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Search of human proteins with 24432026
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24432026 kelch-like [Homo sapiens]
(634 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24432026 kelch-like [Homo sapiens] 1306 0.0
gi|45643138 kelch-like 13 [Homo sapiens] 341 1e-93
gi|24308181 kelch-like 9 [Homo sapiens] 338 1e-92
gi|8922854 kelch-like 26 [Homo sapiens] 325 6e-89
gi|31542246 kelch-like 36 [Homo sapiens] 311 9e-85
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 269 7e-72
gi|226442729 kelch-like 15 [Homo sapiens] 265 1e-70
gi|156616301 kelch-like 32 [Homo sapiens] 249 7e-66
gi|40807500 kelch-like 20 [Homo sapiens] 247 2e-65
gi|14780904 kelch-like 1 protein [Homo sapiens] 233 5e-61
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 231 2e-60
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 231 2e-60
gi|38194229 kelch-like 17 [Homo sapiens] 229 8e-60
gi|55741643 kelch-like 14 [Homo sapiens] 229 8e-60
gi|55925604 kelch-like 18 [Homo sapiens] 226 5e-59
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 216 7e-56
gi|109150407 kelch-like 6 [Homo sapiens] 213 4e-55
gi|223890235 intracisternal A particle-promoted polypeptide isof... 212 7e-55
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 211 2e-54
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 211 2e-54
gi|148664209 kelch-like 10 [Homo sapiens] 210 3e-54
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 209 8e-54
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 208 1e-53
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 208 1e-53
gi|166235129 kelch-like 3 [Homo sapiens] 208 1e-53
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 207 2e-53
gi|11056006 kelch-like 12 [Homo sapiens] 204 2e-52
gi|40018614 DRE1 protein [Homo sapiens] 189 5e-48
gi|34101268 kelch-like 8 [Homo sapiens] 185 1e-46
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 184 2e-46
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 1306 bits (3379), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 1 MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRH 60
MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRH
Sbjct: 1 MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRH 60
Query: 61 IEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNV 120
IEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNV
Sbjct: 61 IEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNV 120
Query: 121 QETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFV 180
QETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFV
Sbjct: 121 QETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFV 180
Query: 181 AFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKL 240
AFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKL
Sbjct: 181 AFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKL 240
Query: 241 LETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCV 300
LETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCV
Sbjct: 241 LETVRFPLMEAEVLQRLHDKLDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCV 300
Query: 301 VGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNV 360
VGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNV
Sbjct: 301 VGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNV 360
Query: 361 QGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYD 420
QGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYD
Sbjct: 361 QGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYD 420
Query: 421 PATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGP 480
PATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGP
Sbjct: 421 PATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGP 480
Query: 481 VRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIA 540
VRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIA
Sbjct: 481 VRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIA 540
Query: 541 VLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLE 600
VLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLE
Sbjct: 541 VLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLE 600
Query: 601 PPRGTPDRSQADPDFASEVMSVSDWEEFDNSSED 634
PPRGTPDRSQADPDFASEVMSVSDWEEFDNSSED
Sbjct: 601 PPRGTPDRSQADPDFASEVMSVSDWEEFDNSSED 634
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 341 bits (874), Expect = 1e-93
Identities = 205/596 (34%), Positives = 323/596 (54%), Gaps = 22/596 (3%)
Query: 27 YRSAQHSQALLRGLLALRDSGILFDVVLVVEGRH--IEAHRILLAASCDYFRGMFAGGLK 84
+ S HS +L+G LR G+L DV L+ HR+++A++ DYF+ MF GG+K
Sbjct: 69 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMK 128
Query: 85 EMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLM 144
E + + +HGVS + +I+ FIYT++L L++ N+Q+TL AA LQI ++ FC FL+
Sbjct: 129 EQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 188
Query: 145 SWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNR 204
S V +N ++V R+A ++L+ + + +++++LKNF A T ++ +LP E++ +LSSN
Sbjct: 189 SGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNS 248
Query: 205 LEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPS 264
L+ E E+++ + LE+ + D + KL++ +RFPLM + L +D
Sbjct: 249 LKHCTELELFKATCRW-LRLEEPRMDFAA-----KLMKNIRFPLMTPQELINYVQTVDFM 302
Query: 265 PLRDTVASALM----YHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKY 320
+T + L+ Y +QP +QS +T +RSD +V GG+ V+S + +
Sbjct: 303 RTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGV-LRQQLVVSKELRM 361
Query: 321 LNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNN--VQGFRAESRCWRYDPRHNR 378
+ EWK APR + GIAV+ NF+Y++GG +N +G A +R+DPR+N+
Sbjct: 362 YDEKAHEWKSLAPMDAPRYQH-GIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 420
Query: 379 WFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYA 438
W Q+ SL ++ + + Y+YAV GR+ +L VE Y+P TN W YVA + Y
Sbjct: 421 WMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYG 480
Query: 439 HAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVI 498
HAG G MYI+ G + + KE C+DP ++ W A R H M T+ +LYVI
Sbjct: 481 HAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVI 540
Query: 499 GGSN-NDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRG 557
GG++ DV YS QW+ + + G + G+AV +N+IYV+GG S N
Sbjct: 541 GGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 600
Query: 558 SRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLEPPRGTPDRSQADP 613
V YD +KD W + L S+ G+ AC LT + P TP S+ P
Sbjct: 601 CMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLT-----VFPPEETTPSPSRESP 651
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 338 bits (866), Expect = 1e-92
Identities = 208/597 (34%), Positives = 325/597 (54%), Gaps = 19/597 (3%)
Query: 27 YRSAQHSQALLRGLLALRDSGILFDVVLVV-EGRHI-EAHRILLAASCDYFRGMFAGGLK 84
+ S HS +L+G LR G+L DV LV +G I HR ++A++ DYF+ MF GG+K
Sbjct: 27 FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMK 86
Query: 85 EMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLM 144
E + + +HGV+ + +I+ FIYT++L L++ N+Q+TL AA LQI ++ FC FL+
Sbjct: 87 EQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 146
Query: 145 SWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNR 204
S V +N ++V R+A ++L + + ++ +ILKNF A T ++ +LP E++ +LSSN
Sbjct: 147 SGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNS 206
Query: 205 LEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPS 264
L+ E E+++ A + LE + D + KL++ +RFPLM + L +D
Sbjct: 207 LKHCTELELFKAACRW-LRLEDPRMDYAA-----KLMKNIRFPLMTPQDLINYVQTVDFM 260
Query: 265 PLRDTVASALM----YHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKY 320
+T + L+ Y +QP +QS +T +RSD +V GG+ V+S + +
Sbjct: 261 RTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGV-LRQQLVVSKELRM 319
Query: 321 LNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNN--VQGFRAESRCWRYDPRHNR 378
+ EW+ APR + GIAV+ NF+Y++GG +N +G A +R+DPR+N+
Sbjct: 320 YDERAQEWRSLAPMDAPRYQH-GIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 378
Query: 379 WFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYA 438
W Q+ SL ++ + + ++YAV GR +L VE Y+P N W+YVA + Y
Sbjct: 379 WMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYG 438
Query: 439 HAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVI 498
HAG G MYI+ G + + E C+DP ++ W A R H M T+ +KLYVI
Sbjct: 439 HAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVI 498
Query: 499 GGSN-NDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRG 557
GG++ DV YS T QW+ + + G + G+AV +N+IYV+GG S N
Sbjct: 499 GGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 558
Query: 558 SRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTL--PRSLLLEPPRGTPDRSQAD 612
V YD EKD W + L S+ G+ AC LT+ P P R +P + +D
Sbjct: 559 CMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSD 615
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 325 bits (834), Expect = 6e-89
Identities = 195/582 (33%), Positives = 300/582 (51%), Gaps = 20/582 (3%)
Query: 26 TYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKE 85
T+ + HS +LL+GL LR G L DVVL + AH+++LAA DYFR MF GG++E
Sbjct: 39 TFSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMRE 98
Query: 86 MEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMS 145
Q+ + + GVS + I+ F Y++E+ L L VQ+ L AA LQ+ ++ C +FL +
Sbjct: 99 ASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKA 158
Query: 146 WVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRL 205
+ E L++ ++A F L+ L E +D + ++F+ + + + +LPLE++ L SNRL
Sbjct: 159 AMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRL 218
Query: 206 EVSCETEVYEGAL--LYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVL----QRLHD 259
+ E +++ A+ L H + +A + H +RFPLM++ L Q L
Sbjct: 219 QSCAEIDLFRAAVRWLQHDPARRPRASHVLCH--------IRFPLMQSSELVDSVQTLDI 270
Query: 260 KLDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAK 319
++ R + A Y Q +QSP+T +RSD +V FGG T S
Sbjct: 271 MVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKV 330
Query: 320 YLNPLLGEWKHF--TASLAPRMSNQGIAVLNNFVYLIGGDN--NVQGFRAESRCWRYDPR 375
Y P G +HF + S+ +AVL+NFVY+ GG + G A C+RYDP
Sbjct: 331 YQLPEPGA-RHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPH 389
Query: 376 HNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKRE 435
NRW ++Q++Q+ + V+ +YA GR+ L +VERY P N W Y LKR
Sbjct: 390 LNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRR 449
Query: 436 VYAHAGATLEGKMYITCGRR-GEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNK 494
+ HAGA G++YI+ G + K HCYDP ++ W A R H M +
Sbjct: 450 TWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGR 509
Query: 495 LYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSH 554
+Y +GG + DV V Y + QW+SV P+ AG E G +L+ +IY++GG +
Sbjct: 510 IYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNW 569
Query: 555 NRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRS 596
+ TG V +Y+ + D WE S +G+A + LPR+
Sbjct: 570 RLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLPRA 611
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 311 bits (798), Expect = 9e-85
Identities = 198/585 (33%), Positives = 305/585 (52%), Gaps = 24/585 (4%)
Query: 24 NNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGL 83
+ YR A HS +L+ L R G+ DVVLV + + + AHR LLA DYF MF G+
Sbjct: 20 SKVYRWADHSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGM 79
Query: 84 KEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFL 143
+E Q+EV + G SY + ++ F+Y EL L N+ L A LQI ++ FCC++L
Sbjct: 80 REAFQKEVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYL 139
Query: 144 MSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQ-LPLEKVYSLLSS 202
V E+N L + LA ++ L RL +D +IL +F S T + Q + ++K+ LSS
Sbjct: 140 EQEVSEDNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSS 199
Query: 203 NRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLM-EAEVLQRLHDKL 261
+ ++ CE ++ + AL + + +A ++LE + FPL+ + ++L R+ +
Sbjct: 200 SEVQRECEHDLLQAALQWLTQQPEREA------HARQVLENIHFPLIPKNDLLHRVKPAV 253
Query: 262 -----DPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSD 316
+ + A+ YH N + QP +Q+ +T LR++ + ++ GG S LSD
Sbjct: 254 CSLLPKEANCEGFIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSD 313
Query: 317 QAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGG----DNNVQGFRAESRCWRY 372
YL+ +W T L R S+ +AVL F+++ GG DN G A + +RY
Sbjct: 314 DTCYLDAKSEQWVKET-PLPARRSHHCVAVLGGFIFIAGGSFSRDNG--GDAASNLLYRY 370
Query: 373 DPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPL 432
DPR +W ++ S+ Q D + + + A+ GR+ + L++VE Y P T+SW+YVA L
Sbjct: 371 DPRCKQWIKVASMNQRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGL 430
Query: 433 KREVYAHAGATLEGKMYITCGRRGE--DYLKETHCYDPGSNTWHTLADGPVRRAWHGMAT 490
R Y HAG + +YI+ G + Y K CYD ++ W R WH M +
Sbjct: 431 PRFTYGHAGTIYKDFVYISGGHDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCS 490
Query: 491 LLNKLYVIGGS--NNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYV 548
L + +Y IGGS N ++ R DV V YS QW+ V PL + E G+AV + RIY+
Sbjct: 491 LGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYI 550
Query: 549 LGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTL 593
LGG S + + V +YD E D W G L +I+G +ACV L
Sbjct: 551 LGGYSWENTAFSKTVQVYDREADKWSRGVDLPKAIAGGSACVCAL 595
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 269 bits (687), Expect = 7e-72
Identities = 167/588 (28%), Positives = 281/588 (47%), Gaps = 20/588 (3%)
Query: 22 CVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAG 81
C+++ A + LL GL +R L D+V+ + + + H+ ++A+ +YF +
Sbjct: 45 CISSELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILK- 103
Query: 82 GLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCD 141
K+ + V ++ +S + ++ + YT +L LSL + + AA LQI ++ C D
Sbjct: 104 --KDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSD 161
Query: 142 FLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLS 201
FL+ + EN + V +AE + L +I NF+ F+ +D++ +L E++ LL
Sbjct: 162 FLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAESDQFMKLTFEQINELLI 221
Query: 202 SNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVL----QRL 257
+ L++ E ++ A+ + ++ DQ + LL +RF + A+ L Q +
Sbjct: 222 DDDLQLPSEIVAFQIAMKW------LEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSV 275
Query: 258 HDKLDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQ 317
+ + + A+ YH Q +LQS +T +R + +V GG LS
Sbjct: 276 PRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRD 335
Query: 318 AKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGG----DNNVQGFRAESRCWRYD 373
Y +P G W T + + NQ +AV++ F+Y+ GG D Q A S RYD
Sbjct: 336 ILYRDPENG-WSKLT-EMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYD 393
Query: 374 PRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLK 433
PR N W + S+ Q+ S+ V +YA GR+ L ++E Y P+TN W PL+
Sbjct: 394 PRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLE 453
Query: 434 REVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLN 493
HA A +G++ +T G Y + YDP S++W L + R WH TL +
Sbjct: 454 VARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSD 513
Query: 494 KLYVIGGSN-NDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGR 552
++YV+GGS G R DV V CYS +GQWS PL G G++ L R Y++GG
Sbjct: 514 RVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGW 573
Query: 553 SHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLE 600
+ + + E + W E +L + G++ C L++P ++ E
Sbjct: 574 NEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTRE 621
>gi|226442729 kelch-like 15 [Homo sapiens]
Length = 604
Score = 265 bits (677), Expect = 1e-70
Identities = 186/609 (30%), Positives = 291/609 (47%), Gaps = 50/609 (8%)
Query: 29 SAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQ 88
S+ H ++ G AL + G+L DV LV+E +AH+ LLA DYFR MF ++E +Q
Sbjct: 10 SSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQ 69
Query: 89 EEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVD 148
+++ + G++ +L F+Y +ELS++ V E L AA +Q+ E++ FCC FL++ +
Sbjct: 70 DKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKIC 129
Query: 149 EENILDVYRLAELF--DLSRLTEQLDTYILKNFV-AFSRTDKYRQLPLEKVYSLLSSNRL 205
EN ++ RL + F ++ + E+LDT++L NFV SR D L EK+ S L ++ L
Sbjct: 130 LENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHL 189
Query: 206 EVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPS- 264
E E+YE + ++ D+ +++ +RF LM + +K+ S
Sbjct: 190 SRFPEIELYEAVQSW------LRHDRRRWRHTDTIIQNIRFCLMTP---TSVFEKVKTSE 240
Query: 265 ------PLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQA 318
LR V AL Y +N QP L + +RS F G+ S V S
Sbjct: 241 FYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIG-HSMVNSKIL 299
Query: 319 KYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDN-NVQG-FRAESRCWRYDPRH 376
P + W P + +A++NNFV+L+GG+ G F A S+ +RYDPR
Sbjct: 300 LLKKPRV--WWELEGPQVP-LRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQ 356
Query: 377 NRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREV 436
N W Q+ + ++ +V V+G++IYAVAGR + ERYD + W +V P
Sbjct: 357 NSWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNK 416
Query: 437 YAHAGATLEGKMYITCGRRGEDYLKETHCYDPG---------------SNTWHTLADGPV 481
Y H G L K++IT G K+ +DP +N W +
Sbjct: 417 YGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNY 476
Query: 482 RRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVAC-----YSCTSGQWSSVCPLPAGHGE 536
R +H M + KLYV GG R C Y+ + QW+ + +P G
Sbjct: 477 ARCFHKMISYNGKLYVFGGV--CVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSG 534
Query: 537 PGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEG--PQLDNSISGLAACVLTLP 594
G+ VLD +I VLGG +N G + + +D +++ W+E P++ + GL C L P
Sbjct: 535 HGVTVLDKQIMVLGGLCYN-GHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFP 593
Query: 595 RSLLLEPPR 603
+L E R
Sbjct: 594 DYVLDEVRR 602
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 249 bits (635), Expect = 7e-66
Identities = 180/597 (30%), Positives = 288/597 (48%), Gaps = 48/597 (8%)
Query: 29 SAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQ 88
S H+ ++L L R GIL D+ L+ E + AH+ +LAA DYFR MF+ + E
Sbjct: 21 SESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGA 80
Query: 89 EEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVD 148
+EV +HGV+ + Q L F YT ++ L +Q+ L A LQ+ E+++ C +L+ ++
Sbjct: 81 DEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELN 140
Query: 149 EENILDVYRLAELFDLSRLTEQLDTYILKNF--VAFSRTDKYRQLPLEKVYSLLSSNRLE 206
N LD+YRLA+LF+L+ L + + +++K+ + SR ++ LP + +L S+RL
Sbjct: 141 SFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDRLT 200
Query: 207 VSCETEVYEGALLY-----HYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRL---H 258
E ++++ A+ + HY +LL+ +RF LM+ + L + H
Sbjct: 201 SLSEEQIWQLAVRWLEHNCHYQYMD------------ELLQYIRFGLMDVDTLHTVALSH 248
Query: 259 DKLDPSPLRDT-VASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQ 317
+ S V AL YH++ QP Q+ +T+ R + GG V +
Sbjct: 249 PLVQASETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKV--KE 306
Query: 318 AKYLNPL---------LGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFR--AE 366
+Y NP+ + W A + S+ +AV+ +F+++ GG+ R A
Sbjct: 307 LRYFNPVDQENALIAAIANWSEL-APMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAV 365
Query: 367 SRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGR-DYHNDLNAVERYDPATNS 425
RYDPR N W +I ++ + + Y+YAV GR + L VERY P N
Sbjct: 366 RTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNK 425
Query: 426 WAYVAPLKREVYAHAGATLEGKMYITCG-RRGEDYLKETHCYDPGSNTWHTLADGPVRRA 484
W +V R + HAG +G ++I+ G Y Y+P N W + + RR
Sbjct: 426 WTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRV 485
Query: 485 WHGMATLLNKLYVIGGSNNDAGYRRD---VHQVACYSCTSGQWSSV-CPLPAGHGEPGIA 540
+H MA + KLYV+GG ND Y D V + Y+ + QW+ L G E G+A
Sbjct: 486 YHSMAAVQRKLYVLGG--NDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVA 543
Query: 541 VLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEE---GPQLDNSISGLAACVLTLP 594
V + RIY++GG S + + DV ++ EE GP L + +G+AAC L P
Sbjct: 544 VHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAP 600
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 247 bits (631), Expect = 2e-65
Identities = 171/563 (30%), Positives = 269/563 (47%), Gaps = 28/563 (4%)
Query: 20 PHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMF 79
P Y S +H + L + LR L DVVLVV + I AHR++L+A YFR MF
Sbjct: 38 PQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMF 97
Query: 80 AGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFC 139
G L E Q EV+I + AM ++ F YTS++ + NVQ L AAC LQ+ EI C
Sbjct: 98 TGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEAC 157
Query: 140 CDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSL 199
C+FL +D N L + A+ L D + NF ++++ LP ++ +
Sbjct: 158 CEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDI 217
Query: 200 LSSNRLEVSCETEVYEGALLY-HYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRL- 257
+SS+ L V E +V+ + + YS+++ + + P++L+ VR PL+ + L
Sbjct: 218 ISSDELNVRSEEQVFNAVMAWVKYSIQERRP------QLPQVLQHVRLPLLSPKFLVGTV 271
Query: 258 -HDKLDPS--PLRDTVASALMYHRNESLQPSLQSPQTELRSDFQC---VVGFGGIHSTPS 311
D L S RD V A Y +P +Q P+T R +C + GG S
Sbjct: 272 GSDPLIKSDEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCS--G 329
Query: 312 TVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWR 371
+S +Y +P EW+ AS++ R G++VL++ +Y +GG + G + R
Sbjct: 330 DAISSVERY-DPQTNEWR-MVASMSKRRCGVGVSVLDDLLYAVGGHD---GSSYLNSVER 384
Query: 372 YDPRHNRW-FQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVA 430
YDP+ N+W + + V V+G ++YAV G+D + LN VERYDP N W VA
Sbjct: 385 YDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVA 444
Query: 431 PLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMAT 490
+ A A L G +Y G G L Y+P N WHT+A RR G A
Sbjct: 445 SMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAV 504
Query: 491 LLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLG 550
+ +Y +GG ++ ++ Y+ + QWS V + + G+AV++ ++ +G
Sbjct: 505 YQDMIYAVGGRDDTT----ELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVG 560
Query: 551 GRSHNRGSRTGYVHIYDVEKDCW 573
G +T + ++D + + W
Sbjct: 561 GFDGTTYLKT--IEVFDPDANTW 581
Score = 90.5 bits (223), Expect = 4e-18
Identities = 52/170 (30%), Positives = 76/170 (44%), Gaps = 4/170 (2%)
Query: 322 NPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQ 381
+P +W AS++ R +AVL F+Y +GG + R Y+P+ NRW
Sbjct: 434 DPKENKWTR-VASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVER---YNPQENRWHT 489
Query: 382 IQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAG 441
I + L V IYAV GRD +L++ ERY+P TN W+ V +
Sbjct: 490 IAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGL 549
Query: 442 ATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATL 491
A + G++ G G YLK +DP +NTW RR G+ +
Sbjct: 550 AVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGVGVI 599
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 233 bits (593), Expect = 5e-61
Identities = 156/574 (27%), Positives = 270/574 (47%), Gaps = 20/574 (3%)
Query: 27 YRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEM 86
Y++ H++ R + + L DV+L+V R I AHR++L++ DYF MF + E
Sbjct: 189 YQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEA 248
Query: 87 EQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSW 146
+QEE+ + G+ NA+ ++ F YT LEL ++ L AAC LQ+P+++ CC FLM
Sbjct: 249 KQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKL 308
Query: 147 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLE 206
+ N L + A+ L + +Y ++N + R ++ LP E+++ LL+S+ +
Sbjct: 309 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVN 368
Query: 207 VSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKL---DP 263
V E ++ +++ Q + + +S+ LL +R PL+ ++L L + +
Sbjct: 369 VPDEETIFHALMMWVKYDMQSRCNDLSM-----LLAFIRLPLLPPQILADLENHALFKND 423
Query: 264 SPLRDTVASALMYHRNESLQPSLQSPQTELR-SDFQCVVGFGGIHSTPSTVLSDQAKYLN 322
+ + A+ YH + +QSP+T+ R S + GG+ + ++
Sbjct: 424 LECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRT 483
Query: 323 PLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQI 382
L W + R G+AV+++ +++IGG + G + + Y+P+ W +
Sbjct: 484 NL---WIQ-AGMMNGRRLQFGVAVIDDKLFVIGGRD---GLKTLNTVECYNPKTKTWTVL 536
Query: 383 QSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGA 442
+ L V V+ IYAV G D + LN VER+DP + W +VA + A
Sbjct: 537 PPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVA 596
Query: 443 TLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSN 502
L GK+Y GR G L YDP +N W+ A RR G+AT LY +GG +
Sbjct: 597 ALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHD 656
Query: 503 NDAGYR--RDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRT 560
A R + V Y + W+ V PL G+ +L +R+Y +GG ++ +
Sbjct: 657 APASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG--YDGQTYL 714
Query: 561 GYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLP 594
+ YD + + W + L+ +G V+ P
Sbjct: 715 NTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 231 bits (589), Expect = 2e-60
Identities = 157/552 (28%), Positives = 260/552 (47%), Gaps = 24/552 (4%)
Query: 49 LFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFI 108
L DV+LV R I AHR++L++ DYF MF ++E QEE+ + GV N++ ++ +
Sbjct: 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYA 232
Query: 109 YTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLT 168
YT LEL N++ L AC LQ+ +++ CC FLM + N L + A+ + L
Sbjct: 233 YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLH 292
Query: 169 EQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY-HYSLEQV 227
+ Y +++F+ R ++ LP ++ LL+S+ + + E + L + + LEQ
Sbjct: 293 KVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQR 352
Query: 228 QADQISLHEPPKLLETVRFPLMEAEVLQRLHDKL---DPSPLRDTVASALMYHRNESLQP 284
+ D KLL +R PL+ + L + + + D + + A+ YH +P
Sbjct: 353 RKDL------SKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRP 406
Query: 285 SLQSPQTELR-SDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQG 343
LQSP+T+ R S + GG+ ST ++ + W A++ R G
Sbjct: 407 MLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNM---WTP-VANMNGRRLQFG 462
Query: 344 IAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYA 403
+AVL++ +Y++GG + G + + Y+P+ W + + L V V+ +YA
Sbjct: 463 VAVLDDKLYVVGGRD---GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYA 519
Query: 404 VAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKET 463
V G D + LN VER+DP W +VA + A L GK+Y GR G LK
Sbjct: 520 VGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSV 579
Query: 464 HCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAG--YRRDVHQVACYSCTS 521
C+DP +N W A RR G+ T LY IGG + A R V Y +
Sbjct: 580 ECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 639
Query: 522 GQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDN 581
W++V + G+ +L +++Y +GG ++ + V YD + + W + L
Sbjct: 640 DMWTAVASMSISRDAVGVCLLGDKLYAVGG--YDGQAYLNTVEAYDPQTNEWTQVAPL-- 695
Query: 582 SISGLAACVLTL 593
+ ACV+T+
Sbjct: 696 CLGRAGACVVTV 707
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 231 bits (589), Expect = 2e-60
Identities = 157/552 (28%), Positives = 260/552 (47%), Gaps = 24/552 (4%)
Query: 49 LFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFI 108
L DV+LV R I AHR++L++ DYF MF ++E QEE+ + GV N++ ++ +
Sbjct: 219 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYA 278
Query: 109 YTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLT 168
YT LEL N++ L AC LQ+ +++ CC FLM + N L + A+ + L
Sbjct: 279 YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLH 338
Query: 169 EQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY-HYSLEQV 227
+ Y +++F+ R ++ LP ++ LL+S+ + + E + L + + LEQ
Sbjct: 339 KVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQR 398
Query: 228 QADQISLHEPPKLLETVRFPLMEAEVLQRLHDKL---DPSPLRDTVASALMYHRNESLQP 284
+ D KLL +R PL+ + L + + + D + + A+ YH +P
Sbjct: 399 RKDL------SKLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRP 452
Query: 285 SLQSPQTELR-SDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQG 343
LQSP+T+ R S + GG+ ST ++ + W A++ R G
Sbjct: 453 MLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNM---WTP-VANMNGRRLQFG 508
Query: 344 IAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYA 403
+AVL++ +Y++GG + G + + Y+P+ W + + L V V+ +YA
Sbjct: 509 VAVLDDKLYVVGGRD---GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYA 565
Query: 404 VAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKET 463
V G D + LN VER+DP W +VA + A L GK+Y GR G LK
Sbjct: 566 VGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSV 625
Query: 464 HCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAG--YRRDVHQVACYSCTS 521
C+DP +N W A RR G+ T LY IGG + A R V Y +
Sbjct: 626 ECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 685
Query: 522 GQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDN 581
W++V + G+ +L +++Y +GG ++ + V YD + + W + L
Sbjct: 686 DMWTAVASMSISRDAVGVCLLGDKLYAVGG--YDGQAYLNTVEAYDPQTNEWTQVAPL-- 741
Query: 582 SISGLAACVLTL 593
+ ACV+T+
Sbjct: 742 CLGRAGACVVTV 753
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 229 bits (583), Expect = 8e-60
Identities = 169/597 (28%), Positives = 268/597 (44%), Gaps = 43/597 (7%)
Query: 27 YRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEM 86
+ S +H + +R G+L D+VL V + I AH+++LA+ YF MF + E
Sbjct: 69 HNSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSES 128
Query: 87 EQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSW 146
Q V +H + A+ Q++ F YT+E+ + NVQ L AA LQ+ + CC FL+S
Sbjct: 129 RQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188
Query: 147 VDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLE 206
+D N L + A+ S L + Y+L++FV ++T+++ LPL++V L+SS+ L
Sbjct: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248
Query: 207 VSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLM---------EAEVLQRL 257
V E EVY L S + D H P+L++ VR PL+ +AE L R
Sbjct: 249 VPSEEEVYRAVL----SWVKHDVDARRQH-VPRLMKCVRLPLLSRDFLLGHVDAESLVRH 303
Query: 258 HDKLDPSPLRDTVASALMYHRNESLQPSLQSPQTELR-----SDFQCVVGFGGIHSTPST 312
H +D + AL +H + L + +T R VG G + +
Sbjct: 304 H-----PDCKDLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFA---- 354
Query: 313 VLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRY 372
+ + + W H AS++ R + G+A + N +Y +GG + Y
Sbjct: 355 -IHGDCEAYDTRTDRW-HVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVE---SY 409
Query: 373 DPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPL 432
DP N W S+ + L V + +Y+ G D + LN+ ERYDP T +W VA +
Sbjct: 410 DPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAM 469
Query: 433 KREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLL 492
ATL+G +Y G +L Y+P N W +A RR+ G+A L
Sbjct: 470 STRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLE 529
Query: 493 NKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGR 552
LYV GG++ + ++ V YS +G W SV P+ + +D +Y +GG
Sbjct: 530 GALYVAGGNDGTS----CLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGG- 584
Query: 553 SHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTLPRSLLLEPPRGTPDRS 609
++ S + Y+ + W + S + VL LL PP +P S
Sbjct: 585 -NDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVL----ELLNFPPPSSPTLS 636
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 229 bits (583), Expect = 8e-60
Identities = 166/622 (26%), Positives = 289/622 (46%), Gaps = 74/622 (11%)
Query: 32 HSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFA----------- 80
HS LL GL L + DV L +G+ H+ +LA+ YFR +F+
Sbjct: 15 HSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSSHPPLGGGVGG 74
Query: 81 ----GGLKEMEQ------------------------------------EEVLIHGVSYNA 100
G K+ +Q +++ G S
Sbjct: 75 QDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCSSIG 134
Query: 101 MCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAE 160
+ +L ++YT+ + LSL V+E L + L IP++ C FL + +N V ++A
Sbjct: 135 LRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCKIAA 194
Query: 161 LFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY 220
L L + + Y++++ + L E++ +LL S V E +++ ++L+
Sbjct: 195 LHGLEETKKLANKYLVEDVLL---------LNFEEMRALLDSLPPPVESELALFQMSVLW 245
Query: 221 HYSLEQVQADQISLHEPPKLLETVRFPLMEA-EVLQRLH--DKLDPSPL-RDTVASALMY 276
LE + + + P L++ +RF L+ A E+++R+ D + P+ + + A+ Y
Sbjct: 246 ---LEHDR--ETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNY 300
Query: 277 HRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLA 336
H Q QS + +RS+ + ++ GG+ P + S+ +Y + WK T +
Sbjct: 301 HLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTI-MP 359
Query: 337 PRMSNQGIAVLNNFVYLIGGDN--NVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSV 394
++ + + NF++++GG++ N G + + RYDPR N W Q+ +Q+ A
Sbjct: 360 YNSAHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYA 419
Query: 395 CVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGR 454
C + +++Y + GR+ L++VE Y+ TN W YV+ L + + AHAGA GK+YI+ G
Sbjct: 420 CRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGV 479
Query: 455 RGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQV 514
+Y+ +CYDP + W D +RA H +A + ++LY IGG++ DV V
Sbjct: 480 HNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLV 539
Query: 515 ACYSCTSGQWSSV-CPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCW 573
CY QW+ + P+ G PG AVLD+ IY++GG S + G+ Y EK W
Sbjct: 540 ECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTW 599
Query: 574 EE-GPQLDNSISGLAACVLTLP 594
E + ++G A + LP
Sbjct: 600 TELEGDVAEPLAGPACVTVILP 621
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 226 bits (576), Expect = 5e-59
Identities = 158/542 (29%), Positives = 256/542 (47%), Gaps = 32/542 (5%)
Query: 43 LRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMC 102
+R G L DV L + AHRI+LAAS YF MF + E +Q+E+++ G+ +A+
Sbjct: 31 IRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPSALE 90
Query: 103 QILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELF 162
+++F Y L + NVQ L+ A LQ+ I CC FL + +N L V + AE
Sbjct: 91 ALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFAETM 150
Query: 163 DLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY-H 221
+ L + +++I ++FV S ++++ LPLE V L+S + L V E +V+E AL +
Sbjct: 151 MCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALAWVR 210
Query: 222 YSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPSPL-------RDTVASAL 274
Y EQ + + P+LL +R PL Q L D++ L RD V A
Sbjct: 211 YDREQ-RGPYL-----PELLSNIRLPLCRP---QFLSDRVQQDDLVRCCHKCRDLVDEAK 261
Query: 275 MYHRNESLQPSLQSPQTELR---SDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHF 331
YH +P L + +T R S + GG++S ++ + + +P+ W+
Sbjct: 262 DYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSL--NVVEVFDPIANCWERC 319
Query: 332 TASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHAD 391
R S G+AV+N +Y IGG G S Y+P + W ++ S+ + +
Sbjct: 320 RPMTTAR-SRVGVAVVNGLLYAIGG---YDGQLRLSTVEAYNPETDTWTRVGSMNSKRSA 375
Query: 392 LSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYIT 451
+ V+ IY G D ++ L++VE Y P T+ W V + A EG++Y++
Sbjct: 376 MGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVS 435
Query: 452 CGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDV 511
G G Y+ + TWH A +R HG A+L +K++V GG + +G+ +
Sbjct: 436 GGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG-SGF---L 491
Query: 512 HQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKD 571
YS + QW + P+ + R+Y +GG ++ S V +YD E D
Sbjct: 492 SIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGG--YDGQSNLSSVEMYDPETD 549
Query: 572 CW 573
CW
Sbjct: 550 CW 551
Score = 47.8 bits (112), Expect = 3e-05
Identities = 28/103 (27%), Positives = 52/103 (50%), Gaps = 3/103 (2%)
Query: 330 HFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEH 389
H A + + G A L + +++ GG + GF + + Y ++W I +
Sbjct: 458 HPAAGMLNKRCRHGAASLGSKMFVCGGYDG-SGFLSIAEM--YSSVADQWCLIVPMHTRR 514
Query: 390 ADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPL 432
+ +S+ +YAV G D ++L++VE YDP T+ W ++AP+
Sbjct: 515 SRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPM 557
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 216 bits (549), Expect = 7e-56
Identities = 148/536 (27%), Positives = 250/536 (46%), Gaps = 24/536 (4%)
Query: 65 RILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETL 124
R++L++ DYF MF ++E QEE+ + GV N++ ++ + YT LEL N++ L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 125 VAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSR 184
AC LQ+ +++ CC FLM + N L + A+ + L + Y +++F+ R
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 185 TDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY-HYSLEQVQADQISLHEPPKLLET 243
++ LP ++ LL+S+ + + E + L + + LEQ + D KLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDL------SKLLAY 347
Query: 244 VRFPLMEAEVLQRLHDKL---DPSPLRDTVASALMYHRNESLQPSLQSPQTELR-SDFQC 299
+R PL+ + L + + + D + + A+ YH +P LQSP+T+ R S
Sbjct: 348 IRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGT 407
Query: 300 VVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNN 359
+ GG+ ST ++ + W A++ R G+AVL++ +Y++GG +
Sbjct: 408 LFAVGGMDSTKGATSIEKYDLRTNM---WTP-VANMNGRRLQFGVAVLDDKLYVVGGRD- 462
Query: 360 VQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERY 419
G + + Y+P+ W + + L V V+ +YAV G D + LN VER+
Sbjct: 463 --GLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERW 520
Query: 420 DPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADG 479
DP W +VA + A L GK+Y GR G LK C+DP +N W A
Sbjct: 521 DPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQM 580
Query: 480 PVRRAWHGMATLLNKLYVIGGSNNDAG--YRRDVHQVACYSCTSGQWSSVCPLPAGHGEP 537
RR G+ T LY IGG + A R V Y + W++V +
Sbjct: 581 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAV 640
Query: 538 GIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTL 593
G+ +L +++Y +GG ++ + V YD + + W + L + ACV+T+
Sbjct: 641 GVCLLGDKLYAVGG--YDGQAYLNTVEAYDPQTNEWTQVAPL--CLGRAGACVVTV 692
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 213 bits (542), Expect = 4e-55
Identities = 157/541 (29%), Positives = 251/541 (46%), Gaps = 50/541 (9%)
Query: 33 SQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVL 92
S L GL LR L DV+L V+ + HR++LAA+ +YFR MF LKE ++ ++
Sbjct: 55 SLILQNGLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRII 114
Query: 93 IHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENI 152
I GV M +L + YTS+ ++ NVQ L AA Q ++ C FL ++ EN
Sbjct: 115 IKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENC 174
Query: 153 LDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETE 212
+ + RLA+ L L +Q+ +YI++NFV ++++ LP++ ++ +L S+ L V+ E +
Sbjct: 175 VGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQ 234
Query: 213 VYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLM---------EAEVLQRLHDKLDP 263
V+E + + + ++++ L P +LE VR PL+ EA+ L R ++ P
Sbjct: 235 VFETVMSW---VRHKPSERLCL--LPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFP 289
Query: 264 SPLRDTVASALMYH--RNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYL 321
+ A MYH NE + + E +S+ ++G T + L
Sbjct: 290 -----LLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIG----GCTKDERFVAEVTCL 340
Query: 322 NPL---------LGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRY 372
+PL L +H S + L N VY+ GG + W+Y
Sbjct: 341 DPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGK------ETQHDVWKY 394
Query: 373 DPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPL 432
+ N+W QI+ L + V+G +Y + G D +N VE YDP N W+ APL
Sbjct: 395 NSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPL 454
Query: 433 KREVYAHAGATLEGKMY-ITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATL 491
V + A + + K+Y I G G+ +T CYDP +N W A PV +
Sbjct: 455 LVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSF 514
Query: 492 LNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGG 551
+++YV+GG+ + + YS W V L GIA +NR+Y+ GG
Sbjct: 515 RDRIYVVGGA---------MRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGG 565
Query: 552 R 552
R
Sbjct: 566 R 566
Score = 46.6 bits (109), Expect = 7e-05
Identities = 38/144 (26%), Positives = 59/144 (40%), Gaps = 19/144 (13%)
Query: 455 RGEDYLKETHCYDPGSNTWHTLADGPV--------RRAWHGMA--TLLNKLYVIGGSNND 504
+ E ++ E C DP + +A P+ + W A TL N++Y+ GG
Sbjct: 329 KDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQ 388
Query: 505 AGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVH 564
H V Y+ + +W + L G + VL ++YV+GG + R V
Sbjct: 389 -------HDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGG--FDGLQRINNVE 439
Query: 565 IYDVEKDCWEEGPQLDNSISGLAA 588
YD +CW E L +S AA
Sbjct: 440 TYDPFHNCWSEAAPLLVHVSSFAA 463
Score = 37.4 bits (85), Expect = 0.043
Identities = 28/131 (21%), Positives = 48/131 (36%), Gaps = 10/131 (7%)
Query: 315 SDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDP 374
+D+ + +P +W A++ + +Y++GG A + Y P
Sbjct: 483 TDKTQCYDPSTNKWS-LKAAMPVEAKCINAVSFRDRIYVVGG--------AMRALYAYSP 533
Query: 375 RHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNA-VERYDPATNSWAYVAPLK 433
+ W + L E A + +Y GRD N++ A V +DP L
Sbjct: 534 LEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLP 593
Query: 434 REVYAHAGATL 444
R V H T+
Sbjct: 594 RGVSHHGSVTI 604
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 212 bits (540), Expect = 7e-55
Identities = 155/570 (27%), Positives = 261/570 (45%), Gaps = 28/570 (4%)
Query: 20 PHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMF 79
P ++ + S +H+Q +L + +R+ DV L V +AHR++LAAS YF +F
Sbjct: 7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALF 66
Query: 80 AGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFC 139
GG+KE ++ V I G+ +L FIYT + + ++NVQE ++AA LQ+ E++H C
Sbjct: 67 TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126
Query: 140 CDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSL 199
C+FL +D N + +++ +E L E + YI +F+ +++ L +++ +
Sbjct: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186
Query: 200 LSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHD 259
L S L + E +V+ A+ + L+ + + + E +L+ +RFPL+ + L + +
Sbjct: 187 LRSEELSIEDEYQVFLAAM--QWILKDLGKRRKHVVE---VLDPIRFPLLPPQRLLKYIE 241
Query: 260 KLDPSPLRDTVASALMYHRN-----------ESLQPSLQSPQTELRSDFQCVVGFGGIHS 308
+ LR + + L + LQ S P+ + R V G+ +
Sbjct: 242 GVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQG 301
Query: 309 ---TPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRA 365
+ S LS ++ ++ +SL S G+ VL VY IGG+ + F
Sbjct: 302 GRWSDSRALSCVERF--DTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDC 359
Query: 366 ESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNS 425
+ C YDP +W + S+ L VCV IYA+ G N +ER+DP N
Sbjct: 360 -TEC--YDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENK 416
Query: 426 WAYVAPLKREVYAHAGATLEGKMYITCGRRGEDY-LKETHCYDPGSNTWHTLADGPVRRA 484
W V + Y ++G +Y+ G E L+ YDP S W L RRA
Sbjct: 417 WEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRA 476
Query: 485 WHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDN 544
+ G+A L + +Y +GG N + +H V YS +W V + + ++
Sbjct: 477 YLGVAALNDCIYSVGGWNET---QDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
Query: 545 RIYVLGGRSHNRGSRTGYVHIYDVEKDCWE 574
+YV GGRS + H Y+V + WE
Sbjct: 534 LLYVSGGRSSSHDFLAPDTHRYEVFRLKWE 563
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 211 bits (536), Expect = 2e-54
Identities = 155/575 (26%), Positives = 261/575 (45%), Gaps = 32/575 (5%)
Query: 20 PHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMF 79
P ++ + S +H+Q +L + +R+ DV L V +AHR++LAAS YF +F
Sbjct: 7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALF 66
Query: 80 AGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFC 139
GG+KE ++ V I G+ +L FIYT + + ++NVQE ++AA LQ+ E++H C
Sbjct: 67 TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126
Query: 140 CDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSL 199
C+FL +D N + +++ +E L E + YI +F+ +++ L +++ +
Sbjct: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186
Query: 200 LSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHD 259
L S L + E +V+ A+ + L+ + + + E +L+ +RFPL+ + L + +
Sbjct: 187 LRSEELSIEDEYQVFLAAM--QWILKDLGKRRKHVVE---VLDPIRFPLLPPQRLLKYIE 241
Query: 260 KLDPSPLRDTVASALMYHRN-----------ESLQPSLQSPQTELRSDFQCVVGFGGIHS 308
+ LR + + L + LQ S P+ + R V G+ +
Sbjct: 242 GVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQG 301
Query: 309 ---TPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRA 365
+ S LS ++ ++ +SL S G+ VL VY IGG+ + F
Sbjct: 302 GRWSDSRALSCVERF--DTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDC 359
Query: 366 ESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNS 425
+ C YDP +W + S+ L VCV IYA+ G N +ER+DP N
Sbjct: 360 -TEC--YDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENK 416
Query: 426 WAYVAPLKREVYAHAGATLEGKMYITCGRRGEDY-LKETHCYDPGSNTWHTLADGPVRRA 484
W V + Y ++G +Y+ G E L+ YDP S W L RRA
Sbjct: 417 WEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRA 476
Query: 485 WHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDN 544
+ G+A L + +Y +GG N + +H V YS +W V + + ++
Sbjct: 477 YLGVAALNDCIYSVGGWNET---QDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
Query: 545 RIYVLGGRSHNRG----SRTGYVHIYDVEKDCWEE 575
+YV GGRS + V +Y+ D W E
Sbjct: 534 LLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTE 568
Score = 57.0 bits (136), Expect = 5e-08
Identities = 44/156 (28%), Positives = 67/156 (42%), Gaps = 9/156 (5%)
Query: 343 GIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIY 402
G + +Y+IGG +N +G S YDP RW + + A L V + IY
Sbjct: 431 GCCEMQGLIYVIGGISN-EGIELRS-FEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIY 488
Query: 403 AVAGRDYHND-LNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGE-DYL 460
+V G + D L+ VE+Y W VA +K + G +Y++ GR D+L
Sbjct: 489 SVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFL 548
Query: 461 K-----ETHCYDPGSNTWHTLADGPVRRAWHGMATL 491
Y+P S+TW + + R G+A L
Sbjct: 549 APGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 211 bits (536), Expect = 2e-54
Identities = 165/606 (27%), Positives = 268/606 (44%), Gaps = 29/606 (4%)
Query: 1 MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQ-----HSQALLRGLLALRDSGILFDVVLV 55
MA++ +L Q H +N T Q H++ LR + L DV+L+
Sbjct: 130 MADDNIEDSTARLDTQ--HSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLI 187
Query: 56 VEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELEL 115
I AHR++L+A DYF MF + E +QEEV + GV NA+ ++ + YT L+L
Sbjct: 188 AGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQL 247
Query: 116 SLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYI 175
++ L AAC LQ+ ++I C +FL+ + N L + + + L Y
Sbjct: 248 KEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYT 307
Query: 176 LKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQAD-QISL 234
+++F+ + ++ LP ++ LL S+ + V E + +H ++ V D Q
Sbjct: 308 MEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETI------FHALMQWVGHDVQNRQ 361
Query: 235 HEPPKLLETVRFPLMEAEVLQRLHDK---LDPSPLRDTVASALMYHRNESLQPSLQSPQT 291
E LL +R PL+ ++L L + + A+ YH + +QSP+T
Sbjct: 362 GELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRT 421
Query: 292 ELR-SDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNF 350
+ R S + GG+ + T + KY + W H ++ R G+AV++N
Sbjct: 422 KPRKSTVGALYAVGGMDAMKGTTTIE--KY-DLRTNSWLHI-GTMNGRRLQFGVAVIDNK 477
Query: 351 VYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYH 410
+Y++GG + G + + ++P W + + L V + +YAV G D
Sbjct: 478 LYVVGGRD---GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGW 534
Query: 411 NDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGS 470
+ LN VER+DP W YVA + L K+Y GR G LK +DP +
Sbjct: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHT 594
Query: 471 NTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYR--RDVHQVACYSCTSGQWSSVC 528
N W A RR G+AT LYV+GG + A R V Y WS+V
Sbjct: 595 NKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA 654
Query: 529 PLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAA 588
PL + L +++YV+GG + T V YD +++ W+E ++ +G
Sbjct: 655 PLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNT--VESYDAQRNEWKEEVPVNIGRAGACV 712
Query: 589 CVLTLP 594
V+ LP
Sbjct: 713 VVVKLP 718
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 210 bits (535), Expect = 3e-54
Identities = 155/558 (27%), Positives = 256/558 (45%), Gaps = 26/558 (4%)
Query: 43 LRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMC 102
LR G L DVV+ V G AH+ +L + YFR +F G E++ I G+S + M
Sbjct: 32 LRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMK 91
Query: 103 QILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELF 162
I+ + YT + ++ NV++ L AA Q I I+ CC+FL S + +N + + + + +
Sbjct: 92 LIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYY 151
Query: 163 DLSRLTEQLDTYILKNFVAFSRTD-KYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYH 221
L ++ +IL NF + ++ +L + ++ ++ + L V E V+E L +
Sbjct: 152 YCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWI 211
Query: 222 YSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQ---RLHDKL-DPSPLRDTVASAL--M 275
Q + IS+ LL VR LM AE +++D + D + + +AL M
Sbjct: 212 SHDPQNRKQHISI-----LLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAM 266
Query: 276 Y--HRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTA 333
Y + N +P T R + + GG T + + + W + T
Sbjct: 267 YDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPT---NAIEAYDARADRWVNVTC 323
Query: 334 SLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLS 393
+ G A L +VY+IGG ++V F + R +DP W Q+ + +S
Sbjct: 324 EEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKR---FDPVKKTWHQVAPMHSRRCYVS 380
Query: 394 VCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCG 453
V V+G +IYA+ G D + LN ERY+P TN W +AP+ + + TL GK+YI G
Sbjct: 381 VTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGG 440
Query: 454 RRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQ 513
G + L Y+ SN W +A RR+ G+ +Y +GG + G R +
Sbjct: 441 FNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFD---GANR-LRS 496
Query: 514 VACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCW 573
YS + W ++ + GI V+D+ ++V+GG N + T V YD + D W
Sbjct: 497 AEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG--FNGFTTTFNVECYDEKTDEW 554
Query: 574 EEGPQLDNSISGLAACVL 591
+ + S L+ CV+
Sbjct: 555 YDAHDMSIYRSALSCCVV 572
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 209 bits (531), Expect = 8e-54
Identities = 163/559 (29%), Positives = 252/559 (45%), Gaps = 39/559 (6%)
Query: 32 HSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEV 91
HS+ LL+GL LR L D++L V I AH+++LA+ YF+ MF G L E E EV
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 92 LIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 151
+ A+ I+ + YT + +S V+ L AA LQI ++ CC FL S +D N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 152 ILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCET 211
+ + R AE + L YI +NF A +T+++ +L + ++S++ L V+ E
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 212 EVYEGALLYHYSLE-----QVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDK----LD 262
V+ Y+LE VQ Q L +LL +VR PL+ + L RL++ D
Sbjct: 197 TVF-------YALESWIKYDVQERQKYL---AQLLNSVRLPLLSVKFLTRLYEANHLIRD 246
Query: 263 PSPLRDTVASALMYHRNESLQPSLQSP-QTELRSDFQCVVGFGGIHSTPSTVLSDQAKYL 321
+ + AL YH + S Q+ T R + + GG + D +
Sbjct: 247 DRTCKHLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGG--KSGLFACLDSVEMY 304
Query: 322 NPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGG-------DNNVQGFRAESRCWRYDP 374
P W PR GI VL+ VY+IGG ++ CW +P
Sbjct: 305 FPQNDSWIGLAPLNIPRY-EFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECW--NP 361
Query: 375 RHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKR 434
N W ++ + + + L V V+ +YA+ G D + L +VE+Y P W VAP+
Sbjct: 362 DTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTT 421
Query: 435 EVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNK 494
A A L+G +Y G G ++ YDP ++W +A +R G+ +L
Sbjct: 422 TRSCFAAAVLDGMIY-AIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGF 480
Query: 495 LYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSH 554
++V+GG N + + + Y QW+ P+ G AV+DN +YV+GG H
Sbjct: 481 IFVVGGHNGVS----HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGG--H 534
Query: 555 NRGSRTGYVHIYDVEKDCW 573
+ S V YD D W
Sbjct: 535 SGSSYLNTVQKYDPISDTW 553
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 208 bits (529), Expect = 1e-53
Identities = 150/552 (27%), Positives = 259/552 (46%), Gaps = 29/552 (5%)
Query: 32 HSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEV 91
H + + + LR +L DV +V E I AHR++LAA YF MF G + E + V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 92 LIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 151
I V + ++ ++YT+E++++ NVQ L AA LQ+ ++ CC+FL S + N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 152 ILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCET 211
L + A++ + L + +TY ++F ++++ L +E+V SL+SS++L +S E
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 212 EVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVL-QRLHDKL---DPSPLR 267
+V+E + + + V+ + ++ +L+E VR PL+ E L QR+ ++ + S +
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMA-----RLMEHVRLPLLPREYLVQRVEEEALVKNSSACK 276
Query: 268 DTVASALMYHRNESLQPSL-QSPQTELRSDF---QCVVGFGGIHSTPSTVLSDQAKYLNP 323
D + A+ YH + Q L +S +T LR+ + +V GG P + S +
Sbjct: 277 DYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECYDFKE 334
Query: 324 LLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQ 383
E H A L R G+ + V+ +GG N R YDP ++W +
Sbjct: 335 ---ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVD---SYDPVKDQWTSVA 388
Query: 384 SLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGAT 443
+++ + L V+ +YAV G D L++VE Y+ +N W +VAP+ +
Sbjct: 389 NMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGV 448
Query: 444 LEGKMYITCGRRG--EDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGS 501
+ G +Y G G L CY+ +N W +A+ RR+ G+ L N LY +GG
Sbjct: 449 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 508
Query: 502 NNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTG 561
+ + V Y T+ W V + G+ ++ +YV+GG +
Sbjct: 509 DGPLVRK----SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLA 562
Query: 562 YVHIYDVEKDCW 573
V Y+ D W
Sbjct: 563 SVEYYNPTTDKW 574
Score = 71.2 bits (173), Expect = 3e-12
Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 5/144 (3%)
Query: 304 GGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGF 363
GG LS Y N EW + A ++ R S G+ VLNN +Y +GG + G
Sbjct: 457 GGYDGASRQCLSTVECY-NATTNEWTYI-AEMSTRRSGAGVGVLNNLLYAVGGHD---GP 511
Query: 364 RAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPAT 423
YDP N W Q+ + + VC V +Y V G D +L +VE Y+P T
Sbjct: 512 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTT 571
Query: 424 NSWAYVAPLKREVYAHAGATLEGK 447
+ W V+ ++AG T+ K
Sbjct: 572 DKWTVVSSCMSTGRSYAGVTVIDK 595
Score = 64.7 bits (156), Expect = 2e-10
Identities = 46/191 (24%), Positives = 73/191 (38%), Gaps = 4/191 (2%)
Query: 401 IYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYL 460
+ V G + +VE YD W VA L + G ++ G G +
Sbjct: 312 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRV 371
Query: 461 KETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCT 520
+ YDP + W ++A+ RR+ G A L LY +GG + G + V Y+
Sbjct: 372 RTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG----LSSVEAYNIK 427
Query: 521 SGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLD 580
S +W V P+ G+ V+ +Y +GG V Y+ + W ++
Sbjct: 428 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 487
Query: 581 NSISGLAACVL 591
SG VL
Sbjct: 488 TRRSGAGVGVL 498
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 208 bits (529), Expect = 1e-53
Identities = 150/552 (27%), Positives = 259/552 (46%), Gaps = 29/552 (5%)
Query: 32 HSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEV 91
H + + + LR +L DV +V E I AHR++LAA YF MF G + E + V
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 92 LIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 151
I V + ++ ++YT+E++++ NVQ L AA LQ+ ++ CC+FL S + N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 152 ILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCET 211
L + A++ + L + +TY ++F ++++ L +E+V SL+SS++L +S E
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 212 EVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVL-QRLHDKL---DPSPLR 267
+V+E + + + V+ + ++ +L+E VR PL+ E L QR+ ++ + S +
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMA-----RLMEHVRLPLLPREYLVQRVEEEALVKNSSACK 272
Query: 268 DTVASALMYHRNESLQPSL-QSPQTELRSDF---QCVVGFGGIHSTPSTVLSDQAKYLNP 323
D + A+ YH + Q L +S +T LR+ + +V GG P + S +
Sbjct: 273 DYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECYDFKE 330
Query: 324 LLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQ 383
E H A L R G+ + V+ +GG N R YDP ++W +
Sbjct: 331 ---ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVD---SYDPVKDQWTSVA 384
Query: 384 SLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGAT 443
+++ + L V+ +YAV G D L++VE Y+ +N W +VAP+ +
Sbjct: 385 NMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGV 444
Query: 444 LEGKMYITCGRRG--EDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGS 501
+ G +Y G G L CY+ +N W +A+ RR+ G+ L N LY +GG
Sbjct: 445 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 504
Query: 502 NNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTG 561
+ + V Y T+ W V + G+ ++ +YV+GG +
Sbjct: 505 DGPLVRK----SVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLA 558
Query: 562 YVHIYDVEKDCW 573
V Y+ D W
Sbjct: 559 SVEYYNPTTDKW 570
Score = 71.2 bits (173), Expect = 3e-12
Identities = 45/144 (31%), Positives = 64/144 (44%), Gaps = 5/144 (3%)
Query: 304 GGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGF 363
GG LS Y N EW + A ++ R S G+ VLNN +Y +GG + G
Sbjct: 453 GGYDGASRQCLSTVECY-NATTNEWTYI-AEMSTRRSGAGVGVLNNLLYAVGGHD---GP 507
Query: 364 RAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPAT 423
YDP N W Q+ + + VC V +Y V G D +L +VE Y+P T
Sbjct: 508 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTT 567
Query: 424 NSWAYVAPLKREVYAHAGATLEGK 447
+ W V+ ++AG T+ K
Sbjct: 568 DKWTVVSSCMSTGRSYAGVTVIDK 591
Score = 64.7 bits (156), Expect = 2e-10
Identities = 46/191 (24%), Positives = 73/191 (38%), Gaps = 4/191 (2%)
Query: 401 IYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYL 460
+ V G + +VE YD W VA L + G ++ G G +
Sbjct: 308 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRV 367
Query: 461 KETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCT 520
+ YDP + W ++A+ RR+ G A L LY +GG + G + V Y+
Sbjct: 368 RTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG----LSSVEAYNIK 423
Query: 521 SGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLD 580
S +W V P+ G+ V+ +Y +GG V Y+ + W ++
Sbjct: 424 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 483
Query: 581 NSISGLAACVL 591
SG VL
Sbjct: 484 TRRSGAGVGVL 494
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 208 bits (529), Expect = 1e-53
Identities = 154/542 (28%), Positives = 252/542 (46%), Gaps = 31/542 (5%)
Query: 43 LRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMC 102
LR +L DV++V E IEAHR++LAA YF MF G + E + +++ I V +
Sbjct: 43 LRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLS 102
Query: 103 QILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELF 162
+++ +IYT+E+E++ NVQ L AA LQ+ ++ CCDFL S + N L + A++
Sbjct: 103 KLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVH 162
Query: 163 DLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY-H 221
+ L +Q + Y ++F +++ L L++V SL+SS++L VS E +V+E + + +
Sbjct: 163 TCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIN 222
Query: 222 YSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDK----LDPSPLRDTVASALMYH 277
Y E L KL+E VR PL+ + L + ++ + + +D + A+ YH
Sbjct: 223 YEKE------TRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 276
Query: 278 RNESLQPSL-QSPQTELRSDF---QCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTA 333
Q L ++P+T+ R+ + ++ GG P + S + W A
Sbjct: 277 LLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGG--QAPKAIRSVECYDFEE--DRWDQI-A 331
Query: 334 SLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLS 393
L R G+ + VY +GG N R YD ++W I S+Q+ + L
Sbjct: 332 ELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVD---VYDGVKDQWTSIASMQERRSTLG 388
Query: 394 VCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCG 453
V+ +YAV G D L +VE Y TN W +VAP+ + +EGK+Y G
Sbjct: 389 AAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGG 448
Query: 454 RRG--EDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDV 511
G L Y+P +N W +AD RR+ G+ L +LY GG + +
Sbjct: 449 YDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRK--- 505
Query: 512 HQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKD 571
V Y + W V + G+ ++ +YV+GG + V Y+ D
Sbjct: 506 -SVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLASVEYYNPVTD 562
Query: 572 CW 573
W
Sbjct: 563 KW 564
Score = 67.8 bits (164), Expect = 3e-11
Identities = 45/170 (26%), Positives = 74/170 (43%), Gaps = 3/170 (1%)
Query: 327 EWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQ 386
EW F A + R S+ G+ V+ +Y +GG + + S +Y+P N W + +
Sbjct: 420 EW-FFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASR-QCLSTVEQYNPATNEWIYVADMS 477
Query: 387 QEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEG 446
+ V V+ +YA G D +VE YDP TN+W VA + + G
Sbjct: 478 TRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNG 537
Query: 447 KMYITCGRRGEDYLKETHCYDPGSNTWHTL-ADGPVRRAWHGMATLLNKL 495
+Y+ G G L Y+P ++ W L + R++ G+A + L
Sbjct: 538 LLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
Score = 63.5 bits (153), Expect = 6e-10
Identities = 45/192 (23%), Positives = 75/192 (39%), Gaps = 4/192 (2%)
Query: 401 IYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYL 460
+ V G + +VE YD + W +A L + G +Y G G +
Sbjct: 302 VMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRV 361
Query: 461 KETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCT 520
+ YD + W ++A RR+ G A L + LY +GG + G + V YS
Sbjct: 362 RTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTG----LASVEAYSYK 417
Query: 521 SGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLD 580
+ +W V P+ G+ V++ ++Y +GG V Y+ + W +
Sbjct: 418 TNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMS 477
Query: 581 NSISGLAACVLT 592
SG VL+
Sbjct: 478 TRRSGAGVGVLS 489
Score = 63.2 bits (152), Expect = 7e-10
Identities = 41/141 (29%), Positives = 61/141 (43%), Gaps = 5/141 (3%)
Query: 304 GGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGF 363
GG LS +Y NP EW + A ++ R S G+ VL+ +Y GG + G
Sbjct: 447 GGYDGASRQCLSTVEQY-NPATNEWI-YVADMSTRRSGAGVGVLSGQLYATGGHD---GP 501
Query: 364 RAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPAT 423
YDP N W Q+ + + VC V +Y V G D +L +VE Y+P T
Sbjct: 502 LVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVT 561
Query: 424 NSWAYVAPLKREVYAHAGATL 444
+ W + ++AG +
Sbjct: 562 DKWTLLPTNMSTGRSYAGVAV 582
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 207 bits (528), Expect = 2e-53
Identities = 162/590 (27%), Positives = 261/590 (44%), Gaps = 29/590 (4%)
Query: 1 MAEEQEFTQLCKLPAQPSHPHCVNNTYRSAQ-----HSQALLRGLLALRDSGILFDVVLV 55
MA++ +L Q H +N T Q H++ LR + L DV+L+
Sbjct: 130 MADDNIEDSTARLDTQ--HSEDMNATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLI 187
Query: 56 VEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELEL 115
I AHR++L+A DYF MF + E +QEEV + GV NA+ ++ + YT L+L
Sbjct: 188 AGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQL 247
Query: 116 SLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYI 175
++ L AAC LQ+ ++I C +FL+ + N L + + + L Y
Sbjct: 248 KEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYT 307
Query: 176 LKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQAD-QISL 234
+++F+ + ++ LP ++ LL S+ + V E + +H ++ V D Q
Sbjct: 308 MEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETI------FHALMQWVGHDVQNRQ 361
Query: 235 HEPPKLLETVRFPLMEAEVLQRLHDK---LDPSPLRDTVASALMYHRNESLQPSLQSPQT 291
E LL +R PL+ ++L L + + A+ YH + +QSP+T
Sbjct: 362 GELGMLLSYIRLPLLPPQLLADLETSSMFTGDLECQKLLMEAMKYHLLPERRSMMQSPRT 421
Query: 292 ELR-SDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNF 350
+ R S + GG+ + T + KY + W H ++ R G+AV++N
Sbjct: 422 KPRKSTVGALYAVGGMDAMKGTTTIE--KY-DLRTNSWLHI-GTMNGRRLQFGVAVIDNK 477
Query: 351 VYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYH 410
+Y++GG + G + + ++P W + + L V + +YAV G D
Sbjct: 478 LYVVGGRD---GLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGW 534
Query: 411 NDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGS 470
+ LN VER+DP W YVA + L K+Y GR G LK +DP +
Sbjct: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHT 594
Query: 471 NTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYR--RDVHQVACYSCTSGQWSSVC 528
N W A RR G+AT LYV+GG + A R V Y WS+V
Sbjct: 595 NKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVA 654
Query: 529 PLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQ 578
PL + L +++YV+GG + T V YD +++ W+E Q
Sbjct: 655 PLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNT--VESYDAQRNEWKESMQ 702
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 204 bits (520), Expect = 2e-52
Identities = 153/571 (26%), Positives = 253/571 (44%), Gaps = 31/571 (5%)
Query: 32 HSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEV 91
H++++L + +LR S L DV L VE + AHRI+LAA DYF MF L E + V
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYV 74
Query: 92 LIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEEN 151
I G++ + M +L F+YT + +++ NVQE L AAC LQ+ + CC+FL S +D N
Sbjct: 75 DIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSN 134
Query: 152 ILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCET 211
L + AE + L + + + K+F + +++ L +V L+ + ++V E
Sbjct: 135 CLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEE 194
Query: 212 EVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPSPL----- 266
V+E + + ++ + + + P LL+ VR PL+ + D +D P
Sbjct: 195 PVFEAVINWVKHAKKEREESL-----PNLLQYVRMPLLTPRYIT---DVIDAEPFIRCSL 246
Query: 267 --RDTVASALMYHRNESLQPSLQSPQTELR---SDFQCVVGFGGIHSTPSTVLSDQAKYL 321
RD V A +H L+ +Q P+T R ++ VVG G +P V+ KY
Sbjct: 247 QCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVE---KY- 302
Query: 322 NPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNR-WF 380
+P EW F S+ + L++ +Y+IGG + + + C Y + W+
Sbjct: 303 DPKTQEWS-FLPSITRKRRYVASVSLHDRIYVIGGYDG-RSRLSSVECLDYTADEDGVWY 360
Query: 381 QIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHA 440
+ + +G IY G D ++ERYDP + W+ + ++
Sbjct: 361 SVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAG 420
Query: 441 GATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGG 500
G +Y G G + L YDP + W + +R+ G+A L + +YV+GG
Sbjct: 421 LVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG 480
Query: 501 SNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRT 560
+ A + V Y+ + W++V + G VL R+Y + G N S
Sbjct: 481 FDGTA----HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGN--SLL 534
Query: 561 GYVHIYDVEKDCWEEGPQLDNSISGLAACVL 591
+ YD D WE + CVL
Sbjct: 535 SSIECYDPIIDSWEVVTSMGTQRCDAGVCVL 565
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 189 bits (481), Expect = 5e-48
Identities = 152/550 (27%), Positives = 245/550 (44%), Gaps = 41/550 (7%)
Query: 30 AQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQE 89
+ H++ +L+ RDS + DV++ VEG+ HR +L+A YFR MF +E +
Sbjct: 46 SSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREM 105
Query: 90 EVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDE 149
V I+G+ AM L ++YT +++++ NVQ + QI + C FL +D
Sbjct: 106 LVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDP 165
Query: 150 ENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSC 209
N L + R A+ L L + + L+ F S+ +++ +L +++ + S+ L +
Sbjct: 166 CNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGK 225
Query: 210 ETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQR---LHDKLDPSP- 265
E V+E + + Y V + LHE LL VR PL+ + + + SP
Sbjct: 226 EEMVFEAVMRWVY--RAVDLRRPLLHE---LLTHVRLPLLHPNYFVQTVEVDQLIQNSPE 280
Query: 266 LRDTVASALMYH--RNESLQPSLQSPQTELRSDFQCVVG----FGGIHSTPSTVLSDQAK 319
+ A YH NE + P + ++ S+ VVG GG + P T D
Sbjct: 281 CYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGF-NLPYTECYD--- 336
Query: 320 YLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESR-CWRYDPRHNR 378
P+ GEWK S + L N + + GG R SR W Y+ + N
Sbjct: 337 ---PVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG-------RINSRDVWIYNSQLNI 386
Query: 379 WFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYA 438
W ++ SL + + V+ +Y V G D N L++VE YD +N W VAPLK V +
Sbjct: 387 WIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSS 446
Query: 439 HAGATLEGKMYITCGRRGEDYLKE-THCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYV 497
A + GK+++ G ++ + YDP +N+W A P+ + +L N +YV
Sbjct: 447 PAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYV 506
Query: 498 IGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRG 557
GG + CY W V + G++V + +IY+LGGR N G
Sbjct: 507 AGGLTK---------AIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRREN-G 556
Query: 558 SRTGYVHIYD 567
T + YD
Sbjct: 557 EATDTILCYD 566
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 185 bits (470), Expect = 1e-46
Identities = 149/577 (25%), Positives = 251/577 (43%), Gaps = 31/577 (5%)
Query: 40 LLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYN 99
LL ++G L DV L V + I H+++LA YFR MF + E +Q + I +
Sbjct: 57 LLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGD 116
Query: 100 AMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVDEENILDVYRLA 159
A+ ++ F+Y+S L L++ NVQ L AAC LQ+ + CC+++ N L V A
Sbjct: 117 AIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFA 176
Query: 160 ELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALL 219
E + L + D Y +F + + + + ++ LLSS+ L + E +VY A+
Sbjct: 177 ESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIK 236
Query: 220 YHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDK----LDPSPLRDTVASALM 275
+ + Q + + + L VR PL+ + L + K RD + A
Sbjct: 237 WLLANPQHHSKWLD-----ETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARN 291
Query: 276 YHRNESLQ--PSLQ-----SPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKYLNPLLGEW 328
YH + S + P + +P+ CV G GG + S + +N W
Sbjct: 292 YHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGG---SGDPFRSIECYSINK--NSW 346
Query: 329 KHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQE 388
F + R + G+ + VY +GG + + + +DP N+W S+ +
Sbjct: 347 -FFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSME---MFDPLTNKWMMKASMNTK 402
Query: 389 HADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYAHAGATLEGKM 448
+++ +G IYA+ G D + N VERYD ++ W+ VAP+ L +
Sbjct: 403 RRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHV 462
Query: 449 YITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYR 508
Y G G L YDP + W + + RRA +G++ L LYV+GG ++++
Sbjct: 463 YAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNS--- 519
Query: 509 RDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDV 568
+ V Y S +W V L G GIA + +I+ +GG HN + V +D
Sbjct: 520 -PLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGG--HNGNAYLNTVEAFDP 576
Query: 569 EKDCWEEGPQLDNSISGLAACVLTLPRSLLLEPPRGT 605
+ WE + + +G V + S + + G+
Sbjct: 577 VLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDVGHGS 613
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 184 bits (467), Expect = 2e-46
Identities = 156/601 (25%), Positives = 247/601 (41%), Gaps = 43/601 (7%)
Query: 11 CKLPAQPSHPHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVE-----GRHIEAHR 65
CK PS +Y H++ + LR S L DV L V+ AH+
Sbjct: 38 CKAEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHK 97
Query: 66 ILLAASCDYFRGMFAGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLV 125
++LA+S F+ MF GL+E E V I G+ M +++ F YT+ + + V +
Sbjct: 98 VVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMN 157
Query: 126 AACQLQIPEIIHFCCDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRT 185
A QI ++ C DFL+ +D N + + AE L ++ YI +F ++
Sbjct: 158 GAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQ 217
Query: 186 DKYRQLPLEKVYSLLSSNRLEVSCETEVYEGALLY-HYSLEQ----VQADQISLHEPPKL 240
+++ L ++ +L+S + L V CE+EV+ + + Y EQ VQA ++
Sbjct: 218 EEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLT 277
Query: 241 LETVRFPLMEAEVLQRLHDKLDPSPLRD---TVASALMYHRNESLQPSLQSPQTELRSDF 297
++ L + E+LQ S +D + L H+ + P ++P+
Sbjct: 278 PNFLQMQLQKCEILQ------SDSRCKDYLVKIFEELTLHKPTQVMPC-RAPKV------ 324
Query: 298 QCVVGFGGIHSTPSTVLSDQAKYL---NPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLI 354
G + T YL NP G W PR G V+ +Y +
Sbjct: 325 ------GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAG-CVVGGLLYAV 377
Query: 355 GGDNNVQGFRAESRCWR-YDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDL 413
GG NN +S Y+P N+W + + V V+ +IYAV G
Sbjct: 378 GGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHH 437
Query: 414 NAVERYDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTW 473
N+VERY+P + W VAP+ A L +Y G G + L CY P N W
Sbjct: 438 NSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEW 497
Query: 474 HTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAG 533
+ R+ G+ L N +Y GG + + ++ V Y + W+ V P+
Sbjct: 498 RMITAMNTIRSGAGVCVLHNCIYAAGGYDG----QDQLNSVERYDVETETWTFVAPMKHR 553
Query: 534 HGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTL 593
GI V RIYVLGG ++ + V YD + D W E ++ + SG+ V
Sbjct: 554 RSALGITVHQGRIYVLGG--YDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTME 611
Query: 594 P 594
P
Sbjct: 612 P 612
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,533,308
Number of Sequences: 37866
Number of extensions: 1177055
Number of successful extensions: 3608
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 175
Number of HSP's successfully gapped in prelim test: 25
Number of HSP's that attempted gapping in prelim test: 2380
Number of HSP's gapped (non-prelim): 385
length of query: 634
length of database: 18,247,518
effective HSP length: 108
effective length of query: 526
effective length of database: 14,157,990
effective search space: 7447102740
effective search space used: 7447102740
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.