BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo sapiens] (1170 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ... 2365 0.0 gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ... 2349 0.0 gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] 1475 0.0 gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] 1368 0.0 gi|62000702 diacylglycerol kinase kappa [Homo sapiens] 766 0.0 gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] 210 7e-54 gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] 210 7e-54 gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] 207 4e-53 gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 206 1e-52 gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 206 1e-52 gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 206 1e-52 gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] 206 1e-52 gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] 189 1e-47 gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] 164 6e-40 gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] 154 6e-37 gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] 151 4e-36 gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] 151 4e-36 gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] 150 7e-36 gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] 150 7e-36 gi|4758156 diacylglycerol kinase, iota [Homo sapiens] 142 2e-33 gi|40806175 diacylglycerol kinase, theta [Homo sapiens] 132 2e-30 gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1... 68 4e-11 gi|28557781 protein kinase C, eta [Homo sapiens] 66 2e-10 gi|47157325 protein kinase C, delta [Homo sapiens] 64 6e-10 gi|31377782 protein kinase C, delta [Homo sapiens] 64 6e-10 gi|4885563 protein kinase C, epsilon [Homo sapiens] 63 2e-09 gi|120659787 protein kinase D2 isoform B [Homo sapiens] 59 2e-08 gi|120659785 protein kinase D2 isoform A [Homo sapiens] 59 2e-08 gi|120659782 protein kinase D2 isoform A [Homo sapiens] 59 2e-08 gi|19923468 protein kinase D2 isoform A [Homo sapiens] 59 2e-08 >gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo sapiens] Length = 1170 Score = 2365 bits (6130), Expect = 0.0 Identities = 1170/1170 (100%), Positives = 1170/1170 (100%) Query: 1 MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVA 60 MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVA Sbjct: 1 MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVA 60 Query: 61 ESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMH 120 ESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMH Sbjct: 61 ESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMH 120 Query: 121 NWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKD 180 NWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKD Sbjct: 121 NWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKD 180 Query: 181 IIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLT 240 IIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLT Sbjct: 181 IIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLT 240 Query: 241 KCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQ 300 KCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQ Sbjct: 241 KCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQ 300 Query: 301 LLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVL 360 LLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVL Sbjct: 301 LLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVL 360 Query: 361 PLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTV 420 PLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTV Sbjct: 361 PLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTV 420 Query: 421 TEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEK 480 TEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEK Sbjct: 421 TEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEK 480 Query: 481 TTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSIC 540 TTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSIC Sbjct: 481 TTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSIC 540 Query: 541 GSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGF 600 GSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGF Sbjct: 541 GSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGF 600 Query: 601 VLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPP 660 VLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPP Sbjct: 601 VLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPP 660 Query: 661 QPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVM 720 QPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVM Sbjct: 661 QPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVM 720 Query: 721 NNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLE 780 NNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLE Sbjct: 721 NNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLE 780 Query: 781 CDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMA 840 CDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMA Sbjct: 781 CDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMA 840 Query: 841 VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRA 900 VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRA Sbjct: 841 VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRA 900 Query: 901 FESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRD 960 FESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRD Sbjct: 901 FESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRD 960 Query: 961 MEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQL 1020 MEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQL Sbjct: 961 MEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQL 1020 Query: 1021 DPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFK 1080 DPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFK Sbjct: 1021 DPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFK 1080 Query: 1081 KEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDL 1140 KEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDL Sbjct: 1081 KEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDL 1140 Query: 1141 KDLGVTKVGHMKRILCGIKELSRSAPAVEA 1170 KDLGVTKVGHMKRILCGIKELSRSAPAVEA Sbjct: 1141 KDLGVTKVGHMKRILCGIKELSRSAPAVEA 1170 >gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo sapiens] Length = 1214 Score = 2349 bits (6087), Expect = 0.0 Identities = 1162/1163 (99%), Positives = 1163/1163 (100%) Query: 8 QTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV 67 +TIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV Sbjct: 52 KTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV 111 Query: 68 NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH 127 NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH Sbjct: 112 NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH 171 Query: 128 ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG 187 ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG Sbjct: 172 ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG 231 Query: 188 IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC 247 IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC Sbjct: 232 IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC 291 Query: 248 KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 307 KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV Sbjct: 292 KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 351 Query: 308 FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND 367 FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND Sbjct: 352 FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND 411 Query: 368 LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED 427 LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED Sbjct: 412 LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED 471 Query: 428 SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE 487 SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE Sbjct: 472 SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE 531 Query: 488 SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL 547 SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL Sbjct: 532 SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL 591 Query: 548 VASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSES 607 VASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSES Sbjct: 592 VASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSES 651 Query: 608 EEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDG 667 EEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDG Sbjct: 652 EEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDG 711 Query: 668 LPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIG 727 LPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIG Sbjct: 712 LPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIG 771 Query: 728 LDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIP 787 LDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIP Sbjct: 772 LDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIP 831 Query: 788 LPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRL 847 LPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRL Sbjct: 832 LPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRL 891 Query: 848 QHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKS 907 QHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKS Sbjct: 892 QHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKS 951 Query: 908 WEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAH 967 WEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAH Sbjct: 952 WEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAH 1011 Query: 968 AVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQ 1027 AVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQ Sbjct: 1012 AVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQ 1071 Query: 1028 LGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKN 1087 LGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKN Sbjct: 1072 LGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKN 1131 Query: 1088 KEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTK 1147 KEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTK Sbjct: 1132 KEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTK 1191 Query: 1148 VGHMKRILCGIKELSRSAPAVEA 1170 VGHMKRILCGIKELSRSAPAVEA Sbjct: 1192 VGHMKRILCGIKELSRSAPAVEA 1214 >gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens] Length = 1220 Score = 1475 bits (3818), Expect = 0.0 Identities = 764/1175 (65%), Positives = 901/1175 (76%), Gaps = 32/1175 (2%) Query: 8 QTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV 67 +T IKEG L KQ +SFQR K+RYFKLRGRTLYYAK +KS+IFDEVDL+DASVAE+STKN Sbjct: 64 KTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNA 123 Query: 68 NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH 127 NNSFT+ITP R+L+LCA+NRKEMEDWI++LK+VQ RE +E Q++++HFSGMHNWYACSH Sbjct: 124 NNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSH 183 Query: 128 ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG 187 ARPT+CNVCRE+LSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED DG Sbjct: 184 ARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDG 243 Query: 188 IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC 247 +AMPHQWLEGNLPVSAKC VCDKTCGSVLRLQDW+CLWCK MVHT+CK+ CPLG C Sbjct: 244 VAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQC 303 Query: 248 KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 307 KVS+IPP ALNS DSDGF +A+ C SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV Sbjct: 304 KVSIIPPIALNSTDSDGFCRATF-SFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 362 Query: 308 FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND 367 FDLMNGGPHLGLRLFQKFD FRILVCGGDGSVGWVLSEID LNL+KQCQLGVLPLGTGND Sbjct: 363 FDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGND 422 Query: 368 LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED 427 LARVLGWG + DDDTQLPQILEKLERASTKMLDRWS+M YE KLP +AS + E Sbjct: 423 LARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKAS---LLPGPPEA 479 Query: 428 SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE 487 SE + YEDSVA HL+KIL SD+H+VVISSAK LCETVKDFVA+V K Y+KT E++ Sbjct: 480 SEEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVV 539 Query: 488 SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL 547 ++ +A KCSVL EKL+ LL+ L +SQA+ LP P I EE S G + ++L Sbjct: 540 ADAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQL 599 Query: 548 VASAC-PARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSE 606 P+ + +PRE +MLRANSLKKA+RQ+IE K +D+ E ++ Sbjct: 600 GDDVTKPSSQKAVKPRE-IMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEP------ANQ 652 Query: 607 SEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRD 666 S + ++ G + + + +SP + S G S S P S++ Sbjct: 653 SSDYDSTETDESKEEAKDDGAKESITVKTAPRSP-DARASYGH-SQTDSVPGPAVAASKE 710 Query: 667 GLPALNTKILYPNVRAGMSGSLPGGSVISRLLI-NADPFNSEP------ETLEYYTEKCV 719 LP LNT+I+ P +RAG++ S+ G S+I+++L+ N DPF + P ++++ Y+EKCV Sbjct: 711 NLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCV 770 Query: 720 MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLL 779 MNNYFGIGLDAKISL+FNNKR+EHPEKCRSRTKN+MWYGVLGT+ELL R+YKNLEQ+V L Sbjct: 771 MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQL 830 Query: 780 ECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQM 839 ECDG+ IPLPSLQGIAVLNIPSYAGGTNFWGGTKEDD FAAPSFDDKILEVVA+F SMQM Sbjct: 831 ECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQM 890 Query: 840 AVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDR 899 AVSRVI+LQHHRIAQCRTVKI+I GDEGVPVQVDGEAWVQPPG I+IVHKNRAQ LTRDR Sbjct: 891 AVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDR 950 Query: 900 AFESTLKSWEDKQKCELPRPPSCS----LHPEMLSEEEATQMDQFGQAAGVLIHSIREIA 955 AFESTLKSWEDKQKC+ +P + H L+ EE +QM QAA LI I + A Sbjct: 951 AFESTLKSWEDKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAA 1010 Query: 956 QSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGK 1015 H +EQELAHAVNA S ++++ PR E L E+ N +AL +ETE LL G+ Sbjct: 1011 TIHCLLEQELAHAVNACSHALNK--ANPRCPESLTRDTATEIAINVKALYNETESLLVGR 1068 Query: 1016 MALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKR-SRSGKFR 1074 + LQL+ P +E++ +AL ++ +L++L + PWL P ++E +D KR +RS FR Sbjct: 1069 VPLQLESPHEERVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFR 1128 Query: 1075 LVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLH 1134 +V KFKKEK K K + PV WGTEEVAAWL+ L+L EYKDIF RHDIRG+ELLH Sbjct: 1129 IVPKFKKEKVQKQKTS----SQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLH 1184 Query: 1135 LERRDLKDLGVTKVGHMKRILCGIKELSRSAPAVE 1169 LERRDLKDLG+ KVGH+KRIL GIKEL RS P E Sbjct: 1185 LERRDLKDLGIPKVGHVKRILQGIKELGRSTPQSE 1219 >gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens] Length = 1164 Score = 1368 bits (3540), Expect = 0.0 Identities = 707/1094 (64%), Positives = 838/1094 (76%), Gaps = 28/1094 (2%) Query: 8 QTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV 67 +T IKEG L KQ +SFQR K+RYFKLRGRTLYYAK +KS+IFDEVDL+DASVAE+STKN Sbjct: 64 KTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNA 123 Query: 68 NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH 127 NNSFT+ITP R+L+LCA+NRKEMEDWI++LK+VQ RE +E Q++++HFSGMHNWYACSH Sbjct: 124 NNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSH 183 Query: 128 ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG 187 ARPT+CNVCRE+LSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED DG Sbjct: 184 ARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDG 243 Query: 188 IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC 247 +AMPHQWLEGNLPVSAKC VCDKTCGSVLRLQDW+CLWCK MVHT+CK+ CPLG C Sbjct: 244 VAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQC 303 Query: 248 KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 307 KVS+IPP ALNS DSDGF +A+ C SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV Sbjct: 304 KVSIIPPIALNSTDSDGFCRATFS-FCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 362 Query: 308 FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND 367 FDLMNGGPHLGLRLFQKFD FRILVCGGDGSVGWVLSEID LNL+KQCQLGVLPLGTGND Sbjct: 363 FDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGND 422 Query: 368 LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED 427 LARVLGWG + DDDTQLPQILEKLERASTKMLDRWS+M YE KLP +AS + E Sbjct: 423 LARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKAS---LLPGPPEA 479 Query: 428 SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE 487 SE + YEDSVA HL+KIL SD+H+VVISSAK LCETVKDFVA+V K Y+KT E++ Sbjct: 480 SEEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVV 539 Query: 488 SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL 547 ++ +A KCSVL EKL+ LL+ L +SQA+ LP P I EE S G + ++L Sbjct: 540 ADAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQL 599 Query: 548 VASAC-PARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSE 606 P+ + +PRE +MLRANSLKKA+RQ+IE K +D+ E ++ Sbjct: 600 GDDVTKPSSQKAVKPRE-IMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPA------NQ 652 Query: 607 SEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRD 666 S + ++ G + + + +SP + S G S S P S++ Sbjct: 653 SSDYDSTETDESKEEAKDDGAKESITVKTAPRSP-DARASYGH-SQTDSVPGPAVAASKE 710 Query: 667 GLPALNTKILYPNVRAGMSGSLPGGSVISRLLI-NADPFNSEP------ETLEYYTEKCV 719 LP LNT+I+ P +RAG++ S+ G S+I+++L+ N DPF + P ++++ Y+EKCV Sbjct: 711 NLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCV 770 Query: 720 MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLL 779 MNNYFGIGLDAKISL+FNNKR+EHPEKCRSRTKN+MWYGVLGT+ELL R+YKNLEQ+V L Sbjct: 771 MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQL 830 Query: 780 ECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQM 839 ECDG+ IPLPSLQGIAVLNIPSYAGGTNFWGGTKEDD FAAPSFDDKILEVVA+F SMQM Sbjct: 831 ECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQM 890 Query: 840 AVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDR 899 AVSRVI+LQHHRIAQCRTVKI+I GDEGVPVQVDGEAWVQPPG I+IVHKNRAQ LTRDR Sbjct: 891 AVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDR 950 Query: 900 AFESTLKSWEDKQKCELPRPPSCSL----HPEMLSEEEATQMDQFGQAAGVLIHSIREIA 955 AFESTLKSWEDKQKC+ +P + H L+ EE +QM QAA LI I + A Sbjct: 951 AFESTLKSWEDKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAA 1010 Query: 956 QSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGK 1015 H +EQELAHAVNA S ++++ PR E L E+ N +AL +ETE LL G+ Sbjct: 1011 TIHCLLEQELAHAVNACSHALNKA--NPRCPESLTRDTATEIAINVKALYNETESLLVGR 1068 Query: 1016 MALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKR-SRSGKFR 1074 + LQL+ P +E++ +AL ++ +L++L + PWL P ++E +D KR +RS FR Sbjct: 1069 VPLQLESPHEERVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFR 1128 Query: 1075 LVTKFKKEKNNKNK 1088 +V KFKKEK K K Sbjct: 1129 IVPKFKKEKVQKQK 1142 >gi|62000702 diacylglycerol kinase kappa [Homo sapiens] Length = 1271 Score = 766 bits (1978), Expect = 0.0 Identities = 456/1117 (40%), Positives = 640/1117 (57%), Gaps = 109/1117 (9%) Query: 10 IIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNN 69 I+KEG + K NSF+R K RYF ++G+ LY+A F+ +DL+ A+VAESS +N+ + Sbjct: 217 ILKEGPMLKNCNSFKRWKLRYFLVQGQKLYFAHHPAFAHFETIDLSQATVAESSCRNLCH 276 Query: 70 SFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFE-PTQYSMDHFSGMHNWYACSHA 128 SF VITP RK+ L A NRK+ME+WI +KT+Q E ++ P + GMH WY+ Sbjct: 277 SFCVITPQRKITLAAPNRKDMEEWINIIKTIQQGEIYKIPAAENNPFLVGMHCWYSSYSH 336 Query: 129 RPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGI 188 R +CNVCRE++ ++ + CEVCK K+H+ CA+RA+ +CKW TL SI D++ AD + Sbjct: 337 RTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWNTL-SITDDLLLPADEV 395 Query: 189 AMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCK 248 MPHQW+EGN+PVS++C VC ++CGS RLQD+RCLWC + VH C+ +C + Sbjct: 396 NMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRFSKECCFRSHR 455 Query: 249 VSVIPPTALNSIDSDG-------FWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQL 301 SVIPPTAL+ DG FW +C+ PLL+F+NSKSGD+QG+ FLR+FKQ Sbjct: 456 SSVIPPTALSDPKGDGQLVVSSDFWNLDWSSACSCPLLIFINSKSGDHQGIVFLRKFKQY 515 Query: 302 LNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLP 361 LNP+QVFDL+ GGP GL +F+ F FRILVCGGDGSV WVLS ID+ LH++CQL V+P Sbjct: 516 LNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGSVSWVLSLIDAFGLHEKCQLAVIP 575 Query: 362 LGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVT 421 LGTGNDLARVLGWG+ + IL ++E+AS ++LDRWSVM E PRQ Sbjct: 576 LGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASVRILDRWSVMIRET--PRQTPLLKGQ 633 Query: 422 EDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKT 481 + + + +S A L+KIL + + +I + + LC V+DFV + KA+ + Sbjct: 634 VEMDVPRFEAAAIQHLESAATELNKILKAKYPTEMIIATRFLCSAVEDFVVDIVKAWGQI 693 Query: 482 TESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICG 541 +++ + K ++ ++L L+ L +E+ A+S+ + A E D Sbjct: 694 KQNNTAIVSVILKSDLMYDRLSVLIDVLAEEAAATSAEKS-----ATEYAD--------S 740 Query: 542 STGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGF- 600 S DR P I + + +L +A SL+K+++ II E+A+DE++ QT + F Sbjct: 741 SKADR--KPFIPQIDHIAKCKLELATKAQSLQKSLKLIIFQVEQALDEESRQTISVKNFS 798 Query: 601 -VLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLP 659 L + E ++ P+ RS+R G+LS SS Sbjct: 799 STFFLEDDPEDINQT------------SPRRRSRR-------------GTLSSISSL--- 830 Query: 660 PQPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCV 719 + L LN D + PE++ + EKCV Sbjct: 831 ----KSEDLDNLN----------------------------LDHLHFTPESIR-FKEKCV 857 Query: 720 MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLL 779 MNNYFGIGLDAKISLDFN +RDEHP + SR KN MWYG+LGTKELL R+Y+ LE++V L Sbjct: 858 MNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVHL 917 Query: 780 ECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQM 839 ECDG I LP+LQGI VLNI SYAGG NFWG + AP+ DD LEVVA+FGS+QM Sbjct: 918 ECDGETISLPNLQGIVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAIFGSVQM 977 Query: 840 AVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDR 899 A+SR+I L HHRIAQC V I+I G+EG+PVQVDGEAW+Q PG I+I +KN AQ LTRDR Sbjct: 978 AMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKNAAQMLTRDR 1037 Query: 900 AFESTLKSWEDKQKCELPRPPSCSL----HPEMLSEEEATQMDQFGQAAGVLIHSIREIA 955 FE+++K WE K E+ P L E LS+EE QM + A LI + +++ Sbjct: 1038 DFENSMKMWEYKH-TEIQAAPQPQLDFQDSQESLSDEEYAQMQHLARLAENLISKLNDLS 1096 Query: 956 QSHRDMEQELAHAVNASSKSM-DRVYGKPR----------TTEGLNCSFVLEMVNNFRAL 1004 + H+ + L +VNAS+ + D YG+ E L+ + +++ + + L Sbjct: 1097 KIHQHV-SVLMGSVNASANILNDIFYGQDSGNEMGAASCIPIETLSRNDAVDVTFSLKGL 1155 Query: 1005 RSETELLLSGKMALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDL 1064 +T L K+ + + L SAL M+++ ++L++ W+ P +E+S D Sbjct: 1156 YDDTTAFLDEKLLRSAE--DETALQSALDAMNKEFKKLSEIDWMNPIFVP-EEKSSDTDS 1212 Query: 1065 AKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLW 1101 KF + K K E+ K K S +LW Sbjct: 1213 RSLRLKIKFPKLGKKKVEEERKPKSGQSVQSFIGNLW 1249 >gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens] Length = 773 Score = 210 bits (534), Expect = 7e-54 Identities = 120/330 (36%), Positives = 154/330 (46%), Gaps = 55/330 (16%) Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177 G H W +P YCN+C L GV GL C CK+ H+RC RA +C T + S Sbjct: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302 Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237 + M H W+EGN P KC C KT L C+WC+ +H C Sbjct: 303 RNTDV-------MHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353 Query: 238 LLTKCPLGLCKVSVIPPTAL---------------------------------------- 257 L +C G K ++PPT + Sbjct: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413 Query: 258 -----NSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 312 NS+ DG P T PLLVFVN KSG QG + R+F+ LLNP QV+ L Sbjct: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473 Query: 313 GGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVL 372 GP GL F+ FR+L CGGDG+VGWVL I+ N+ K + +LPLGTGNDLAR L Sbjct: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533 Query: 373 GWGSACDDDTQLPQILEKLERASTKMLDRW 402 WG + + L +IL+ +E ++ MLDRW Sbjct: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562 Score = 127 bits (320), Expect = 5e-29 Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 ++NNYF IG+DA I+ F+ R++HPEK SR KN WY GT E T K L + V Sbjct: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641 Query: 779 LECDGRPIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 814 +ECDG I L SL+GIA+LNIPS GG+N WG +K + Sbjct: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701 Query: 815 DDTFAAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVD 873 + FA+ D++LEVV + G+M+M + ++ R+AQC V I + +P+Q+D Sbjct: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759 Query: 874 GEAWVQPP 881 GE W+Q P Sbjct: 760 GEPWMQTP 767 >gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens] Length = 804 Score = 210 bits (534), Expect = 7e-54 Identities = 120/330 (36%), Positives = 154/330 (46%), Gaps = 55/330 (16%) Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177 G H W +P YCN+C L GV GL C CK+ H+RC RA +C T + S Sbjct: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302 Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237 + M H W+EGN P KC C KT L C+WC+ +H C Sbjct: 303 RNTDV-------MHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353 Query: 238 LLTKCPLGLCKVSVIPPTAL---------------------------------------- 257 L +C G K ++PPT + Sbjct: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413 Query: 258 -----NSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 312 NS+ DG P T PLLVFVN KSG QG + R+F+ LLNP QV+ L Sbjct: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473 Query: 313 GGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVL 372 GP GL F+ FR+L CGGDG+VGWVL I+ N+ K + +LPLGTGNDLAR L Sbjct: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533 Query: 373 GWGSACDDDTQLPQILEKLERASTKMLDRW 402 WG + + L +IL+ +E ++ MLDRW Sbjct: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562 Score = 139 bits (351), Expect = 1e-32 Identities = 81/202 (40%), Positives = 113/202 (55%), Gaps = 27/202 (13%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 ++NNYF IG+DA I+ F+ R++HPEK SR KN WY GT E T K L + V Sbjct: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641 Query: 779 LECDGRPIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 814 +ECDG I L SL+GIA+LNIPS GG+N WG +K + Sbjct: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701 Query: 815 DDTFAAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVD 873 + FA+ D++LEVV + G+M+M + ++ R+AQC V I + +P+Q+D Sbjct: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759 Query: 874 GEAWVQPPGYIRIVHKNRAQTL 895 GE W+Q P I+I HKN+A L Sbjct: 760 GEPWMQTPCTIKITHKNQAPML 781 >gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens] Length = 791 Score = 207 bits (528), Expect = 4e-53 Identities = 122/301 (40%), Positives = 152/301 (50%), Gaps = 28/301 (9%) Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177 G H W +PTYCN C L GV GL C CK+ H+RC R C T + Sbjct: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKA- 328 Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237 G M H W+EGN S KC C K+ + C+WC+ H C+ Sbjct: 329 ------KRSGEVMQHAWVEGNS--SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE-- 378 Query: 238 LLTKCPLGLCKVSVIPPTALNSID-------SDGFWKAS---------CPPSCTSPLLVF 281 L T C G + ++ PT++ I SDG A P T PLLV Sbjct: 379 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438 Query: 282 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGW 341 VN KSG QG + LR+F LLNP QVF+L NGGP GL F+ FR+L CGGDG+VGW Sbjct: 439 VNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGW 498 Query: 342 VLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 401 +L ID N K + VLPLGTGNDLAR L WG + + L +IL+ +E++ MLDR Sbjct: 499 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 557 Query: 402 W 402 W Sbjct: 558 W 558 Score = 140 bits (354), Expect = 5e-33 Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 21/193 (10%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 +MNNYF IG+DA I+ F+ R++HPEK SR KN +WY GT E T K L + Sbjct: 578 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 637 Query: 779 LECDGRPIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDT----------------FAA 820 LECDG + L + L+GIA+LNIPS GGTN WG K++ F Sbjct: 638 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 697 Query: 821 PSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQ 879 D++LEVV + G+M+M + ++ R+AQC +V +I ++ +P+QVDGE W+Q Sbjct: 698 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 755 Query: 880 PPGYIRIVHKNRA 892 P I+I HKN+A Sbjct: 756 PCCTIKITHKNQA 768 >gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens] Length = 735 Score = 206 bits (523), Expect = 1e-52 Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%) Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177 G H W RP YCN+C ++ G+ GLSC +CK+ H +CA++A C+ +T A Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261 Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237 KDI G+ H W+ G S +C C K L C+WC +H C ++ Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314 Query: 238 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 275 + +C GL + ++PP+++ S+ + G + + P T Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374 Query: 276 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 335 PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ RILVCGG Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434 Query: 336 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 395 DG+VGW+L ID NL + VLPLGTGNDLAR L WG + L +IL+ LE + Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493 Query: 396 TKMLDRWSV 404 +DRWSV Sbjct: 494 VVHMDRWSV 502 Score = 126 bits (317), Expect = 1e-28 Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 ++NNYF IG+DA I+ F+ R+++PEK SR KN +WY T E + T K LE+ + Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579 Query: 779 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 818 +E G+P+ L SL+GIAVLNIPS GG+N WG T+ D + Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639 Query: 819 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 872 P DK LEVV + G+++M + ++ R+A+C +I+ + +P+Q+ Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697 Query: 873 DGEAWVQPPGYIRIVHKNRAQTL 895 DGE W+Q P I+I HKN+ L Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720 >gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens] Length = 735 Score = 206 bits (523), Expect = 1e-52 Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%) Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177 G H W RP YCN+C ++ G+ GLSC +CK+ H +CA++A C+ +T A Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261 Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237 KDI G+ H W+ G S +C C K L C+WC +H C ++ Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314 Query: 238 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 275 + +C GL + ++PP+++ S+ + G + + P T Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374 Query: 276 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 335 PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ RILVCGG Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434 Query: 336 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 395 DG+VGW+L ID NL + VLPLGTGNDLAR L WG + L +IL+ LE + Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493 Query: 396 TKMLDRWSV 404 +DRWSV Sbjct: 494 VVHMDRWSV 502 Score = 126 bits (317), Expect = 1e-28 Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 ++NNYF IG+DA I+ F+ R+++PEK SR KN +WY T E + T K LE+ + Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579 Query: 779 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 818 +E G+P+ L SL+GIAVLNIPS GG+N WG T+ D + Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639 Query: 819 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 872 P DK LEVV + G+++M + ++ R+A+C +I+ + +P+Q+ Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697 Query: 873 DGEAWVQPPGYIRIVHKNRAQTL 895 DGE W+Q P I+I HKN+ L Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720 >gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens] Length = 735 Score = 206 bits (523), Expect = 1e-52 Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%) Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177 G H W RP YCN+C ++ G+ GLSC +CK+ H +CA++A C+ +T A Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261 Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237 KDI G+ H W+ G S +C C K L C+WC +H C ++ Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314 Query: 238 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 275 + +C GL + ++PP+++ S+ + G + + P T Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374 Query: 276 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 335 PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ RILVCGG Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434 Query: 336 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 395 DG+VGW+L ID NL + VLPLGTGNDLAR L WG + L +IL+ LE + Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493 Query: 396 TKMLDRWSV 404 +DRWSV Sbjct: 494 VVHMDRWSV 502 Score = 126 bits (317), Expect = 1e-28 Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 ++NNYF IG+DA I+ F+ R+++PEK SR KN +WY T E + T K LE+ + Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579 Query: 779 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 818 +E G+P+ L SL+GIAVLNIPS GG+N WG T+ D + Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639 Query: 819 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 872 P DK LEVV + G+++M + ++ R+A+C +I+ + +P+Q+ Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697 Query: 873 DGEAWVQPPGYIRIVHKNRAQTL 895 DGE W+Q P I+I HKN+ L Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720 >gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens] Length = 735 Score = 206 bits (523), Expect = 1e-52 Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%) Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177 G H W RP YCN+C ++ G+ GLSC +CK+ H +CA++A C+ +T A Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261 Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237 KDI G+ H W+ G S +C C K L C+WC +H C ++ Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314 Query: 238 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 275 + +C GL + ++PP+++ S+ + G + + P T Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374 Query: 276 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 335 PLLVFVN KSG QG + L +F+ +LNP QVF+L+ GP +GLRLF+ RILVCGG Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434 Query: 336 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 395 DG+VGW+L ID NL + VLPLGTGNDLAR L WG + L +IL+ LE + Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493 Query: 396 TKMLDRWSV 404 +DRWSV Sbjct: 494 VVHMDRWSV 502 Score = 126 bits (317), Expect = 1e-28 Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 ++NNYF IG+DA I+ F+ R+++PEK SR KN +WY T E + T K LE+ + Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579 Query: 779 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 818 +E G+P+ L SL+GIAVLNIPS GG+N WG T+ D + Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639 Query: 819 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 872 P DK LEVV + G+++M + ++ R+A+C +I+ + +P+Q+ Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697 Query: 873 DGEAWVQPPGYIRIVHKNRAQTL 895 DGE W+Q P I+I HKN+ L Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720 >gi|4503313 diacylglycerol kinase epsilon [Homo sapiens] Length = 567 Score = 189 bits (481), Expect = 1e-47 Identities = 132/396 (33%), Positives = 191/396 (48%), Gaps = 41/396 (10%) Query: 120 HNWYACS-HARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNN--CKWTTLAS 176 H W ++PTYC VC + + G C+ C + + C +A CK L + Sbjct: 60 HGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115 Query: 177 IGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKE 236 K + AMPH W+ GN+P+ + C VC + CG +L D+RC+WC+ VH C + Sbjct: 116 DTKVLD------AMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMK 169 Query: 237 SLL--TKCPLGLCKVSVIPPTALNSID-------SDGFWKASCPPSCTSPLLVFVNSKSG 287 + L KC G K +IPP+ L SI+ +D AS +PL++ NS+SG Sbjct: 170 NSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSG 229 Query: 288 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRL--FQKFDTFRILVCGGDGSVGWVLSE 345 N G L F+ LLNP QVFD+ P L+L + + R+LVCGGDG+VGWVL Sbjct: 230 TNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDA 289 Query: 346 IDSLNLHKQ----CQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 401 +D + + Q Q+ VLPLGTGNDL+ LGWG+ + + Q+L + A LDR Sbjct: 290 VDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDR 349 Query: 402 WSVMA-----YEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVV 456 W V Y + P++ T+ FS + L + AH K S S + Sbjct: 350 WKVQVTNKGYYNLRKPKE---FTMNNYFSVGPDALMALNFH----AHREK-APSLFSSRI 401 Query: 457 ISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMA 492 ++ A L KD + + K K E + E +A Sbjct: 402 LNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVA 437 Score = 133 bits (335), Expect = 9e-31 Identities = 84/221 (38%), Positives = 117/221 (52%), Gaps = 10/221 (4%) Query: 683 GMSGSLPGGSVISRLL----INADPFNSEPETLEYYT----EKCVMNNYFGIGLDAKISL 734 G +G +P V+ ++ I D + + YY ++ MNNYF +G DA ++L Sbjct: 325 GYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMAL 384 Query: 735 DFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGI 794 +F+ R++ P SR N Y GTK+ L + K+L +KV LE DG + LPSL+GI Sbjct: 385 NFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPSLEGI 444 Query: 795 AVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQ 854 VLNI + GG W G D+T+ DD +LEVV V+GS A +V RI Q Sbjct: 445 IVLNIGYWGGGCRLWEG-MGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQ 503 Query: 855 CRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTL 895 TV++ IL +P+QVDGE W Q P + I HK A L Sbjct: 504 AHTVRL-ILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543 >gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens] Length = 766 Score = 164 bits (414), Expect = 6e-40 Identities = 106/301 (35%), Positives = 134/301 (44%), Gaps = 53/301 (17%) Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177 G H W +PTYCN C L GV GL C CK+ H+RC R C T + Sbjct: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKA- 328 Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237 G M H W+EGN S KC C K+ + C+WC+ H C+ Sbjct: 329 ------KRSGEVMQHAWVEGNS--SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE-- 378 Query: 238 LLTKCPLGLCKVSVIPPTALNSID-------SDGFWKAS---------CPPSCTSPLLVF 281 L T C G + ++ PT++ I SDG A P T PLLV Sbjct: 379 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438 Query: 282 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGW 341 VN KSG QG + L F+ FR+L CGGDG+VGW Sbjct: 439 VNPKSGGRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGW 473 Query: 342 VLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 401 +L ID N K + VLPLGTGNDLAR L WG + + L +IL+ +E++ MLDR Sbjct: 474 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 532 Query: 402 W 402 W Sbjct: 533 W 533 Score = 140 bits (354), Expect = 5e-33 Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 21/193 (10%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 +MNNYF IG+DA I+ F+ R++HPEK SR KN +WY GT E T K L + Sbjct: 553 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 612 Query: 779 LECDGRPIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDT----------------FAA 820 LECDG + L + L+GIA+LNIPS GGTN WG K++ F Sbjct: 613 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 672 Query: 821 PSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQ 879 D++LEVV + G+M+M + ++ R+AQC +V +I ++ +P+QVDGE W+Q Sbjct: 673 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 730 Query: 880 PPGYIRIVHKNRA 892 P I+I HKN+A Sbjct: 731 PCCTIKITHKNQA 743 >gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens] Length = 752 Score = 154 bits (388), Expect = 6e-37 Identities = 108/301 (35%), Positives = 137/301 (45%), Gaps = 67/301 (22%) Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177 G H W +PTYCN C L GV GL C CK+T Sbjct: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTY----------------CKYT----- 308 Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237 + + + N+P C KT R ++ H C+ Sbjct: 309 ------------VHERCVSRNIPG------CVKTYSKAKRSGEF---------HRKCE-- 339 Query: 238 LLTKCPLGLCKVSVIPPTALNSID-------SDGFWKAS---------CPPSCTSPLLVF 281 L T C G + ++ PT++ I SDG A P T PLLV Sbjct: 340 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 399 Query: 282 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGW 341 VN KSG QG + LR+F LLNP QVF+L NGGP GL F+ FR+L CGGDG+VGW Sbjct: 400 VNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGW 459 Query: 342 VLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 401 +L ID N K + VLPLGTGNDLAR L WG + + L +IL+ +E++ MLDR Sbjct: 460 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 518 Query: 402 W 402 W Sbjct: 519 W 519 Score = 140 bits (354), Expect = 5e-33 Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 21/193 (10%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 +MNNYF IG+DA I+ F+ R++HPEK SR KN +WY GT E T K L + Sbjct: 539 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 598 Query: 779 LECDGRPIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDT----------------FAA 820 LECDG + L + L+GIA+LNIPS GGTN WG K++ F Sbjct: 599 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 658 Query: 821 PSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQ 879 D++LEVV + G+M+M + ++ R+AQC +V +I ++ +P+QVDGE W+Q Sbjct: 659 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 716 Query: 880 PPGYIRIVHKNRA 892 P I+I HKN+A Sbjct: 717 PCCTIKITHKNQA 729 >gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens] Length = 929 Score = 151 bits (381), Expect = 4e-36 Identities = 108/337 (32%), Positives = 145/337 (43%), Gaps = 56/337 (16%) Query: 118 GMHNWYACS------HARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATN---N 168 G H W+ + + YC V R V+ C CK H C + Sbjct: 96 GEHIWFETNVSGDFCYVGEQYC-VARMLQKSVSRR--KCAACKIVVHTPCIEQLEKINFR 152 Query: 169 CKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWR-----C 223 CK + S +++ E + H W+ KC C K C Sbjct: 153 CKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISC 208 Query: 224 LWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL-------NSIDS---------- 262 WCK H+ +L + C LG+ VIPPT + N++ + Sbjct: 209 SWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFK 268 Query: 263 ---------DGFWKA----SCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFD 309 +G W+ P PLLVFVN KSG NQG K ++ F LNP QVFD Sbjct: 269 RKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFD 328 Query: 310 LMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLA 369 L GGP L +++K RIL CGGDG+VGW+LS +D L L + +LPLGTGNDLA Sbjct: 329 LSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLA 388 Query: 370 RVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 406 R L WG D+ + +IL +E + LDRW + A Sbjct: 389 RTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 424 Score = 99.4 bits (246), Expect = 2e-20 Identities = 77/278 (27%), Positives = 126/278 (45%), Gaps = 23/278 (8%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L + K+L + + Sbjct: 447 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 506 Query: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833 + CDG + P +Q + LNIP Y GT WG E F DD LEV+ Sbjct: 507 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 565 Query: 834 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 893 +M + + R+ QCR V ++ + +PVQVDGE IRI +N+A Sbjct: 566 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 620 Query: 894 TLTRDRAFESTLKSWEDKQ------KCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVL 947 T+ + S D+Q + ++ R S+H + Q+ + G + Sbjct: 621 TMVQKAKRRSAAPLHSDQQPVPEQLRIQVSR---VSMHDYEALHYDKEQLKEASVPLGTV 677 Query: 948 I---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 982 + S E+ ++H + Q+ A S + ++ K Sbjct: 678 VVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 715 >gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens] Length = 895 Score = 151 bits (381), Expect = 4e-36 Identities = 108/337 (32%), Positives = 145/337 (43%), Gaps = 56/337 (16%) Query: 118 GMHNWYACS------HARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATN---N 168 G H W+ + + YC V R V+ C CK H C + Sbjct: 62 GEHIWFETNVSGDFCYVGEQYC-VARMLQKSVSRR--KCAACKIVVHTPCIEQLEKINFR 118 Query: 169 CKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWR-----C 223 CK + S +++ E + H W+ KC C K C Sbjct: 119 CKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISC 174 Query: 224 LWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL-------NSIDS---------- 262 WCK H+ +L + C LG+ VIPPT + N++ + Sbjct: 175 SWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFK 234 Query: 263 ---------DGFWKA----SCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFD 309 +G W+ P PLLVFVN KSG NQG K ++ F LNP QVFD Sbjct: 235 RKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFD 294 Query: 310 LMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLA 369 L GGP L +++K RIL CGGDG+VGW+LS +D L L + +LPLGTGNDLA Sbjct: 295 LSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLA 354 Query: 370 RVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 406 R L WG D+ + +IL +E + LDRW + A Sbjct: 355 RTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 390 Score = 99.4 bits (246), Expect = 2e-20 Identities = 77/278 (27%), Positives = 126/278 (45%), Gaps = 23/278 (8%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L + K+L + + Sbjct: 413 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 472 Query: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833 + CDG + P +Q + LNIP Y GT WG E F DD LEV+ Sbjct: 473 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 531 Query: 834 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 893 +M + + R+ QCR V ++ + +PVQVDGE IRI +N+A Sbjct: 532 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 586 Query: 894 TLTRDRAFESTLKSWEDKQ------KCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVL 947 T+ + S D+Q + ++ R S+H + Q+ + G + Sbjct: 587 TMVQKAKRRSAAPLHSDQQPVPEQLRIQVSR---VSMHDYEALHYDKEQLKEASVPLGTV 643 Query: 948 I---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 982 + S E+ ++H + Q+ A S + ++ K Sbjct: 644 VVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 681 >gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens] Length = 1117 Score = 150 bits (379), Expect = 7e-36 Identities = 100/299 (33%), Positives = 133/299 (44%), Gaps = 47/299 (15%) Query: 150 CEVCKFKAHKRCAVRATN---NCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCT 206 C CK H C + CK + S +++ E + H W+ KC Sbjct: 319 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCR 374 Query: 207 VCDKTCGSVLRLQDWR-----CLWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL 257 C K C WCK H+ +L + C LG+ VIPPT + Sbjct: 375 HCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI 434 Query: 258 -------NSIDS-------------------DGFWKA----SCPPSCTSPLLVFVNSKSG 287 N++ + +G W+ P PLLVFVN KSG Sbjct: 435 LRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSG 494 Query: 288 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEID 347 NQG K ++ F LNP QVFDL GGP L +++K RIL CGGDG+VGW+LS +D Sbjct: 495 GNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLD 554 Query: 348 SLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 406 L L + +LPLGTGNDLAR L WG D+ + +IL +E + LDRW + A Sbjct: 555 QLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 612 Score = 99.4 bits (246), Expect = 2e-20 Identities = 77/278 (27%), Positives = 126/278 (45%), Gaps = 23/278 (8%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L + K+L + + Sbjct: 635 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 694 Query: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833 + CDG + P +Q + LNIP Y GT WG E F DD LEV+ Sbjct: 695 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 753 Query: 834 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 893 +M + + R+ QCR V ++ + +PVQVDGE IRI +N+A Sbjct: 754 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 808 Query: 894 TLTRDRAFESTLKSWEDKQ------KCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVL 947 T+ + S D+Q + ++ R S+H + Q+ + G + Sbjct: 809 TMVQKAKRRSAAPLHSDQQPVPEQLRIQVSR---VSMHDYEALHYDKEQLKEASVPLGTV 865 Query: 948 I---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 982 + S E+ ++H + Q+ A S + ++ K Sbjct: 866 VVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 903 >gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens] Length = 945 Score = 150 bits (379), Expect = 7e-36 Identities = 100/299 (33%), Positives = 133/299 (44%), Gaps = 47/299 (15%) Query: 150 CEVCKFKAHKRCAVRATN---NCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCT 206 C CK H C + CK + S +++ E + H W+ KC Sbjct: 147 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCR 202 Query: 207 VCDKTCGSVLRLQDWR-----CLWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL 257 C K C WCK H+ +L + C LG+ VIPPT + Sbjct: 203 HCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI 262 Query: 258 -------NSIDS-------------------DGFWKA----SCPPSCTSPLLVFVNSKSG 287 N++ + +G W+ P PLLVFVN KSG Sbjct: 263 LRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSG 322 Query: 288 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEID 347 NQG K ++ F LNP QVFDL GGP L +++K RIL CGGDG+VGW+LS +D Sbjct: 323 GNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLD 382 Query: 348 SLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 406 L L + +LPLGTGNDLAR L WG D+ + +IL +E + LDRW + A Sbjct: 383 QLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 440 Score = 99.4 bits (246), Expect = 2e-20 Identities = 77/278 (27%), Positives = 126/278 (45%), Gaps = 23/278 (8%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L + K+L + + Sbjct: 463 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 522 Query: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833 + CDG + P +Q + LNIP Y GT WG E F DD LEV+ Sbjct: 523 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 581 Query: 834 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 893 +M + + R+ QCR V ++ + +PVQVDGE IRI +N+A Sbjct: 582 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 636 Query: 894 TLTRDRAFESTLKSWEDKQ------KCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVL 947 T+ + S D+Q + ++ R S+H + Q+ + G + Sbjct: 637 TMVQKAKRRSAAPLHSDQQPVPEQLRIQVSR---VSMHDYEALHYDKEQLKEASVPLGTV 693 Query: 948 I---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 982 + S E+ ++H + Q+ A S + ++ K Sbjct: 694 VVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 731 >gi|4758156 diacylglycerol kinase, iota [Homo sapiens] Length = 1065 Score = 142 bits (358), Expect = 2e-33 Identities = 101/299 (33%), Positives = 127/299 (42%), Gaps = 50/299 (16%) Query: 150 CEVCKFKAHKRCAVRATN---NCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCT 206 C VCK H C + CK T + E+ + H W+ KC Sbjct: 210 CAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENF----VRHHWVHRRRQ-EGKCK 264 Query: 207 VCDKTCGSVLRLQDWR-----CLWCKAMVHTSCKESLL----TKCPLGLCKVSVIPPTAL 257 C K C WCK H +L C LG ++PPT + Sbjct: 265 QCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWI 324 Query: 258 -------NSIDSDG-------------------------FWKASCPPSCTSPLLVFVNSK 285 NS+ + F PLLVFVN K Sbjct: 325 IKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPK 384 Query: 286 SGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSE 345 SG NQG K L+ F LNP QVFDL GP L L++K RIL CGGDG+VGW+LS Sbjct: 385 SGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSI 444 Query: 346 IDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSV 404 +D L L Q +GVLPLGTGNDLAR L WG D+ + +IL ++E + LDRW++ Sbjct: 445 LDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDE-PVSKILCQVEDGTVVQLDRWNL 502 Score = 103 bits (257), Expect = 1e-21 Identities = 63/188 (33%), Positives = 98/188 (52%), Gaps = 14/188 (7%) Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778 V NNYF +G DA ++L+F+ R+ +PEK SR +N M+Y + L R+ ++L + V Sbjct: 526 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVK 585 Query: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833 + CDG + P +Q I LNIP Y GT WG + F DD +EV+ Sbjct: 586 VVCDGTDL-TPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVI-- 642 Query: 834 FGSMQMAVSRVIRLQHH--RIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNR 891 MA +++ H R+ QCR ++ +L + +P+QVDGE P IRI +N+ Sbjct: 643 --GFTMASLAALQVGGHGERLHQCR--EVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQ 698 Query: 892 AQTLTRDR 899 A + + + Sbjct: 699 ANMVQKSK 706 >gi|40806175 diacylglycerol kinase, theta [Homo sapiens] Length = 942 Score = 132 bits (332), Expect = 2e-30 Identities = 78/180 (43%), Positives = 102/180 (56%), Gaps = 13/180 (7%) Query: 271 PPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRI 330 P SC PLLVFVN KSG +G L F++LLNP QVFDL NGGP GL LF + FR+ Sbjct: 584 PDSC--PLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRV 641 Query: 331 LVCGGDGSVGWVLSEIDSLNLHKQC---QLGVLPLGTGNDLARVLGWGSACDDDTQLPQI 387 LVCGGDG+VGWVL ++ C + +LPLGTGNDL RVL WG+ + + Sbjct: 642 LVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPF-SV 700 Query: 388 LEKLERASTKMLDRWSVM--AYEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLS 445 L ++ A ++DRW+++ A+EA S+ T D VQ + + A LS Sbjct: 701 LLSVDEADAVLMDRWTILLDAHEA-----GSAENDTADAEPPKIVQMSNYCGIGIDAELS 755 Score = 119 bits (297), Expect = 2e-26 Identities = 69/183 (37%), Positives = 109/183 (59%), Gaps = 6/183 (3%) Query: 705 NSEPETLEYYTEKCV-MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTK 763 ++E +T + K V M+NY GIG+DA++SLDF+ R+E P K SR N Y +G + Sbjct: 726 SAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQ 785 Query: 764 ELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSF 823 ++ H ++L +++ L+ + + + LPS++G+ +NIPS+ G + W G+ D F P Sbjct: 786 KISHS--RSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLW-GSDSDTRFEKPRM 842 Query: 824 DDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGY 883 DD +LEVV V G + M + RIAQ ++++L + PVQVDGE WVQ PG+ Sbjct: 843 DDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLL--KATPVQVDGEPWVQAPGH 900 Query: 884 IRI 886 + I Sbjct: 901 MII 903 Score = 87.4 bits (215), Expect = 7e-17 Identities = 49/136 (36%), Positives = 65/136 (47%), Gaps = 11/136 (8%) Query: 132 YCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMP 191 +C VCR+ L H CEVC+ H C A ++C+ +D +D D Sbjct: 134 FCAVCRKVLEAPALH---CEVCELHLHPDCVPFACSDCR-----QCHQDGHQDHD--THH 183 Query: 192 HQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSV 251 H W EGNLP A+C VC KTCGS L RC WC H+ C +L +C G + V Sbjct: 184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLRSLV 243 Query: 252 IPPTALNSIDSDGFWK 267 +PP + + GF K Sbjct: 244 LPPACVRLLPG-GFSK 258 Score = 44.7 bits (104), Expect = 5e-04 Identities = 28/123 (22%), Positives = 51/123 (41%), Gaps = 15/123 (12%) Query: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGK 179 H++ + +PT+C++C + + G+ G C+VC F +H++C C S+ Sbjct: 61 HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-----TSVAP 113 Query: 180 DIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLL 239 ++ + + H + L C VC K VL C C+ +H C Sbjct: 114 SLVR----VPVAHCFGPRGLHKRKFCAVCRK----VLEAPALHCEVCELHLHPDCVPFAC 165 Query: 240 TKC 242 + C Sbjct: 166 SDC 168 Score = 35.4 bits (80), Expect = 0.32 Identities = 19/65 (29%), Positives = 28/65 (43%), Gaps = 1/65 (1%) Query: 114 DHFSGMHNWYACSHARPTYCNVCREAL-SGVTSHGLSCEVCKFKAHKRCAVRATNNCKWT 172 DH + H+W + C VCR+ S G+ CE C +AH C+ C + Sbjct: 178 DHDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFG 237 Query: 173 TLASI 177 L S+ Sbjct: 238 RLRSL 242 >gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1 [Homo sapiens] Length = 1849 Score = 68.2 bits (165), Expect = 4e-11 Identities = 33/65 (50%), Positives = 45/65 (69%) Query: 1097 PVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILC 1156 PVHLW +VA WLE L+L E+K+ F ++I GS L +L++ DL DLGVT+VGH I Sbjct: 1782 PVHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIER 1841 Query: 1157 GIKEL 1161 +K+L Sbjct: 1842 ALKQL 1846 >gi|28557781 protein kinase C, eta [Homo sapiens] Length = 683 Score = 66.2 bits (160), Expect = 2e-10 Identities = 39/125 (31%), Positives = 55/125 (44%), Gaps = 3/125 (2%) Query: 120 HNWYACSHARPTYCNVCREALSGV-TSHGLSCEVCKFKAHKRCAVRATNNCK-WTTLASI 177 H + A +PTYC+ CRE + GV G C+VC HKRC C + + Sbjct: 172 HKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKV 231 Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237 I E GI +PH++ N V C C ++R Q +C CK VH C+ + Sbjct: 232 DSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMR-QGLQCKICKMNVHIRCQAN 290 Query: 238 LLTKC 242 + C Sbjct: 291 VAPNC 295 Score = 45.8 bits (107), Expect = 2e-04 Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 5/58 (8%) Query: 112 SMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169 ++ H +HN+ PT+C+ C L G+ GL C++CK H RC NC Sbjct: 243 NIPHKFSIHNYKV-----PTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNC 295 >gi|47157325 protein kinase C, delta [Homo sapiens] Length = 676 Score = 64.3 bits (155), Expect = 6e-10 Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 7/131 (5%) Query: 115 HFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTL 174 H+ H + A +PT+C+VC++ + G+ G C C HK+C + C T Sbjct: 154 HYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAA 213 Query: 175 ASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSV---LRLQDWRCLWCKAMVH 231 S ++ I MPH++ N T CD CGS+ L Q +C C VH Sbjct: 214 NSRDTIFQKERFNIDMPHRFKVHNY---MSPTFCDH-CGSLLWGLVKQGLKCEDCGMNVH 269 Query: 232 TSCKESLLTKC 242 C+E + C Sbjct: 270 HKCREKVANLC 280 >gi|31377782 protein kinase C, delta [Homo sapiens] Length = 676 Score = 64.3 bits (155), Expect = 6e-10 Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 7/131 (5%) Query: 115 HFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTL 174 H+ H + A +PT+C+VC++ + G+ G C C HK+C + C T Sbjct: 154 HYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAA 213 Query: 175 ASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSV---LRLQDWRCLWCKAMVH 231 S ++ I MPH++ N T CD CGS+ L Q +C C VH Sbjct: 214 NSRDTIFQKERFNIDMPHRFKVHNY---MSPTFCDH-CGSLLWGLVKQGLKCEDCGMNVH 269 Query: 232 TSCKESLLTKC 242 C+E + C Sbjct: 270 HKCREKVANLC 280 >gi|4885563 protein kinase C, epsilon [Homo sapiens] Length = 737 Score = 62.8 bits (151), Expect = 2e-09 Identities = 43/148 (29%), Positives = 60/148 (40%), Gaps = 9/148 (6%) Query: 120 HNWYACSHARPTYCNVCREALSGVT-SHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIG 178 H + A +PTYC+ CR+ + GV G C+VC HKRC C Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETP 229 Query: 179 KDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESL 238 + + MPH++ N V C C +LR Q +C CK VH C+ ++ Sbjct: 230 DQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLR-QGLQCKVCKMNVHRRCETNV 288 Query: 239 LTKCPL---GLCKV----SVIPPTALNS 259 C + G+ KV V P NS Sbjct: 289 APNCGVDARGIAKVLADLGVTPDKITNS 316 Score = 51.6 bits (122), Expect = 4e-06 Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 7/77 (9%) Query: 95 AALKTVQNREHFEPTQYS--MDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEV 152 A LK + + ++S M H G+HN+ PT+C+ C L G+ GL C+V Sbjct: 221 AGLKKQETPDQVGSQRFSVNMPHKFGIHNYKV-----PTFCDHCGSLLWGLLRQGLQCKV 275 Query: 153 CKFKAHKRCAVRATNNC 169 CK H+RC NC Sbjct: 276 CKMNVHRRCETNVAPNC 292 >gi|120659787 protein kinase D2 isoform B [Homo sapiens] Length = 721 Score = 59.3 bits (142), Expect = 2e-08 Identities = 23/50 (46%), Positives = 30/50 (60%) Query: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169 H + S+ RPT C C++ L G+ GL C+ CKF HKRCA R N+C Sbjct: 108 HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDC 157 Score = 35.0 bits (79), Expect = 0.42 Identities = 14/30 (46%), Positives = 16/30 (53%) Query: 140 LSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169 L G+ GL C+ C HKRCA NNC Sbjct: 2 LFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 31 >gi|120659785 protein kinase D2 isoform A [Homo sapiens] Length = 878 Score = 59.3 bits (142), Expect = 2e-08 Identities = 23/50 (46%), Positives = 30/50 (60%) Query: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169 H + S+ RPT C C++ L G+ GL C+ CKF HKRCA R N+C Sbjct: 265 HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDC 314 Score = 47.4 bits (111), Expect = 8e-05 Identities = 19/44 (43%), Positives = 24/44 (54%) Query: 126 SHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169 S+ P +C+ C E L G+ GL C+ C HKRCA NNC Sbjct: 145 SYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 188 >gi|120659782 protein kinase D2 isoform A [Homo sapiens] Length = 878 Score = 59.3 bits (142), Expect = 2e-08 Identities = 23/50 (46%), Positives = 30/50 (60%) Query: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169 H + S+ RPT C C++ L G+ GL C+ CKF HKRCA R N+C Sbjct: 265 HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDC 314 Score = 47.4 bits (111), Expect = 8e-05 Identities = 19/44 (43%), Positives = 24/44 (54%) Query: 126 SHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169 S+ P +C+ C E L G+ GL C+ C HKRCA NNC Sbjct: 145 SYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 188 >gi|19923468 protein kinase D2 isoform A [Homo sapiens] Length = 878 Score = 59.3 bits (142), Expect = 2e-08 Identities = 23/50 (46%), Positives = 30/50 (60%) Query: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169 H + S+ RPT C C++ L G+ GL C+ CKF HKRCA R N+C Sbjct: 265 HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDC 314 Score = 47.4 bits (111), Expect = 8e-05 Identities = 19/44 (43%), Positives = 24/44 (54%) Query: 126 SHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169 S+ P +C+ C E L G+ GL C+ C HKRCA NNC Sbjct: 145 SYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 188 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.132 0.395 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 47,097,586 Number of Sequences: 37866 Number of extensions: 2223687 Number of successful extensions: 8156 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 104 Number of HSP's successfully gapped in prelim test: 138 Number of HSP's that attempted gapping in prelim test: 7675 Number of HSP's gapped (non-prelim): 472 length of query: 1170 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1057 effective length of database: 13,968,660 effective search space: 14764873620 effective search space used: 14764873620 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.