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Search of human proteins with 31083193
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|31083193 adenylate cyclase 1 [Homo sapiens]
(1119 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|31083193 adenylate cyclase 1 [Homo sapiens] 2234 0.0
gi|34486092 adenylate cyclase 5 [Homo sapiens] 753 0.0
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 728 0.0
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 727 0.0
gi|4557257 adenylate cyclase 8 [Homo sapiens] 660 0.0
gi|115387102 adenylate cyclase 2 [Homo sapiens] 604 e-172
gi|24497587 adenylate cyclase 4 [Homo sapiens] 594 e-169
gi|4557255 adenylate cyclase 7 [Homo sapiens] 592 e-169
gi|148536830 adenylate cyclase 3 [Homo sapiens] 556 e-158
gi|50959205 adenylate cyclase 9 [Homo sapiens] 211 4e-54
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 117 5e-26
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 117 5e-26
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 117 5e-26
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 117 5e-26
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 117 5e-26
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 117 6e-26
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 117 6e-26
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 115 2e-25
gi|134152694 guanylate cyclase 2F [Homo sapiens] 115 3e-25
gi|222080083 guanylate cyclase 2C [Homo sapiens] 111 3e-24
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 111 3e-24
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 111 4e-24
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 110 7e-24
gi|5032007 purine-rich element binding protein A [Homo sapiens] 38 0.061
gi|21322252 androgen receptor isoform 1 [Homo sapiens] 37 0.080
gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo sa... 37 0.14
gi|122937424 one cut homeobox 3 [Homo sapiens] 37 0.14
gi|31542255 hypothetical protein LOC140706 [Homo sapiens] 36 0.23
gi|50843837 hypothetical protein LOC55701 [Homo sapiens] 36 0.23
gi|238859557 regulatory factor X1 [Homo sapiens] 35 0.30
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 2234 bits (5789), Expect = 0.0
Identities = 1119/1119 (100%), Positives = 1119/1119 (100%)
Query: 1 MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAA 60
MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAA
Sbjct: 1 MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAA 60
Query: 61 TLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQ 120
TLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQ
Sbjct: 61 TLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQ 120
Query: 121 QVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVR 180
QVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVR
Sbjct: 121 QVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVR 180
Query: 181 SLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQR 240
SLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQR
Sbjct: 181 SLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQR 240
Query: 241 KAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHD 300
KAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHD
Sbjct: 241 KAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHD 300
Query: 301 NVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL 360
NVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL
Sbjct: 301 NVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL 360
Query: 361 TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS 420
TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS
Sbjct: 361 TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS 420
Query: 421 NDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSH 480
NDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSH
Sbjct: 421 NDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSH 480
Query: 481 RRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALR 540
RRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALR
Sbjct: 481 RRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALR 540
Query: 541 TASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQK 600
TASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQK
Sbjct: 541 TASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQK 600
Query: 601 YHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRV 660
YHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRV
Sbjct: 601 YHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRV 660
Query: 661 QCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALP 720
QCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALP
Sbjct: 661 QCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALP 720
Query: 721 TLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAV 780
TLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAV
Sbjct: 721 TLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAV 780
Query: 781 SGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNL 840
SGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNL
Sbjct: 781 SGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNL 840
Query: 841 LPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEI 900
LPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEI
Sbjct: 841 LPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEI 900
Query: 901 IADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFD 960
IADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFD
Sbjct: 901 IADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFD 960
Query: 961 VLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQV 1020
VLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQV
Sbjct: 961 VLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQV 1020
Query: 1021 TEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRA 1080
TEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRA
Sbjct: 1021 TEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRA 1080
Query: 1081 GLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA 1119
GLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA
Sbjct: 1081 GLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA 1119
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 753 bits (1944), Expect = 0.0
Identities = 463/1121 (41%), Positives = 640/1121 (57%), Gaps = 105/1121 (9%)
Query: 2 AGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRAC---------DEEFACPELEALFRGY 52
AGA GG G G G G + AG L AC ++F +LE L++ Y
Sbjct: 175 AGAVEGGEGSGDG-GSSADSGSGAGPGAVLSLGACCLALLQIFRSKKFPSDKLERLYQRY 233
Query: 53 TLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVR 112
RL Q++ +AVL L+ + P P LA + V +L +A+L
Sbjct: 234 FFRLNQSSLTMLMAVLVLVCLVMLAFHAARPPLQLPYLAVLAAAVGVILIMAVLCNRAAF 293
Query: 113 SLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFV 172
L +A++ ++ L P P +A +G+W + +
Sbjct: 294 HQDHMGLACYALIAVVLAVQVVGLLLP---------------QPRSASEGIWWTVFFIYT 338
Query: 173 SYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVR 232
Y LLPVR A+ G++++A HL + A A+ L + L +N L+F N+ GV
Sbjct: 339 IYTLLPVRMRAAVLSGVLLSALHLAI-ALRTNAQDQFLLKQLVSNVLIFSCTNIVGVCTH 397
Query: 233 ILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF-LKPPERIF 291
E SQR+AF + R CI+ RL + EN++QERLL+S+LPR+VAMEMK D K + +F
Sbjct: 398 YPAEVSQRQAFQETRECIQARLHSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMF 457
Query: 292 HKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILG 351
HKIYIQ+HDNVSILFADI GFT LASQCTAQELV LNELF +FD+LA ENHC RIKILG
Sbjct: 458 HKIYIQKHDNVSILFADIEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILG 517
Query: 352 DCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGL 411
DCYYCVSGL + + DHAHCCVEMG+DMI+ I+ V E T V++NMRVG+H+GRV CGVLGL
Sbjct: 518 DCYYCVSGLPEARADHAHCCVEMGMDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGL 577
Query: 412 RKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNI 471
RKWQ+DVWSNDVTLAN MEA G G++HITK TL LNGDYEVEPG G ERN++LK H+I
Sbjct: 578 RKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSI 637
Query: 472 ETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVM--- 528
ETF I+ +++ K K M K + H + AE PF N +
Sbjct: 638 ETFLILRCTQKR----------KEEKAMIAKMNRQRTNSIGHNPPHWGAERPFYNHLGGN 687
Query: 529 TCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTE-LEMADLNF 587
+ KR +K S+ P V+ ++ R ++AR + L +
Sbjct: 688 QVSKEMKRMGFEDPKDKNAQESA--------NPEDEVDEFLGRAIDARSIDRLRSEHVRK 739
Query: 588 FTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICF 647
F L ++ + E+KY + D+ F + V ++ V + I P S+ +L + C
Sbjct: 740 FLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVPHSIFMLSFYLTC-SL 798
Query: 648 LVACVLYLHI--TRVQCFPGCLTIQIR---------TVLCIFIVVLIYSVA--------Q 688
L+ V+++ + + V+ FP L R T++ +F + L++ A
Sbjct: 799 LLTLVVFVSVIYSCVKLFPSPLQTLSRKIVRSKMNSTLVGVFTITLVFLAAFVNMFTCNS 858
Query: 689 GCVVGCLPWAW---SSKPNS-----SLVVLSSGGQR--TALPTLPCESTHHALLCCLVGT 738
++GCL +S+ N+ S V S G ++ P C + L+
Sbjct: 859 RDLLGCLAQEHNISASQVNACHVAESAVNYSLGDEQGFCGSPWPNCNFPEYFTYSVLLSL 918
Query: 739 LPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAV-----------SGRSYEP 787
L ++F ++S + K++L+ + Y+L++E+ G T + +G S P
Sbjct: 919 LACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNADLLVTANAIDFFNNGTSQCP 978
Query: 788 ------------IVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRR 835
+ I +F AL LHA+QV+ RLD+LW QA EE+E+ME+++ NRR
Sbjct: 979 EHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRR 1038
Query: 836 ILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLR 895
+L N+LP VA HFL RN +LYYQS V VMFASI NF++FY+EL+ NN GVECLR
Sbjct: 1039 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR 1098
Query: 896 LLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFA 955
LLNEIIADFDE++ +D ++ +EKIKTIGSTYMAA GL ++ K K +H+ LADFA
Sbjct: 1099 LLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGK---THIKALADFA 1155
Query: 956 IEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQ 1015
+++ D + IN S+N+F +++G+N+GPVVAGVIGAR+PQYDIWGNTVNVASRMDSTGV
Sbjct: 1156 MKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVP 1215
Query: 1016 GRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEG 1056
RIQVT +++++L Y CRG V VKGKGEM+TYFL G
Sbjct: 1216 DRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNG 1256
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 728 bits (1880), Expect = 0.0
Identities = 449/1103 (40%), Positives = 629/1103 (57%), Gaps = 96/1103 (8%)
Query: 11 GGGGAGEPGGAERAAGTSRRRGLRACD-EEFACPELEALFRGYTLRLEQAATLKALAVLS 69
GG P R+ + RR ++ ++F +LE L++ Y ++ Q++ +AVL
Sbjct: 101 GGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLV 160
Query: 70 LLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLF 129
LL L LA P P LF+ L+VV N S + + V + L
Sbjct: 161 LLTAVL-LAFHAAPARPQPAYV-ALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLG- 217
Query: 130 SLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGL 189
+ +GG A P + G+W + +++Y LLP+R A+ GL
Sbjct: 218 ------ILAAVQVGG------ALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGL 265
Query: 190 VVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSC 249
++ HL++ L LW+ LGAN LLF+ N+ G+ E SQR+AF + R
Sbjct: 266 GLSTLHLILAWQLNRGDA-FLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGY 324
Query: 250 IEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF-LKPPERIFHKIYIQRHDNVSILFAD 308
I+ RL L+ EN +QERLL+S+LP++VAMEMKED K + +FHKIYIQ+HDNVSILFAD
Sbjct: 325 IQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFAD 384
Query: 309 IVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHA 368
I GFT LASQCTAQELV LNELF +FD+LA ENHC RIKILGDCYYCVSGL + + DHA
Sbjct: 385 IEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHA 444
Query: 369 HCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANV 428
HCCVEMG+DMI+ I+ V E T V++NMRVG+H+GRV CGVLGLRKWQ+DVWSNDVTLAN
Sbjct: 445 HCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANH 504
Query: 429 MEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRKIFPGL 488
MEA G G++HIT+ TL LNGDYEVEPG G ERN++LK +IETF I+ + +++
Sbjct: 505 MEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKA 564
Query: 489 ILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRN 548
+L+ ++ + + + +P +D R + N
Sbjct: 565 MLAKLQRTRANSMEG-------------LMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDN 611
Query: 549 RSSFSTNVVYTTPGTRVNRYISRLLEARQTE-LEMADLNFFTLKYKHVEREQKYHQLQDE 607
R + P V+ ++SR ++AR + L + F L ++ + E+KY + D
Sbjct: 612 RGTQDA----LNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDP 667
Query: 608 YFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQC---FP 664
F + V L++ + LLIFP S L+L ++ FL+ + L C FP
Sbjct: 668 RFGAYVACALLVFCFICFIQLLIFPHS--TLMLGIYASIFLLLLITVLICAVYSCGSLFP 725
Query: 665 GCLTIQIR---------TVLCIFIVVLIYSVA------------QGCVVGCLPWAWSSKP 703
L R T + IF V+L+++ A + C L +
Sbjct: 726 KALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMFTCNHTPIRSCAARMLNLTPADIT 785
Query: 704 NSSLVVLS-SGGQRTAL--PTLP-CESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGL 759
L L+ S G L T+P C + + L+ L ++F +SS+ K+ ++ L
Sbjct: 786 ACHLQQLNYSLGLDAPLCEGTMPTCSFPEYFIGNMLLSLLASSVFLHISSIGKLAMIFVL 845
Query: 760 TTSYILVLEL--------------------------SGYTRTGGGAVSGRSYEPIVAILL 793
Y+++L L G G V+ + P++ +L+
Sbjct: 846 GLIYLVLLLLGPPATIFDNYDLLLGVHGLASSNETFDGLDCPAAGRVALKYMTPVI-LLV 904
Query: 794 FSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSN 853
F+ AL LHA+QV+ RLD+LW QA E+E+ME+++ NRR+L N+LP VA HFL
Sbjct: 905 FALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRRLLHNILPKDVAAHFLARE 964
Query: 854 PRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFY 913
RN +LYYQS V VMFASI NF++FY+EL+ NN GVECLRLLNEIIADFDE++ ++ +
Sbjct: 965 RRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLRLLNEIIADFDEIISEERF 1024
Query: 914 KDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDF 973
+ +EKIKTIGSTYMAA GL ++ + + SH++ LAD+A+ + + + IN S+N+F
Sbjct: 1025 RQLEKIKTIGSTYMAASGLNASTYDQVGR---SHITALADYAMRLMEQMKHINEHSFNNF 1081
Query: 974 VLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPY 1033
+++G+N+GPVVAGVIGAR+PQYDIWGNTVNV+SRMDSTGV RIQVT +++++L Y
Sbjct: 1082 QMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVPDRIQVTTDLYQVLAAKGY 1141
Query: 1034 HFVCRGKVSVKGKGEMLTYFLEG 1056
CRG V VKGKGEM TYFL G
Sbjct: 1142 QLECRGVVKVKGKGEMTTYFLNG 1164
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 727 bits (1877), Expect = 0.0
Identities = 444/1061 (41%), Positives = 620/1061 (58%), Gaps = 65/1061 (6%)
Query: 11 GGGGAGEPGGAERAAGTSRRRGLRACD-EEFACPELEALFRGYTLRLEQAATLKALAVLS 69
GG P R+ + RR ++ ++F +LE L++ Y ++ Q++ +AVL
Sbjct: 101 GGTAEVAPDAVPRSGRSCWRRLVQVFQSKQFRSAKLERLYQRYFFQMNQSSLTLLMAVLV 160
Query: 70 LLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLF 129
LL L LA P P LF+ L+VV N S + + V + L
Sbjct: 161 LLTAVL-LAFHAAPARPQPAYV-ALLACAAALFVGLMVVCNRHSFRQDSMWVVSYVVLG- 217
Query: 130 SLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGL 189
+ +GG A P + G+W + +++Y LLP+R A+ GL
Sbjct: 218 ------ILAAVQVGG------ALAADPRSPSAGLWCPVFFVYIAYTLLPIRMRAAVLSGL 265
Query: 190 VVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSC 249
++ HL++ L LW+ LGAN LLF+ N+ G+ E SQR+AF + R
Sbjct: 266 GLSTLHLILAWQLNRGDA-FLWKQLGANVLLFLCTNVIGICTHYPAEVSQRQAFQETRGY 324
Query: 250 IEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDF-LKPPERIFHKIYIQRHDNVSILFAD 308
I+ RL L+ EN +QERLL+S+LP++VAMEMKED K + +FHKIYIQ+HDNVSILFAD
Sbjct: 325 IQARLHLQHENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFAD 384
Query: 309 IVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHA 368
I GFT LASQCTAQELV LNELF +FD+LA ENHC RIKILGDCYYCVSGL + + DHA
Sbjct: 385 IEGFTSLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHA 444
Query: 369 HCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANV 428
HCCVEMG+DMI+ I+ V E T V++NMRVG+H+GRV CGVLGLRKWQ+DVWSNDVTLAN
Sbjct: 445 HCCVEMGVDMIEAISLVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANH 504
Query: 429 MEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSHRRKIFPGL 488
MEA G G++HIT+ TL LNGDYEVEPG G ERN++LK +IETF I+ + +++
Sbjct: 505 MEAGGRAGRIHITRATLQYLNGDYEVEPGRGGERNAYLKEQHIETFLILGASQKRKEEKA 564
Query: 489 ILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRN 548
+L+ ++ + + + +P +D R + N
Sbjct: 565 MLAKLQRTRANSMEG-------------LMPRWVPDRAFSRTKDSKAFRQMGIDDSSKDN 611
Query: 549 RSSFSTNVVYTTPGTRVNRYISRLLEARQTE-LEMADLNFFTLKYKHVEREQKYHQLQDE 607
R + P V+ ++SR ++AR + L + F L ++ + E+KY + D
Sbjct: 612 RGTQDA----LNPEDEVDEFLSRAIDARSIDQLRKDHVRRFLLTFQREDLEKKYSRKVDP 667
Query: 608 YFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQC---FP 664
F + V L++ + LLIFP S L+L ++ FL+ + L C FP
Sbjct: 668 RFGAYVACALLVFCFICFIQLLIFPHST--LMLGIYASIFLLLLITVLICAVYSCGSLFP 725
Query: 665 GCLTIQIR---------TVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQ 715
L R T + IF V+L+++ A + S +S + +SS G+
Sbjct: 726 KALQRLSRSIVRSRAHSTAVGIFSVLLVFTSAIANMYFIGNMLLSLLASSVFLHISSIGK 785
Query: 716 RTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRT 775
+ L L+ L+G P IF + ++ + GL +S G
Sbjct: 786 LAMIFVLGLIY----LVLLLLGP-PATIF---DNYDLLLGVHGLASSNET---FDGLDCP 834
Query: 776 GGGAVSGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRR 835
G V+ + P++ +L+F+ AL LHA+QV+ RLD+LW QA E+E+ME+++ NRR
Sbjct: 835 AAGRVALKYMTPVI-LLVFALALYLHAQQVESTARLDFLWKLQATGEKEEMEELQAYNRR 893
Query: 836 ILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLR 895
+L N+LP VA HFL RN +LYYQS V VMFASI NF++FY+EL+ NN GVECLR
Sbjct: 894 LLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECLR 953
Query: 896 LLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFA 955
LLNEIIADFDE++ ++ ++ +EKIKTIGSTYMAA GL ++ + + SH++ LAD+A
Sbjct: 954 LLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGR---SHITALADYA 1010
Query: 956 IEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQ 1015
+ + + + IN S+N+F +++G+N+GPVVAGVIGAR+PQYDIWGNTVNV+SRMDSTGV
Sbjct: 1011 MRLMEQMKHINEHSFNNFQMKIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVP 1070
Query: 1016 GRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEG 1056
RIQVT +++++L Y CRG V VKGKGEM TYFL G
Sbjct: 1071 DRIQVTTDLYQVLAAKGYQLECRGVVKVKGKGEMTTYFLNG 1111
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 660 bits (1703), Expect = 0.0
Identities = 427/1102 (38%), Positives = 610/1102 (55%), Gaps = 87/1102 (7%)
Query: 7 GGGGGGGGAGEPGGAERAAGTSRR----------RGL--RACDEEFACPELEALFRGYTL 54
G G GG G+ G S RG+ F +LE L++ Y L
Sbjct: 116 GSASGSGGGGDLGFLHLDCAPSNSDFFLNGGYSYRGVIFPTLRNSFKSRDLERLYQRYFL 175
Query: 55 --RLEQAATLKALAVLSLLAGALALAELLGAP-GPAPGLAKGSHPVHCVLFLALLVVTNV 111
R + + L VL+ L + L AP P G+ G V+ AL+VV
Sbjct: 176 GQRRKSEVVMNVLDVLTKLTLLVLHLSLASAPMDPLKGILLGFFTGIEVVICALVVVRKD 235
Query: 112 RSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTF 171
+ LQ G + T+ + G G G G+ +L F
Sbjct: 236 TTSHT-YLQYSGVV------TWVAMTTQILAAGLGYGLLG---------DGIGYVLFTLF 279
Query: 172 VSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFV 231
+Y++LP+ AI GL + +++ ++P + A A+LF+ +N G+F+
Sbjct: 280 ATYSMLPLPLTWAILAGLGTSLLQVILQV-VIPRLAVISINQVVAQAVLFMCMNTAGIFI 338
Query: 232 RILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERI- 290
L++R+QR+AFL+ R C+E RLRLE EN++QERL++S+LPR V +EM D +
Sbjct: 339 SYLSDRAQRQAFLETRRCVEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHL 398
Query: 291 ---FHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRI 347
FH+IYI R++NVSILFAD+ GFT L++ +AQELV++LNELF +FD LA E+HC RI
Sbjct: 399 QHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRI 458
Query: 348 KILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCG 407
KILGDCYYCVSGL +P+ DHAHCCVEMGL MI TI V T+ D++MR+G+H+G VLCG
Sbjct: 459 KILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDVDMRIGIHSGSVLCG 518
Query: 408 VLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLK 467
VLGLRKWQ+DVWS DV +AN +E+ G+PG++HI+K TL CLNGDY VE G+G ERN FL+
Sbjct: 519 VLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLR 578
Query: 468 THNIETFFI-VPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSN 526
HNIET+ I P P I+ + + + + + E+PF N
Sbjct: 579 KHNIETYLIKQPEDSLLSLPEDIVKESVSSSDRRNSGATF-------TEGSWSPELPFDN 631
Query: 527 VMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQ-TELEMADL 585
++ + + R + L N + + +V + +N+ I ++ R +L +
Sbjct: 632 IVG-KQNTLAALTRNSINLLPNHLAQALHV--QSGPEEINKRIEHTIDLRSGDKLRREHI 688
Query: 586 NFFTLKYKHVEREQKYHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCI 645
F+L +K E KY Q++DE F S +V I+ LF + P S V+ + + F I
Sbjct: 689 KPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIV-LLFITAIQSLLPSSRVMPMTIQFSI 747
Query: 646 CFLVACVLYLHITRVQCFPGCLTIQIRTVLC------------IFIVVLIYSVAQGCVVG 693
++ L L IT + + CL + +R C IF +LI + G ++
Sbjct: 748 LIMLHSALVL-ITTAEDYK-CLPLILRKTCCWINETYLARNVIIFASILINFL--GAILN 803
Query: 694 CLPWAWSSK--PNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLP 751
L W K P +L SS A+ T C + + ++ + A+F R++S+
Sbjct: 804 IL-WCDFDKSIPLKNLTFNSS-----AVFTDICSYPEYFVFTGVLAMVTCAVFLRLNSVL 857
Query: 752 KMILLSGLTTSYILVLEL--------SGYTRTGGGAVSGRSYEPIVAILLFSCALALHAR 803
K+ +L + Y L+ E G G ++ + +F A+ H +
Sbjct: 858 KLAVLLIMIAIYALLTETVYAGLFLRYDNLNHSGEDFLGTKEVSLLLMAMFLLAVFYHGQ 917
Query: 804 QVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQS 863
Q++ RLD+LW QA+EE +M++++ N +L N+LP+HVA+HFL + N +LY QS
Sbjct: 918 QLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQS 977
Query: 864 YSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIG 923
Y VGVMFASIP F DFY + + NN GVECLRLLNEIIADFDEL+ +D ++DIEKIKTIG
Sbjct: 978 YDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIG 1037
Query: 924 STYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGP 983
STYMA GL+P K HL LADF++ + + + EIN S+N+F LR+GI+ G
Sbjct: 1038 STYMAVSGLSPEKQQCEDK--WGHLCALADFSLALTESIQEINKHSFNNFELRIGISHGS 1095
Query: 984 VVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSV 1043
VVAGVIGA++PQYDIWG TVN+ASRMDSTGV GRIQV EE + +L+ + F RG++ V
Sbjct: 1096 VVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIYV 1155
Query: 1044 KG----KGEMLTYFLEGRTDGN 1061
KG +G++ TYFL GR N
Sbjct: 1156 KGISEQEGKIKTYFLLGRVQPN 1177
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 604 bits (1558), Expect = e-172
Identities = 388/1045 (37%), Positives = 572/1045 (54%), Gaps = 117/1045 (11%)
Query: 96 PVHCVLFLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGG 155
P +F A+ ++ + S+ +L LFSL + C A+G GG
Sbjct: 83 PTALAIFFAIFILVCIESV-------FKKLLRLFSLVIWI--CLVAMGYLFM----CFGG 129
Query: 156 PATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPA----KRPRLW 211
+ V L + FV Y +LP AI ++ ++SH +V + + A K +W
Sbjct: 130 TVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVW 189
Query: 212 RTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLL 271
+ L AN ++F+ N+ G + + L E + ++ + +CI+ R++LE E +QERLL+SLL
Sbjct: 190 QIL-ANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLL 248
Query: 272 PRNVAMEMKEDFLKPPE----------RIFHKIYIQRHDNVSILFADIVGFTGLASQCTA 321
P ++AMEMK + ++ + FH +Y++RH NVSIL+ADIVGFT LAS C+
Sbjct: 249 PAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSP 308
Query: 322 QELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDT 381
ELV +LNELFGKFD++A EN C RIKILGDCYYCVSGL +HA CV+MGLDM +
Sbjct: 309 GELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEA 368
Query: 382 ITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHIT 441
I V +AT VD+NMRVG+H+G VLCGV+GL+KWQYDVWS+DVTLAN MEA G+PG+VHI+
Sbjct: 369 IKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHIS 428
Query: 442 KTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIV--------PSH----RRKIFPGLI 489
TL LNG Y+VE G G R+ +LK H ++T+F++ P H R + +
Sbjct: 429 SVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKM 488
Query: 490 LSDIKPAKRMKFKTVCYLLVQLMHCRKMF--KAEIPFSNVMTCEDDDKRRALRTASEKLR 547
+ ++ + ++ L H M +I ++V + + + R LRT S+K R
Sbjct: 489 RASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKR 548
Query: 548 NRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDE 607
+ ++ G + A++ L+ D+ +L + + E++Y
Sbjct: 549 FEEELNERMIQAIDG----------INAQKQWLKSEDIQRISLLFYNKVLEKEYRATALP 598
Query: 608 YFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICF-LVACVLYLHITRVQCFPGC 666
F V ++ +V +L+ P++ V L + F F L+A +L++ CF G
Sbjct: 599 AFKYYVTCACLIFFCIFIVQILVLPKTSV--LGISFGAAFLLLAFILFV------CFAGQ 650
Query: 667 LTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLS--------------- 711
L +Q ++ L+ S ++ PW P SL +++
Sbjct: 651 L-LQCSKKASPLLMWLLKSSG---IIANRPW-----PRISLTIITTAIILMMAVFNMFFL 701
Query: 712 SGGQRTALPTLPCESTH--------------------HALLCCLVGTLPLAIFFRVSSLP 751
S + T PT +T + + C++G + ++F RV+
Sbjct: 702 SDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYEL 761
Query: 752 KMILLSGLTTSYILVL------ELSGYTRT---GGGAVSGRSYEPIVAILLFSCALALHA 802
KM+++ Y +L L Y++ G V++ +F L +
Sbjct: 762 KMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLG 821
Query: 803 RQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQ 862
RQ + RLD+LW + ++ERE++E ++ NR +L N+LPAHVA+HFL + +N +LY+Q
Sbjct: 822 RQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQ 881
Query: 863 SYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTI 922
SY V VMFASIP+F +FY E D N G+ECLRLLNEIIADFD+L+ K + +EKIKTI
Sbjct: 882 SYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTI 941
Query: 923 GSTYMAAVGLAPTSGTKAKKSIS---SHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGI 979
GSTYMAA GL+ + + H+ T+ +FA + LD IN S+NDF LRVGI
Sbjct: 942 GSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGI 1001
Query: 980 NVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRG 1039
N GPV+AGVIGA++PQYDIWGNTVNVASRMDSTGV +IQVTEE +L+ Y CRG
Sbjct: 1002 NHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRG 1061
Query: 1040 KVSVKGKGEMLTYFLEGRTDGNGSQ 1064
++VKGKG++ TYF+ + SQ
Sbjct: 1062 IINVKGKGDLKTYFVNTEMSRSLSQ 1086
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 594 bits (1531), Expect = e-169
Identities = 392/980 (40%), Positives = 545/980 (55%), Gaps = 77/980 (7%)
Query: 154 GGPATAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLV---PAKRPRL 210
GG +A V L V F +YA+LP+ A GL + SHLLV + P RP L
Sbjct: 111 GGVVSAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPAL 170
Query: 211 WRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSL 270
L ANA+LF+ N+ GV+ + L ER+ R F +A S + R RL+ E + QE LL+S+
Sbjct: 171 LPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSI 230
Query: 271 LPRNVAMEMKEDFL--------KPPERI--FHKIYIQRHDNVSILFADIVGFTGLASQCT 320
LP +A EMK + + PE FH +Y++RH VS+L+ADIVGFT LAS+C+
Sbjct: 231 LPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECS 290
Query: 321 AQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMID 380
+ELV +LNELFGKFD++A E+ C RIKILGDCYYCVSGL DHA CV MGLDM
Sbjct: 291 PKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCR 350
Query: 381 TITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHI 440
I + AT VD+NMRVG+H+G VLCGV+GL+KWQYDVWS+DVTLAN MEA G+PG+VHI
Sbjct: 351 AIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHI 410
Query: 441 TKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIV----PSHRRKIFPGLILSDIKPA 496
T TLA L G Y VE R+ +L+ T+ ++ K G +LS ++
Sbjct: 411 TGATLALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGL 470
Query: 497 KRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKL---RNRSSFS 553
K M+ + ++ K F + ++ + L + S + R+R+
Sbjct: 471 K-MRPSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRG 529
Query: 554 TNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAV 613
+ T + + I +L +Q + + D N TL ++ E E++Y F
Sbjct: 530 LDDELDTGDAKFFQVIEQLNSQKQWK-QSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYE 588
Query: 614 VLTLILAALFGLVYLLIF--PQSVVV-------LLLLVFCICF---LVACVL----YLH- 656
T ++ ++ +L+ P ++ + L LL+ +CF L+ CVL LH
Sbjct: 589 ACTFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHW 648
Query: 657 ----ITRVQCFPGC-LTIQIRTVLCIFIVVL----IYSVAQGCVVGCLPWAWSSKPNSSL 707
V PG + + T+L +F + + + + C PN S
Sbjct: 649 LPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPF--------QAPNVSS 700
Query: 708 VVLSSGGQRTALP-TLPCESTHHALLCCLVGTLPLAIFFRVS-SLPKMILLSGLTTSYIL 765
++ + + LP +LP S +++ CC +G L ++F +S L ++LL L S L
Sbjct: 701 MISNLSWE---LPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSL 757
Query: 766 VLELSGY------TRTGGGAVSGRS---YEP----IVAILLFSCALALHARQVDIRLRLD 812
L + R G + R EP ++ +F L + ARQ + RLD
Sbjct: 758 FLHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLD 817
Query: 813 YLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFA 872
+LW + +ERE+ E ++ R +L N+LPAHVA F+ N RN DLY+QSY V V+FA
Sbjct: 818 FLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFA 877
Query: 873 SIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGL 932
S+P+F +FY E + N+ G+ECLRLLNEIIADFDEL+ K + +EKIKTIGSTYMAA GL
Sbjct: 878 SVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGL 937
Query: 933 APTSGTKAKKSIS---SHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVI 989
TSG A++ SHL T+ +FA+ + LD IN S+N+F LRVG+N GPVVAGVI
Sbjct: 938 NATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVI 997
Query: 990 GARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGEM 1049
GA++PQYDIWGNTVNVASRM+STGV G+IQVTEE L+ Y RG + VKGKG++
Sbjct: 998 GAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQL 1057
Query: 1050 LTYFLEGRTDGNGSQIRSLG 1069
TYFL G +LG
Sbjct: 1058 CTYFLNTDLTRTGPPSATLG 1077
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 592 bits (1526), Expect = e-169
Identities = 411/1086 (37%), Positives = 587/1086 (54%), Gaps = 108/1086 (9%)
Query: 43 PELEALFRGYTLRLEQAATLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVH-CVL 101
P+ +AL+ Y L + L L LL A A L+ ++G H +L
Sbjct: 16 PDQDALYEKYQLTSQHGPLLLTL----LLVAATACVALI-----IIAFSQGDPSRHQAIL 66
Query: 102 FLALLVVTNVRSLQVPQLQQVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQ 161
+A LV+ +L V + L +L C ALG A A A +
Sbjct: 67 GMAFLVLAVFAALSVLMYVECLLRRWLRALALLTWACLVALGYVLVFDAWTKA--ACAWE 124
Query: 162 GVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLV---PAKRPRLWRTLGANA 218
V L + FV Y LLP A+ G V ASHLLV +L+ R+ L ANA
Sbjct: 125 QVPFFLFIVFVVYTLLPFSMRGAVAVGAVSTASHLLVLGSLMGGFTTPSVRVGLQLLANA 184
Query: 219 LLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAME 278
++F+ N+ G F + + + R F CI+ R +L E +QE LL+S+LP +++M
Sbjct: 185 VIFLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRRKLRIEKRQQENLLLSVLPAHISMG 244
Query: 279 MKEDFLKP----------PERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLL 328
MK ++ P+ FH +Y++RH NVSIL+ADIVGFT LAS C+ +ELV +L
Sbjct: 245 MKLAIIERLKEHGDRRCMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKELVVVL 304
Query: 329 NELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEA 388
NELFGKFD++A N C RIKILGDCYYCVSGL HA CV+MGLDM I V EA
Sbjct: 305 NELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDMCQAIKQVREA 364
Query: 389 TEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACL 448
T VD+NMRVG+H+G VLCGV+GLRKWQYDVWS+DV+LAN MEAAG+PG+VHIT+ TL L
Sbjct: 365 TGVDINMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEATLKHL 424
Query: 449 NGDYEVEPGYGHERNSFLKTHNIETFFIV-PSHRRKIFPGLILSDIKPAKRMKFKTVCYL 507
+ YEVE G+G +R+ +LK NI T+ ++ P ++ P L K +K +
Sbjct: 425 DKAYEVEDGHGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPRPKGDAALKMRA---- 480
Query: 508 LVQLMHCRKMFKAEIPFSNV-----MTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPG 562
V++ + + A PF+++ ++ + R S R+R + ++ +P
Sbjct: 481 SVRMTRYLESWGAARPFAHLNHRESVSSGETHVPNGRRPKSVPQRHRRTPDRSM---SPK 537
Query: 563 TRV--NRYISRLLEARQTELEMADL-----NFFTLKYKHVER--EQKYH-----QLQDEY 608
R + Y +L A + +F+T +E+ E++Y + + ++
Sbjct: 538 GRSEDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGSIFLEKGFEREYRLAPIPRARHDF 597
Query: 609 FTSAVVLTLILAALFGLVYLLIFPQS---------VVVLLLLVFCICFLV----AC---- 651
++++ IL LV++L+ P++ V +L LV +CF C
Sbjct: 598 ACASLIFVCIL-----LVHVLLMPRTAALGVSFGLVACVLGLVLGLCFATKFSRCCPARG 652
Query: 652 VLYLHITRVQCFPGC-LTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVL 710
L RV+ P LT+ + T+ + V +I V LP + +L
Sbjct: 653 TLCTISERVETQPLLRLTLAVLTIGSLLTVAIINLPLMPFQVPELP------VGNETGLL 706
Query: 711 SSGGQRTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELS 770
++ + AL CE + C++G + ++F R+S PK++LL+ +Y+++ LS
Sbjct: 707 AASSKTRAL----CEPLPYYTCSCVLGFIACSVFLRMSLEPKVVLLTVALVAYLVLFNLS 762
Query: 771 ------------GYTRTGGGAVSGR---SYEPIVA-----ILLFSCALALHARQVDIRLR 810
G G SG S++ + ++LF L +RQ+D R
Sbjct: 763 PCWQWDCCGQGLGNLTKPNGTTSGTPSCSWKDLKTMTNFYLVLFYITLLTLSRQIDYYCR 822
Query: 811 LDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVM 870
LD LW + ++E E+ E ++ NR +L N+LPAHVA HF+ + N D Y+QSY V VM
Sbjct: 823 LDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAHFI-GDKLNEDWYHQSYDCVCVM 881
Query: 871 FASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAV 930
FAS+P+F FY E D N G+ECLRLLNEIIADFDEL+ K + +EKIKTIGSTYMAA
Sbjct: 882 FASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAA 941
Query: 931 GLAPTSG--TKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGV 988
GL+ SG + + +H+ + +F+I + LD IN S+N F LRVGIN GPV+AGV
Sbjct: 942 GLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGV 1001
Query: 989 IGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVCRGKVSVKGKGE 1048
IGAR+PQYDIWGNTVNVASRM+STG G+IQVTEE +L+ Y CRG ++VKGKGE
Sbjct: 1002 IGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQGLGYSCECRGLINVKGKGE 1061
Query: 1049 MLTYFL 1054
+ TYF+
Sbjct: 1062 LRTYFV 1067
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 556 bits (1432), Expect = e-158
Identities = 353/980 (36%), Positives = 533/980 (54%), Gaps = 114/980 (11%)
Query: 164 WQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTATLVPAKRP------RLWRTLGAN 217
WQ+ V F + LP+ + +V H LV V ++ +L R + AN
Sbjct: 171 WQVFFV-FSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILAN 229
Query: 218 ALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAM 277
L++ G+ + +R RKAFL+AR +E ++ LE+++++QE L++S+LP++VA
Sbjct: 230 VFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVAD 289
Query: 278 EMKEDFLKPP----ERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFG 333
EM +D K ++ F+ +Y+ RH+NVSILFADIVGFT L+S C+AQELVKLLNELF
Sbjct: 290 EMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFA 349
Query: 334 KFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDL 393
+FD+LA + H RIKILGDCYYC+ GL + DHA C + MGL M++ I+ V E T+ +
Sbjct: 350 RFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGV 409
Query: 394 NMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYE 453
+MRVG+HTG VL GVLG ++WQYDVWS DVT+AN MEA G+PG+VHI+++T+ CL G+++
Sbjct: 410 DMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFD 469
Query: 454 VEPGYGHERNSFLKTHNIETFFIVPS----HRRKIFPGLILSDIKPAKRMKFKTVCYLLV 509
VEPG G R +L+ IET+ I+ S + GL S + K+ L+
Sbjct: 470 VEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALI 529
Query: 510 QLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTP--GTRVNR 567
+ T E + + + SEK + + + N + P R+
Sbjct: 530 E------------------TKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQD 571
Query: 568 YISRLLEARQTELEMADL-----------------NFF--TLKYKHVEREQKYHQLQDEY 608
R+++A + E E+ L N F ++++ E E +Y +++
Sbjct: 572 LADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQ 631
Query: 609 FTSAVVLTLILAALFGLVYLLIFPQ--------SVVVLLLLVFCICFLVACVLYLHITRV 660
+A + ++ LV +LI P V +LLL+ IC L A ++
Sbjct: 632 SGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKL 691
Query: 661 QCFPGCL-----TIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQ 715
F + +L IFI+V+ V ++ CL + + P+++ + + G
Sbjct: 692 VAFSTWIDRTRWARNTWAMLAIFILVMANVVD---MLSCL--QYYTGPSNATAGMETEGS 746
Query: 716 RTALPTLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTS------------- 762
P + ++ + L+ T+ L + L M+L++G +
Sbjct: 747 CLENP----KYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEY 802
Query: 763 -----------YILVLELSGYTRTGGGA----VSGRSYEPIVAILLFSCALALHARQVDI 807
+ + ++ G+ G + Y V + L + +R V+
Sbjct: 803 DHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEK 862
Query: 808 RLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQV 867
R +LW + +++E + +++ N ++ N+LP HVA+HFL S R+ +LY Q+Y ++
Sbjct: 863 LARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEI 922
Query: 868 GVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYM 927
GVMFAS+PNF DFY E NN G+ECLR LNEII+DFD L++ ++ I KIKTIGSTYM
Sbjct: 923 GVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYM 982
Query: 928 AAVGLAPTSGT----------KAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRV 977
AA G+ P T K+++ HL+ LADFA+ M D L IN QS+N+F+LR+
Sbjct: 983 AASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRI 1042
Query: 978 GINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCPYHFVC 1037
G+N G V+AGVIGAR+P YDIWGNTVNVASRM+STGV G IQV EE +LR + FV
Sbjct: 1043 GMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVR 1102
Query: 1038 RGKVSVKGKGEMLTYFLEGR 1057
RG + VKGKGE+LT+FL+GR
Sbjct: 1103 RGPIFVKGKGELLTFFLKGR 1122
Score = 92.0 bits (227), Expect = 3e-18
Identities = 73/279 (26%), Positives = 125/279 (44%), Gaps = 38/279 (13%)
Query: 236 ERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIY 295
E+ R FL + + R+ + E L+ ++LP +VA FL +R ++Y
Sbjct: 861 EKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARH----FLGSKKRD-EELY 915
Query: 296 IQRHDNVSILFADIVGFTGLASQCTAQ----ELVKLLNELFGKFDELATENHCR---RIK 348
Q +D + ++FA + F ++ + E ++ LNE+ FD L R +IK
Sbjct: 916 SQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIK 975
Query: 349 ILGDCYYCVSGLT------------------QPKTDHAHCCVEMGLDMIDTITSVAEATE 390
+G Y SG+T + + H + L M DT+T++ +
Sbjct: 976 TIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSF 1035
Query: 391 VDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNG 450
+ +R+G++ G VL GV+G RK YD+W N V +A+ ME+ G+ G + + + T L
Sbjct: 1036 NNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILR- 1094
Query: 451 DYEVEPGYGHERNS--FLK-THNIETFFIVPSHRRKIFP 486
E G+ R F+K + TFF+ + FP
Sbjct: 1095 ----EYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFP 1129
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 211 bits (536), Expect = 4e-54
Identities = 131/375 (34%), Positives = 199/375 (53%), Gaps = 42/375 (11%)
Query: 127 LLFSLTFALLCCPFALGGPARGSAGAAGGPATA--------EQGVWQLLL-VTFVSYALL 177
L+F+LT A F + P G ++ ATA + G + + + V F+ Y ++
Sbjct: 182 LVFALTLA---AQFQVLTPVSGRGDSSNLTATARPTDTCLSQVGSFSMCIEVLFLLYTVM 238
Query: 178 PVRSLLAIGFGLVVAAS------HLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFV 231
+ L++ G+ + H A L L + LL ++ GV +
Sbjct: 239 HLPLYLSLCLGVAYSVLFETFGYHFRDEACFPSPGAGALHWELLSRGLLHGCIHAIGVHL 298
Query: 232 RILTERSQRKAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEM------------ 279
++++ R FL+ I LE E +ER++ S++PR +A ++
Sbjct: 299 FVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADDLMKQGDEESENSV 358
Query: 280 ------------KEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKL 327
K+ ++ F +Q+ + VSILFADIVGFT +++ +A LV L
Sbjct: 359 KRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFTKMSANKSAHALVGL 418
Query: 328 LNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAE 387
LN+LFG+FD L E C +I LGDCYYCV+G +P+ DHA+CC+EMGL MI I +
Sbjct: 419 LNDLFGRFDRLCEETKCEKISTLGDCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQ 478
Query: 388 ATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLAC 447
+ +NMRVG+HTG VLCG+LG+R++++DVWSNDV LAN+ME G+ GKVHI++ T
Sbjct: 479 EKKEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVNLANLMEQLGVAGKVHISEATAKY 538
Query: 448 LNGDYEVEPGYGHER 462
L+ YE+E G ER
Sbjct: 539 LDDRYEMEDGKVIER 553
Score = 204 bits (520), Expect = 3e-52
Identities = 166/516 (32%), Positives = 238/516 (46%), Gaps = 56/516 (10%)
Query: 585 LNFFTLKYKHVEREQKYH-QLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVF 643
+N F+L + E E+ Y Q+E ++ V T L L +F + V L L
Sbjct: 747 INQFSLNFLDQELERSYRTSYQEEVIKNSPVKTFASPTFSSL--LDVFLSTTVFLTLSTT 804
Query: 644 CICFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKP 703
C A + + F L +++ ++ +V C L W P
Sbjct: 805 CFLKYEAATVPPPPAALAVFSAALLLEVLSLAVSIRMVFFLEDVMACTKRLLEWIAGWLP 864
Query: 704 NSSLVVLSSGGQRTALPTLPCES------------------------THHALLCCLVGTL 739
+ G +LP L S H+ C L +
Sbjct: 865 RHCI-----GAILVSLPALAVYSHVTSEYETNIHFPVFTGSAALIAVVHYCNFCQLSSWM 919
Query: 740 PLAIFFRVSSLPKMILL-------SGLTTSYILVLELSGYTRTGGGAVSGRSYEPIVAI- 791
++ V + P ++L S LT+ V S +V P I
Sbjct: 920 RSSLATVVGAGPLLLLYVSLCPDSSVLTSPLDAVQNFSSERNPCNSSVPRDLRRPASLIG 979
Query: 792 ----LLFSCALALH---ARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAH 844
L+F L L R+ ++ RL Y +A+ R ++ ++ +L N++P H
Sbjct: 980 QEVVLVFFLLLLLVWFLNREFEVSYRLHYHGDVEADLHRTKIQSMRDQADWLLRNIIPYH 1039
Query: 845 VAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADF 904
VA+ +S Y +++ GV+FASI NF++FY E G EC R+LNE+I DF
Sbjct: 1040 VAEQLKVSQT-----YSKNHDSGGVIFASIVNFSEFYEE--NYEGGKECYRVLNELIGDF 1092
Query: 905 DELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDE 964
DEL+ K Y IEKIKTIG+TYMAA GL T+ + HL L +FA EM V+D+
Sbjct: 1093 DELLSKPDYSSIEKIKTIGATYMAASGLN-TAQAQDGSHPQEHLQILFEFAKEMMRVVDD 1151
Query: 965 INYQS-YNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEE 1023
N + +F LRVG N GP+ AGVIG + YDIWG+TVN+ASRMD+TGV+ RIQV+EE
Sbjct: 1152 FNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIASRMDTTGVECRIQVSEE 1211
Query: 1024 VHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTD 1059
+R+L + Y F RG V+VKGKG+M TY TD
Sbjct: 1212 SYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTD 1247
Score = 92.4 bits (228), Expect = 2e-18
Identities = 97/449 (21%), Positives = 183/449 (40%), Gaps = 75/449 (16%)
Query: 620 AALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRVQCFPGCLTIQIRTVLCIFI 679
A L +Y + +S +++++ +CFL+ CV + T + + + + +
Sbjct: 126 ACLLWSIYFAVHMRSRLIVMVAP-ALCFLLVCVGFFLFTFTKLYA-----RHYAWTSLAL 179
Query: 680 VVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALPTLPCESTHHALLCCLVGTL 739
+L++++ L +S+L TA PT C S + C+
Sbjct: 180 TLLVFALTLAAQFQVLTPVSGRGDSSNLTA-------TARPTDTCLSQVGSFSMCIE--- 229
Query: 740 PLAIFFRVSSLPKMILLSGLTTSYILVLELSGY--------TRTGGGAVSGRSYEPIVAI 791
L + + V LP + L L +Y ++ E GY G GA+ +E +
Sbjct: 230 VLFLLYTVMHLPLYLSLC-LGVAYSVLFETFGYHFRDEACFPSPGAGALH---WELLSRG 285
Query: 792 LLFSC--ALALHARQVD-IRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQH 848
LL C A+ +H + +R R +L Q+ +D+E K R++ +++P +A
Sbjct: 286 LLHGCIHAIGVHLFVMSQVRSRSTFLKVGQSIMHGKDLEVEKALKERMIHSVMPRIIADD 345
Query: 849 FLM---------------SNPRNMD--------------LYYQSYSQVGVMFASIPNFND 879
+ S+P+N Q +V ++FA I F
Sbjct: 346 LMKQGDEESENSVKRHATSSPKNRKKKSSIQKAPIAFRPFKMQQIEEVSILFADIVGFT- 404
Query: 880 FYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTK 939
++ N + LLN++ FD L E+ EKI T+G Y G
Sbjct: 405 ---KMSANKSAHALVGLLNDLFGRFDRLCEET---KCEKISTLGDCYYCVAG-------- 450
Query: 940 AKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIW 999
+ + H + + M +++ + +RVG++ G V+ G++G RR ++D+W
Sbjct: 451 CPEPRADHAYCCIEMGLGMIKAIEQFCQEKKEMVNMRVGVHTGTVLCGILGMRRFKFDVW 510
Query: 1000 GNTVNVASRMDSTGVQGRIQVTEEVHRLL 1028
N VN+A+ M+ GV G++ ++E + L
Sbjct: 511 SNDVNLANLMEQLGVAGKVHISEATAKYL 539
Score = 80.9 bits (198), Expect = 6e-15
Identities = 58/255 (22%), Positives = 118/255 (46%), Gaps = 29/255 (11%)
Query: 253 RLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGF 312
R +++ ++ + LL +++P +VA ++K + Y + HD+ ++FA IV F
Sbjct: 1018 RTKIQSMRDQADWLLRNIIPYHVAEQLKVS----------QTYSKNHDSGGVIFASIVNF 1067
Query: 313 TGLASQCT--AQELVKLLNELFGKFDELATE---NHCRRIKILGDCYYCVSGLTQPKT-- 365
+ + +E ++LNEL G FDEL ++ + +IK +G Y SGL +
Sbjct: 1068 SEFYEENYEGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQD 1127
Query: 366 -----DHAHCCVEMGLDMIDTITSVAE-ATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVW 419
+H E +M+ + + +RVG + G + GV+G K YD+W
Sbjct: 1128 GSHPQEHLQILFEFAKEMMRVVDDFNNNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIW 1187
Query: 420 SNDVTLANVMEAAGLPGKVHITKTT---LACLNGDYEVEPGYGHERNSFLKTH---NIET 473
+ V +A+ M+ G+ ++ +++ + L+ + D++ + +KT+
Sbjct: 1188 GDTVNIASRMDTTGVECRIQVSEESYRVLSKMGYDFDYRGTVNVKGKGQMKTYLYPKCTD 1247
Query: 474 FFIVPSHRRKIFPGL 488
++P H+ I P +
Sbjct: 1248 HRVIPQHQLSISPDI 1262
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 117 bits (294), Expect = 5e-26
Identities = 63/193 (32%), Positives = 108/193 (55%), Gaps = 9/193 (4%)
Query: 256 LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGL 315
LE+E +K LL S+ P VA ++ + + + ++ NV++LF+DIVGFT +
Sbjct: 208 LEEEKKKTVDLLCSIFPCEVAQQLWQGQV---------VQAKKFSNVTMLFSDIVGFTAI 258
Query: 316 ASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMG 375
SQC+ +++ +LN L+ +FD+ E +++ +GD Y GL + HA M
Sbjct: 259 CSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMA 318
Query: 376 LDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435
L M++ V + MR+GLH+G V GV+G++ +Y ++ N+VTLAN E+ +P
Sbjct: 319 LKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVP 378
Query: 436 GKVHITKTTLACL 448
K++++ TT L
Sbjct: 379 RKINVSPTTYRLL 391
Score = 88.6 bits (218), Expect = 3e-17
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 19/216 (8%)
Query: 817 AQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPN 876
A E+ + +E+ K +L ++ P VAQ + + +S V ++F+ I
Sbjct: 199 ATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV----VQAKKFSNVTMLFSDIVG 254
Query: 877 FNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTS 936
F + ++ + +LN + FD+ + D+ K++TIG Y A GL S
Sbjct: 255 FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKES 307
Query: 937 GTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQY 996
T H +A A++M ++ DE+ +R+G++ G V AGV+G + P+Y
Sbjct: 308 DT--------HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRY 359
Query: 997 DIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP 1032
++GN V +A++ +S V +I V+ +RLL+ CP
Sbjct: 360 CLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCP 395
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 117 bits (294), Expect = 5e-26
Identities = 63/193 (32%), Positives = 108/193 (55%), Gaps = 9/193 (4%)
Query: 256 LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGL 315
LE+E +K LL S+ P VA ++ + + + ++ NV++LF+DIVGFT +
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQV---------VQAKKFSNVTMLFSDIVGFTAI 493
Query: 316 ASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMG 375
SQC+ +++ +LN L+ +FD+ E +++ +GD Y GL + HA M
Sbjct: 494 CSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMA 553
Query: 376 LDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435
L M++ V + MR+GLH+G V GV+G++ +Y ++ N+VTLAN E+ +P
Sbjct: 554 LKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVP 613
Query: 436 GKVHITKTTLACL 448
K++++ TT L
Sbjct: 614 RKINVSPTTYRLL 626
Score = 88.6 bits (218), Expect = 3e-17
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 19/216 (8%)
Query: 817 AQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPN 876
A E+ + +E+ K +L ++ P VAQ + + +S V ++F+ I
Sbjct: 434 ATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV----VQAKKFSNVTMLFSDIVG 489
Query: 877 FNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTS 936
F + ++ + +LN + FD+ + D+ K++TIG Y A GL S
Sbjct: 490 FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKES 542
Query: 937 GTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQY 996
T H +A A++M ++ DE+ +R+G++ G V AGV+G + P+Y
Sbjct: 543 DT--------HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRY 594
Query: 997 DIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP 1032
++GN V +A++ +S V +I V+ +RLL+ CP
Sbjct: 595 CLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCP 630
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 117 bits (294), Expect = 5e-26
Identities = 63/193 (32%), Positives = 108/193 (55%), Gaps = 9/193 (4%)
Query: 256 LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGL 315
LE+E +K LL S+ P VA ++ + + + ++ NV++LF+DIVGFT +
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQV---------VQAKKFSNVTMLFSDIVGFTAI 493
Query: 316 ASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMG 375
SQC+ +++ +LN L+ +FD+ E +++ +GD Y GL + HA M
Sbjct: 494 CSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMA 553
Query: 376 LDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435
L M++ V + MR+GLH+G V GV+G++ +Y ++ N+VTLAN E+ +P
Sbjct: 554 LKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVP 613
Query: 436 GKVHITKTTLACL 448
K++++ TT L
Sbjct: 614 RKINVSPTTYRLL 626
Score = 88.6 bits (218), Expect = 3e-17
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 19/216 (8%)
Query: 817 AQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPN 876
A E+ + +E+ K +L ++ P VAQ + + +S V ++F+ I
Sbjct: 434 ATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV----VQAKKFSNVTMLFSDIVG 489
Query: 877 FNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTS 936
F + ++ + +LN + FD+ + D+ K++TIG Y A GL S
Sbjct: 490 FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKES 542
Query: 937 GTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQY 996
T H +A A++M ++ DE+ +R+G++ G V AGV+G + P+Y
Sbjct: 543 DT--------HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRY 594
Query: 997 DIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP 1032
++GN V +A++ +S V +I V+ +RLL+ CP
Sbjct: 595 CLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCP 630
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 117 bits (294), Expect = 5e-26
Identities = 63/193 (32%), Positives = 108/193 (55%), Gaps = 9/193 (4%)
Query: 256 LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGL 315
LE+E +K LL S+ P VA ++ + + + ++ NV++LF+DIVGFT +
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQV---------VQAKKFSNVTMLFSDIVGFTAI 493
Query: 316 ASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMG 375
SQC+ +++ +LN L+ +FD+ E +++ +GD Y GL + HA M
Sbjct: 494 CSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMA 553
Query: 376 LDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435
L M++ V + MR+GLH+G V GV+G++ +Y ++ N+VTLAN E+ +P
Sbjct: 554 LKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVP 613
Query: 436 GKVHITKTTLACL 448
K++++ TT L
Sbjct: 614 RKINVSPTTYRLL 626
Score = 88.6 bits (218), Expect = 3e-17
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 19/216 (8%)
Query: 817 AQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPN 876
A E+ + +E+ K +L ++ P VAQ + + +S V ++F+ I
Sbjct: 434 ATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV----VQAKKFSNVTMLFSDIVG 489
Query: 877 FNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTS 936
F + ++ + +LN + FD+ + D+ K++TIG Y A GL S
Sbjct: 490 FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKES 542
Query: 937 GTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQY 996
T H +A A++M ++ DE+ +R+G++ G V AGV+G + P+Y
Sbjct: 543 DT--------HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRY 594
Query: 997 DIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP 1032
++GN V +A++ +S V +I V+ +RLL+ CP
Sbjct: 595 CLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCP 630
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 117 bits (294), Expect = 5e-26
Identities = 63/193 (32%), Positives = 108/193 (55%), Gaps = 9/193 (4%)
Query: 256 LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGL 315
LE+E +K LL S+ P VA ++ + + + ++ NV++LF+DIVGFT +
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQV---------VQAKKFSNVTMLFSDIVGFTAI 493
Query: 316 ASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMG 375
SQC+ +++ +LN L+ +FD+ E +++ +GD Y GL + HA M
Sbjct: 494 CSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMA 553
Query: 376 LDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435
L M++ V + MR+GLH+G V GV+G++ +Y ++ N+VTLAN E+ +P
Sbjct: 554 LKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVP 613
Query: 436 GKVHITKTTLACL 448
K++++ TT L
Sbjct: 614 RKINVSPTTYRLL 626
Score = 88.6 bits (218), Expect = 3e-17
Identities = 58/216 (26%), Positives = 105/216 (48%), Gaps = 19/216 (8%)
Query: 817 AQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPN 876
A E+ + +E+ K +L ++ P VAQ + + +S V ++F+ I
Sbjct: 434 ATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV----VQAKKFSNVTMLFSDIVG 489
Query: 877 FNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTS 936
F + ++ + +LN + FD+ + D+ K++TIG Y A GL S
Sbjct: 490 FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKES 542
Query: 937 GTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQY 996
T H +A A++M ++ DE+ +R+G++ G V AGV+G + P+Y
Sbjct: 543 DT--------HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRY 594
Query: 997 DIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP 1032
++GN V +A++ +S V +I V+ +RLL+ CP
Sbjct: 595 CLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCP 630
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 117 bits (293), Expect = 6e-26
Identities = 62/189 (32%), Positives = 107/189 (56%), Gaps = 9/189 (4%)
Query: 256 LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGL 315
LE+E +K LL S+ P VA ++ + + + ++ NV++LF+DIVGFT +
Sbjct: 443 LEEEKKKTVDLLCSIFPCEVAQQLWQGQV---------VQAKKFSNVTMLFSDIVGFTAI 493
Query: 316 ASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMG 375
SQC+ +++ +LN L+ +FD+ E +++ +GD Y GL + HA M
Sbjct: 494 CSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKESDTHAVQIALMA 553
Query: 376 LDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435
L M++ V + MR+GLH+G V GV+G++ +Y ++ N+VTLAN E+ +P
Sbjct: 554 LKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVP 613
Query: 436 GKVHITKTT 444
K++++ TT
Sbjct: 614 RKINVSPTT 622
Score = 79.3 bits (194), Expect = 2e-14
Identities = 54/210 (25%), Positives = 100/210 (47%), Gaps = 19/210 (9%)
Query: 817 AQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPN 876
A E+ + +E+ K +L ++ P VAQ + + +S V ++F+ I
Sbjct: 434 ATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQV----VQAKKFSNVTMLFSDIVG 489
Query: 877 FNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTS 936
F + ++ + +LN + FD+ + D+ K++TIG Y A GL S
Sbjct: 490 FTAICSQCSP----LQVITMLNALYTRFDQQCGE---LDVYKVETIGDAYCVAGGLHKES 542
Query: 937 GTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQY 996
T H +A A++M ++ DE+ +R+G++ G V AGV+G + P+Y
Sbjct: 543 DT--------HAVQIALMALKMMELSDEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRY 594
Query: 997 DIWGNTVNVASRMDSTGVQGRIQVTEEVHR 1026
++GN V +A++ +S V +I V+ +R
Sbjct: 595 CLFGNNVTLANKFESCSVPRKINVSPTTYR 624
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 117 bits (293), Expect = 6e-26
Identities = 62/193 (32%), Positives = 110/193 (56%), Gaps = 9/193 (4%)
Query: 256 LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGL 315
LE+E +K LL S+ P +VA ++ + ++ ++ D+V++LF+DIVGFT +
Sbjct: 483 LEEEKKKTVDLLYSIFPGDVAQQLWQG---------QQVQARKFDDVTMLFSDIVGFTAI 533
Query: 316 ASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMG 375
+QCT +++ +LNEL+ +FD +++ +GD Y +GL + HA M
Sbjct: 534 CAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGLHRKSLCHAKPIALMA 593
Query: 376 LDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLP 435
L M++ V + MR+G+H+G VL GV+G+R +Y ++ N+VTLA+ E+ P
Sbjct: 594 LKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHP 653
Query: 436 GKVHITKTTLACL 448
+++++ TT L
Sbjct: 654 RRINVSPTTYQLL 666
Score = 90.5 bits (223), Expect = 8e-18
Identities = 71/260 (27%), Positives = 126/260 (48%), Gaps = 25/260 (9%)
Query: 804 QVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQS 863
Q ++ R+D L A E + +E+ K +L+++ P VAQ + + +
Sbjct: 462 QDGLKKRMDKL-KATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLW----QGQQVQARK 516
Query: 864 YSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIG 923
+ V ++F+ I F + ++ + +LNE+ FD + DI K++TIG
Sbjct: 517 FDDVTMLFSDIVGFTAICAQCTP----MQVISMLNELYTRFDHQCG---FLDIYKVETIG 569
Query: 924 STYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGP 983
Y A GL +KS+ H +A A++M ++ +E+ +R+GI+ G
Sbjct: 570 DAYCVAAGLH-------RKSLC-HAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGS 621
Query: 984 VVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRR-CPYHFVCRGKVS 1042
V+AGV+G R P+Y ++GN V +AS+ +S RI V+ ++LL+R + F+ R +
Sbjct: 622 VLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINVSPTTYQLLKREESFTFIPRSREE 681
Query: 1043 VKGKGEM----LTYFLEGRT 1058
+ + YFLE RT
Sbjct: 682 LPDNFPKEIPGICYFLEVRT 701
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 115 bits (288), Expect = 2e-25
Identities = 77/229 (33%), Positives = 123/229 (53%), Gaps = 28/229 (12%)
Query: 245 QARSCIEDRLRL-----EDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRH 299
Q + DRL+L EDE +K + LL S+LP +VA E++ K P + +R+
Sbjct: 367 QELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRH---KRP------VPAKRY 417
Query: 300 DNVSILFADIVGFTGLASQCT----AQELVKLLNELFGKFDELATENH---CRRIKILGD 352
DNV+ILF+ IVGF S+ A ++V LLN+L+ +FD L +++ +GD
Sbjct: 418 DNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGD 477
Query: 353 CYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVD---LNMRVGLHTGRVLCGVL 409
Y VSGL +P HA + LDM++ +A +VD + + +G+HTG V+ GV+
Sbjct: 478 KYMTVSGLPEPCIHHARSICHLALDMME----IAGQVQVDGESVQITIGIHTGEVVTGVI 533
Query: 410 GLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGY 458
G R +Y ++ N V L + E G GK+++++ T CL +P +
Sbjct: 534 GQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQF 582
Score = 110 bits (274), Expect = 1e-23
Identities = 73/240 (30%), Positives = 119/240 (49%), Gaps = 21/240 (8%)
Query: 827 EKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDG 886
EK K D +L+++LP VA P + + Y V ++F+ I FN F +
Sbjct: 386 EKKKTDT--LLYSVLPPSVANELRHKRP----VPAKRYDNVTILFSGIVGFNAFCSKHAS 439
Query: 887 NNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISS 946
++ + LLN++ FD L + + K++T+G YM GL +
Sbjct: 440 GEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLP--------EPCIH 491
Query: 947 HLSTLADFAIEMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVA 1006
H ++ A++M ++ ++ + +GI+ G VV GVIG R P+Y ++GNTVN+
Sbjct: 492 HARSICHLALDMMEIAGQVQVDG-ESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLT 550
Query: 1007 SRMDSTGVQGRIQVTEEVHRLLRR-----CPYHFVCRGKVSVKGKGE-MLTYFLEGRTDG 1060
SR ++TG +G+I V+E +R L +H RG VS+KGK E M +FL + G
Sbjct: 551 SRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTG 610
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 115 bits (287), Expect = 3e-25
Identities = 76/222 (34%), Positives = 123/222 (55%), Gaps = 20/222 (9%)
Query: 245 QARSCIEDRLR-----LEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRH 299
Q S +ED +R LE E +K E+LL +LP +VA +K+ PE
Sbjct: 830 QYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGF--------- 880
Query: 300 DNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSG 359
D V++ F+DIVGFT +++ E+V LLN+L+ FD + + +++ +GD Y SG
Sbjct: 881 DLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASG 940
Query: 360 LTQPK-TDHAHCCVEMGLDMIDTITS--VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQY 416
L + + HA M LD++ ++ + + EV + +R+GLH+G V+ GV+GL +Y
Sbjct: 941 LPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRY 1000
Query: 417 DVWSNDVTLANVMEAAGLPGKVHI---TKTTLACLNGDYEVE 455
++ + V A+ ME+ GLP ++H+ T T L L+ YEVE
Sbjct: 1001 CLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVE 1042
Score = 105 bits (262), Expect = 2e-22
Identities = 74/261 (28%), Positives = 134/261 (51%), Gaps = 26/261 (9%)
Query: 805 VDIRLRLDYLWAAQAE----EEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLY 860
+D LR+ +++ E E E++E K ++L +LP VA+ S + +
Sbjct: 821 IDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAE----SLKKGCTVE 876
Query: 861 YQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIK 920
+ + V + F+ I F + + +E + LLN++ FD ++ D+ K++
Sbjct: 877 PEGFDLVTLYFSDIVGFTT----ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVE 929
Query: 921 TIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFV--LRVG 978
TIG YM A GL +G++ H + +A+ ++++ + + + +R+G
Sbjct: 930 TIGDAYMVASGLPKRNGSR-------HAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIG 982
Query: 979 INVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP--YHFV 1036
++ GPVVAGV+G P+Y ++G+TVN ASRM+STG+ RI V+ +L+ Y
Sbjct: 983 LHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVE 1042
Query: 1037 CRGKVSVKGKGEMLTYFLEGR 1057
RG+ +KGKG T++L G+
Sbjct: 1043 LRGRTELKGKGTEETFWLIGK 1063
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 111 bits (278), Expect = 3e-24
Identities = 76/244 (31%), Positives = 126/244 (51%), Gaps = 23/244 (9%)
Query: 821 EEREDMEKVKLDNR-RILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFND 879
EER + K + D R+ F LLP V + +LY +V + F+ I F
Sbjct: 780 EERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELY----EEVTIYFSDIVGFTT 835
Query: 880 FYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTK 939
+ + +E + +LN+I FD +++ + D+ K++TIG YM A GL +G +
Sbjct: 836 ----ICKYSTPMEVVDMLNDIYKSFDHIVD---HHDVYKVETIGDAYMVASGLPKRNGNR 888
Query: 940 AKKSISSHLSTLADFAIEMFDVLD--EINYQSYNDFVLRVGINVGPVVAGVIGARRPQYD 997
H +A A+E+ + E+ + +R+G++ GP AGV+G + P+Y
Sbjct: 889 -------HAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYC 941
Query: 998 IWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRR--CPYHFVCRGKVSVKGKGEMLTYFLE 1055
++G+TVN ASRM+STG+ RI V+ +L+R C + + RG+ +KG+G TY+L
Sbjct: 942 LFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLT 1001
Query: 1056 GRTD 1059
G D
Sbjct: 1002 GMKD 1005
Score = 103 bits (257), Expect = 9e-22
Identities = 68/232 (29%), Positives = 125/232 (53%), Gaps = 18/232 (7%)
Query: 250 IEDRLRL-EDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFAD 308
+E+R +L + E ++ +RL LLPR V +KE PE ++ V+I F+D
Sbjct: 779 VEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPEL---------YEEVTIYFSD 829
Query: 309 IVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTD-- 366
IVGFT + T E+V +LN+++ FD + + +++ +GD Y SGL PK +
Sbjct: 830 IVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGL--PKRNGN 887
Query: 367 -HAHCCVEMGLDMIDTITS--VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDV 423
HA +M L+++ + + + + + +R+G+H+G GV+G++ +Y ++ + V
Sbjct: 888 RHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTV 947
Query: 424 TLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFF 475
A+ ME+ GLP ++H++ +T+A L E + Y ++LK ET +
Sbjct: 948 NTASRMESTGLPLRIHVSGSTIAILKRT-ECQFLYEVRGETYLKGRGNETTY 998
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 111 bits (278), Expect = 3e-24
Identities = 82/262 (31%), Positives = 135/262 (51%), Gaps = 23/262 (8%)
Query: 205 AKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQRKAFLQARSCIEDRLR-----LEDE 259
A++P L ++ LF +N G I+ S + Q S +ED +R LE E
Sbjct: 789 AEQPELRPSMDHTFDLFKNINK-GRKTNIID--SMLRMLEQYSSNLEDLIRERTEELELE 845
Query: 260 NEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQC 319
+K +RLL +LP +VA +K PE + V++ F+DIVGFT +++
Sbjct: 846 KQKTDRLLTQMLPPSVAEALKTGTPVEPEYF---------EQVTLYFSDIVGFTTISAMS 896
Query: 320 TAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTD-HAHCCVEMGLDM 378
E+V LLN+L+ FD + + +++ +GD Y SGL Q HA M LD+
Sbjct: 897 EPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDI 956
Query: 379 IDTITS--VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPG 436
+ + + + EV + +R+GLH+G + GV+GL +Y ++ + V A+ ME+ GLP
Sbjct: 957 LSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPY 1016
Query: 437 KVHITKTT---LACLNGDYEVE 455
++H+ +T L L+ Y+VE
Sbjct: 1017 RIHVNLSTVGILRALDSGYQVE 1038
Score = 108 bits (271), Expect = 2e-23
Identities = 78/265 (29%), Positives = 131/265 (49%), Gaps = 26/265 (9%)
Query: 805 VDIRLRLDYLWAAQAE----EEREDMEKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLY 860
+D LR+ +++ E E E++E K R+L +LP VA+ P + +
Sbjct: 817 IDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYF 876
Query: 861 YQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIK 920
QV + F+ I F + + +E + LLN++ FD ++ D+ K++
Sbjct: 877 ----EQVTLYFSDIVGFTT----ISAMSEPIEVVDLLNDLYTLFDAIIGSH---DVYKVE 925
Query: 921 TIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDEINYQSYNDFV--LRVG 978
TIG YM A GL +G + H + +A+ ++++ + + + +R+G
Sbjct: 926 TIGDAYMVASGLPQRNGQR-------HAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIG 978
Query: 979 INVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP--YHFV 1036
++ GP VAGV+G P+Y ++G+TVN ASRM+STG+ RI V +LR Y
Sbjct: 979 LHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVE 1038
Query: 1037 CRGKVSVKGKGEMLTYFLEGRTDGN 1061
RG+ +KGKG T++L GR N
Sbjct: 1039 LRGRTELKGKGAEDTFWLVGRRGFN 1063
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 111 bits (277), Expect = 4e-24
Identities = 76/262 (29%), Positives = 134/262 (51%), Gaps = 26/262 (9%)
Query: 806 DIRLRLDYLWAAQAEEEREDMEKVKLDNRR----ILFNLLPAHVAQHFLMSNPRNMDLYY 861
++ LR++ +A E+ E+ + L+ +R +L+ +LP VA+ R +
Sbjct: 800 NLLLRMEQ-YANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQA 854
Query: 862 QSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKT 921
+++ V + F+ I F L + ++ + LLN++ FD +++ D+ K++T
Sbjct: 855 EAFDSVTIYFSDIVGFT----ALSAESTPMQVVTLLNDLYTCFDAIIDNF---DVYKVET 907
Query: 922 IGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDE--INYQSYNDFVLRVGI 979
IG YM GL +G + H +A A+ + D + I ++ ++ LR+G+
Sbjct: 908 IGDAYMVVSGLPGRNGQR-------HAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGV 960
Query: 980 NVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRCP-YHFVCR 1038
+ GPV AGV+G + P+Y ++G+TVN ASRM+S G +I V+ L + R
Sbjct: 961 HTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELR 1020
Query: 1039 GKVSVKGKGEMLTYFLEGRTDG 1060
G V +KGKG+M TY+L G G
Sbjct: 1021 GDVEMKGKGKMRTYWLLGERKG 1042
Score = 110 bits (274), Expect = 1e-23
Identities = 73/222 (32%), Positives = 118/222 (53%), Gaps = 23/222 (10%)
Query: 258 DENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLAS 317
+E K E LL +LP +VA ++K + + D+V+I F+DIVGFT L++
Sbjct: 825 EEKRKAEALLYQILPHSVAEQLKRG---------ETVQAEAFDSVTIYFSDIVGFTALSA 875
Query: 318 QCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLT-QPKTDHAHCCVEMGL 376
+ T ++V LLN+L+ FD + +++ +GD Y VSGL + HA M L
Sbjct: 876 ESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMAL 935
Query: 377 DMIDTITS--VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGL 434
++D ++S + L +R+G+HTG V GV+GL+ +Y ++ + V A+ ME+ G
Sbjct: 936 ALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQ 995
Query: 435 PGKVHITKTT------LAC----LNGDYEVEPGYGHERNSFL 466
K+H++ TT L C L GD E++ G G R +L
Sbjct: 996 ALKIHVSSTTKDALDELGCFQLELRGDVEMK-GKGKMRTYWL 1036
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 110 bits (275), Expect = 7e-24
Identities = 67/204 (32%), Positives = 111/204 (54%), Gaps = 16/204 (7%)
Query: 258 DENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLAS 317
+E K E LL +LP +VA ++K + + D+V+I F+DIVGFT L++
Sbjct: 840 EEKRKAEALLYQILPHSVAEQLKRG---------ETVQAEAFDSVTIYFSDIVGFTALSA 890
Query: 318 QCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCC--VEMG 375
+ T ++V LLN+L+ FD + +++ +GD Y VSGL + H C M
Sbjct: 891 ESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGL-PVRNGRLHACEVARMA 949
Query: 376 LDMIDTITS--VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAG 433
L ++D + S + + L +R+G+HTG V GV+GL+ +Y ++ + V A+ ME+ G
Sbjct: 950 LALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNG 1009
Query: 434 LPGKVHITKTTLACLN--GDYEVE 455
K+H++ T A L G +E+E
Sbjct: 1010 EALKIHLSSETKAVLEEFGGFELE 1033
Score = 107 bits (268), Expect = 5e-23
Identities = 74/249 (29%), Positives = 126/249 (50%), Gaps = 25/249 (10%)
Query: 815 WAAQAEEEREDMEKVKLDNRR----ILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVM 870
+A EE E+ + L+ +R +L+ +LP VA+ R + +++ V +
Sbjct: 823 YANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQL----KRGETVQAEAFDSVTIY 878
Query: 871 FASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAV 930
F+ I F L + ++ + LLN++ FD +++ D+ K++TIG YM
Sbjct: 879 FSDIVGFT----ALSAESTPMQVVTLLNDLYTCFDAVIDNF---DVYKVETIGDAYMVVS 931
Query: 931 GLAPTSGTKAKKSISSHLSTLADFAIEMFDVLDE--INYQSYNDFVLRVGINVGPVVAGV 988
GL +G H +A A+ + D + I ++ LR+GI+ GPV AGV
Sbjct: 932 GLPVRNGRL-------HACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGV 984
Query: 989 IGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRRC-PYHFVCRGKVSVKGKG 1047
+G + P+Y ++G+TVN ASRM+S G +I ++ E +L + RG V +KGKG
Sbjct: 985 VGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKG 1044
Query: 1048 EMLTYFLEG 1056
++ TY+L G
Sbjct: 1045 KVRTYWLLG 1053
>gi|5032007 purine-rich element binding protein A [Homo sapiens]
Length = 322
Score = 37.7 bits (86), Expect = 0.061
Identities = 24/72 (33%), Positives = 37/72 (51%), Gaps = 5/72 (6%)
Query: 2 AGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAAT 61
+G+ GGGGGGGG G GG A G GL+ +E A ++ + + L ++Q A
Sbjct: 28 SGSGGGGGGGGGGGGSGGGGGGAPG-----GLQHETQELASKRVDIQNKRFYLDVKQNAK 82
Query: 62 LKALAVLSLLAG 73
+ L + + AG
Sbjct: 83 GRFLKIAEVGAG 94
>gi|21322252 androgen receptor isoform 1 [Homo sapiens]
Length = 920
Score = 37.4 bits (85), Expect = 0.080
Identities = 17/43 (39%), Positives = 22/43 (51%)
Query: 3 GAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPEL 45
G GGGGGGGG GE G T +GL + +F P++
Sbjct: 460 GGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDV 502
>gi|7662046 myeloid/lymphoid or mixed-lineage leukemia 4 [Homo
sapiens]
Length = 2715
Score = 36.6 bits (83), Expect = 0.14
Identities = 17/30 (56%), Positives = 17/30 (56%)
Query: 3 GAPRGGGGGGGGAGEPGGAERAAGTSRRRG 32
G PRG GGGGG G GAER RR G
Sbjct: 22 GRPRGAGGGGGRGGRGNGAERVRVALRRGG 51
>gi|122937424 one cut homeobox 3 [Homo sapiens]
Length = 494
Score = 36.6 bits (83), Expect = 0.14
Identities = 17/26 (65%), Positives = 18/26 (69%)
Query: 7 GGGGGGGGAGEPGGAERAAGTSRRRG 32
GGGGGGGGAG GGA A G + RG
Sbjct: 57 GGGGGGGGAGGAGGAGSAGGGADFRG 82
>gi|31542255 hypothetical protein LOC140706 [Homo sapiens]
Length = 433
Score = 35.8 bits (81), Expect = 0.23
Identities = 16/23 (69%), Positives = 19/23 (82%), Gaps = 2/23 (8%)
Query: 7 GGGGGGGGAGEPGGA--ERAAGT 27
GGGGGGGGAG+PGG+ R AG+
Sbjct: 252 GGGGGGGGAGKPGGSWERRQAGS 274
>gi|50843837 hypothetical protein LOC55701 [Homo sapiens]
Length = 1519
Score = 35.8 bits (81), Expect = 0.23
Identities = 18/33 (54%), Positives = 18/33 (54%)
Query: 3 GAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRA 35
G RGGGGGG GA P G R G RR RA
Sbjct: 353 GELRGGGGGGQGAEGPPGTPRRTGKGNRRKKRA 385
>gi|238859557 regulatory factor X1 [Homo sapiens]
Length = 979
Score = 35.4 bits (80), Expect = 0.30
Identities = 15/25 (60%), Positives = 16/25 (64%)
Query: 3 GAPRGGGGGGGGAGEPGGAERAAGT 27
G GGGGGGGG+G GG AGT
Sbjct: 388 GGGGGGGGGGGGSGSTGGGGSGAGT 412
Score = 31.2 bits (69), Expect = 5.7
Identities = 13/24 (54%), Positives = 14/24 (58%)
Query: 3 GAPRGGGGGGGGAGEPGGAERAAG 26
G GGGGGGGG G GG+ G
Sbjct: 382 GGGSGGGGGGGGGGGGGGSGSTGG 405
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.139 0.421
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,934,753
Number of Sequences: 37866
Number of extensions: 1902281
Number of successful extensions: 16660
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 116
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 14482
Number of HSP's gapped (non-prelim): 1443
length of query: 1119
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1006
effective length of database: 13,968,660
effective search space: 14052471960
effective search space used: 14052471960
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.