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Search of human proteins with 29788751
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
(1220 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 2460 0.0
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 2314 0.0
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 1518 0.0
gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 1475 0.0
gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 771 0.0
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] 207 4e-53
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] 207 6e-53
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] 207 6e-53
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 205 2e-52
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 205 2e-52
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 205 2e-52
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 205 2e-52
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] 185 3e-46
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] 168 3e-41
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] 164 6e-40
gi|4758156 diacylglycerol kinase, iota [Homo sapiens] 155 2e-37
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] 152 2e-36
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] 152 2e-36
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] 152 2e-36
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] 152 2e-36
gi|40806175 diacylglycerol kinase, theta [Homo sapiens] 131 3e-30
gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1... 69 4e-11
gi|47157325 protein kinase C, delta [Homo sapiens] 65 3e-10
gi|31377782 protein kinase C, delta [Homo sapiens] 65 3e-10
gi|28557781 protein kinase C, eta [Homo sapiens] 65 5e-10
gi|5453976 protein kinase C, theta [Homo sapiens] 64 9e-10
gi|120659787 protein kinase D2 isoform B [Homo sapiens] 63 1e-09
gi|120659785 protein kinase D2 isoform A [Homo sapiens] 63 1e-09
gi|120659782 protein kinase D2 isoform A [Homo sapiens] 63 1e-09
gi|19923468 protein kinase D2 isoform A [Homo sapiens] 63 1e-09
>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
Length = 1220
Score = 2460 bits (6376), Expect = 0.0
Identities = 1220/1220 (100%), Positives = 1220/1220 (100%)
Query: 1 MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQ 60
MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQ
Sbjct: 1 MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQ 60
Query: 61 IRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEAST 120
IRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEAST
Sbjct: 61 IRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEAST 120
Query: 121 KNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYA 180
KNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYA
Sbjct: 121 KNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYA 180
Query: 181 CSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED 240
CSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED
Sbjct: 181 CSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED 240
Query: 241 EDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPL 300
EDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPL
Sbjct: 241 EDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPL 300
Query: 301 GQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPA 360
GQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPA
Sbjct: 301 GQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPA 360
Query: 361 QVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTG 420
QVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTG
Sbjct: 361 QVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTG 420
Query: 421 NDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEAS 480
NDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEAS
Sbjct: 421 NDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEAS 480
Query: 481 EEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVA 540
EEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVA
Sbjct: 481 EEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVA 540
Query: 541 DAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLG 600
DAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLG
Sbjct: 541 DAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLG 600
Query: 601 DDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTE 660
DDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTE
Sbjct: 601 DDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTE 660
Query: 661 TDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRII 720
TDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRII
Sbjct: 661 TDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRII 720
Query: 721 CPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLD 780
CPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLD
Sbjct: 721 CPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLD 780
Query: 781 AKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLP 840
AKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLP
Sbjct: 781 AKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLP 840
Query: 841 SLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQH 900
SLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQH
Sbjct: 841 SLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQH 900
Query: 901 HRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWE 960
HRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWE
Sbjct: 901 HRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWE 960
Query: 961 DKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQEL 1020
DKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQEL
Sbjct: 961 DKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQEL 1020
Query: 1021 AHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEER 1080
AHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEER
Sbjct: 1021 AHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEER 1080
Query: 1081 VSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQK 1140
VSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQK
Sbjct: 1081 VSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQK 1140
Query: 1141 QKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGH 1200
QKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGH
Sbjct: 1141 QKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGIPKVGH 1200
Query: 1201 VKRILQGIKELGRSTPQSEV 1220
VKRILQGIKELGRSTPQSEV
Sbjct: 1201 VKRILQGIKELGRSTPQSEV 1220
>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
Length = 1164
Score = 2314 bits (5997), Expect = 0.0
Identities = 1147/1147 (100%), Positives = 1147/1147 (100%)
Query: 1 MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQ 60
MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQ
Sbjct: 1 MAGAGGQHHPPGAAGGAAAGAGAAVTSAAASAGPGEDSSDSEAEQEGPQKLIRKVSTSGQ 60
Query: 61 IRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEAST 120
IRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEAST
Sbjct: 61 IRTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEAST 120
Query: 121 KNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYA 180
KNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYA
Sbjct: 121 KNANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYA 180
Query: 181 CSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED 240
CSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED
Sbjct: 181 CSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED 240
Query: 241 EDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPL 300
EDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPL
Sbjct: 241 EDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPL 300
Query: 301 GQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPA 360
GQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPA
Sbjct: 301 GQCKVSIIPPIALNSTDSDGFCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPA 360
Query: 361 QVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTG 420
QVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTG
Sbjct: 361 QVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTG 420
Query: 421 NDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEAS 480
NDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEAS
Sbjct: 421 NDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASLLPGPPEAS 480
Query: 481 EEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVA 540
EEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVA
Sbjct: 481 EEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVA 540
Query: 541 DAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLG 600
DAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLG
Sbjct: 541 DAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLG 600
Query: 601 DDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTE 660
DDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTE
Sbjct: 601 DDVTKPSSQKAVKPREIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPANQSSDYDSTE 660
Query: 661 TDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRII 720
TDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRII
Sbjct: 661 TDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAASKENLPVLNTRII 720
Query: 721 CPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLD 780
CPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLD
Sbjct: 721 CPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLD 780
Query: 781 AKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLP 840
AKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLP
Sbjct: 781 AKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLP 840
Query: 841 SLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQH 900
SLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQH
Sbjct: 841 SLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQH 900
Query: 901 HRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWE 960
HRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWE
Sbjct: 901 HRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWE 960
Query: 961 DKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQEL 1020
DKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQEL
Sbjct: 961 DKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQEL 1020
Query: 1021 AHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEER 1080
AHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEER
Sbjct: 1021 AHAVNACSHALNKANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEER 1080
Query: 1081 VSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQK 1140
VSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQK
Sbjct: 1081 VSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQK 1140
Query: 1141 QKTSSQP 1147
QKTSSQP
Sbjct: 1141 QKTSSQP 1147
>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
sapiens]
Length = 1214
Score = 1518 bits (3929), Expect = 0.0
Identities = 794/1224 (64%), Positives = 931/1224 (76%), Gaps = 34/1224 (2%)
Query: 17 AAAGAGAAVTSAAASAGPGEDSSDSEAEQE--GPQKLIRKVSTSGQIRTKTSIKEGQLLK 74
AAAGA P E+SSDSE E E PQKLIRKVSTSGQIR KT IKEG L K
Sbjct: 3 AAAGAPPPGPPQPPPPPPPEESSDSEPEAEPGSPQKLIRKVSTSGQIRQKTIIKEGMLTK 62
Query: 75 QTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNANNSFTIITPFR 134
Q +SFQR K+RYFKLRGRTLYYAK +KS+IFDEVDL+DASVAE+STKN NNSFT+ITP R
Sbjct: 63 QNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNNSFTVITPCR 122
Query: 135 RLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRE 194
+L+LCA+NRKEMEDWI++LK+VQ RE +E Q++++HFSGMHNWYACSHARPT+CNVCRE
Sbjct: 123 KLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSHARPTYCNVCRE 182
Query: 195 SLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGN 254
+LSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED DG+AMPHQWLEGN
Sbjct: 183 ALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMPHQWLEGN 242
Query: 255 LPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCKVSIIPPIALN 314
LPVSAKC VCDKTCGSVLRLQDW+CLWCK MVHT+CK+ CPLG CKVS+IPP ALN
Sbjct: 243 LPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSVIPPTALN 302
Query: 315 STDSDGFCRATF-SFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLG 373
S DSDGF +A+ C SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLG
Sbjct: 303 SIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLG 362
Query: 374 LRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSY 433
LRLFQKFD FRILVCGGDGSVGWVLSEID LNL+KQCQLGVLPLGTGNDLARVLGWG +
Sbjct: 363 LRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSAC 422
Query: 434 DDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKAS---LLPGPPEASEEFYMTIYED 490
DDDTQLPQILEKLERASTKMLDRWS+M YE KLP +AS + E SE + YED
Sbjct: 423 DDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSEDSEVQQILFYED 482
Query: 491 SVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVVADAVASKCSVL 550
SVA HL+KIL SD+H+VVISSAK LCETVKDFVA+V K Y+KT E++ ++ +A KCSVL
Sbjct: 483 SVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMAKKCSVL 542
Query: 551 NEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQLGDDVTKPSSQK 610
EKL+ LL+ L +SQA+ LP P I EE S G + ++L P+ +
Sbjct: 543 KEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRLVASAC-PARPQ 601
Query: 611 AVKPRE-IMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEP------ANQSSDYDSTETDE 663
+PRE +MLRANSLKKA+RQ+IE K +D+ E ++S +
Sbjct: 602 IFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSESEEKMDHRVCP 661
Query: 664 SKEEAKDDGAKESITVKTAPRSP-DARASYGH-SQTDSVPGPAVAASKENLPVLNTRIIC 721
++ G + + + +SP + S G S S P S++ LP LNT+I+
Sbjct: 662 PLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDGLPALNTKILY 721
Query: 722 PGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCVMNNYFGIGLDA 781
P +RAG++ S+ G S+I+++L+ N DPF + P ++++ Y+EKCVMNNYFGIGLDA
Sbjct: 722 PNVRAGMSGSLPGGSVISRLLI-NADPFNSEP------ETLEYYTEKCVMNNYFGIGLDA 774
Query: 782 KISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQLECDGQYIPLPS 841
KISL+FNNKR+EHPEKCRSRTKN+MWYGVLGT+ELL R+YKNLEQ+V LECDG+ IPLPS
Sbjct: 775 KISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPS 834
Query: 842 LQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQMAVSRVIKLQHH 901
LQGIAVLNIPSYAGGTNFWGGTKEDD FAAPSFDDKILEVVA+F SMQMAVSRVI+LQHH
Sbjct: 835 LQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHH 894
Query: 902 RIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDRAFESTLKSWED 961
RIAQCRTVKI+I GDEGVPVQVDGEAWVQPPG I+IVHKNRAQ LTRDRAFESTLKSWED
Sbjct: 895 RIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKSWED 954
Query: 962 KQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAATIHCLLEQELA 1021
KQKC+ +P + H L+ EE +QM QAA LI I + A H +EQELA
Sbjct: 955 KQKCELPRPPSCS----LHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELA 1010
Query: 1022 HAVNACSHALNK--ANPRCPESLTRDTATEIAINVKALYNETESLLVGRVPLQLESPHEE 1079
HAVNA S ++++ PR E L E+ N +AL +ETE LL G++ LQL+ P +E
Sbjct: 1011 HAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKE 1070
Query: 1080 RVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFRIVPKFKKEKVQ 1139
++ +AL ++ +L++L + PWL P ++E +D KR +RS FR+V KFKKEK
Sbjct: 1071 QLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKR-SRSGKFRLVTKFKKEKNN 1129
Query: 1140 KQKTS----SQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDLKDLGI 1195
K K + PV WGTEEVAAWL+ L+L EYKDIF RHDIRG+ELLHLERRDLKDLG+
Sbjct: 1130 KNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGV 1189
Query: 1196 PKVGHVKRILQGIKELGRSTPQSE 1219
KVGH+KRIL GIKEL RS P E
Sbjct: 1190 TKVGHMKRILCGIKELSRSAPAVE 1213
>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
Length = 1170
Score = 1475 bits (3818), Expect = 0.0
Identities = 764/1175 (65%), Positives = 901/1175 (76%), Gaps = 32/1175 (2%)
Query: 64 KTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNA 123
+T IKEG L KQ +SFQR K+RYFKLRGRTLYYAK +KS+IFDEVDL+DASVAE+STKN
Sbjct: 8 QTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV 67
Query: 124 NNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSH 183
NNSFT+ITP R+L+LCA+NRKEMEDWI++LK+VQ RE +E Q++++HFSGMHNWYACSH
Sbjct: 68 NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH 127
Query: 184 ARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDG 243
ARPT+CNVCRE+LSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED DG
Sbjct: 128 ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG 187
Query: 244 VAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQC 303
+AMPHQWLEGNLPVSAKC VCDKTCGSVLRLQDW+CLWCK MVHT+CK+ CPLG C
Sbjct: 188 IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC 247
Query: 304 KVSIIPPIALNSTDSDGFCRATF-SFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 362
KVS+IPP ALNS DSDGF +A+ C SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV
Sbjct: 248 KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 307
Query: 363 FDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGND 422
FDLMNGGPHLGLRLFQKFD FRILVCGGDGSVGWVLSEID LNL+KQCQLGVLPLGTGND
Sbjct: 308 FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND 367
Query: 423 LARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKAS---LLPGPPEA 479
LARVLGWG + DDDTQLPQILEKLERASTKMLDRWS+M YE KLP +AS + E
Sbjct: 368 LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED 427
Query: 480 SEEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVV 539
SE + YEDSVA HL+KIL SD+H+VVISSAK LCETVKDFVA+V K Y+KT E++
Sbjct: 428 SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE 487
Query: 540 ADAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQL 599
++ +A KCSVL EKL+ LL+ L +SQA+ LP P I EE S G + ++L
Sbjct: 488 SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL 547
Query: 600 GDDVTKPSSQKAVKPRE-IMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEP------ANQ 652
P+ + +PRE +MLRANSLKKA+RQ+IE K +D+ E ++
Sbjct: 548 VASAC-PARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSE 606
Query: 653 SSDYDSTETDESKEEAKDDGAKESITVKTAPRSP-DARASYGH-SQTDSVPGPAVAASKE 710
S + ++ G + + + +SP + S G S S P S++
Sbjct: 607 SEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRD 666
Query: 711 NLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCV 770
LP LNT+I+ P +RAG++ S+ G S+I+++L+ N DPF + P ++++ Y+EKCV
Sbjct: 667 GLPALNTKILYPNVRAGMSGSLPGGSVISRLLI-NADPFNSEP------ETLEYYTEKCV 719
Query: 771 MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQL 830
MNNYFGIGLDAKISL+FNNKR+EHPEKCRSRTKN+MWYGVLGT+ELL R+YKNLEQ+V L
Sbjct: 720 MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLL 779
Query: 831 ECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQM 890
ECDG+ IPLPSLQGIAVLNIPSYAGGTNFWGGTKEDD FAAPSFDDKILEVVA+F SMQM
Sbjct: 780 ECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQM 839
Query: 891 AVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDR 950
AVSRVI+LQHHRIAQCRTVKI+I GDEGVPVQVDGEAWVQPPG I+IVHKNRAQ LTRDR
Sbjct: 840 AVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDR 899
Query: 951 AFESTLKSWEDKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAA 1010
AFESTLKSWEDKQKC+ +P + H L+ EE +QM QAA LI I + A
Sbjct: 900 AFESTLKSWEDKQKCELPRPPSCS----LHPEMLSEEEATQMDQFGQAAGVLIHSIREIA 955
Query: 1011 TIHCLLEQELAHAVNACSHALNK--ANPRCPESLTRDTATEIAINVKALYNETESLLVGR 1068
H +EQELAHAVNA S ++++ PR E L E+ N +AL +ETE LL G+
Sbjct: 956 QSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGK 1015
Query: 1069 VPLQLESPHEERVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFR 1128
+ LQL+ P +E++ +AL ++ +L++L + PWL P ++E +D KR +RS FR
Sbjct: 1016 MALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKR-SRSGKFR 1074
Query: 1129 IVPKFKKEKVQKQKTS----SQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLH 1184
+V KFKKEK K K + PV WGTEEVAAWL+ L+L EYKDIF RHDIRG+ELLH
Sbjct: 1075 LVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLH 1134
Query: 1185 LERRDLKDLGIPKVGHVKRILQGIKELGRSTPQSE 1219
LERRDLKDLG+ KVGH+KRIL GIKEL RS P E
Sbjct: 1135 LERRDLKDLGVTKVGHMKRILCGIKELSRSAPAVE 1169
>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
Length = 1271
Score = 771 bits (1990), Expect = 0.0
Identities = 456/1118 (40%), Positives = 642/1118 (57%), Gaps = 114/1118 (10%)
Query: 62 RTKTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTK 121
R K +KEG +LK +SF+RWK RYF ++G+ LY+A F+ +DLS A+VAE+S +
Sbjct: 213 RIKKILKEGPMLKNCNSFKRWKLRYFLVQGQKLYFAHHPAFAHFETIDLSQATVAESSCR 272
Query: 122 NANNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEV-AQFNVEHFSGMHNWYA 180
N +SF +ITP R++ L A NRK+ME+WI+ +K++Q E Y++ A N GMH WY+
Sbjct: 273 NLCHSFCVITPQRKITLAAPNRKDMEEWINIIKTIQQGEIYKIPAAENNPFLVGMHCWYS 332
Query: 181 CSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED 240
R CNVCRES+ ++ + CEVCK K+H+ CA+RA+ +CKW TL SI D++
Sbjct: 333 SYSHRTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWNTL-SITDDLLLP 391
Query: 241 EDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPL 300
D V MPHQW+EGN+PVS++CAVC ++CGS RLQD++CLWC + VH C+ + C
Sbjct: 392 ADEVNMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRFSKECCF 451
Query: 301 GQCKVSIIPPIALNSTDSDGFCRATFSF--------CVSPLLVFVNSKSGDNQGVKFLRR 352
+ S+IPP AL+ DG + F C PLL+F+NSKSGD+QG+ FLR+
Sbjct: 452 RSHRSSVIPPTALSDPKGDGQLVVSSDFWNLDWSSACSCPLLIFINSKSGDHQGIVFLRK 511
Query: 353 FKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQL 412
FKQ LNP+QVFDL+ GGP GL +F+ F FRILVCGGDGSV WVLS ID L+++CQL
Sbjct: 512 FKQYLNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGSVSWVLSLIDAFGLHEKCQL 571
Query: 413 GVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKASL 472
V+PLGTGNDLARVLGWG ++ IL ++E+AS ++LDRWS+M E P + L
Sbjct: 572 AVIPLGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASVRILDRWSVMIRE--TPRQTPL 629
Query: 473 LPGPPEASE---EFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKT 529
L G E E + +S AT L KIL + +I + + LC V+DFV + K
Sbjct: 630 LKGQVEMDVPRFEAAAIQHLESAATELNKILKAKYPTEMIIATRFLCSAVEDFVVDIVKA 689
Query: 530 YDKTLENAVVADAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSE 589
+ + +N +V K ++ ++L L+ L ++ A + E S+
Sbjct: 690 WGQIKQNNTAIVSVILKSDLMYDRLSVLIDVLAEEAAAT--------------SAEKSAT 735
Query: 590 ESLGESKEQLGDDVTKPSSQKAVKPR-EIMLRANSLKKAVRQVIEEAGKVMDDPTVHPCE 648
E SK + P K + E+ +A SL+K+++ +I + + +D+ +
Sbjct: 736 EYADSSKADRKPFI--PQIDHIAKCKLELATKAQSLQKSLKLIIFQVEQALDEESRQTIS 793
Query: 649 PANQSSDYDSTETDESKEEAKDDGAKESITVKTAPRSPDARASYGHSQTDSVPGPAVAAS 708
N SS + + E + T+PR R +
Sbjct: 794 VKNFSSTFFLEDDPEDINQ-------------TSPRRRSRRGTLSS-------------- 826
Query: 709 KENLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEK 768
+S+ + N N+D TP +S+ + EK
Sbjct: 827 --------------------ISSLKSEDLDN----LNLDHLHFTP------ESI-RFKEK 855
Query: 769 CVMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRV 828
CVMNNYFGIGLDAKISL+FN +R+EHP + SR KN MWYG+LGT+ELLQRSY+ LE+RV
Sbjct: 856 CVMNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERV 915
Query: 829 QLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSM 888
LECDG+ I LP+LQGI VLNI SYAGG NFWG + AP+ DD LEVVAIF S+
Sbjct: 916 HLECDGETISLPNLQGIVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAIFGSV 975
Query: 889 QMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTR 948
QMA+SR+I L HHRIAQC V ITI G+EG+PVQVDGEAW+Q PG+IKI +KN AQMLTR
Sbjct: 976 QMAMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKNAAQMLTR 1035
Query: 949 DRAFESTLKSWEDKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICD 1008
DR FE+++K WE K P + + L+ EE +QMQ ++ AE LI+++ D
Sbjct: 1036 DRDFENSMKMWEYKHTEIQAAPQPQLD-FQDSQESLSDEEYAQMQHLARLAENLISKLND 1094
Query: 1009 AATIHCLLEQELAHAVNACSHALN-------------KANPRCPESLTRDTATEIAINVK 1055
+ IH + L +VNA ++ LN A+ E+L+R+ A ++ ++K
Sbjct: 1095 LSKIHQHV-SVLMGSVNASANILNDIFYGQDSGNEMGAASCIPIETLSRNDAVDVTFSLK 1153
Query: 1056 ALYNETESLLVGRVPLQLESPHEERVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPM 1115
LY++T + L ++ E E + +AL ++ E +KL+EI W+ I P EE
Sbjct: 1154 GLYDDTTAFLDEKLLRSAED--ETALQSALDAMNKEFKKLSEIDWMNPIFVP---EEKSS 1208
Query: 1116 DCTKRNNRSTVFRIVPKFKKEKVQKQK--TSSQPVQKW 1151
D R+ R + PK K+KV++++ S Q VQ +
Sbjct: 1209 DTDSRSLRLKI--KFPKLGKKKVEEERKPKSGQSVQSF 1244
>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
Length = 791
Score = 207 bits (528), Expect = 4e-53
Identities = 119/303 (39%), Positives = 154/303 (50%), Gaps = 29/303 (9%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
G H W +PT+CN C L GV GL C CK+ H+RC R C T +
Sbjct: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKA- 328
Query: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
G M H W+EGN S KC C K+ + C+WC+ H C+
Sbjct: 329 ------KRSGEVMQHAWVEGNS--SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE-- 378
Query: 294 YHPICPLGQCKVSIIPPIAL-------NSTDSDGFCRATFSFCVS----------PLLVF 336
+C G+ + I+ P ++ SDG A + PLLV
Sbjct: 379 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438
Query: 337 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGW 396
VN KSG QG + LR+F LLNP QVF+L NGGP GL F+ +FR+L CGGDG+VGW
Sbjct: 439 VNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGW 498
Query: 397 VLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDR 456
+L IDK N K + VLPLGTGNDLAR L WGG Y+ + L +IL+ +E++ MLDR
Sbjct: 499 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 557
Query: 457 WSI 459
W +
Sbjct: 558 WHL 560
Score = 146 bits (369), Expect = 1e-34
Identities = 83/196 (42%), Positives = 114/196 (58%), Gaps = 21/196 (10%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
+MNNYF IG+DA I+ F+ RE+HPEK SR KN +WY GT E + K L ++
Sbjct: 578 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 637
Query: 830 LECDGQYIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDI----------------FAA 871
LECDG + L + L+GIA+LNIPS GGTN WG K++ F
Sbjct: 638 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 697
Query: 872 PSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQ 930
D++LEVV + +M+M + +K R+AQC +V TI ++ +P+QVDGE W+Q
Sbjct: 698 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 755
Query: 931 PPGIIKIVHKNRAQML 946
P IKI HKN+A M+
Sbjct: 756 PCCTIKITHKNQAPMM 771
>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
Length = 773
Score = 207 bits (526), Expect = 6e-53
Identities = 121/330 (36%), Positives = 155/330 (46%), Gaps = 56/330 (16%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
G H W +P +CN+C L GV GL C CK+ H+RC RA +C T + S
Sbjct: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKS- 301
Query: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
+ M H W+EGN P KC C KT L C+WC+ +H C
Sbjct: 302 ------KRNTDVMHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353
Query: 294 YHPICPLGQCKVSIIPPIAL---------------------------------------- 313
P C G K I+PP +
Sbjct: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413
Query: 314 -----NSTDSDGF-CRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 367
NS DG + T PLLVFVN KSG QG + R+F+ LLNP QV+ L
Sbjct: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473
Query: 368 GGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVL 427
GP GL F+ +FR+L CGGDG+VGWVL I+K N+ K + +LPLGTGNDLAR L
Sbjct: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533
Query: 428 GWGGSYDDDTQLPQILEKLERASTKMLDRW 457
WGG Y+ + L +IL+ +E ++ MLDRW
Sbjct: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562
Score = 127 bits (320), Expect = 5e-29
Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
++NNYF IG+DA I+ F+ RE+HPEK SR KN WY GT E + K L + V+
Sbjct: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
Query: 830 LECDGQYIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 865
+ECDG I L SL+GIA+LNIPS GG+N WG +K +
Sbjct: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
Query: 866 DDIFAAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVD 924
+ FA+ D++LEVV + +M+M + +K R+AQC V I + +P+Q+D
Sbjct: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
Query: 925 GEAWVQPP 932
GE W+Q P
Sbjct: 760 GEPWMQTP 767
>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
Length = 804
Score = 207 bits (526), Expect = 6e-53
Identities = 121/330 (36%), Positives = 155/330 (46%), Gaps = 56/330 (16%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
G H W +P +CN+C L GV GL C CK+ H+RC RA +C T + S
Sbjct: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKS- 301
Query: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
+ M H W+EGN P KC C KT L C+WC+ +H C
Sbjct: 302 ------KRNTDVMHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353
Query: 294 YHPICPLGQCKVSIIPPIAL---------------------------------------- 313
P C G K I+PP +
Sbjct: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413
Query: 314 -----NSTDSDGF-CRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 367
NS DG + T PLLVFVN KSG QG + R+F+ LLNP QV+ L
Sbjct: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473
Query: 368 GGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVL 427
GP GL F+ +FR+L CGGDG+VGWVL I+K N+ K + +LPLGTGNDLAR L
Sbjct: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533
Query: 428 GWGGSYDDDTQLPQILEKLERASTKMLDRW 457
WGG Y+ + L +IL+ +E ++ MLDRW
Sbjct: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562
Score = 143 bits (361), Expect = 9e-34
Identities = 83/202 (41%), Positives = 114/202 (56%), Gaps = 27/202 (13%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
++NNYF IG+DA I+ F+ RE+HPEK SR KN WY GT E + K L + V+
Sbjct: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641
Query: 830 LECDGQYIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 865
+ECDG I L SL+GIA+LNIPS GG+N WG +K +
Sbjct: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701
Query: 866 DDIFAAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVD 924
+ FA+ D++LEVV + +M+M + +K R+AQC V I + +P+Q+D
Sbjct: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759
Query: 925 GEAWVQPPGIIKIVHKNRAQML 946
GE W+Q P IKI HKN+A ML
Sbjct: 760 GEPWMQTPCTIKITHKNQAPML 781
>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 205 bits (521), Expect = 2e-52
Identities = 125/324 (38%), Positives = 166/324 (51%), Gaps = 33/324 (10%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
G H W RP +CN+C S+ G+ GLSC +CK+ H +CA++A C+ +T A
Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
Query: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
KDI GV H W+ G S +C C K L C+WC +H C
Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
Query: 294 YHPICPLGQCKVSIIPPIAL------------NSTDS----DGFCRATFSFC-------V 330
C G + I+PP ++ NS S D +T
Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
Query: 331 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGG 390
PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ + RILVCGG
Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
Query: 391 DGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERAS 450
DG+VGW+L IDK NL + VLPLGTGNDLAR L WGG Y+ L +IL+ LE +
Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
Query: 451 TKMLDRWSIMTYELKLPPKASLLP 474
+DRWS+ + K+ +P
Sbjct: 494 VVHMDRWSVEVIPQQTEEKSDPVP 517
Score = 127 bits (320), Expect = 5e-29
Identities = 78/203 (38%), Positives = 112/203 (55%), Gaps = 28/203 (13%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
++NNYF IG+DA I+ F+ RE++PEK SR KN +WY T E + + K LE+ +
Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
Query: 830 LECDGQYIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDIF---------------- 869
+E G+ + L SL+GIAVLNIPS GG+N WG T+ DI+
Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
Query: 870 -----AAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQV 923
P DK LEVV + +++M + +K R+A+C +IT + +P+Q+
Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
Query: 924 DGEAWVQPPGIIKIVHKNRAQML 946
DGE W+Q P IKI HKN+ ML
Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720
>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 205 bits (521), Expect = 2e-52
Identities = 125/324 (38%), Positives = 166/324 (51%), Gaps = 33/324 (10%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
G H W RP +CN+C S+ G+ GLSC +CK+ H +CA++A C+ +T A
Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
Query: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
KDI GV H W+ G S +C C K L C+WC +H C
Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
Query: 294 YHPICPLGQCKVSIIPPIAL------------NSTDS----DGFCRATFSFC-------V 330
C G + I+PP ++ NS S D +T
Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
Query: 331 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGG 390
PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ + RILVCGG
Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
Query: 391 DGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERAS 450
DG+VGW+L IDK NL + VLPLGTGNDLAR L WGG Y+ L +IL+ LE +
Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
Query: 451 TKMLDRWSIMTYELKLPPKASLLP 474
+DRWS+ + K+ +P
Sbjct: 494 VVHMDRWSVEVIPQQTEEKSDPVP 517
Score = 127 bits (320), Expect = 5e-29
Identities = 78/203 (38%), Positives = 112/203 (55%), Gaps = 28/203 (13%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
++NNYF IG+DA I+ F+ RE++PEK SR KN +WY T E + + K LE+ +
Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
Query: 830 LECDGQYIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDIF---------------- 869
+E G+ + L SL+GIAVLNIPS GG+N WG T+ DI+
Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
Query: 870 -----AAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQV 923
P DK LEVV + +++M + +K R+A+C +IT + +P+Q+
Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
Query: 924 DGEAWVQPPGIIKIVHKNRAQML 946
DGE W+Q P IKI HKN+ ML
Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720
>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 205 bits (521), Expect = 2e-52
Identities = 125/324 (38%), Positives = 166/324 (51%), Gaps = 33/324 (10%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
G H W RP +CN+C S+ G+ GLSC +CK+ H +CA++A C+ +T A
Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
Query: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
KDI GV H W+ G S +C C K L C+WC +H C
Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
Query: 294 YHPICPLGQCKVSIIPPIAL------------NSTDS----DGFCRATFSFC-------V 330
C G + I+PP ++ NS S D +T
Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
Query: 331 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGG 390
PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ + RILVCGG
Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
Query: 391 DGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERAS 450
DG+VGW+L IDK NL + VLPLGTGNDLAR L WGG Y+ L +IL+ LE +
Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
Query: 451 TKMLDRWSIMTYELKLPPKASLLP 474
+DRWS+ + K+ +P
Sbjct: 494 VVHMDRWSVEVIPQQTEEKSDPVP 517
Score = 127 bits (320), Expect = 5e-29
Identities = 78/203 (38%), Positives = 112/203 (55%), Gaps = 28/203 (13%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
++NNYF IG+DA I+ F+ RE++PEK SR KN +WY T E + + K LE+ +
Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
Query: 830 LECDGQYIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDIF---------------- 869
+E G+ + L SL+GIAVLNIPS GG+N WG T+ DI+
Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
Query: 870 -----AAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQV 923
P DK LEVV + +++M + +K R+A+C +IT + +P+Q+
Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
Query: 924 DGEAWVQPPGIIKIVHKNRAQML 946
DGE W+Q P IKI HKN+ ML
Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720
>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
Length = 735
Score = 205 bits (521), Expect = 2e-52
Identities = 125/324 (38%), Positives = 166/324 (51%), Gaps = 33/324 (10%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
G H W RP +CN+C S+ G+ GLSC +CK+ H +CA++A C+ +T A
Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261
Query: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
KDI GV H W+ G S +C C K L C+WC +H C
Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314
Query: 294 YHPICPLGQCKVSIIPPIAL------------NSTDS----DGFCRATFSFC-------V 330
C G + I+PP ++ NS S D +T
Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374
Query: 331 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGG 390
PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ + RILVCGG
Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434
Query: 391 DGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERAS 450
DG+VGW+L IDK NL + VLPLGTGNDLAR L WGG Y+ L +IL+ LE +
Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493
Query: 451 TKMLDRWSIMTYELKLPPKASLLP 474
+DRWS+ + K+ +P
Sbjct: 494 VVHMDRWSVEVIPQQTEEKSDPVP 517
Score = 127 bits (320), Expect = 5e-29
Identities = 78/203 (38%), Positives = 112/203 (55%), Gaps = 28/203 (13%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
++NNYF IG+DA I+ F+ RE++PEK SR KN +WY T E + + K LE+ +
Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579
Query: 830 LECDGQYIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDIF---------------- 869
+E G+ + L SL+GIAVLNIPS GG+N WG T+ DI+
Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639
Query: 870 -----AAPSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQV 923
P DK LEVV + +++M + +K R+A+C +IT + +P+Q+
Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697
Query: 924 DGEAWVQPPGIIKIVHKNRAQML 946
DGE W+Q P IKI HKN+ ML
Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720
>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
Length = 567
Score = 185 bits (469), Expect = 3e-46
Identities = 138/431 (32%), Positives = 196/431 (45%), Gaps = 71/431 (16%)
Query: 176 HNWYACS-HARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNN--CKWTTLAS 232
H W ++PT+C VC + + G C+ C + + C +A CK L +
Sbjct: 60 HGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115
Query: 233 IGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTAC-- 290
K + AMPH W+ GN+P+ + C VC + CG +L D++C+WC+ VH C
Sbjct: 116 DTKVLD------AMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMK 169
Query: 291 KDLYHPICPLGQCKVSIIPPIALNSTDSDGFCRAT-FSFCVS-------PLLVFVNSKSG 342
L + C G+ K IIPP L S + + T + S PL++ NS+SG
Sbjct: 170 NSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSG 229
Query: 343 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRL--FQKFDNFRILVCGGDGSVGWVLSE 400
N G L F+ LLNP QVFD+ P L+L + + R+LVCGGDG+VGWVL
Sbjct: 230 TNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDA 289
Query: 401 IDKLNLNKQ----CQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDR 456
+D + + Q Q+ VLPLGTGNDL+ LGWG Y + + Q+L + A LDR
Sbjct: 290 VDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDR 349
Query: 457 WSIMT-----YELKLPPKASLLPGPPEASEEFYMTIYEDSVATHLTKILNSDEH---AVV 508
W + Y L+ P +EF M Y SV LN H A
Sbjct: 350 WKVQVTNKGYYNLRKP-------------KEFTMNNY-FSVGPDALMALNFHAHREKAPS 395
Query: 509 ISSAKTLCETVKDFVAKVEKTYDKTLENAVVADAVASKCSVLNEKLEQLLQALHTDSQAA 568
+ S++ L + V F D + +C LN+K+E L D +
Sbjct: 396 LFSSRILNKAVYLFYG--------------TKDCLVQECKDLNKKVE-----LELDGERV 436
Query: 569 PVLPGLSPLIV 579
LP L +IV
Sbjct: 437 -ALPSLEGIIV 446
Score = 126 bits (317), Expect = 1e-28
Identities = 72/176 (40%), Positives = 99/176 (56%), Gaps = 2/176 (1%)
Query: 771 MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQL 830
MNNYF +G DA ++L F+ RE+ P SR N Y GT++ L + K+L ++V+L
Sbjct: 370 MNNYFSVGPDALMALNFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVEL 429
Query: 831 ECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQM 890
E DG+ + LPSL+GI VLNI + GG W G D+ + DD +LEVV ++ S
Sbjct: 430 ELDGERVALPSLEGIIVLNIGYWGGGCRLWEG-MGDETYPLARHDDGLLEVVGVYGSFHC 488
Query: 891 AVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQML 946
A +V RI Q TV++ I +P+QVDGE W Q P + I HK A ML
Sbjct: 489 AQIQVKLANPFRIGQAHTVRL-ILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543
>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
Length = 752
Score = 168 bits (426), Expect = 3e-41
Identities = 109/296 (36%), Positives = 136/296 (45%), Gaps = 54/296 (18%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
G H W +PT+CN C L GV GL C CK+ H+RC R
Sbjct: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSR------------- 316
Query: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
N+P K K G R KC +D
Sbjct: 317 --------------------NIPGCVKTYSKAKRSGEFHR----KCELSTLCDGGELRD- 351
Query: 294 YHPICPLGQCKVSIIPPIALNSTDSDGFCRATFSFCVS----------PLLVFVNSKSGD 343
H + P C ++ P SDG A + PLLV VN KSG
Sbjct: 352 -HILLPTSICPITRDRP----GEKSDGCVSAKGELVMQYKIIPTPGTHPLLVLVNPKSGG 406
Query: 344 NQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDK 403
QG + LR+F LLNP QVF+L NGGP GL F+ +FR+L CGGDG+VGW+L IDK
Sbjct: 407 RQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGWILDCIDK 466
Query: 404 LNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSI 459
N K + VLPLGTGNDLAR L WGG Y+ + L +IL+ +E++ MLDRW +
Sbjct: 467 ANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDRWHL 521
Score = 146 bits (369), Expect = 1e-34
Identities = 83/196 (42%), Positives = 114/196 (58%), Gaps = 21/196 (10%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
+MNNYF IG+DA I+ F+ RE+HPEK SR KN +WY GT E + K L ++
Sbjct: 539 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 598
Query: 830 LECDGQYIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDI----------------FAA 871
LECDG + L + L+GIA+LNIPS GGTN WG K++ F
Sbjct: 599 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 658
Query: 872 PSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQ 930
D++LEVV + +M+M + +K R+AQC +V TI ++ +P+QVDGE W+Q
Sbjct: 659 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 716
Query: 931 PPGIIKIVHKNRAQML 946
P IKI HKN+A M+
Sbjct: 717 PCCTIKITHKNQAPMM 732
>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
Length = 766
Score = 164 bits (414), Expect = 6e-40
Identities = 103/303 (33%), Positives = 136/303 (44%), Gaps = 54/303 (17%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 233
G H W +PT+CN C L GV GL C CK+ H+RC R C T +
Sbjct: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKA- 328
Query: 234 GKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDL 293
G M H W+EGN S KC C K+ + C+WC+ H C+
Sbjct: 329 ------KRSGEVMQHAWVEGNS--SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE-- 378
Query: 294 YHPICPLGQCKVSIIPPIAL-------NSTDSDGFCRATFSFCVS----------PLLVF 336
+C G+ + I+ P ++ SDG A + PLLV
Sbjct: 379 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438
Query: 337 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGW 396
VN KSG QG + L F+ +FR+L CGGDG+VGW
Sbjct: 439 VNPKSGGRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGW 473
Query: 397 VLSEIDKLNLNKQCQLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDR 456
+L IDK N K + VLPLGTGNDLAR L WGG Y+ + L +IL+ +E++ MLDR
Sbjct: 474 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 532
Query: 457 WSI 459
W +
Sbjct: 533 WHL 535
Score = 146 bits (369), Expect = 1e-34
Identities = 83/196 (42%), Positives = 114/196 (58%), Gaps = 21/196 (10%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
+MNNYF IG+DA I+ F+ RE+HPEK SR KN +WY GT E + K L ++
Sbjct: 553 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 612
Query: 830 LECDGQYIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDI----------------FAA 871
LECDG + L + L+GIA+LNIPS GGTN WG K++ F
Sbjct: 613 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 672
Query: 872 PSFDDKILEVVAIFDSMQMA-VSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQ 930
D++LEVV + +M+M + +K R+AQC +V TI ++ +P+QVDGE W+Q
Sbjct: 673 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 730
Query: 931 PPGIIKIVHKNRAQML 946
P IKI HKN+A M+
Sbjct: 731 PCCTIKITHKNQAPMM 746
>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
Length = 1065
Score = 155 bits (393), Expect = 2e-37
Identities = 117/360 (32%), Positives = 158/360 (43%), Gaps = 56/360 (15%)
Query: 159 REPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLS---GVTSHGLSCEVCKFKAHK 215
+EP ++ +G H W ++ C + E+ ++ C VCK H
Sbjct: 161 KEPRATLDWSENAVNGEHLWLE-TNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHT 219
Query: 216 RCAVRATN---NCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVL 272
C + CK T + E+ + H W+ KC C K
Sbjct: 220 ACIEQLEKINFRCKPTFREGGSRSPREN----FVRHHWVHRRRQ-EGKCKQCGKGFQQKF 274
Query: 273 RLQDWK-----CLWCKTMVHT--ACKDLYH--PICPLGQCKVSIIPPIAL-------NST 316
+ C WCK H C L+H C LG I+PP + NS
Sbjct: 275 SFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSL 334
Query: 317 DSDGFCRATFSF--------------------------CVSPLLVFVNSKSGDNQGVKFL 350
+ + SF + PLLVFVN KSG NQG K L
Sbjct: 335 KASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVL 394
Query: 351 RRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQC 410
+ F LNP QVFDL GP L L++K N RIL CGGDG+VGW+LS +D+L L+ Q
Sbjct: 395 QMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQP 454
Query: 411 QLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSI-MTYELKLPPK 469
+GVLPLGTGNDLAR L WGG Y D+ + +IL ++E + LDRW++ + LPP+
Sbjct: 455 PVGVLPLGTGNDLARTLNWGGGYTDE-PVSKILCQVEDGTVVQLDRWNLHVERNPDLPPE 513
Score = 110 bits (275), Expect = 8e-24
Identities = 67/187 (35%), Positives = 99/187 (52%), Gaps = 12/187 (6%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + LQRS ++L + V+
Sbjct: 526 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVK 585
Query: 830 LECDG----QYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIF 885
+ CDG I Q I LNIP Y GT WG + F DD +EV+
Sbjct: 586 VVCDGTDLTPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVI--- 642
Query: 886 DSMQMAVSRVIKLQHH--RIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRA 943
MA +++ H R+ QCR V + + + +P+QVDGE P +I+I +N+A
Sbjct: 643 -GFTMASLAALQVGGHGERLHQCREVMLLTY--KSIPMQVDGEPCRLAPAMIRISLRNQA 699
Query: 944 QMLTRDR 950
M+ + +
Sbjct: 700 NMVQKSK 706
>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
Length = 929
Score = 152 bits (384), Expect = 2e-36
Identities = 108/334 (32%), Positives = 146/334 (43%), Gaps = 55/334 (16%)
Query: 174 GMHNWYACSHARPTFCNV----CRESLSGVTSHGLSCEVCKFKAHKRCAVRATN---NCK 226
G H W+ ++ FC V C + + C CK H C + CK
Sbjct: 96 GEHIWFE-TNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 154
Query: 227 WTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWK-----CLW 281
+ S +++ E + H W+ KC C K + C W
Sbjct: 155 PSFRESGSRNVREP---TFVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISCSW 210
Query: 282 CKTMVHT--AC---KDLYHPICPLGQCKVSIIPPIAL----------------------N 314
CK H+ +C + + P C LG +IPP +
Sbjct: 211 CKQAYHSKVSCFMLQQIEEP-CSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKR 269
Query: 315 STDSDG---------FCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDL 365
+ G R T S + PLLVFVN KSG NQG K ++ F LNP QVFDL
Sbjct: 270 KSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDL 329
Query: 366 MNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLAR 425
GGP L +++K N RIL CGGDG+VGW+LS +D+L L + +LPLGTGNDLAR
Sbjct: 330 SQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLAR 389
Query: 426 VLGWGGSYDDDTQLPQILEKLERASTKMLDRWSI 459
L WGG Y D+ + +IL +E + LDRW +
Sbjct: 390 TLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDL 422
Score = 105 bits (262), Expect = 3e-22
Identities = 65/184 (35%), Positives = 94/184 (51%), Gaps = 10/184 (5%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + L S K+L + ++
Sbjct: 447 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 506
Query: 830 LECDGQYIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAI 884
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 507 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 565
Query: 885 FDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQ 944
+M + + R+ QCR V +T + +PVQVDGE I+I +N+A
Sbjct: 566 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQAT 621
Query: 945 MLTR 948
M+ +
Sbjct: 622 MVQK 625
>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
Length = 895
Score = 152 bits (384), Expect = 2e-36
Identities = 108/334 (32%), Positives = 146/334 (43%), Gaps = 55/334 (16%)
Query: 174 GMHNWYACSHARPTFCNV----CRESLSGVTSHGLSCEVCKFKAHKRCAVRATN---NCK 226
G H W+ ++ FC V C + + C CK H C + CK
Sbjct: 62 GEHIWFE-TNVSGDFCYVGEQYCVARMLQKSVSRRKCAACKIVVHTPCIEQLEKINFRCK 120
Query: 227 WTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWK-----CLW 281
+ S +++ E + H W+ KC C K + C W
Sbjct: 121 PSFRESGSRNVREP---TFVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISCSW 176
Query: 282 CKTMVHT--AC---KDLYHPICPLGQCKVSIIPPIAL----------------------N 314
CK H+ +C + + P C LG +IPP +
Sbjct: 177 CKQAYHSKVSCFMLQQIEEP-CSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKR 235
Query: 315 STDSDG---------FCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDL 365
+ G R T S + PLLVFVN KSG NQG K ++ F LNP QVFDL
Sbjct: 236 KSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDL 295
Query: 366 MNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLAR 425
GGP L +++K N RIL CGGDG+VGW+LS +D+L L + +LPLGTGNDLAR
Sbjct: 296 SQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLAR 355
Query: 426 VLGWGGSYDDDTQLPQILEKLERASTKMLDRWSI 459
L WGG Y D+ + +IL +E + LDRW +
Sbjct: 356 TLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDL 388
Score = 105 bits (262), Expect = 3e-22
Identities = 65/184 (35%), Positives = 94/184 (51%), Gaps = 10/184 (5%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + L S K+L + ++
Sbjct: 413 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 472
Query: 830 LECDGQYIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAI 884
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 473 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 531
Query: 885 FDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQ 944
+M + + R+ QCR V +T + +PVQVDGE I+I +N+A
Sbjct: 532 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQAT 587
Query: 945 MLTR 948
M+ +
Sbjct: 588 MVQK 591
>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
Length = 1117
Score = 152 bits (383), Expect = 2e-36
Identities = 108/333 (32%), Positives = 146/333 (43%), Gaps = 54/333 (16%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLS---CEVCKFKAHKRCAVRATN---NCKW 227
G H W+ ++ FC V + +S C CK H C + CK
Sbjct: 285 GEHIWFE-TNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKP 343
Query: 228 TTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWK-----CLWC 282
+ S +++ E + H W+ KC C K + C WC
Sbjct: 344 SFRESGSRNVREP---TFVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISCSWC 399
Query: 283 KTMVHT--AC---KDLYHPICPLGQCKVSIIPPIAL----------------------NS 315
K H+ +C + + P C LG +IPP +
Sbjct: 400 KQAYHSKVSCFMLQQIEEP-CSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRK 458
Query: 316 TDSDG---------FCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLM 366
+ G R T S + PLLVFVN KSG NQG K ++ F LNP QVFDL
Sbjct: 459 SSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLS 518
Query: 367 NGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARV 426
GGP L +++K N RIL CGGDG+VGW+LS +D+L L + +LPLGTGNDLAR
Sbjct: 519 QGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLART 578
Query: 427 LGWGGSYDDDTQLPQILEKLERASTKMLDRWSI 459
L WGG Y D+ + +IL +E + LDRW +
Sbjct: 579 LNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDL 610
Score = 105 bits (262), Expect = 3e-22
Identities = 65/184 (35%), Positives = 94/184 (51%), Gaps = 10/184 (5%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + L S K+L + ++
Sbjct: 635 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 694
Query: 830 LECDGQYIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAI 884
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 695 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 753
Query: 885 FDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQ 944
+M + + R+ QCR V +T + +PVQVDGE I+I +N+A
Sbjct: 754 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQAT 809
Query: 945 MLTR 948
M+ +
Sbjct: 810 MVQK 813
>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
Length = 945
Score = 152 bits (383), Expect = 2e-36
Identities = 108/333 (32%), Positives = 146/333 (43%), Gaps = 54/333 (16%)
Query: 174 GMHNWYACSHARPTFCNVCRESLSGVTSHGLS---CEVCKFKAHKRCAVRATN---NCKW 227
G H W+ ++ FC V + +S C CK H C + CK
Sbjct: 113 GEHIWFE-TNVSGDFCYVGEQYCVARMLKSVSRRKCAACKIVVHTPCIEQLEKINFRCKP 171
Query: 228 TTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWK-----CLWC 282
+ S +++ E + H W+ KC C K + C WC
Sbjct: 172 SFRESGSRNVREP---TFVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISCSWC 227
Query: 283 KTMVHT--AC---KDLYHPICPLGQCKVSIIPPIAL----------------------NS 315
K H+ +C + + P C LG +IPP +
Sbjct: 228 KQAYHSKVSCFMLQQIEEP-CSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRK 286
Query: 316 TDSDG---------FCRATFSFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLM 366
+ G R T S + PLLVFVN KSG NQG K ++ F LNP QVFDL
Sbjct: 287 SSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLS 346
Query: 367 NGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGNDLARV 426
GGP L +++K N RIL CGGDG+VGW+LS +D+L L + +LPLGTGNDLAR
Sbjct: 347 QGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLART 406
Query: 427 LGWGGSYDDDTQLPQILEKLERASTKMLDRWSI 459
L WGG Y D+ + +IL +E + LDRW +
Sbjct: 407 LNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDL 438
Score = 105 bits (262), Expect = 3e-22
Identities = 65/184 (35%), Positives = 94/184 (51%), Gaps = 10/184 (5%)
Query: 770 VMNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQ 829
V NNYF +G DA ++LEF+ RE +PEK SR +N M+Y + L S K+L + ++
Sbjct: 463 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 522
Query: 830 LECDGQYIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAI 884
+ CDG + P +Q + LNIP Y GT WG E F DD LEV+
Sbjct: 523 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 581
Query: 885 FDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQ 944
+M + + R+ QCR V +T + +PVQVDGE I+I +N+A
Sbjct: 582 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQAT 637
Query: 945 MLTR 948
M+ +
Sbjct: 638 MVQK 641
>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
Length = 942
Score = 131 bits (330), Expect = 3e-30
Identities = 66/132 (50%), Positives = 85/132 (64%), Gaps = 4/132 (3%)
Query: 332 PLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDNFRILVCGGD 391
PLLVFVN KSG +G L F++LLNP QVFDL NGGP GL LF + FR+LVCGGD
Sbjct: 588 PLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGD 647
Query: 392 GSVGWVLSEIDKLNLNKQC---QLGVLPLGTGNDLARVLGWGGSYDDDTQLPQILEKLER 448
G+VGWVL +++ C + +LPLGTGNDL RVL WG Y + +L ++
Sbjct: 648 GTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPF-SVLLSVDE 706
Query: 449 ASTKMLDRWSIM 460
A ++DRW+I+
Sbjct: 707 ADAVLMDRWTIL 718
Score = 112 bits (281), Expect = 2e-24
Identities = 66/175 (37%), Positives = 101/175 (57%), Gaps = 6/175 (3%)
Query: 760 DSVDGYSEKCV-MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQ 818
D+ D K V M+NY GIG+DA++SL+F+ REE P K SR N Y +G +++
Sbjct: 730 DTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQKISH 789
Query: 819 RSYKNLEQRVQLECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKI 878
++L ++++L+ + Q + LPS++G+ +NIPS+ G + W G+ D F P DD +
Sbjct: 790 S--RSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLW-GSDSDTRFEKPRMDDGL 846
Query: 879 LEVVAIFDSMQMAVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPG 933
LEVV + + M + RIAQ ++T+ + PVQVDGE WVQ PG
Sbjct: 847 LEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLL--KATPVQVDGEPWVQAPG 899
Score = 85.9 bits (211), Expect = 2e-16
Identities = 45/123 (36%), Positives = 59/123 (47%), Gaps = 10/123 (8%)
Query: 188 FCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMP 247
FC VCR+ L H CEVC+ H C A ++C+ +D +D D
Sbjct: 134 FCAVCRKVLEAPALH---CEVCELHLHPDCVPFACSDCR-----QCHQDGHQDHD--THH 183
Query: 248 HQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQCKVSI 307
H W EGNLP A+C VC KTCGS L +C WC H+ C P C G+ + +
Sbjct: 184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLRSLV 243
Query: 308 IPP 310
+PP
Sbjct: 244 LPP 246
Score = 45.8 bits (107), Expect = 2e-04
Identities = 30/115 (26%), Positives = 50/115 (43%), Gaps = 15/115 (13%)
Query: 176 HNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGK 235
H++ + +PTFC++C + + G+ G C+VC F +H++C C S+
Sbjct: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-----TSVAP 113
Query: 236 DIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTAC 290
++ V + H + L CAVC K VL C C+ +H C
Sbjct: 114 SLVR----VPVAHCFGPRGLHKRKFCAVCRK----VLEAPALHCEVCELHLHPDC 160
>gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1
[Homo sapiens]
Length = 1849
Score = 68.6 bits (166), Expect = 4e-11
Identities = 30/81 (37%), Positives = 53/81 (65%)
Query: 1131 PKFKKEKVQKQKTSSQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLHLERRDL 1190
P ++ + + +++PV W +VA WL+ LNLGE+K+ F+ ++I G+ L +L++ DL
Sbjct: 1766 PSILQQPISNKPFTTKPVHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDL 1825
Query: 1191 KDLGIPKVGHVKRILQGIKEL 1211
DLG+ +VGH I + +K+L
Sbjct: 1826 IDLGVTRVGHRMNIERALKQL 1846
>gi|47157325 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 65.5 bits (158), Expect = 3e-10
Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 1/132 (0%)
Query: 171 HFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTL 230
H+ H + A +PTFC+VC++ + G+ G C C HK+C + C T
Sbjct: 154 HYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAA 213
Query: 231 ASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTAC 290
S ++ + MPH++ N C C +++ Q KC C VH C
Sbjct: 214 NSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVK-QGLKCEDCGMNVHHKC 272
Query: 291 KDLYHPICPLGQ 302
++ +C + Q
Sbjct: 273 REKVANLCGINQ 284
>gi|31377782 protein kinase C, delta [Homo sapiens]
Length = 676
Score = 65.5 bits (158), Expect = 3e-10
Identities = 34/132 (25%), Positives = 56/132 (42%), Gaps = 1/132 (0%)
Query: 171 HFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTL 230
H+ H + A +PTFC+VC++ + G+ G C C HK+C + C T
Sbjct: 154 HYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAA 213
Query: 231 ASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTAC 290
S ++ + MPH++ N C C +++ Q KC C VH C
Sbjct: 214 NSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVK-QGLKCEDCGMNVHHKC 272
Query: 291 KDLYHPICPLGQ 302
++ +C + Q
Sbjct: 273 REKVANLCGINQ 284
>gi|28557781 protein kinase C, eta [Homo sapiens]
Length = 683
Score = 64.7 bits (156), Expect = 5e-10
Identities = 42/143 (29%), Positives = 61/143 (42%), Gaps = 4/143 (2%)
Query: 158 TREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGV-TSHGLSCEVCKFKAHKR 216
TR+ + V +G H + A +PT+C+ CRE + GV G C+VC HKR
Sbjct: 155 TRKRQRAMRRRVHQING-HKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKR 213
Query: 217 CAVRATNNCK-WTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQ 275
C C + + I E G+ +PH++ N V C C ++R Q
Sbjct: 214 CHHLIVTACTCQNNINKVDSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMR-Q 272
Query: 276 DWKCLWCKTMVHTACKDLYHPIC 298
+C CK VH C+ P C
Sbjct: 273 GLQCKICKMNVHIRCQANVAPNC 295
>gi|5453976 protein kinase C, theta [Homo sapiens]
Length = 706
Score = 63.9 bits (154), Expect = 9e-10
Identities = 53/223 (23%), Positives = 88/223 (39%), Gaps = 13/223 (5%)
Query: 90 RGRTLYYAKDSKSL-IFDEVDLSDASVAEASTKNANNS--FTIITPFRRLMLCAENRKEM 146
+GR + K++ + E + S+AE KN + + + P R+++ A EM
Sbjct: 66 KGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNARYFLEM 125
Query: 147 EDWISSLKSVQTREPYE-------VAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGV 199
D + +T + + Q V H H + A +PTFC+VC E + G+
Sbjct: 126 SD-TKDMNEFETEGFFALHQRRGAIKQAKVHHVK-CHEFTATFFPQPTFCSVCHEFVWGL 183
Query: 200 TSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDGVAMPHQWLEGNLPVSA 259
G C C HK+C + C + + S ++ + MPH++ N
Sbjct: 184 NKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYKSPT 243
Query: 260 KCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQ 302
C C + R Q KC C VH C+ +C + Q
Sbjct: 244 FCEHCGTLLWGLAR-QGLKCDACGMNVHHRCQTKVANLCGINQ 285
>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
Length = 721
Score = 63.2 bits (152), Expect = 1e-09
Identities = 29/75 (38%), Positives = 39/75 (52%)
Query: 151 SSLKSVQTREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCK 210
SS S T P E+ + + H + S+ RPT C C++ L G+ GL C+ CK
Sbjct: 83 SSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCK 142
Query: 211 FKAHKRCAVRATNNC 225
F HKRCA R N+C
Sbjct: 143 FNCHKRCATRVPNDC 157
Score = 35.0 bits (79), Expect = 0.44
Identities = 14/30 (46%), Positives = 16/30 (53%)
Query: 196 LSGVTSHGLSCEVCKFKAHKRCAVRATNNC 225
L G+ GL C+ C HKRCA NNC
Sbjct: 2 LFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 31
>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 63.2 bits (152), Expect = 1e-09
Identities = 29/75 (38%), Positives = 39/75 (52%)
Query: 151 SSLKSVQTREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCK 210
SS S T P E+ + + H + S+ RPT C C++ L G+ GL C+ CK
Sbjct: 240 SSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCK 299
Query: 211 FKAHKRCAVRATNNC 225
F HKRCA R N+C
Sbjct: 300 FNCHKRCATRVPNDC 314
Score = 48.5 bits (114), Expect = 4e-05
Identities = 20/44 (45%), Positives = 24/44 (54%)
Query: 182 SHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNC 225
S+ P FC+ C E L G+ GL C+ C HKRCA NNC
Sbjct: 145 SYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 188
>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 63.2 bits (152), Expect = 1e-09
Identities = 29/75 (38%), Positives = 39/75 (52%)
Query: 151 SSLKSVQTREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCK 210
SS S T P E+ + + H + S+ RPT C C++ L G+ GL C+ CK
Sbjct: 240 SSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCK 299
Query: 211 FKAHKRCAVRATNNC 225
F HKRCA R N+C
Sbjct: 300 FNCHKRCATRVPNDC 314
Score = 48.5 bits (114), Expect = 4e-05
Identities = 20/44 (45%), Positives = 24/44 (54%)
Query: 182 SHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNC 225
S+ P FC+ C E L G+ GL C+ C HKRCA NNC
Sbjct: 145 SYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 188
>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
Length = 878
Score = 63.2 bits (152), Expect = 1e-09
Identities = 29/75 (38%), Positives = 39/75 (52%)
Query: 151 SSLKSVQTREPYEVAQFNVEHFSGMHNWYACSHARPTFCNVCRESLSGVTSHGLSCEVCK 210
SS S T P E+ + + H + S+ RPT C C++ L G+ GL C+ CK
Sbjct: 240 SSSASSYTGRPIELDKMLLSKVKVPHTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCK 299
Query: 211 FKAHKRCAVRATNNC 225
F HKRCA R N+C
Sbjct: 300 FNCHKRCATRVPNDC 314
Score = 48.5 bits (114), Expect = 4e-05
Identities = 20/44 (45%), Positives = 24/44 (54%)
Query: 182 SHARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNC 225
S+ P FC+ C E L G+ GL C+ C HKRCA NNC
Sbjct: 145 SYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 188
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,283,024
Number of Sequences: 37866
Number of extensions: 2241124
Number of successful extensions: 12097
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 134
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 11074
Number of HSP's gapped (non-prelim): 1007
length of query: 1220
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1106
effective length of database: 13,930,794
effective search space: 15407458164
effective search space used: 15407458164
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.