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Search of human proteins with 31542768
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31542768 homeodomain interacting protein kinase 4 [Homo
sapiens]
(616 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 1264 0.0
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 335 1e-91
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 335 1e-91
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 333 3e-91
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 333 3e-91
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 322 6e-88
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 322 6e-88
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 200 4e-51
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 200 4e-51
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 200 4e-51
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 200 4e-51
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 200 4e-51
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 195 9e-50
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 192 8e-49
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 184 3e-46
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 181 2e-45
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 180 4e-45
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 180 4e-45
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 179 5e-45
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 179 5e-45
gi|169171014 PREDICTED: similar to homeodomain interacting prote... 171 2e-42
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 145 1e-34
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 145 1e-34
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 141 2e-33
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 141 2e-33
gi|10190706 CDC-like kinase 4 [Homo sapiens] 141 2e-33
gi|27477122 intestinal cell kinase [Homo sapiens] 135 1e-31
gi|7662388 intestinal cell kinase [Homo sapiens] 135 1e-31
gi|38201642 homeodomain-interacting protein kinase 1 isoform 3 [... 135 1e-31
gi|11496279 male germ cell-associated kinase [Homo sapiens] 135 1e-31
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 1264 bits (3270), Expect = 0.0
Identities = 616/616 (100%), Positives = 616/616 (100%)
Query: 1 MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLH 60
MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLH
Sbjct: 1 MSTIQSETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLH 60
Query: 61 CMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQV 120
CMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQV
Sbjct: 61 CMRGLDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQV 120
Query: 121 LTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRF 180
LTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRF
Sbjct: 121 LTALARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRF 180
Query: 181 YRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLH 240
YRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLH
Sbjct: 181 YRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLH 240
Query: 241 AACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVA 300
AACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVA
Sbjct: 241 AACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVA 300
Query: 301 SRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
SRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH
Sbjct: 301 SRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
Query: 361 YYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAP 420
YYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAP
Sbjct: 361 YYQLSLRSYRLSLQVEGKPPTPVVAAEDGTPYYCLAEEKEAAGMGSVAGSSPFFREEKAP 420
Query: 421 GMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSS 480
GMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSS
Sbjct: 421 GMQRAIDQLDDLSLQEAGHGLWGETCTNAVSDMMVPLKAAITGHHVPDSGPEPILAFYSS 480
Query: 481 RLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQ 540
RLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQ
Sbjct: 481 RLAGRHKARKPPAGSKSDSNFSNLIRLSQVSPEDDRPCRGSSWEEGEHLGASAEPLAILQ 540
Query: 541 RDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHG 600
RDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHG
Sbjct: 541 RDEDGPNIDNMTMEAERPDPELFDPSSCPGEWLSEPDCTLESVRGPRAQGLPPRRSHQHG 600
Query: 601 PPRGATSFLQHVTGHH 616
PPRGATSFLQHVTGHH
Sbjct: 601 PPRGATSFLQHVTGHH 616
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 335 bits (858), Expect = 1e-91
Identities = 178/356 (50%), Positives = 237/356 (66%), Gaps = 10/356 (2%)
Query: 6 SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65
S T+ Y+++E LG+GTFG+V K W+R T E+VAIKILKN R + E+ +L +
Sbjct: 194 SMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 253
Query: 66 DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125
++ + +R E F LVFE+LEQNL++F K+N F+PLP ++IR V QV TAL
Sbjct: 254 SADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALM 313
Query: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
+LK L +IHADLKPENIMLVD +R P+RVKVIDFGSAS S+ V Y+QSR+YRAPE
Sbjct: 314 KLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKA--VCSTYLQSRYYRAPE 371
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG +EYDQ+RYI +TQGLP +LL A K
Sbjct: 372 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKT 431
Query: 246 HHFFKRNPHPDAANP-WQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLT 304
FF R+ D+ P W+LK+ D+ AET ++ E RKY+ LD + VN
Sbjct: 432 TRFFNRD--TDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN-----MTTD 484
Query: 305 FPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
+ L E AD + ++L+K+MLT ++ +RI+P L HPFV+M L +TH
Sbjct: 485 LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 335 bits (858), Expect = 1e-91
Identities = 178/356 (50%), Positives = 237/356 (66%), Gaps = 10/356 (2%)
Query: 6 SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65
S T+ Y+++E LG+GTFG+V K W+R T E+VAIKILKN R + E+ +L +
Sbjct: 194 SMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 253
Query: 66 DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125
++ + +R E F LVFE+LEQNL++F K+N F+PLP ++IR V QV TAL
Sbjct: 254 SADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALM 313
Query: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
+LK L +IHADLKPENIMLVD +R P+RVKVIDFGSAS S+ V Y+QSR+YRAPE
Sbjct: 314 KLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKA--VCSTYLQSRYYRAPE 371
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG +EYDQ+RYI +TQGLP +LL A K
Sbjct: 372 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKT 431
Query: 246 HHFFKRNPHPDAANP-WQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLT 304
FF R+ D+ P W+LK+ D+ AET ++ E RKY+ LD + VN
Sbjct: 432 TRFFNRD--TDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN-----MTTD 484
Query: 305 FPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
+ L E AD + ++L+K+MLT ++ +RI+P L HPFV+M L +TH
Sbjct: 485 LEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTH 540
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 333 bits (854), Expect = 3e-91
Identities = 177/356 (49%), Positives = 238/356 (66%), Gaps = 10/356 (2%)
Query: 6 SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65
S T+ Y+++E LG+GTFG+VAK W+RST E+VAIKILKN R + E+ +L +
Sbjct: 185 SMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSE 244
Query: 66 DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125
+ +E + +R E F LVFE+LEQNL++F K+N F+PLP ++IR + QV TAL
Sbjct: 245 NADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALM 304
Query: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
+LK L +IHADLKPENIMLVD R P+RVKVIDFGSAS S+ V Y+QSR+YRAPE
Sbjct: 305 KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKA--VCSTYLQSRYYRAPE 362
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG +EYDQ+RYI +TQGLP +LL A K
Sbjct: 363 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKT 422
Query: 246 HHFFKRNPHPDAANP-WQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLT 304
FF R+ P+ P W+LK+ ++ ET ++ E RKY+ LD + VN +
Sbjct: 423 TRFFNRD--PNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMST-----D 475
Query: 305 FPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
+ LAE AD + ++L+K+MLT ++ +RI+P L H FV+M L + H
Sbjct: 476 LEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNH 531
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 333 bits (854), Expect = 3e-91
Identities = 177/356 (49%), Positives = 238/356 (66%), Gaps = 10/356 (2%)
Query: 6 SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65
S T+ Y+++E LG+GTFG+VAK W+RST E+VAIKILKN R + E+ +L +
Sbjct: 185 SMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSSE 244
Query: 66 DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125
+ +E + +R E F LVFE+LEQNL++F K+N F+PLP ++IR + QV TAL
Sbjct: 245 NADEYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALM 304
Query: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
+LK L +IHADLKPENIMLVD R P+RVKVIDFGSAS S+ V Y+QSR+YRAPE
Sbjct: 305 KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKA--VCSTYLQSRYYRAPE 362
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG +EYDQ+RYI +TQGLP +LL A K
Sbjct: 363 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKT 422
Query: 246 HHFFKRNPHPDAANP-WQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLT 304
FF R+ P+ P W+LK+ ++ ET ++ E RKY+ LD + VN +
Sbjct: 423 TRFFNRD--PNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMST-----D 475
Query: 305 FPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
+ LAE AD + ++L+K+MLT ++ +RI+P L H FV+M L + H
Sbjct: 476 LEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNH 531
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 322 bits (825), Expect = 6e-88
Identities = 172/355 (48%), Positives = 233/355 (65%), Gaps = 8/355 (2%)
Query: 6 SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65
S + Y++++ LG+GTFG+V K W+R T E+VAIKILKN R + E+ +L +
Sbjct: 192 SMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 251
Query: 66 DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125
+ +E + +R E F LVFE+LEQNL++F K+N F+PLP + IR + QV TAL
Sbjct: 252 NADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALK 311
Query: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
+LK L +IHADLKPENIMLVD R P+RVKVIDFGSAS S+ V Y+QSR+YRAPE
Sbjct: 312 KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKT--VCSTYLQSRYYRAPE 369
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG EYDQ+RYI +TQGLP LL+ K+
Sbjct: 370 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKS 429
Query: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305
FF + + W+LK+ ++ AET ++ E RKY+ SLD + VN + +
Sbjct: 430 TRFFCKETDMSHSG-WRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVN-----TVMDL 483
Query: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
+ LAE AD + V L+K+ML ++ RI+P+ L HPFV+M+ L + H
Sbjct: 484 EGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNH 538
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 322 bits (825), Expect = 6e-88
Identities = 172/355 (48%), Positives = 233/355 (65%), Gaps = 8/355 (2%)
Query: 6 SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65
S + Y++++ LG+GTFG+V K W+R T E+VAIKILKN R + E+ +L +
Sbjct: 192 SMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 251
Query: 66 DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125
+ +E + +R E F LVFE+LEQNL++F K+N F+PLP + IR + QV TAL
Sbjct: 252 NADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALK 311
Query: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
+LK L +IHADLKPENIMLVD R P+RVKVIDFGSAS S+ V Y+QSR+YRAPE
Sbjct: 312 KLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKT--VCSTYLQSRYYRAPE 369
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
I+LGLPFCE +D+WSLGCV+AEL LGWPLYPG EYDQ+RYI +TQGLP LL+ K+
Sbjct: 370 IILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKS 429
Query: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305
FF + + W+LK+ ++ AET ++ E RKY+ SLD + VN + +
Sbjct: 430 TRFFCKETDMSHSG-WRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVN-----TVMDL 483
Query: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
+ LAE AD + V L+K+ML ++ RI+P+ L HPFV+M+ L + H
Sbjct: 484 EGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNH 538
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 200 bits (508), Expect = 4e-51
Identities = 129/341 (37%), Positives = 183/341 (53%), Gaps = 22/341 (6%)
Query: 9 DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE 68
D Y+I ++GKG+FG+V K + R E VAIKI+KN + E++LL M D E
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
Query: 69 -EAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARL 127
+ +++ F LVFE+L NL++ + NF + R Q+ TAL L
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
Query: 128 K--ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPE 331
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
+LLG+P+ +D+WSLGC++ E+H G PL+ G NE DQ+ I E G+P H+L A KA
Sbjct: 332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 391
Query: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305
FF++ P W LK + D + + +P RK L I V G R
Sbjct: 392 RKFFEKLPD----GTWNLKKTKD--GKREYKPPGTRK-----LHNILGVETGGPGGRRAG 440
Query: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346
+A++ K +LI RML ++ RI P AL+H F
Sbjct: 441 ESGHTVADYLKFK---DLILRMLDYDPKTRIQPYYALQHSF 478
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 200 bits (508), Expect = 4e-51
Identities = 129/341 (37%), Positives = 183/341 (53%), Gaps = 22/341 (6%)
Query: 9 DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE 68
D Y+I ++GKG+FG+V K + R E VAIKI+KN + E++LL M D E
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
Query: 69 -EAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARL 127
+ +++ F LVFE+L NL++ + NF + R Q+ TAL L
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
Query: 128 K--ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPE 331
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
+LLG+P+ +D+WSLGC++ E+H G PL+ G NE DQ+ I E G+P H+L A KA
Sbjct: 332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 391
Query: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305
FF++ P W LK + D + + +P RK L I V G R
Sbjct: 392 RKFFEKLPD----GTWNLKKTKD--GKREYKPPGTRK-----LHNILGVETGGPGGRRAG 440
Query: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346
+A++ K +LI RML ++ RI P AL+H F
Sbjct: 441 ESGHTVADYLKFK---DLILRMLDYDPKTRIQPYYALQHSF 478
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 200 bits (508), Expect = 4e-51
Identities = 129/341 (37%), Positives = 183/341 (53%), Gaps = 22/341 (6%)
Query: 9 DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE 68
D Y+I ++GKG+FG+V K + R E VAIKI+KN + E++LL M D E
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
Query: 69 -EAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARL 127
+ +++ F LVFE+L NL++ + NF + R Q+ TAL L
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
Query: 128 K--ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPE 331
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
+LLG+P+ +D+WSLGC++ E+H G PL+ G NE DQ+ I E G+P H+L A KA
Sbjct: 332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 391
Query: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305
FF++ P W LK + D + + +P RK L I V G R
Sbjct: 392 RKFFEKLPD----GTWNLKKTKD--GKREYKPPGTRK-----LHNILGVETGGPGGRRAG 440
Query: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346
+A++ K +LI RML ++ RI P AL+H F
Sbjct: 441 ESGHTVADYLKFK---DLILRMLDYDPKTRIQPYYALQHSF 478
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 200 bits (508), Expect = 4e-51
Identities = 129/341 (37%), Positives = 183/341 (53%), Gaps = 22/341 (6%)
Query: 9 DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE 68
D Y+I ++GKG+FG+V K + R E VAIKI+KN + E++LL M D E
Sbjct: 148 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 207
Query: 69 -EAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARL 127
+ +++ F LVFE+L NL++ + NF + R Q+ TAL L
Sbjct: 208 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 267
Query: 128 K--ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE
Sbjct: 268 ATPELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPE 322
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
+LLG+P+ +D+WSLGC++ E+H G PL+ G NE DQ+ I E G+P H+L A KA
Sbjct: 323 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 382
Query: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305
FF++ P W LK + D + + +P RK L I V G R
Sbjct: 383 RKFFEKLPD----GTWNLKKTKD--GKREYKPPGTRK-----LHNILGVETGGPGGRRAG 431
Query: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346
+A++ K +LI RML ++ RI P AL+H F
Sbjct: 432 ESGHTVADYLKFK---DLILRMLDYDPKTRIQPYYALQHSF 469
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 200 bits (508), Expect = 4e-51
Identities = 129/341 (37%), Positives = 183/341 (53%), Gaps = 22/341 (6%)
Query: 9 DCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE 68
D Y+I ++GKG+FG+V K + R E VAIKI+KN + E++LL M D E
Sbjct: 157 DRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTE 216
Query: 69 -EAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARL 127
+ +++ F LVFE+L NL++ + NF + R Q+ TAL L
Sbjct: 217 MKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFL 276
Query: 128 K--ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPE 185
EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE
Sbjct: 277 ATPELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPE 331
Query: 186 ILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKA 245
+LLG+P+ +D+WSLGC++ E+H G PL+ G NE DQ+ I E G+P H+L A KA
Sbjct: 332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKA 391
Query: 246 HHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTF 305
FF++ P W LK + D + + +P RK L I V G R
Sbjct: 392 RKFFEKLPD----GTWNLKKTKD--GKREYKPPGTRK-----LHNILGVETGGPGGRRAG 440
Query: 306 PDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346
+A++ K +LI RML ++ RI P AL+H F
Sbjct: 441 ESGHTVADYLKFK---DLILRMLDYDPKTRIQPYYALQHSF 478
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 195 bits (496), Expect = 9e-50
Identities = 133/353 (37%), Positives = 191/353 (54%), Gaps = 26/353 (7%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE-E 69
Y+I ++GKG+FG+V K + T E+VAIKI+KN + EL+LL M D E +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 70 AHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK- 128
+++ F LVFELL NL++ + +F + R + Q+ TAL L
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 129 -ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEIL 187
EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE+L
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPEVL 285
Query: 188 LGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHH 247
LG P+ +D+WSLGC++ E+H G PL+ G+NE DQ+ I E G+P +L A KA
Sbjct: 286 LGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARK 345
Query: 248 FFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPD 307
+F+R P W L+ + + L + P RR L+ + ++T GG R P
Sbjct: 346 YFERLP----GGGWTLRRTKE-LRKDYQGPGTRR---LQEVLGVQT--GGPGGRRAGEPG 395
Query: 308 REALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
AD +L+ RML +E RISP AL+H F R+A E T+
Sbjct: 396 HSP----ADYLRFQDLVLRMLEYEPAARISPLGALQHGFFR----RTADEATN 440
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 192 bits (488), Expect = 8e-49
Identities = 117/338 (34%), Positives = 174/338 (51%), Gaps = 42/338 (12%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Y+++E +GKG+FG+VAK E+VA+KI++N ++ ELK+L +R D +
Sbjct: 104 YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNT 163
Query: 71 H-VIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKE 129
+ V+ +FF+ F + FELL NL+E K NNF +R TL VL L L
Sbjct: 164 YNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSV 223
Query: 130 LAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLG 189
IIH DLKPENI+L + + VKVIDFGS+ + Y YIQSRFYR+PE++LG
Sbjct: 224 EKIIHCDLKPENIVLYQKGQAS--VKVIDFGSSCYEHQKVYT---YIQSRFYRSPEVILG 278
Query: 190 LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFF 249
P+ +D+WSLGC+ AEL+ G+PL+PG NE +Q+ I E GLP + A + FF
Sbjct: 279 HPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFF 338
Query: 250 KRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDRE 309
P K+ + + + + +LK+ D
Sbjct: 339 DSKGFP--------KNITNNRGKKRYPDSKDLTMVLKTYD-------------------- 370
Query: 310 ALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV 347
S ++ ++R L WE R++P AL+H ++
Sbjct: 371 --------TSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 184 bits (466), Expect = 3e-46
Identities = 126/353 (35%), Positives = 180/353 (50%), Gaps = 54/353 (15%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE-E 69
Y+I ++GKG+FG+V K + T E+VAIKI+KN + EL+LL M D E +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 70 AHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK- 128
+++ F LVFELL NL++ + +F + R + Q+ TAL L
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 129 -ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEIL 187
EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE+L
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPEVL 285
Query: 188 LGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHH 247
LG P+ +D+WSLGC++ E+H G PL+ G+NE DQ+ I E G+P +L A KA
Sbjct: 286 LGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARK 345
Query: 248 FFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPD 307
+F+R P W L+ + + R+ Y P
Sbjct: 346 YFERLP----GGGWTLRRTKEL----------RKDYQ--------------------GPG 371
Query: 308 REALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
L E +L+ RML +E RISP AL+H F R+A E T+
Sbjct: 372 TRRLQE--------DLVLRMLEYEPAARISPLGALQHGFFR----RTADEATN 412
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 181 bits (459), Expect = 2e-45
Identities = 107/272 (39%), Positives = 156/272 (57%), Gaps = 12/272 (4%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPE-E 69
Y+I ++GKG+FG+V K + T E+VAIKI+KN + EL+LL M D E +
Sbjct: 111 YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK 170
Query: 70 AHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK- 128
+++ F LVFELL NL++ + +F + R + Q+ TAL L
Sbjct: 171 YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT 230
Query: 129 -ELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEIL 187
EL+IIH DLKPENI+L + R +K++DFGS+ + Y YIQSRFYR+PE+L
Sbjct: 231 PELSIIHCDLKPENILLCNPKRSA--IKIVDFGSSCQLGQRIY---QYIQSRFYRSPEVL 285
Query: 188 LGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHH 247
LG P+ +D+WSLGC++ E+H G PL+ G+NE DQ+ I E G+P +L A KA
Sbjct: 286 LGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARK 345
Query: 248 FFKRNPHPDAANPWQLKSSADYLAETKVRPLE 279
+F+R P W L+ + + + +R LE
Sbjct: 346 YFERLP----GGGWTLRRTKELRKDLVLRMLE 373
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 180 bits (456), Expect = 4e-45
Identities = 113/339 (33%), Positives = 177/339 (52%), Gaps = 25/339 (7%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Y++++++GKG+FG+VA+ + + VA+K+++N+ +R E+++L ++ D +
Sbjct: 189 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 248
Query: 71 -HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKE 129
+VI LE F + FELL +L+E K+N F + +R +L +L L +
Sbjct: 249 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 308
Query: 130 LAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLG 189
IIH DLKPENI+L R KVIDFGS+ + Y YIQSRFYRAPEI+LG
Sbjct: 309 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLYT---YIQSRFYRAPEIILG 363
Query: 190 LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFF 249
+ +D+WS GC++AEL G PL+PG +E DQ+ + E G+P P LL + +A +F
Sbjct: 364 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 423
Query: 250 KRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDRE 309
P + L + R ++R G S+ D
Sbjct: 424 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKR---------------GPPGSK----DWG 464
Query: 310 ALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVS 348
+ D +E +KR L W+ R++P+ ALRHP++S
Sbjct: 465 TALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 503
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 180 bits (456), Expect = 4e-45
Identities = 113/339 (33%), Positives = 177/339 (52%), Gaps = 25/339 (7%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Y++++++GKG+FG+VA+ + + VA+K+++N+ +R E+++L ++ D +
Sbjct: 209 YEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQDKTGS 268
Query: 71 -HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKE 129
+VI LE F + FELL +L+E K+N F + +R +L +L L +
Sbjct: 269 MNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328
Query: 130 LAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLG 189
IIH DLKPENI+L R KVIDFGS+ + Y YIQSRFYRAPEI+LG
Sbjct: 329 NKIIHCDLKPENILLKHHGRSS--TKVIDFGSSCFEYQKLYT---YIQSRFYRAPEIILG 383
Query: 190 LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFF 249
+ +D+WS GC++AEL G PL+PG +E DQ+ + E G+P P LL + +A +F
Sbjct: 384 SRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKLLEQSKRAKYFI 443
Query: 250 KRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDRE 309
P + L + R ++R G S+ D
Sbjct: 444 NSKGIPRYCSVTTQADGRVVLVGGRSRRGKKR---------------GPPGSK----DWG 484
Query: 310 ALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVS 348
+ D +E +KR L W+ R++P+ ALRHP++S
Sbjct: 485 TALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWIS 523
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 179 bits (455), Expect = 5e-45
Identities = 116/343 (33%), Positives = 175/343 (51%), Gaps = 35/343 (10%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Y++++V+GKG+FG+V K + + VA+K+++N+ +R E+++L +R D +
Sbjct: 222 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT 281
Query: 71 -HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKE 129
+VI LE F + FELL NL+E K+N F +R +L L L +
Sbjct: 282 MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK 341
Query: 130 LAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLG 189
IIH DLKPENI+L Q R +KVIDFGS+ + Y YIQSRFYRAPE++LG
Sbjct: 342 NRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVYT---YIQSRFYRAPEVILG 396
Query: 190 LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFF 249
+ +D+WSLGC++AEL G+PL PG +E DQ+ + E G+P LL A+ +A +F
Sbjct: 397 ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFV 456
Query: 250 KRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGG-SVASRLTFPDR 308
+P L D +NGG S +L P
Sbjct: 457 SSKGYPRYCTVTTLS------------------------DGSVVLNGGRSRRGKLRGPPE 492
Query: 309 EA----LAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV 347
+ D ++ +K+ L W+ R++P ALRHP++
Sbjct: 493 SREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 535
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 179 bits (455), Expect = 5e-45
Identities = 116/343 (33%), Positives = 175/343 (51%), Gaps = 35/343 (10%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Y++++V+GKG+FG+V K + + VA+K+++N+ +R E+++L +R D +
Sbjct: 149 YEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNT 208
Query: 71 -HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKE 129
+VI LE F + FELL NL+E K+N F +R +L L L +
Sbjct: 209 MNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSLPLVRKFAHSILQCLDALHK 268
Query: 130 LAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLG 189
IIH DLKPENI+L Q R +KVIDFGS+ + Y YIQSRFYRAPE++LG
Sbjct: 269 NRIIHCDLKPENILLKQQGRSG--IKVIDFGSSCYEHQRVYT---YIQSRFYRAPEVILG 323
Query: 190 LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFF 249
+ +D+WSLGC++AEL G+PL PG +E DQ+ + E G+P LL A+ +A +F
Sbjct: 324 ARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKLLDASKRAKNFV 383
Query: 250 KRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGG-SVASRLTFPDR 308
+P L D +NGG S +L P
Sbjct: 384 SSKGYPRYCTVTTLS------------------------DGSVVLNGGRSRRGKLRGPPE 419
Query: 309 EA----LAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV 347
+ D ++ +K+ L W+ R++P ALRHP++
Sbjct: 420 SREWGNALKGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWL 462
>gi|169171014 PREDICTED: similar to homeodomain interacting protein
kinase 2 [Homo sapiens]
Length = 460
Score = 171 bits (432), Expect = 2e-42
Identities = 92/177 (51%), Positives = 122/177 (68%), Gaps = 2/177 (1%)
Query: 6 SETDCYDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGL 65
S T+ Y+++E LG+GTFG+V K W+R T E+VAIKILKN R + E+ +L +
Sbjct: 194 SMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTE 253
Query: 66 DPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALA 125
++ + +R E F LVFE+LEQNL++F K+N F+PLP ++IR V QV TAL
Sbjct: 254 SADDYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALM 313
Query: 126 RLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYR 182
+LK L +IHADLKPENIMLVD +R P+RVKVIDFGSAS S+ V Y+QSR+YR
Sbjct: 314 KLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSASHVSKA--VCSTYLQSRYYR 368
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 145 bits (365), Expect = 1e-34
Identities = 99/356 (27%), Positives = 174/356 (48%), Gaps = 54/356 (15%)
Query: 11 YDIIEVLGKGTFGEVAKGW-RRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEE 69
Y+I++ LG+G FG+V + ++ G VA+KI+KN ++E+++L + DP
Sbjct: 203 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 262
Query: 70 A-HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK 128
++ LE+F +VFELL + ++F KEN F P HIR + Q+ ++ L
Sbjct: 263 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 322
Query: 129 ELAIIHADLKPENIMLV---------------DQTRCPFRVKVIDFGSASIFSEVRYVKE 173
+ H DLKPENI+ V ++T +KV+DFGSA+ E
Sbjct: 323 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHH---S 379
Query: 174 PYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGL 233
+ +R YRAPE++L L + + DVWS+GC++ E +LG+ ++P ++ + + + G
Sbjct: 380 TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGP 439
Query: 234 PKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIET 293
H++ K +F H D + W SSA + +PL +++M
Sbjct: 440 LPKHMIQKTRKRKYF-----HHDRLD-WDEHSSAGRYVSRRCKPL--KEFM--------- 482
Query: 294 VNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSM 349
L++ + + + +LI++ML ++ +RI+ AL+HPF +
Sbjct: 483 -----------------LSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 521
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 145 bits (365), Expect = 1e-34
Identities = 99/356 (27%), Positives = 174/356 (48%), Gaps = 54/356 (15%)
Query: 11 YDIIEVLGKGTFGEVAKGW-RRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEE 69
Y+I++ LG+G FG+V + ++ G VA+KI+KN ++E+++L + DP
Sbjct: 161 YEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNS 220
Query: 70 A-HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK 128
++ LE+F +VFELL + ++F KEN F P HIR + Q+ ++ L
Sbjct: 221 TFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLH 280
Query: 129 ELAIIHADLKPENIMLV---------------DQTRCPFRVKVIDFGSASIFSEVRYVKE 173
+ H DLKPENI+ V ++T +KV+DFGSA+ E
Sbjct: 281 SNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHH---S 337
Query: 174 PYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGL 233
+ +R YRAPE++L L + + DVWS+GC++ E +LG+ ++P ++ + + + G
Sbjct: 338 TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGP 397
Query: 234 PKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIET 293
H++ K +F H D + W SSA + +PL +++M
Sbjct: 398 LPKHMIQKTRKRKYF-----HHDRLD-WDEHSSAGRYVSRRCKPL--KEFM--------- 440
Query: 294 VNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSM 349
L++ + + + +LI++ML ++ +RI+ AL+HPF +
Sbjct: 441 -----------------LSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDL 479
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 141 bits (356), Expect = 2e-33
Identities = 103/353 (29%), Positives = 170/353 (48%), Gaps = 54/353 (15%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGE-MVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEE 69
Y+I+ LG+GTFG+V + + G+ VA+KI++N + E+ +L ++ D E
Sbjct: 304 YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKEN 363
Query: 70 AHV-IRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK 128
+ + ++F+ + FELL +N FEF KENNF P P H+R + Q+ AL L
Sbjct: 364 KFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLH 423
Query: 129 ELAIIHADLKPENIMLV---------DQTRCPFR------VKVIDFGSASIFSEVRYVKE 173
E + H DLKPENI+ V + C + ++V DFGSA+ E
Sbjct: 424 ENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHH---T 480
Query: 174 PYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGL 233
+ +R YR PE++L L + + DVWS+GC++ E + G+ L+ + + + + + G
Sbjct: 481 TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP 540
Query: 234 PKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIET 293
H++H K +F+K W SS + +PL + YML+ D +E
Sbjct: 541 IPSHMIHRTRKQKYFYK------GGLVWDENSSDGRYVKENCKPL--KSYMLQ--DSLEH 590
Query: 294 VNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346
V + +L++RML ++ +RI+ + AL HPF
Sbjct: 591 V------------------------QLFDLMRRMLEFDPAQRITLAEALLHPF 619
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 141 bits (356), Expect = 2e-33
Identities = 103/353 (29%), Positives = 170/353 (48%), Gaps = 54/353 (15%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGE-MVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEE 69
Y+I+ LG+GTFG+V + + G+ VA+KI++N + E+ +L ++ D E
Sbjct: 156 YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKEN 215
Query: 70 AHV-IRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK 128
+ + ++F+ + FELL +N FEF KENNF P P H+R + Q+ AL L
Sbjct: 216 KFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLH 275
Query: 129 ELAIIHADLKPENIMLV---------DQTRCPFR------VKVIDFGSASIFSEVRYVKE 173
E + H DLKPENI+ V + C + ++V DFGSA+ E
Sbjct: 276 ENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHH---T 332
Query: 174 PYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGL 233
+ +R YR PE++L L + + DVWS+GC++ E + G+ L+ + + + + + G
Sbjct: 333 TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP 392
Query: 234 PKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIET 293
H++H K +F+K W SS + +PL + YML+ D +E
Sbjct: 393 IPSHMIHRTRKQKYFYK------GGLVWDENSSDGRYVKENCKPL--KSYMLQ--DSLEH 442
Query: 294 VNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPF 346
V + +L++RML ++ +RI+ + AL HPF
Sbjct: 443 V------------------------QLFDLMRRMLEFDPAQRITLAEALLHPF 471
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 141 bits (355), Expect = 2e-33
Identities = 97/356 (27%), Positives = 170/356 (47%), Gaps = 54/356 (15%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEM-VAIKILKNDAYRNRIIKNELKLLHCMRGLDPEE 69
Y+I++ LG+G FG+V + M VA+KI+KN ++E+++L + DP
Sbjct: 159 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 218
Query: 70 A-HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK 128
++ LE+F +VFELL + ++F KEN+F P HIR + Q+ ++ L
Sbjct: 219 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLH 278
Query: 129 ELAIIHADLKPENIMLV---------------DQTRCPFRVKVIDFGSASIFSEVRYVKE 173
+ H DLKPENI+ V ++T +KV+DFGSA+ E
Sbjct: 279 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHH---S 335
Query: 174 PYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGL 233
+ +R YRAPE++L L + + DVWS+GC++ E +LG+ ++ ++ + + + G
Sbjct: 336 TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGP 395
Query: 234 PKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIET 293
H++ K +F H + + W SSA + +PL +++M
Sbjct: 396 IPQHMIQKTRKRKYF-----HHNQLD-WDEHSSAGRYVRRRCKPL--KEFM--------- 438
Query: 294 VNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSM 349
L + + + +L++RML ++ +RI+ AL+HPF +
Sbjct: 439 -----------------LCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDL 477
>gi|27477122 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 135 bits (340), Expect = 1e-31
Identities = 113/372 (30%), Positives = 174/372 (46%), Gaps = 62/372 (16%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Y I LG GT+G V G +GE++AIK +K Y N L+ + ++ L+ A
Sbjct: 4 YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMN-LREVKSLKKLN--HA 60
Query: 71 HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKEL 130
+V++ E + Y +FE +++NL++ KE N P IR + Q+L LA + +
Sbjct: 61 NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKL-FPESAIRNIMYQILQGLAFIHKH 119
Query: 131 AIIHADLKPENIMLVDQTRCPFRVKVIDFGSA-SIFSEVRYVKEPYIQSRFYRAPEILL- 188
H DLKPEN++ + P VK+ DFG A I S+ Y Y+ +R+YRAPE+LL
Sbjct: 120 GFFHRDLKPENLLCMG----PELVKIADFGLAREIRSKPPYTD--YVSTRWYRAPEVLLR 173
Query: 189 GLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHF 248
+ +DVW++GC+MAE++ PL+PG +E D + IC+ G PK
Sbjct: 174 STNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPK------------- 220
Query: 249 FKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDR 308
D +QL S+ ++ R + LK+L N S A
Sbjct: 221 -----KTDWPEGYQLSSAMNF------RWPQCVPNNLKTL----IPNASSEA-------- 257
Query: 309 EALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTHYYQLSLRS 368
V+L++ ML W+ +R + S ALR+P+ Q TT Q S +
Sbjct: 258 ------------VQLLRDMLQWDPKKRPTASQALRYPY--FQVGHPLGSTTQNLQDSEKP 303
Query: 369 YRLSLQVEGKPP 380
+ L+ G PP
Sbjct: 304 QKGILEKAGPPP 315
>gi|7662388 intestinal cell kinase [Homo sapiens]
Length = 632
Score = 135 bits (340), Expect = 1e-31
Identities = 113/372 (30%), Positives = 174/372 (46%), Gaps = 62/372 (16%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Y I LG GT+G V G +GE++AIK +K Y N L+ + ++ L+ A
Sbjct: 4 YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMN-LREVKSLKKLN--HA 60
Query: 71 HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKEL 130
+V++ E + Y +FE +++NL++ KE N P IR + Q+L LA + +
Sbjct: 61 NVVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKL-FPESAIRNIMYQILQGLAFIHKH 119
Query: 131 AIIHADLKPENIMLVDQTRCPFRVKVIDFGSA-SIFSEVRYVKEPYIQSRFYRAPEILL- 188
H DLKPEN++ + P VK+ DFG A I S+ Y Y+ +R+YRAPE+LL
Sbjct: 120 GFFHRDLKPENLLCMG----PELVKIADFGLAREIRSKPPYTD--YVSTRWYRAPEVLLR 173
Query: 189 GLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHF 248
+ +DVW++GC+MAE++ PL+PG +E D + IC+ G PK
Sbjct: 174 STNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPK------------- 220
Query: 249 FKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDR 308
D +QL S+ ++ R + LK+L N S A
Sbjct: 221 -----KTDWPEGYQLSSAMNF------RWPQCVPNNLKTL----IPNASSEA-------- 257
Query: 309 EALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTHYYQLSLRS 368
V+L++ ML W+ +R + S ALR+P+ Q TT Q S +
Sbjct: 258 ------------VQLLRDMLQWDPKKRPTASQALRYPY--FQVGHPLGSTTQNLQDSEKP 303
Query: 369 YRLSLQVEGKPP 380
+ L+ G PP
Sbjct: 304 QKGILEKAGPPP 315
>gi|38201642 homeodomain-interacting protein kinase 1 isoform 3
[Homo sapiens]
Length = 836
Score = 135 bits (340), Expect = 1e-31
Identities = 71/164 (43%), Positives = 100/164 (60%), Gaps = 8/164 (4%)
Query: 198 VWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFFKRNPHPDA 257
+WSLGCV+AEL LGWPLYPG +EYDQ+RYI +TQGLP +LL A K FF R+ P+
Sbjct: 1 MWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFFNRD--PNL 58
Query: 258 ANP-WQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDREALAEHAD 316
P W+LK+ ++ ET ++ E RKY+ LD + VN + + LAE AD
Sbjct: 59 GYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNMST-----DLEGTDMLAEKAD 113
Query: 317 LKSMVELIKRMLTWESHERISPSAALRHPFVSMQQLRSAHETTH 360
+ ++L+K+MLT ++ +RI+P L H FV+M L + H
Sbjct: 114 RREYIDLLKKMLTIDADKRITPLKTLNHQFVTMTHLLDFPHSNH 157
>gi|11496279 male germ cell-associated kinase [Homo sapiens]
Length = 623
Score = 135 bits (340), Expect = 1e-31
Identities = 112/396 (28%), Positives = 180/396 (45%), Gaps = 79/396 (19%)
Query: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAY------RNRIIKNELKLLHCMRG 64
Y + LG GT+G V G +GE+VAIK +K Y R +K+ KL H
Sbjct: 4 YTTMRQLGDGTYGSVLMGKSNESGELVAIKRMKRKFYSWDECMNLREVKSLKKLNH---- 59
Query: 65 LDPEEAHVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTAL 124
A+VI+ E + Y +FE +++NL++ K+ N P IR + Q+L L
Sbjct: 60 -----ANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRNKL-FPESVIRNIMYQILQGL 113
Query: 125 ARLKELAIIHADLKPENIMLVDQTRCPFRVKVIDFGSA-SIFSEVRYVKEPYIQSRFYRA 183
A + + H D+KPEN++ + P VK+ DFG A + S+ Y Y+ +R+YRA
Sbjct: 114 AFIHKHGFFHRDMKPENLLCMG----PELVKIADFGLARELRSQPPYTD--YVSTRWYRA 167
Query: 184 PEILL-GLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAA 242
PE+LL + +DVW++G +MAEL++ PL+PG +E D++ IC+ G PK
Sbjct: 168 PEVLLRSSVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPK------- 220
Query: 243 CKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASR 302
D +QL SS ++ V P+ LK+L
Sbjct: 221 -----------KSDWPEGYQLASSMNFRFPQCV-PIN-----LKTL-------------- 249
Query: 303 LTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSMQQL-------RSA 355
P+ ++L+ ML W+ +R + S AL+HP+ + Q+ +
Sbjct: 250 --IPNAS--------NEAIQLMTEMLNWDPKKRPTASQALKHPYFQVGQVLGPSSNHLES 299
Query: 356 HETTHYYQLSLRSYRLSLQVEGKPPTPVVAAEDGTP 391
++ + L S ++VE KP ++ G P
Sbjct: 300 KQSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQP 335
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,384,776
Number of Sequences: 37866
Number of extensions: 1306511
Number of successful extensions: 5773
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 440
Number of HSP's successfully gapped in prelim test: 325
Number of HSP's that attempted gapping in prelim test: 3791
Number of HSP's gapped (non-prelim): 1088
length of query: 616
length of database: 18,247,518
effective HSP length: 108
effective length of query: 508
effective length of database: 14,157,990
effective search space: 7192258920
effective search space used: 7192258920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.