Search of human proteins with 28178821

Search of human proteins with 28178821

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|28178821 isocitrate dehydrogenase 3, beta subunit isoform a
precursor [Homo sapiens]
         (385 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|28178821 isocitrate dehydrogenase 3, beta subunit isoform a p...   761   0.0  
gi|28178816 isocitrate dehydrogenase 3, beta subunit isoform b p...   732   0.0  
gi|28178819 isocitrate dehydrogenase 3, beta subunit isoform c [...   416   e-116
gi|4758582 isocitrate dehydrogenase 3 (NAD+) gamma isoform a pre...   356   2e-98
gi|28178838 isocitrate dehydrogenase 3 (NAD+) gamma isoform b pr...   338   4e-93
gi|5031777 isocitrate dehydrogenase 3 (NAD+) alpha precursor [Ho...   278   5e-75
gi|84000432 hypothetical protein LOC157769 [Homo sapiens]              30   4.8  
gi|154354990 ankyrin repeat domain 26 [Homo sapiens]                   30   4.8  
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    29   6.3  

>gi|28178821 isocitrate dehydrogenase 3, beta subunit isoform a
           precursor [Homo sapiens]
          Length = 385

 Score =  761 bits (1964), Expect = 0.0
 Identities = 385/385 (100%), Positives = 385/385 (100%)

Query: 1   MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVG 60
           MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVG
Sbjct: 1   MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVG 60

Query: 61  PELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPME 120
           PELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPME
Sbjct: 61  PELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPME 120

Query: 121 YKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESAR 180
           YKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESAR
Sbjct: 121 YKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESAR 180

Query: 181 GVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY 240
           GVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY
Sbjct: 181 GVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY 240

Query: 241 PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY 300
           PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY
Sbjct: 241 PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY 300

Query: 301 AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRT 360
           AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRT
Sbjct: 301 AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRT 360

Query: 361 RDMGGYSTTTDFIKSVIGHLQTKGS 385
           RDMGGYSTTTDFIKSVIGHLQTKGS
Sbjct: 361 RDMGGYSTTTDFIKSVIGHLQTKGS 385


>gi|28178816 isocitrate dehydrogenase 3, beta subunit isoform b
           precursor [Homo sapiens]
          Length = 383

 Score =  732 bits (1889), Expect = 0.0
 Identities = 371/380 (97%), Positives = 374/380 (98%)

Query: 1   MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVG 60
           MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVG
Sbjct: 1   MAALSGVRWLTRALVSAGNPGAWRGLSTSAAAHAASRSQAEDVRVEGSFPVTMLPGDGVG 60

Query: 61  PELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPME 120
           PELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPME
Sbjct: 61  PELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPME 120

Query: 121 YKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESAR 180
           YKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESAR
Sbjct: 121 YKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSSLEHESAR 180

Query: 181 GVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY 240
           GVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY
Sbjct: 181 GVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELY 240

Query: 241 PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY 300
           PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY
Sbjct: 241 PKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEY 300

Query: 301 AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRT 360
           AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRT
Sbjct: 301 AVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRT 360

Query: 361 RDMGGYSTTTDFIKSVIGHL 380
            DMGGY+T  DF ++VI  L
Sbjct: 361 SDMGGYATCHDFTEAVIAAL 380


>gi|28178819 isocitrate dehydrogenase 3, beta subunit isoform c
           [Homo sapiens]
          Length = 233

 Score =  416 bits (1069), Expect = e-116
 Identities = 208/209 (99%), Positives = 209/209 (100%)

Query: 177 ESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV 236
           +SARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV
Sbjct: 25  QSARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEV 84

Query: 237 AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY 296
           AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY
Sbjct: 85  AELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESY 144

Query: 297 SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG 356
           SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG
Sbjct: 145 SAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVG 204

Query: 357 KVRTRDMGGYSTTTDFIKSVIGHLQTKGS 385
           KVRTRDMGGYSTTTDFIKSVIGHLQTKGS
Sbjct: 205 KVRTRDMGGYSTTTDFIKSVIGHLQTKGS 233


>gi|4758582 isocitrate dehydrogenase 3 (NAD+) gamma isoform a
           precursor [Homo sapiens]
          Length = 393

 Score =  356 bits (913), Expect = 2e-98
 Identities = 183/335 (54%), Positives = 235/335 (70%), Gaps = 3/335 (0%)

Query: 47  GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
           G   VTM+PGDG+GPELM  VK VF+ A VPV+F+E H+S   + A EE +   + +++ 
Sbjct: 53  GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVS---SNADEEDIRNAIMAIRR 109

Query: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
           N+VA+ G I T         S +  LR  LDL+ANV+H KSLPG +TRH ++D++I+RE 
Sbjct: 110 NRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVREN 169

Query: 167 TEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGD 226
           TEGEYSSLEHES  GV+E LKI+T+AKS RIA++AF  A + GR KVTAVHKANIMKLGD
Sbjct: 170 TEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGD 229

Query: 227 GLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 286
           GLFLQCC EVA  YP+I FE MI+DN  MQLV  P QFDV+VMPNLYGNI++N+ AGLVG
Sbjct: 230 GLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVG 289

Query: 287 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIA 346
           G G+V G +Y   YAVFET  R+       +NIANPTA LL++  ML HL L  +++ I 
Sbjct: 290 GPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIR 349

Query: 347 DAVKKVIKVGKVRTRDMGGYSTTTDFIKSVIGHLQ 381
            AV   +    + T D+GG  TT++ I+ VI H++
Sbjct: 350 KAVLASMDNENMHTPDIGGQGTTSEAIQDVIRHIR 384


>gi|28178838 isocitrate dehydrogenase 3 (NAD+) gamma isoform b
           precursor [Homo sapiens]
          Length = 380

 Score =  338 bits (868), Expect = 4e-93
 Identities = 173/303 (57%), Positives = 217/303 (71%), Gaps = 3/303 (0%)

Query: 47  GSFPVTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKE 106
           G   VTM+PGDG+GPELM  VK VF+ A VPV+F+E H+S   + A EE +   + +++ 
Sbjct: 53  GRHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVS---SNADEEDIRNAIMAIRR 109

Query: 107 NKVAIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQ 166
           N+VA+ G I T         S +  LR  LDL+ANV+H KSLPG +TRH ++D++I+RE 
Sbjct: 110 NRVALKGNIETNHNLPPSHKSRNNILRTSLDLYANVIHCKSLPGVVTRHKDIDILIVREN 169

Query: 167 TEGEYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGD 226
           TEGEYSSLEHES  GV+E LKI+T+AKS RIA++AF  A + GR KVTAVHKANIMKLGD
Sbjct: 170 TEGEYSSLEHESVAGVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGD 229

Query: 227 GLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVG 286
           GLFLQCC EVA  YP+I FE MI+DN  MQLV  P QFDV+VMPNLYGNI++N+ AGLVG
Sbjct: 230 GLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVG 289

Query: 287 GAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIA 346
           G G+V G +Y   YAVFET  R+       +NIANPTA LL++  ML HL L  +++ I 
Sbjct: 290 GPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDHLKLHSYATSIR 349

Query: 347 DAV 349
            AV
Sbjct: 350 KAV 352


>gi|5031777 isocitrate dehydrogenase 3 (NAD+) alpha precursor [Homo
           sapiens]
          Length = 366

 Score =  278 bits (712), Expect = 5e-75
 Identities = 146/328 (44%), Positives = 213/328 (64%), Gaps = 5/328 (1%)

Query: 51  VTMLPGDGVGPELMHAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKL-EQVLSSMKENKV 109
           VT++PGDG+GPE+  AV ++F AA  P++++E +++ +Q    +  +  +   SM +NK+
Sbjct: 34  VTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWMIPSEAKESMDKNKM 93

Query: 110 AIIGKIHTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169
            + G + TP+       S ++ LR+  DL+ANV    S+ GY T + ++++V IRE TEG
Sbjct: 94  GLKGPLKTPIA--AGHPSMNLLLRKTFDLYANVRPCVSIEGYKTPYTDVNIVTIRENTEG 151

Query: 170 EYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVTAVHKANIMKLGDGLF 229
           EYS +EH    GV++ +K++T   S+RIA+FAF+YA    R  VTAVHKANIM++ DGLF
Sbjct: 152 EYSGIEHVIVDGVVQSIKLITEGASKRIAEFAFEYARNNHRSNVTAVHKANIMRMSDGLF 211

Query: 230 LQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFDVLVMPNLYGNIIDNLAAGLVGGAG 289
           LQ C EVAE    IKF  M +D  C+ +VQ+P QFDVLVMPNLYG+I+ +L AGL+GG G
Sbjct: 212 LQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLG 271

Query: 290 VVPGESYSAE-YAVFETGARHPFAQAVGRNIANPTAMLLSASNMLRHLNLEYHSSMIADA 348
           V P  +  A   A+FE+          G+++ANPTA+LLSA  MLRH+ L  H++ I  A
Sbjct: 272 VTPSGNIGANGVAIFES-VHGTAPDIAGKDMANPTALLLSAVMMLRHMGLFDHAARIEAA 330

Query: 349 VKKVIKVGKVRTRDMGGYSTTTDFIKSV 376
               IK GK  T+D+GG +  +DF + +
Sbjct: 331 CFATIKDGKSLTKDLGGNAKCSDFTEEI 358


>gi|84000432 hypothetical protein LOC157769 [Homo sapiens]
          Length = 838

 Score = 29.6 bits (65), Expect = 4.8
 Identities = 26/105 (24%), Positives = 44/105 (41%), Gaps = 7/105 (6%)

Query: 115 IHTPM-----EYKGELASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEG 169
           +H P      E +GE    +M + + L +  N V ++ L GY+T  N    +  R+ ++ 
Sbjct: 614 VHVPFPFDETELQGEFTRVNMGVHKALQILRNRVDLQHLCGYVTMLNASSQLADRKLSDA 673

Query: 170 EYSSLEHESARGVIECLKIVTRAKSQRIAKFAFDYATKKGRGKVT 214
                E + A G    +   T +    I +   D ATK+  G  T
Sbjct: 674 SDERGEPDLASG--SDVNGSTESFEMVIEEATIDSATKQTSGATT 716


>gi|154354990 ankyrin repeat domain 26 [Homo sapiens]
          Length = 1710

 Score = 29.6 bits (65), Expect = 4.8
 Identities = 30/123 (24%), Positives = 52/123 (42%), Gaps = 5/123 (4%)

Query: 65   HAVKEVFKAAAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGE 124
            H  ++  +   + +E  +  LS+ Q    E + +     +K NK   IGK  +  E   +
Sbjct: 1081 HHTRDALREKTLGLERVQKDLSQTQCQMKEMEQKYQNEQVKVNKY--IGKQESVEERLSQ 1138

Query: 125  LASYDMRLRRKLDLFANVVHVKSLPGYMTRHNNLDLVIIREQTEGEYSS--LEHESARGV 182
            L S +M LR++LD   N    K     +   +    ++ + Q E E  S  LE  +   +
Sbjct: 1139 LQSENMLLRQQLDDAHNKADNKE-KTVINIQDQFHAIVQKLQAESEKQSLLLEERNKELI 1197

Query: 183  IEC 185
             EC
Sbjct: 1198 SEC 1200


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score = 29.3 bits (64), Expect = 6.3
 Identities = 24/84 (28%), Positives = 39/84 (46%), Gaps = 4/84 (4%)

Query: 74  AAVPVEFQEHHLSEVQNMASEEKLEQVLSSMKENKVAIIGKIHTPMEYKGELASYD-MRL 132
           A +  E+++  L E     +EEKL  +L+ +  N  A  G+  TP+      A Y+ +R+
Sbjct: 328 AVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHL---AAGYNRVRI 384

Query: 133 RRKLDLFANVVHVKSLPGYMTRHN 156
            + L      VH K   G +  HN
Sbjct: 385 VQLLLQHGADVHAKDKGGLVPLHN 408


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.132    0.379 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,007,251
Number of Sequences: 37866
Number of extensions: 520596
Number of successful extensions: 1440
Number of sequences better than 10.0: 9
Number of HSP's better than 10.0 without gapping: 6
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1431
Number of HSP's gapped (non-prelim): 9
length of query: 385
length of database: 18,247,518
effective HSP length: 104
effective length of query: 281
effective length of database: 14,309,454
effective search space: 4020956574
effective search space used: 4020956574
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.