +IET ++++E Q K +
Sbjct: 476 STKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQE 535
Query: 540 HEYTNIKY 547
EY NI Y
Sbjct: 536 SEYGNITY 543
>gi|18104993 protein tyrosine phosphatase, non-receptor type 6
isoform 3 [Homo sapiens]
Length = 624
Score = 654 bits (1687), Expect = 0.0
Identities = 319/544 (58%), Positives = 410/544 (75%), Gaps = 6/544 (1%)
Query: 5 RWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYD 64
RWFH +++G++AE LL RGV GSFLARPS+ N GDF+LSVR VTHI+IQN+GD+YD
Sbjct: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62
Query: 65 LYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEK 124
LYGGEKFATL ELV+YY + G L++++G +I LKYPLNC+DPTSERW+HGH+SG +AE
Sbjct: 63 LYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAET 122
Query: 125 LLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKS-KVTHVMIRCQELKYDVGG 183
LL KG+ +FLVRES S PGDFVLSV + D+ ++ G +VTH+ + C+ +Y VGG
Sbjct: 123 LLQAKGEPWTFLVRESLSQPGDFVLSVLS--DQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180
Query: 184 GERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKV 243
E FDSLTDLVEH+KK + E G + L+QP TR+NAA+IE+RV EL+K E+ D
Sbjct: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240
Query: 244 KQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSD 303
K GFWEEFE+LQ+QE K L+ R EGQR ENK KNRYKNILPFDH+RV+L D N P SD
Sbjct: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300
Query: 304 YINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG 363
YINAN I + N+K +YIA+QGCL+ TVNDFW+M +QENSRVIVMTT+EVE+G
Sbjct: 301 YINANYIKNQLLGPDENAK---TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKG 357
Query: 364 KSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTW 423
++KCV YWP+ + YG V N E +Y LR L++S + G+ R +W Y + +W
Sbjct: 358 RNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSW 417
Query: 424 PDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKG 483
PDHGVPS+PGGVL FL++++ +QES+ AGP++VHCSAGIGRTGT IVID+L++ I KG
Sbjct: 418 PDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477
Query: 484 VDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYT 543
+DCDID+ KTIQMVR+QRSGMVQTEAQY+FIY+A+ +IET ++++E Q K + EY
Sbjct: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYG 537
Query: 544 NIKY 547
NI Y
Sbjct: 538 NITY 541
Score = 68.2 bits (165), Expect = 2e-11
Identities = 43/119 (36%), Positives = 65/119 (54%), Gaps = 16/119 (13%)
Query: 2 TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNG---------AVT 52
TS RW+H +++G +AE LL +G +FL R S S PGDF LSV + VT
Sbjct: 106 TSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165
Query: 53 HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYP-----LNCAD 106
HIK+ G Y + G E F +L +LV+++ + ++E +G + L+ P +N AD
Sbjct: 166 HIKVMCEGGRYTVGGLETFDSLTDLVEHFKK--TGIEEASGAFVYLRQPYYATRVNAAD 222
>gi|18104989 protein tyrosine phosphatase, non-receptor type 6
isoform 1 [Homo sapiens]
Length = 595
Score = 654 bits (1687), Expect = 0.0
Identities = 319/544 (58%), Positives = 410/544 (75%), Gaps = 6/544 (1%)
Query: 5 RWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYD 64
RWFH +++G++AE LL RGV GSFLARPS+ N GDF+LSVR VTHI+IQN+GD+YD
Sbjct: 3 RWFHRDLSGLDAETLLKGRGVHGSFLARPSRKNQGDFSLSVRVGDQVTHIRIQNSGDFYD 62
Query: 65 LYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEK 124
LYGGEKFATL ELV+YY + G L++++G +I LKYPLNC+DPTSERW+HGH+SG +AE
Sbjct: 63 LYGGEKFATLTELVEYYTQQQGVLQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAET 122
Query: 125 LLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKS-KVTHVMIRCQELKYDVGG 183
LL KG+ +FLVRES S PGDFVLSV + D+ ++ G +VTH+ + C+ +Y VGG
Sbjct: 123 LLQAKGEPWTFLVRESLSQPGDFVLSVLS--DQPKAGPGSPLRVTHIKVMCEGGRYTVGG 180
Query: 184 GERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKV 243
E FDSLTDLVEH+KK + E G + L+QP TR+NAA+IE+RV EL+K E+ D
Sbjct: 181 LETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTA 240
Query: 244 KQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSD 303
K GFWEEFE+LQ+QE K L+ R EGQR ENK KNRYKNILPFDH+RV+L D N P SD
Sbjct: 241 KAGFWEEFESLQKQEVKNLHQRLEGQRPENKGKNRYKNILPFDHSRVILQGRDSNIPGSD 300
Query: 304 YINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG 363
YINAN I + N+K +YIA+QGCL+ TVNDFW+M +QENSRVIVMTT+EVE+G
Sbjct: 301 YINANYIKNQLLGPDENAK---TYIASQGCLEATVNDFWQMAWQENSRVIVMTTREVEKG 357
Query: 364 KSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTW 423
++KCV YWP+ + YG V N E +Y LR L++S + G+ R +W Y + +W
Sbjct: 358 RNKCVPYWPEVGMQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREIWHYQYLSW 417
Query: 424 PDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKG 483
PDHGVPS+PGGVL FL++++ +QES+ AGP++VHCSAGIGRTGT IVID+L++ I KG
Sbjct: 418 PDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMENISTKG 477
Query: 484 VDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYT 543
+DCDID+ KTIQMVR+QRSGMVQTEAQY+FIY+A+ +IET ++++E Q K + EY
Sbjct: 478 LDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQKGQESEYG 537
Query: 544 NIKY 547
NI Y
Sbjct: 538 NITY 541
Score = 68.2 bits (165), Expect = 2e-11
Identities = 43/119 (36%), Positives = 65/119 (54%), Gaps = 16/119 (13%)
Query: 2 TSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNG---------AVT 52
TS RW+H +++G +AE LL +G +FL R S S PGDF LSV + VT
Sbjct: 106 TSERWYHGHMSGGQAETLLQAKGEPWTFLVRESLSQPGDFVLSVLSDQPKAGPGSPLRVT 165
Query: 53 HIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYP-----LNCAD 106
HIK+ G Y + G E F +L +LV+++ + ++E +G + L+ P +N AD
Sbjct: 166 HIKVMCEGGRYTVGGLETFDSLTDLVEHFKK--TGIEEASGAFVYLRQPYYATRVNAAD 222
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 211 bits (536), Expect = 2e-54
Identities = 126/324 (38%), Positives = 185/324 (57%), Gaps = 24/324 (7%)
Query: 203 VETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLL 262
VE L + P + ++ E+++ +K+ F EEF L C +
Sbjct: 191 VEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL---FREEFNALPA--CPIQ 245
Query: 263 YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSK 322
+ + ++ENK KNRY NILP+DH+RV L + P SDYINA+ I N +
Sbjct: 246 ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVE-GVPDSDYINASFI--------NGYQ 296
Query: 323 PKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGV 382
K +IA QG + TVNDFWRM++++N+ IVM T ER + KC +YWPD+ YG
Sbjct: 297 EKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ-GCWTYGN 355
Query: 383 MRVRNVKESAAHDYTLRELKLSKVG---QGNTERTVWQYHFRTWPDHGVPSDPGGVLDFL 439
+RV + DYT+R+ + +VG +R + Q+HF +WPD GVP P G+L FL
Sbjct: 356 IRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFL 415
Query: 440 EEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRS 499
++V K + AG +VVHCSAG+GRTGTF+VID ++D++ + +DV + +R+
Sbjct: 416 KKV--KACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMH---TERKVDVYGFVSRIRA 470
Query: 500 QRSGMVQTEAQYRFIYMA-VQHYI 522
QR MVQT+ QY FIY A ++HY+
Sbjct: 471 QRCQMVQTDMQYVFIYQALLEHYL 494
Score = 184 bits (466), Expect = 3e-46
Identities = 106/308 (34%), Positives = 176/308 (57%), Gaps = 24/308 (7%)
Query: 219 TRINAAEIESRVREL-SKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKN 277
T + +E+ ++++ +K+ T++ + +++ +++ Q K+ + G N KN
Sbjct: 498 TELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKM----RTGNLPANMKKN 553
Query: 278 RYKNILPFDHTRVVL--HDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQ 335
R I+P++ RV++ G+ N +DY+NA+ I + + K SYIA+QG L
Sbjct: 554 RVLQIIPYEFNRVIIPVKRGEEN---TDYVNASFI--------DGYRQKDSYIASQGPLL 602
Query: 336 NTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHD 395
+T+ DFWRM+++ S IVM T+ ERG+ KC +YWP + L YG + V KE
Sbjct: 603 HTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECES 661
Query: 396 YTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPV 455
YT+R+L ++ + N R + Q+HF WP+ G+PSD G++ + V KQ+ P+
Sbjct: 662 YTVRDLLVTNTRE-NKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-QKQQQQSGNHPI 719
Query: 456 VVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIY 515
VHCSAG GRTGTF + +++ ++ +G+ +DV +T++ +R QR MVQT QY F Y
Sbjct: 720 TVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCY 776
Query: 516 MAVQHYIE 523
VQ YI+
Sbjct: 777 KVVQEYID 784
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 211 bits (536), Expect = 2e-54
Identities = 126/324 (38%), Positives = 185/324 (57%), Gaps = 24/324 (7%)
Query: 203 VETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLL 262
VE L + P + ++ E+++ +K+ F EEF L C +
Sbjct: 200 VEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL---FREEFNALPA--CPIQ 254
Query: 263 YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSK 322
+ + ++ENK KNRY NILP+DH+RV L + P SDYINA+ I N +
Sbjct: 255 ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVE-GVPDSDYINASFI--------NGYQ 305
Query: 323 PKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGV 382
K +IA QG + TVNDFWRM++++N+ IVM T ER + KC +YWPD+ YG
Sbjct: 306 EKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ-GCWTYGN 364
Query: 383 MRVRNVKESAAHDYTLRELKLSKVG---QGNTERTVWQYHFRTWPDHGVPSDPGGVLDFL 439
+RV + DYT+R+ + +VG +R + Q+HF +WPD GVP P G+L FL
Sbjct: 365 IRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFL 424
Query: 440 EEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRS 499
++V K + AG +VVHCSAG+GRTGTF+VID ++D++ + +DV + +R+
Sbjct: 425 KKV--KACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMH---TERKVDVYGFVSRIRA 479
Query: 500 QRSGMVQTEAQYRFIYMA-VQHYI 522
QR MVQT+ QY FIY A ++HY+
Sbjct: 480 QRCQMVQTDMQYVFIYQALLEHYL 503
Score = 184 bits (466), Expect = 3e-46
Identities = 106/308 (34%), Positives = 176/308 (57%), Gaps = 24/308 (7%)
Query: 219 TRINAAEIESRVREL-SKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKN 277
T + +E+ ++++ +K+ T++ + +++ +++ Q K+ + G N KN
Sbjct: 507 TELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKM----RTGNLPANMKKN 562
Query: 278 RYKNILPFDHTRVVL--HDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQ 335
R I+P++ RV++ G+ N +DY+NA+ I + + K SYIA+QG L
Sbjct: 563 RVLQIIPYEFNRVIIPVKRGEEN---TDYVNASFI--------DGYRQKDSYIASQGPLL 611
Query: 336 NTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHD 395
+T+ DFWRM+++ S IVM T+ ERG+ KC +YWP + L YG + V KE
Sbjct: 612 HTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECES 670
Query: 396 YTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPV 455
YT+R+L ++ + N R + Q+HF WP+ G+PSD G++ + V KQ+ P+
Sbjct: 671 YTVRDLLVTNTRE-NKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-QKQQQQSGNHPI 728
Query: 456 VVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIY 515
VHCSAG GRTGTF + +++ ++ +G+ +DV +T++ +R QR MVQT QY F Y
Sbjct: 729 TVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCY 785
Query: 516 MAVQHYIE 523
VQ YI+
Sbjct: 786 KVVQEYID 793
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 211 bits (536), Expect = 2e-54
Identities = 126/324 (38%), Positives = 185/324 (57%), Gaps = 24/324 (7%)
Query: 203 VETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLL 262
VE L + P + ++ E+++ +K+ F EEF L C +
Sbjct: 191 VEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKL---FREEFNALPA--CPIQ 245
Query: 263 YSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSK 322
+ + ++ENK KNRY NILP+DH+RV L + P SDYINA+ I N +
Sbjct: 246 ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVE-GVPDSDYINASFI--------NGYQ 296
Query: 323 PKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGV 382
K +IA QG + TVNDFWRM++++N+ IVM T ER + KC +YWPD+ YG
Sbjct: 297 EKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ-GCWTYGN 355
Query: 383 MRVRNVKESAAHDYTLRELKLSKVG---QGNTERTVWQYHFRTWPDHGVPSDPGGVLDFL 439
+RV + DYT+R+ + +VG +R + Q+HF +WPD GVP P G+L FL
Sbjct: 356 IRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFL 415
Query: 440 EEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRS 499
++V K + AG +VVHCSAG+GRTGTF+VID ++D++ + +DV + +R+
Sbjct: 416 KKV--KACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMH---TERKVDVYGFVSRIRA 470
Query: 500 QRSGMVQTEAQYRFIYMA-VQHYI 522
QR MVQT+ QY FIY A ++HY+
Sbjct: 471 QRCQMVQTDMQYVFIYQALLEHYL 494
Score = 184 bits (466), Expect = 3e-46
Identities = 106/308 (34%), Positives = 176/308 (57%), Gaps = 24/308 (7%)
Query: 219 TRINAAEIESRVREL-SKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKN 277
T + +E+ ++++ +K+ T++ + +++ +++ Q K+ + G N KN
Sbjct: 498 TELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKM----RTGNLPANMKKN 553
Query: 278 RYKNILPFDHTRVVL--HDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQ 335
R I+P++ RV++ G+ N +DY+NA+ I + + K SYIA+QG L
Sbjct: 554 RVLQIIPYEFNRVIIPVKRGEEN---TDYVNASFI--------DGYRQKDSYIASQGPLL 602
Query: 336 NTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHD 395
+T+ DFWRM+++ S IVM T+ ERG+ KC +YWP + L YG + V KE
Sbjct: 603 HTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECES 661
Query: 396 YTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPV 455
YT+R+L ++ + N R + Q+HF WP+ G+PSD G++ + V KQ+ P+
Sbjct: 662 YTVRDLLVTNTRE-NKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV-QKQQQQSGNHPI 719
Query: 456 VVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIY 515
VHCSAG GRTGTF + +++ ++ +G+ +DV +T++ +R QR MVQT QY F Y
Sbjct: 720 TVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCY 776
Query: 516 MAVQHYIE 523
VQ YI+
Sbjct: 777 KVVQEYID 784
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 210 bits (534), Expect = 3e-54
Identities = 120/275 (43%), Positives = 171/275 (62%), Gaps = 24/275 (8%)
Query: 246 GFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRV--VLHDGDPNEPVSD 303
GF EE+E L + + + KE EN+NKNRY NI+ +DH+RV ++ DGDP+ SD
Sbjct: 888 GFKEEYEALPEGQTASWDTAKE---DENRNKNRYGNIISYDHSRVRLLVLDGDPH---SD 941
Query: 304 YINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG 363
YINAN I + + YIATQG +Q TV DFWRM++QENS IVM T VE G
Sbjct: 942 YINANYI--------DGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVG 993
Query: 364 KSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTW 423
+ KCV+YWPD+ + YG ++V ++ +Y +R + K G + R + +HF +W
Sbjct: 994 RVKCVRYWPDD--TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGY-HEIRELRLFHFTSW 1050
Query: 424 PDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKG 483
PDHGVP G+L F+ +V K + +AGP+VVHCSAG GRTG FI ID ++D+ +G
Sbjct: 1051 PDHGVPCYATGLLGFVRQV--KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEG 1108
Query: 484 VDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
V +D+ ++ +R+QR +VQTE QY F++ A+
Sbjct: 1109 V---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1140
Score = 105 bits (262), Expect = 1e-22
Identities = 88/316 (27%), Positives = 149/316 (47%), Gaps = 34/316 (10%)
Query: 219 TRINAAEIESRVRELSKLAETTDKVKQGFWEEFETL-------QQQECKLLYSRKEGQRQ 271
T I E S +S+L T+ + +EF+TL + ++C + G
Sbjct: 1149 TAIPVCEFRSLYYNISRLDPQTNSSQ--IKDEFQTLNIVTPRVRPEDCSI------GLLP 1200
Query: 272 ENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQ 331
N +KNR ++LP D L D S+YINA ++ ++ K +++ TQ
Sbjct: 1201 RNHDKNRSMDVLPLDRCLPFLISVDGES--SNYINAALM--------DSHKQPAAFVVTQ 1250
Query: 332 GCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKES 391
L NTV DFWR+VF N +VM E++ + C++YWP++ + YG ++V V
Sbjct: 1251 HPLPNTVADFWRLVFDYNCSSVVM-LNEMDTAQF-CMQYWPEKTS-GCYGPIQVEFVSAD 1307
Query: 392 AAHDYTLRELKLSKVGQ-GNTERTVWQYHFRTWPDH-GVPSDPGGVLDFLEEVHHKQESI 449
D R ++ + + + R V + WP + P +L + + QE
Sbjct: 1308 IDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQY 1367
Query: 450 MD-AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTE 508
G VVHC G GR+GTF I + ++I+++ + IDV ++ +R+ +S MV+T
Sbjct: 1368 DGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNI---IDVFHIVKTLRNNKSNMVETL 1424
Query: 509 AQYRFIYMAVQHYIET 524
QY+F+Y Y+ +
Sbjct: 1425 EQYKFVYEVALEYLSS 1440
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 210 bits (534), Expect = 3e-54
Identities = 120/275 (43%), Positives = 171/275 (62%), Gaps = 24/275 (8%)
Query: 246 GFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRV--VLHDGDPNEPVSD 303
GF EE+E L + + + KE EN+NKNRY NI+ +DH+RV ++ DGDP+ SD
Sbjct: 907 GFKEEYEALPEGQTASWDTAKE---DENRNKNRYGNIISYDHSRVRLLVLDGDPH---SD 960
Query: 304 YINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG 363
YINAN I + + YIATQG +Q TV DFWRM++QENS IVM T VE G
Sbjct: 961 YINANYI--------DGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVG 1012
Query: 364 KSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTW 423
+ KCV+YWPD+ + YG ++V ++ +Y +R + K G + R + +HF +W
Sbjct: 1013 RVKCVRYWPDD--TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGY-HEIRELRLFHFTSW 1069
Query: 424 PDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKG 483
PDHGVP G+L F+ +V K + +AGP+VVHCSAG GRTG FI ID ++D+ +G
Sbjct: 1070 PDHGVPCYATGLLGFVRQV--KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEG 1127
Query: 484 VDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
V +D+ ++ +R+QR +VQTE QY F++ A+
Sbjct: 1128 V---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159
Score = 105 bits (262), Expect = 1e-22
Identities = 88/316 (27%), Positives = 149/316 (47%), Gaps = 34/316 (10%)
Query: 219 TRINAAEIESRVRELSKLAETTDKVKQGFWEEFETL-------QQQECKLLYSRKEGQRQ 271
T I E S +S+L T+ + +EF+TL + ++C + G
Sbjct: 1168 TAIPVCEFRSLYYNISRLDPQTNSSQ--IKDEFQTLNIVTPRVRPEDCSI------GLLP 1219
Query: 272 ENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQ 331
N +KNR ++LP D L D S+YINA ++ ++ K +++ TQ
Sbjct: 1220 RNHDKNRSMDVLPLDRCLPFLISVDGES--SNYINAALM--------DSHKQPAAFVVTQ 1269
Query: 332 GCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKES 391
L NTV DFWR+VF N +VM E++ + C++YWP++ + YG ++V V
Sbjct: 1270 HPLPNTVADFWRLVFDYNCSSVVM-LNEMDTAQF-CMQYWPEKTS-GCYGPIQVEFVSAD 1326
Query: 392 AAHDYTLRELKLSKVGQ-GNTERTVWQYHFRTWPDH-GVPSDPGGVLDFLEEVHHKQESI 449
D R ++ + + + R V + WP + P +L + + QE
Sbjct: 1327 IDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQY 1386
Query: 450 MD-AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTE 508
G VVHC G GR+GTF I + ++I+++ + IDV ++ +R+ +S MV+T
Sbjct: 1387 DGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNI---IDVFHIVKTLRNNKSNMVETL 1443
Query: 509 AQYRFIYMAVQHYIET 524
QY+F+Y Y+ +
Sbjct: 1444 EQYKFVYEVALEYLSS 1459
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 209 bits (533), Expect = 4e-54
Identities = 125/306 (40%), Positives = 180/306 (58%), Gaps = 22/306 (7%)
Query: 213 KQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQE 272
+ P T +++ A + + + L +T+D GF EE+E+ + + S ++ +
Sbjct: 856 ESPYQTGQLHPAIRVADLLQHINLMKTSDSY--GFKEEYESFFEGQSA---SWDVAKKDQ 910
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
N+ KNRY NI+ +DH+RV+L + ++P SDYINAN I + + YIATQG
Sbjct: 911 NRAKNRYGNIIAYDHSRVILQPVE-DDPSSDYINANYI--------DGYQRPSHYIATQG 961
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
+ TV DFWRM++QE S IVM T VE G+ KC KYWPD+ + YG +V V+
Sbjct: 962 PVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD--TEVYGDFKVTCVEMEP 1019
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
+Y +R L + G N R V Q+HF WPDHGVP G+L F+ V K + A
Sbjct: 1020 LAEYVVRTFTLERRGY-NEIREVKQFHFTGWPDHGVPYHATGLLSFIRRV--KLSNPPSA 1076
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+VVHCSAG GRTG +IVIDI++D+ +GV +D+ ++ +RS+R MVQTE QY
Sbjct: 1077 GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGV---VDIYNCVKALRSRRINMVQTEEQYI 1133
Query: 513 FIYMAV 518
FI+ A+
Sbjct: 1134 FIHDAI 1139
Score = 104 bits (260), Expect = 2e-22
Identities = 82/288 (28%), Positives = 141/288 (48%), Gaps = 36/288 (12%)
Query: 249 EEFETL-------QQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTR--VVLHDGDPNE 299
+EF+TL Q ++C + + N +KNR+ ++LP D ++ DG+
Sbjct: 1176 DEFQTLNSVTPRLQAEDCSIACLPR------NHDKNRFMDMLPPDRCLPFLITIDGES-- 1227
Query: 300 PVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKE 359
S+YINA ++ ++ + ++I TQ L NTV DFWR+V+ IVM E
Sbjct: 1228 --SNYINAALM--------DSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM-LNE 1276
Query: 360 VERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNT-ERTVWQY 418
V+ + C +YWP+E L+ YG ++V + S D R ++ + + V Q+
Sbjct: 1277 VDLSQG-CPQYWPEEGMLR-YGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQF 1334
Query: 419 HFRTWPDH-GVPSDPGGVLDFLEEVHHKQESIMDA-GPVVVHCSAGIGRTGTFIVIDILI 476
+ W H VP L + +V QE + G ++HC G GR+G F I I++
Sbjct: 1335 QYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVV 1394
Query: 477 DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET 524
++++ + V +DV ++ +R+ + MV+ QYRF Y Y+E+
Sbjct: 1395 EMVKRQNV---VDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1439
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 209 bits (532), Expect = 6e-54
Identities = 125/306 (40%), Positives = 181/306 (59%), Gaps = 16/306 (5%)
Query: 213 KQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQE 272
+ P T +++ A + + + L +T+D GF EE+E+ + + S ++ +
Sbjct: 856 ESPYQTGQLHPAIRVADLLQHINLMKTSDSY--GFKEEYESFFEGQSA---SWDVAKKDQ 910
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
N+ KNRY NI+ +DH+RV+L + ++P SDYINAN I + + + YIATQG
Sbjct: 911 NRAKNRYGNIIAYDHSRVILQPVE-DDPSSDYINANYI--DIWLYRDGYQRPSHYIATQG 967
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
+ TV DFWRM++QE S IVM T VE G+ KC KYWPD+ + YG +V V+
Sbjct: 968 PVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD--TEVYGDFKVTCVEMEP 1025
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
+Y +R L + G N R V Q+HF WPDHGVP G+L F+ V K + A
Sbjct: 1026 LAEYVVRTFTLERRGY-NEIREVKQFHFTGWPDHGVPYHATGLLSFIRRV--KLSNPPSA 1082
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+VVHCSAG GRTG +IVIDI++D+ +GV +D+ ++ +RS+R MVQTE QY
Sbjct: 1083 GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGV---VDIYNCVKALRSRRINMVQTEEQYI 1139
Query: 513 FIYMAV 518
FI+ A+
Sbjct: 1140 FIHDAI 1145
Score = 104 bits (260), Expect = 2e-22
Identities = 82/288 (28%), Positives = 141/288 (48%), Gaps = 36/288 (12%)
Query: 249 EEFETL-------QQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTR--VVLHDGDPNE 299
+EF+TL Q ++C + + N +KNR+ ++LP D ++ DG+
Sbjct: 1182 DEFQTLNSVTPRLQAEDCSIACLPR------NHDKNRFMDMLPPDRCLPFLITIDGES-- 1233
Query: 300 PVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKE 359
S+YINA ++ ++ + ++I TQ L NTV DFWR+V+ IVM E
Sbjct: 1234 --SNYINAALM--------DSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM-LNE 1282
Query: 360 VERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNT-ERTVWQY 418
V+ + C +YWP+E L+ YG ++V + S D R ++ + + V Q+
Sbjct: 1283 VDLSQG-CPQYWPEEGMLR-YGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQF 1340
Query: 419 HFRTWPDH-GVPSDPGGVLDFLEEVHHKQESIMDA-GPVVVHCSAGIGRTGTFIVIDILI 476
+ W H VP L + +V QE + G ++HC G GR+G F I I++
Sbjct: 1341 QYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVV 1400
Query: 477 DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET 524
++++ + V +DV ++ +R+ + MV+ QYRF Y Y+E+
Sbjct: 1401 EMVKRQNV---VDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 202 bits (513), Expect = 9e-52
Identities = 119/275 (43%), Positives = 165/275 (60%), Gaps = 24/275 (8%)
Query: 246 GFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLH--DGDPNEPVSD 303
GF EE+E+ + + S K + EN+ KNRY NI+ +DH+RV L +GD N SD
Sbjct: 899 GFKEEYESFFEGQSAPWDSAK---KDENRMKNRYGNIIAYDHSRVRLQTIEGDTN---SD 952
Query: 304 YINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG 363
YIN N I + YIATQG +Q T+ DFWRMV+ EN+ I+M T VE G
Sbjct: 953 YINGNYI--------DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVG 1004
Query: 364 KSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTW 423
+ KC KYWPD+ + Y ++V ++ +Y +R + K G + R + Q+HF W
Sbjct: 1005 RVKCCKYWPDDTEI--YKDIKVTLIETELLAEYVIRTFAVEKRGV-HEIREIRQFHFTGW 1061
Query: 424 PDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKG 483
PDHGVP G+L F+ +V K +S AGP+VVHCSAG GRTG FIVIDI++D+ +G
Sbjct: 1062 PDHGVPYHATGLLGFVRQV--KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREG 1119
Query: 484 VDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
V +D+ ++ +RS+R MVQTE QY FI+ A+
Sbjct: 1120 V---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1151
Score = 101 bits (252), Expect = 2e-21
Identities = 88/318 (27%), Positives = 146/318 (45%), Gaps = 38/318 (11%)
Query: 219 TRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQ-------QECKLLYSRKEGQRQ 271
T + A+++ S +++KL T+ + EEF TL ++C + +
Sbjct: 1160 TSVPASQVRSLYYDMNKLDPQTNSSQ--IKEEFRTLNMVTPTLRVEDCSIALLPR----- 1212
Query: 272 ENKNKNRYKNILPFDHTR--VVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIA 329
N KNR +ILP D ++ DG+ S+YINA ++ ++ K ++I
Sbjct: 1213 -NHEKNRCMDILPPDRCLPFLITIDGES----SNYINAALM--------DSYKQPSAFIV 1259
Query: 330 TQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVK 389
TQ L NTV DFWR+V + +VM +V+ + C +YWP E + +G ++V V
Sbjct: 1260 TQHPLPNTVKDFWRLVLDYHCTSVVM-LNDVDPAQ-LCPQYWP-ENGVHRHGPIQVEFVS 1316
Query: 390 ESAAHDYTLRELKLSKVGQ-GNTERTVWQYHFRTWPDH-GVPSDPGGVLDFLEEVHHKQE 447
D R ++ + + R V Q+ F WP + P L + +V QE
Sbjct: 1317 ADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQE 1376
Query: 448 SIMDA-GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQ 506
G VVHC G GR+GTF I I+ +++R + +DV ++ +R+ + MV
Sbjct: 1377 EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT---VDVFHAVKTLRNNKPNMVD 1433
Query: 507 TEAQYRFIYMAVQHYIET 524
QY+F Y Y+ +
Sbjct: 1434 LLDQYKFCYEVALEYLNS 1451
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 202 bits (513), Expect = 9e-52
Identities = 119/275 (43%), Positives = 165/275 (60%), Gaps = 24/275 (8%)
Query: 246 GFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLH--DGDPNEPVSD 303
GF EE+E+ + + S K + EN+ KNRY NI+ +DH+RV L +GD N SD
Sbjct: 912 GFKEEYESFFEGQSAPWDSAK---KDENRMKNRYGNIIAYDHSRVRLQTIEGDTN---SD 965
Query: 304 YINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG 363
YIN N I + YIATQG +Q T+ DFWRMV+ EN+ I+M T VE G
Sbjct: 966 YINGNYI--------DGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVG 1017
Query: 364 KSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTW 423
+ KC KYWPD+ + Y ++V ++ +Y +R + K G + R + Q+HF W
Sbjct: 1018 RVKCCKYWPDDTEI--YKDIKVTLIETELLAEYVIRTFAVEKRGV-HEIREIRQFHFTGW 1074
Query: 424 PDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKG 483
PDHGVP G+L F+ +V K +S AGP+VVHCSAG GRTG FIVIDI++D+ +G
Sbjct: 1075 PDHGVPYHATGLLGFVRQV--KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREG 1132
Query: 484 VDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
V +D+ ++ +RS+R MVQTE QY FI+ A+
Sbjct: 1133 V---VDIYNCVRELRSRRVNMVQTEEQYVFIHDAI 1164
Score = 101 bits (252), Expect = 2e-21
Identities = 88/318 (27%), Positives = 146/318 (45%), Gaps = 38/318 (11%)
Query: 219 TRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQ-------QECKLLYSRKEGQRQ 271
T + A+++ S +++KL T+ + EEF TL ++C + +
Sbjct: 1173 TSVPASQVRSLYYDMNKLDPQTNSSQ--IKEEFRTLNMVTPTLRVEDCSIALLPR----- 1225
Query: 272 ENKNKNRYKNILPFDHTR--VVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIA 329
N KNR +ILP D ++ DG+ S+YINA ++ ++ K ++I
Sbjct: 1226 -NHEKNRCMDILPPDRCLPFLITIDGES----SNYINAALM--------DSYKQPSAFIV 1272
Query: 330 TQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVK 389
TQ L NTV DFWR+V + +VM +V+ + C +YWP E + +G ++V V
Sbjct: 1273 TQHPLPNTVKDFWRLVLDYHCTSVVM-LNDVDPAQ-LCPQYWP-ENGVHRHGPIQVEFVS 1329
Query: 390 ESAAHDYTLRELKLSKVGQ-GNTERTVWQYHFRTWPDH-GVPSDPGGVLDFLEEVHHKQE 447
D R ++ + + R V Q+ F WP + P L + +V QE
Sbjct: 1330 ADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQE 1389
Query: 448 SIMDA-GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQ 506
G VVHC G GR+GTF I I+ +++R + +DV ++ +R+ + MV
Sbjct: 1390 EYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRT---VDVFHAVKTLRNNKPNMVD 1446
Query: 507 TEAQYRFIYMAVQHYIET 524
QY+F Y Y+ +
Sbjct: 1447 LLDQYKFCYEVALEYLNS 1464
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 199 bits (507), Expect = 5e-51
Identities = 124/285 (43%), Positives = 168/285 (58%), Gaps = 20/285 (7%)
Query: 239 TTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPN 298
+ D KQ F EEF +L + + ++EN+ KNRY NILP DH+RV+L D
Sbjct: 128 SADDCKQ-FREEFNSLPSGHIQGTFEL--ANKEENREKNRYPNILPNDHSRVILSQLD-G 183
Query: 299 EPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTK 358
P SDYINA+ I + K K +IA QG Q TVNDFWRMV+++ S IVM T
Sbjct: 184 IPCSDYINASYI--------DGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTN 235
Query: 359 EVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLS-KVGQG-NTERTVW 416
ER + KC +YWPD+ YG +RV DYT+R+ + ++ G R V
Sbjct: 236 LKERKEEKCHQYWPDQ-GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVS 294
Query: 417 QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILI 476
Q HF +WPD GVP P G+L FL++V K + + AGP+VVHCSAG+GRTGTFIVID ++
Sbjct: 295 QLHFTSWPDFGVPFTPIGMLKFLKKV--KTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMM 352
Query: 477 DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY 521
++ + +DV + + +R+QR MVQT+ QY FIY A+ Y
Sbjct: 353 AMMH---AEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 394
Score = 165 bits (417), Expect = 1e-40
Identities = 102/309 (33%), Positives = 165/309 (53%), Gaps = 21/309 (6%)
Query: 219 TRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNR 278
T ++ + +E ++ + DK+ G EEF L + + + G N K R
Sbjct: 400 TELDVSSLEKHLQTMHGTTTHFDKI--GLEEEFRKLTNVRI-MKENMRTGNLPANMKKAR 456
Query: 279 YKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTV 338
I+P+D RV+L E +DYINA+ I + + K +IATQG L +TV
Sbjct: 457 VIQIIPYDFNRVILSMKRGQE-YTDYINASFI--------DGYRQKDYFIATQGPLAHTV 507
Query: 339 NDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTL 398
DFWRM+++ S IVM T+ ER + KC +YWP E ++ +G + + ++ + ++
Sbjct: 508 EDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSV-THGEITIEIKNDTLSEAISI 566
Query: 399 RE----LKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGP 454
R+ L + Q R V Q+HF WP+ G+P++ G++D + V KQ+ P
Sbjct: 567 RDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-QKQQQQTGNHP 625
Query: 455 VVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFI 514
+ VHCSAG GRTGTFI + +++ ++ +G+ +DV + ++ +R QR MVQT QY F
Sbjct: 626 ITVHCSAGAGRTGTFIALSNILERVKAEGL---LDVFQAVKSLRLQRPHMVQTLEQYEFC 682
Query: 515 YMAVQHYIE 523
Y VQ +I+
Sbjct: 683 YKVVQDFID 691
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform
2 [Homo sapiens]
Length = 642
Score = 199 bits (507), Expect = 5e-51
Identities = 124/285 (43%), Positives = 168/285 (58%), Gaps = 20/285 (7%)
Query: 239 TTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPN 298
+ D KQ F EEF +L + + ++EN+ KNRY NILP DH+RV+L D
Sbjct: 70 SADDCKQ-FREEFNSLPSGHIQGTFEL--ANKEENREKNRYPNILPNDHSRVILSQLD-G 125
Query: 299 EPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTK 358
P SDYINA+ I + K K +IA QG Q TVNDFWRMV+++ S IVM T
Sbjct: 126 IPCSDYINASYI--------DGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTN 177
Query: 359 EVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLS-KVGQG-NTERTVW 416
ER + KC +YWPD+ YG +RV DYT+R+ + ++ G R V
Sbjct: 178 LKERKEEKCHQYWPDQ-GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVS 236
Query: 417 QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILI 476
Q HF +WPD GVP P G+L FL++V K + + AGP+VVHCSAG+GRTGTFIVID ++
Sbjct: 237 QLHFTSWPDFGVPFTPIGMLKFLKKV--KTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMM 294
Query: 477 DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY 521
++ + +DV + + +R+QR MVQT+ QY FIY A+ Y
Sbjct: 295 AMMH---AEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 336
Score = 165 bits (417), Expect = 1e-40
Identities = 102/309 (33%), Positives = 165/309 (53%), Gaps = 21/309 (6%)
Query: 219 TRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNR 278
T ++ + +E ++ + DK+ G EEF L + + + G N K R
Sbjct: 342 TELDVSSLEKHLQTMHGTTTHFDKI--GLEEEFRKLTNVRI-MKENMRTGNLPANMKKAR 398
Query: 279 YKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTV 338
I+P+D RV+L E +DYINA+ I + + K +IATQG L +TV
Sbjct: 399 VIQIIPYDFNRVILSMKRGQE-YTDYINASFI--------DGYRQKDYFIATQGPLAHTV 449
Query: 339 NDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTL 398
DFWRM+++ S IVM T+ ER + KC +YWP E ++ +G + + ++ + ++
Sbjct: 450 EDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSV-THGEITIEIKNDTLSEAISI 508
Query: 399 RE----LKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGP 454
R+ L + Q R V Q+HF WP+ G+P++ G++D + V KQ+ P
Sbjct: 509 RDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-QKQQQQTGNHP 567
Query: 455 VVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFI 514
+ VHCSAG GRTGTFI + +++ ++ +G+ +DV + ++ +R QR MVQT QY F
Sbjct: 568 ITVHCSAGAGRTGTFIALSNILERVKAEGL---LDVFQAVKSLRLQRPHMVQTLEQYEFC 624
Query: 515 YMAVQHYIE 523
Y VQ +I+
Sbjct: 625 YKVVQDFID 633
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 198 bits (504), Expect = 1e-50
Identities = 121/320 (37%), Positives = 184/320 (57%), Gaps = 30/320 (9%)
Query: 236 LAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHD- 294
+ E + GF E+FE +Q+ + + + ENK+KNRY NIL +DH+RV L
Sbjct: 837 IGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPL 896
Query: 295 GDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIV 354
+ SDYINAN + + K+YIATQG L++T DFWRM++++N+ +IV
Sbjct: 897 PGKDSKHSDYINANYV--------DGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIV 948
Query: 355 MTTKEVERGKSKCVKYWPDEYALKEYG--VMRVRNVKESAAHD---YTLRELKLSKVGQG 409
M T VE+G+ KC +YWP E + +EYG ++ +++ K A + +++R K+ K +G
Sbjct: 949 MITNLVEKGRRKCDQYWPTENS-EEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKG 1007
Query: 410 N-----TERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIG 464
N ER V QYH+ WPD GVP VL F+ + + GPV+VHCSAG+G
Sbjct: 1008 NPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVR--RSSAARMPETGPVLVHCSAGVG 1065
Query: 465 RTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET 524
RTGT+IVID ++ I++K ++V ++ +R+QR+ +VQTE QY FI+ A+ I
Sbjct: 1066 RTGTYIVIDSMLQQIKDKST---VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILG 1122
Query: 525 LQRRIEEEQKSKRKGHEYTN 544
+E + S + H Y N
Sbjct: 1123 -----KETEVSSNQLHSYVN 1137
Score = 82.0 bits (201), Expect = 1e-15
Identities = 67/266 (25%), Positives = 113/266 (42%), Gaps = 33/266 (12%)
Query: 269 QRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYI 328
Q++ NK KNR +++P + RV L P +DYINA+ IM + + +I
Sbjct: 1171 QKECNKEKNRNSSVVPSERARVGLAPL-PGMKGTDYINASYIMGYYRSN--------EFI 1221
Query: 329 ATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDE----------YALK 378
TQ L +T DFWRM++ N+++IVM + + V YWP L
Sbjct: 1222 ITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSREESMNCEAFTVTLI 1280
Query: 379 EYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDF 438
+ + N ++ HD+ L + Q + V + WP+ P +
Sbjct: 1281 SKDRLCLSNEEQIIIHDFIL------EATQDDYVLEVRHFQCPKWPNPDAPI--SSTFEL 1332
Query: 439 LEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVR 498
+ + K+E++ GP +VH G G + L + + +DV + +M+
Sbjct: 1333 INVI--KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENA---VDVFQVAKMIN 1387
Query: 499 SQRSGMVQTEAQYRFIYMAVQHYIET 524
R G+ QY+FIY A+ + T
Sbjct: 1388 LMRPGVFTDIEQYQFIYKAMLSLVST 1413
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 196 bits (498), Expect = 5e-50
Identities = 108/250 (43%), Positives = 152/250 (60%), Gaps = 14/250 (5%)
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
NK KNR NI+P++ TRV L E SDYINA+ I + + +K+YIATQG
Sbjct: 1259 NKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFI--------DGYRQQKAYIATQG 1309
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
L T DFWRM+++ NS ++VM TK E G+ KC +YWP E + + Y V + E
Sbjct: 1310 PLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYN 1368
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
Y LRE K++ G + RTV Q+ F WP+ GVP G +DF+ +VH +E
Sbjct: 1369 MPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD 1427
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+ VHCSAG+GRTG FI + I+++ +R +GV +D+ +T++M+R+QR MVQTE QY+
Sbjct: 1428 GPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQ 1484
Query: 513 FIYMAVQHYI 522
F Y A Y+
Sbjct: 1485 FSYRAALEYL 1494
Score = 185 bits (469), Expect = 1e-46
Identities = 110/288 (38%), Positives = 168/288 (58%), Gaps = 23/288 (7%)
Query: 235 KLAETTDKVKQG----FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRV 290
+LA+ +++K F +E+E++ + ++ + + NK KNRY N++ +DH+RV
Sbjct: 931 ELADHIERLKANDNLKFSQEYESIDPGQ---QFTWEHSNLEVNKPKNRYANVIAYDHSRV 987
Query: 291 VLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENS 350
+L P SDY+NAN I + + + +YIATQG L T DFWRM++++ S
Sbjct: 988 LL-SAIEGIPGSDYVNANYI--------DGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1038
Query: 351 RVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGN 410
+VM TK ER + KC +YWP + +G+++V + Y +R L K G +
Sbjct: 1039 ATVVMMTKLEERSRVKCDQYWPSR-GTETHGLVQVTLLDTVELATYCVRTFALYKNG-SS 1096
Query: 411 TERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFI 470
+R V Q+ F WPDHGVP P L FL V K + DAGP+VVHCSAG+GRTG FI
Sbjct: 1097 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV--KTCNPPDAGPMVVHCSAGVGRTGCFI 1154
Query: 471 VIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
VID +++ I+ + +D+ + ++R+QR+ MVQTE QY FI+ A+
Sbjct: 1155 VIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1199
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 196 bits (498), Expect = 5e-50
Identities = 108/250 (43%), Positives = 152/250 (60%), Gaps = 14/250 (5%)
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
NK KNR NI+P++ TRV L E SDYINA+ I + + +K+YIATQG
Sbjct: 1669 NKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFI--------DGYRQQKAYIATQG 1719
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
L T DFWRM+++ NS ++VM TK E G+ KC +YWP E + + Y V + E
Sbjct: 1720 PLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYN 1778
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
Y LRE K++ G + RTV Q+ F WP+ GVP G +DF+ +VH +E
Sbjct: 1779 MPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD 1837
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+ VHCSAG+GRTG FI + I+++ +R +GV +D+ +T++M+R+QR MVQTE QY+
Sbjct: 1838 GPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQ 1894
Query: 513 FIYMAVQHYI 522
F Y A Y+
Sbjct: 1895 FSYRAALEYL 1904
Score = 185 bits (469), Expect = 1e-46
Identities = 110/288 (38%), Positives = 168/288 (58%), Gaps = 23/288 (7%)
Query: 235 KLAETTDKVKQG----FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRV 290
+LA+ +++K F +E+E++ + ++ + + NK KNRY N++ +DH+RV
Sbjct: 1341 ELADHIERLKANDNLKFSQEYESIDPGQ---QFTWEHSNLEVNKPKNRYANVIAYDHSRV 1397
Query: 291 VLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENS 350
+L P SDY+NAN I + + + +YIATQG L T DFWRM++++ S
Sbjct: 1398 LL-SAIEGIPGSDYVNANYI--------DGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1448
Query: 351 RVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGN 410
+VM TK ER + KC +YWP + +G+++V + Y +R L K G +
Sbjct: 1449 ATVVMMTKLEERSRVKCDQYWPSR-GTETHGLVQVTLLDTVELATYCVRTFALYKNG-SS 1506
Query: 411 TERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFI 470
+R V Q+ F WPDHGVP P L FL V K + DAGP+VVHCSAG+GRTG FI
Sbjct: 1507 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV--KTCNPPDAGPMVVHCSAGVGRTGCFI 1564
Query: 471 VIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
VID +++ I+ + +D+ + ++R+QR+ MVQTE QY FI+ A+
Sbjct: 1565 VIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1609
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 196 bits (498), Expect = 5e-50
Identities = 108/250 (43%), Positives = 152/250 (60%), Gaps = 14/250 (5%)
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
NK KNR NI+P++ TRV L E SDYINA+ I + + +K+YIATQG
Sbjct: 1656 NKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFI--------DGYRQQKAYIATQG 1706
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
L T DFWRM+++ NS ++VM TK E G+ KC +YWP E + + Y V + E
Sbjct: 1707 PLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYN 1765
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
Y LRE K++ G + RTV Q+ F WP+ GVP G +DF+ +VH +E
Sbjct: 1766 MPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD 1824
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+ VHCSAG+GRTG FI + I+++ +R +GV +D+ +T++M+R+QR MVQTE QY+
Sbjct: 1825 GPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQ 1881
Query: 513 FIYMAVQHYI 522
F Y A Y+
Sbjct: 1882 FSYRAALEYL 1891
Score = 185 bits (469), Expect = 1e-46
Identities = 110/288 (38%), Positives = 168/288 (58%), Gaps = 23/288 (7%)
Query: 235 KLAETTDKVKQG----FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRV 290
+LA+ +++K F +E+E++ + ++ + + NK KNRY N++ +DH+RV
Sbjct: 1328 ELADHIERLKANDNLKFSQEYESIDPGQ---QFTWEHSNLEVNKPKNRYANVIAYDHSRV 1384
Query: 291 VLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENS 350
+L P SDY+NAN I + + + +YIATQG L T DFWRM++++ S
Sbjct: 1385 LL-SAIEGIPGSDYVNANYI--------DGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1435
Query: 351 RVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGN 410
+VM TK ER + KC +YWP + +G+++V + Y +R L K G +
Sbjct: 1436 ATVVMMTKLEERSRVKCDQYWPSR-GTETHGLVQVTLLDTVELATYCVRTFALYKNG-SS 1493
Query: 411 TERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFI 470
+R V Q+ F WPDHGVP P L FL V K + DAGP+VVHCSAG+GRTG FI
Sbjct: 1494 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV--KTCNPPDAGPMVVHCSAGVGRTGCFI 1551
Query: 471 VIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
VID +++ I+ + +D+ + ++R+QR+ MVQTE QY FI+ A+
Sbjct: 1552 VIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1596
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 196 bits (498), Expect = 5e-50
Identities = 108/250 (43%), Positives = 152/250 (60%), Gaps = 14/250 (5%)
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
NK KNR NI+P++ TRV L E SDYINA+ I + + +K+YIATQG
Sbjct: 1660 NKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFI--------DGYRQQKAYIATQG 1710
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
L T DFWRM+++ NS ++VM TK E G+ KC +YWP E + + Y V + E
Sbjct: 1711 PLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYN 1769
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
Y LRE K++ G + RTV Q+ F WP+ GVP G +DF+ +VH +E
Sbjct: 1770 MPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD 1828
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+ VHCSAG+GRTG FI + I+++ +R +GV +D+ +T++M+R+QR MVQTE QY+
Sbjct: 1829 GPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQ 1885
Query: 513 FIYMAVQHYI 522
F Y A Y+
Sbjct: 1886 FSYRAALEYL 1895
Score = 185 bits (469), Expect = 1e-46
Identities = 110/288 (38%), Positives = 168/288 (58%), Gaps = 23/288 (7%)
Query: 235 KLAETTDKVKQG----FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRV 290
+LA+ +++K F +E+E++ + ++ + + NK KNRY N++ +DH+RV
Sbjct: 1332 ELADHIERLKANDNLKFSQEYESIDPGQ---QFTWEHSNLEVNKPKNRYANVIAYDHSRV 1388
Query: 291 VLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENS 350
+L P SDY+NAN I + + + +YIATQG L T DFWRM++++ S
Sbjct: 1389 LL-SAIEGIPGSDYVNANYI--------DGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1439
Query: 351 RVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGN 410
+VM TK ER + KC +YWP + +G+++V + Y +R L K G +
Sbjct: 1440 ATVVMMTKLEERSRVKCDQYWPSR-GTETHGLVQVTLLDTVELATYCVRTFALYKNG-SS 1497
Query: 411 TERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFI 470
+R V Q+ F WPDHGVP P L FL V K + DAGP+VVHCSAG+GRTG FI
Sbjct: 1498 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV--KTCNPPDAGPMVVHCSAGVGRTGCFI 1555
Query: 471 VIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
VID +++ I+ + +D+ + ++R+QR+ MVQTE QY FI+ A+
Sbjct: 1556 VIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1600
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 196 bits (498), Expect = 5e-50
Identities = 108/250 (43%), Positives = 152/250 (60%), Gaps = 14/250 (5%)
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
NK KNR NI+P++ TRV L E SDYINA+ I + + +K+YIATQG
Sbjct: 1258 NKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFI--------DGYRQQKAYIATQG 1308
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
L T DFWRM+++ NS ++VM TK E G+ KC +YWP E + + Y V + E
Sbjct: 1309 PLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYN 1367
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
Y LRE K++ G + RTV Q+ F WP+ GVP G +DF+ +VH +E
Sbjct: 1368 MPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD 1426
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+ VHCSAG+GRTG FI + I+++ +R +GV +D+ +T++M+R+QR MVQTE QY+
Sbjct: 1427 GPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDQYQ 1483
Query: 513 FIYMAVQHYI 522
F Y A Y+
Sbjct: 1484 FSYRAALEYL 1493
Score = 185 bits (469), Expect = 1e-46
Identities = 110/288 (38%), Positives = 168/288 (58%), Gaps = 23/288 (7%)
Query: 235 KLAETTDKVKQG----FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRV 290
+LA+ +++K F +E+E++ + ++ + + NK KNRY N++ +DH+RV
Sbjct: 930 ELADHIERLKANDNLKFSQEYESIDPGQ---QFTWEHSNLEVNKPKNRYANVIAYDHSRV 986
Query: 291 VLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENS 350
+L P SDY+NAN I + + + +YIATQG L T DFWRM++++ S
Sbjct: 987 LL-SAIEGIPGSDYVNANYI--------DGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1037
Query: 351 RVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGN 410
+VM TK ER + KC +YWP + +G+++V + Y +R L K G +
Sbjct: 1038 ATVVMMTKLEERSRVKCDQYWPSR-GTETHGLVQVTLLDTVELATYCVRTFALYKNG-SS 1095
Query: 411 TERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFI 470
+R V Q+ F WPDHGVP P L FL V K + DAGP+VVHCSAG+GRTG FI
Sbjct: 1096 EKREVRQFQFTAWPDHGVPEHPTPFLAFLRRV--KTCNPPDAGPMVVHCSAGVGRTGCFI 1153
Query: 471 VIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
VID +++ I+ + +D+ + ++R+QR+ MVQTE QY FI+ A+
Sbjct: 1154 VIDAMLERIKHEKT---VDIYGHVTLMRAQRNYMVQTEDQYIFIHDAL 1198
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 196 bits (497), Expect = 7e-50
Identities = 107/250 (42%), Positives = 152/250 (60%), Gaps = 14/250 (5%)
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
NK KNR NI+P++ TRV L E SDYINA+ I + + +K+YIATQG
Sbjct: 1262 NKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFI--------DGYRQQKAYIATQG 1312
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
L T DFWRM+++ NS ++VM TK E G+ KC +YWP E + + Y V + E
Sbjct: 1313 PLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYN 1371
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
Y LRE K++ G + RTV Q+ F WP+ GVP G +DF+ +VH +E
Sbjct: 1372 MPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD 1430
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+ VHCSAG+GRTG FI + I+++ +R +GV +D+ +T++M+R+QR MVQTE +Y+
Sbjct: 1431 GPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQ 1487
Query: 513 FIYMAVQHYI 522
F Y A Y+
Sbjct: 1488 FCYQAALEYL 1497
Score = 187 bits (476), Expect = 2e-47
Identities = 125/329 (37%), Positives = 182/329 (55%), Gaps = 30/329 (9%)
Query: 192 DLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEF 251
DL H+ K+P VE Q L+ I A++ L + D +K +E+
Sbjct: 902 DLAPHHPKDP-VEMRRINFQTPGMLSHPPIPIADMAEHTERL----KANDSLKLS--QEY 954
Query: 252 ETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPV--SDYINANI 309
E++ + ++ + + NK KNRY N++ +DH+RV+L P E + SDYINAN
Sbjct: 955 ESIDPGQ---QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ---PIEGIMGSDYINANY 1008
Query: 310 IMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVK 369
+ +C N+ YIATQG L T DFWRMV+++ S IVM T+ E+ + KC +
Sbjct: 1009 VDGY---RCQNA-----YIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQ 1060
Query: 370 YWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVP 429
YWP+ + YG ++V + + +R L K G + +R V Q+ F WPDHGVP
Sbjct: 1061 YWPNR-GTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVP 1118
Query: 430 SDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDID 489
P L FL V K + DAGP+VVHCSAG+GRTG FIVID +++ I+ + +D
Sbjct: 1119 EYPTPFLAFLRRV--KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT---VD 1173
Query: 490 VPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
V + ++RSQR+ MVQTE QY FI+ A+
Sbjct: 1174 VYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1202
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 196 bits (497), Expect = 7e-50
Identities = 107/250 (42%), Positives = 152/250 (60%), Gaps = 14/250 (5%)
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
NK KNR NI+P++ TRV L E SDYINA+ I + + +K+YIATQG
Sbjct: 1667 NKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFI--------DGYRQQKAYIATQG 1717
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
L T DFWRM+++ NS ++VM TK E G+ KC +YWP E + + Y V + E
Sbjct: 1718 PLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYN 1776
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
Y LRE K++ G + RTV Q+ F WP+ GVP G +DF+ +VH +E
Sbjct: 1777 MPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD 1835
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+ VHCSAG+GRTG FI + I+++ +R +GV +D+ +T++M+R+QR MVQTE +Y+
Sbjct: 1836 GPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQ 1892
Query: 513 FIYMAVQHYI 522
F Y A Y+
Sbjct: 1893 FCYQAALEYL 1902
Score = 187 bits (476), Expect = 2e-47
Identities = 125/329 (37%), Positives = 182/329 (55%), Gaps = 30/329 (9%)
Query: 192 DLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEF 251
DL H+ K+P VE Q L+ I A++ L + D +K +E+
Sbjct: 1307 DLAPHHPKDP-VEMRRINFQTPGMLSHPPIPIADMAEHTERL----KANDSLKLS--QEY 1359
Query: 252 ETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPV--SDYINANI 309
E++ + ++ + + NK KNRY N++ +DH+RV+L P E + SDYINAN
Sbjct: 1360 ESIDPGQ---QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ---PIEGIMGSDYINANY 1413
Query: 310 IMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVK 369
+ +C N+ YIATQG L T DFWRMV+++ S IVM T+ E+ + KC +
Sbjct: 1414 VDGY---RCQNA-----YIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQ 1465
Query: 370 YWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVP 429
YWP+ + YG ++V + + +R L K G + +R V Q+ F WPDHGVP
Sbjct: 1466 YWPNR-GTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVP 1523
Query: 430 SDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDID 489
P L FL V K + DAGP+VVHCSAG+GRTG FIVID +++ I+ + +D
Sbjct: 1524 EYPTPFLAFLRRV--KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT---VD 1578
Query: 490 VPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
V + ++RSQR+ MVQTE QY FI+ A+
Sbjct: 1579 VYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1607
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 196 bits (497), Expect = 7e-50
Identities = 107/250 (42%), Positives = 152/250 (60%), Gaps = 14/250 (5%)
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
NK KNR NI+P++ TRV L E SDYINA+ I + + +K+YIATQG
Sbjct: 1258 NKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFI--------DGYRQQKAYIATQG 1308
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
L T DFWRM+++ NS ++VM TK E G+ KC +YWP E + + Y V + E
Sbjct: 1309 PLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYN 1367
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
Y LRE K++ G + RTV Q+ F WP+ GVP G +DF+ +VH +E
Sbjct: 1368 MPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD 1426
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+ VHCSAG+GRTG FI + I+++ +R +GV +D+ +T++M+R+QR MVQTE +Y+
Sbjct: 1427 GPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQ 1483
Query: 513 FIYMAVQHYI 522
F Y A Y+
Sbjct: 1484 FCYQAALEYL 1493
Score = 187 bits (476), Expect = 2e-47
Identities = 125/329 (37%), Positives = 182/329 (55%), Gaps = 30/329 (9%)
Query: 192 DLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEF 251
DL H+ K+P VE Q L+ I A++ L + D +K +E+
Sbjct: 898 DLAPHHPKDP-VEMRRINFQTPGMLSHPPIPIADMAEHTERL----KANDSLKLS--QEY 950
Query: 252 ETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPV--SDYINANI 309
E++ + ++ + + NK KNRY N++ +DH+RV+L P E + SDYINAN
Sbjct: 951 ESIDPGQ---QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ---PIEGIMGSDYINANY 1004
Query: 310 IMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVK 369
+ +C N+ YIATQG L T DFWRMV+++ S IVM T+ E+ + KC +
Sbjct: 1005 VDGY---RCQNA-----YIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQ 1056
Query: 370 YWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVP 429
YWP+ + YG ++V + + +R L K G + +R V Q+ F WPDHGVP
Sbjct: 1057 YWPNR-GTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQFTAWPDHGVP 1114
Query: 430 SDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDID 489
P L FL V K + DAGP+VVHCSAG+GRTG FIVID +++ I+ + +D
Sbjct: 1115 EYPTPFLAFLRRV--KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKT---VD 1169
Query: 490 VPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
V + ++RSQR+ MVQTE QY FI+ A+
Sbjct: 1170 VYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1198
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 196 bits (497), Expect = 7e-50
Identities = 107/250 (42%), Positives = 152/250 (60%), Gaps = 14/250 (5%)
Query: 273 NKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQG 332
NK KNR NI+P++ TRV L E SDYINA+ I + + +K+YIATQG
Sbjct: 1705 NKFKNRLVNIMPYESTRVCLQPIRGVEG-SDYINASFI--------DGYRQQKAYIATQG 1755
Query: 333 CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESA 392
L T DFWRM+++ NS ++VM TK E G+ KC +YWP E + + Y V + E
Sbjct: 1756 PLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSAR-YQYFVVDPMAEYN 1814
Query: 393 AHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDA 452
Y LRE K++ G + RTV Q+ F WP+ GVP G +DF+ +VH +E
Sbjct: 1815 MPQYILREFKVTDARDGQS-RTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQD 1873
Query: 453 GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR 512
GP+ VHCSAG+GRTG FI + I+++ +R +GV +D+ +T++M+R+QR MVQTE +Y+
Sbjct: 1874 GPISVHCSAGVGRTGVFITLSIVLERMRYEGV---VDIFQTVKMLRTQRPAMVQTEDEYQ 1930
Query: 513 FIYMAVQHYI 522
F Y A Y+
Sbjct: 1931 FCYQAALEYL 1940
Score = 187 bits (475), Expect = 2e-47
Identities = 127/339 (37%), Positives = 188/339 (55%), Gaps = 34/339 (10%)
Query: 192 DLVEHYKKNPMVETLGTVLQ-----LKQPLNTTRINAAEIESRVR-ELSKLAETTDKVKQ 245
DL H+ K+P VE Q L+ PL + + S ++ +AE T+++K
Sbjct: 1329 DLAPHHPKDP-VEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAEHTERLKA 1387
Query: 246 G----FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPV 301
+E+E++ + ++ + + NK KNRY N++ +DH+RV+L P E +
Sbjct: 1388 NDSLKLSQEYESIDPGQ---QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQ---PIEGI 1441
Query: 302 --SDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKE 359
SDYINAN + +C N+ YIATQG L T DFWRMV+++ S IVM T+
Sbjct: 1442 MGSDYINANYVDGY---RCQNA-----YIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1493
Query: 360 VERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYH 419
E+ + KC +YWP+ + YG ++V + + +R L K G + +R V Q+
Sbjct: 1494 EEKSRIKCDQYWPNR-GTETYGFIQVTLLDTIELATFCVRTFSLHKNG-SSEKREVRQFQ 1551
Query: 420 FRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDII 479
F WPDHGVP P L FL V K + DAGP+VVHCSAG+GRTG FIVID +++ I
Sbjct: 1552 FTAWPDHGVPEYPTPFLAFLRRV--KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1609
Query: 480 REKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
+ + +DV + ++RSQR+ MVQTE QY FI+ A+
Sbjct: 1610 KPEKT---VDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1645
>gi|157952215 protein tyrosine phosphatase, receptor type, B isoform a
[Homo sapiens]
Length = 2215
Score = 192 bits (487), Expect = 1e-48
Identities = 104/261 (39%), Positives = 152/261 (58%), Gaps = 12/261 (4%)
Query: 272 ENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQ 331
EN+ KNRY NILP+D TRV L + D ++P SDYINA+ I NN + + YI TQ
Sbjct: 1944 ENRGKNRYNNILPYDATRVKLSNVD-DDPCSDYINASYIPG------NNFR--REYIVTQ 1994
Query: 332 GCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKES 391
G L T +DFW+MV+++N IVM T+ VE+G+ KC YWP + YG + ++ + ES
Sbjct: 1995 GPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSES 2054
Query: 392 AAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMD 451
++T+RE K+ Q + R + +H+ WPDHGVP ++ F+ V
Sbjct: 2055 VLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPG 2114
Query: 452 AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQY 511
AGP VVHCSAG+GRTGTFI +D ++ + K +D+ + +R R MVQTE QY
Sbjct: 2115 AGPTVVHCSAGVGRTGTFIALDRILQQLDSKD---SVDIYGAVHDLRLHRVHMVQTECQY 2171
Query: 512 RFIYMAVQHYIETLQRRIEEE 532
+++ V+ + + R E+E
Sbjct: 2172 VYLHQCVRDVLRARKLRSEQE 2192
>gi|157952213 protein tyrosine phosphatase, receptor type, B isoform b
precursor [Homo sapiens]
Length = 1997
Score = 192 bits (487), Expect = 1e-48
Identities = 104/261 (39%), Positives = 152/261 (58%), Gaps = 12/261 (4%)
Query: 272 ENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQ 331
EN+ KNRY NILP+D TRV L + D ++P SDYINA+ I NN + + YI TQ
Sbjct: 1726 ENRGKNRYNNILPYDATRVKLSNVD-DDPCSDYINASYIPG------NNFR--REYIVTQ 1776
Query: 332 GCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKES 391
G L T +DFW+MV+++N IVM T+ VE+G+ KC YWP + YG + ++ + ES
Sbjct: 1777 GPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDLILQMLSES 1836
Query: 392 AAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMD 451
++T+RE K+ Q + R + +H+ WPDHGVP ++ F+ V
Sbjct: 1837 VLPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTVRDYINRSPG 1896
Query: 452 AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQY 511
AGP VVHCSAG+GRTGTFI +D ++ + K +D+ + +R R MVQTE QY
Sbjct: 1897 AGPTVVHCSAGVGRTGTFIALDRILQQLDSKD---SVDIYGAVHDLRLHRVHMVQTECQY 1953
Query: 512 RFIYMAVQHYIETLQRRIEEE 532
+++ V+ + + R E+E
Sbjct: 1954 VYLHQCVRDVLRARKLRSEQE 1974
>gi|4506289 protein tyrosine phosphatase, non-receptor type 1 [Homo
sapiens]
Length = 435
Score = 189 bits (480), Expect = 6e-48
Identities = 106/300 (35%), Positives = 162/300 (54%), Gaps = 31/300 (10%)
Query: 272 ENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQ 331
+NKN+NRY+++ PFDH+R+ LH D +DYINA++I E + ++SYI TQ
Sbjct: 39 KNKNRNRYRDVSPFDHSRIKLHQED-----NDYINASLIKME--------EAQRSYILTQ 85
Query: 332 GCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWP---DEYALKEYGVMRVRNV 388
G L NT FW MV+++ SR +VM + +E+G KC +YWP ++ + E +++ +
Sbjct: 86 GPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLI 145
Query: 389 KESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQES 448
E YT+R+L+L + T R + +H+ TWPD GVP P L+FL +V
Sbjct: 146 SEDIKSYYTVRQLELENLTTQET-REILHFHYTTWPDFGVPESPASFLNFLFKVRESGSL 204
Query: 449 IMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTE 508
+ GPVVVHCSAGIGR+GTF + D + ++ ++ +D+ K + +R R G++QT
Sbjct: 205 SPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTA 264
Query: 509 AQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLADQTSGDQSPLPPCTPTPP 568
Q RF Y+AV + + + + K HE D P P P PP
Sbjct: 265 DQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHE--------------DLEPPPEHIPPPP 310
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 189 bits (480), Expect = 6e-48
Identities = 112/280 (40%), Positives = 160/280 (57%), Gaps = 21/280 (7%)
Query: 250 EFETLQQQECKLLYSRKEGQRQE-------NKNKNRYKNILPFDHTRVVLHDGDPNEPVS 302
E T + E KLL S K + NK KNR NI+P++ TRV L E S
Sbjct: 1634 ESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG-S 1692
Query: 303 DYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVER 362
DYINA+ + + + +K+YIATQG L + DFWRM+++ NS +IVM TK E
Sbjct: 1693 DYINASFL--------DGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREM 1744
Query: 363 GKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRT 422
G+ KC +YWP E + + Y V + E Y LRE K++ G + RT+ Q+ F
Sbjct: 1745 GREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREFKVTDARDGQS-RTIRQFQFTD 1802
Query: 423 WPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREK 482
WP+ GVP G +DF+ +VH +E GP+ VHCSAG+GRTG FI + I+++ +R +
Sbjct: 1803 WPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE 1862
Query: 483 GVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI 522
GV +D+ +T++ +R+QR MVQTE QY+ Y A Y+
Sbjct: 1863 GV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL 1899
Score = 187 bits (475), Expect = 2e-47
Identities = 110/290 (37%), Positives = 172/290 (59%), Gaps = 23/290 (7%)
Query: 233 LSKLAETTDKVKQG----FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHT 288
++ LA+ +++K F +E+E++ + ++ + + NK KNRY N++ +DH+
Sbjct: 1334 ITDLADNIERLKANDGLKFSQEYESIDPGQ---QFTWENSNLEVNKPKNRYANVIAYDHS 1390
Query: 289 RVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQE 348
RV+L D P SDYINAN I + + + +YIATQG L T+ DFWRMV+++
Sbjct: 1391 RVILTSID-GVPGSDYINANYI--------DGYRKQNAYIATQGPLPETMGDFWRMVWEQ 1441
Query: 349 NSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQ 408
+ +VM T+ E+ + KC +YWP + G+++V + YT+R L K G
Sbjct: 1442 RTATVVMMTRLEEKSRVKCDQYWPAR-GTETCGLIQVTLLDTVELATYTVRTFALHKSG- 1499
Query: 409 GNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGT 468
+ +R + Q+ F WPDHGVP P +L FL V K + +DAGP+VVHCSAG+GRTG
Sbjct: 1500 SSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRV--KACNPLDAGPMVVHCSAGVGRTGC 1557
Query: 469 FIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
FIVID +++ ++ + +D+ + +RSQR+ MVQTE QY FI+ A+
Sbjct: 1558 FIVIDAMLERMKHEKT---VDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1604
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 189 bits (480), Expect = 6e-48
Identities = 112/280 (40%), Positives = 160/280 (57%), Gaps = 21/280 (7%)
Query: 250 EFETLQQQECKLLYSRKEGQRQE-------NKNKNRYKNILPFDHTRVVLHDGDPNEPVS 302
E T + E KLL S K + NK KNR NI+P++ TRV L E S
Sbjct: 1625 ESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEG-S 1683
Query: 303 DYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVER 362
DYINA+ + + + +K+YIATQG L + DFWRM+++ NS +IVM TK E
Sbjct: 1684 DYINASFL--------DGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREM 1735
Query: 363 GKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRT 422
G+ KC +YWP E + + Y V + E Y LRE K++ G + RT+ Q+ F
Sbjct: 1736 GREKCHQYWPAERSAR-YQYFVVDPMAEYNMPQYILREFKVTDARDGQS-RTIRQFQFTD 1793
Query: 423 WPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREK 482
WP+ GVP G +DF+ +VH +E GP+ VHCSAG+GRTG FI + I+++ +R +
Sbjct: 1794 WPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYE 1853
Query: 483 GVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI 522
GV +D+ +T++ +R+QR MVQTE QY+ Y A Y+
Sbjct: 1854 GV---VDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYL 1890
Score = 187 bits (475), Expect = 2e-47
Identities = 110/290 (37%), Positives = 172/290 (59%), Gaps = 23/290 (7%)
Query: 233 LSKLAETTDKVKQG----FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHT 288
++ LA+ +++K F +E+E++ + ++ + + NK KNRY N++ +DH+
Sbjct: 1325 ITDLADNIERLKANDGLKFSQEYESIDPGQ---QFTWENSNLEVNKPKNRYANVIAYDHS 1381
Query: 289 RVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQE 348
RV+L D P SDYINAN I + + + +YIATQG L T+ DFWRMV+++
Sbjct: 1382 RVILTSID-GVPGSDYINANYI--------DGYRKQNAYIATQGPLPETMGDFWRMVWEQ 1432
Query: 349 NSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQ 408
+ +VM T+ E+ + KC +YWP + G+++V + YT+R L K G
Sbjct: 1433 RTATVVMMTRLEEKSRVKCDQYWPAR-GTETCGLIQVTLLDTVELATYTVRTFALHKSG- 1490
Query: 409 GNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGT 468
+ +R + Q+ F WPDHGVP P +L FL V K + +DAGP+VVHCSAG+GRTG
Sbjct: 1491 SSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRV--KACNPLDAGPMVVHCSAGVGRTGC 1548
Query: 469 FIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV 518
FIVID +++ ++ + +D+ + +RSQR+ MVQTE QY FI+ A+
Sbjct: 1549 FIVIDAMLERMKHEKT---VDIYGHVTCMRSQRNYMVQTEDQYVFIHEAL 1595
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,389,792
Number of Sequences: 37866
Number of extensions: 1087229
Number of successful extensions: 4682
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 187
Number of HSP's successfully gapped in prelim test: 95
Number of HSP's that attempted gapping in prelim test: 3643
Number of HSP's gapped (non-prelim): 513
length of query: 593
length of database: 18,247,518
effective HSP length: 108
effective length of query: 485
effective length of database: 14,157,990
effective search space: 6866625150
effective search space used: 6866625150
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.