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Search of human proteins with 28827774
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 4 [Homo sapiens]
(520 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 1059 0.0
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 437 e-122
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 437 e-122
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 417 e-117
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 417 e-117
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 290 2e-78
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 290 3e-78
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 290 3e-78
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 283 2e-76
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 283 2e-76
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 283 3e-76
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 281 1e-75
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 281 1e-75
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 207 1e-53
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 207 1e-53
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 205 7e-53
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 205 7e-53
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 204 2e-52
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 204 2e-52
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 204 2e-52
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 204 2e-52
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 203 3e-52
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 203 3e-52
gi|47717134 CDC-like kinase 2 [Homo sapiens] 198 9e-51
gi|10190706 CDC-like kinase 4 [Homo sapiens] 198 1e-50
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 192 6e-49
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 166 6e-41
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 149 6e-36
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 149 6e-36
gi|11496279 male germ cell-associated kinase [Homo sapiens] 141 2e-33
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 1059 bits (2738), Expect = 0.0
Identities = 520/520 (100%), Positives = 520/520 (100%)
Query: 1 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY 60
MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY
Sbjct: 1 MPASELKASEIPFHPSIKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGY 60
Query: 61 AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK 120
AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK
Sbjct: 61 AELWFLGLEAKKLDTAPEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAK 120
Query: 121 CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC 180
CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC
Sbjct: 121 CLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFC 180
Query: 181 ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ 240
ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ
Sbjct: 181 ITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ 240
Query: 241 KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG 300
KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG
Sbjct: 241 KGQASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG 300
Query: 301 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK 360
YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK
Sbjct: 301 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSK 360
Query: 361 DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS 420
DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS
Sbjct: 361 DLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNS 420
Query: 421 FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP 480
FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP
Sbjct: 421 FFPSETRKDKVQGCHHSSRKADEITKETTEKTKDSPTKHVQHSGDQQDCLQHGADTVQLP 480
Query: 481 QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV 520
QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV
Sbjct: 481 QLVDAPKKSEAAVGAEVSMTSPGQSKNFSLKNTNVLPPIV 520
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 437 bits (1124), Expect = e-122
Identities = 219/414 (52%), Positives = 290/414 (70%), Gaps = 22/414 (5%)
Query: 23 KAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSK 82
K+ E K + +T +A+K + +L+ +E EI Y E++FLGL AKK +
Sbjct: 141 KSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNN 200
Query: 83 TSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFH 142
+DD+ G Y++V HDH+AYRYEVL+ IGKGSFGQV K DHK ++ VALK++RN+KRFH
Sbjct: 201 GGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFH 260
Query: 143 QQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGF 202
+QA E++ILE LRK+DKDNT NV+HM + F FRNH C+TFELL +NLYEL+K N FQGF
Sbjct: 261 RQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGF 320
Query: 203 SLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVY 262
SL +VR+F S+L+CL L +IIHCDLKPENI+L Q+G++ +KVIDFGSSCYEHQ+VY
Sbjct: 321 SLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVY 380
Query: 263 TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGL 322
TYIQSRFYR+PEVILG Y + IDMWSLGCI AEL TGYPL PGE+E +QLAC++E+LG+
Sbjct: 381 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 440
Query: 323 PPAGFIQTASRRQTFFDSKGFPKNIT---------------NNRGKKR-YPDSKDLTMVL 366
P + + R + F SKG+P+ T + RGK R P+S++ L
Sbjct: 441 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNAL 500
Query: 367 KTYDTS-FLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSN 419
K D FLDFL++CL W+P++RMTP QAL+H W+ + P+P T K++
Sbjct: 501 KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR-----RRLPKPPTGEKTS 549
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 437 bits (1124), Expect = e-122
Identities = 219/414 (52%), Positives = 290/414 (70%), Gaps = 22/414 (5%)
Query: 23 KAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSK 82
K+ E K + +T +A+K + +L+ +E EI Y E++FLGL AKK +
Sbjct: 68 KSMEGMGKVKATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLGLNAKKRQGMTGGPNN 127
Query: 83 TSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFH 142
+DD+ G Y++V HDH+AYRYEVL+ IGKGSFGQV K DHK ++ VALK++RN+KRFH
Sbjct: 128 GGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVALKMVRNEKRFH 187
Query: 143 QQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGF 202
+QA E++ILE LRK+DKDNT NV+HM + F FRNH C+TFELL +NLYEL+K N FQGF
Sbjct: 188 RQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGF 247
Query: 203 SLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVY 262
SL +VR+F S+L+CL L +IIHCDLKPENI+L Q+G++ +KVIDFGSSCYEHQ+VY
Sbjct: 248 SLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVY 307
Query: 263 TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGL 322
TYIQSRFYR+PEVILG Y + IDMWSLGCI AEL TGYPL PGE+E +QLAC++E+LG+
Sbjct: 308 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGM 367
Query: 323 PPAGFIQTASRRQTFFDSKGFPKNIT---------------NNRGKKR-YPDSKDLTMVL 366
P + + R + F SKG+P+ T + RGK R P+S++ L
Sbjct: 368 PSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNAL 427
Query: 367 KTYDTS-FLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSN 419
K D FLDFL++CL W+P++RMTP QAL+H W+ + P+P T K++
Sbjct: 428 KGCDDPLFLDFLKQCLEWDPAVRMTPGQALRHPWLR-----RRLPKPPTGEKTS 476
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 417 bits (1073), Expect = e-117
Identities = 216/415 (52%), Positives = 283/415 (68%), Gaps = 24/415 (5%)
Query: 17 IKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTA 76
+ T + K+PK V LT +ALK +K+ L+ YE+ EI+ Y E++F+G AKK
Sbjct: 104 LNTVKSNSSSKAPKV--VPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGV 161
Query: 77 PEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIR 136
+ +DD G Y+ V DH+AYRYEVL+ IGKGSFGQVA+ DHK + VALK++R
Sbjct: 162 IGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR 221
Query: 137 NKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKN 196
N+KRFH+QA E++ILE L+K+DK + NV+HM + F FRNH C+ FELL I+LYEL+K
Sbjct: 222 NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK 281
Query: 197 NNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256
N FQGFS+ +VR+F S+L+ L L KIIHCDLKPENI+L G++S KVIDFGSSC+
Sbjct: 282 NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF 341
Query: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316
E+QK+YTYIQSRFYR+PE+ILG Y ID+WS GCI AEL TG PLFPGE+E +QLAC+
Sbjct: 342 EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 401
Query: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNIT---------------NNRGKKR-YPDSK 360
ME+LG+PP ++ + R + F +SKG P+ + + RGKKR P SK
Sbjct: 402 MELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSK 461
Query: 361 DLTMVLKTYDT-SFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQT 414
D LK D F++FL+RCL W+PS R+TP QAL+H WI +S PRP T
Sbjct: 462 DWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKS-----VPRPLT 511
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 417 bits (1073), Expect = e-117
Identities = 216/415 (52%), Positives = 283/415 (68%), Gaps = 24/415 (5%)
Query: 17 IKTQDPKAEEKSPKKQKVTLTAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTA 76
+ T + K+PK V LT +ALK +K+ L+ YE+ EI+ Y E++F+G AKK
Sbjct: 124 LNTVKSNSSSKAPKV--VPLTPEQALKQYKHHLTAYEKLEIINYPEIYFVGPNAKKRHGV 181
Query: 77 PEKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIR 136
+ +DD G Y+ V DH+AYRYEVL+ IGKGSFGQVA+ DHK + VALK++R
Sbjct: 182 IGGPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVR 241
Query: 137 NKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKN 196
N+KRFH+QA E++ILE L+K+DK + NV+HM + F FRNH C+ FELL I+LYEL+K
Sbjct: 242 NEKRFHRQAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKK 301
Query: 197 NNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256
N FQGFS+ +VR+F S+L+ L L KIIHCDLKPENI+L G++S KVIDFGSSC+
Sbjct: 302 NKFQGFSVQLVRKFAQSILQSLDALHKNKIIHCDLKPENILLKHHGRSSTKVIDFGSSCF 361
Query: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316
E+QK+YTYIQSRFYR+PE+ILG Y ID+WS GCI AEL TG PLFPGE+E +QLAC+
Sbjct: 362 EYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACM 421
Query: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNIT---------------NNRGKKR-YPDSK 360
ME+LG+PP ++ + R + F +SKG P+ + + RGKKR P SK
Sbjct: 422 MELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRGKKRGPPGSK 481
Query: 361 DLTMVLKTYDT-SFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQT 414
D LK D F++FL+RCL W+PS R+TP QAL+H WI +S PRP T
Sbjct: 482 DWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKS-----VPRPLT 531
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 290 bits (743), Expect = 2e-78
Identities = 162/399 (40%), Positives = 238/399 (59%), Gaps = 19/399 (4%)
Query: 37 TAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKT---SFDDEHGFYL 93
T+A KL + + Y+ + YA+ +A D++ +K K +DD++ Y+
Sbjct: 41 TSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYI 100
Query: 94 KVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILE 153
+ RYE+ IGKGSFGQV K DH+ ELVA+KII+NKK F QA +EL++LE
Sbjct: 101 VRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE 160
Query: 154 ALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLS 213
+ + D + Y +VH+K F FRNH C+ FELL NLY+L++N +F+G SL++ R+
Sbjct: 161 LMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQ 220
Query: 214 VLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYR 271
+ L L+ + IIHCDLKPENI+L ++++K++DFGSSC Q++Y YIQSRFYR
Sbjct: 221 LCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYR 280
Query: 272 SPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTA 331
SPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I+EVLG+PPA + A
Sbjct: 281 SPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQA 340
Query: 332 SRRQTFFD---SKGFPKNITNN-RGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSL 387
+ + +F+ G+ T R + P ++ L D + R L +EP+
Sbjct: 341 PKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQE----------DLVLRMLEYEPAA 390
Query: 388 RMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSET 426
R++P AL+H + ++ + P S S P +T
Sbjct: 391 RISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDT 429
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 290 bits (741), Expect = 3e-78
Identities = 165/417 (39%), Positives = 241/417 (57%), Gaps = 27/417 (6%)
Query: 37 TAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKT---SFDDEHGFYL 93
T+A KL + + Y+ + YA+ +A D++ +K K +DD++ Y+
Sbjct: 41 TSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYI 100
Query: 94 KVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILE 153
+ RYE+ IGKGSFGQV K DH+ ELVA+KII+NKK F QA +EL++LE
Sbjct: 101 VRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE 160
Query: 154 ALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLS 213
+ + D + Y +VH+K F FRNH C+ FELL NLY+L++N +F+G SL++ R+
Sbjct: 161 LMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQ 220
Query: 214 VLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYR 271
+ L L+ + IIHCDLKPENI+L ++++K++DFGSSC Q++Y YIQSRFYR
Sbjct: 221 LCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYR 280
Query: 272 SPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTA 331
SPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I+EVLG+PPA + A
Sbjct: 281 SPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQA 340
Query: 332 SRRQTFFD---SKGFPKNITNN-RGKKRYPDSKDLTMVLKTYD----------------- 370
+ + +F+ G+ T R + P ++ L VL
Sbjct: 341 PKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPAD 400
Query: 371 -TSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSET 426
F D + R L +EP+ R++P AL+H + ++ + P S S P +T
Sbjct: 401 YLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDT 457
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 290 bits (741), Expect = 3e-78
Identities = 160/395 (40%), Positives = 233/395 (58%), Gaps = 23/395 (5%)
Query: 37 TAAEALKLFKNQLSPYEQSEILGYAELWFLGLEAKKLDTAPEKFSKT---SFDDEHGFYL 93
T+A KL + + Y+ + YA+ +A D++ +K K +DD++ Y+
Sbjct: 41 TSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYI 100
Query: 94 KVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILE 153
+ RYE+ IGKGSFGQV K DH+ ELVA+KII+NKK F QA +EL++LE
Sbjct: 101 VRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLE 160
Query: 154 ALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLS 213
+ + D + Y +VH+K F FRNH C+ FELL NLY+L++N +F+G SL++ R+
Sbjct: 161 LMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQ 220
Query: 214 VLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQKVYTYIQSRFYR 271
+ L L+ + IIHCDLKPENI+L ++++K++DFGSSC Q++Y YIQSRFYR
Sbjct: 221 LCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYR 280
Query: 272 SPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTA 331
SPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I+EVLG+PPA + A
Sbjct: 281 SPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQA 340
Query: 332 SRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTP 391
+ + +F+ R P L+ D + R L +EP+ R++P
Sbjct: 341 PKARKYFE---------------RLPGG---GWTLRRTKELRKDLVLRMLEYEPAARISP 382
Query: 392 DQALKHAWIHQSRNLKPQPRPQTLRKSNSFFPSET 426
AL+H + ++ + P S S P +T
Sbjct: 383 LGALQHGFFRRTADEATNTGPAGSSASTSPAPLDT 417
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 283 bits (725), Expect = 2e-76
Identities = 166/436 (38%), Positives = 236/436 (54%), Gaps = 45/436 (10%)
Query: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNK 138
K +DD++ Y+ + RYE+ IGKGSFGQV K D E VA+KII+NK
Sbjct: 125 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK 184
Query: 139 KRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNN 198
K F QA +E+++LE + K D + Y +VH+K F FRNH C+ FE+L NLY+L++N N
Sbjct: 185 KAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN 244
Query: 199 FQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256
F+G SL++ R+F + L L+ + IIHCDLKPENI+L ++++K++DFGSSC
Sbjct: 245 FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ 304
Query: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316
Q++Y YIQSRFYRSPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I
Sbjct: 305 LGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 364
Query: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNR----GKKRY--PDSKDLTMVLKTYD 370
+EVLG+PPA + A + + FF+ P N + GK+ Y P ++ L +L
Sbjct: 365 VEVLGIPPAHILDQAPKARKFFEK--LPDGTWNLKKTKDGKREYKPPGTRKLHNILGVET 422
Query: 371 ------------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRP 412
F D + R L ++P R+ P AL+H++ ++ +
Sbjct: 423 GGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD------- 475
Query: 413 QTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTE---KTKDSPTKHVQHSG----- 464
+ SNS S + SS + T + + PT +HSG
Sbjct: 476 EGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTA 535
Query: 465 --DQQDCLQHGADTVQ 478
DC H Q
Sbjct: 536 AVQAMDCETHSPQVRQ 551
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 283 bits (725), Expect = 2e-76
Identities = 166/436 (38%), Positives = 236/436 (54%), Gaps = 45/436 (10%)
Query: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNK 138
K +DD++ Y+ + RYE+ IGKGSFGQV K D E VA+KII+NK
Sbjct: 134 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK 193
Query: 139 KRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNN 198
K F QA +E+++LE + K D + Y +VH+K F FRNH C+ FE+L NLY+L++N N
Sbjct: 194 KAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN 253
Query: 199 FQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256
F+G SL++ R+F + L L+ + IIHCDLKPENI+L ++++K++DFGSSC
Sbjct: 254 FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ 313
Query: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316
Q++Y YIQSRFYRSPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I
Sbjct: 314 LGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 373
Query: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNR----GKKRY--PDSKDLTMVLKTYD 370
+EVLG+PPA + A + + FF+ P N + GK+ Y P ++ L +L
Sbjct: 374 VEVLGIPPAHILDQAPKARKFFEK--LPDGTWNLKKTKDGKREYKPPGTRKLHNILGVET 431
Query: 371 ------------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRP 412
F D + R L ++P R+ P AL+H++ ++ +
Sbjct: 432 GGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD------- 484
Query: 413 QTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTE---KTKDSPTKHVQHSG----- 464
+ SNS S + SS + T + + PT +HSG
Sbjct: 485 EGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSGGHFTA 544
Query: 465 --DQQDCLQHGADTVQ 478
DC H Q
Sbjct: 545 AVQAMDCETHSPQVRQ 560
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 283 bits (724), Expect = 3e-76
Identities = 162/415 (39%), Positives = 232/415 (55%), Gaps = 38/415 (9%)
Query: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNK 138
K +DD++ Y+ + RYE+ IGKGSFGQV K D E VA+KII+NK
Sbjct: 134 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK 193
Query: 139 KRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNN 198
K F QA +E+++LE + K D + Y +VH+K F FRNH C+ FE+L NLY+L++N N
Sbjct: 194 KAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN 253
Query: 199 FQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256
F+G SL++ R+F + L L+ + IIHCDLKPENI+L ++++K++DFGSSC
Sbjct: 254 FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ 313
Query: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316
Q++Y YIQSRFYRSPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I
Sbjct: 314 LGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 373
Query: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNR----GKKRY--PDSKDLTMVLKTYD 370
+EVLG+PPA + A + + FF+ P N + GK+ Y P ++ L +L
Sbjct: 374 VEVLGIPPAHILDQAPKARKFFEK--LPDGTWNLKKTKDGKREYKPPGTRKLHNILGVET 431
Query: 371 ------------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKPQPRP 412
F D + R L ++P R+ P AL+H++ ++ +
Sbjct: 432 GGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTAD------- 484
Query: 413 QTLRKSNSFFPSETRKDKVQGCHHSSRKADEITKETTE---KTKDSPTKHVQHSG 464
+ SNS S + SS + T + + PT +HSG
Sbjct: 485 EGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSNSGRARSDPTHQHRHSG 539
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 281 bits (718), Expect = 1e-75
Identities = 150/351 (42%), Positives = 213/351 (60%), Gaps = 28/351 (7%)
Query: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNK 138
K +DD++ Y+ + RYE+ IGKGSFGQV K D E VA+KII+NK
Sbjct: 134 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK 193
Query: 139 KRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNN 198
K F QA +E+++LE + K D + Y +VH+K F FRNH C+ FE+L NLY+L++N N
Sbjct: 194 KAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN 253
Query: 199 FQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256
F+G SL++ R+F + L L+ + IIHCDLKPENI+L ++++K++DFGSSC
Sbjct: 254 FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ 313
Query: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316
Q++Y YIQSRFYRSPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I
Sbjct: 314 LGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 373
Query: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNR----GKKRY--PDSKDLTMVLKTYD 370
+EVLG+PPA + A + + FF+ P N + GK+ Y P ++ L +L
Sbjct: 374 VEVLGIPPAHILDQAPKARKFFEK--LPDGTWNLKKTKDGKREYKPPGTRKLHNILGVET 431
Query: 371 ------------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQS 403
F D + R L ++P R+ P AL+H++ ++
Sbjct: 432 GGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 281 bits (718), Expect = 1e-75
Identities = 150/351 (42%), Positives = 213/351 (60%), Gaps = 28/351 (7%)
Query: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNK 138
K +DD++ Y+ + RYE+ IGKGSFGQV K D E VA+KII+NK
Sbjct: 134 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNK 193
Query: 139 KRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNN 198
K F QA +E+++LE + K D + Y +VH+K F FRNH C+ FE+L NLY+L++N N
Sbjct: 194 KAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN 253
Query: 199 FQGFSLSIVRRFTLSVLKCLQMLSVEK--IIHCDLKPENIVLYQKGQASVKVIDFGSSCY 256
F+G SL++ R+F + L L+ + IIHCDLKPENI+L ++++K++DFGSSC
Sbjct: 254 FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQ 313
Query: 257 EHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACI 316
Q++Y YIQSRFYRSPEV+LG PYD+AIDMWSLGCI E++TG PLF G NEV+Q+ I
Sbjct: 314 LGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI 373
Query: 317 MEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNR----GKKRY--PDSKDLTMVLKTYD 370
+EVLG+PPA + A + + FF+ P N + GK+ Y P ++ L +L
Sbjct: 374 VEVLGIPPAHILDQAPKARKFFEK--LPDGTWNLKKTKDGKREYKPPGTRKLHNILGVET 431
Query: 371 ------------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQS 403
F D + R L ++P R+ P AL+H++ ++
Sbjct: 432 GGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKT 482
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 207 bits (528), Expect = 1e-53
Identities = 127/356 (35%), Positives = 184/356 (51%), Gaps = 37/356 (10%)
Query: 81 SKTSFDDEHGFYLKVLHD---HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137
SK S + G Y V H+ + YEVLE +G+G+FGQV KC NE+VA+KI++N
Sbjct: 173 SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN 232
Query: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
+ +Q +E+ IL L + D+ YN V + F +NH C+ FE+L NLY+ +K N
Sbjct: 233 HPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQN 291
Query: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQAS--VKVIDFGSSC 255
F L +R V L L +IH DLKPENI+L + VKVIDFGS+
Sbjct: 292 KFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSAS 351
Query: 256 YEHQKVY-TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314
+ + V TY+QSR+YR+PE+ILG P+ AIDMWSLGC+ AEL+ G+PL+PG +E +Q+
Sbjct: 352 HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIR 411
Query: 315 CIMEVLGLPPAGFIQTASRRQTFF----------------DSKGFPKNITNNRGKKR-YP 357
I + GLP + ++ FF D I + +K +
Sbjct: 412 YISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFN 471
Query: 358 DSKDLTMVLKTYD-------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400
D+ V T D F+D L++ L + R+TP + L H ++
Sbjct: 472 CLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFV 527
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 207 bits (528), Expect = 1e-53
Identities = 127/356 (35%), Positives = 184/356 (51%), Gaps = 37/356 (10%)
Query: 81 SKTSFDDEHGFYLKVLHD---HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137
SK S + G Y V H+ + YEVLE +G+G+FGQV KC NE+VA+KI++N
Sbjct: 173 SKNSGSNSEGDYQLVQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKN 232
Query: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
+ +Q +E+ IL L + D+ YN V + F +NH C+ FE+L NLY+ +K N
Sbjct: 233 HPSYARQGQIEVSILARLSTESADD-YNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQN 291
Query: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQAS--VKVIDFGSSC 255
F L +R V L L +IH DLKPENI+L + VKVIDFGS+
Sbjct: 292 KFSPLPLKYIRPVLQQVATALMKLKSLGLIHADLKPENIMLVDPSRQPYRVKVIDFGSAS 351
Query: 256 YEHQKVY-TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314
+ + V TY+QSR+YR+PE+ILG P+ AIDMWSLGC+ AEL+ G+PL+PG +E +Q+
Sbjct: 352 HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIR 411
Query: 315 CIMEVLGLPPAGFIQTASRRQTFF----------------DSKGFPKNITNNRGKKR-YP 357
I + GLP + ++ FF D I + +K +
Sbjct: 412 YISQTQGLPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFN 471
Query: 358 DSKDLTMVLKTYD-------------TSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400
D+ V T D F+D L++ L + R+TP + L H ++
Sbjct: 472 CLDDMAQVNMTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPFV 527
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 205 bits (522), Expect = 7e-53
Identities = 125/356 (35%), Positives = 188/356 (52%), Gaps = 37/356 (10%)
Query: 81 SKTSFDDEHGFYLKVLHD---HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137
+K+S G Y V H+ + YEVLE +G+G+FGQVAKC E+VA+KI++N
Sbjct: 164 TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKN 223
Query: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
+ +Q +E+ IL L ++ D YN V + F +NH C+ FE+L NLY+ +K N
Sbjct: 224 HPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQN 282
Query: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ--KGQASVKVIDFGSSC 255
F L +R V L L +IH DLKPENI+L + VKVIDFGS+
Sbjct: 283 KFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSAS 342
Query: 256 YEHQKVY-TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314
+ + V TY+QSR+YR+PE+ILG P+ AIDMWSLGC+ AEL+ G+PL+PG +E +Q+
Sbjct: 343 HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIR 402
Query: 315 CIMEVLGLPPAGFIQTASRRQTFFD---SKGFP-------------KNITNNRGKK---- 354
I + GLP + ++ FF+ + G+P I + +K
Sbjct: 403 YISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFN 462
Query: 355 ---------RYPDSKDLTMVLKTYD-TSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400
D + M+ + D ++D L++ L + R+TP + L H ++
Sbjct: 463 CLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV 518
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 205 bits (522), Expect = 7e-53
Identities = 125/356 (35%), Positives = 188/356 (52%), Gaps = 37/356 (10%)
Query: 81 SKTSFDDEHGFYLKVLHD---HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137
+K+S G Y V H+ + YEVLE +G+G+FGQVAKC E+VA+KI++N
Sbjct: 164 TKSSSSSGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKN 223
Query: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
+ +Q +E+ IL L ++ D YN V + F +NH C+ FE+L NLY+ +K N
Sbjct: 224 HPSYARQGQIEVSILSRLSSENADE-YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQN 282
Query: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ--KGQASVKVIDFGSSC 255
F L +R V L L +IH DLKPENI+L + VKVIDFGS+
Sbjct: 283 KFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSAS 342
Query: 256 YEHQKV-YTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314
+ + V TY+QSR+YR+PE+ILG P+ AIDMWSLGC+ AEL+ G+PL+PG +E +Q+
Sbjct: 343 HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIR 402
Query: 315 CIMEVLGLPPAGFIQTASRRQTFFD---SKGFP-------------KNITNNRGKK---- 354
I + GLP + ++ FF+ + G+P I + +K
Sbjct: 403 YISQTQGLPAEYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFN 462
Query: 355 ---------RYPDSKDLTMVLKTYD-TSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400
D + M+ + D ++D L++ L + R+TP + L H ++
Sbjct: 463 CLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQFV 518
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 204 bits (518), Expect = 2e-52
Identities = 121/359 (33%), Positives = 193/359 (53%), Gaps = 32/359 (8%)
Query: 78 EKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDH-KNNELVALKIIR 136
++ S++ DD+ G + + D + RYE++ +G+G+FG+V +CLDH + VALKIIR
Sbjct: 278 KRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR 337
Query: 137 NKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKN 196
N ++ + A +E+ +L+ +++KDK+N + V M D+F F H CI FELLG N +E +K
Sbjct: 338 NVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKE 397
Query: 197 NNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIV--------LYQKGQA---- 244
NNFQ + L VR + L+ L ++ H DLKPENI+ LY + ++
Sbjct: 398 NNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEK 457
Query: 245 -----SVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYT 299
S++V DFGS+ ++H+ T + +R YR PEVIL + D+WS+GCI E Y
Sbjct: 458 SVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYR 517
Query: 300 GYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDS 359
G+ LF E L + ++LG P+ I +R+Q +F G + ++ G+ +
Sbjct: 518 GFTLFQTHENREHLVMMEKILGPIPSHMIH-RTRKQKYFYKGGLVWDENSSDGRYVKENC 576
Query: 360 KDLTMVL---KTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAW----------IHQSRN 405
K L + D +RR L ++P+ R+T +AL H + H SRN
Sbjct: 577 KPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRN 635
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 204 bits (518), Expect = 2e-52
Identities = 121/359 (33%), Positives = 193/359 (53%), Gaps = 32/359 (8%)
Query: 78 EKFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDH-KNNELVALKIIR 136
++ S++ DD+ G + + D + RYE++ +G+G+FG+V +CLDH + VALKIIR
Sbjct: 130 KRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIR 189
Query: 137 NKKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKN 196
N ++ + A +E+ +L+ +++KDK+N + V M D+F F H CI FELLG N +E +K
Sbjct: 190 NVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKE 249
Query: 197 NNFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIV--------LYQKGQA---- 244
NNFQ + L VR + L+ L ++ H DLKPENI+ LY + ++
Sbjct: 250 NNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEK 309
Query: 245 -----SVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYT 299
S++V DFGS+ ++H+ T + +R YR PEVIL + D+WS+GCI E Y
Sbjct: 310 SVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYR 369
Query: 300 GYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDS 359
G+ LF E L + ++LG P+ I +R+Q +F G + ++ G+ +
Sbjct: 370 GFTLFQTHENREHLVMMEKILGPIPSHMIH-RTRKQKYFYKGGLVWDENSSDGRYVKENC 428
Query: 360 KDLTMVL---KTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAW----------IHQSRN 405
K L + D +RR L ++P+ R+T +AL H + H SRN
Sbjct: 429 KPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRN 487
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 204 bits (518), Expect = 2e-52
Identities = 128/362 (35%), Positives = 189/362 (52%), Gaps = 37/362 (10%)
Query: 81 SKTSFDDEHGFYLKVLHDHIAYR---YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137
SK + G Y V H+ + YEVL+ +G+G+FGQV KC NE+VA+KI++N
Sbjct: 171 SKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKN 230
Query: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
+ +Q +E+ IL L ++ D YN V + F RNH C+ FE+L NLY+ +K N
Sbjct: 231 HPSYARQGQIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQN 289
Query: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ--KGQASVKVIDFGSSC 255
F L ++R V L+ L +IH DLKPENI+L + VKVIDFGS+
Sbjct: 290 KFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSAS 349
Query: 256 YEHQKVY-TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314
+ + V TY+QSR+YR+PE+ILG P+ AIDMWSLGC+ AEL+ G+PL+PG E +Q+
Sbjct: 350 HVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIR 409
Query: 315 CIMEVLGLPPAGFIQTASRRQTFF-------------------------DSKGFPKNITN 349
I + GLP + ++ FF SK K I N
Sbjct: 410 YISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFN 469
Query: 350 NRGKKRYPDS-KDL----TMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSR 404
+ + ++ DL + K F+ L++ L+ + LR+TP + L H +++
Sbjct: 470 SLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKH 529
Query: 405 NL 406
L
Sbjct: 530 LL 531
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 204 bits (518), Expect = 2e-52
Identities = 128/362 (35%), Positives = 189/362 (52%), Gaps = 37/362 (10%)
Query: 81 SKTSFDDEHGFYLKVLHDHIAYR---YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRN 137
SK + G Y V H+ + YEVL+ +G+G+FGQV KC NE+VA+KI++N
Sbjct: 171 SKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKN 230
Query: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
+ +Q +E+ IL L ++ D YN V + F RNH C+ FE+L NLY+ +K N
Sbjct: 231 HPSYARQGQIEVSILARLSTENADE-YNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQN 289
Query: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQ--KGQASVKVIDFGSSC 255
F L ++R V L+ L +IH DLKPENI+L + VKVIDFGS+
Sbjct: 290 KFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSAS 349
Query: 256 YEHQKVY-TYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLA 314
+ + V TY+QSR+YR+PE+ILG P+ AIDMWSLGC+ AEL+ G+PL+PG E +Q+
Sbjct: 350 HVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIR 409
Query: 315 CIMEVLGLPPAGFIQTASRRQTFF-------------------------DSKGFPKNITN 349
I + GLP + ++ FF SK K I N
Sbjct: 410 YISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFN 469
Query: 350 NRGKKRYPDS-KDL----TMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSR 404
+ + ++ DL + K F+ L++ L+ + LR+TP + L H +++
Sbjct: 470 SLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKH 529
Query: 405 NL 406
L
Sbjct: 530 LL 531
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 203 bits (517), Expect = 3e-52
Identities = 112/339 (33%), Positives = 183/339 (53%), Gaps = 20/339 (5%)
Query: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHK-NNELVALKIIRN 137
K +++ DDE G + D ++ RYE+++T+G+G+FG+V +C+DHK VA+KI++N
Sbjct: 178 KRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN 237
Query: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
R+ + A E+++LE L D ++T+ V M ++F H CI FELLG++ Y+ +K N
Sbjct: 238 VDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKEN 297
Query: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKG--------------- 242
F F L +R+ + K + L K+ H DLKPENI+ Q
Sbjct: 298 GFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERT 357
Query: 243 --QASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG 300
+KV+DFGS+ Y+ + T + +R YR+PEVIL + D+WS+GCI E Y G
Sbjct: 358 LINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLG 417
Query: 301 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTF-FDSKGFPKNITNNR-GKKRYPD 358
+ +FP + E LA + +LG P IQ +R+ F D + ++ + R +R
Sbjct: 418 FTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKP 477
Query: 359 SKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKH 397
K+ + D +++ L ++P+ R+T +ALKH
Sbjct: 478 LKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKH 516
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 203 bits (517), Expect = 3e-52
Identities = 112/339 (33%), Positives = 183/339 (53%), Gaps = 20/339 (5%)
Query: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHK-NNELVALKIIRN 137
K +++ DDE G + D ++ RYE+++T+G+G+FG+V +C+DHK VA+KI++N
Sbjct: 136 KRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKN 195
Query: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
R+ + A E+++LE L D ++T+ V M ++F H CI FELLG++ Y+ +K N
Sbjct: 196 VDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKEN 255
Query: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKG--------------- 242
F F L +R+ + K + L K+ H DLKPENI+ Q
Sbjct: 256 GFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERT 315
Query: 243 --QASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG 300
+KV+DFGS+ Y+ + T + +R YR+PEVIL + D+WS+GCI E Y G
Sbjct: 316 LINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLG 375
Query: 301 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTF-FDSKGFPKNITNNR-GKKRYPD 358
+ +FP + E LA + +LG P IQ +R+ F D + ++ + R +R
Sbjct: 376 FTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKP 435
Query: 359 SKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKH 397
K+ + D +++ L ++P+ R+T +ALKH
Sbjct: 436 LKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKH 474
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 198 bits (504), Expect = 9e-51
Identities = 111/349 (31%), Positives = 192/349 (55%), Gaps = 22/349 (6%)
Query: 81 SKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNEL-VALKIIRNKK 139
+K+ DD G + + D + RYE++ T+G+G+FG+V +C+DH+ VALKII+N +
Sbjct: 139 AKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVE 198
Query: 140 RFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNF 199
++ + A +E+ +LE + +KD DN V M D+F + H CI+FELLG++ ++ +K+NN+
Sbjct: 199 KYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNY 258
Query: 200 QGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKG----------------- 242
+ + VR + + ++ L K+ H DLKPENI+
Sbjct: 259 LPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVK 318
Query: 243 QASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYP 302
+V+V+DFGS+ ++H+ T + +R YR+PEVIL + D+WS+GCI E Y G+
Sbjct: 319 STAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFT 378
Query: 303 LFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSK-GFPKNITNNRGKKR--YPDS 359
LF + E LA + +LG P+ I+ +++ F+ + + +N + R + P
Sbjct: 379 LFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLR 438
Query: 360 KDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKHAWIHQSRNLKP 408
+ LT + + F D + L +EP+ R+T +AL+H + + R P
Sbjct: 439 RYLTSEAEEHHQLF-DLIESMLEYEPAKRLTLGEALQHPFFARLRAEPP 486
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 198 bits (503), Expect = 1e-50
Identities = 108/339 (31%), Positives = 185/339 (54%), Gaps = 20/339 (5%)
Query: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNEL-VALKIIRN 137
K S++ DDE G + D + RYE+++T+G+G+FG+V +C+DH + + VA+KI++N
Sbjct: 134 KRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKN 193
Query: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
R+ + A E+++LE L D ++ + V M ++F H CI FELLG++ Y+ +K N
Sbjct: 194 VGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKEN 253
Query: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKG--------------- 242
+F F + +R+ + + + L K+ H DLKPENI+ +
Sbjct: 254 SFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERT 313
Query: 243 --QASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG 300
+KV+DFGS+ Y+ + T + +R YR+PEVIL + D+WS+GCI E Y G
Sbjct: 314 LKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLG 373
Query: 301 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSK-GFPKNITNNR-GKKRYPD 358
+ +F + E LA + +LG P IQ +R+ F ++ + ++ + R ++R
Sbjct: 374 FTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKP 433
Query: 359 SKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKH 397
K+ + D +RR L ++P+ R+T D+AL+H
Sbjct: 434 LKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQH 472
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 192 bits (488), Expect = 6e-49
Identities = 117/338 (34%), Positives = 174/338 (51%), Gaps = 42/338 (12%)
Query: 104 YEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQQALMELKILEALRKKDKDNT 163
Y+++E +GKG+FG+VAK E+VA+KI++N ++ ELK+L +R D +
Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGEMVAIKILKNDAYRNRIIKNELKLLHCMRGLDPEEA 70
Query: 164 YNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQMLSV 223
+ V+ +FF+ F + FELL NL+E K NNF +R TL VL L L
Sbjct: 71 H-VIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLKE 129
Query: 224 EKIIHCDLKPENIVLYQKGQAS--VKVIDFGSSCYEHQKVYT---YIQSRFYRSPEVILG 278
IIH DLKPENI+L + + VKVIDFGS+ + Y YIQSRFYR+PE++LG
Sbjct: 130 LAIIHADLKPENIMLVDQTRCPFRVKVIDFGSASIFSEVRYVKEPYIQSRFYRAPEILLG 189
Query: 279 HPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFF 338
P+ +D+WSLGC+ AEL+ G+PL+PG NE +Q+ I E GLP + A + FF
Sbjct: 190 LPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGLPKPHLLHAACKAHHFF 249
Query: 339 DSKGFP--------KNITNNRGKKRYPDSKDLTMVLKTYD-------------------- 370
P K+ + + + + +LK+ D
Sbjct: 250 KRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIETVNGGSVASRLTFPDRE 309
Query: 371 --------TSFLDFLRRCLVWEPSLRMTPDQALKHAWI 400
S ++ ++R L WE R++P AL+H ++
Sbjct: 310 ALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFV 347
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 166 bits (419), Expect = 6e-41
Identities = 106/347 (30%), Positives = 176/347 (50%), Gaps = 32/347 (9%)
Query: 82 KTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDH-KNNELVALKIIRNKKR 140
+ ++ D G+Y + + + RY V G+G F V + D+ + N+ VA+KIIRN +
Sbjct: 665 RDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNEL 724
Query: 141 FHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQ 200
+ L EL+ L+ L D D+ ++ + + FY + H C+ FE L +NL E++K
Sbjct: 725 MQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKD 784
Query: 201 -GFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSCYEHQ 259
G + VR ++ + L++L I+H D+KP+NI L + + +K+ DFGS+ +
Sbjct: 785 VGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNI-LVNESKTILKLCDFGSASHVAD 843
Query: 260 KVYT-YIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIME 318
T Y+ SRFYR+PE+I+G YD IDMWS+GC ELYTG LFPG+ L M+
Sbjct: 844 NDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMD 903
Query: 319 VLGLPPAGFIQTASRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTS------ 372
+ G P I R+ F + F +N+ + ++ V+ T + +
Sbjct: 904 LKGKMPNKMI-----RKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLAD 958
Query: 373 -----------------FLDFLRRCLVWEPSLRMTPDQALKHAWIHQ 402
D L + L+ +P+ R++ +QAL+HA+I +
Sbjct: 959 LIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQE 1005
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 149 bits (376), Expect = 6e-36
Identities = 103/357 (28%), Positives = 175/357 (49%), Gaps = 32/357 (8%)
Query: 99 HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKR---FHQQALMELKILEAL 155
++ ++E+L +G+G++G V KC + +E+VA+K ++ + + L ELK+L L
Sbjct: 8 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 67
Query: 156 RKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVL 215
+++ N+V +K+ F R + FE + N+ EL++ G V+ + ++
Sbjct: 68 KQE------NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLI 120
Query: 216 KCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSS---CYEHQKVYT-YIQSRFYR 271
K + I+H D+KPEN+++ +K+ DFG + + YT Y+ +R+YR
Sbjct: 121 KAIHWCHKNDIVHRDIKPENLLISHNDV--LKLCDFGFARNLSEGNNANYTEYVATRWYR 178
Query: 272 SPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTA 331
SPE++LG PY ++DMWS+GCI EL G PLFPGE+E++QL I +VLG P+ ++
Sbjct: 179 SPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLF 238
Query: 332 SRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTP 391
F + FP ++RY L ++ LD ++ L +P+ R
Sbjct: 239 YSNPRFHGLR-FPAVNHPQSLERRY---------LGILNSVLLDLMKNLLKLDPADRYLT 288
Query: 392 DQALKHAWIHQSRNLKPQP------RPQTLRKSNSFFPSETRKDKVQGCHHSSRKAD 442
+Q L H R L P +P + S ++ K HH S D
Sbjct: 289 EQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKD 345
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 149 bits (376), Expect = 6e-36
Identities = 103/357 (28%), Positives = 175/357 (49%), Gaps = 32/357 (8%)
Query: 99 HIAYRYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKR---FHQQALMELKILEAL 155
++ ++E+L +G+G++G V KC + +E+VA+K ++ + + L ELK+L L
Sbjct: 8 NVMNKFEILGVVGEGAYGVVLKCRHKETHEIVAIKKFKDSEENEEVKETTLRELKMLRTL 67
Query: 156 RKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVL 215
+++ N+V +K+ F R + FE + N+ EL++ G V+ + ++
Sbjct: 68 KQE------NIVELKEAFRRRGKLYLVFEYVEKNMLELLEEMP-NGVPPEKVKSYIYQLI 120
Query: 216 KCLQMLSVEKIIHCDLKPENIVLYQKGQASVKVIDFGSS---CYEHQKVYT-YIQSRFYR 271
K + I+H D+KPEN+++ +K+ DFG + + YT Y+ +R+YR
Sbjct: 121 KAIHWCHKNDIVHRDIKPENLLISHNDV--LKLCDFGFARNLSEGNNANYTEYVATRWYR 178
Query: 272 SPEVILGHPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLPPAGFIQTA 331
SPE++LG PY ++DMWS+GCI EL G PLFPGE+E++QL I +VLG P+ ++
Sbjct: 179 SPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPSEQMKLF 238
Query: 332 SRRQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTP 391
F + FP ++RY L ++ LD ++ L +P+ R
Sbjct: 239 YSNPRFHGLR-FPAVNHPQSLERRY---------LGILNSVLLDLMKNLLKLDPADRYLT 288
Query: 392 DQALKHAWIHQSRNLKPQP------RPQTLRKSNSFFPSETRKDKVQGCHHSSRKAD 442
+Q L H R L P +P + S ++ K HH S D
Sbjct: 289 EQCLNHPTFQTQRLLDRSPSRSAKRKPYHVESSTLSNRNQAGKSTALQSHHRSNSKD 345
>gi|11496279 male germ cell-associated kinase [Homo sapiens]
Length = 623
Score = 141 bits (355), Expect = 2e-33
Identities = 110/371 (29%), Positives = 179/371 (48%), Gaps = 37/371 (9%)
Query: 103 RYEVLETIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHQ-QALMELKILEALRKKDKD 161
RY + +G G++G V +++ ELVA+K R K++F+ M L+ +++L+K
Sbjct: 3 RYTTMRQLGDGTYGSVLMGKSNESGELVAIK--RMKRKFYSWDECMNLREVKSLKKL--- 57
Query: 162 NTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNNNFQGFSLSIVRRFTLSVLKCLQML 221
N NV+ +K+ +H FE + NLY+LMK+ N + F S++R +L+ L +
Sbjct: 58 NHANVIKLKEVIRENDHLYFIFEYMKENLYQLMKDRN-KLFPESVIRNIMYQILQGLAFI 116
Query: 222 SVEKIIHCDLKPENIVLYQKGQASVKVIDFGSSC-YEHQKVYT-YIQSRFYRSPEVIL-G 278
H D+KPEN++ G VK+ DFG + Q YT Y+ +R+YR+PEV+L
Sbjct: 117 HKHGFFHRDMKPENLLCM--GPELVKIADFGLARELRSQPPYTDYVSTRWYRAPEVLLRS 174
Query: 279 HPYDVAIDMWSLGCITAELYTGYPLFPGENEVEQLACIMEVLGLP-----PAGFIQTASR 333
Y ID+W++G I AELY PLFPG +EV+++ I +VLG P P G+ +S
Sbjct: 175 SVYSSPIDVWAVGSIMAELYMLRPLFPGTSEVDEIFKICQVLGTPKKSDWPEGYQLASSM 234
Query: 334 RQTFFDSKGFPKNITNNRGKKRYPDSKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQ 393
+ FP+ + N L ++ + + L W+P R T Q
Sbjct: 235 ------NFRFPQCVPIN-----------LKTLIPNASNEAIQLMTEMLNWDPKKRPTASQ 277
Query: 394 ALKHAWIHQSRNLKPQPRPQTLRKS--NSFFPSETRKDKVQ-GCHHSSRKADEITKETTE 450
ALKH + + L P ++S P E++ V+ D++ +
Sbjct: 278 ALKHPYFQVGQVLGPSSNHLESKQSLNKQLQPLESKPSLVEVEPKPLPDIIDQVVGQPQP 337
Query: 451 KTKDSPTKHVQ 461
KT P + +Q
Sbjct: 338 KTSQQPLQPIQ 348
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,267,736
Number of Sequences: 37866
Number of extensions: 921815
Number of successful extensions: 4589
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 479
Number of HSP's successfully gapped in prelim test: 249
Number of HSP's that attempted gapping in prelim test: 2691
Number of HSP's gapped (non-prelim): 1064
length of query: 520
length of database: 18,247,518
effective HSP length: 107
effective length of query: 413
effective length of database: 14,195,856
effective search space: 5862888528
effective search space used: 5862888528
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.