BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|28416927 purinergic receptor P2X4 [Homo sapiens] (388 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|28416927 purinergic receptor P2X4 [Homo sapiens] 795 0.0 gi|4505545 purinergic receptor P2X1 [Homo sapiens] 423 e-118 gi|28416933 purinergic receptor P2X5 isoform A [Homo sapiens] 370 e-102 gi|28416923 purinergic receptor P2X2 isoform B [Homo sapiens] 345 4e-95 gi|25092719 purinergic receptor P2X2 isoform A [Homo sapiens] 345 5e-95 gi|28416925 purinergic receptor P2X3 [Homo sapiens] 344 7e-95 gi|157419148 purinergic receptor P2X6 isoform 1 [Homo sapiens] 341 6e-94 gi|29294631 purinergic receptor P2X7 [Homo sapiens] 333 2e-91 gi|28416935 purinergic receptor P2X5 isoform B [Homo sapiens] 333 2e-91 gi|25092733 purinergic receptor P2X2 isoform D [Homo sapiens] 330 1e-90 gi|7706629 purinergic receptor P2X2 isoform C [Homo sapiens] 319 3e-87 gi|227116341 purinergic receptor P2X6 isoform 2 [Homo sapiens] 315 6e-86 gi|28416921 purinergic receptor P2X2 isoform H [Homo sapiens] 258 6e-69 gi|27881423 purinergic receptor P2X2 isoform I [Homo sapiens] 243 3e-64 gi|28416937 purinergic receptor P2X5 isoform C [Homo sapiens] 175 5e-44 gi|53692193 Scm-like with four mbt domains 1 [Homo sapiens] 31 2.2 gi|53692191 Scm-like with four mbt domains 1 [Homo sapiens] 31 2.2 gi|53692195 Scm-like with four mbt domains 1 [Homo sapiens] 31 2.2 gi|108860679 solute carrier family 25, member 27 [Homo sapiens] 30 4.8 gi|37577159 calcium-sensing receptor [Homo sapiens] 29 6.3 gi|11863152 jumonji, AT rich interactive domain 2 protein [Homo ... 29 6.3 >gi|28416927 purinergic receptor P2X4 [Homo sapiens] Length = 388 Score = 795 bits (2052), Expect = 0.0 Identities = 388/388 (100%), Positives = 388/388 (100%) Query: 1 MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV 60 MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV Sbjct: 1 MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV 60 Query: 61 VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP 120 VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP Sbjct: 61 VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP 120 Query: 121 DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK 180 DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK Sbjct: 121 DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK 180 Query: 181 AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG 240 AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG Sbjct: 181 AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG 240 Query: 241 HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY 300 HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY Sbjct: 241 HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY 300 Query: 301 RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC 360 RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC Sbjct: 301 RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC 360 Query: 361 MKKRLYYREKKYKYVEDYEQGLASELDQ 388 MKKRLYYREKKYKYVEDYEQGLASELDQ Sbjct: 361 MKKRLYYREKKYKYVEDYEQGLASELDQ 388 >gi|4505545 purinergic receptor P2X1 [Homo sapiens] Length = 399 Score = 423 bits (1087), Expect = e-118 Identities = 195/376 (51%), Positives = 273/376 (72%), Gaps = 5/376 (1%) Query: 8 LAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTK 67 LAAFLFEYDTPR+VL+R++KVG++ R +QL++L YVIGWVF++EKGYQ + ++SSV+ K Sbjct: 9 LAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSGLISSVSVK 68 Query: 68 VKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCK 127 +KG+AVT LG ++WDVADYV PAQ +NS VMTN I+T QTQG C E P+ +CK Sbjct: 69 LKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEHPEGG-ICK 127 Query: 128 SDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTL 187 D+ CT G A + G+ TG+CVAFN +VKTCE+ WCPVE D +P+PA L+ AENFTL Sbjct: 128 EDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLREAENFTL 187 Query: 188 LVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMA 247 +KN+I +P+F ++RN++ + ++K+C++ P CP+F+LG +V+ +G +F +A Sbjct: 188 FIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESGQNFSTLA 247 Query: 248 VEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNE 307 +GG++GI ++W C+LD C P Y F L E N+SPG+NFRFA+++ + G Sbjct: 248 EKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYE---EKNLSPGFNFRFARHFVE-NGTN 303 Query: 308 QRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYY 367 R L K +GIRFDI+V GKAGKFDIIPTM IGSG+ + G+ATVLCD+++L+ + KR YY Sbjct: 304 YRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYY 363 Query: 368 REKKYKYVEDYEQGLA 383 ++KK+KY ED G A Sbjct: 364 KQKKFKYAEDMGPGAA 379 >gi|28416933 purinergic receptor P2X5 isoform A [Homo sapiens] Length = 422 Score = 370 bits (950), Expect = e-102 Identities = 194/389 (49%), Positives = 258/389 (66%), Gaps = 32/389 (8%) Query: 5 CAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETD-SVVSS 63 C L LF+Y T + V+ +++KVGL+ R +Q ILAY++ WVF+ +KGYQ+ D S+ S+ Sbjct: 6 CKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSA 65 Query: 64 VTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPE---IP 120 V TKVKGVA TNTS LG RIWDVADYVIPAQ EN FV+TN+I+T NQ Q +C E IP Sbjct: 66 VITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIP 125 Query: 121 DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVK-TCEVAAWCPVEDDTHVPQPAFL 179 D C D+ C AG A T NGV TGRC+ + TCE+ AWCP+E + P+ FL Sbjct: 126 DG--ACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSR-PEEPFL 182 Query: 180 KAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENA 239 K AE+FT+ +KN+I +PKFNFSK N++ ++LKSC + K + +CPIFRLG ++ A Sbjct: 183 KEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPK-NHYCPIFRLGSVIRWA 241 Query: 240 GHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKY 299 G FQD+A+EGG++GI + W+C+LD+AAS C P YSF RLD + + +VS GYNFRFA+Y Sbjct: 242 GSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNK-LSKSVSSGYNFRFARY 300 Query: 300 YRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLY 359 YRD AG E RTL+KAYGIRFD++V GK F CD++++Y Sbjct: 301 YRDAAGVEFRTLMKAYGIRFDVMVNGKGAFF----------------------CDLVLIY 338 Query: 360 CMKKRLYYREKKYKYVEDYEQGLASELDQ 388 +KKR +YR+KKY+ V E D+ Sbjct: 339 LIKKREFYRDKKYEEVRGLEDSSQEAEDE 367 >gi|28416923 purinergic receptor P2X2 isoform B [Homo sapiens] Length = 404 Score = 345 bits (885), Expect = 4e-95 Identities = 185/379 (48%), Positives = 251/379 (66%), Gaps = 19/379 (5%) Query: 3 GCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDS-VV 61 GC +AL ++Y+TP+++++R+R++G++ RAVQLLIL Y + +VF+ +K YQE+++ Sbjct: 20 GCWSAL----WDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPE 75 Query: 62 SSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPE-IP 120 SS+ TKVKG+ + ++WDV +YV P + + ++T V T +QTQG CPE I Sbjct: 76 SSIITKVKGITTSE-----HKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIR 130 Query: 121 DATTVCKSDASCTAGSAGTHSNGVSTGRCVAF-NGSVKTCEVAAWCPVEDDTHVPQPAFL 179 C SDA C AG NG+ TGRCV + G KTCEV WCPVED V Q FL Sbjct: 131 VHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ--FL 188 Query: 180 KA-AENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVEN 238 A NFT+L+KN+I YPKF+FSK NI T YLK C + +D +CPIF+LG IVE Sbjct: 189 GTMAPNFTILIKNSIHYPKFHFSKGNIADR-TDGYLKRCTFHEASDLYCPIFKLGFIVEK 247 Query: 239 AGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAK 298 AG SF ++A +GG++G+ +NWDC+LD AS C P+YSFRRLD + V S GYNFRFAK Sbjct: 248 AGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVP--ASSGYNFRFAK 305 Query: 299 YYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVL 358 YY+ + G RTLIKAYGIR D+IV G+AGKF +IPT+IN+ + L +G+ + LCD I+L Sbjct: 306 YYK-INGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILL 364 Query: 359 YCMKKRLYYREKKYKYVED 377 M K Y KK+ + D Sbjct: 365 TFMNKNKVYSHKKFDKMVD 383 >gi|25092719 purinergic receptor P2X2 isoform A [Homo sapiens] Length = 471 Score = 345 bits (884), Expect = 5e-95 Identities = 185/377 (49%), Positives = 250/377 (66%), Gaps = 19/377 (5%) Query: 3 GCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDS-VV 61 GC +AL ++Y+TP+++++R+R++G++ RAVQLLIL Y + +VF+ +K YQE+++ Sbjct: 20 GCWSAL----WDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPE 75 Query: 62 SSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPE-IP 120 SS+ TKVKG+ + ++WDV +YV P + + ++T V T +QTQG CPE I Sbjct: 76 SSIITKVKGITTSE-----HKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIR 130 Query: 121 DATTVCKSDASCTAGSAGTHSNGVSTGRCVAF-NGSVKTCEVAAWCPVEDDTHVPQPAFL 179 C SDA C AG NG+ TGRCV + G KTCEV WCPVED V Q FL Sbjct: 131 VHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ--FL 188 Query: 180 KA-AENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVEN 238 A NFT+L+KN+I YPKF+FSK NI T YLK C + +D +CPIF+LG IVE Sbjct: 189 GTMAPNFTILIKNSIHYPKFHFSKGNIADR-TDGYLKRCTFHEASDLYCPIFKLGFIVEK 247 Query: 239 AGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAK 298 AG SF ++A +GG++G+ +NWDC+LD AS C P+YSFRRLD + V S GYNFRFAK Sbjct: 248 AGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVP--ASSGYNFRFAK 305 Query: 299 YYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVL 358 YY+ + G RTLIKAYGIR D+IV G+AGKF +IPT+IN+ + L +G+ + LCD I+L Sbjct: 306 YYK-INGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILL 364 Query: 359 YCMKKRLYYREKKYKYV 375 M K Y KK+ V Sbjct: 365 TFMNKNKVYSHKKFDKV 381 >gi|28416925 purinergic receptor P2X3 [Homo sapiens] Length = 397 Score = 344 bits (883), Expect = 7e-95 Identities = 171/366 (46%), Positives = 246/366 (67%), Gaps = 11/366 (3%) Query: 13 FEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVV-SSVTTKVKGV 71 F Y+T + V+++S +G++NR VQLLI++Y +GWVF+ EK YQ D+ + SSV TKVKG Sbjct: 8 FTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGS 67 Query: 72 AVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDAS 131 + R+ DV+DYV P Q + ++T +I+T NQ QG CPE + C SD+ Sbjct: 68 GLYAN-----RVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYR-CVSDSQ 121 Query: 132 CTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKN 191 C G G+ TGRCV ++ ++TCE+ WCP E DT V P ++A ENFT+ +KN Sbjct: 122 C--GPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDT-VETPIMMEA-ENFTIFIKN 177 Query: 192 NIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGG 251 +I +P FNF K N+LPN+T +K+C + DPFCPI R+G +V+ AG F +A GG Sbjct: 178 SIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGG 237 Query: 252 IMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTL 311 ++GI++ W C+LD+A C+P+YSF RLD+ + +VSPGYNFRFAKYY+ G+E RTL Sbjct: 238 VLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTL 297 Query: 312 IKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKK 371 +KA+GIRFD++V+G AGKF+IIPT+I+ + +G+ TVLCDII+L +K Y+ KK Sbjct: 298 LKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKK 357 Query: 372 YKYVED 377 ++ V + Sbjct: 358 FEEVNE 363 >gi|157419148 purinergic receptor P2X6 isoform 1 [Homo sapiens] Length = 441 Score = 341 bits (875), Expect = 6e-94 Identities = 168/364 (46%), Positives = 233/364 (64%), Gaps = 12/364 (3%) Query: 12 LFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVS-SVTTKVKG 70 L +Y T + V+ R+ +VG + R +Q I+ YV+GW + +KGYQE D S+ TK+KG Sbjct: 22 LLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKG 81 Query: 71 VAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTV-CKSD 129 V+VT +LG R+WDVAD+V P Q EN F++TN ++T Q QG CPE P C D Sbjct: 82 VSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWVD 141 Query: 130 ASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLV 189 C G GTHS+GV TG+CV FNG+ +TCE+ +WCPVE VP L A+NFTL + Sbjct: 142 EDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGV-VPSRPLLAQAQNFTLFI 200 Query: 190 KNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVE 249 KN + + KFNFSK N L TY K C Y+ + P+CP+FR+G +V AG +F+D+A+ Sbjct: 201 KNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIGDLVAKAGGTFEDLALL 260 Query: 250 GGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQR 309 GG +GI+V+WDC+LD S C P YSF+ + YNFR A ++ + G E R Sbjct: 261 GGSVGIRVHWDCDLDTGDSGCWPHYSFQLQE---------KSYNFRTATHWWEQPGVEAR 311 Query: 310 TLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYRE 369 TL+K YGIRFDI+V G+AGKF +IPT + +G+G A LG+ T CD+++LY ++ +Y Sbjct: 312 TLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDREAHFYWR 371 Query: 370 KKYK 373 KY+ Sbjct: 372 TKYE 375 >gi|29294631 purinergic receptor P2X7 [Homo sapiens] Length = 595 Score = 333 bits (854), Expect = 2e-91 Identities = 178/402 (44%), Positives = 239/402 (59%), Gaps = 35/402 (8%) Query: 1 MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV 60 M CC+ + +F+Y+T ++ I+S G + ++I +YV + V +K YQ + V Sbjct: 1 MPACCSC--SDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVC-FALVSDKLYQRKEPV 57 Query: 61 VSSVTTKVKGVAVTN-------TSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQ 113 +SSV TKVKG+A KL ++D ADY P Q NS FVMTN + T Q Q Sbjct: 58 ISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQG-NSFFVMTNFLKTEGQEQ 116 Query: 114 GLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHV 173 LCPE P T+C SD C G S G+ TGRCV + G+ KTCEV+AWCP+E Sbjct: 117 RLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEA 176 Query: 174 PQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLG 233 P+PA L +AENFT+L+KNNI +P N++ RNILP + T C + +P CPIFRLG Sbjct: 177 PRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNIT----CTFHKTQNPQCPIFRLG 232 Query: 234 KIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYN 293 I G +F D+A++GGIMGI++ WDCNLDR C P+YSFRRLD + ++ PGYN Sbjct: 233 DIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYN 292 Query: 294 FRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLC 353 FR+AKYY++ E+RTLIK +GIRFDI+VFG GKFDII ++ IGS L+ G+A V Sbjct: 293 FRYAKYYKE-NNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFI 351 Query: 354 DIIV-----------LY--------CMKKRLYYREKKYKYVE 376 D ++ +Y C+ YYR+K VE Sbjct: 352 DFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVE 393 >gi|28416935 purinergic receptor P2X5 isoform B [Homo sapiens] Length = 397 Score = 333 bits (854), Expect = 2e-91 Identities = 181/386 (46%), Positives = 240/386 (62%), Gaps = 51/386 (13%) Query: 5 CAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETD-SVVSS 63 C L LF+Y T + V+ +++KVGL+ R +Q ILAY++ WVF+ +KGYQ+ D S+ S+ Sbjct: 6 CKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSA 65 Query: 64 VTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDAT 123 V TKVKGVA TNTS LG RIWDVADYVIPAQ E IPD Sbjct: 66 VITKVKGVAFTNTSDLGQRIWDVADYVIPAQNEG---------------------IPDGA 104 Query: 124 TVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVK-TCEVAAWCPVEDDTHVPQPAFLKAA 182 C D+ C AG A T NGV TGRC+ + TCE+ AWCP+E + P+ FLK A Sbjct: 105 --CSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSR-PEEPFLKEA 161 Query: 183 ENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHS 242 E+FT+ +KN+I +PKFNFS N++ ++LKSC + K +CPIFRLG ++ AG Sbjct: 162 EDFTIFIKNHIRFPKFNFSN-NVMDVKDRSFLKSCHFGPKNH-YCPIFRLGSVIRWAGSD 219 Query: 243 FQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRD 302 FQD+A+EGG++GI + W+C+LD+AAS C P YSF RLD + + +VS GYNFRFA+YYRD Sbjct: 220 FQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNK-LSKSVSSGYNFRFARYYRD 278 Query: 303 LAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMK 362 AG E RTL+KAYGIRFD++V GK F CD++++Y +K Sbjct: 279 AAGVEFRTLMKAYGIRFDVMVNGKGAFF----------------------CDLVLIYLIK 316 Query: 363 KRLYYREKKYKYVEDYEQGLASELDQ 388 KR +YR+KKY+ V E D+ Sbjct: 317 KREFYRDKKYEEVRGLEDSSQEAEDE 342 >gi|25092733 purinergic receptor P2X2 isoform D [Homo sapiens] Length = 497 Score = 330 bits (847), Expect = 1e-90 Identities = 185/403 (45%), Positives = 250/403 (62%), Gaps = 45/403 (11%) Query: 3 GCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDS-VV 61 GC +AL ++Y+TP+++++R+R++G++ RAVQLLIL Y + +VF+ +K YQE+++ Sbjct: 20 GCWSAL----WDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPE 75 Query: 62 SSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPE-IP 120 SS+ TKVKG+ + ++WDV +YV P + + ++T V T +QTQG CPE I Sbjct: 76 SSIITKVKGITTSE-----HKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIR 130 Query: 121 DATTVCKSDASCTAGSAGTHSNGVSTGRCVAF-NGSVKTCEVAAWCPVEDDTHVPQPAFL 179 C SDA C AG NG+ TGRCV + G KTCEV WCPVED V Q FL Sbjct: 131 VHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ--FL 188 Query: 180 KA-AENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVEN 238 A NFT+L+KN+I YPKF+FSK NI T YLK C + +D +CPIF+LG IVE Sbjct: 189 GTMAPNFTILIKNSIHYPKFHFSKGNIADR-TDGYLKRCTFHEASDLYCPIFKLGFIVEK 247 Query: 239 AGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAK 298 AG SF ++A +GG++G+ +NWDC+LD AS C P+YSFRRLD + V S GYNFRFAK Sbjct: 248 AGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVP--ASSGYNFRFAK 305 Query: 299 YYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGM---------- 348 YY+ + G RTLIKAYGIR D+IV G+AGKF +IPT+IN+ + L +G+ Sbjct: 306 YYK-INGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVVRNPLWGPSG 364 Query: 349 ----------------ATVLCDIIVLYCMKKRLYYREKKYKYV 375 + LCD I+L M K Y KK+ V Sbjct: 365 CGGSTRPLHTGLCWPQGSFLCDWILLTFMNKNKVYSHKKFDKV 407 >gi|7706629 purinergic receptor P2X2 isoform C [Homo sapiens] Length = 447 Score = 319 bits (817), Expect = 3e-87 Identities = 177/376 (47%), Positives = 238/376 (63%), Gaps = 41/376 (10%) Query: 3 GCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDS-VV 61 GC +AL ++Y+TP+++++R+R++G++ RAVQLLIL Y + +VF+ +K YQE+++ Sbjct: 20 GCWSAL----WDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPE 75 Query: 62 SSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPD 121 SS+ TKVKG+ + ++WDV +YV P + I N T Sbjct: 76 SSIITKVKGITTSE-----HKVWDVEEYVKPPES----------IRVHNAT--------- 111 Query: 122 ATTVCKSDASCTAGSAGTHSNGVSTGRCVAF-NGSVKTCEVAAWCPVEDDTHVPQPAFLK 180 C SDA C AG NG+ TGRCV + G KTCEV WCPVED V Q FL Sbjct: 112 ----CLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ--FLG 165 Query: 181 A-AENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENA 239 A NFT+L+KN+I YPKF+FSK NI T YLK C + +D +CPIF+LG IVE A Sbjct: 166 TMAPNFTILIKNSIHYPKFHFSKGNIADR-TDGYLKRCTFHEASDLYCPIFKLGFIVEKA 224 Query: 240 GHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKY 299 G SF ++A +GG++G+ +NWDC+LD AS C P+YSFRRLD + V S GYNFRFAKY Sbjct: 225 GESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVP--ASSGYNFRFAKY 282 Query: 300 YRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLY 359 Y+ + G RTLIKAYGIR D+IV G+AGKF +IPT+IN+ + L +G+ + LCD I+L Sbjct: 283 YK-INGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLT 341 Query: 360 CMKKRLYYREKKYKYV 375 M K Y KK+ V Sbjct: 342 FMNKNKVYSHKKFDKV 357 >gi|227116341 purinergic receptor P2X6 isoform 2 [Homo sapiens] Length = 415 Score = 315 bits (806), Expect = 6e-86 Identities = 155/330 (46%), Positives = 211/330 (63%), Gaps = 12/330 (3%) Query: 46 WVFVWEKGYQETDSVVS-SVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTN 104 W + +KGYQE D S+ TK+KGV+VT +LG R+WDVAD+V P Q EN F++TN Sbjct: 30 WALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTN 89 Query: 105 VILTMNQTQGLCPEIPDATTV-CKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAA 163 ++T Q QG CPE P C D C G GTHS+GV TG+CV FNG+ +TCE+ + Sbjct: 90 FLVTPAQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWS 149 Query: 164 WCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKT 223 WCPVE VP L A+NFTL +KN + + KFNFSK N L TY K C Y+ + Sbjct: 150 WCPVESGV-VPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQF 208 Query: 224 DPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRD 283 P+CP+FR+G +V AG +F+D+A+ GG +GI+V+WDC+LD S C P YSF+ + Sbjct: 209 SPYCPVFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQE--- 265 Query: 284 VEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGL 343 YNFR A ++ + G E RTL+K YGIRFDI+V G+AGKF +IPT + +G+G Sbjct: 266 ------KSYNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGA 319 Query: 344 ALLGMATVLCDIIVLYCMKKRLYYREKKYK 373 A LG+ T CD+++LY ++ +Y KY+ Sbjct: 320 AWLGVVTFFCDLLLLYVDREAHFYWRTKYE 349 >gi|28416921 purinergic receptor P2X2 isoform H [Homo sapiens] Length = 379 Score = 258 bits (659), Expect = 6e-69 Identities = 136/252 (53%), Positives = 169/252 (67%), Gaps = 8/252 (3%) Query: 126 CKSDASCTAGSAGTHSNGVSTGRCVAF-NGSVKTCEVAAWCPVEDDTHVPQPAFLKA-AE 183 C SDA C AG NG+ TGRCV + G KTCEV WCPVED V Q FL A Sbjct: 44 CLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ--FLGTMAP 101 Query: 184 NFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSF 243 NFT+L+KN+I YPKF+FSK NI T YLK C + +D +CPIF+LG IVE AG SF Sbjct: 102 NFTILIKNSIHYPKFHFSKGNIADR-TDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESF 160 Query: 244 QDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDL 303 ++A +GG++G+ +NWDC+LD AS C P+YSFRRLD + V S GYNFRFAKYY+ + Sbjct: 161 TELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVP--ASSGYNFRFAKYYK-I 217 Query: 304 AGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKK 363 G RTLIKAYGIR D+IV G+AGKF +IPT+IN+ + L +G+ + LCD I+L M K Sbjct: 218 NGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNK 277 Query: 364 RLYYREKKYKYV 375 Y KK+ V Sbjct: 278 NKVYSHKKFDKV 289 >gi|27881423 purinergic receptor P2X2 isoform I [Homo sapiens] Length = 399 Score = 243 bits (619), Expect = 3e-64 Identities = 128/235 (54%), Positives = 161/235 (68%), Gaps = 8/235 (3%) Query: 143 GVSTGRCVAF-NGSVKTCEVAAWCPVEDDTHVPQPAFLKA-AENFTLLVKNNIWYPKFNF 200 G+ TGRCV + G KTCEV WCPVED V Q FL A NFT+L+KN+I YPKF+F Sbjct: 81 GLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQ--FLGTMAPNFTILIKNSIHYPKFHF 138 Query: 201 SKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWD 260 SK NI T YLK C + +D +CPIF+LG IVE AG SF ++A +GG++G+ +NWD Sbjct: 139 SKGNIADR-TDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWD 197 Query: 261 CNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFD 320 C+LD AS C P+YSFRRLD + V S GYNFRFAKYY+ + G RTLIKAYGIR D Sbjct: 198 CDLDLPASECNPKYSFRRLDPKHVP--ASSGYNFRFAKYYK-INGTTTRTLIKAYGIRID 254 Query: 321 IIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYV 375 +IV G+AGKF +IPT+IN+ + L +G+ + LCD I+L M K Y KK+ V Sbjct: 255 VIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKV 309 >gi|28416937 purinergic receptor P2X5 isoform C [Homo sapiens] Length = 178 Score = 175 bits (444), Expect = 5e-44 Identities = 92/169 (54%), Positives = 116/169 (68%), Gaps = 7/169 (4%) Query: 5 CAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETD-SVVSS 63 C L LF+Y T + V+ +++KVGL+ R +Q ILAY++ WVF+ +KGYQ+ D S+ S+ Sbjct: 6 CKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSA 65 Query: 64 VTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPE---IP 120 V TKVKGVA TNTS LG RIWDVADYVIPAQ EN FV+TN+I+T NQ Q +C E IP Sbjct: 66 VITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIP 125 Query: 121 DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVK-TCEVAAWCPVE 168 D C D+ C AG A T NGV TGRC+ + TCE+ AWCP+E Sbjct: 126 DG--ACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLE 172 >gi|53692193 Scm-like with four mbt domains 1 [Homo sapiens] Length = 866 Score = 30.8 bits (68), Expect = 2.2 Identities = 15/58 (25%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 240 GHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFA 297 G D G+ ++++W+ L+ S +P SF+ +DTR +++ +PG A Sbjct: 3 GEQQLDADAGSGMEEVELSWEDYLEETGSTAVPYGSFKHVDTR-LQNGFAPGMKLEVA 59 >gi|53692191 Scm-like with four mbt domains 1 [Homo sapiens] Length = 866 Score = 30.8 bits (68), Expect = 2.2 Identities = 15/58 (25%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 240 GHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFA 297 G D G+ ++++W+ L+ S +P SF+ +DTR +++ +PG A Sbjct: 3 GEQQLDADAGSGMEEVELSWEDYLEETGSTAVPYGSFKHVDTR-LQNGFAPGMKLEVA 59 >gi|53692195 Scm-like with four mbt domains 1 [Homo sapiens] Length = 866 Score = 30.8 bits (68), Expect = 2.2 Identities = 15/58 (25%), Positives = 29/58 (50%), Gaps = 1/58 (1%) Query: 240 GHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFA 297 G D G+ ++++W+ L+ S +P SF+ +DTR +++ +PG A Sbjct: 3 GEQQLDADAGSGMEEVELSWEDYLEETGSTAVPYGSFKHVDTR-LQNGFAPGMKLEVA 59 >gi|108860679 solute carrier family 25, member 27 [Homo sapiens] Length = 323 Score = 29.6 bits (65), Expect = 4.8 Identities = 12/27 (44%), Positives = 16/27 (59%) Query: 241 HSFQDMAVEGGIMGIQVNWDCNLDRAA 267 H+F + EGGI G+ W N+ RAA Sbjct: 175 HAFAKILAEGGIRGLWAGWVPNIQRAA 201 >gi|37577159 calcium-sensing receptor [Homo sapiens] Length = 1078 Score = 29.3 bits (64), Expect = 6.3 Identities = 23/95 (24%), Positives = 38/95 (40%), Gaps = 9/95 (9%) Query: 52 KGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQ 111 +G++ +++ ++ A+ LG+RI+D + V A E FV N I ++N Sbjct: 66 RGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNL 125 Query: 112 TQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVST 146 D C T G +GVST Sbjct: 126 ---------DEFCNCSEHIPSTIAVVGATGSGVST 151 >gi|11863152 jumonji, AT rich interactive domain 2 protein [Homo sapiens] Length = 1246 Score = 29.3 bits (64), Expect = 6.3 Identities = 19/71 (26%), Positives = 31/71 (43%), Gaps = 10/71 (14%) Query: 89 YVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGR 148 Y IPA+EEN L + + +L N T GL ++ ++ + + C G+ R Sbjct: 950 YCIPAEEENKLEDVVHTLLQANGTPGL--QMLESNVMISPEVLC--------KEGIKVHR 999 Query: 149 CVAFNGSVKTC 159 V +G C Sbjct: 1000 TVQQSGQFVVC 1010 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.323 0.138 0.427 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 13,802,319 Number of Sequences: 37866 Number of extensions: 576445 Number of successful extensions: 1301 Number of sequences better than 10.0: 21 Number of HSP's better than 10.0 without gapping: 16 Number of HSP's successfully gapped in prelim test: 5 Number of HSP's that attempted gapping in prelim test: 1206 Number of HSP's gapped (non-prelim): 22 length of query: 388 length of database: 18,247,518 effective HSP length: 104 effective length of query: 284 effective length of database: 14,309,454 effective search space: 4063884936 effective search space used: 4063884936 T: 11 A: 40 X1: 16 ( 7.5 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (22.0 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.