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Search of human proteins with 24475847
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
(642 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 1327 0.0
gi|38194229 kelch-like 17 [Homo sapiens] 258 1e-68
gi|14780904 kelch-like 1 protein [Homo sapiens] 254 2e-67
gi|40807500 kelch-like 20 [Homo sapiens] 254 2e-67
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 251 1e-66
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 251 1e-66
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 251 2e-66
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 251 2e-66
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 251 2e-66
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 250 3e-66
gi|166235129 kelch-like 3 [Homo sapiens] 249 4e-66
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 236 6e-62
gi|34101268 kelch-like 8 [Homo sapiens] 218 1e-56
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 218 2e-56
gi|11056006 kelch-like 12 [Homo sapiens] 209 6e-54
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 207 3e-53
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 207 3e-53
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 204 3e-52
gi|148664209 kelch-like 10 [Homo sapiens] 172 1e-42
gi|55925604 kelch-like 18 [Homo sapiens] 165 1e-40
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 154 3e-37
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 152 1e-36
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 150 3e-36
gi|8922854 kelch-like 26 [Homo sapiens] 150 5e-36
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 149 6e-36
gi|128485503 kelch-like 30 [Homo sapiens] 147 3e-35
gi|11545731 gigaxonin [Homo sapiens] 146 5e-35
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 146 7e-35
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 146 7e-35
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 143 4e-34
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 1327 bits (3435), Expect = 0.0
Identities = 642/642 (100%), Positives = 642/642 (100%)
Query: 1 MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEI 60
MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEI
Sbjct: 1 MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEI 60
Query: 61 FNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQV 120
FNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQV
Sbjct: 61 FNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQV 120
Query: 121 CGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEV 180
CGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEV
Sbjct: 121 CGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEV 180
Query: 181 MLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQ 240
MLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQ
Sbjct: 181 MLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQ 240
Query: 241 AEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNN 300
AEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNN
Sbjct: 241 AEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNN 300
Query: 301 TYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSG 360
TYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSG
Sbjct: 301 TYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSG 360
Query: 361 LGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVV 420
LGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVV
Sbjct: 361 LGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVV 420
Query: 421 GGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLK 480
GGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLK
Sbjct: 421 GGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLK 480
Query: 481 NCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWT 540
NCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWT
Sbjct: 481 NCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWT 540
Query: 541 LIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAG 600
LIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAG
Sbjct: 541 LIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAG 600
Query: 601 IATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF 642
IATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF
Sbjct: 601 IATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF 642
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 258 bits (659), Expect = 1e-68
Identities = 167/563 (29%), Positives = 272/563 (48%), Gaps = 49/563 (8%)
Query: 22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPE 81
++ +R+ G CD+ L V E+ AH+ VLA CSPY +F ++ +HV D++P+
Sbjct: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141
Query: 82 AVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFA 141
A++ L+ +AYTA++ + V+ + AA L+++ V+ C +LLS++D ++C+ R FA
Sbjct: 142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFA 201
Query: 142 SCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLP-RLKLEVMLEDNVCLPSNGKLYTKVIN 200
S LL Y+ +H + +++ EEF+ LP + LE++ D++ +PS ++Y V++
Sbjct: 202 DAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLS 261
Query: 201 WVQRSIWENGDSLEELMEEVQTLYYSADHKL----------------------LDGNLLD 238
WV+ + + LM+ V+ S D L L +LL
Sbjct: 262 WVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLLP 321
Query: 239 GQAEVFGSDDDHIQFVQKKPPRENGHKQI----SSSSTGCLSSPNATVQSPKHEWKIVAS 294
Q V G+ + +P R G + S + + W +VAS
Sbjct: 322 EQRGVLGTS-------RTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVAS 374
Query: 295 EKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPM 354
T AV + ++ V G + + + P + +P M
Sbjct: 375 MSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTW------------QPEVSM 422
Query: 355 QYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLM 414
RS LG A ++G L +AGGY+ CL + E Y+P T W+ +A M T R ++A L
Sbjct: 423 GTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLD 482
Query: 415 GQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPY 474
G LY VGG + S L+ E Y+ ++ W PV + + R +AGV L G LY+ GG+D
Sbjct: 483 GNLYAVGGYDS-SSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGND-- 539
Query: 475 GQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNP 534
G L + + + P W S AP+NIRR + + G+LY +GG + + LN++E+YNP
Sbjct: 540 GTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNP 599
Query: 535 ENNTWTLIAPMNVARRGAGVAVL 557
N W + M R GVAVL
Sbjct: 600 RTNKWVAASCMFTRRSSVGVAVL 622
Score = 190 bits (482), Expect = 4e-48
Identities = 107/264 (40%), Positives = 145/264 (54%), Gaps = 3/264 (1%)
Query: 370 LIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDD 429
L A GG + E Y+ TD W +A M T RAR +A + +LY VGG +G SD
Sbjct: 344 LFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSD- 402
Query: 430 LSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVT 489
L+ E YD + W P + T R GV AL+G LY GG D G L + + +DP+T
Sbjct: 403 LATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYD--GASCLNSAERYDPLT 460
Query: 490 KLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVAR 549
WTS A ++ RR V L G LY +GG +S + L TVE+Y P+ N W+ +A M R
Sbjct: 461 GTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRR 520
Query: 550 RGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIY 609
AGVAVL G L+V GG DG+ ++ VE Y P W+ + M RS + + +Y
Sbjct: 521 SSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLY 580
Query: 610 AVGGFDGNEFLNTVEVYNLESNEW 633
AVGG DG+ LN++E YN +N+W
Sbjct: 581 AVGGNDGSSSLNSIEKYNPRTNKW 604
Score = 162 bits (410), Expect = 9e-40
Identities = 90/254 (35%), Positives = 134/254 (52%), Gaps = 3/254 (1%)
Query: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQM 410
++ M R+ +G A + +L A GGY+ L TVE Y+P T+ W M T R+ +
Sbjct: 372 VASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGV 431
Query: 411 AVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGG 470
A L G LY GG +G S L+ E YD W V + T R V L+G LY VGG
Sbjct: 432 AALHGLLYSAGGYDGASC-LNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGG 490
Query: 471 SDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVE 530
D L + ++P +W+ A + RR + V L G LY+ GG + +CLN+VE
Sbjct: 491 YD--SSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVE 548
Query: 531 RYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMG 590
RY+P+ W +APMN+ R + ++G L+ GG DGS +++ +E Y+P N+W
Sbjct: 549 RYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAAS 608
Query: 591 NMTSPRSNAGIATV 604
M + RS+ G+A +
Sbjct: 609 CMFTRRSSVGVAVL 622
Score = 123 bits (309), Expect = 5e-28
Identities = 68/188 (36%), Positives = 97/188 (51%), Gaps = 3/188 (1%)
Query: 449 LRTNRCNAGVCALNGK-LYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAV 507
L T+R C G L+ VGG + G +C+ +D T W A ++ RR + V
Sbjct: 327 LGTSRTRPRRCEGAGPVLFAVGGGSLFAIHG--DCEAYDTRTDRWHVVASMSTRRARVGV 384
Query: 508 CELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGF 567
+G LY +GG + + L TVE Y+P NTW M R GVA L+G L+ GG+
Sbjct: 385 AAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGY 444
Query: 568 DGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYN 627
DG+ ++ E YDP W + M++ R +AT+ +YAVGG+D + L TVE Y
Sbjct: 445 DGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYE 504
Query: 628 LESNEWSP 635
+ N WSP
Sbjct: 505 PQVNVWSP 512
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 254 bits (648), Expect = 2e-67
Identities = 174/596 (29%), Positives = 287/596 (48%), Gaps = 53/596 (8%)
Query: 16 ESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKF 75
E + K+ + K Q CDV L V ++ AHR VL+ S Y +F SD +K
Sbjct: 196 EQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKM 255
Query: 76 DDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
+ ++P A+ L+ +AYT L+ ++ ++++ +AA L++ +V +VC +L+ + ++C+
Sbjct: 256 EGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCL 315
Query: 136 SYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPSNGKL 194
R FA G L+ +Y E+++++ +EFL LP +L +L D+V +P +
Sbjct: 316 GIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETI 375
Query: 195 YTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFV 254
+ ++ WV+ + + L L+ ++ LL Q + ++H F
Sbjct: 376 FHALMMWVKYDMQSRCNDLSMLLAFIRL------------PLLPPQ--ILADLENHALF- 420
Query: 255 QKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCV 314
K E + + L +QSP+ + K++ T + +D
Sbjct: 421 --KNDLECQKLILEAMKYHLLPERRTLMQSPRTK-----PRKSTVGTLYAVGGMDN---- 469
Query: 315 IFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAG 374
T+ K ++++ + I+ M M R G A ++ KL G
Sbjct: 470 ---------NKGATTIEK------YDLRTNLWIQAGM--MNGRRLQFGVAVIDDKLFVIG 512
Query: 375 GYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGE 434
G + + L TVECYNP T W+ L PM T R + VL G +Y VGG +G S L+ E
Sbjct: 513 GRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSY-LNTVE 571
Query: 435 MYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTS 494
+D W V + R GV ALNGKLY VGG D G L + + +DP T W
Sbjct: 572 RWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRD--GSSCLSSMEYYDPHTNKWNM 629
Query: 495 CAPLNIRRHQSAVCELGGYLYIIGGAE---SWNC---LNTVERYNPENNTWTLIAPMNVA 548
CAP+ RR V G+LY +GG + S +C L+ VERY+P+ +TWT++AP+++
Sbjct: 630 CAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMP 689
Query: 549 RRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATV 604
R GV +L +L+ GG+DG ++ +E YDP NEW M ++ R+ A + +
Sbjct: 690 RDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVI 745
Score = 186 bits (472), Expect = 6e-47
Identities = 99/273 (36%), Positives = 149/273 (54%), Gaps = 9/273 (3%)
Query: 368 GKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHS 427
G L A GG + + T+E Y+ T+ W M R +F +AV+ +L+V+GG +G
Sbjct: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLK 518
Query: 428 DDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDP 487
L+ E Y+ W +P + T+R GV L G +Y VGG D G L + +DP
Sbjct: 519 T-LNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHD--GWSYLNTVERWDP 575
Query: 488 VTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNV 547
++ WT A ++I R V L G LY +GG + +CL+++E Y+P N W + APM
Sbjct: 576 QSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCK 635
Query: 548 ARRGAGVAVLNGKLFVCGGFDGSHAISC------VEMYDPTRNEWKMMGNMTSPRSNAGI 601
R G GVA +G L+ GG D + C VE YDP + W M+ ++ PR G+
Sbjct: 636 RRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGV 695
Query: 602 ATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
+G+ +YAVGG+DG +LNT+E Y+ ++NEW+
Sbjct: 696 CLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWT 728
Score = 171 bits (434), Expect = 1e-42
Identities = 90/240 (37%), Positives = 135/240 (56%), Gaps = 10/240 (4%)
Query: 401 MRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCA 460
M++PR + + + + G LY VGG + + + E YD + WI + R GV
Sbjct: 446 MQSPRTKPRKSTV-GTLYAVGGMDNNKGATTI-EKYDLRTNLWIQAGMMNGRRLQFGVAV 503
Query: 461 LNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520
++ KL+++GG D G K L + ++P TK WT P++ RH V L G +Y +GG
Sbjct: 504 IDDKLFVIGGRD--GLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGH 561
Query: 521 ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYD 580
+ W+ LNTVER++P++ WT +A M++AR GVA LNGKL+ GG DGS +S +E YD
Sbjct: 562 DGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYD 621
Query: 581 PTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDG------NEFLNTVEVYNLESNEWS 634
P N+W M M R G+AT +YAVGG D + L+ VE Y+ +++ W+
Sbjct: 622 PHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWT 681
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 254 bits (648), Expect = 2e-67
Identities = 171/588 (29%), Positives = 283/588 (48%), Gaps = 45/588 (7%)
Query: 22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPE 81
+N LRK + CDV L V ++ AHR +L+ CSPY +F + + V D++
Sbjct: 58 INLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDER 117
Query: 82 AVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFA 141
A+E+L+++AYT+Q+ ++ V+ + AA L++ +++ C ++L ++D ++C+ R FA
Sbjct: 118 AMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFA 177
Query: 142 SCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVIN 200
LL D + Q + ++ E EEF+ LP +L +++ D + + S +++ V+
Sbjct: 178 DTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVMA 237
Query: 201 WVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPR 260
WV+ SI E L ++++ V+ S K L G + G + SD++ V +
Sbjct: 238 WVKYSIQERRPQLPQVLQHVRLPLLSP--KFLVGTV--GSDPLIKSDEECRDLVDE---- 289
Query: 261 ENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGR 320
+ + L +Q P+ K + AV G +C
Sbjct: 290 --------AKNYLLLPQERPLMQGPR-----TRPRKPIRCGEVLFAV--GGWC------- 327
Query: 321 NSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREE 380
S +S ++ Q +E + ++ M R G+G + ++ L A GG++
Sbjct: 328 --------SGDAISSVERYDPQTNEW--RMVASMSKRRCGVGVSVLDDLLYAVGGHDGSS 377
Query: 381 CLRTVECYNPHTDHWSF-LAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSN 439
L +VE Y+P T+ WS +AP T R +AVL G LY VGG +G S L+ E YD
Sbjct: 378 YLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSC-LNIVERYDPK 436
Query: 440 IDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLN 499
+ W V + T R V L G LY VGGSD G L + ++P W + AP+
Sbjct: 437 ENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSD--GTSPLNTVERYNPQENRWHTIAPMG 494
Query: 500 IRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNG 559
RR +Y +GG + L++ ERYNP N W+ + M R G G+AV+NG
Sbjct: 495 TRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNG 554
Query: 560 KLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNT 607
+L GGFDG+ + +E++DP N W++ G M R G+ + T
Sbjct: 555 QLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVIKMT 602
Score = 195 bits (495), Expect = 1e-49
Identities = 108/268 (40%), Positives = 147/268 (54%), Gaps = 4/268 (1%)
Query: 370 LIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDD 429
L A GG+ + + +VE Y+P T+ W +A M R ++VL LY VGG +G S
Sbjct: 320 LFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDG-SSY 378
Query: 430 LSCGEMYDSNIDDWIP-VPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPV 488
L+ E YD + W V T R + GV L G LY VGG D G L + +DP
Sbjct: 379 LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQD--GVSCLNIVERYDPK 436
Query: 489 TKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVA 548
WT A ++ RR AV LGG+LY +GG++ + LNTVERYNP+ N W IAPM
Sbjct: 437 ENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTR 496
Query: 549 RRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTI 608
R+ G AV ++ GG D + +S E Y+P N+W + MTS RS G+A V +
Sbjct: 497 RKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQL 556
Query: 609 YAVGGFDGNEFLNTVEVYNLESNEWSPY 636
AVGGFDG +L T+EV++ ++N W Y
Sbjct: 557 MAVGGFDGTTYLKTIEVFDPDANTWRLY 584
Score = 107 bits (266), Expect = 4e-23
Identities = 53/125 (42%), Positives = 79/125 (63%), Gaps = 1/125 (0%)
Query: 511 GGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGS 570
G L+ +GG S + +++VERY+P+ N W ++A M+ R G GV+VL+ L+ GG DGS
Sbjct: 317 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGS 376
Query: 571 HAISCVEMYDPTRNEWKMMGNMTSP-RSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLE 629
++ VE YDP N+W TS R++ G+A +G +YAVGG DG LN VE Y+ +
Sbjct: 377 SYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPK 436
Query: 630 SNEWS 634
N+W+
Sbjct: 437 ENKWT 441
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 251 bits (642), Expect = 1e-66
Identities = 170/603 (28%), Positives = 283/603 (46%), Gaps = 53/603 (8%)
Query: 9 FEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPH 68
F+ N E + K+ + Q CDV L + AHR VL+ S Y +F +D
Sbjct: 151 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA 210
Query: 69 GISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSR 128
+K + + P ++ L+ YAYT +L+ ++ ++ + S A L++ +V + C +L+ +
Sbjct: 211 RQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQ 270
Query: 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVC 187
+ ++C+ R+FA G + L Y EH +++ +EF+ LP ++ +L D++
Sbjct: 271 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMN 330
Query: 188 LPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSD 247
+P+ + ++ WV+ + + L +L+ ++ + L D + V D
Sbjct: 331 IPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQF------LADMENNVLFRD 384
Query: 248 DDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAV 307
D Q + + + + L +QSP+ + K++ T +
Sbjct: 385 DIECQKLIMEAMKYH-----------LLPERRPMLQSPRTK-----PRKSTVGTLFAVGG 428
Query: 308 LDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMN 367
+D ST + ++++ + + P++ M R G A ++
Sbjct: 429 MD-------------------STKGATSIEKYDLRTN--MWTPVANMNGRRLQFGVAVLD 467
Query: 368 GKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHS 427
KL GG + + L TVECYNP T WS + PM T R +AVL G +Y VGG +G S
Sbjct: 468 DKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 527
Query: 428 DDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDP 487
L+ E +D W V + T R GV L+GKLY VGG D G LK+ + FDP
Sbjct: 528 Y-LNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD--GSSCLKSVECFDP 584
Query: 488 VTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAES------WNCLNTVERYNPENNTWTL 541
T WT CA ++ RR V G LY IGG ++ + VERY+P+ + WT
Sbjct: 585 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 644
Query: 542 IAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGI 601
+A M+++R GV +L KL+ GG+DG ++ VE YDP NEW + + R+ A +
Sbjct: 645 VASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 704
Query: 602 ATV 604
TV
Sbjct: 705 VTV 707
Score = 187 bits (475), Expect = 3e-47
Identities = 102/273 (37%), Positives = 147/273 (53%), Gaps = 9/273 (3%)
Query: 368 GKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHS 427
G L A GG + + ++E Y+ T+ W+ +A M R +F +AVL +LYVVGG +G
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 480
Query: 428 DDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDP 487
L+ E Y+ W +P + T+R GV L G +Y VGG D G L + +DP
Sbjct: 481 T-LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD--GWSYLNTVERWDP 537
Query: 488 VTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNV 547
+ W A ++ R V L G LY +GG + +CL +VE ++P N WTL A M+
Sbjct: 538 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSK 597
Query: 548 ARRGAGVAVLNGKLFVCGGFDG------SHAISCVEMYDPTRNEWKMMGNMTSPRSNAGI 601
R G GV NG L+ GG D S CVE YDP + W + +M+ R G+
Sbjct: 598 RRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGV 657
Query: 602 ATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
+G+ +YAVGG+DG +LNTVE Y+ ++NEW+
Sbjct: 658 CLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 690
Score = 40.0 bits (92), Expect = 0.007
Identities = 18/44 (40%), Positives = 29/44 (65%), Gaps = 1/44 (2%)
Query: 592 MTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSP 635
+ SPR+ +TVG T++AVGG D + ++E Y+L +N W+P
Sbjct: 408 LQSPRTKPRKSTVG-TLFAVGGMDSTKGATSIEKYDLRTNMWTP 450
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 251 bits (642), Expect = 1e-66
Identities = 170/603 (28%), Positives = 283/603 (46%), Gaps = 53/603 (8%)
Query: 9 FEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPH 68
F+ N E + K+ + Q CDV L + AHR VL+ S Y +F +D
Sbjct: 197 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREA 256
Query: 69 GISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSR 128
+K + + P ++ L+ YAYT +L+ ++ ++ + S A L++ +V + C +L+ +
Sbjct: 257 RQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQ 316
Query: 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVC 187
+ ++C+ R+FA G + L Y EH +++ +EF+ LP ++ +L D++
Sbjct: 317 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMN 376
Query: 188 LPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSD 247
+P+ + ++ WV+ + + L +L+ ++ + L D + V D
Sbjct: 377 IPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQF------LADMENNVLFRD 430
Query: 248 DDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAV 307
D Q + + + + L +QSP+ + K++ T +
Sbjct: 431 DIECQKLIMEAMKYH-----------LLPERRPMLQSPRTK-----PRKSTVGTLFAVGG 474
Query: 308 LDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMN 367
+D ST + ++++ + + P++ M R G A ++
Sbjct: 475 MD-------------------STKGATSIEKYDLRTN--MWTPVANMNGRRLQFGVAVLD 513
Query: 368 GKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHS 427
KL GG + + L TVECYNP T WS + PM T R +AVL G +Y VGG +G S
Sbjct: 514 DKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS 573
Query: 428 DDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDP 487
L+ E +D W V + T R GV L+GKLY VGG D G LK+ + FDP
Sbjct: 574 Y-LNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD--GSSCLKSVECFDP 630
Query: 488 VTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAES------WNCLNTVERYNPENNTWTL 541
T WT CA ++ RR V G LY IGG ++ + VERY+P+ + WT
Sbjct: 631 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 690
Query: 542 IAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGI 601
+A M+++R GV +L KL+ GG+DG ++ VE YDP NEW + + R+ A +
Sbjct: 691 VASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 750
Query: 602 ATV 604
TV
Sbjct: 751 VTV 753
Score = 187 bits (475), Expect = 3e-47
Identities = 102/273 (37%), Positives = 147/273 (53%), Gaps = 9/273 (3%)
Query: 368 GKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHS 427
G L A GG + + ++E Y+ T+ W+ +A M R +F +AVL +LYVVGG +G
Sbjct: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 526
Query: 428 DDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDP 487
L+ E Y+ W +P + T+R GV L G +Y VGG D G L + +DP
Sbjct: 527 T-LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD--GWSYLNTVERWDP 583
Query: 488 VTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNV 547
+ W A ++ R V L G LY +GG + +CL +VE ++P N WTL A M+
Sbjct: 584 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSK 643
Query: 548 ARRGAGVAVLNGKLFVCGGFDG------SHAISCVEMYDPTRNEWKMMGNMTSPRSNAGI 601
R G GV NG L+ GG D S CVE YDP + W + +M+ R G+
Sbjct: 644 RRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGV 703
Query: 602 ATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
+G+ +YAVGG+DG +LNTVE Y+ ++NEW+
Sbjct: 704 CLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 736
Score = 40.0 bits (92), Expect = 0.007
Identities = 18/44 (40%), Positives = 29/44 (65%), Gaps = 1/44 (2%)
Query: 592 MTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSP 635
+ SPR+ +TVG T++AVGG D + ++E Y+L +N W+P
Sbjct: 454 LQSPRTKPRKSTVG-TLFAVGGMDSTKGATSIEKYDLRTNMWTP 496
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 251 bits (640), Expect = 2e-66
Identities = 174/586 (29%), Positives = 287/586 (48%), Gaps = 45/586 (7%)
Query: 22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPE 81
+N LR CDV + E+ AHR VLA CSPY +F + V+ +++
Sbjct: 50 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 109
Query: 82 AVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFA 141
+ +L++Y YTA+++ +E V+ + AA L++ VK+ C ++L S++ +C+ R FA
Sbjct: 110 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 169
Query: 142 SCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVIN 200
+ LLNK + Y ++H + EEFL L ++ ++ D + + S K++ VI
Sbjct: 170 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 229
Query: 201 WVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPR 260
WV + + LME V+ LL L +Q V+++
Sbjct: 230 WVNHDKDVRQEFMARLMEHVRL-------PLLPREYL-------------VQRVEEEALV 269
Query: 261 ENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGR 320
+N SS+ L P + ++ S +T T + L L ++ + G+
Sbjct: 270 KN-----SSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKL-----MVVVGGQ 319
Query: 321 NSPQSSPTSTPKLSKSLS-FEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNRE 379
PK +S+ ++ +++ + P + R+G+ M G + A GG+N
Sbjct: 320 ---------APKAIRSVECYDFKEERWHQVAELPSRRCRAGM--VYMAGLVFAVGGFNGS 368
Query: 380 ECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSN 439
+RTV+ Y+P D W+ +A MR R+ AVL G LY VGG +G S LS E Y+
Sbjct: 369 LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDG-STGLSSVEAYNIK 427
Query: 440 IDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLN 499
++W V + T R + GV + G LY VGG D ++ L + ++ T WT A ++
Sbjct: 428 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 487
Query: 500 IRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNG 559
RR + V L LY +GG + +VE Y+P N W +A MN+ RR AGV +NG
Sbjct: 488 TRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG 547
Query: 560 KLFVCGGFDGSHAISCVEMYDPTRNEWKMMGN-MTSPRSNAGIATV 604
L+V GG DGS ++ VE Y+PT ++W ++ + M++ RS AG+ +
Sbjct: 548 LLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVI 593
Score = 193 bits (491), Expect = 4e-49
Identities = 110/283 (38%), Positives = 151/283 (53%), Gaps = 5/283 (1%)
Query: 354 MQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVL 413
M+ R+ L T KL+ G + +R+VECY+ + W +A + + R R M +
Sbjct: 296 MKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYM 355
Query: 414 MGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDP 473
G ++ VGG NG S + + YD D W V +R R G LNG LY VGG D
Sbjct: 356 AGLVFAVGGFNG-SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFD- 413
Query: 474 YGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAE--SWNCLNTVER 531
G GL + + ++ + W AP+N RR V +GG LY +GG + S CL+TVE
Sbjct: 414 -GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVEC 472
Query: 532 YNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGN 591
YN N WT IA M+ R GAGV VLN L+ GG DG VE+YDPT N W+ + +
Sbjct: 473 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVAD 532
Query: 592 MTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
M R NAG+ V +Y VGG DG+ L +VE YN +++W+
Sbjct: 533 MNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 575
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 251 bits (640), Expect = 2e-66
Identities = 174/586 (29%), Positives = 287/586 (48%), Gaps = 45/586 (7%)
Query: 22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPE 81
+N LR CDV + E+ AHR VLA CSPY +F + V+ +++
Sbjct: 46 MNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 105
Query: 82 AVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFA 141
+ +L++Y YTA+++ +E V+ + AA L++ VK+ C ++L S++ +C+ R FA
Sbjct: 106 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 165
Query: 142 SCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVIN 200
+ LLNK + Y ++H + EEFL L ++ ++ D + + S K++ VI
Sbjct: 166 DMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 225
Query: 201 WVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPR 260
WV + + LME V+ LL L +Q V+++
Sbjct: 226 WVNHDKDVRQEFMARLMEHVRL-------PLLPREYL-------------VQRVEEEALV 265
Query: 261 ENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGR 320
+N SS+ L P + ++ S +T T + L L ++ + G+
Sbjct: 266 KN-----SSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKL-----MVVVGGQ 315
Query: 321 NSPQSSPTSTPKLSKSLS-FEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNRE 379
PK +S+ ++ +++ + P + R+G+ M G + A GG+N
Sbjct: 316 ---------APKAIRSVECYDFKEERWHQVAELPSRRCRAGM--VYMAGLVFAVGGFNGS 364
Query: 380 ECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSN 439
+RTV+ Y+P D W+ +A MR R+ AVL G LY VGG +G S LS E Y+
Sbjct: 365 LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDG-STGLSSVEAYNIK 423
Query: 440 IDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLN 499
++W V + T R + GV + G LY VGG D ++ L + ++ T WT A ++
Sbjct: 424 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 483
Query: 500 IRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNG 559
RR + V L LY +GG + +VE Y+P N W +A MN+ RR AGV +NG
Sbjct: 484 TRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG 543
Query: 560 KLFVCGGFDGSHAISCVEMYDPTRNEWKMMGN-MTSPRSNAGIATV 604
L+V GG DGS ++ VE Y+PT ++W ++ + M++ RS AG+ +
Sbjct: 544 LLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVI 589
Score = 193 bits (491), Expect = 4e-49
Identities = 110/283 (38%), Positives = 151/283 (53%), Gaps = 5/283 (1%)
Query: 354 MQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVL 413
M+ R+ L T KL+ G + +R+VECY+ + W +A + + R R M +
Sbjct: 292 MKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYM 351
Query: 414 MGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDP 473
G ++ VGG NG S + + YD D W V +R R G LNG LY VGG D
Sbjct: 352 AGLVFAVGGFNG-SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFD- 409
Query: 474 YGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAE--SWNCLNTVER 531
G GL + + ++ + W AP+N RR V +GG LY +GG + S CL+TVE
Sbjct: 410 -GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVEC 468
Query: 532 YNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGN 591
YN N WT IA M+ R GAGV VLN L+ GG DG VE+YDPT N W+ + +
Sbjct: 469 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVAD 528
Query: 592 MTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
M R NAG+ V +Y VGG DG+ L +VE YN +++W+
Sbjct: 529 MNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 571
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 251 bits (640), Expect = 2e-66
Identities = 173/601 (28%), Positives = 284/601 (47%), Gaps = 57/601 (9%)
Query: 13 NFIESSVAKLNALRKSGQFCDVRLQVCGHEML-AHRAVLACCSPYLFEIFNSDSDPHGIS 71
N E ++ K+ K Q CDV L + GH + AHR VL+ S Y +F +D
Sbjct: 163 NHAEQTLRKMENYLKEKQLCDVLL-IAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
Query: 72 HVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131
V+ + ++P A+ L+ YAYT L+ ++ ++ + +AA L++ +V VC ++L+ ++
Sbjct: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
Query: 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPS 190
++C+ R+F G + LLN Y EH +++ + +EFL LP ++ +L D++ +P
Sbjct: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
Query: 191 NGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDH 250
++ ++ WV + L L+ ++
Sbjct: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIR----------------------------- 372
Query: 251 IQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPK-HEWKIVASEKTSNNTYLCLAVLD 309
+ PP+ + SS TG L +++ K H S S T + +
Sbjct: 373 ---LPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVG 429
Query: 310 GIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGK 369
++ V G T+ K ++++ + + + M R G A ++ K
Sbjct: 430 ALYAV----GGMDAMKGTTTIEK------YDLRTNSWLH--IGTMNGRRLQFGVAVIDNK 477
Query: 370 LIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDD 429
L GG + + L TVEC+NP W+ + PM T R +A L G +Y VGG +G S
Sbjct: 478 LYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSY- 536
Query: 430 LSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVT 489
L+ E +D W V + T R GV ALN KLY +GG D G LK+ + FDP T
Sbjct: 537 LNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD--GSSCLKSMEYFDPHT 594
Query: 490 KLWTSCAPLNIRRHQSAVCELGGYLYIIGGAE---SWNCL---NTVERYNPENNTWTLIA 543
W+ CAP++ RR V G+LY++GG + S +C + VERY+P+ ++W+ +A
Sbjct: 595 NKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA 654
Query: 544 PMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIAT 603
P++V R V L KL+V GG+DG ++ VE YD RNEWK + R+ A +
Sbjct: 655 PLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVV 714
Query: 604 V 604
V
Sbjct: 715 V 715
Score = 182 bits (463), Expect = 6e-46
Identities = 106/305 (34%), Positives = 158/305 (51%), Gaps = 10/305 (3%)
Query: 335 KSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDH 394
+ L E + L+ + S MQ R+ + + G L A GG + + T+E Y+ T+
Sbjct: 397 QKLLMEAMKYHLLPERRSMMQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNS 455
Query: 395 WSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRC 454
W + M R +F +AV+ +LYVVGG +G L+ E ++ W +P + T+R
Sbjct: 456 WLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT-LNTVECFNPVGKIWTVMPPMSTHRH 514
Query: 455 NAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYL 514
GV L G +Y VGG D G L + +DP + W A ++ R V L L
Sbjct: 515 GLGVATLEGPMYAVGGHD--GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKL 572
Query: 515 YIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDG----- 569
Y IGG + +CL ++E ++P N W+L APM+ R G GVA NG L+V GG D
Sbjct: 573 YAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNH 632
Query: 570 -SHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNL 628
S CVE YDP + W + ++ PR + +G+ +Y VGG+DG+ +LNTVE Y+
Sbjct: 633 CSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDA 692
Query: 629 ESNEW 633
+ NEW
Sbjct: 693 QRNEW 697
Score = 137 bits (346), Expect = 2e-32
Identities = 65/172 (37%), Positives = 97/172 (56%), Gaps = 2/172 (1%)
Query: 463 GKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAES 522
G LY VGG D KG + +D T W +N RR Q V + LY++GG +
Sbjct: 429 GALYAVGGMD--AMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDG 486
Query: 523 WNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPT 582
LNTVE +NP WT++ PM+ R G GVA L G ++ GG DG ++ VE +DP
Sbjct: 487 LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPE 546
Query: 583 RNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
+W + +M++PRS G+ + N +YA+GG DG+ L ++E ++ +N+WS
Sbjct: 547 GRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWS 598
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 250 bits (638), Expect = 3e-66
Identities = 170/584 (29%), Positives = 278/584 (47%), Gaps = 57/584 (9%)
Query: 13 NFIESSVAKLNALRKSGQFCDVRLQVCGHEML-AHRAVLACCSPYLFEIFNSDSDPHGIS 71
N E ++ K+ K Q CDV L + GH + AHR VL+ S Y +F +D
Sbjct: 163 NHAEQTLRKMENYLKEKQLCDVLL-IAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
Query: 72 HVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDV 131
V+ + ++P A+ L+ YAYT L+ ++ ++ + +AA L++ +V VC ++L+ ++
Sbjct: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
Query: 132 TSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPS 190
++C+ R+F G + LLN Y EH +++ + +EFL LP ++ +L D++ +P
Sbjct: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
Query: 191 NGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDH 250
++ ++ WV + L L+ ++
Sbjct: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIR----------------------------- 372
Query: 251 IQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPK-HEWKIVASEKTSNNTYLCLAVLD 309
+ PP+ + SS TG L +++ K H S S T + +
Sbjct: 373 ---LPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVG 429
Query: 310 GIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGK 369
++ V G T+ K ++++ + + + M R G A ++ K
Sbjct: 430 ALYAV----GGMDAMKGTTTIEK------YDLRTNSWLH--IGTMNGRRLQFGVAVIDNK 477
Query: 370 LIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDD 429
L GG + + L TVEC+NP W+ + PM T R +A L G +Y VGG +G S
Sbjct: 478 LYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSY- 536
Query: 430 LSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVT 489
L+ E +D W V + T R GV ALN KLY +GG D G LK+ + FDP T
Sbjct: 537 LNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD--GSSCLKSMEYFDPHT 594
Query: 490 KLWTSCAPLNIRRHQSAVCELGGYLYIIGGAE---SWNCL---NTVERYNPENNTWTLIA 543
W+ CAP++ RR V G+LY++GG + S +C + VERY+P+ ++W+ +A
Sbjct: 595 NKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA 654
Query: 544 PMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWK 587
P++V R V L KL+V GG+DG ++ VE YD RNEWK
Sbjct: 655 PLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWK 698
Score = 182 bits (463), Expect = 6e-46
Identities = 106/305 (34%), Positives = 158/305 (51%), Gaps = 10/305 (3%)
Query: 335 KSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDH 394
+ L E + L+ + S MQ R+ + + G L A GG + + T+E Y+ T+
Sbjct: 397 QKLLMEAMKYHLLPERRSMMQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNS 455
Query: 395 WSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRC 454
W + M R +F +AV+ +LYVVGG +G L+ E ++ W +P + T+R
Sbjct: 456 WLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKT-LNTVECFNPVGKIWTVMPPMSTHRH 514
Query: 455 NAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYL 514
GV L G +Y VGG D G L + +DP + W A ++ R V L L
Sbjct: 515 GLGVATLEGPMYAVGGHD--GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKL 572
Query: 515 YIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDG----- 569
Y IGG + +CL ++E ++P N W+L APM+ R G GVA NG L+V GG D
Sbjct: 573 YAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNH 632
Query: 570 -SHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNL 628
S CVE YDP + W + ++ PR + +G+ +Y VGG+DG+ +LNTVE Y+
Sbjct: 633 CSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDA 692
Query: 629 ESNEW 633
+ NEW
Sbjct: 693 QRNEW 697
Score = 137 bits (346), Expect = 2e-32
Identities = 65/172 (37%), Positives = 97/172 (56%), Gaps = 2/172 (1%)
Query: 463 GKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAES 522
G LY VGG D KG + +D T W +N RR Q V + LY++GG +
Sbjct: 429 GALYAVGGMD--AMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDG 486
Query: 523 WNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPT 582
LNTVE +NP WT++ PM+ R G GVA L G ++ GG DG ++ VE +DP
Sbjct: 487 LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPE 546
Query: 583 RNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
+W + +M++PRS G+ + N +YA+GG DG+ L ++E ++ +N+WS
Sbjct: 547 GRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWS 598
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 249 bits (637), Expect = 4e-66
Identities = 171/590 (28%), Positives = 291/590 (49%), Gaps = 45/590 (7%)
Query: 22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPE 81
+N LR CDV + E+ AHR VLA CSPY +F D ++ D++ +
Sbjct: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 99
Query: 82 AVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFA 141
+ L++Y YTA+++ +E V+ + AA L++ V+Q C D+L S++ T+C+ R FA
Sbjct: 100 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFA 159
Query: 142 SCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYTKVIN 200
+ LL + +AY ++H ++ EEFL L ++ ++ D + + S K++ VI+
Sbjct: 160 DVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVIS 219
Query: 201 WVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPR 260
W+ + + +LME V+ D+ +Q V+++
Sbjct: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYL--------------------VQTVEEEALI 259
Query: 261 ENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGR 320
+N +++ L P + ++ + +T T + L + +I + G+
Sbjct: 260 KN-----NNTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKV-----MIVVGGQ 309
Query: 321 NSPQSSPTSTPKLSKSLS-FEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNRE 379
PK +S+ ++ ++D + P + R+G+ M G + A GG+N
Sbjct: 310 ---------APKAIRSVECYDFEEDRWDQIAELPSRRCRAGV--VFMAGHVYAVGGFNGS 358
Query: 380 ECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSN 439
+RTV+ Y+ D W+ +A M+ R+ AVL LY VGG +G S L+ E Y
Sbjct: 359 LRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDG-STGLASVEAYSYK 417
Query: 440 IDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLN 499
++W V + T R + GV + GKLY VGG D ++ L + ++P T W A ++
Sbjct: 418 TNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMS 477
Query: 500 IRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNG 559
RR + V L G LY GG + +VE Y+P NTW +A MN+ RR AGV +NG
Sbjct: 478 TRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNG 537
Query: 560 KLFVCGGFDGSHAISCVEMYDPTRNEWKMM-GNMTSPRSNAGIATVGNTI 608
L+V GG DGS ++ VE Y+P ++W ++ NM++ RS AG+A + ++
Sbjct: 538 LLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
Score = 188 bits (478), Expect = 1e-47
Identities = 103/267 (38%), Positives = 145/267 (54%), Gaps = 6/267 (2%)
Query: 370 LIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDD 429
+I GG + +R+VECY+ D W +A + + R R + + G +Y VGG NG S
Sbjct: 303 MIVVGG-QAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNG-SLR 360
Query: 430 LSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVT 489
+ ++YD D W + ++ R G LN LY VGG D G GL + + + T
Sbjct: 361 VRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFD--GSTGLASVEAYSYKT 418
Query: 490 KLWTSCAPLNIRRHQSAVCELGGYLYIIGGAE--SWNCLNTVERYNPENNTWTLIAPMNV 547
W AP+N RR V + G LY +GG + S CL+TVE+YNP N W +A M+
Sbjct: 419 NEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMST 478
Query: 548 ARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNT 607
R GAGV VL+G+L+ GG DG VE+YDP N WK + +M R NAG+ V
Sbjct: 479 RRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGL 538
Query: 608 IYAVGGFDGNEFLNTVEVYNLESNEWS 634
+Y VGG DG+ L +VE YN +++W+
Sbjct: 539 LYVVGGDDGSCNLASVEYYNPVTDKWT 565
Score = 53.9 bits (128), Expect = 4e-07
Identities = 25/75 (33%), Positives = 41/75 (54%)
Query: 560 KLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEF 619
K+ + G AI VE YD + W + + S R AG+ + +YAVGGF+G+
Sbjct: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR 360
Query: 620 LNTVEVYNLESNEWS 634
+ TV+VY+ ++W+
Sbjct: 361 VRTVDVYDGVKDQWT 375
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 236 bits (601), Expect = 6e-62
Identities = 159/565 (28%), Positives = 267/565 (47%), Gaps = 53/565 (9%)
Query: 47 RAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVY 106
R VL+ S Y +F +D +K + + P ++ L+ YAYT +L+ ++ ++ +
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 107 SAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISE 166
S A L++ +V + C +L+ ++ ++C+ R+FA G + L Y EH +++
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 167 EEEFLKLPRLKLEVML-EDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYY 225
+EF+ LP ++ +L D++ +P+ + ++ WV+ + + L +L+ ++
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 226 SADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSP 285
+ L D + V DD Q + + + + L +QSP
Sbjct: 354 APQF------LADMENNVLFRDDIECQKLIMEAMKYH-----------LLPERRPMLQSP 396
Query: 286 KHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDE 345
+ + K++ T + +D ST + ++++ +
Sbjct: 397 RTK-----PRKSTVGTLFAVGGMD-------------------STKGATSIEKYDLRTN- 431
Query: 346 LIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPR 405
+ P++ M R G A ++ KL GG + + L TVECYNP T WS + PM T R
Sbjct: 432 -MWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHR 490
Query: 406 ARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKL 465
+AVL G +Y VGG +G S L+ E +D W V + T R GV L+GKL
Sbjct: 491 HGLGVAVLEGPMYAVGGHDGWSY-LNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKL 549
Query: 466 YIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAES--- 522
Y VGG D G LK+ + FDP T WT CA ++ RR V G LY IGG ++
Sbjct: 550 YAVGGRD--GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 607
Query: 523 ---WNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMY 579
+ VERY+P+ + WT +A M+++R GV +L KL+ GG+DG ++ VE Y
Sbjct: 608 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 667
Query: 580 DPTRNEWKMMGNMTSPRSNAGIATV 604
DP NEW + + R+ A + TV
Sbjct: 668 DPQTNEWTQVAPLCLGRAGACVVTV 692
Score = 187 bits (475), Expect = 3e-47
Identities = 102/273 (37%), Positives = 147/273 (53%), Gaps = 9/273 (3%)
Query: 368 GKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHS 427
G L A GG + + ++E Y+ T+ W+ +A M R +F +AVL +LYVVGG +G
Sbjct: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLK 465
Query: 428 DDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDP 487
L+ E Y+ W +P + T+R GV L G +Y VGG D G L + +DP
Sbjct: 466 T-LNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHD--GWSYLNTVERWDP 522
Query: 488 VTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNV 547
+ W A ++ R V L G LY +GG + +CL +VE ++P N WTL A M+
Sbjct: 523 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSK 582
Query: 548 ARRGAGVAVLNGKLFVCGGFDG------SHAISCVEMYDPTRNEWKMMGNMTSPRSNAGI 601
R G GV NG L+ GG D S CVE YDP + W + +M+ R G+
Sbjct: 583 RRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGV 642
Query: 602 ATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
+G+ +YAVGG+DG +LNTVE Y+ ++NEW+
Sbjct: 643 CLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWT 675
Score = 40.0 bits (92), Expect = 0.007
Identities = 18/44 (40%), Positives = 29/44 (65%), Gaps = 1/44 (2%)
Query: 592 MTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSP 635
+ SPR+ +TVG T++AVGG D + ++E Y+L +N W+P
Sbjct: 393 LQSPRTKPRKSTVG-TLFAVGGMDSTKGATSIEKYDLRTNMWTP 435
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 218 bits (555), Expect = 1e-56
Identities = 156/580 (26%), Positives = 265/580 (45%), Gaps = 48/580 (8%)
Query: 27 KSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVL 86
++G+ CDV L+V + H+ VLAC PY +F S+ + ++ D + +A+E L
Sbjct: 62 ENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDL 121
Query: 87 LNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGD 146
+ + Y+++L + V+ + AA L+++ V + C +Y+ ++C++ R FA
Sbjct: 122 VKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNR 181
Query: 147 SRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGK-LYTKVINWVQRS 205
L++ D Y +H ++ E E+F+ + L +L + N K +Y I W+ +
Sbjct: 182 IDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLAN 241
Query: 206 IWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHK 265
+ L+E + +V+ LL + L G +++ N H
Sbjct: 242 PQHHSKWLDETLAQVRL-------PLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHL 294
Query: 266 QISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQS 325
+SS + P E+ I + + L FCV G P
Sbjct: 295 HLSSRAV------------PDFEYSIRTTPRKHTAGVL--------FCVGGRGGSGDPFR 334
Query: 326 SPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTV 385
S S F + M R +G + GK+ A GG++ E L ++
Sbjct: 335 SIECYSINKNSWFFGPE-----------MNSRRRHVGVISVEGKVYAVGGHDGNEHLGSM 383
Query: 386 ECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCG---EMYDSNIDD 442
E ++P T+ W A M T R +A L G +Y +GG DD +C E YD D
Sbjct: 384 EMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGL----DDNTCFNDVERYDIESDQ 439
Query: 443 WIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRR 502
W V + T R G AL +Y VGG+D G L + + +DP W + RR
Sbjct: 440 WSTVAPMNTPRGGVGSVALVNHVYAVGGND--GMASLSSVERYDPHLDKWIEVKEMGQRR 497
Query: 503 HQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLF 562
+ V +L G LY++GG + + L++VERY+P +N W +A + R G G+A + GK+F
Sbjct: 498 AGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIF 557
Query: 563 VCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIA 602
GG +G+ ++ VE +DP N W+++G+++ R+ AG+A
Sbjct: 558 AVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVA 597
Score = 170 bits (430), Expect = 4e-42
Identities = 95/266 (35%), Positives = 132/266 (49%), Gaps = 49/266 (18%)
Query: 415 GQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPY 474
G L+ VGG G D E Y N + W PE+ + R + GV ++ GK+Y VGG D
Sbjct: 318 GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHD-- 375
Query: 475 GQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNP 534
G + L + ++FDP+T W A +N +R A+ LGG +Y IGG + C N VERY+
Sbjct: 376 GNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDI 435
Query: 535 ENNTWTLIAPMNVARRGAG----------------------------------------- 553
E++ W+ +APMN R G G
Sbjct: 436 ESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQ 495
Query: 554 ------VAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNT 607
V+ L+G L+V GGFD + +S VE YDP N+W + +T+PR GIATV
Sbjct: 496 RRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGK 555
Query: 608 IYAVGGFDGNEFLNTVEVYNLESNEW 633
I+AVGG +GN +LNTVE ++ N W
Sbjct: 556 IFAVGGHNGNAYLNTVEAFDPVLNRW 581
Score = 100 bits (248), Expect = 5e-21
Identities = 47/124 (37%), Positives = 72/124 (58%), Gaps = 1/124 (0%)
Query: 512 GYLYIIGG-AESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGS 570
G L+ +GG S + ++E Y+ N+W MN RR GV + GK++ GG DG+
Sbjct: 318 GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGN 377
Query: 571 HAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLES 630
+ +EM+DP N+W M +M + R +A++G IYA+GG D N N VE Y++ES
Sbjct: 378 EHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIES 437
Query: 631 NEWS 634
++WS
Sbjct: 438 DQWS 441
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 218 bits (554), Expect = 2e-56
Identities = 156/535 (29%), Positives = 264/535 (49%), Gaps = 45/535 (8%)
Query: 73 VKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVT 132
V+ +++ + +L++Y YTA+++ +E V+ + AA L++ VK+ C ++L S++
Sbjct: 9 VRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPV 68
Query: 133 SCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSN 191
+C+ R FA + LLNK + Y ++H + EEFL L ++ ++ D + + S
Sbjct: 69 NCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSE 128
Query: 192 GKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHI 251
K++ VI WV + + LME V+ LL L +
Sbjct: 129 EKVFEAVIAWVNHDKDVRQEFMARLMEHVRL-------PLLPREYL-------------V 168
Query: 252 QFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGI 311
Q V+++ +N SS+ L P + ++ S +T T + L L
Sbjct: 169 QRVEEEALVKN-----SSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKL--- 220
Query: 312 FCVIFLHGRNSPQSSPTSTPKLSKSLS-FEMQQDELIEKPMSPMQYARSGLGTAEMNGKL 370
++ + G+ PK +S+ ++ +++ + P + R+G+ M G +
Sbjct: 221 --MVVVGGQ---------APKAIRSVECYDFKEERWHQVAELPSRRCRAGM--VYMAGLV 267
Query: 371 IAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDL 430
A GG+N +RTV+ Y+P D W+ +A MR R+ AVL G LY VGG +G S L
Sbjct: 268 FAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDG-STGL 326
Query: 431 SCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTK 490
S E Y+ ++W V + T R + GV + G LY VGG D ++ L + ++ T
Sbjct: 327 SSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTN 386
Query: 491 LWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARR 550
WT A ++ RR + V L LY +GG + +VE Y+P N W +A MN+ RR
Sbjct: 387 EWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRR 446
Query: 551 GAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGN-MTSPRSNAGIATV 604
AGV +NG L+V GG DGS ++ VE Y+PT ++W ++ + M++ RS AG+ +
Sbjct: 447 NAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVI 501
Score = 193 bits (491), Expect = 4e-49
Identities = 110/283 (38%), Positives = 151/283 (53%), Gaps = 5/283 (1%)
Query: 354 MQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVL 413
M+ R+ L T KL+ G + +R+VECY+ + W +A + + R R M +
Sbjct: 204 MKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYM 263
Query: 414 MGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDP 473
G ++ VGG NG S + + YD D W V +R R G LNG LY VGG D
Sbjct: 264 AGLVFAVGGFNG-SLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFD- 321
Query: 474 YGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAE--SWNCLNTVER 531
G GL + + ++ + W AP+N RR V +GG LY +GG + S CL+TVE
Sbjct: 322 -GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVEC 380
Query: 532 YNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGN 591
YN N WT IA M+ R GAGV VLN L+ GG DG VE+YDPT N W+ + +
Sbjct: 381 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVAD 440
Query: 592 MTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
M R NAG+ V +Y VGG DG+ L +VE YN +++W+
Sbjct: 441 MNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWT 483
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 209 bits (532), Expect = 6e-54
Identities = 155/564 (27%), Positives = 263/564 (46%), Gaps = 31/564 (5%)
Query: 16 ESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKF 75
+S + +N+LRKS CDV L+V + AHR VLA CS Y +F S+ G +V
Sbjct: 17 KSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDI 76
Query: 76 DDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
L +E+LL++ YT + E V+++ AA L++ VKQ C ++L S++D ++C+
Sbjct: 77 QGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCL 136
Query: 136 SYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLE-DNVCLPSNGKL 194
R+FA L+ + + Q+H ++ + EEF+ L + ++E +++ D + + S +
Sbjct: 137 GIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPV 196
Query: 195 YTKVINWVQRSIWENGDSLEELMEEVQ----TLYYSAD---------HKLLDGNLLDGQA 241
+ VINWV+ + E +SL L++ V+ T Y D L +L+D
Sbjct: 197 FEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAK 256
Query: 242 EVFGSDDDHIQFVQKKPPRENGHKQI--SSSSTGCLSSPNATVQ--SPK-HEWKIVASEK 296
+ + Q + G ++ G SP V+ PK EW + S
Sbjct: 257 KFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSIT 316
Query: 297 TSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQY 356
+++ D I+ + GR+ S + L + +D + ++PM
Sbjct: 317 RKRRYVASVSLHDRIYVIGGYDGRSRLSS--------VECLDYTADEDG-VWYSVAPMNV 367
Query: 357 ARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQ 416
R G + + +GG++ ++E Y+P+ D WS L M+T R + V G
Sbjct: 368 RRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGV 427
Query: 417 LYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQ 476
+Y +GG +G + L+ E YD + W V + T R AGV LN +Y+VGG D G
Sbjct: 428 IYCLGGYDG-LNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD--GT 484
Query: 477 KGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPEN 536
L + + ++ T WT+ + R L G LY I G + + L+++E Y+P
Sbjct: 485 AHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPII 544
Query: 537 NTWTLIAPMNVARRGAGVAVLNGK 560
++W ++ M R AGV VL K
Sbjct: 545 DSWEVVTSMGTQRCDAGVCVLREK 568
Score = 169 bits (427), Expect = 9e-42
Identities = 97/299 (32%), Positives = 148/299 (49%), Gaps = 12/299 (4%)
Query: 345 ELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREEC-LRTVECYNPHTDHWSFLAPMRT 403
EL + P AR G N L+ GG+ ++ + VE Y+P T WSFL +
Sbjct: 263 ELRSQMQGPRTRARLGA-----NEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITR 317
Query: 404 PRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDD---WIPVPELRTNRCNAGVCA 460
R L ++YV+GG +G S LS E D D+ W V + R AG
Sbjct: 318 KRRYVASVSLHDRIYVIGGYDGRS-RLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATT 376
Query: 461 LNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520
L +Y+ GG D G + + + +DP W+ + R + + G +Y +GG
Sbjct: 377 LGDMIYVSGGFD--GSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGY 434
Query: 521 ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYD 580
+ N LN+VE+Y+P WT + PM R GAGVA+LN ++V GGFDG+ +S VE Y+
Sbjct: 435 DGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYN 494
Query: 581 PTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKI 639
+ W + +MT+PR G + +YA+ G+DGN L+++E Y+ + W T +
Sbjct: 495 IRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553
Score = 145 bits (365), Expect = 1e-34
Identities = 78/250 (31%), Positives = 130/250 (52%), Gaps = 6/250 (2%)
Query: 358 RSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDH---WSFLAPMRTPRARFQMAVLM 414
R + + ++ ++ GGY+ L +VEC + D W +APM R L
Sbjct: 319 RRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLG 378
Query: 415 GQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPY 474
+YV GG +G S E YD NID W + +++T R AG+ +G +Y +GG D
Sbjct: 379 DMIYVSGGFDGSRRHTSM-ERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYD-- 435
Query: 475 GQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNP 534
G L + + +DP T WT+ P+ +R + V L ++Y++GG + L++VE YN
Sbjct: 436 GLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNI 495
Query: 535 ENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTS 594
++WT + M R G VL G+L+ G+DG+ +S +E YDP + W+++ +M +
Sbjct: 496 RTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGT 555
Query: 595 PRSNAGIATV 604
R +AG+ +
Sbjct: 556 QRCDAGVCVL 565
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 207 bits (526), Expect = 3e-53
Identities = 156/561 (27%), Positives = 264/561 (47%), Gaps = 25/561 (4%)
Query: 12 ENFIESSVAKLNALRKSGQFCDVRLQVC-----GHEMLAHRAVLACCSPYLFEIFNSDSD 66
E+ + + +N LR S Q CDV LQV + +AH+ VLA SP +F +
Sbjct: 57 EDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLR 116
Query: 67 PHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLL 126
G+ V + ++P+ +E L+ +AYTA + ++ V V + A ++D V + C D+L+
Sbjct: 117 EQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLV 176
Query: 127 SRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLE-DN 185
++D ++ I NFA +G L + YI H +++++EEF L +L ++ D+
Sbjct: 177 QQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDD 236
Query: 186 VCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFG 245
+ + +++ INWV+ + ++ L+ V+ +S L L + E+
Sbjct: 237 LNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRC--HSLTPNFLQMQLQ--KCEILQ 292
Query: 246 SDDDHIQFVQKKPPRENGHK--QISSSSTGCLSSPNATVQSP-KHEWKIVASEKTSNNTY 302
SD ++ K HK Q+ + T + + + S+ T+
Sbjct: 293 SDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTW 352
Query: 303 LCLAVLD----GIF-CVI--FLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQ 355
L LA L G+ CV+ L+ +SP S + ++ P +PM
Sbjct: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQW--SPCAPMS 410
Query: 356 YARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMG 415
R+ +G ++G + A GG + +VE Y P D W +APM T R +AVL
Sbjct: 411 VPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNR 470
Query: 416 QLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYG 475
LY VGG +G ++ L+ E Y ++W + + T R AGVC L+ +Y GG D G
Sbjct: 471 LLYAVGGFDG-TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD--G 527
Query: 476 QKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPE 535
Q L + + +D T+ WT AP+ RR + G +Y++GG + L++VE Y+P+
Sbjct: 528 QDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPD 587
Query: 536 NNTWTLIAPMNVARRGAGVAV 556
+TW+ + M R G GVAV
Sbjct: 588 TDTWSEVTRMTSGRSGVGVAV 608
Score = 174 bits (442), Expect = 2e-43
Identities = 98/258 (37%), Positives = 134/258 (51%), Gaps = 11/258 (4%)
Query: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRT----VECYNPHTDHWSFLAPMRTPRA 406
++ +Q RSGL + G L A GG N T ++CYNP T+ WS APM PR
Sbjct: 355 LADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRN 414
Query: 407 RFQMAVLMGQLYVVGGSNG--HSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGK 464
R + V+ G +Y VGGS+G H + + E Y+ D+W V + T R GV LN
Sbjct: 415 RIGVGVIDGHIYAVGGSHGCIHHNSV---ERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 465 LYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWN 524
LY VGG D G L + + + P W +N R + VC L +Y GG + +
Sbjct: 472 LYAVGGFD--GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
Query: 525 CLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRN 584
LN+VERY+ E TWT +APM R G+ V G+++V GG+DG + VE YDP +
Sbjct: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
Query: 585 EWKMMGNMTSPRSNAGIA 602
W + MTS RS G+A
Sbjct: 590 TWSEVTRMTSGRSGVGVA 607
Score = 173 bits (439), Expect = 4e-43
Identities = 101/276 (36%), Positives = 143/276 (51%), Gaps = 7/276 (2%)
Query: 368 GKLI-AAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGH 426
G+LI AGGY R+ L +E YNP W LA ++ PR+ V+ G LY VGG N
Sbjct: 325 GRLIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNS 383
Query: 427 SD---DLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCD 483
D D S + Y+ + W P + R GV ++G +Y VGGS +G + +
Sbjct: 384 PDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGS--HGCIHHNSVE 441
Query: 484 VFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIA 543
++P W AP+ RR V L LY +GG + N LN+ E Y PE N W +I
Sbjct: 442 RYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMIT 501
Query: 544 PMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIAT 603
MN R GAGV VL+ ++ GG+DG ++ VE YD W + M RS GI
Sbjct: 502 AMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITV 561
Query: 604 VGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKI 639
IY +GG+DG+ FL++VE Y+ +++ WS T++
Sbjct: 562 HQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRM 597
Score = 52.8 bits (125), Expect = 1e-06
Identities = 25/64 (39%), Positives = 38/64 (59%)
Query: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQM 410
++PM++ RS LG G++ GGY+ L +VECY+P TD WS + M + R+ +
Sbjct: 547 VAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
Query: 411 AVLM 414
AV M
Sbjct: 607 AVTM 610
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 207 bits (526), Expect = 3e-53
Identities = 156/561 (27%), Positives = 264/561 (47%), Gaps = 25/561 (4%)
Query: 12 ENFIESSVAKLNALRKSGQFCDVRLQVC-----GHEMLAHRAVLACCSPYLFEIFNSDSD 66
E+ + + +N LR S Q CDV LQV + +AH+ VLA SP +F +
Sbjct: 57 EDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLR 116
Query: 67 PHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLL 126
G+ V + ++P+ +E L+ +AYTA + ++ V V + A ++D V + C D+L+
Sbjct: 117 EQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLV 176
Query: 127 SRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLE-DN 185
++D ++ I NFA +G L + YI H +++++EEF L +L ++ D+
Sbjct: 177 QQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDD 236
Query: 186 VCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFG 245
+ + +++ INWV+ + ++ L+ V+ +S L L + E+
Sbjct: 237 LNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRC--HSLTPNFLQMQLQ--KCEILQ 292
Query: 246 SDDDHIQFVQKKPPRENGHK--QISSSSTGCLSSPNATVQSP-KHEWKIVASEKTSNNTY 302
SD ++ K HK Q+ + T + + + S+ T+
Sbjct: 293 SDSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTW 352
Query: 303 LCLAVLD----GIF-CVI--FLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQ 355
L LA L G+ CV+ L+ +SP S + ++ P +PM
Sbjct: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQW--SPCAPMS 410
Query: 356 YARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMG 415
R+ +G ++G + A GG + +VE Y P D W +APM T R +AVL
Sbjct: 411 VPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNR 470
Query: 416 QLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYG 475
LY VGG +G ++ L+ E Y ++W + + T R AGVC L+ +Y GG D G
Sbjct: 471 LLYAVGGFDG-TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD--G 527
Query: 476 QKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPE 535
Q L + + +D T+ WT AP+ RR + G +Y++GG + L++VE Y+P+
Sbjct: 528 QDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPD 587
Query: 536 NNTWTLIAPMNVARRGAGVAV 556
+TW+ + M R G GVAV
Sbjct: 588 TDTWSEVTRMTSGRSGVGVAV 608
Score = 174 bits (442), Expect = 2e-43
Identities = 98/258 (37%), Positives = 134/258 (51%), Gaps = 11/258 (4%)
Query: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRT----VECYNPHTDHWSFLAPMRTPRA 406
++ +Q RSGL + G L A GG N T ++CYNP T+ WS APM PR
Sbjct: 355 LADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRN 414
Query: 407 RFQMAVLMGQLYVVGGSNG--HSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGK 464
R + V+ G +Y VGGS+G H + + E Y+ D+W V + T R GV LN
Sbjct: 415 RIGVGVIDGHIYAVGGSHGCIHHNSV---ERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
Query: 465 LYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWN 524
LY VGG D G L + + + P W +N R + VC L +Y GG + +
Sbjct: 472 LYAVGGFD--GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
Query: 525 CLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRN 584
LN+VERY+ E TWT +APM R G+ V G+++V GG+DG + VE YDP +
Sbjct: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
Query: 585 EWKMMGNMTSPRSNAGIA 602
W + MTS RS G+A
Sbjct: 590 TWSEVTRMTSGRSGVGVA 607
Score = 173 bits (439), Expect = 4e-43
Identities = 101/276 (36%), Positives = 143/276 (51%), Gaps = 7/276 (2%)
Query: 368 GKLI-AAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGH 426
G+LI AGGY R+ L +E YNP W LA ++ PR+ V+ G LY VGG N
Sbjct: 325 GRLIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNS 383
Query: 427 SD---DLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCD 483
D D S + Y+ + W P + R GV ++G +Y VGGS +G + +
Sbjct: 384 PDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGS--HGCIHHNSVE 441
Query: 484 VFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIA 543
++P W AP+ RR V L LY +GG + N LN+ E Y PE N W +I
Sbjct: 442 RYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMIT 501
Query: 544 PMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIAT 603
MN R GAGV VL+ ++ GG+DG ++ VE YD W + M RS GI
Sbjct: 502 AMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITV 561
Query: 604 VGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKI 639
IY +GG+DG+ FL++VE Y+ +++ WS T++
Sbjct: 562 HQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRM 597
Score = 52.8 bits (125), Expect = 1e-06
Identities = 25/64 (39%), Positives = 38/64 (59%)
Query: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQM 410
++PM++ RS LG G++ GGY+ L +VECY+P TD WS + M + R+ +
Sbjct: 547 VAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
Query: 411 AVLM 414
AV M
Sbjct: 607 AVTM 610
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 204 bits (518), Expect = 3e-52
Identities = 153/607 (25%), Positives = 266/607 (43%), Gaps = 72/607 (11%)
Query: 16 ESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKF 75
E + LN LR+ + CD+ L+V ++ AH+ VLA SPY +F + S V+F
Sbjct: 19 EQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEF 78
Query: 76 DDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCI 135
++ A++ ++ YAYT + ++ V+ + AA L++ V + C +L S++D +CI
Sbjct: 79 QCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCI 138
Query: 136 SYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKL 194
FA G L YI ++ + + EEF +L L E++ D + + + +
Sbjct: 139 GISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETV 198
Query: 195 YTKVINWVQRSIWENGDSLEELMEEVQ---------TLYYSADHKLLDGNLLDGQAEVFG 245
+ + +W++ + E L +L+ V+ T Y A+H + D D +
Sbjct: 199 FYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRD----DRTCKHLL 254
Query: 246 SDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCL 305
++ F+ + H+ LS + P+ K++ + + + CL
Sbjct: 255 NEALKYHFMPE-------HR---------LSHQTVLMTRPRCAPKVLCAVGGKSGLFACL 298
Query: 306 AVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAE 365
++ F Q D I ++P+ R G
Sbjct: 299 DSVEMYF----------------------------PQNDSWIG--LAPLNIPRYEFGICV 328
Query: 366 MNGKLIAAGGYNRE--------ECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQL 417
++ K+ GG + +VEC+NP T+ W+ L M R+ + VL G+L
Sbjct: 329 LDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGEL 388
Query: 418 YVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQK 477
Y +GG +G S L E Y I W PV + T R L+G +Y +GG YG
Sbjct: 389 YALGGYDGQSY-LQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGG---YGPA 444
Query: 478 GLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENN 537
+ + + +DP W A + +R V + G+++++GG + L+++ERY+P N
Sbjct: 445 HMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQN 504
Query: 538 TWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRS 597
WT+ PM R G G AV++ L+V GG GS ++ V+ YDP + W M R
Sbjct: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRC 564
Query: 598 NAGIATV 604
N G+ +
Sbjct: 565 NFGLTAL 571
Score = 167 bits (424), Expect = 2e-41
Identities = 92/263 (34%), Positives = 140/263 (53%), Gaps = 16/263 (6%)
Query: 381 CLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGS----------NGHSDDL 430
CL +VE Y P D W LAP+ PR F + VL ++YV+GG H + +
Sbjct: 297 CLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSV 356
Query: 431 SCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTK 490
C ++ + + W + + +R GV L G+LY +GG D GQ L++ + + P +
Sbjct: 357 EC---WNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYD--GQSYLQSVEKYIPKIR 411
Query: 491 LWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARR 550
W AP+ R A L G +Y IGG + +N+VERY+P ++W ++A M R
Sbjct: 412 KWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAH-MNSVERYDPSKDSWEMVASMADKRI 470
Query: 551 GAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYA 610
GV V+ G +FV GG +G +S +E YDP +N+W + M PR+ G A + N +Y
Sbjct: 471 HFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYV 530
Query: 611 VGGFDGNEFLNTVEVYNLESNEW 633
VGG G+ +LNTV+ Y+ S+ W
Sbjct: 531 VGGHSGSSYLNTVQKYDPISDTW 553
Score = 136 bits (342), Expect = 7e-32
Identities = 73/224 (32%), Positives = 118/224 (52%), Gaps = 7/224 (3%)
Query: 417 LYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQ 476
L VGG +G L EMY D WI + L R G+C L+ K+Y++GG +
Sbjct: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
Query: 477 KGL------KNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVE 530
G+ + + ++P T WTS +N R V L G LY +GG + + L +VE
Sbjct: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404
Query: 531 RYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMG 590
+Y P+ W +APM R AVL+G ++ GG+ +H ++ VE YDP+++ W+M+
Sbjct: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAH-MNSVERYDPSKDSWEMVA 463
Query: 591 NMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
+M R + G+ + I+ VGG +G L+++E Y+ N+W+
Sbjct: 464 SMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWT 507
Score = 86.7 bits (213), Expect = 6e-17
Identities = 45/132 (34%), Positives = 72/132 (54%), Gaps = 11/132 (8%)
Query: 514 LYIIGGAES-WNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGS-- 570
L +GG + CL++VE Y P+N++W +AP+N+ R G+ VL+ K++V GG +
Sbjct: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
Query: 571 -------HAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTV 623
H S VE ++P N W + M RS G+ + +YA+GG+DG +L +V
Sbjct: 345 PGVTIRKHENS-VECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSV 403
Query: 624 EVYNLESNEWSP 635
E Y + +W P
Sbjct: 404 EKYIPKIRKWQP 415
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 172 bits (435), Expect = 1e-42
Identities = 136/580 (23%), Positives = 253/580 (43%), Gaps = 49/580 (8%)
Query: 23 NALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEA 82
N LR G+ CDV ++V G E AH+ +L CS Y +F S + ++P+
Sbjct: 30 NELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDM 89
Query: 83 VEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFAS 142
+++++ YAYT + + V+ + +AA + + + + C ++L S + + +CI F
Sbjct: 90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTD 149
Query: 143 CMGDSRLLNKVDAYIQEHLLQ-ISEEEEFLKLPRLKLEVMLE-DNVCLPSNGKLYTKVIN 200
L K +I + + + EFL+L +L+ ++E D + + ++ ++
Sbjct: 150 YYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILK 209
Query: 201 WVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQKKPPR 260
W+ + L+ +V+ A++ + + + D + D + + V +
Sbjct: 210 WISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMND-----YVKDSEECKPVIINALK 264
Query: 261 ENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGR 320
++ S ++P + P + ++F G
Sbjct: 265 AMYDLNMNGPSNSDFTNPLTRPRLP--------------------------YAILFAIGG 298
Query: 321 NSPQSSPTSTPKLSKSLSFEMQQDELIE---KPMSPMQYARSGLGTAEMNGKLIAAGGYN 377
S SPT+ + +++ + D + + SP Y G A + G + GG++
Sbjct: 299 WSG-GSPTNAIE-----AYDARADRWVNVTCEEESPRAYH----GAAYLKGYVYIIGGFD 348
Query: 378 REECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYD 437
+ +V+ ++P W +APM + R + VL +Y +GG +G+ L+ E Y+
Sbjct: 349 SVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVR-LNTAERYE 407
Query: 438 SNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAP 497
+ W + + R +A L GK+YI GG + G + L +V++ + WT AP
Sbjct: 408 PETNQWTLIAPMHEQRSDASATTLYGKVYICGGFN--GNECLFTAEVYNTESNQWTVIAP 465
Query: 498 LNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVL 557
+ RR V G ++Y +GG + N L + E Y+P NTW I M R G+ V+
Sbjct: 466 MRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVV 525
Query: 558 NGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRS 597
+ LFV GGF+G VE YD +EW +M+ RS
Sbjct: 526 DDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRS 565
Score = 167 bits (423), Expect = 3e-41
Identities = 91/245 (37%), Positives = 130/245 (53%), Gaps = 10/245 (4%)
Query: 397 FLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVP-ELRTNRCN 455
F P+ PR + + L+ +GG +G S + E YD+ D W+ V E + R
Sbjct: 279 FTNPLTRPRLPYAI------LFAIGGWSGGSPTNAI-EAYDARADRWVNVTCEEESPRAY 331
Query: 456 AGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLY 515
G L G +YI+GG D + FDPV K W AP++ RR +V LG ++Y
Sbjct: 332 HGAAYLKGYVYIIGGFDSVDY--FNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIY 389
Query: 516 IIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISC 575
+GG + + LNT ERY PE N WTLIAPM+ R A L GK+++CGGF+G+ +
Sbjct: 390 AMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFT 449
Query: 576 VEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSP 635
E+Y+ N+W ++ M S RS G+ G +YAVGGFDG L + E Y+ +N W
Sbjct: 450 AEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRT 509
Query: 636 YTKIF 640
+F
Sbjct: 510 IPTMF 514
Score = 166 bits (420), Expect = 6e-41
Identities = 90/265 (33%), Positives = 135/265 (50%), Gaps = 4/265 (1%)
Query: 370 LIAAGGYNREECLRTVECYNPHTDHW-SFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSD 428
L A GG++ +E Y+ D W + +PRA A L G +Y++GG + D
Sbjct: 293 LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDS-VD 351
Query: 429 DLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPV 488
+ + +D W V + + RC V L +Y +GG D Y + L + ++P
Sbjct: 352 YFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVR--LNTAERYEPE 409
Query: 489 TKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVA 548
T WT AP++ +R ++ L G +YI GG CL T E YN E+N WT+IAPM
Sbjct: 410 TNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSR 469
Query: 549 RRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTI 608
R G GV ++ GGFDG++ + E Y P N W+ + M +PRSN GI V + +
Sbjct: 470 RSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLL 529
Query: 609 YAVGGFDGNEFLNTVEVYNLESNEW 633
+ VGGF+G VE Y+ +++EW
Sbjct: 530 FVVGGFNGFTTTFNVECYDEKTDEW 554
Score = 84.7 bits (208), Expect = 2e-16
Identities = 48/162 (29%), Positives = 79/162 (48%), Gaps = 3/162 (1%)
Query: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQM 410
++PM RS + GK+ GG+N ECL T E YN ++ W+ +APMR+ R+ +
Sbjct: 416 IAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGV 475
Query: 411 AVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGG 470
+Y VGG +G ++ L E Y + W +P + R N G+ ++ L++VGG
Sbjct: 476 IAYGEHVYAVGGFDG-ANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG 534
Query: 471 SDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGG 512
+ G N + +D T W ++I R + C + G
Sbjct: 535 FN--GFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPG 574
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 165 bits (418), Expect = 1e-40
Identities = 92/268 (34%), Positives = 138/268 (51%), Gaps = 4/268 (1%)
Query: 368 GKLIAAGGYNRE-ECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGH 426
G + A GG N + L VE ++P + W PM T R+R +AV+ G LY +GG +G
Sbjct: 288 GLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQ 347
Query: 427 SDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFD 486
LS E Y+ D W V + + R G L+G++Y+ GG D G L + + +
Sbjct: 348 LR-LSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYD--GNSSLSSVETYS 404
Query: 487 PVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMN 546
P T WT ++ R + V G +Y+ GG + ++VE YN TW A M
Sbjct: 405 PETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGML 464
Query: 547 VARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGN 606
R G A L K+FVCGG+DGS +S EMY ++W ++ M + RS +
Sbjct: 465 NKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCG 524
Query: 607 TIYAVGGFDGNEFLNTVEVYNLESNEWS 634
+YAVGG+DG L++VE+Y+ E++ W+
Sbjct: 525 RLYAVGGYDGQSNLSSVEMYDPETDCWT 552
Score = 160 bits (405), Expect = 3e-39
Identities = 88/252 (34%), Positives = 128/252 (50%), Gaps = 3/252 (1%)
Query: 353 PMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAV 412
PM ARS +G A +NG L A GGY+ + L TVE YNP TD W+ + M + R+ V
Sbjct: 321 PMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVV 380
Query: 413 LMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSD 472
L GQ+YV GG +G+S LS E Y D W V + +NR AGV G++Y+ GG D
Sbjct: 381 LDGQIYVCGGYDGNS-SLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHD 439
Query: 473 PYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERY 532
G + + + ++ T W A + +R + LG +++ GG + L+ E Y
Sbjct: 440 --GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMY 497
Query: 533 NPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNM 592
+ + W LI PM+ R + G+L+ GG+DG +S VEMYDP + W M M
Sbjct: 498 SSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPM 557
Query: 593 TSPRSNAGIATV 604
G+ +
Sbjct: 558 ACHEGGVGVGCI 569
Score = 151 bits (382), Expect = 2e-36
Identities = 75/221 (33%), Positives = 118/221 (53%), Gaps = 2/221 (0%)
Query: 413 LMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSD 472
+ G +Y VGG N D L+ E++D + W + T R GV +NG LY +GG D
Sbjct: 286 IAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYD 345
Query: 473 PYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERY 532
GQ L + ++P T WT +N +R L G +Y+ GG + + L++VE Y
Sbjct: 346 --GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETY 403
Query: 533 NPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNM 592
+PE + WT++ M+ R AGV V G+++V GG DG S VE Y+ W M
Sbjct: 404 SPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGM 463
Query: 593 TSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEW 633
+ R G A++G+ ++ GG+DG+ FL+ E+Y+ +++W
Sbjct: 464 LNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQW 504
Score = 148 bits (373), Expect = 2e-35
Identities = 75/191 (39%), Positives = 107/191 (56%), Gaps = 5/191 (2%)
Query: 446 VPELRTN-RCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQ 504
+P RT RC + L +Y VGG + G L +VFDP+ W C P+ R +
Sbjct: 273 LPAFRTRPRCCTSIAGL---IYAVGGLNSAGDS-LNVVEVFDPIANCWERCRPMTTARSR 328
Query: 505 SAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVC 564
V + G LY IGG + L+TVE YNPE +TWT + MN R G VL+G+++VC
Sbjct: 329 VGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVC 388
Query: 565 GGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVE 624
GG+DG+ ++S VE Y P ++W ++ +M+S RS AG+ IY GG DG + ++VE
Sbjct: 389 GGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVE 448
Query: 625 VYNLESNEWSP 635
YN + W P
Sbjct: 449 HYNHHTATWHP 459
Score = 114 bits (284), Expect = 4e-25
Identities = 63/221 (28%), Positives = 115/221 (52%), Gaps = 9/221 (4%)
Query: 10 EDENFIESSVAKLNA--------LRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIF 61
E E+ + SV++L + +R+ G+ CDV L++ H+ AHR VLA PY +F
Sbjct: 8 ELEDLVHFSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMF 67
Query: 62 NSDSDPHGISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVC 121
+D + ++P A+E L+N+AY L D++ V+ + A L++ +K C
Sbjct: 68 TNDMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDAC 127
Query: 122 GDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLP-RLKLEV 180
+L R+ +C+ R FA M + L + +++I +H +++S EEFL LP LE+
Sbjct: 128 CTFLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLEL 187
Query: 181 MLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQ 221
+ D + + S +++ + WV+ + G L EL+ ++
Sbjct: 188 VSRDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIR 228
Score = 109 bits (273), Expect = 7e-24
Identities = 53/131 (40%), Positives = 77/131 (58%), Gaps = 1/131 (0%)
Query: 510 LGGYLYIIGGAES-WNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFD 568
+ G +Y +GG S + LN VE ++P N W PM AR GVAV+NG L+ GG+D
Sbjct: 286 IAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYD 345
Query: 569 GSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNL 628
G +S VE Y+P + W +G+M S RS G + IY GG+DGN L++VE Y+
Sbjct: 346 GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSP 405
Query: 629 ESNEWSPYTKI 639
E+++W+ T +
Sbjct: 406 ETDKWTVVTSM 416
Score = 92.8 bits (229), Expect = 9e-19
Identities = 68/211 (32%), Positives = 96/211 (45%), Gaps = 17/211 (8%)
Query: 289 WKIVASEKTSNNTYLCLAVLDG-IFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELI 347
W V S S + + VLDG I+ G +S S T +P+ K
Sbjct: 363 WTRVGS-MNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTV--------- 412
Query: 348 EKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRAR 407
++ M RS G G++ +GG++ + +VE YN HT W A M R R
Sbjct: 413 ---VTSMSSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCR 469
Query: 408 FQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYI 467
A L +++V GG +G S LS EMY S D W + + T R + A G+LY
Sbjct: 470 HGAASLGSKMFVCGGYDG-SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYA 528
Query: 468 VGGSDPYGQKGLKNCDVFDPVTKLWTSCAPL 498
VGG D GQ L + +++DP T WT AP+
Sbjct: 529 VGGYD--GQSNLSSVEMYDPETDCWTFMAPM 557
Score = 67.0 bits (162), Expect = 5e-11
Identities = 37/109 (33%), Positives = 51/109 (46%), Gaps = 1/109 (0%)
Query: 350 PMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQ 409
P + M R G A + K+ GGY+ L E Y+ D W + PM T R+R
Sbjct: 459 PAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVS 518
Query: 410 MAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGV 458
+ G+LY VGG +G S +LS EMYD D W + + + GV
Sbjct: 519 LVASCGRLYAVGGYDGQS-NLSSVEMYDPETDCWTFMAPMACHEGGVGV 566
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 154 bits (388), Expect = 3e-37
Identities = 137/598 (22%), Positives = 254/598 (42%), Gaps = 77/598 (12%)
Query: 11 DENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGI 70
D ++ + + L+ +R+ CD+ + H++V+A CS Y + I D I
Sbjct: 52 DASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKKDPS---I 108
Query: 71 SHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMD 130
V +D++P + ++ YAYT +L + + SAA L++ + ++C D+L+ M
Sbjct: 109 QRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMS 168
Query: 131 VTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLP 189
V +C+ N A +I+++ L+ +E ++F+KL ++ E++++D++ LP
Sbjct: 169 VENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLIDDDLQLP 228
Query: 190 SNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDD 249
S + + W++ + + + Y+AD L N+ G S D
Sbjct: 229 SEIVAFQIAMKWLEF--------------DQKRVKYAAD---LLSNIRFGTI----SAQD 267
Query: 250 HIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLD 309
+ +VQ P + + + L + + S +T +
Sbjct: 268 LVNYVQSVP------RMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTR--------IRG 313
Query: 310 GIFCVIFLHGRNSPQSSPTSTPK-LSKSLSFEMQQD---ELIEKPMSPMQYARSGLGTAE 365
G ++ + GR P T K LS+ + + ++ +L E P A
Sbjct: 314 GCRVLVTVGGR------PGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQC-----VAV 362
Query: 366 MNGKLIAAGGYNREECLRTVE------C-YNPHTDHWSFLAPMRTPRARFQMAVLMGQLY 418
M+G L AGG ++ + + C Y+P + W LA M R F ++V G +Y
Sbjct: 363 MDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVY 422
Query: 419 VVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGG--SDPYGQ 476
GG N L+ E Y + + W P L RC +G++ + GG ++ Y
Sbjct: 423 AAGGRNAEGS-LASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYS- 480
Query: 477 KGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA------ESWNCLNTVE 530
++ +DP + W L+ R L +Y++GG+ E + L TVE
Sbjct: 481 ---RSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVL-TVE 536
Query: 531 RYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHA--ISCVEMYDPTRNEW 586
Y+P W+ AP+ V AGV+ L+G+ ++ GG++ C++ + P NEW
Sbjct: 537 CYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEW 594
Score = 95.9 bits (237), Expect = 1e-19
Identities = 64/229 (27%), Positives = 104/229 (45%), Gaps = 11/229 (4%)
Query: 417 LYVVGGSNGHSD-DLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDP-- 473
L VGG G ++ LS +Y + W + E+ N V ++G LY+ GG D
Sbjct: 318 LVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQND 377
Query: 474 ---YGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVE 530
+ + N +DP W A +N +R ++ G +Y GG + L ++E
Sbjct: 378 ARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLE 437
Query: 531 RYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMG 590
Y P N W P+ VAR AV +G++ V GG+ + V YDP + W+ +
Sbjct: 438 CYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELP 497
Query: 591 NMTSPRSNAGIATVGNTIYAVGGFD----GNEF-LNTVEVYNLESNEWS 634
N+++PR T+ + +Y +GG G + TVE Y+ + +WS
Sbjct: 498 NLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWS 546
Score = 87.4 bits (215), Expect = 4e-17
Identities = 73/284 (25%), Positives = 118/284 (41%), Gaps = 25/284 (8%)
Query: 370 LIAAGGYN--REECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNG-- 425
L+ GG E+ L Y + WS L M +AV+ G LYV GG +
Sbjct: 318 LVTVGGRPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQND 377
Query: 426 ------HSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGL 479
H+ C YD + WI + + R + + NG +Y GG + G
Sbjct: 378 ARNQAKHAVSNFC--RYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLAS 435
Query: 480 KNCDVFDPVTKLWTSCAPLNIRR--HQSAVCELGGYLYIIGGAESWNCLNTVERYNPENN 537
C V P T W PL + R H SAV + G + + GG + +V Y+P ++
Sbjct: 436 LECYV--PSTNQWQPKTPLEVARCCHASAVAD--GRVLVTGGYIANAYSRSVCAYDPASD 491
Query: 538 TWTLIAPMNVARRGAGVAVLNGKLFVCGGFD----GSHA-ISCVEMYDPTRNEWKMMGNM 592
+W + ++ R L+ +++V GG G + VE Y P +W +
Sbjct: 492 SWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPL 551
Query: 593 TSPRSNAGIATVGNTIYAVGGFDGNE--FLNTVEVYNLESNEWS 634
S AG++ + Y VGG++ E + ++ ++ E NEW+
Sbjct: 552 QVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWT 595
Score = 79.0 bits (193), Expect = 1e-14
Identities = 60/214 (28%), Positives = 94/214 (43%), Gaps = 17/214 (7%)
Query: 285 PKHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQD 344
P+ I + T+ L+V +G+ V GRN+ S + + + ++
Sbjct: 394 PRFNTWIHLASMNQKRTHFSLSVFNGL--VYAAGGRNAEGSLASLECYVPSTNQWQ---- 447
Query: 345 ELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTP 404
P +P++ AR +A +G+++ GGY R+V Y+P +D W L + TP
Sbjct: 448 -----PKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTP 502
Query: 405 RARFQMAVLMGQLYVVGGS----NGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCA 460
R L ++YV+GGS G D+ E Y W L+ AGV A
Sbjct: 503 RGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSA 562
Query: 461 LNGKLYIVGGSDPYGQKGLKNC-DVFDPVTKLWT 493
L+G+ Y+VGG + G+K K C F P WT
Sbjct: 563 LHGRAYLVGGWNE-GEKKYKKCIQCFSPELNEWT 595
Score = 62.4 bits (150), Expect = 1e-09
Identities = 34/115 (29%), Positives = 53/115 (46%), Gaps = 7/115 (6%)
Query: 532 YNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFD-------GSHAISCVEMYDPTRN 584
Y N W+ + M VAV++G L+V GG D HA+S YDP N
Sbjct: 338 YRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFN 397
Query: 585 EWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSPYTKI 639
W + +M R++ ++ +YA GG + L ++E Y +N+W P T +
Sbjct: 398 TWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPL 452
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 152 bits (383), Expect = 1e-36
Identities = 86/261 (32%), Positives = 135/261 (51%), Gaps = 9/261 (3%)
Query: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQM 410
+S + ARSGLG + G + A GG ECY+P T W+ +A M PR +
Sbjct: 326 VSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGV 385
Query: 411 AVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGG 470
V G +Y +GG G ++ + E +D + + W V + +R G C + G +Y++GG
Sbjct: 386 CVCYGAIYALGGWVG-AEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGG 444
Query: 471 SDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGG-AESWNCLNTV 529
G + L++ +V+DP++K W+ P+ RR V L +Y +GG E+ + L+TV
Sbjct: 445 ISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTV 503
Query: 530 ERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSH------AISCVEMYDPTR 583
E+Y+ E W +A M V R G V +NG L+V GG SH + VE+Y+P
Sbjct: 504 EKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHS 563
Query: 584 NEWKMMGNMTSPRSNAGIATV 604
+ W +GNM + R G+A +
Sbjct: 564 DTWTEIGNMITSRCEGGVAVL 584
Score = 127 bits (320), Expect = 2e-29
Identities = 82/281 (29%), Positives = 127/281 (45%), Gaps = 19/281 (6%)
Query: 370 LIAAGGYNR--------EECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVG 421
L A GGY R L VE ++ + +W+ ++ + R+ + VL G +Y +G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 422 GSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKN 481
G S C E YD W V + RC GVC G +Y +GG G +
Sbjct: 350 GEK-DSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGW--VGAEIGNT 406
Query: 482 CDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNC-LNTVERYNPENNTWT 540
+ FDP W + + R+ CE+ G +Y+IGG + L + E Y+P + W+
Sbjct: 407 IERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWS 466
Query: 541 LIAPMNVARRGAGVAVLNGKLFVCGGFDGSH-AISCVEMYDPTRNEWKMMGNMTSPRSNA 599
+ PM R GVA LN ++ GG++ + A+ VE Y +W + +M PR+
Sbjct: 467 PLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGM 526
Query: 600 GIATVGNTIYAVGG------FDGNEFLNTVEVYNLESNEWS 634
+ V +Y GG F L++VEVYN S+ W+
Sbjct: 527 CVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWT 567
Score = 127 bits (318), Expect = 4e-29
Identities = 75/232 (32%), Positives = 116/232 (50%), Gaps = 6/232 (2%)
Query: 405 RARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGK 464
+AR + + G + GG S LSC E +D+ W V L R GV L G
Sbjct: 285 KARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGM 344
Query: 465 LYIVGGSDPYGQKGLKNC-DVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESW 523
+Y +GG + +C + +DPVTK WT+ A +N R VC G +Y +GG
Sbjct: 345 VYAIGGEK---DSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGA 401
Query: 524 NCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSH-AISCVEMYDPT 582
NT+ER++P+ N W ++ M V+R G + G ++V GG + E+YDP
Sbjct: 402 EIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPL 461
Query: 583 RNEWKMMGNMTSPRSNAGIATVGNTIYAVGGF-DGNEFLNTVEVYNLESNEW 633
W + M + R+ G+A + + IY+VGG+ + + L+TVE Y+ E +W
Sbjct: 462 SKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKW 513
Score = 103 bits (256), Expect = 6e-22
Identities = 59/178 (33%), Positives = 86/178 (48%), Gaps = 7/178 (3%)
Query: 465 LYIVGGSDPY------GQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIG 518
LY VGG + L + FD ++ WT+ + L+ R V LGG +Y IG
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 519 GAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEM 578
G + + E Y+P WT +A MN R G GV V G ++ GG+ G+ + +E
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
Query: 579 YDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEF-LNTVEVYNLESNEWSP 635
+DP N+W+++GNM R G + IY +GG L + EVY+ S WSP
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSP 467
Score = 90.9 bits (224), Expect = 3e-18
Identities = 51/214 (23%), Positives = 103/214 (48%), Gaps = 1/214 (0%)
Query: 9 FEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPH 68
F + + +A++N +R FCDV+LQV AHR VLA SPY +F
Sbjct: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73
Query: 69 GISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSR 128
V + ++LL++ YT + V+++ AA L++ V +C ++L +
Sbjct: 74 SKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQ 133
Query: 129 MDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVC 187
+D +CI F+ + LL + YI H L++ EEFL L + +L +++ + +
Sbjct: 134 IDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELS 193
Query: 188 LPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQ 221
+ +++ + W+ + + + + E+++ ++
Sbjct: 194 IEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIR 227
Score = 73.9 bits (180), Expect = 4e-13
Identities = 51/182 (28%), Positives = 84/182 (46%), Gaps = 17/182 (9%)
Query: 286 KHEWKIVASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDE 345
+++W++V + S + C + I+ + + S LSK S
Sbjct: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWS------- 466
Query: 346 LIEKPMSPMQYARSGLGTAEMNGKLIAAGGYNR-EECLRTVECYNPHTDHWSFLAPMRTP 404
P+ PM R+ LG A +N + + GG+N ++ L TVE Y+ + W +A M+ P
Sbjct: 467 ----PLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVP 522
Query: 405 RARFQMAVLMGQLYVVGGSNGHSDDLSCG-----EMYDSNIDDWIPVPELRTNRCNAGVC 459
RA + + G LYV GG + D L+ G E+Y+ + D W + + T+RC GV
Sbjct: 523 RAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVA 582
Query: 460 AL 461
L
Sbjct: 583 VL 584
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 150 bits (380), Expect = 3e-36
Identities = 120/549 (21%), Positives = 226/549 (41%), Gaps = 34/549 (6%)
Query: 10 EDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHG 69
E+ + + +N +RK CDV L V ++ AHR VLA S + +F ++
Sbjct: 22 EEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESK 81
Query: 70 ISHVKFDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRM 129
V+ D P+ +E L+ +AYTA++ + V+ + AA + +++ VK++C D+L ++
Sbjct: 82 SFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQV 141
Query: 130 DVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCL 188
D ++C+ A C+ L D +I +H ++ + +EFL+L ++ +L +D + +
Sbjct: 142 DASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTV 201
Query: 189 PSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSAD--------HKLLDGN----- 235
+ ++Y + W++ + +++ +V+ S + L+ N
Sbjct: 202 RAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLK 261
Query: 236 -LLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVAS 294
++ G S +D + V PR H + G + W +
Sbjct: 262 MVISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRC 321
Query: 295 EKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPM 354
C+ D + ++ Q P + + + + +D K P
Sbjct: 322 PFEKRRDAACV-FWDNVVYIL-----GGSQLFP-----IKRMDCYNVVKDSWYSKLGPPT 370
Query: 355 QYARSGLGTAEMNGKLIAAGGYN-REECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVL 413
R L GK+ +GG L ECY+ T+ W M T R M
Sbjct: 371 --PRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEA 428
Query: 414 MGQLYVVGGSNGHSDD---LSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGG 470
G +YV GGS G++ L+ E+YD + W + + R N G+ + K++ VGG
Sbjct: 429 NGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGG 488
Query: 471 SDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVE 530
+ G GL N + +D W +P+ + +G +Y++ G + L +
Sbjct: 489 QNGLG--GLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHIL 546
Query: 531 RYNPENNTW 539
YN E + W
Sbjct: 547 EYNTETDKW 555
Score = 115 bits (287), Expect = 2e-25
Identities = 78/273 (28%), Positives = 120/273 (43%), Gaps = 11/273 (4%)
Query: 374 GGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCG 433
GG + C +NP W+ + R +Y++GGS +
Sbjct: 299 GGSQPQSC----RYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP--IKRM 352
Query: 434 EMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWT 493
+ Y+ D W T R + CA GK+Y GGS+ G L + +D T+ W
Sbjct: 353 DCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSE-VGNSALYLFECYDTRTESWH 411
Query: 494 SCAPLNIRRHQSAVCELGGYLYIIGGA----ESWNCLNTVERYNPENNTWTLIAPMNVAR 549
+ + +R + E G +Y+ GG+ S LN+ E Y+P TWT + PM AR
Sbjct: 412 TKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEAR 471
Query: 550 RGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIY 609
+ G+ + K+F GG +G + VE YD NEWKM+ M A VG+ +Y
Sbjct: 472 KNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVY 531
Query: 610 AVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF 642
+ GF G L + YN E+++W +K+ F
Sbjct: 532 VLAGFQGVGRLGHILEYNTETDKWVANSKVRAF 564
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/221 (24%), Positives = 87/221 (39%), Gaps = 57/221 (25%)
Query: 464 KLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESW 523
++ + GGS P ++C F+P WT +R +A +YI+GG++ +
Sbjct: 294 RIALFGGSQP------QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLF 347
Query: 524 -----NCLNTV------------------------------------------ERYNPEN 536
+C N V E Y+
Sbjct: 348 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 407
Query: 537 NTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSH----AISCVEMYDPTRNEWKMMGNM 592
+W M R G+ NG ++VCGG G++ ++ E+YDP W + M
Sbjct: 408 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 467
Query: 593 TSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEW 633
R N G+ V + I+AVGG +G L+ VE Y+++ NEW
Sbjct: 468 IEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEW 508
Score = 38.9 bits (89), Expect = 0.015
Identities = 27/100 (27%), Positives = 43/100 (43%), Gaps = 1/100 (1%)
Query: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQM 410
+ PM AR G + K+ A GG N L VE Y+ + W ++PM +
Sbjct: 464 LCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKC 523
Query: 411 AVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELR 450
A + +YV+ G G L Y++ D W+ ++R
Sbjct: 524 AAVGSIVYVLAGFQG-VGRLGHILEYNTETDKWVANSKVR 562
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 150 bits (378), Expect = 5e-36
Identities = 133/518 (25%), Positives = 207/518 (39%), Gaps = 73/518 (14%)
Query: 22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPE 81
L LR GQ DV L + AH+ VLA CS Y +F ++ ++
Sbjct: 53 LATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSAR 112
Query: 82 AVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFA 141
+ ++++AY+A++ D + V+DV AA L+M V ++C ++L + M V +C++ A
Sbjct: 113 GLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMA 172
Query: 142 SCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDN-VCLPSNGKLYTKVIN 200
+ + L VDA+ H LQI+EEE+FL+LP +L L+ N + + L+ +
Sbjct: 173 TTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVR 232
Query: 201 WVQRSIWENGDS-------------LEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSD 247
W+Q + EL++ VQTL + L LL E F
Sbjct: 233 WLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLL----EAFNYQ 288
Query: 248 DDHIQFVQKKPPRENGHKQISS----------SSTGCLSSPNATVQSPKHEWKIVASEKT 297
+ + + PR + S S +SS + P +E
Sbjct: 289 VLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEME 348
Query: 298 SNNTYLCLAVLDGIFCVI------FLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIE--- 348
++ C+AVLD V + G + + P L++ L + Q+ I+
Sbjct: 349 VGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQL 408
Query: 349 KPMSPMQYARSGLGT--------------------------------AEMNGKLIAAGGY 376
+ M YA G A G+L +GGY
Sbjct: 409 NVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGGY 468
Query: 377 N-REECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSD---DLSC 432
E + + CY+P D W F APM PR M G++Y +GG H D D+
Sbjct: 469 GISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDRCFDVLA 528
Query: 433 GEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGG 470
E Y D W V +R + AG C L K+YIVGG
Sbjct: 529 VEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGG 566
Score = 104 bits (259), Expect = 3e-22
Identities = 70/223 (31%), Positives = 109/223 (48%), Gaps = 14/223 (6%)
Query: 388 YNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVP 447
Y+PH + W L M+ R +FQ+ VL G +Y GG N + L+ E Y ++W
Sbjct: 386 YDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRN-RAGSLASVERYCPRRNEWGYAC 444
Query: 448 ELRTNRCNAGVCALNGKLYIVGGSDPYG--QKGLKNCDVFDPVTKLWTSCAPLNIRRHQS 505
L+ A G+LYI GG YG + K +DPV W AP++ R
Sbjct: 445 SLKRRTWGHAGAASGGRLYISGG---YGISVEDKKALHCYDPVADQWEFKAPMSEPRVLH 501
Query: 506 AVCELGGYLYIIGGAESW--NCLNT--VERYNPENNTWTLIAPMNVARRGAGVAVLNGKL 561
A+ GG +Y +GG C + VE Y PE + WT ++PM + AG +L K+
Sbjct: 502 AMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKI 561
Query: 562 FVCGGFDG--SHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIA 602
++ GG++ ++ V++Y+ +EW+ ++ P S AGIA
Sbjct: 562 YIVGGYNWRLNNVTGIVQVYNTDTDEWER--DLHFPESFAGIA 602
Score = 85.5 bits (210), Expect = 1e-16
Identities = 69/256 (26%), Positives = 110/256 (42%), Gaps = 15/256 (5%)
Query: 390 PHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSN-----GHSDDLSCGEMYDSNIDDWI 444
P H+ L M + +AVL +YV GG + G +C YD +++ W+
Sbjct: 336 PGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYR-YDPHLNRWL 394
Query: 445 PVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQ 504
+ ++ +R + L G +Y GG + G L + + + P W L R
Sbjct: 395 RLQAMQESRIQFQLNVLCGMVYATGGRNRAGS--LASVERYCPRRNEWGYACSLKRRTWG 452
Query: 505 SAVCELGGYLYIIGG-AESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFV 563
A GG LYI GG S + Y+P + W APM+ R + G+++
Sbjct: 453 HAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYA 512
Query: 564 CGG----FDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDG--N 617
GG D + VE Y P ++W + M + +S AG + IY VGG++ N
Sbjct: 513 LGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLN 572
Query: 618 EFLNTVEVYNLESNEW 633
V+VYN +++EW
Sbjct: 573 NVTGIVQVYNTDTDEW 588
Score = 75.5 bits (184), Expect = 1e-13
Identities = 53/198 (26%), Positives = 83/198 (41%), Gaps = 14/198 (7%)
Query: 448 ELRTNRCNAGVCALNGKLYIVGGSDPY---GQKGLKNCDVFDPVTKLWTSCAPLNIRRHQ 504
E+ + V L+ +Y+ GG G+ + C +DP W + R Q
Sbjct: 346 EMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQ 405
Query: 505 SAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVC 564
+ L G +Y GG L +VERY P N W + G A G+L++
Sbjct: 406 FQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYIS 465
Query: 565 GGF----DGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGG----FDG 616
GG+ + A+ C YDP ++W+ M+ PR + G IYA+GG D
Sbjct: 466 GGYGISVEDKKALHC---YDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRMDHVDR 522
Query: 617 NEFLNTVEVYNLESNEWS 634
+ VE Y E+++W+
Sbjct: 523 CFDVLAVEYYVPETDQWT 540
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 149 bits (377), Expect = 6e-36
Identities = 136/590 (23%), Positives = 235/590 (39%), Gaps = 57/590 (9%)
Query: 8 MFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDP 67
+F ++ +S + LN LR+ F DV L HRAVLA CS Y +F+
Sbjct: 22 LFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKE 81
Query: 68 HGISHVKFDD-LNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLL 126
S V FD+ ++PE +E+LL+YAY++++ ++E + + A L+ ++ C ++L
Sbjct: 82 SQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLE 141
Query: 127 SRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPR-LKLEVMLEDN 185
+ T+C+ + ++L + I + E+FL+LP+ + ++++ +
Sbjct: 142 KNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEE 201
Query: 186 VCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFG 245
+ +Y INW+ + + L EL++ V+ A + L++ A
Sbjct: 202 LETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIY------LMENVA---- 251
Query: 246 SDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCL 305
+++ ++ K+I + C K+ + T LC
Sbjct: 252 --------MEELITKQRKSKEIVEEAIRC---------------KLKILQNDGVVTSLCA 288
Query: 306 AVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAE 365
+ L G+ T K + + E+I P + + R
Sbjct: 289 RPRKTGHALFLLGGQ---------TFMCDKLYLVDQKAKEII--PKADIPSPRKEFSACA 337
Query: 366 MNGKLIAAGGYNREECL-RTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSN 424
+ K+ GG E + + V Y+ + WS APM R A L LYVVGG
Sbjct: 338 IGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHT 397
Query: 425 GHSDDLSCG--------EMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQ 476
+ L E YD I+ W V LR NA V + KL+ GG+
Sbjct: 398 AATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHD 457
Query: 477 KGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPEN 536
K L +D WT A +A LG ++I+GG ++ + ++N E
Sbjct: 458 K-LPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAY-KFNSET 515
Query: 537 NTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEW 586
WT + + R KL+V GG+ G ++ YDPT + W
Sbjct: 516 YQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVW 565
Score = 92.4 bits (228), Expect = 1e-18
Identities = 66/229 (28%), Positives = 102/229 (44%), Gaps = 17/229 (7%)
Query: 417 LYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQ 476
L+++GG D L + D + IP ++ + R CA+ K+YI GG +
Sbjct: 297 LFLLGGQTFMCDKLY---LVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRG--SE 351
Query: 477 KGL-KNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGG---------AESWNCL 526
G+ K+ V+D + + W+ AP+ + R EL LY++GG A L
Sbjct: 352 NGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSL 411
Query: 527 NTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSH-AISCVEMYDPTRNE 585
VE Y+P N WT++AP+ A V KLF GG SH + V+ YD N
Sbjct: 412 KQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENR 471
Query: 586 WKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
W + P A +GN I+ +GG D + +N E+ +W+
Sbjct: 472 WTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFSACSAYKFNSETYQWT 519
Score = 91.3 bits (225), Expect = 3e-18
Identities = 69/252 (27%), Positives = 109/252 (43%), Gaps = 15/252 (5%)
Query: 399 APMRTPRARFQMAVLMGQLYVVGG---SNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCN 455
A + +PR F + ++Y+ GG NG S D+ +YD+ ++W + R
Sbjct: 324 ADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVW---VYDTLHEEWSKAAPMLVARFG 380
Query: 456 AGVCALNGKLYIVGGSDPYG-------QKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVC 508
G L LY+VGG LK + +DP WT APL +AV
Sbjct: 381 HGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVV 440
Query: 509 ELGGYLYIIGGAE-SWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGF 567
L+ GG S + L V+ Y+ N WT+ A R AVL ++F+ GG
Sbjct: 441 SAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGD 500
Query: 568 DGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYN 627
A S + T +W +G++T+ R + GN +Y VGG+ G + T++ Y+
Sbjct: 501 TEFSACSAYKFNSETY-QWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYD 559
Query: 628 LESNEWSPYTKI 639
+ W+ T +
Sbjct: 560 PTLDVWNSITTV 571
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 147 bits (371), Expect = 3e-35
Identities = 138/542 (25%), Positives = 231/542 (42%), Gaps = 43/542 (7%)
Query: 22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPE 81
L LR + DV L V G E+ HR +LA SPY +F D + V+ D+ P
Sbjct: 5 LQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPA 64
Query: 82 AVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFA 141
V L+++ YT +L + V+ + A +L V++VCG YL ++D +C+ F
Sbjct: 65 VVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFG 124
Query: 142 SCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNV--CLPSNGKLYTKVI 199
G + K A+++E+ ++ E+EFL+LPR +L L ++ P +L ++
Sbjct: 125 EQQGLLGVAAKAWAFLRENFEAVAREDEFLQLPRERLVTCLAGDLLQVQPEQSRL-EALM 183
Query: 200 NWVQRSIWENGDSLEELME--EVQTLYYSADHKLLDGNLLDGQAEVF------GSDDDHI 251
WV+ L EL+ + + +LL L ++E G D +
Sbjct: 184 RWVRHDPQARAAHLPELLSLVHLDAVPRPCVQQLLASEPLIQESEACRAALSQGHDGAPL 243
Query: 252 QFVQK--KPPRENGHKQISSSSTGCLSSPN----ATVQSPKHEWKIVASEKTSNNTYLCL 305
QK + G + + G +P A S W + + L
Sbjct: 244 ALQQKLEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAKRWMALPDFPDYHKWGFSL 303
Query: 306 AVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAE 365
A L+ V + + T T +++ F ++ E KP++PM R+ +A
Sbjct: 304 AALNNNIYV-----TGGSRGTKTDTWSTTQAWCFPLK--EASWKPVAPMLKPRTNHASAA 356
Query: 366 MNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNG 425
+NG++ GG + + VE Y+P+TD W+ ++P + F A G+LY+VG S
Sbjct: 357 LNGEIYVIGGTTLD--VVEVESYDPYTDSWTPVSPALKYVSNFSAAGCRGRLYLVGSSAC 414
Query: 426 HSDDLSCGEMYDSNIDDW--IPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCD 483
+ L+ + Y+ D W I P L + AL+G+LY++G + K
Sbjct: 415 KYNALAL-QCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN-------TKKVY 466
Query: 484 VFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLN-----TVERYNPENNT 538
V+DP LW + A+ LG LY+ GG W + +E Y+ +T
Sbjct: 467 VYDPGANLWQKVQSQHSLHENGALVPLGDALYVTGG--RWQGMEGDYHVEMEAYDTVRDT 524
Query: 539 WT 540
WT
Sbjct: 525 WT 526
Score = 84.7 bits (208), Expect = 2e-16
Identities = 66/238 (27%), Positives = 115/238 (48%), Gaps = 23/238 (9%)
Query: 408 FQMAVLMGQLYVVGGSNG-HSDDLSCGEMYDSNIDD--WIPVPELRTNRCNAGVCALNGK 464
F +A L +YV GGS G +D S + + + + W PV + R N ALNG+
Sbjct: 301 FSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGE 360
Query: 465 LYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPL--NIRRHQSAVCELGGYLYIIGGAE- 521
+Y++GG+ + + +DP T WT +P + +A C G LY++G +
Sbjct: 361 IYVIGGTT----LDVVEVESYDPYTDSWTPVSPALKYVSNFSAAGCR--GRLYLVGSSAC 414
Query: 522 SWNCLNTVERYNPENNTWTLIAPMNVAR--RGAGVAVLNGKLFVCGGFDGSHAISCVEMY 579
+N L ++ YNP + W++IA + + A L+G+L++ G D + V +Y
Sbjct: 415 KYNAL-ALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIG--DNTKK---VYVY 468
Query: 580 DPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGG-FDGNE--FLNTVEVYNLESNEWS 634
DP N W+ + + S N + +G+ +Y GG + G E + +E Y+ + W+
Sbjct: 469 DPGANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWT 526
Score = 60.1 bits (144), Expect = 6e-09
Identities = 49/205 (23%), Positives = 86/205 (41%), Gaps = 16/205 (7%)
Query: 436 YDSNIDDWIPVPELRT-NRCNAGVCALNGKLYIVGGSDPYGQK----GLKNCDVFDPVTK 490
Y+S W+ +P+ ++ + ALN +Y+ GGS G K F
Sbjct: 280 YNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSR--GTKTDTWSTTQAWCFPLKEA 337
Query: 491 LWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARR 550
W AP+ R A L G +Y+IGG + VE Y+P ++WT ++P
Sbjct: 338 SWKPVAPMLKPRTNHASAALNGEIYVIGGTTL--DVVEVESYDPYTDSWTPVSPALKYVS 395
Query: 551 GAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPR--SNAGIATVGNTI 608
A G+L++ G + ++ Y+P + W ++ + P+ S+ A + +
Sbjct: 396 NFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGEL 455
Query: 609 YAVGGFDGNEFLNTVEVYNLESNEW 633
Y +G + V VY+ +N W
Sbjct: 456 YLIG-----DNTKKVYVYDPGANLW 475
>gi|11545731 gigaxonin [Homo sapiens]
Length = 597
Score = 146 bits (369), Expect = 5e-35
Identities = 135/585 (23%), Positives = 247/585 (42%), Gaps = 70/585 (11%)
Query: 22 LNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEI--FNSDSDPHGISHVKFDDLN 79
L++ R+ +FCD L + G E+ + +LA SPY+ +N D ++ + ++
Sbjct: 20 LSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTYKIELEGIS 79
Query: 80 PEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRN 139
+ +L+Y ++ Q++ +++ ++DV AA L + +K +C ++L + +CI R+
Sbjct: 80 VMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENCIGIRD 139
Query: 140 FA--SCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKL-EVMLEDNVCLPSNGKLYT 196
FA C+ L Y++ H +S EEFL+L KL EV+ + + + + ++
Sbjct: 140 FALHYCLHHVHYL--ATEYLETHFRDVSSTEEFLELSPQKLKEVISLEKLNVGNERYVFE 197
Query: 197 KVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNLLDGQAEVFGSDDDHIQFVQK 256
VI W+ ++++M L+ S LD + L Q +
Sbjct: 198 AVIRWIAHDTEIRKVHMKDVM---SALWVSG----LDSSYLREQ-------------MLN 237
Query: 257 KPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIF 316
+P K+ S N + P+ ++A+ K + C++
Sbjct: 238 EPLVREIVKECS----------NIPLSQPQQGEAMLANFKPRGYSE----------CIVT 277
Query: 317 LHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGY 376
+ G PT+ + L ++ + IE ++P+ R G G L GG
Sbjct: 278 VGGEERVSRKPTAAMRCMCPL-YDPNRQLWIE--LAPLSMPRINHGVLSAEGFLFVFGGQ 334
Query: 377 N-REECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEM 435
+ ++ L + E Y+P + W+ L PM R F + + G LY++GG +G + +S E
Sbjct: 335 DENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISM-EC 393
Query: 436 YDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSC 495
YD W P+L R A+ K+Y +GG YG K ++ + +DP T+ WT+
Sbjct: 394 YDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGGS-YG-KLFESVECYDPRTQQWTAI 451
Query: 496 APLNIRRHQSAVCELGGYLYIIG---------GAESWNCLNTVERYNPENNTWTLIAPMN 546
PL RR + C + LY+ G G+E C + E Y+ E W + N
Sbjct: 452 CPLKERRFGAVACGVAMELYVFGGVRSREDAQGSEMVTCKS--EFYHDEFKRWIYLNDQN 509
Query: 547 VARRGA-----GVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEW 586
+ + G + ++V G D V + + W
Sbjct: 510 LCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKRSTGTW 554
Score = 120 bits (302), Expect = 3e-27
Identities = 85/305 (27%), Positives = 133/305 (43%), Gaps = 23/305 (7%)
Query: 350 PMSPMQYARSGLGTAEMNGK---LIAAGGYNREECLRT--VEC----YNPHTDHWSFLAP 400
P+S Q + L + G ++ GG R T + C Y+P+ W LAP
Sbjct: 252 PLSQPQQGEAMLANFKPRGYSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWIELAP 311
Query: 401 MRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCA 460
+ PR + G L+V GG + + LS GE YD + + W +P + R N G+
Sbjct: 312 LSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNFGIVE 371
Query: 461 LNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520
++G LYI+GG D G+K L + + +D +K WT L + R + +Y +GG
Sbjct: 372 IDGMLYILGGED--GEKELISMECYDIYSKTWTKQPDLTMVRKIGCYAAMKKKIYAMGGG 429
Query: 521 ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGF------DGSHAIS 574
+VE Y+P WT I P+ R GA + +L+V GG GS ++
Sbjct: 430 SYGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGGVRSREDAQGSEMVT 489
Query: 575 C-VEMYDPTRNEWKMMG--NMTSPRSNA---GIATVGNTIYAVGGFDGNEFLNTVEVYNL 628
C E Y W + N+ P S++ G +G +IY +G D + V +
Sbjct: 490 CKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAVPIGASIYVIGDLDTGTNYDYVREFKR 549
Query: 629 ESNEW 633
+ W
Sbjct: 550 STGTW 554
Score = 105 bits (263), Expect = 1e-22
Identities = 51/154 (33%), Positives = 83/154 (53%), Gaps = 1/154 (0%)
Query: 482 CDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA-ESWNCLNTVERYNPENNTWT 540
C ++DP +LW APL++ R V G+L++ GG E+ L++ E+Y+P+ NTWT
Sbjct: 296 CPLYDPNRQLWIELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWT 355
Query: 541 LIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAG 600
+ PMN AR G+ ++G L++ GG DG + +E YD W ++T R
Sbjct: 356 ALPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGC 415
Query: 601 IATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWS 634
A + IYA+GG + +VE Y+ + +W+
Sbjct: 416 YAAMKKKIYAMGGGSYGKLFESVECYDPRTQQWT 449
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/227 (24%), Positives = 96/227 (42%), Gaps = 17/227 (7%)
Query: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQM 410
+ PM AR G E++G L GG + E+ L ++ECY+ ++ W+ + R
Sbjct: 357 LPPMNEARHNFGIVEIDGMLYILGGEDGEKELISMECYDIYSKTWTKQPDLTMVRKIGCY 416
Query: 411 AVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGG 470
A + ++Y +GG + + E YD W + L+ R A C + +LY+ GG
Sbjct: 417 AAMKKKIYAMGGGS-YGKLFESVECYDPRTQQWTAICPLKERRFGAVACGVAMELYVFGG 475
Query: 471 ----SDPYGQKGLK-NCDVFDPVTKLW------TSCAPLNIRRHQSAVCELGGYLYIIGG 519
D G + + + + K W C P + AV +G +Y+IG
Sbjct: 476 VRSREDAQGSEMVTCKSEFYHDEFKRWIYLNDQNLCIPASSSFVYGAV-PIGASIYVIGD 534
Query: 520 AESWNCLNTVERYNPENNTW---TLIAPMNVARRG-AGVAVLNGKLF 562
++ + V + TW + P ++ R G A + + N KLF
Sbjct: 535 LDTGTNYDYVREFKRSTGTWHHTKPLLPSDLRRTGCAALRIANCKLF 581
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 146 bits (368), Expect = 7e-35
Identities = 143/615 (23%), Positives = 240/615 (39%), Gaps = 63/615 (10%)
Query: 5 GYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFN-- 62
G F D + +LN R++ F D+++ V G E H+ VLA CS Y ++
Sbjct: 302 GKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRS 361
Query: 63 -SDSDPHGISHVKF--DDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQ 119
DS G ++ +L + +E+LL + YT L D K + AA K + +
Sbjct: 362 VQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCK 421
Query: 120 VCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLE 179
VC +L ++ ++C+ A M S L + A+ + +++ +EE L + +
Sbjct: 422 VCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISK---- 477
Query: 180 VMLEDNVCLPSNGKLYTK--------VINWVQRSIWENGDSLEELMEEVQTLYYSADHKL 231
+D + SN L TK VI W+++ EL+ V+ + + L
Sbjct: 478 ---DDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLL 534
Query: 232 LDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKI 291
N++D + ++ SS C N + H
Sbjct: 535 ---NVVDNE-------------------------ELIKSSEACRDLVNEAKRY--HMLPH 564
Query: 292 VASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPM 351
E + T L+ G+ VI L G Q + L + Q ++
Sbjct: 565 ARQEMQTPRTRPRLSA--GVAEVIVLVGGR--QMVGMTQRSLVAVTCWNPQNNKWYPLAS 620
Query: 352 SPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMA 411
P Y R + +GG L V CY D+W+ ++ M PR R
Sbjct: 621 LPF-YDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSL 679
Query: 412 VLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGS 471
V G++Y +GG G + ++ E YD+ + W V L +A GK+Y+ GG
Sbjct: 680 VYDGKIYTLGGL-GVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV 738
Query: 472 DPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVER 531
+ G + + P T W+ I + L G+++I+GGA +
Sbjct: 739 NEAG-RAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYA----RATTI 793
Query: 532 YNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSH--AISCVEMYDPTRNEWKMM 589
Y+PE MN +R+ VL+GK++ GG S A+ +E Y+PT N W ++
Sbjct: 794 YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLL 853
Query: 590 GNMTSPRSNAGIATV 604
+M P G +
Sbjct: 854 PHMPCPVFRHGCVVI 868
Score = 109 bits (272), Expect = 9e-24
Identities = 83/297 (27%), Positives = 129/297 (43%), Gaps = 22/297 (7%)
Query: 348 EKPMSPMQYARSGLGTAEMNGKLIAAGGYNR----EECLRTVECYNPHTDHWSFLAPMRT 403
++ +P R G AE+ ++ GG + L V C+NP + W LA +
Sbjct: 567 QEMQTPRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPF 623
Query: 404 PRARFQMAVLMG-QLYVVGG--SNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCA 460
F V G +Y+ GG S D+ C Y S +D+W V + RC
Sbjct: 624 YDREFFSVVSAGDNIYLSGGMESGVTLADVWC---YMSLLDNWNLVSRMTVPRCRHNSLV 680
Query: 461 LNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520
+GK+Y +GG G + + + +D +T W + APL H +A GG +Y+ GG
Sbjct: 681 YDGKIYTLGGLGVAG--NVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV 738
Query: 521 -ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMY 579
E+ ++ Y P+ NTW+ I + + A LNG +F+ G G++A +Y
Sbjct: 739 NEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILG---GAYA-RATTIY 794
Query: 580 DPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNE--FLNTVEVYNLESNEWS 634
DP + K NM R + IYA GG +E L +E Y +N W+
Sbjct: 795 DPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWT 851
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 146 bits (368), Expect = 7e-35
Identities = 143/615 (23%), Positives = 240/615 (39%), Gaps = 63/615 (10%)
Query: 5 GYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFN-- 62
G F D + +LN R++ F D+++ V G E H+ VLA CS Y ++
Sbjct: 302 GKYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRS 361
Query: 63 -SDSDPHGISHVKF--DDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQ 119
DS G ++ +L + +E+LL + YT L D K + AA K + +
Sbjct: 362 VQDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCK 421
Query: 120 VCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLE 179
VC +L ++ ++C+ A M S L + A+ + +++ +EE L + +
Sbjct: 422 VCVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISK---- 477
Query: 180 VMLEDNVCLPSNGKLYTK--------VINWVQRSIWENGDSLEELMEEVQTLYYSADHKL 231
+D + SN L TK VI W+++ EL+ V+ + + L
Sbjct: 478 ---DDFIAYVSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLL 534
Query: 232 LDGNLLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKI 291
N++D + ++ SS C N + H
Sbjct: 535 ---NVVDNE-------------------------ELIKSSEACRDLVNEAKRY--HMLPH 564
Query: 292 VASEKTSNNTYLCLAVLDGIFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPM 351
E + T L+ G+ VI L G Q + L + Q ++
Sbjct: 565 ARQEMQTPRTRPRLSA--GVAEVIVLVGGR--QMVGMTQRSLVAVTCWNPQNNKWYPLAS 620
Query: 352 SPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMA 411
P Y R + +GG L V CY D+W+ ++ M PR R
Sbjct: 621 LPF-YDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSL 679
Query: 412 VLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGS 471
V G++Y +GG G + ++ E YD+ + W V L +A GK+Y+ GG
Sbjct: 680 VYDGKIYTLGGL-GVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV 738
Query: 472 DPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVER 531
+ G + + P T W+ I + L G+++I+GGA +
Sbjct: 739 NEAG-RAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYA----RATTI 793
Query: 532 YNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSH--AISCVEMYDPTRNEWKMM 589
Y+PE MN +R+ VL+GK++ GG S A+ +E Y+PT N W ++
Sbjct: 794 YDPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWTLL 853
Query: 590 GNMTSPRSNAGIATV 604
+M P G +
Sbjct: 854 PHMPCPVFRHGCVVI 868
Score = 109 bits (272), Expect = 9e-24
Identities = 83/297 (27%), Positives = 129/297 (43%), Gaps = 22/297 (7%)
Query: 348 EKPMSPMQYARSGLGTAEMNGKLIAAGGYNR----EECLRTVECYNPHTDHWSFLAPMRT 403
++ +P R G AE+ ++ GG + L V C+NP + W LA +
Sbjct: 567 QEMQTPRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPF 623
Query: 404 PRARFQMAVLMG-QLYVVGG--SNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCA 460
F V G +Y+ GG S D+ C Y S +D+W V + RC
Sbjct: 624 YDREFFSVVSAGDNIYLSGGMESGVTLADVWC---YMSLLDNWNLVSRMTVPRCRHNSLV 680
Query: 461 LNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGA 520
+GK+Y +GG G + + + +D +T W + APL H +A GG +Y+ GG
Sbjct: 681 YDGKIYTLGGLGVAG--NVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGV 738
Query: 521 -ESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSHAISCVEMY 579
E+ ++ Y P+ NTW+ I + + A LNG +F+ G G++A +Y
Sbjct: 739 NEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILG---GAYA-RATTIY 794
Query: 580 DPTRNEWKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNE--FLNTVEVYNLESNEWS 634
DP + K NM R + IYA GG +E L +E Y +N W+
Sbjct: 795 DPEKGNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPALGNMEAYEPTTNTWT 851
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 143 bits (361), Expect = 4e-34
Identities = 116/527 (22%), Positives = 217/527 (41%), Gaps = 34/527 (6%)
Query: 32 CDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGISHVKFDDLNPEAVEVLLNYAY 91
CDV L V ++ AHR VLA S + +F ++ V+ D P+ +E L+ +AY
Sbjct: 22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAY 81
Query: 92 TAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLN 151
TA++ + V+ + AA + +++ VK++C D+L ++D ++C+ A C+ L
Sbjct: 82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKA 141
Query: 152 KVDAYIQEHLLQISEEEEFLKLPRLKLEVML-EDNVCLPSNGKLYTKVINWVQRSIWENG 210
D +I +H ++ + +EFL+L ++ +L +D + + + ++Y + W++
Sbjct: 142 TADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 201
Query: 211 DSLEELMEEVQTLYYSAD--------HKLLDGN------LLDGQAEVFGSDDDHIQFVQK 256
+ +++ +V+ S + L+ N ++ G S +D + V
Sbjct: 202 PFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDG 261
Query: 257 KPPRENGHKQISSSSTGCLSSPNATVQSPKHEWKIVASEKTSNNTYLCLAVLDGIFCVIF 316
PR H + G + W + C+ D + ++
Sbjct: 262 TRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYIL- 319
Query: 317 LHGRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGY 376
Q P + + + + +D K P R L GK+ +GG
Sbjct: 320 ----GGSQLFP-----IKRMDCYNVVKDSWYSKLGPPT--PRDSLAACAAEGKIYTSGGS 368
Query: 377 N-REECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDD---LSC 432
L ECY+ T+ W M T R M G +YV GGS G++ L+
Sbjct: 369 EVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNS 428
Query: 433 GEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLW 492
E+YD + W + + R N G+ + K++ VGG + G GL N + +D W
Sbjct: 429 CEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLG--GLDNVEYYDIKLNEW 486
Query: 493 TSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTW 539
+P+ + +G +Y++ G + L + YN E + W
Sbjct: 487 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
Score = 115 bits (287), Expect = 2e-25
Identities = 78/273 (28%), Positives = 120/273 (43%), Gaps = 11/273 (4%)
Query: 374 GGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCG 433
GG + C +NP W+ + R +Y++GGS +
Sbjct: 277 GGSQPQSC----RYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP--IKRM 330
Query: 434 EMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLWT 493
+ Y+ D W T R + CA GK+Y GGS+ G L + +D T+ W
Sbjct: 331 DCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSE-VGNSALYLFECYDTRTESWH 389
Query: 494 SCAPLNIRRHQSAVCELGGYLYIIGGA----ESWNCLNTVERYNPENNTWTLIAPMNVAR 549
+ + +R + E G +Y+ GG+ S LN+ E Y+P TWT + PM AR
Sbjct: 390 TKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEAR 449
Query: 550 RGAGVAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNTIY 609
+ G+ + K+F GG +G + VE YD NEWKM+ M A VG+ +Y
Sbjct: 450 KNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVY 509
Query: 610 AVGGFDGNEFLNTVEVYNLESNEWSPYTKIFQF 642
+ GF G L + YN E+++W +K+ F
Sbjct: 510 VLAGFQGVGRLGHILEYNTETDKWVANSKVRAF 542
Score = 69.7 bits (169), Expect = 8e-12
Identities = 54/221 (24%), Positives = 87/221 (39%), Gaps = 57/221 (25%)
Query: 464 KLYIVGGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESW 523
++ + GGS P ++C F+P WT +R +A +YI+GG++ +
Sbjct: 272 RIALFGGSQP------QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLF 325
Query: 524 -----NCLNTV------------------------------------------ERYNPEN 536
+C N V E Y+
Sbjct: 326 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 385
Query: 537 NTWTLIAPMNVARRGAGVAVLNGKLFVCGGFDGSH----AISCVEMYDPTRNEWKMMGNM 592
+W M R G+ NG ++VCGG G++ ++ E+YDP W + M
Sbjct: 386 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 445
Query: 593 TSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEW 633
R N G+ V + I+AVGG +G L+ VE Y+++ NEW
Sbjct: 446 IEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEW 486
Score = 38.9 bits (89), Expect = 0.015
Identities = 27/100 (27%), Positives = 43/100 (43%), Gaps = 1/100 (1%)
Query: 351 MSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQM 410
+ PM AR G + K+ A GG N L VE Y+ + W ++PM +
Sbjct: 442 LCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKC 501
Query: 411 AVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELR 450
A + +YV+ G G L Y++ D W+ ++R
Sbjct: 502 AAVGSIVYVLAGFQG-VGRLGHILEYNTETDKWVANSKVR 540
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,070,626
Number of Sequences: 37866
Number of extensions: 1200219
Number of successful extensions: 4336
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 157
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 2761
Number of HSP's gapped (non-prelim): 525
length of query: 642
length of database: 18,247,518
effective HSP length: 109
effective length of query: 533
effective length of database: 14,120,124
effective search space: 7526026092
effective search space used: 7526026092
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.