Guide to the Human Genome
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Search of human proteins with 25777596

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
sapiens]
         (1170 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo ...  2365   0.0  
gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo ...  2349   0.0  
gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]      1475   0.0  
gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]      1368   0.0  
gi|62000702 diacylglycerol kinase kappa [Homo sapiens]                766   0.0  
gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]      210   7e-54
gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]      210   7e-54
gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]     207   4e-53
gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]         206   1e-52
gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]         206   1e-52
gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]         206   1e-52
gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]         206   1e-52
gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]               189   1e-47
gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]     164   6e-40
gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]     154   6e-37
gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]       151   4e-36
gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]       151   4e-36
gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]      150   7e-36
gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]       150   7e-36
gi|4758156 diacylglycerol kinase, iota [Homo sapiens]                 142   2e-33
gi|40806175 diacylglycerol kinase, theta [Homo sapiens]               132   2e-30
gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1...    68   4e-11
gi|28557781 protein kinase C, eta [Homo sapiens]                       66   2e-10
gi|47157325 protein kinase C, delta [Homo sapiens]                     64   6e-10
gi|31377782 protein kinase C, delta [Homo sapiens]                     64   6e-10
gi|4885563 protein kinase C, epsilon [Homo sapiens]                    63   2e-09
gi|120659787 protein kinase D2 isoform B [Homo sapiens]                59   2e-08
gi|120659785 protein kinase D2 isoform A [Homo sapiens]                59   2e-08
gi|120659782 protein kinase D2 isoform A [Homo sapiens]                59   2e-08
gi|19923468 protein kinase D2 isoform A [Homo sapiens]                 59   2e-08

>gi|25777596 diacylglycerol kinase, delta 130kDa isoform 1 [Homo
            sapiens]
          Length = 1170

 Score = 2365 bits (6130), Expect = 0.0
 Identities = 1170/1170 (100%), Positives = 1170/1170 (100%)

Query: 1    MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVA 60
            MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVA
Sbjct: 1    MNMFLYFQTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVA 60

Query: 61   ESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMH 120
            ESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMH
Sbjct: 61   ESSTKNVNNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMH 120

Query: 121  NWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKD 180
            NWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKD
Sbjct: 121  NWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKD 180

Query: 181  IIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLT 240
            IIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLT
Sbjct: 181  IIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLT 240

Query: 241  KCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQ 300
            KCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQ
Sbjct: 241  KCPLGLCKVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQ 300

Query: 301  LLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVL 360
            LLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVL
Sbjct: 301  LLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVL 360

Query: 361  PLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTV 420
            PLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTV
Sbjct: 361  PLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTV 420

Query: 421  TEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEK 480
            TEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEK
Sbjct: 421  TEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEK 480

Query: 481  TTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSIC 540
            TTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSIC
Sbjct: 481  TTESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSIC 540

Query: 541  GSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGF 600
            GSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGF
Sbjct: 541  GSTGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGF 600

Query: 601  VLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPP 660
            VLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPP
Sbjct: 601  VLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPP 660

Query: 661  QPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVM 720
            QPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVM
Sbjct: 661  QPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVM 720

Query: 721  NNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLE 780
            NNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLE
Sbjct: 721  NNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLE 780

Query: 781  CDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMA 840
            CDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMA
Sbjct: 781  CDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMA 840

Query: 841  VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRA 900
            VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRA
Sbjct: 841  VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRA 900

Query: 901  FESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRD 960
            FESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRD
Sbjct: 901  FESTLKSWEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRD 960

Query: 961  MEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQL 1020
            MEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQL
Sbjct: 961  MEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQL 1020

Query: 1021 DPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFK 1080
            DPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFK
Sbjct: 1021 DPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFK 1080

Query: 1081 KEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDL 1140
            KEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDL
Sbjct: 1081 KEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDL 1140

Query: 1141 KDLGVTKVGHMKRILCGIKELSRSAPAVEA 1170
            KDLGVTKVGHMKRILCGIKELSRSAPAVEA
Sbjct: 1141 KDLGVTKVGHMKRILCGIKELSRSAPAVEA 1170


>gi|25777598 diacylglycerol kinase, delta 130kDa isoform 2 [Homo
            sapiens]
          Length = 1214

 Score = 2349 bits (6087), Expect = 0.0
 Identities = 1162/1163 (99%), Positives = 1163/1163 (100%)

Query: 8    QTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV 67
            +TIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV
Sbjct: 52   KTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV 111

Query: 68   NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH 127
            NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH
Sbjct: 112  NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH 171

Query: 128  ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG 187
            ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG
Sbjct: 172  ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG 231

Query: 188  IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC 247
            IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC
Sbjct: 232  IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC 291

Query: 248  KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 307
            KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV
Sbjct: 292  KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 351

Query: 308  FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND 367
            FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND
Sbjct: 352  FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND 411

Query: 368  LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED 427
            LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED
Sbjct: 412  LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED 471

Query: 428  SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE 487
            SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE
Sbjct: 472  SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE 531

Query: 488  SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL 547
            SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL
Sbjct: 532  SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL 591

Query: 548  VASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSES 607
            VASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSES
Sbjct: 592  VASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSES 651

Query: 608  EEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDG 667
            EEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDG
Sbjct: 652  EEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRDG 711

Query: 668  LPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIG 727
            LPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIG
Sbjct: 712  LPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCVMNNYFGIG 771

Query: 728  LDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIP 787
            LDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIP
Sbjct: 772  LDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIP 831

Query: 788  LPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRL 847
            LPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRL
Sbjct: 832  LPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRL 891

Query: 848  QHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKS 907
            QHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKS
Sbjct: 892  QHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDRAFESTLKS 951

Query: 908  WEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAH 967
            WEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAH
Sbjct: 952  WEDKQKCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVLIHSIREIAQSHRDMEQELAH 1011

Query: 968  AVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQ 1027
            AVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQ
Sbjct: 1012 AVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGKMALQLDPPQKEQ 1071

Query: 1028 LGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKN 1087
            LGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKN
Sbjct: 1072 LGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKRSRSGKFRLVTKFKKEKNNKN 1131

Query: 1088 KEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTK 1147
            KEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTK
Sbjct: 1132 KEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTK 1191

Query: 1148 VGHMKRILCGIKELSRSAPAVEA 1170
            VGHMKRILCGIKELSRSAPAVEA
Sbjct: 1192 VGHMKRILCGIKELSRSAPAVEA 1214


>gi|29788751 diacylglycerol kinase, eta isoform 2 [Homo sapiens]
          Length = 1220

 Score = 1475 bits (3818), Expect = 0.0
 Identities = 764/1175 (65%), Positives = 901/1175 (76%), Gaps = 32/1175 (2%)

Query: 8    QTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV 67
            +T IKEG L KQ +SFQR K+RYFKLRGRTLYYAK +KS+IFDEVDL+DASVAE+STKN 
Sbjct: 64   KTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNA 123

Query: 68   NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH 127
            NNSFT+ITP R+L+LCA+NRKEMEDWI++LK+VQ RE +E  Q++++HFSGMHNWYACSH
Sbjct: 124  NNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSH 183

Query: 128  ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG 187
            ARPT+CNVCRE+LSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED DG
Sbjct: 184  ARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDG 243

Query: 188  IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC 247
            +AMPHQWLEGNLPVSAKC VCDKTCGSVLRLQDW+CLWCK MVHT+CK+     CPLG C
Sbjct: 244  VAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQC 303

Query: 248  KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 307
            KVS+IPP ALNS DSDGF +A+    C SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV
Sbjct: 304  KVSIIPPIALNSTDSDGFCRATF-SFCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 362

Query: 308  FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND 367
            FDLMNGGPHLGLRLFQKFD FRILVCGGDGSVGWVLSEID LNL+KQCQLGVLPLGTGND
Sbjct: 363  FDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGND 422

Query: 368  LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED 427
            LARVLGWG + DDDTQLPQILEKLERASTKMLDRWS+M YE KLP +AS   +     E 
Sbjct: 423  LARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKAS---LLPGPPEA 479

Query: 428  SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE 487
            SE   +  YEDSVA HL+KIL SD+H+VVISSAK LCETVKDFVA+V K Y+KT E++  
Sbjct: 480  SEEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVV 539

Query: 488  SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL 547
            ++ +A KCSVL EKL+ LL+ L  +SQA+  LP   P I EE      S    G + ++L
Sbjct: 540  ADAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQL 599

Query: 548  VASAC-PARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSE 606
                  P+  +  +PRE +MLRANSLKKA+RQ+IE   K +D+      E        ++
Sbjct: 600  GDDVTKPSSQKAVKPRE-IMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEP------ANQ 652

Query: 607  SEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRD 666
            S +            ++  G  +  + +   +SP +   S G  S   S   P    S++
Sbjct: 653  SSDYDSTETDESKEEAKDDGAKESITVKTAPRSP-DARASYGH-SQTDSVPGPAVAASKE 710

Query: 667  GLPALNTKILYPNVRAGMSGSLPGGSVISRLLI-NADPFNSEP------ETLEYYTEKCV 719
             LP LNT+I+ P +RAG++ S+ G S+I+++L+ N DPF + P      ++++ Y+EKCV
Sbjct: 711  NLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCV 770

Query: 720  MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLL 779
            MNNYFGIGLDAKISL+FNNKR+EHPEKCRSRTKN+MWYGVLGT+ELL R+YKNLEQ+V L
Sbjct: 771  MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQL 830

Query: 780  ECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQM 839
            ECDG+ IPLPSLQGIAVLNIPSYAGGTNFWGGTKEDD FAAPSFDDKILEVVA+F SMQM
Sbjct: 831  ECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQM 890

Query: 840  AVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDR 899
            AVSRVI+LQHHRIAQCRTVKI+I GDEGVPVQVDGEAWVQPPG I+IVHKNRAQ LTRDR
Sbjct: 891  AVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDR 950

Query: 900  AFESTLKSWEDKQKCELPRPPSCS----LHPEMLSEEEATQMDQFGQAAGVLIHSIREIA 955
            AFESTLKSWEDKQKC+  +P   +     H   L+ EE +QM    QAA  LI  I + A
Sbjct: 951  AFESTLKSWEDKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAA 1010

Query: 956  QSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGK 1015
              H  +EQELAHAVNA S ++++    PR  E L      E+  N +AL +ETE LL G+
Sbjct: 1011 TIHCLLEQELAHAVNACSHALNK--ANPRCPESLTRDTATEIAINVKALYNETESLLVGR 1068

Query: 1016 MALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKR-SRSGKFR 1074
            + LQL+ P +E++ +AL  ++ +L++L + PWL     P ++E   +D  KR +RS  FR
Sbjct: 1069 VPLQLESPHEERVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFR 1128

Query: 1075 LVTKFKKEKNNKNKEAHSSLGAPVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLH 1134
            +V KFKKEK  K K +      PV  WGTEEVAAWL+ L+L EYKDIF RHDIRG+ELLH
Sbjct: 1129 IVPKFKKEKVQKQKTS----SQPVQKWGTEEVAAWLDLLNLGEYKDIFIRHDIRGAELLH 1184

Query: 1135 LERRDLKDLGVTKVGHMKRILCGIKELSRSAPAVE 1169
            LERRDLKDLG+ KVGH+KRIL GIKEL RS P  E
Sbjct: 1185 LERRDLKDLGIPKVGHVKRILQGIKELGRSTPQSE 1219


>gi|29788760 diacylglycerol kinase, eta isoform 1 [Homo sapiens]
          Length = 1164

 Score = 1368 bits (3540), Expect = 0.0
 Identities = 707/1094 (64%), Positives = 838/1094 (76%), Gaps = 28/1094 (2%)

Query: 8    QTIIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNV 67
            +T IKEG L KQ +SFQR K+RYFKLRGRTLYYAK +KS+IFDEVDL+DASVAE+STKN 
Sbjct: 64   KTSIKEGQLLKQTSSFQRWKKRYFKLRGRTLYYAKDSKSLIFDEVDLSDASVAEASTKNA 123

Query: 68   NNSFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFEPTQYSMDHFSGMHNWYACSH 127
            NNSFT+ITP R+L+LCA+NRKEMEDWI++LK+VQ RE +E  Q++++HFSGMHNWYACSH
Sbjct: 124  NNSFTIITPFRRLMLCAENRKEMEDWISSLKSVQTREPYEVAQFNVEHFSGMHNWYACSH 183

Query: 128  ARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADG 187
            ARPT+CNVCRE+LSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIED DG
Sbjct: 184  ARPTFCNVCRESLSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDEDG 243

Query: 188  IAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLC 247
            +AMPHQWLEGNLPVSAKC VCDKTCGSVLRLQDW+CLWCK MVHT+CK+     CPLG C
Sbjct: 244  VAMPHQWLEGNLPVSAKCAVCDKTCGSVLRLQDWKCLWCKTMVHTACKDLYHPICPLGQC 303

Query: 248  KVSVIPPTALNSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 307
            KVS+IPP ALNS DSDGF +A+    C SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV
Sbjct: 304  KVSIIPPIALNSTDSDGFCRATFS-FCVSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQV 362

Query: 308  FDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGND 367
            FDLMNGGPHLGLRLFQKFD FRILVCGGDGSVGWVLSEID LNL+KQCQLGVLPLGTGND
Sbjct: 363  FDLMNGGPHLGLRLFQKFDNFRILVCGGDGSVGWVLSEIDKLNLNKQCQLGVLPLGTGND 422

Query: 368  LARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVTEDFSED 427
            LARVLGWG + DDDTQLPQILEKLERASTKMLDRWS+M YE KLP +AS   +     E 
Sbjct: 423  LARVLGWGGSYDDDTQLPQILEKLERASTKMLDRWSIMTYELKLPPKAS---LLPGPPEA 479

Query: 428  SEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKTTESSEE 487
            SE   +  YEDSVA HL+KIL SD+H+VVISSAK LCETVKDFVA+V K Y+KT E++  
Sbjct: 480  SEEFYMTIYEDSVATHLTKILNSDEHAVVISSAKTLCETVKDFVAKVEKTYDKTLENAVV 539

Query: 488  SEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICGSTGDRL 547
            ++ +A KCSVL EKL+ LL+ L  +SQA+  LP   P I EE      S    G + ++L
Sbjct: 540  ADAVASKCSVLNEKLEQLLQALHTDSQAAPVLPGLSPLIVEEDAVESSSEESLGESKEQL 599

Query: 548  VASAC-PARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGFVLGLSE 606
                  P+  +  +PRE +MLRANSLKKA+RQ+IE   K +D+      E        ++
Sbjct: 600  GDDVTKPSSQKAVKPRE-IMLRANSLKKAVRQVIEEAGKVMDDPTVHPCEPA------NQ 652

Query: 607  SEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLPPQPGSRD 666
            S +            ++  G  +  + +   +SP +   S G  S   S   P    S++
Sbjct: 653  SSDYDSTETDESKEEAKDDGAKESITVKTAPRSP-DARASYGH-SQTDSVPGPAVAASKE 710

Query: 667  GLPALNTKILYPNVRAGMSGSLPGGSVISRLLI-NADPFNSEP------ETLEYYTEKCV 719
             LP LNT+I+ P +RAG++ S+ G S+I+++L+ N DPF + P      ++++ Y+EKCV
Sbjct: 711  NLPVLNTRIICPGLRAGLAASIAGSSIINKMLLANIDPFGATPFIDPDLDSVDGYSEKCV 770

Query: 720  MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLL 779
            MNNYFGIGLDAKISL+FNNKR+EHPEKCRSRTKN+MWYGVLGT+ELL R+YKNLEQ+V L
Sbjct: 771  MNNYFGIGLDAKISLEFNNKREEHPEKCRSRTKNLMWYGVLGTRELLQRSYKNLEQRVQL 830

Query: 780  ECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQM 839
            ECDG+ IPLPSLQGIAVLNIPSYAGGTNFWGGTKEDD FAAPSFDDKILEVVA+F SMQM
Sbjct: 831  ECDGQYIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDIFAAPSFDDKILEVVAIFDSMQM 890

Query: 840  AVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDR 899
            AVSRVI+LQHHRIAQCRTVKI+I GDEGVPVQVDGEAWVQPPG I+IVHKNRAQ LTRDR
Sbjct: 891  AVSRVIKLQHHRIAQCRTVKITIFGDEGVPVQVDGEAWVQPPGIIKIVHKNRAQMLTRDR 950

Query: 900  AFESTLKSWEDKQKCELPRPPSCSL----HPEMLSEEEATQMDQFGQAAGVLIHSIREIA 955
            AFESTLKSWEDKQKC+  +P   +     H   L+ EE +QM    QAA  LI  I + A
Sbjct: 951  AFESTLKSWEDKQKCDSGKPVLRTHLYIHHAIDLATEEVSQMQLCSQAAEELITRICDAA 1010

Query: 956  QSHRDMEQELAHAVNASSKSMDRVYGKPRTTEGLNCSFVLEMVNNFRALRSETELLLSGK 1015
              H  +EQELAHAVNA S ++++    PR  E L      E+  N +AL +ETE LL G+
Sbjct: 1011 TIHCLLEQELAHAVNACSHALNKA--NPRCPESLTRDTATEIAINVKALYNETESLLVGR 1068

Query: 1016 MALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDLAKR-SRSGKFR 1074
            + LQL+ P +E++ +AL  ++ +L++L + PWL     P ++E   +D  KR +RS  FR
Sbjct: 1069 VPLQLESPHEERVSNALHSVEVELQKLTEIPWLYYILHPNEDEEPPMDCTKRNNRSTVFR 1128

Query: 1075 LVTKFKKEKNNKNK 1088
            +V KFKKEK  K K
Sbjct: 1129 IVPKFKKEKVQKQK 1142


>gi|62000702 diacylglycerol kinase kappa [Homo sapiens]
          Length = 1271

 Score =  766 bits (1978), Expect = 0.0
 Identities = 456/1117 (40%), Positives = 640/1117 (57%), Gaps = 109/1117 (9%)

Query: 10   IIKEGMLTKQNNSFQRSKRRYFKLRGRTLYYAKTAKSIIFDEVDLTDASVAESSTKNVNN 69
            I+KEG + K  NSF+R K RYF ++G+ LY+A       F+ +DL+ A+VAESS +N+ +
Sbjct: 217  ILKEGPMLKNCNSFKRWKLRYFLVQGQKLYFAHHPAFAHFETIDLSQATVAESSCRNLCH 276

Query: 70   SFTVITPCRKLILCADNRKEMEDWIAALKTVQNREHFE-PTQYSMDHFSGMHNWYACSHA 128
            SF VITP RK+ L A NRK+ME+WI  +KT+Q  E ++ P   +     GMH WY+    
Sbjct: 277  SFCVITPQRKITLAAPNRKDMEEWINIIKTIQQGEIYKIPAAENNPFLVGMHCWYSSYSH 336

Query: 129  RPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGI 188
            R  +CNVCRE++  ++   + CEVCK K+H+ CA+RA+ +CKW TL SI  D++  AD +
Sbjct: 337  RTQHCNVCRESIPALSRDAIICEVCKVKSHRLCALRASKDCKWNTL-SITDDLLLPADEV 395

Query: 189  AMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCK 248
             MPHQW+EGN+PVS++C VC ++CGS  RLQD+RCLWC + VH  C+     +C     +
Sbjct: 396  NMPHQWVEGNMPVSSQCAVCHESCGSYQRLQDFRCLWCNSTVHDDCRRRFSKECCFRSHR 455

Query: 249  VSVIPPTALNSIDSDG-------FWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQL 301
             SVIPPTAL+    DG       FW      +C+ PLL+F+NSKSGD+QG+ FLR+FKQ 
Sbjct: 456  SSVIPPTALSDPKGDGQLVVSSDFWNLDWSSACSCPLLIFINSKSGDHQGIVFLRKFKQY 515

Query: 302  LNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLP 361
            LNP+QVFDL+ GGP  GL +F+ F  FRILVCGGDGSV WVLS ID+  LH++CQL V+P
Sbjct: 516  LNPSQVFDLLKGGPEAGLSMFKNFARFRILVCGGDGSVSWVLSLIDAFGLHEKCQLAVIP 575

Query: 362  LGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMAYEAKLPRQASSSTVT 421
            LGTGNDLARVLGWG+  +       IL ++E+AS ++LDRWSVM  E   PRQ       
Sbjct: 576  LGTGNDLARVLGWGAFWNKSKSPLDILNRVEQASVRILDRWSVMIRET--PRQTPLLKGQ 633

Query: 422  EDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVVISSAKVLCETVKDFVARVGKAYEKT 481
             +          + + +S A  L+KIL +   + +I + + LC  V+DFV  + KA+ + 
Sbjct: 634  VEMDVPRFEAAAIQHLESAATELNKILKAKYPTEMIIATRFLCSAVEDFVVDIVKAWGQI 693

Query: 482  TESSEESEVMAKKCSVLKEKLDSLLKTLDDESQASSSLPNPPPTIAEEAEDGDGSGSICG 541
             +++     +  K  ++ ++L  L+  L +E+ A+S+  +     A E  D         
Sbjct: 694  KQNNTAIVSVILKSDLMYDRLSVLIDVLAEEAAATSAEKS-----ATEYAD--------S 740

Query: 542  STGDRLVASACPARPQIFRPREQLMLRANSLKKAIRQIIEHTEKAVDEQNAQTQEQEGF- 600
            S  DR      P    I + + +L  +A SL+K+++ II   E+A+DE++ QT   + F 
Sbjct: 741  SKADR--KPFIPQIDHIAKCKLELATKAQSLQKSLKLIIFQVEQALDEESRQTISVKNFS 798

Query: 601  -VLGLSESEEKMDHRVCPPLSHSESFGVPKGRSQRKVSKSPCEKLISKGSLSLGSSASLP 659
                L +  E ++               P+ RS+R             G+LS  SS    
Sbjct: 799  STFFLEDDPEDINQT------------SPRRRSRR-------------GTLSSISSL--- 830

Query: 660  PQPGSRDGLPALNTKILYPNVRAGMSGSLPGGSVISRLLINADPFNSEPETLEYYTEKCV 719
                  + L  LN                             D  +  PE++  + EKCV
Sbjct: 831  ----KSEDLDNLN----------------------------LDHLHFTPESIR-FKEKCV 857

Query: 720  MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLL 779
            MNNYFGIGLDAKISLDFN +RDEHP +  SR KN MWYG+LGTKELL R+Y+ LE++V L
Sbjct: 858  MNNYFGIGLDAKISLDFNTRRDEHPGQYNSRLKNKMWYGLLGTKELLQRSYRKLEERVHL 917

Query: 780  ECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQM 839
            ECDG  I LP+LQGI VLNI SYAGG NFWG       + AP+ DD  LEVVA+FGS+QM
Sbjct: 918  ECDGETISLPNLQGIVVLNITSYAGGINFWGSNTATTEYEAPAIDDGKLEVVAIFGSVQM 977

Query: 840  AVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTLTRDR 899
            A+SR+I L HHRIAQC  V I+I G+EG+PVQVDGEAW+Q PG I+I +KN AQ LTRDR
Sbjct: 978  AMSRIINLHHHRIAQCHEVMITIDGEEGIPVQVDGEAWIQRPGLIKIRYKNAAQMLTRDR 1037

Query: 900  AFESTLKSWEDKQKCELPRPPSCSL----HPEMLSEEEATQMDQFGQAAGVLIHSIREIA 955
             FE+++K WE K   E+   P   L      E LS+EE  QM    + A  LI  + +++
Sbjct: 1038 DFENSMKMWEYKH-TEIQAAPQPQLDFQDSQESLSDEEYAQMQHLARLAENLISKLNDLS 1096

Query: 956  QSHRDMEQELAHAVNASSKSM-DRVYGKPR----------TTEGLNCSFVLEMVNNFRAL 1004
            + H+ +   L  +VNAS+  + D  YG+              E L+ +  +++  + + L
Sbjct: 1097 KIHQHV-SVLMGSVNASANILNDIFYGQDSGNEMGAASCIPIETLSRNDAVDVTFSLKGL 1155

Query: 1005 RSETELLLSGKMALQLDPPQKEQLGSALAEMDRQLRRLADTPWLCQSAEPGDEESVMLDL 1064
              +T   L  K+    +   +  L SAL  M+++ ++L++  W+     P +E+S   D 
Sbjct: 1156 YDDTTAFLDEKLLRSAE--DETALQSALDAMNKEFKKLSEIDWMNPIFVP-EEKSSDTDS 1212

Query: 1065 AKRSRSGKFRLVTKFKKEKNNKNKEAHSSLGAPVHLW 1101
                   KF  + K K E+  K K   S      +LW
Sbjct: 1213 RSLRLKIKFPKLGKKKVEEERKPKSGQSVQSFIGNLW 1249


>gi|22027634 diacylglycerol kinase, beta isoform 2 [Homo sapiens]
          Length = 773

 Score =  210 bits (534), Expect = 7e-54
 Identities = 120/330 (36%), Positives = 154/330 (46%), Gaps = 55/330 (16%)

Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
           G H W      +P YCN+C   L GV   GL C  CK+  H+RC  RA  +C  T + S 
Sbjct: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302

Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
               +       M H W+EGN P   KC  C KT      L    C+WC+  +H  C   
Sbjct: 303 RNTDV-------MHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353

Query: 238 LLTKCPLGLCKVSVIPPTAL---------------------------------------- 257
           L  +C  G  K  ++PPT +                                        
Sbjct: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413

Query: 258 -----NSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 312
                NS+  DG      P   T PLLVFVN KSG  QG +  R+F+ LLNP QV+ L  
Sbjct: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473

Query: 313 GGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVL 372
            GP  GL  F+    FR+L CGGDG+VGWVL  I+  N+ K   + +LPLGTGNDLAR L
Sbjct: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533

Query: 373 GWGSACDDDTQLPQILEKLERASTKMLDRW 402
            WG   + +  L +IL+ +E ++  MLDRW
Sbjct: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562



 Score =  127 bits (320), Expect = 5e-29
 Identities = 74/188 (39%), Positives = 104/188 (55%), Gaps = 27/188 (14%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           ++NNYF IG+DA I+  F+  R++HPEK  SR KN  WY   GT E    T K L + V 
Sbjct: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641

Query: 779 LECDGRPIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 814
           +ECDG  I L   SL+GIA+LNIPS  GG+N WG +K                      +
Sbjct: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701

Query: 815 DDTFAAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVD 873
           +  FA+    D++LEVV + G+M+M  +   ++    R+AQC  V I     + +P+Q+D
Sbjct: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759

Query: 874 GEAWVQPP 881
           GE W+Q P
Sbjct: 760 GEPWMQTP 767


>gi|22027632 diacylglycerol kinase, beta isoform 1 [Homo sapiens]
          Length = 804

 Score =  210 bits (534), Expect = 7e-54
 Identities = 120/330 (36%), Positives = 154/330 (46%), Gaps = 55/330 (16%)

Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
           G H W      +P YCN+C   L GV   GL C  CK+  H+RC  RA  +C  T + S 
Sbjct: 243 GQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCVARAPPSCIKTYVKSK 302

Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
               +       M H W+EGN P   KC  C KT      L    C+WC+  +H  C   
Sbjct: 303 RNTDV-------MHHYWVEGNCPT--KCDKCHKTVKCYQGLTGLHCVWCQITLHNKCASH 353

Query: 238 LLTKCPLGLCKVSVIPPTAL---------------------------------------- 257
           L  +C  G  K  ++PPT +                                        
Sbjct: 354 LKPECDCGPLKDHILPPTTICPVVLQTLPTSGVSVPEERQSTVKKEKSGSQQPNKVIDKN 413

Query: 258 -----NSIDSDGFWKASCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMN 312
                NS+  DG      P   T PLLVFVN KSG  QG +  R+F+ LLNP QV+ L  
Sbjct: 414 KMQRANSVTVDGQGLQVTPVPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSG 473

Query: 313 GGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVL 372
            GP  GL  F+    FR+L CGGDG+VGWVL  I+  N+ K   + +LPLGTGNDLAR L
Sbjct: 474 NGPMPGLNFFRDVPDFRVLACGGDGTVGWVLDCIEKANVGKHPPVAILPLGTGNDLARCL 533

Query: 373 GWGSACDDDTQLPQILEKLERASTKMLDRW 402
            WG   + +  L +IL+ +E ++  MLDRW
Sbjct: 534 RWGGGYEGE-NLMKILKDIENSTEIMLDRW 562



 Score =  139 bits (351), Expect = 1e-32
 Identities = 81/202 (40%), Positives = 113/202 (55%), Gaps = 27/202 (13%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           ++NNYF IG+DA I+  F+  R++HPEK  SR KN  WY   GT E    T K L + V 
Sbjct: 582 IINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVE 641

Query: 779 LECDGRPIPL--PSLQGIAVLNIPSYAGGTNFWGGTK----------------------E 814
           +ECDG  I L   SL+GIA+LNIPS  GG+N WG +K                      +
Sbjct: 642 IECDGVQIDLINISLEGIAILNIPSMHGGSNLWGESKKRRSHRRIEKKGSDKRTTVTDAK 701

Query: 815 DDTFAAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVD 873
           +  FA+    D++LEVV + G+M+M  +   ++    R+AQC  V I     + +P+Q+D
Sbjct: 702 ELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSCVVIRT--SKSLPMQID 759

Query: 874 GEAWVQPPGYIRIVHKNRAQTL 895
           GE W+Q P  I+I HKN+A  L
Sbjct: 760 GEPWMQTPCTIKITHKNQAPML 781


>gi|124256476 diacylglycerol kinase gamma isoform 1 [Homo sapiens]
          Length = 791

 Score =  207 bits (528), Expect = 4e-53
 Identities = 122/301 (40%), Positives = 152/301 (50%), Gaps = 28/301 (9%)

Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
           G H W      +PTYCN C   L GV   GL C  CK+  H+RC  R    C  T   + 
Sbjct: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKA- 328

Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
                    G  M H W+EGN   S KC  C K+      +    C+WC+   H  C+  
Sbjct: 329 ------KRSGEVMQHAWVEGNS--SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE-- 378

Query: 238 LLTKCPLGLCKVSVIPPTALNSID-------SDGFWKAS---------CPPSCTSPLLVF 281
           L T C  G  +  ++ PT++  I        SDG   A           P   T PLLV 
Sbjct: 379 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438

Query: 282 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGW 341
           VN KSG  QG + LR+F  LLNP QVF+L NGGP  GL  F+    FR+L CGGDG+VGW
Sbjct: 439 VNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGW 498

Query: 342 VLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 401
           +L  ID  N  K   + VLPLGTGNDLAR L WG   +  + L +IL+ +E++   MLDR
Sbjct: 499 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 557

Query: 402 W 402
           W
Sbjct: 558 W 558



 Score =  140 bits (354), Expect = 5e-33
 Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 21/193 (10%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           +MNNYF IG+DA I+  F+  R++HPEK  SR KN +WY   GT E    T K L   + 
Sbjct: 578 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 637

Query: 779 LECDGRPIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDT----------------FAA 820
           LECDG  + L +  L+GIA+LNIPS  GGTN WG  K++                  F  
Sbjct: 638 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 697

Query: 821 PSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQ 879
               D++LEVV + G+M+M  +   ++    R+AQC +V  +I  ++ +P+QVDGE W+Q
Sbjct: 698 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 755

Query: 880 PPGYIRIVHKNRA 892
           P   I+I HKN+A
Sbjct: 756 PCCTIKITHKNQA 768


>gi|41872494 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score =  206 bits (523), Expect = 1e-52
 Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%)

Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
           G H W      RP YCN+C  ++ G+   GLSC +CK+  H +CA++A   C+ +T A  
Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261

Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
            KDI     G+   H W+ G    S +C  C K       L    C+WC   +H  C ++
Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314

Query: 238 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 275
           +  +C  GL +  ++PP+++  S+ + G  + +                      P   T
Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374

Query: 276 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 335
            PLLVFVN KSG  QG + L +F+ +LNP QVF+L+  GP +GLRLF+     RILVCGG
Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434

Query: 336 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 395
           DG+VGW+L  ID  NL     + VLPLGTGNDLAR L WG   +    L +IL+ LE + 
Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493

Query: 396 TKMLDRWSV 404
              +DRWSV
Sbjct: 494 VVHMDRWSV 502



 Score =  126 bits (317), Expect = 1e-28
 Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           ++NNYF IG+DA I+  F+  R+++PEK  SR KN +WY    T E +  T K LE+ + 
Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579

Query: 779 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 818
           +E  G+P+ L   SL+GIAVLNIPS  GG+N WG T+    D +                
Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639

Query: 819 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 872
                  P   DK LEVV + G+++M  +   ++    R+A+C   +I+    + +P+Q+
Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697

Query: 873 DGEAWVQPPGYIRIVHKNRAQTL 895
           DGE W+Q P  I+I HKN+   L
Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720


>gi|41393587 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score =  206 bits (523), Expect = 1e-52
 Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%)

Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
           G H W      RP YCN+C  ++ G+   GLSC +CK+  H +CA++A   C+ +T A  
Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261

Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
            KDI     G+   H W+ G    S +C  C K       L    C+WC   +H  C ++
Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314

Query: 238 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 275
           +  +C  GL +  ++PP+++  S+ + G  + +                      P   T
Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374

Query: 276 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 335
            PLLVFVN KSG  QG + L +F+ +LNP QVF+L+  GP +GLRLF+     RILVCGG
Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434

Query: 336 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 395
           DG+VGW+L  ID  NL     + VLPLGTGNDLAR L WG   +    L +IL+ LE + 
Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493

Query: 396 TKMLDRWSV 404
              +DRWSV
Sbjct: 494 VVHMDRWSV 502



 Score =  126 bits (317), Expect = 1e-28
 Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           ++NNYF IG+DA I+  F+  R+++PEK  SR KN +WY    T E +  T K LE+ + 
Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579

Query: 779 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 818
           +E  G+P+ L   SL+GIAVLNIPS  GG+N WG T+    D +                
Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639

Query: 819 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 872
                  P   DK LEVV + G+++M  +   ++    R+A+C   +I+    + +P+Q+
Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697

Query: 873 DGEAWVQPPGYIRIVHKNRAQTL 895
           DGE W+Q P  I+I HKN+   L
Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720


>gi|31542504 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score =  206 bits (523), Expect = 1e-52
 Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%)

Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
           G H W      RP YCN+C  ++ G+   GLSC +CK+  H +CA++A   C+ +T A  
Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261

Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
            KDI     G+   H W+ G    S +C  C K       L    C+WC   +H  C ++
Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314

Query: 238 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 275
           +  +C  GL +  ++PP+++  S+ + G  + +                      P   T
Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374

Query: 276 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 335
            PLLVFVN KSG  QG + L +F+ +LNP QVF+L+  GP +GLRLF+     RILVCGG
Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434

Query: 336 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 395
           DG+VGW+L  ID  NL     + VLPLGTGNDLAR L WG   +    L +IL+ LE + 
Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493

Query: 396 TKMLDRWSV 404
              +DRWSV
Sbjct: 494 VVHMDRWSV 502



 Score =  126 bits (317), Expect = 1e-28
 Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           ++NNYF IG+DA I+  F+  R+++PEK  SR KN +WY    T E +  T K LE+ + 
Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579

Query: 779 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 818
           +E  G+P+ L   SL+GIAVLNIPS  GG+N WG T+    D +                
Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639

Query: 819 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 872
                  P   DK LEVV + G+++M  +   ++    R+A+C   +I+    + +P+Q+
Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697

Query: 873 DGEAWVQPPGYIRIVHKNRAQTL 895
           DGE W+Q P  I+I HKN+   L
Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720


>gi|41872500 diacylglycerol kinase, alpha 80kDa [Homo sapiens]
          Length = 735

 Score =  206 bits (523), Expect = 1e-52
 Identities = 119/309 (38%), Positives = 165/309 (53%), Gaps = 32/309 (10%)

Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
           G H W      RP YCN+C  ++ G+   GLSC +CK+  H +CA++A   C+ +T A  
Sbjct: 204 GQHMWRPKRFPRPVYCNLCESSI-GLGKQGLSCNLCKYTVHDQCAMKALP-CEVSTYAKS 261

Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
            KDI     G+   H W+ G    S +C  C K       L    C+WC   +H  C ++
Sbjct: 262 RKDI-----GV-QSHVWVRGGCE-SGRCDRCQKKIRIYHSLTGLHCVWCHLEIHDDCLQA 314

Query: 238 LLTKCPLGLCKVSVIPPTALN-SIDSDGFWKASC---------------------PPSCT 275
           +  +C  GL +  ++PP+++  S+ + G  + +                      P   T
Sbjct: 315 VGHECDCGLLRDHILPPSSIYPSVLASGPDRKNSKTSQKTMDDLNLSTSEALRIDPVPNT 374

Query: 276 SPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGG 335
            PLLVFVN KSG  QG + L +F+ +LNP QVF+L+  GP +GLRLF+     RILVCGG
Sbjct: 375 HPLLVFVNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVPDSRILVCGG 434

Query: 336 DGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERAS 395
           DG+VGW+L  ID  NL     + VLPLGTGNDLAR L WG   +    L +IL+ LE + 
Sbjct: 435 DGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLRWGGGYEGQ-NLAKILKDLEMSK 493

Query: 396 TKMLDRWSV 404
              +DRWSV
Sbjct: 494 VVHMDRWSV 502



 Score =  126 bits (317), Expect = 1e-28
 Identities = 75/203 (36%), Positives = 112/203 (55%), Gaps = 28/203 (13%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           ++NNYF IG+DA I+  F+  R+++PEK  SR KN +WY    T E +  T K LE+ + 
Sbjct: 520 IINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFATSESIFSTCKKLEESLT 579

Query: 779 LECDGRPIPLP--SLQGIAVLNIPSYAGGTNFWGGTK--EDDTF---------------- 818
           +E  G+P+ L   SL+GIAVLNIPS  GG+N WG T+    D +                
Sbjct: 580 VEICGKPLDLSNLSLEGIAVLNIPSMHGGSNLWGDTRRPHGDIYGINQALGATAKVITDP 639

Query: 819 -----AAPSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQV 872
                  P   DK LEVV + G+++M  +   ++    R+A+C   +I+    + +P+Q+
Sbjct: 640 DILKTCVPDLSDKRLEVVGLEGAIEMGQIYTKLKNAGRRLAKCS--EITFHTTKTLPMQI 697

Query: 873 DGEAWVQPPGYIRIVHKNRAQTL 895
           DGE W+Q P  I+I HKN+   L
Sbjct: 698 DGEPWMQTPCTIKITHKNQMPML 720


>gi|4503313 diacylglycerol kinase epsilon [Homo sapiens]
          Length = 567

 Score =  189 bits (481), Expect = 1e-47
 Identities = 132/396 (33%), Positives = 191/396 (48%), Gaps = 41/396 (10%)

Query: 120 HNWYACS-HARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNN--CKWTTLAS 176
           H W      ++PTYC VC + +      G  C+ C  +  + C  +A     CK   L +
Sbjct: 60  HGWRDTDLFSQPTYCCVCAQHIL----QGAFCDCCGLRVDEGCLRKADKRFQCKEIMLKN 115

Query: 177 IGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKE 236
             K +       AMPH W+ GN+P+ + C VC + CG   +L D+RC+WC+  VH  C +
Sbjct: 116 DTKVLD------AMPHHWIRGNVPLCSYCMVCKQQCGCQPKLCDYRCIWCQKTVHDECMK 169

Query: 237 SLL--TKCPLGLCKVSVIPPTALNSID-------SDGFWKASCPPSCTSPLLVFVNSKSG 287
           + L   KC  G  K  +IPP+ L SI+       +D    AS      +PL++  NS+SG
Sbjct: 170 NSLKNEKCDFGEFKNLIIPPSYLTSINQMRKDKKTDYEVLASKLGKQWTPLIILANSRSG 229

Query: 288 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRL--FQKFDTFRILVCGGDGSVGWVLSE 345
            N G   L  F+ LLNP QVFD+    P   L+L     + + R+LVCGGDG+VGWVL  
Sbjct: 230 TNMGEGLLGEFRILLNPVQVFDVTKTPPIKALQLCTLLPYYSARVLVCGGDGTVGWVLDA 289

Query: 346 IDSLNLHKQ----CQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 401
           +D + +  Q     Q+ VLPLGTGNDL+  LGWG+    +  + Q+L  +  A    LDR
Sbjct: 290 VDDMKIKGQEKYIPQVAVLPLGTGNDLSNTLGWGTGYAGEIPVAQVLRNVMEADGIKLDR 349

Query: 402 WSVMA-----YEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLSKILTSDQHSVV 456
           W V       Y  + P++    T+   FS   +    L +     AH  K   S   S +
Sbjct: 350 WKVQVTNKGYYNLRKPKE---FTMNNYFSVGPDALMALNFH----AHREK-APSLFSSRI 401

Query: 457 ISSAKVLCETVKDFVARVGKAYEKTTESSEESEVMA 492
           ++ A  L    KD + +  K   K  E   + E +A
Sbjct: 402 LNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVA 437



 Score =  133 bits (335), Expect = 9e-31
 Identities = 84/221 (38%), Positives = 117/221 (52%), Gaps = 10/221 (4%)

Query: 683 GMSGSLPGGSVISRLL----INADPFNSEPETLEYYT----EKCVMNNYFGIGLDAKISL 734
           G +G +P   V+  ++    I  D +  +     YY     ++  MNNYF +G DA ++L
Sbjct: 325 GYAGEIPVAQVLRNVMEADGIKLDRWKVQVTNKGYYNLRKPKEFTMNNYFSVGPDALMAL 384

Query: 735 DFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVLLECDGRPIPLPSLQGI 794
           +F+  R++ P    SR  N   Y   GTK+ L +  K+L +KV LE DG  + LPSL+GI
Sbjct: 385 NFHAHREKAPSLFSSRILNKAVYLFYGTKDCLVQECKDLNKKVELELDGERVALPSLEGI 444

Query: 795 AVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAVFGSMQMAVSRVIRLQHHRIAQ 854
            VLNI  + GG   W G   D+T+     DD +LEVV V+GS   A  +V      RI Q
Sbjct: 445 IVLNIGYWGGGCRLWEG-MGDETYPLARHDDGLLEVVGVYGSFHCAQIQVKLANPFRIGQ 503

Query: 855 CRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQTL 895
             TV++ IL    +P+QVDGE W Q P  + I HK  A  L
Sbjct: 504 AHTVRL-ILKCSMMPMQVDGEPWAQGPCTVTITHKTHAMML 543


>gi|124256474 diacylglycerol kinase gamma isoform 2 [Homo sapiens]
          Length = 766

 Score =  164 bits (414), Expect = 6e-40
 Identities = 106/301 (35%), Positives = 134/301 (44%), Gaps = 53/301 (17%)

Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
           G H W      +PTYCN C   L GV   GL C  CK+  H+RC  R    C  T   + 
Sbjct: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTYCKYTVHERCVSRNIPGCVKTYSKA- 328

Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
                    G  M H W+EGN   S KC  C K+      +    C+WC+   H  C+  
Sbjct: 329 ------KRSGEVMQHAWVEGNS--SVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCE-- 378

Query: 238 LLTKCPLGLCKVSVIPPTALNSID-------SDGFWKAS---------CPPSCTSPLLVF 281
           L T C  G  +  ++ PT++  I        SDG   A           P   T PLLV 
Sbjct: 379 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 438

Query: 282 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGW 341
           VN KSG  QG +                         L  F+    FR+L CGGDG+VGW
Sbjct: 439 VNPKSGGRQGER-------------------------LNFFRDTPDFRVLACGGDGTVGW 473

Query: 342 VLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 401
           +L  ID  N  K   + VLPLGTGNDLAR L WG   +  + L +IL+ +E++   MLDR
Sbjct: 474 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 532

Query: 402 W 402
           W
Sbjct: 533 W 533



 Score =  140 bits (354), Expect = 5e-33
 Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 21/193 (10%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           +MNNYF IG+DA I+  F+  R++HPEK  SR KN +WY   GT E    T K L   + 
Sbjct: 553 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 612

Query: 779 LECDGRPIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDT----------------FAA 820
           LECDG  + L +  L+GIA+LNIPS  GGTN WG  K++                  F  
Sbjct: 613 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 672

Query: 821 PSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQ 879
               D++LEVV + G+M+M  +   ++    R+AQC +V  +I  ++ +P+QVDGE W+Q
Sbjct: 673 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 730

Query: 880 PPGYIRIVHKNRA 892
           P   I+I HKN+A
Sbjct: 731 PCCTIKITHKNQA 743


>gi|124256482 diacylglycerol kinase gamma isoform 3 [Homo sapiens]
          Length = 752

 Score =  154 bits (388), Expect = 6e-37
 Identities = 108/301 (35%), Positives = 137/301 (45%), Gaps = 67/301 (22%)

Query: 118 GMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASI 177
           G H W      +PTYCN C   L GV   GL C                  CK+T     
Sbjct: 270 GRHAWTMKHFKKPTYCNFCHIMLMGVRKQGLCCTY----------------CKYT----- 308

Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
                       +  + +  N+P       C KT     R  ++         H  C+  
Sbjct: 309 ------------VHERCVSRNIPG------CVKTYSKAKRSGEF---------HRKCE-- 339

Query: 238 LLTKCPLGLCKVSVIPPTALNSID-------SDGFWKAS---------CPPSCTSPLLVF 281
           L T C  G  +  ++ PT++  I        SDG   A           P   T PLLV 
Sbjct: 340 LSTLCDGGELRDHILLPTSICPITRDRPGEKSDGCVSAKGELVMQYKIIPTPGTHPLLVL 399

Query: 282 VNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGW 341
           VN KSG  QG + LR+F  LLNP QVF+L NGGP  GL  F+    FR+L CGGDG+VGW
Sbjct: 400 VNPKSGGRQGERILRKFHYLLNPKQVFNLDNGGPTPGLNFFRDTPDFRVLACGGDGTVGW 459

Query: 342 VLSEIDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDR 401
           +L  ID  N  K   + VLPLGTGNDLAR L WG   +  + L +IL+ +E++   MLDR
Sbjct: 460 ILDCIDKANFAKHPPVAVLPLGTGNDLARCLRWGGGYEGGS-LTKILKDIEQSPLVMLDR 518

Query: 402 W 402
           W
Sbjct: 519 W 519



 Score =  140 bits (354), Expect = 5e-33
 Identities = 80/193 (41%), Positives = 112/193 (58%), Gaps = 21/193 (10%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           +MNNYF IG+DA I+  F+  R++HPEK  SR KN +WY   GT E    T K L   + 
Sbjct: 539 IMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIE 598

Query: 779 LECDGRPIPLPS--LQGIAVLNIPSYAGGTNFWGGTKEDDT----------------FAA 820
           LECDG  + L +  L+GIA+LNIPS  GGTN WG  K++                  F  
Sbjct: 599 LECDGVGVDLSNIFLEGIAILNIPSMYGGTNLWGENKKNRAVIRESRKGVTDPKELKFCV 658

Query: 821 PSFDDKILEVVAVFGSMQMA-VSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQ 879
               D++LEVV + G+M+M  +   ++    R+AQC +V  +I  ++ +P+QVDGE W+Q
Sbjct: 659 QDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCASV--TIRTNKLLPMQVDGEPWMQ 716

Query: 880 PPGYIRIVHKNRA 892
           P   I+I HKN+A
Sbjct: 717 PCCTIKITHKNQA 729


>gi|41872507 diacylglycerol kinase zeta isoform 2 [Homo sapiens]
          Length = 929

 Score =  151 bits (381), Expect = 4e-36
 Identities = 108/337 (32%), Positives = 145/337 (43%), Gaps = 56/337 (16%)

Query: 118 GMHNWYACS------HARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATN---N 168
           G H W+  +      +    YC V R     V+     C  CK   H  C  +       
Sbjct: 96  GEHIWFETNVSGDFCYVGEQYC-VARMLQKSVSRR--KCAACKIVVHTPCIEQLEKINFR 152

Query: 169 CKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWR-----C 223
           CK +   S  +++ E      + H W+        KC  C K                 C
Sbjct: 153 CKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISC 208

Query: 224 LWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL-------NSIDS---------- 262
            WCK   H+     +L +    C LG+    VIPPT +       N++ +          
Sbjct: 209 SWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFK 268

Query: 263 ---------DGFWKA----SCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFD 309
                    +G W+       P     PLLVFVN KSG NQG K ++ F   LNP QVFD
Sbjct: 269 RKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFD 328

Query: 310 LMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLA 369
           L  GGP   L +++K    RIL CGGDG+VGW+LS +D L L     + +LPLGTGNDLA
Sbjct: 329 LSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLA 388

Query: 370 RVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 406
           R L WG    D+  + +IL  +E  +   LDRW + A
Sbjct: 389 RTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 424



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 77/278 (27%), Positives = 126/278 (45%), Gaps = 23/278 (8%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           V NNYF +G DA ++L+F+  R+ +PEK  SR +N M+Y      + L  + K+L + + 
Sbjct: 447 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 506

Query: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833
           + CDG  +  P +Q      +  LNIP Y  GT  WG   E   F     DD  LEV+  
Sbjct: 507 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 565

Query: 834 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 893
             +M    +  +     R+ QCR V ++    + +PVQVDGE        IRI  +N+A 
Sbjct: 566 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 620

Query: 894 TLTRDRAFESTLKSWEDKQ------KCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVL 947
           T+ +     S      D+Q      + ++ R    S+H       +  Q+ +     G +
Sbjct: 621 TMVQKAKRRSAAPLHSDQQPVPEQLRIQVSR---VSMHDYEALHYDKEQLKEASVPLGTV 677

Query: 948 I---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 982
           +    S  E+ ++H +  Q+      A S +  ++  K
Sbjct: 678 VVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 715


>gi|41872527 diacylglycerol kinase zeta isoform 3 [Homo sapiens]
          Length = 895

 Score =  151 bits (381), Expect = 4e-36
 Identities = 108/337 (32%), Positives = 145/337 (43%), Gaps = 56/337 (16%)

Query: 118 GMHNWYACS------HARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATN---N 168
           G H W+  +      +    YC V R     V+     C  CK   H  C  +       
Sbjct: 62  GEHIWFETNVSGDFCYVGEQYC-VARMLQKSVSRR--KCAACKIVVHTPCIEQLEKINFR 118

Query: 169 CKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWR-----C 223
           CK +   S  +++ E      + H W+        KC  C K                 C
Sbjct: 119 CKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCRHCGKGFQQKFTFHSKEIVAISC 174

Query: 224 LWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL-------NSIDS---------- 262
            WCK   H+     +L +    C LG+    VIPPT +       N++ +          
Sbjct: 175 SWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFK 234

Query: 263 ---------DGFWKA----SCPPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFD 309
                    +G W+       P     PLLVFVN KSG NQG K ++ F   LNP QVFD
Sbjct: 235 RKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFD 294

Query: 310 LMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEIDSLNLHKQCQLGVLPLGTGNDLA 369
           L  GGP   L +++K    RIL CGGDG+VGW+LS +D L L     + +LPLGTGNDLA
Sbjct: 295 LSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLA 354

Query: 370 RVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 406
           R L WG    D+  + +IL  +E  +   LDRW + A
Sbjct: 355 RTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 390



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 77/278 (27%), Positives = 126/278 (45%), Gaps = 23/278 (8%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           V NNYF +G DA ++L+F+  R+ +PEK  SR +N M+Y      + L  + K+L + + 
Sbjct: 413 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 472

Query: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833
           + CDG  +  P +Q      +  LNIP Y  GT  WG   E   F     DD  LEV+  
Sbjct: 473 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 531

Query: 834 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 893
             +M    +  +     R+ QCR V ++    + +PVQVDGE        IRI  +N+A 
Sbjct: 532 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 586

Query: 894 TLTRDRAFESTLKSWEDKQ------KCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVL 947
           T+ +     S      D+Q      + ++ R    S+H       +  Q+ +     G +
Sbjct: 587 TMVQKAKRRSAAPLHSDQQPVPEQLRIQVSR---VSMHDYEALHYDKEQLKEASVPLGTV 643

Query: 948 I---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 982
           +    S  E+ ++H +  Q+      A S +  ++  K
Sbjct: 644 VVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 681


>gi|157688564 diacylglycerol kinase zeta isoform 4 [Homo sapiens]
          Length = 1117

 Score =  150 bits (379), Expect = 7e-36
 Identities = 100/299 (33%), Positives = 133/299 (44%), Gaps = 47/299 (15%)

Query: 150 CEVCKFKAHKRCAVRATN---NCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCT 206
           C  CK   H  C  +       CK +   S  +++ E      + H W+        KC 
Sbjct: 319 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCR 374

Query: 207 VCDKTCGSVLRLQDWR-----CLWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL 257
            C K                 C WCK   H+     +L +    C LG+    VIPPT +
Sbjct: 375 HCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI 434

Query: 258 -------NSIDS-------------------DGFWKA----SCPPSCTSPLLVFVNSKSG 287
                  N++ +                   +G W+       P     PLLVFVN KSG
Sbjct: 435 LRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSG 494

Query: 288 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEID 347
            NQG K ++ F   LNP QVFDL  GGP   L +++K    RIL CGGDG+VGW+LS +D
Sbjct: 495 GNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLD 554

Query: 348 SLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 406
            L L     + +LPLGTGNDLAR L WG    D+  + +IL  +E  +   LDRW + A
Sbjct: 555 QLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 612



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 77/278 (27%), Positives = 126/278 (45%), Gaps = 23/278 (8%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           V NNYF +G DA ++L+F+  R+ +PEK  SR +N M+Y      + L  + K+L + + 
Sbjct: 635 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 694

Query: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833
           + CDG  +  P +Q      +  LNIP Y  GT  WG   E   F     DD  LEV+  
Sbjct: 695 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 753

Query: 834 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 893
             +M    +  +     R+ QCR V ++    + +PVQVDGE        IRI  +N+A 
Sbjct: 754 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 808

Query: 894 TLTRDRAFESTLKSWEDKQ------KCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVL 947
           T+ +     S      D+Q      + ++ R    S+H       +  Q+ +     G +
Sbjct: 809 TMVQKAKRRSAAPLHSDQQPVPEQLRIQVSR---VSMHDYEALHYDKEQLKEASVPLGTV 865

Query: 948 I---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 982
           +    S  E+ ++H +  Q+      A S +  ++  K
Sbjct: 866 VVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 903


>gi|41872522 diacylglycerol kinase zeta isoform 1 [Homo sapiens]
          Length = 945

 Score =  150 bits (379), Expect = 7e-36
 Identities = 100/299 (33%), Positives = 133/299 (44%), Gaps = 47/299 (15%)

Query: 150 CEVCKFKAHKRCAVRATN---NCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCT 206
           C  CK   H  C  +       CK +   S  +++ E      + H W+        KC 
Sbjct: 147 CAACKIVVHTPCIEQLEKINFRCKPSFRESGSRNVREPT---FVRHHWVHRRRQ-DGKCR 202

Query: 207 VCDKTCGSVLRLQDWR-----CLWCKAMVHTSCKESLLTK----CPLGLCKVSVIPPTAL 257
            C K                 C WCK   H+     +L +    C LG+    VIPPT +
Sbjct: 203 HCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWI 262

Query: 258 -------NSIDS-------------------DGFWKA----SCPPSCTSPLLVFVNSKSG 287
                  N++ +                   +G W+       P     PLLVFVN KSG
Sbjct: 263 LRARRPQNTLKASKKKKRASFKRKSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSG 322

Query: 288 DNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSEID 347
            NQG K ++ F   LNP QVFDL  GGP   L +++K    RIL CGGDG+VGW+LS +D
Sbjct: 323 GNQGAKIIQSFLWYLNPRQVFDLSQGGPKEALEMYRKVHNLRILACGGDGTVGWILSTLD 382

Query: 348 SLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSVMA 406
            L L     + +LPLGTGNDLAR L WG    D+  + +IL  +E  +   LDRW + A
Sbjct: 383 QLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDE-PVSKILSHVEEGNVVQLDRWDLHA 440



 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 77/278 (27%), Positives = 126/278 (45%), Gaps = 23/278 (8%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           V NNYF +G DA ++L+F+  R+ +PEK  SR +N M+Y      + L  + K+L + + 
Sbjct: 463 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIR 522

Query: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833
           + CDG  +  P +Q      +  LNIP Y  GT  WG   E   F     DD  LEV+  
Sbjct: 523 VVCDGMDL-TPKIQDLKPQCVVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGF 581

Query: 834 FGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNRAQ 893
             +M    +  +     R+ QCR V ++    + +PVQVDGE        IRI  +N+A 
Sbjct: 582 --TMTSLAALQVGGHGERLTQCREVVLTT--SKAIPVQVDGEPCKLAASRIRIALRNQA- 636

Query: 894 TLTRDRAFESTLKSWEDKQ------KCELPRPPSCSLHPEMLSEEEATQMDQFGQAAGVL 947
           T+ +     S      D+Q      + ++ R    S+H       +  Q+ +     G +
Sbjct: 637 TMVQKAKRRSAAPLHSDQQPVPEQLRIQVSR---VSMHDYEALHYDKEQLKEASVPLGTV 693

Query: 948 I---HSIREIAQSHRDMEQELAHAVNASSKSMDRVYGK 982
           +    S  E+ ++H +  Q+      A S +  ++  K
Sbjct: 694 VVPGDSDLELCRAHIERLQQEPDGAGAKSPTCQKLSPK 731


>gi|4758156 diacylglycerol kinase, iota [Homo sapiens]
          Length = 1065

 Score =  142 bits (358), Expect = 2e-33
 Identities = 101/299 (33%), Positives = 127/299 (42%), Gaps = 50/299 (16%)

Query: 150 CEVCKFKAHKRCAVRATN---NCKWTTLASIGKDIIEDADGIAMPHQWLEGNLPVSAKCT 206
           C VCK   H  C  +       CK T      +   E+     + H W+        KC 
Sbjct: 210 CAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENF----VRHHWVHRRRQ-EGKCK 264

Query: 207 VCDKTCGSVLRLQDWR-----CLWCKAMVHTSCKESLL----TKCPLGLCKVSVIPPTAL 257
            C K                 C WCK   H      +L      C LG     ++PPT +
Sbjct: 265 QCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWI 324

Query: 258 -------NSIDSDG-------------------------FWKASCPPSCTSPLLVFVNSK 285
                  NS+ +                           F           PLLVFVN K
Sbjct: 325 IKVKKPQNSLKASNRKKKRTSFKRKASKRGMEQENKGRPFVIKPISSPLMKPLLVFVNPK 384

Query: 286 SGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRILVCGGDGSVGWVLSE 345
           SG NQG K L+ F   LNP QVFDL   GP   L L++K    RIL CGGDG+VGW+LS 
Sbjct: 385 SGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSI 444

Query: 346 IDSLNLHKQCQLGVLPLGTGNDLARVLGWGSACDDDTQLPQILEKLERASTKMLDRWSV 404
           +D L L  Q  +GVLPLGTGNDLAR L WG    D+  + +IL ++E  +   LDRW++
Sbjct: 445 LDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDE-PVSKILCQVEDGTVVQLDRWNL 502



 Score =  103 bits (257), Expect = 1e-21
 Identities = 63/188 (33%), Positives = 98/188 (52%), Gaps = 14/188 (7%)

Query: 719 VMNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTKELLHRTYKNLEQKVL 778
           V NNYF +G DA ++L+F+  R+ +PEK  SR +N M+Y      + L R+ ++L + V 
Sbjct: 526 VFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVK 585

Query: 779 LECDGRPIPLPSLQG-----IAVLNIPSYAGGTNFWGGTKEDDTFAAPSFDDKILEVVAV 833
           + CDG  +  P +Q      I  LNIP Y  GT  WG   +   F     DD  +EV+  
Sbjct: 586 VVCDGTDL-TPKIQELKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVI-- 642

Query: 834 FGSMQMAVSRVIRLQHH--RIAQCRTVKISILGDEGVPVQVDGEAWVQPPGYIRIVHKNR 891
                MA    +++  H  R+ QCR  ++ +L  + +P+QVDGE     P  IRI  +N+
Sbjct: 643 --GFTMASLAALQVGGHGERLHQCR--EVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQ 698

Query: 892 AQTLTRDR 899
           A  + + +
Sbjct: 699 ANMVQKSK 706


>gi|40806175 diacylglycerol kinase, theta [Homo sapiens]
          Length = 942

 Score =  132 bits (332), Expect = 2e-30
 Identities = 78/180 (43%), Positives = 102/180 (56%), Gaps = 13/180 (7%)

Query: 271 PPSCTSPLLVFVNSKSGDNQGVKFLRRFKQLLNPAQVFDLMNGGPHLGLRLFQKFDTFRI 330
           P SC  PLLVFVN KSG  +G   L  F++LLNP QVFDL NGGP  GL LF +   FR+
Sbjct: 584 PDSC--PLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRV 641

Query: 331 LVCGGDGSVGWVLSEIDSLNLHKQC---QLGVLPLGTGNDLARVLGWGSACDDDTQLPQI 387
           LVCGGDG+VGWVL  ++       C    + +LPLGTGNDL RVL WG+    +     +
Sbjct: 642 LVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPF-SV 700

Query: 388 LEKLERASTKMLDRWSVM--AYEAKLPRQASSSTVTEDFSEDSEVQQILFYEDSVAAHLS 445
           L  ++ A   ++DRW+++  A+EA      S+   T D      VQ   +    + A LS
Sbjct: 701 LLSVDEADAVLMDRWTILLDAHEA-----GSAENDTADAEPPKIVQMSNYCGIGIDAELS 755



 Score =  119 bits (297), Expect = 2e-26
 Identities = 69/183 (37%), Positives = 109/183 (59%), Gaps = 6/183 (3%)

Query: 705 NSEPETLEYYTEKCV-MNNYFGIGLDAKISLDFNNKRDEHPEKCRSRTKNMMWYGVLGTK 763
           ++E +T +    K V M+NY GIG+DA++SLDF+  R+E P K  SR  N   Y  +G +
Sbjct: 726 SAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQ 785

Query: 764 ELLHRTYKNLEQKVLLECDGRPIPLPSLQGIAVLNIPSYAGGTNFWGGTKEDDTFAAPSF 823
           ++ H   ++L +++ L+ + + + LPS++G+  +NIPS+  G + W G+  D  F  P  
Sbjct: 786 KISHS--RSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLW-GSDSDTRFEKPRM 842

Query: 824 DDKILEVVAVFGSMQMAVSRVIRLQHHRIAQCRTVKISILGDEGVPVQVDGEAWVQPPGY 883
           DD +LEVV V G + M   +       RIAQ    ++++L  +  PVQVDGE WVQ PG+
Sbjct: 843 DDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLL--KATPVQVDGEPWVQAPGH 900

Query: 884 IRI 886
           + I
Sbjct: 901 MII 903



 Score = 87.4 bits (215), Expect = 7e-17
 Identities = 49/136 (36%), Positives = 65/136 (47%), Gaps = 11/136 (8%)

Query: 132 YCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGKDIIEDADGIAMP 191
           +C VCR+ L     H   CEVC+   H  C   A ++C+        +D  +D D     
Sbjct: 134 FCAVCRKVLEAPALH---CEVCELHLHPDCVPFACSDCR-----QCHQDGHQDHD--THH 183

Query: 192 HQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLLTKCPLGLCKVSV 251
           H W EGNLP  A+C VC KTCGS   L   RC WC    H+ C  +L  +C  G  +  V
Sbjct: 184 HHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLRSLV 243

Query: 252 IPPTALNSIDSDGFWK 267
           +PP  +  +   GF K
Sbjct: 244 LPPACVRLLPG-GFSK 258



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 28/123 (22%), Positives = 51/123 (41%), Gaps = 15/123 (12%)

Query: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIGK 179
           H++   +  +PT+C++C + + G+   G  C+VC F +H++C       C      S+  
Sbjct: 61  HSFRKVTLTKPTFCHLCSDFIWGLA--GFLCDVCNFMSHEKCLKHVRIPC-----TSVAP 113

Query: 180 DIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESLL 239
            ++     + + H +    L     C VC K    VL      C  C+  +H  C     
Sbjct: 114 SLVR----VPVAHCFGPRGLHKRKFCAVCRK----VLEAPALHCEVCELHLHPDCVPFAC 165

Query: 240 TKC 242
           + C
Sbjct: 166 SDC 168



 Score = 35.4 bits (80), Expect = 0.32
 Identities = 19/65 (29%), Positives = 28/65 (43%), Gaps = 1/65 (1%)

Query: 114 DHFSGMHNWYACSHARPTYCNVCREAL-SGVTSHGLSCEVCKFKAHKRCAVRATNNCKWT 172
           DH +  H+W   +      C VCR+   S     G+ CE C  +AH  C+      C + 
Sbjct: 178 DHDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFG 237

Query: 173 TLASI 177
            L S+
Sbjct: 238 RLRSL 242


>gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1
            [Homo sapiens]
          Length = 1849

 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 33/65 (50%), Positives = 45/65 (69%)

Query: 1097 PVHLWGTEEVAAWLEHLSLCEYKDIFTRHDIRGSELLHLERRDLKDLGVTKVGHMKRILC 1156
            PVHLW   +VA WLE L+L E+K+ F  ++I GS L +L++ DL DLGVT+VGH   I  
Sbjct: 1782 PVHLWTKPDVADWLESLNLGEHKEAFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIER 1841

Query: 1157 GIKEL 1161
             +K+L
Sbjct: 1842 ALKQL 1846


>gi|28557781 protein kinase C, eta [Homo sapiens]
          Length = 683

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 39/125 (31%), Positives = 55/125 (44%), Gaps = 3/125 (2%)

Query: 120 HNWYACSHARPTYCNVCREALSGV-TSHGLSCEVCKFKAHKRCAVRATNNCK-WTTLASI 177
           H + A    +PTYC+ CRE + GV    G  C+VC    HKRC       C     +  +
Sbjct: 172 HKFMATYLRQPTYCSHCREFIWGVFGKQGYQCQVCTCVVHKRCHHLIVTACTCQNNINKV 231

Query: 178 GKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKES 237
              I E   GI +PH++   N  V   C  C      ++R Q  +C  CK  VH  C+ +
Sbjct: 232 DSKIAEQRFGINIPHKFSIHNYKVPTFCDHCGSLLWGIMR-QGLQCKICKMNVHIRCQAN 290

Query: 238 LLTKC 242
           +   C
Sbjct: 291 VAPNC 295



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 5/58 (8%)

Query: 112 SMDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169
           ++ H   +HN+       PT+C+ C   L G+   GL C++CK   H RC      NC
Sbjct: 243 NIPHKFSIHNYKV-----PTFCDHCGSLLWGIMRQGLQCKICKMNVHIRCQANVAPNC 295


>gi|47157325 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 7/131 (5%)

Query: 115 HFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTL 174
           H+   H + A    +PT+C+VC++ + G+   G  C  C    HK+C  +    C  T  
Sbjct: 154 HYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAA 213

Query: 175 ASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSV---LRLQDWRCLWCKAMVH 231
            S      ++   I MPH++   N       T CD  CGS+   L  Q  +C  C   VH
Sbjct: 214 NSRDTIFQKERFNIDMPHRFKVHNY---MSPTFCDH-CGSLLWGLVKQGLKCEDCGMNVH 269

Query: 232 TSCKESLLTKC 242
             C+E +   C
Sbjct: 270 HKCREKVANLC 280


>gi|31377782 protein kinase C, delta [Homo sapiens]
          Length = 676

 Score = 64.3 bits (155), Expect = 6e-10
 Identities = 38/131 (29%), Positives = 57/131 (43%), Gaps = 7/131 (5%)

Query: 115 HFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNCKWTTL 174
           H+   H + A    +PT+C+VC++ + G+   G  C  C    HK+C  +    C  T  
Sbjct: 154 HYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAA 213

Query: 175 ASIGKDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSV---LRLQDWRCLWCKAMVH 231
            S      ++   I MPH++   N       T CD  CGS+   L  Q  +C  C   VH
Sbjct: 214 NSRDTIFQKERFNIDMPHRFKVHNY---MSPTFCDH-CGSLLWGLVKQGLKCEDCGMNVH 269

Query: 232 TSCKESLLTKC 242
             C+E +   C
Sbjct: 270 HKCREKVANLC 280


>gi|4885563 protein kinase C, epsilon [Homo sapiens]
          Length = 737

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 43/148 (29%), Positives = 60/148 (40%), Gaps = 9/148 (6%)

Query: 120 HNWYACSHARPTYCNVCREALSGVT-SHGLSCEVCKFKAHKRCAVRATNNCKWTTLASIG 178
           H + A    +PTYC+ CR+ + GV    G  C+VC    HKRC       C         
Sbjct: 170 HKFMATYLRQPTYCSHCRDFIWGVIGKQGYQCQVCTCVVHKRCHELIITKCAGLKKQETP 229

Query: 179 KDIIEDADGIAMPHQWLEGNLPVSAKCTVCDKTCGSVLRLQDWRCLWCKAMVHTSCKESL 238
             +      + MPH++   N  V   C  C      +LR Q  +C  CK  VH  C+ ++
Sbjct: 230 DQVGSQRFSVNMPHKFGIHNYKVPTFCDHCGSLLWGLLR-QGLQCKVCKMNVHRRCETNV 288

Query: 239 LTKCPL---GLCKV----SVIPPTALNS 259
              C +   G+ KV     V P    NS
Sbjct: 289 APNCGVDARGIAKVLADLGVTPDKITNS 316



 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 26/77 (33%), Positives = 37/77 (48%), Gaps = 7/77 (9%)

Query: 95  AALKTVQNREHFEPTQYS--MDHFSGMHNWYACSHARPTYCNVCREALSGVTSHGLSCEV 152
           A LK  +  +     ++S  M H  G+HN+       PT+C+ C   L G+   GL C+V
Sbjct: 221 AGLKKQETPDQVGSQRFSVNMPHKFGIHNYKV-----PTFCDHCGSLLWGLLRQGLQCKV 275

Query: 153 CKFKAHKRCAVRATNNC 169
           CK   H+RC      NC
Sbjct: 276 CKMNVHRRCETNVAPNC 292


>gi|120659787 protein kinase D2 isoform B [Homo sapiens]
          Length = 721

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 23/50 (46%), Positives = 30/50 (60%)

Query: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169
           H +   S+ RPT C  C++ L G+   GL C+ CKF  HKRCA R  N+C
Sbjct: 108 HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDC 157



 Score = 35.0 bits (79), Expect = 0.42
 Identities = 14/30 (46%), Positives = 16/30 (53%)

Query: 140 LSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169
           L G+   GL C+ C    HKRCA    NNC
Sbjct: 2   LFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 31


>gi|120659785 protein kinase D2 isoform A [Homo sapiens]
          Length = 878

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 23/50 (46%), Positives = 30/50 (60%)

Query: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169
           H +   S+ RPT C  C++ L G+   GL C+ CKF  HKRCA R  N+C
Sbjct: 265 HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDC 314



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 19/44 (43%), Positives = 24/44 (54%)

Query: 126 SHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169
           S+  P +C+ C E L G+   GL C+ C    HKRCA    NNC
Sbjct: 145 SYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 188


>gi|120659782 protein kinase D2 isoform A [Homo sapiens]
          Length = 878

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 23/50 (46%), Positives = 30/50 (60%)

Query: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169
           H +   S+ RPT C  C++ L G+   GL C+ CKF  HKRCA R  N+C
Sbjct: 265 HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDC 314



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 19/44 (43%), Positives = 24/44 (54%)

Query: 126 SHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169
           S+  P +C+ C E L G+   GL C+ C    HKRCA    NNC
Sbjct: 145 SYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 188


>gi|19923468 protein kinase D2 isoform A [Homo sapiens]
          Length = 878

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 23/50 (46%), Positives = 30/50 (60%)

Query: 120 HNWYACSHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169
           H +   S+ RPT C  C++ L G+   GL C+ CKF  HKRCA R  N+C
Sbjct: 265 HTFLIHSYTRPTVCQACKKLLKGLFRQGLQCKDCKFNCHKRCATRVPNDC 314



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 19/44 (43%), Positives = 24/44 (54%)

Query: 126 SHARPTYCNVCREALSGVTSHGLSCEVCKFKAHKRCAVRATNNC 169
           S+  P +C+ C E L G+   GL C+ C    HKRCA    NNC
Sbjct: 145 SYRAPAFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCAFSIPNNC 188


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 47,097,586
Number of Sequences: 37866
Number of extensions: 2223687
Number of successful extensions: 8156
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 138
Number of HSP's that attempted gapping in prelim test: 7675
Number of HSP's gapped (non-prelim): 472
length of query: 1170
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1057
effective length of database: 13,968,660
effective search space: 14764873620
effective search space used: 14764873620
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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