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Search of human proteins with 24308191
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24308191 p21-activated kinase 7 [Homo sapiens]
(719 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|29826329 p21-activated kinase 7 [Homo sapiens] 1469 0.0
gi|24308191 p21-activated kinase 7 [Homo sapiens] 1469 0.0
gi|191252782 p21-activated kinase 6 [Homo sapiens] 559 e-159
gi|191252780 p21-activated kinase 6 [Homo sapiens] 559 e-159
gi|9910476 p21-activated kinase 6 [Homo sapiens] 559 e-159
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens] 522 e-148
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens] 522 e-148
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens] 522 e-148
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens] 511 e-145
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens] 511 e-145
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens] 317 3e-86
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens] 316 5e-86
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens] 316 5e-86
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens] 316 5e-86
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens] 316 5e-86
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens] 316 5e-86
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens] 316 5e-86
gi|32483399 p21-activated kinase 2 [Homo sapiens] 307 2e-83
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens] 299 5e-81
gi|103471999 serine/threonine kinase 3 [Homo sapiens] 201 2e-51
gi|5454096 serine/threonine kinase 4 [Homo sapiens] 201 2e-51
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens] 197 4e-50
gi|15451902 mitogen-activated protein kinase kinase kinase kinas... 196 6e-50
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens] 196 8e-50
gi|22035600 mitogen-activated protein kinase kinase kinase kinas... 191 2e-48
gi|38570135 mitogen-activated protein kinase kinase kinase kinas... 191 3e-48
gi|14589909 mitogen-activated protein kinase kinase kinase kinas... 191 3e-48
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo... 189 1e-47
gi|21361358 serine/threonine kinase 25 [Homo sapiens] 186 7e-47
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa... 185 1e-46
>gi|29826329 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 1469 bits (3803), Expect = 0.0
Identities = 719/719 (100%), Positives = 719/719 (100%)
Query: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT
Sbjct: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
Query: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA 120
PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA
Sbjct: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA 120
Query: 121 EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA 180
EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA
Sbjct: 121 EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA 180
Query: 181 YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA 240
YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA
Sbjct: 181 YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA 240
Query: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG 300
GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG
Sbjct: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG 300
Query: 301 ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS 360
ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS
Sbjct: 301 ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS 360
Query: 361 QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS 420
QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS
Sbjct: 361 QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS 420
Query: 421 DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM 480
DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM
Sbjct: 421 DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM 480
Query: 481 DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM 540
DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM
Sbjct: 481 DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM 540
Query: 541 NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR 600
NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR
Sbjct: 541 NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR 600
Query: 601 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP 660
KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP
Sbjct: 601 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP 660
Query: 661 PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 719
PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
Sbjct: 661 PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 719
>gi|24308191 p21-activated kinase 7 [Homo sapiens]
Length = 719
Score = 1469 bits (3803), Expect = 0.0
Identities = 719/719 (100%), Positives = 719/719 (100%)
Query: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT
Sbjct: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
Query: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA 120
PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA
Sbjct: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA 120
Query: 121 EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA 180
EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA
Sbjct: 121 EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA 180
Query: 181 YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA 240
YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA
Sbjct: 181 YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA 240
Query: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG 300
GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG
Sbjct: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG 300
Query: 301 ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS 360
ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS
Sbjct: 301 ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS 360
Query: 361 QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS 420
QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS
Sbjct: 361 QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS 420
Query: 421 DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM 480
DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM
Sbjct: 421 DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM 480
Query: 481 DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM 540
DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM
Sbjct: 481 DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM 540
Query: 541 NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR 600
NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR
Sbjct: 541 NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR 600
Query: 601 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP 660
KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP
Sbjct: 601 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP 660
Query: 661 PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 719
PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
Sbjct: 661 PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 719
>gi|191252782 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 559 bits (1441), Expect = e-159
Identities = 338/733 (46%), Positives = 442/733 (60%), Gaps = 81/733 (11%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQ 63
KKKK+ EIS P NF+HRVHT FDP+E KF GLP QW ++L DT RPKP+VDPS IT +Q
Sbjct: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63
Query: 64 LAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEEN 123
L PMKT+VRG+ + I+GLL D +SV SN+LR SP + + A+
Sbjct: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRR---------AQSL 114
Query: 124 GFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPY--YRGSHAAKQNGHVMKMKHGEAY 181
G + ++++ D Y E++ DP+ Y + GH +M E
Sbjct: 115 GLLGDEHWATDPDM---YLQSPQSERT------DPHGLYLSCNGGTPAGH-KQMPWPEPQ 164
Query: 182 YSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSS-PLDYSFQFTPSRTA 240
V P + L+ ++ S E+Q AS L Q +P +
Sbjct: 165 SPRVLP----------------NGLAAKAQ-SLGPAEFQGASQRCLQLGACLQSSPPGAS 207
Query: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQT--------SPQPTMRQRSRSGSGL 292
+G ++ + ++ + RP+S + SP P R+ S
Sbjct: 208 PPTGTNRHGMKAAKH------GSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLF 261
Query: 293 QEPMMPFGASAFKTH------PQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSP--PL 344
+ + A+A + PQ +S+ P+ P + K + + PL
Sbjct: 262 RSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPL 321
Query: 345 SGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSL 404
+ SDT P K ++ +G P+G + H + +S+ Y+
Sbjct: 322 TTSDT--SSPQKSLRTAPATG-QLPGRSSPAGSPRTW---HAQISTSNLYLPQD------ 369
Query: 405 SLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVC 464
P + G+ + + V+HEQF+AAL++VV GDPR L +++KIGEGSTGIVC
Sbjct: 370 -------PTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVC 422
Query: 465 IATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVME 524
+A EKH+G+QVAVK MDLRKQQRRELLFNEVVIMRDY H NVV+MY SYLVG+ELWV+ME
Sbjct: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLME 482
Query: 525 FLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKL 584
FL+GGALTDIV+ R+NEEQIATVC +VL+AL+YLH QGVIHRDIKSDSILLT DGR+KL
Sbjct: 483 FLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKL 542
Query: 585 SDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYF 644
SDFGFCAQ+SK+VPKRKSLVGTPYWMAPEVISR Y TEVDIWSLGIMVIEM+DGEPPYF
Sbjct: 543 SDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYF 602
Query: 645 NEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAG 704
++ P+QAM+R+RDS PP++K+ HKVS VLR FL+ MLVR+P +RATAQELL HPFL G
Sbjct: 603 SDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTG 662
Query: 705 PPSCIVPLMRQYR 717
P C+VPL++ YR
Sbjct: 663 LPECLVPLIQLYR 675
>gi|191252780 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 559 bits (1441), Expect = e-159
Identities = 338/733 (46%), Positives = 442/733 (60%), Gaps = 81/733 (11%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQ 63
KKKK+ EIS P NF+HRVHT FDP+E KF GLP QW ++L DT RPKP+VDPS IT +Q
Sbjct: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63
Query: 64 LAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEEN 123
L PMKT+VRG+ + I+GLL D +SV SN+LR SP + + A+
Sbjct: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRR---------AQSL 114
Query: 124 GFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPY--YRGSHAAKQNGHVMKMKHGEAY 181
G + ++++ D Y E++ DP+ Y + GH +M E
Sbjct: 115 GLLGDEHWATDPDM---YLQSPQSERT------DPHGLYLSCNGGTPAGH-KQMPWPEPQ 164
Query: 182 YSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSS-PLDYSFQFTPSRTA 240
V P + L+ ++ S E+Q AS L Q +P +
Sbjct: 165 SPRVLP----------------NGLAAKAQ-SLGPAEFQGASQRCLQLGACLQSSPPGAS 207
Query: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQT--------SPQPTMRQRSRSGSGL 292
+G ++ + ++ + RP+S + SP P R+ S
Sbjct: 208 PPTGTNRHGMKAAKH------GSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLF 261
Query: 293 QEPMMPFGASAFKTH------PQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSP--PL 344
+ + A+A + PQ +S+ P+ P + K + + PL
Sbjct: 262 RSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPL 321
Query: 345 SGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSL 404
+ SDT P K ++ +G P+G + H + +S+ Y+
Sbjct: 322 TTSDT--SSPQKSLRTAPATG-QLPGRSSPAGSPRTW---HAQISTSNLYLPQD------ 369
Query: 405 SLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVC 464
P + G+ + + V+HEQF+AAL++VV GDPR L +++KIGEGSTGIVC
Sbjct: 370 -------PTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVC 422
Query: 465 IATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVME 524
+A EKH+G+QVAVK MDLRKQQRRELLFNEVVIMRDY H NVV+MY SYLVG+ELWV+ME
Sbjct: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLME 482
Query: 525 FLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKL 584
FL+GGALTDIV+ R+NEEQIATVC +VL+AL+YLH QGVIHRDIKSDSILLT DGR+KL
Sbjct: 483 FLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKL 542
Query: 585 SDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYF 644
SDFGFCAQ+SK+VPKRKSLVGTPYWMAPEVISR Y TEVDIWSLGIMVIEM+DGEPPYF
Sbjct: 543 SDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYF 602
Query: 645 NEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAG 704
++ P+QAM+R+RDS PP++K+ HKVS VLR FL+ MLVR+P +RATAQELL HPFL G
Sbjct: 603 SDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTG 662
Query: 705 PPSCIVPLMRQYR 717
P C+VPL++ YR
Sbjct: 663 LPECLVPLIQLYR 675
>gi|9910476 p21-activated kinase 6 [Homo sapiens]
Length = 681
Score = 559 bits (1441), Expect = e-159
Identities = 338/733 (46%), Positives = 442/733 (60%), Gaps = 81/733 (11%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQ 63
KKKK+ EIS P NF+HRVHT FDP+E KF GLP QW ++L DT RPKP+VDPS IT +Q
Sbjct: 5 KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63
Query: 64 LAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEEN 123
L PMKT+VRG+ + I+GLL D +SV SN+LR SP + + A+
Sbjct: 64 LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRR---------AQSL 114
Query: 124 GFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPY--YRGSHAAKQNGHVMKMKHGEAY 181
G + ++++ D Y E++ DP+ Y + GH +M E
Sbjct: 115 GLLGDEHWATDPDM---YLQSPQSERT------DPHGLYLSCNGGTPAGH-KQMPWPEPQ 164
Query: 182 YSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSS-PLDYSFQFTPSRTA 240
V P + L+ ++ S E+Q AS L Q +P +
Sbjct: 165 SPRVLP----------------NGLAAKAQ-SLGPAEFQGASQRCLQLGACLQSSPPGAS 207
Query: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQT--------SPQPTMRQRSRSGSGL 292
+G ++ + ++ + RP+S + SP P R+ S
Sbjct: 208 PPTGTNRHGMKAAKH------GSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLF 261
Query: 293 QEPMMPFGASAFKTH------PQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSP--PL 344
+ + A+A + PQ +S+ P+ P + K + + PL
Sbjct: 262 RSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPL 321
Query: 345 SGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSL 404
+ SDT P K ++ +G P+G + H + +S+ Y+
Sbjct: 322 TTSDT--SSPQKSLRTAPATG-QLPGRSSPAGSPRTW---HAQISTSNLYLPQD------ 369
Query: 405 SLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVC 464
P + G+ + + V+HEQF+AAL++VV GDPR L +++KIGEGSTGIVC
Sbjct: 370 -------PTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVC 422
Query: 465 IATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVME 524
+A EKH+G+QVAVK MDLRKQQRRELLFNEVVIMRDY H NVV+MY SYLVG+ELWV+ME
Sbjct: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLME 482
Query: 525 FLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKL 584
FL+GGALTDIV+ R+NEEQIATVC +VL+AL+YLH QGVIHRDIKSDSILLT DGR+KL
Sbjct: 483 FLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKL 542
Query: 585 SDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYF 644
SDFGFCAQ+SK+VPKRKSLVGTPYWMAPEVISR Y TEVDIWSLGIMVIEM+DGEPPYF
Sbjct: 543 SDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYF 602
Query: 645 NEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAG 704
++ P+QAM+R+RDS PP++K+ HKVS VLR FL+ MLVR+P +RATAQELL HPFL G
Sbjct: 603 SDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTG 662
Query: 705 PPSCIVPLMRQYR 717
P C+VPL++ YR
Sbjct: 663 LPECLVPLIQLYR 675
>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 522 bits (1344), Expect = e-148
Identities = 291/464 (62%), Positives = 334/464 (71%), Gaps = 42/464 (9%)
Query: 265 DRRPKSSYLNQTSPQPTMR-QRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSE 323
++RPKSS PQ + R +R SG + P P G ++ G +N+Y
Sbjct: 157 EKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ-PAGLASGAKLAAGRPFNTY------- 208
Query: 324 PTMCIPKVDYDRAQMVLSPPLSGS-----DTYPRGPAK----LPQSQSKSGYSSSSHQYP 374
P+ D D P G+ D P GP+ +PQS SSSS + P
Sbjct: 209 -----PRADTDH-------PSRGAQGEPHDVAPNGPSAGGLAIPQS------SSSSSRPP 250
Query: 375 SGYHKATLYHHPSLQSSSQYISTASYLS-SLSLSSSTYPPPSWGSSSDQQPSRVSHEQFR 433
+ A PS + S + + ++ P P S ++P RVSHEQFR
Sbjct: 251 TRARGA-----PSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFR 305
Query: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN 493
AALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +GK VAVKKMDLRKQQRRELLFN
Sbjct: 306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 365
Query: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVL 553
EVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA VCL+VL
Sbjct: 366 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 425
Query: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613
+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCAQVSKEVP+RKSLVGTPYWMAPE
Sbjct: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
Query: 614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 673
+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+AM+ IRD+LPPR+K+LHKVS L
Sbjct: 486 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 545
Query: 674 RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYR 717
+GFLD +LVR+P+QRATA ELL HPFL AGPP+ IVPLMRQ R
Sbjct: 546 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 589
Score = 160 bits (405), Expect = 4e-39
Identities = 73/116 (62%), Positives = 94/116 (81%)
Query: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
MFGK+KK++EIS PSNFEHRVHTGFD EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
IQ KTIVRG+K K+ ++ LL++F+N+SVTRSNSLR++SPP P + +G
Sbjct: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENG 116
>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 522 bits (1344), Expect = e-148
Identities = 291/464 (62%), Positives = 334/464 (71%), Gaps = 42/464 (9%)
Query: 265 DRRPKSSYLNQTSPQPTMR-QRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSE 323
++RPKSS PQ + R +R SG + P P G ++ G +N+Y
Sbjct: 157 EKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ-PAGLASGAKLAAGRPFNTY------- 208
Query: 324 PTMCIPKVDYDRAQMVLSPPLSGS-----DTYPRGPAK----LPQSQSKSGYSSSSHQYP 374
P+ D D P G+ D P GP+ +PQS SSSS + P
Sbjct: 209 -----PRADTDH-------PSRGAQGEPHDVAPNGPSAGGLAIPQS------SSSSSRPP 250
Query: 375 SGYHKATLYHHPSLQSSSQYISTASYLS-SLSLSSSTYPPPSWGSSSDQQPSRVSHEQFR 433
+ A PS + S + + ++ P P S ++P RVSHEQFR
Sbjct: 251 TRARGA-----PSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFR 305
Query: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN 493
AALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +GK VAVKKMDLRKQQRRELLFN
Sbjct: 306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 365
Query: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVL 553
EVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA VCL+VL
Sbjct: 366 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 425
Query: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613
+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCAQVSKEVP+RKSLVGTPYWMAPE
Sbjct: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
Query: 614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 673
+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+AM+ IRD+LPPR+K+LHKVS L
Sbjct: 486 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 545
Query: 674 RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYR 717
+GFLD +LVR+P+QRATA ELL HPFL AGPP+ IVPLMRQ R
Sbjct: 546 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 589
Score = 160 bits (405), Expect = 4e-39
Identities = 73/116 (62%), Positives = 94/116 (81%)
Query: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
MFGK+KK++EIS PSNFEHRVHTGFD EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
IQ KTIVRG+K K+ ++ LL++F+N+SVTRSNSLR++SPP P + +G
Sbjct: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENG 116
>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
Length = 591
Score = 522 bits (1344), Expect = e-148
Identities = 291/464 (62%), Positives = 334/464 (71%), Gaps = 42/464 (9%)
Query: 265 DRRPKSSYLNQTSPQPTMR-QRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSE 323
++RPKSS PQ + R +R SG + P P G ++ G +N+Y
Sbjct: 157 EKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ-PAGLASGAKLAAGRPFNTY------- 208
Query: 324 PTMCIPKVDYDRAQMVLSPPLSGS-----DTYPRGPAK----LPQSQSKSGYSSSSHQYP 374
P+ D D P G+ D P GP+ +PQS SSSS + P
Sbjct: 209 -----PRADTDH-------PSRGAQGEPHDVAPNGPSAGGLAIPQS------SSSSSRPP 250
Query: 375 SGYHKATLYHHPSLQSSSQYISTASYLS-SLSLSSSTYPPPSWGSSSDQQPSRVSHEQFR 433
+ A PS + S + + ++ P P S ++P RVSHEQFR
Sbjct: 251 TRARGA-----PSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFR 305
Query: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN 493
AALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +GK VAVKKMDLRKQQRRELLFN
Sbjct: 306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 365
Query: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVL 553
EVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA VCL+VL
Sbjct: 366 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 425
Query: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613
+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCAQVSKEVP+RKSLVGTPYWMAPE
Sbjct: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485
Query: 614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 673
+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+AM+ IRD+LPPR+K+LHKVS L
Sbjct: 486 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 545
Query: 674 RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYR 717
+GFLD +LVR+P+QRATA ELL HPFL AGPP+ IVPLMRQ R
Sbjct: 546 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 589
Score = 160 bits (405), Expect = 4e-39
Identities = 73/116 (62%), Positives = 94/116 (81%)
Query: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
MFGK+KK++EIS PSNFEHRVHTGFD EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
IQ KTIVRG+K K+ ++ LL++F+N+SVTRSNSLR++SPP P + +G
Sbjct: 61 SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENG 116
>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 511 bits (1317), Expect = e-145
Identities = 253/306 (82%), Positives = 276/306 (90%)
Query: 412 PPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHT 471
P P S ++P RVSHEQFRAALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +
Sbjct: 131 PGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSS 190
Query: 472 GKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGAL 531
GK VAVKKMDLRKQQRRELLFNEVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGAL
Sbjct: 191 GKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGAL 250
Query: 532 TDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCA 591
TDIVTHTRMNEEQIA VCL+VL+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCA
Sbjct: 251 TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 310
Query: 592 QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQA 651
QVSKEVP+RKSLVGTPYWMAPE+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+A
Sbjct: 311 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 370
Query: 652 MRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVP 711
M+ IRD+LPPR+K+LHKVS L+GFLD +LVR+P+QRATA ELL HPFL AGPP+ IVP
Sbjct: 371 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 430
Query: 712 LMRQYR 717
LMRQ R
Sbjct: 431 LMRQNR 436
Score = 112 bits (280), Expect = 1e-24
Identities = 60/116 (51%), Positives = 78/116 (67%), Gaps = 9/116 (7%)
Query: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
MFGK+KK++EIS PSNFEHRVHTGFD EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
IQ K +P + + NG +++ +S+S PPT +GA S G
Sbjct: 61 SIQPGAPK-----GEP-HDVAPNG--PSAGGLAIPQSSS-SSSRPPTRARGAPSPG 107
>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
Length = 438
Score = 511 bits (1317), Expect = e-145
Identities = 253/306 (82%), Positives = 276/306 (90%)
Query: 412 PPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHT 471
P P S ++P RVSHEQFRAALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +
Sbjct: 131 PGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSS 190
Query: 472 GKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGAL 531
GK VAVKKMDLRKQQRRELLFNEVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGAL
Sbjct: 191 GKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGAL 250
Query: 532 TDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCA 591
TDIVTHTRMNEEQIA VCL+VL+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCA
Sbjct: 251 TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 310
Query: 592 QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQA 651
QVSKEVP+RKSLVGTPYWMAPE+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+A
Sbjct: 311 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 370
Query: 652 MRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVP 711
M+ IRD+LPPR+K+LHKVS L+GFLD +LVR+P+QRATA ELL HPFL AGPP+ IVP
Sbjct: 371 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 430
Query: 712 LMRQYR 717
LMRQ R
Sbjct: 431 LMRQNR 436
Score = 112 bits (280), Expect = 1e-24
Identities = 60/116 (51%), Positives = 78/116 (67%), Gaps = 9/116 (7%)
Query: 1 MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
MFGK+KK++EIS PSNFEHRVHTGFD EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1 MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60
Query: 61 PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
IQ K +P + + NG +++ +S+S PPT +GA S G
Sbjct: 61 SIQPGAPK-----GEP-HDVAPNG--PSAGGLAIPQSSS-SSSRPPTRARGAPSPG 107
>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
Length = 545
Score = 317 bits (811), Expect = 3e-86
Identities = 155/308 (50%), Positives = 225/308 (73%), Gaps = 2/308 (0%)
Query: 408 SSTYPPPSWGSSSDQQPSR--VSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCI 465
++T PP + ++++Q + +S E+ L+ +VS GDP++ F KIG+G++G V
Sbjct: 227 NNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYT 286
Query: 466 ATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEF 525
A + TG++VA+K+M+L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+
Sbjct: 287 AMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 346
Query: 526 LEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLS 585
L GG+LTD+VT T M+E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+
Sbjct: 347 LAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLT 406
Query: 586 DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFN 645
DFGFCAQ++ E KR ++VGTPYWMAPEV++R YG +VDIWSLGIM IEMI+GEPPY N
Sbjct: 407 DFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLN 466
Query: 646 EPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGP 705
E PL+A+ I + P +++ K+S++ R FL+ L + +R +A+ELL H FLK+A P
Sbjct: 467 ENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKP 526
Query: 706 PSCIVPLM 713
S + PL+
Sbjct: 527 LSSLTPLI 534
Score = 52.4 bits (124), Expect = 1e-06
Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
K+K++ EIS PS+FEH +H GFD +FTG+P+QW LL T+N K
Sbjct: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLL-QTSNITK 114
>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
Length = 559
Score = 316 bits (809), Expect = 5e-86
Identities = 152/292 (52%), Positives = 218/292 (74%)
Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
++ S+++ E+ L+ +VS GDP++ F KIG+G++G V A + TG++VA+K+M+
Sbjct: 256 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 315
Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 316 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 375
Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+DFGFCAQ++ E KR
Sbjct: 376 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 435
Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 495
Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
+++ ++S+V R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 496 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 547
Score = 42.4 bits (98), Expect = 0.002
Identities = 25/63 (39%), Positives = 34/63 (53%), Gaps = 16/63 (25%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFT---------------GLPQQWHSLLADTAN 48
K+K++ EIS PS+FEH +H GFD +FT G+P+QW LL T+N
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLL-QTSN 121
Query: 49 RPK 51
K
Sbjct: 122 ITK 124
>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
Length = 565
Score = 316 bits (809), Expect = 5e-86
Identities = 152/292 (52%), Positives = 218/292 (74%)
Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
++ S+++ E+ L+ +VS GDP++ F KIG+G++G V A + TG++VA+K+M+
Sbjct: 262 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 321
Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 322 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 381
Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+DFGFCAQ++ E KR
Sbjct: 382 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 441
Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 442 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 501
Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
+++ ++S+V R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 502 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 553
Score = 40.0 bits (92), Expect = 0.008
Identities = 18/35 (51%), Positives = 24/35 (68%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQ 38
K+K++ EIS PS+FEH +H GFD +FT P Q
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQ 97
>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
Length = 580
Score = 316 bits (809), Expect = 5e-86
Identities = 152/292 (52%), Positives = 218/292 (74%)
Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
++ S+++ E+ L+ +VS GDP++ F KIG+G++G V A + TG++VA+K+M+
Sbjct: 277 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 336
Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 337 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 396
Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+DFGFCAQ++ E KR
Sbjct: 397 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 456
Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 457 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 516
Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
+++ ++S+V R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 517 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 568
Score = 40.0 bits (92), Expect = 0.008
Identities = 18/35 (51%), Positives = 24/35 (68%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQ 38
K+K++ EIS PS+FEH +H GFD +FT P Q
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQ 97
>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 316 bits (809), Expect = 5e-86
Identities = 152/292 (52%), Positives = 218/292 (74%)
Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
++ S+++ E+ L+ +VS GDP++ F KIG+G++G V A + TG++VA+K+M+
Sbjct: 241 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 300
Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 301 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 360
Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+DFGFCAQ++ E KR
Sbjct: 361 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 420
Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 421 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 480
Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
+++ ++S+V R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 481 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532
Score = 52.4 bits (124), Expect = 1e-06
Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
K+K++ EIS PS+FEH +H GFD +FTG+P+QW LL T+N K
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLL-QTSNITK 109
>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 316 bits (809), Expect = 5e-86
Identities = 152/292 (52%), Positives = 218/292 (74%)
Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
++ S+++ E+ L+ +VS GDP++ F KIG+G++G V A + TG++VA+K+M+
Sbjct: 241 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 300
Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 301 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 360
Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+DFGFCAQ++ E KR
Sbjct: 361 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 420
Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 421 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 480
Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
+++ ++S+V R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 481 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532
Score = 52.4 bits (124), Expect = 1e-06
Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
K+K++ EIS PS+FEH +H GFD +FTG+P+QW LL T+N K
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLL-QTSNITK 109
>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
Length = 544
Score = 316 bits (809), Expect = 5e-86
Identities = 152/292 (52%), Positives = 218/292 (74%)
Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
++ S+++ E+ L+ +VS GDP++ F KIG+G++G V A + TG++VA+K+M+
Sbjct: 241 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 300
Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 301 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 360
Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+DFGFCAQ++ E KR
Sbjct: 361 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 420
Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 421 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 480
Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
+++ ++S+V R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 481 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532
Score = 52.4 bits (124), Expect = 1e-06
Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
K+K++ EIS PS+FEH +H GFD +FTG+P+QW LL T+N K
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLL-QTSNITK 109
>gi|32483399 p21-activated kinase 2 [Homo sapiens]
Length = 524
Score = 307 bits (787), Expect = 2e-83
Identities = 146/292 (50%), Positives = 216/292 (73%)
Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
++ ++++ E+ L+ +VS GDP++ + KIG+G++G V AT+ G++VA+K+++
Sbjct: 222 KKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQIN 281
Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
L+KQ ++EL+ NE+++M++ + N+V+ SYLVGDEL+VVME+L GG+LTD+VT T M+
Sbjct: 282 LQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMD 341
Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
E QIA VC L+AL +LH VIHRDIKSD++LL +G +KL+DFGFCAQ++ E KR
Sbjct: 342 EAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRS 401
Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
++VGTPYWMAPEV++R YG +VDIWSLGIM IEM++GEPPY NE PL+A+ I + P
Sbjct: 402 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 461
Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
+++ K+S + R FL+ L + +R +A+ELL HPFLKLA P S + PL+
Sbjct: 462 ELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLI 513
Score = 53.1 bits (126), Expect = 9e-07
Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
K+K++ EIS PS+FEH +H GFD +FTG+P+QW LL T+N K
Sbjct: 67 KEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLL-QTSNITK 113
>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
Length = 553
Score = 299 bits (766), Expect = 5e-81
Identities = 146/290 (50%), Positives = 213/290 (73%), Gaps = 2/290 (0%)
Query: 408 SSTYPPPSWGSSSDQQPSR--VSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCI 465
++T PP + ++++Q + +S E+ L+ +VS GDP++ F KIG+G++G V
Sbjct: 227 NNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYT 286
Query: 466 ATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEF 525
A + TG++VA+K+M+L++Q ++EL+ NE+++MR+ + N+V+ SYLVGDELWVVME+
Sbjct: 287 AMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 346
Query: 526 LEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLS 585
L GG+LTD+VT T M+E QIA VC L+AL +LH+ VIHRDIKSD+ILL DG +KL+
Sbjct: 347 LAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLT 406
Query: 586 DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFN 645
DFGFCAQ++ E KR ++VGTPYWMAPEV++R YG +VDIWSLGIM IEMI+GEPPY N
Sbjct: 407 DFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLN 466
Query: 646 EPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELL 695
E PL+A+ I + P +++ K+S++ R FL+ L + +R +A+ELL
Sbjct: 467 ENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELL 516
Score = 52.4 bits (124), Expect = 1e-06
Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)
Query: 4 KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
K+K++ EIS PS+FEH +H GFD +FTG+P+QW LL T+N K
Sbjct: 68 KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLL-QTSNITK 114
>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
Length = 491
Score = 201 bits (511), Expect = 2e-51
Identities = 109/273 (39%), Positives = 161/273 (58%), Gaps = 4/273 (1%)
Query: 445 PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHD 504
P E K+GEGS G V A K +G+ VA+K++ + + + E+ IM+
Sbjct: 23 PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE--IIKEISIMQQCDSP 80
Query: 505 NVVDMYSSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIATVCLSVLRALSYLHNQ 562
VV Y SY +LW+VME+ G+++DI+ + + E++IAT+ S L+ L YLH
Sbjct: 81 YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 140
Query: 563 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 622
IHRDIK+ +ILL ++G KL+DFG Q++ + KR +++GTP+WMAPEVI + Y
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 200
Query: 623 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV 682
DIWSLGI IEM +G+PPY + P++A+ I + PP + S F+ LV
Sbjct: 201 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 260
Query: 683 REPSQRATAQELLGHPFLKLAGPPSCIVPLMRQ 715
+ P QRATA +LL HPF+K A P S + L+ +
Sbjct: 261 KNPEQRATATQLLQHPFIKNAKPVSILRDLITE 293
>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
Length = 487
Score = 201 bits (511), Expect = 2e-51
Identities = 108/273 (39%), Positives = 161/273 (58%), Gaps = 4/273 (1%)
Query: 445 PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHD 504
P E K+GEGS G V A K TG+ VA+K++ + + + E+ IM+
Sbjct: 26 PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE--IIKEISIMQQCDSP 83
Query: 505 NVVDMYSSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIATVCLSVLRALSYLHNQ 562
+VV Y SY +LW+VME+ G+++DI+ + + E++IAT+ S L+ L YLH
Sbjct: 84 HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFM 143
Query: 563 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 622
IHRDIK+ +ILL ++G KL+DFG Q++ + KR +++GTP+WMAPEVI + Y
Sbjct: 144 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 203
Query: 623 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV 682
DIWSLGI IEM +G+PPY + P++A+ I + PP + S F+ LV
Sbjct: 204 VADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLV 263
Query: 683 REPSQRATAQELLGHPFLKLAGPPSCIVPLMRQ 715
+ P QRATA +LL HPF++ A S + L+ +
Sbjct: 264 KSPEQRATATQLLQHPFVRSAKGVSILRDLINE 296
>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
Length = 443
Score = 197 bits (500), Expect = 4e-50
Identities = 112/304 (36%), Positives = 174/304 (57%), Gaps = 9/304 (2%)
Query: 416 WGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQV 475
WG + +++ + + H L+ DP E KIG+GS G V + T K V
Sbjct: 8 WGLALNKRRATLPHPGGSTNLK-----ADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVV 62
Query: 476 AVKKMDLRKQQRR-ELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDI 534
A+K +DL + + E + E+ ++ V Y SYL +LW++ME+L GG+ D+
Sbjct: 63 AIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL 122
Query: 535 VTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVS 594
+ ++E QIAT+ +L+ L YLH++ IHRDIK+ ++LL+ G +KL+DFG Q++
Sbjct: 123 LEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLT 182
Query: 595 KEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRR 654
KR + VGTP+WMAPEVI + Y ++ DIWSLGI IE+ GEPP+ P++ +
Sbjct: 183 DTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFL 242
Query: 655 IRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPF-LKLAGPPSCIVPLM 713
I + PP ++ S L+ F++ L +EPS R TA+ELL H F L+ A S + L+
Sbjct: 243 IPKNNPPTLEG--NYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI 300
Query: 714 RQYR 717
+Y+
Sbjct: 301 DRYK 304
>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
[Homo sapiens]
Length = 894
Score = 196 bits (498), Expect = 6e-50
Identities = 107/267 (40%), Positives = 165/267 (61%), Gaps = 6/267 (2%)
Query: 440 VSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMR 499
+S +P+E +IG G+ G V A +TG+ A+K + L + ++ E+++M+
Sbjct: 7 LSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMK 66
Query: 500 DYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVLRALSY 558
D H N+V + SYL D+LW+ MEF GG+L DI T ++E QIA V L+ L Y
Sbjct: 67 DCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYY 126
Query: 559 LHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS-- 616
LH++G +HRDIK +ILLT +G +KL+DFG AQ++ + KRKS +GTPYWMAPEV +
Sbjct: 127 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE 186
Query: 617 -RLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDS--LPPRVKDLHKVSSVL 673
+ Y D+W++GI IE+ + +PP F+ P++A+ + S PP++KD K S+
Sbjct: 187 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSF 246
Query: 674 RGFLDLMLVREPSQRATAQELLGHPFL 700
F+ + L + P +R TA++LL HPF+
Sbjct: 247 HHFVKMALTKNPKKRPTAEKLLQHPFV 273
>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
Length = 431
Score = 196 bits (497), Expect = 8e-50
Identities = 108/276 (39%), Positives = 163/276 (59%), Gaps = 4/276 (1%)
Query: 444 DPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR-ELLFNEVVIMRDYH 502
DP E KIG+GS G V + T K VA+K +DL + + E + E+ ++
Sbjct: 19 DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 503 HDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQ 562
V Y SYL +LW++ME+L GG+ D++ ++E QIAT+ +L+ L YLH++
Sbjct: 79 SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 138
Query: 563 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 622
IHRDIK+ ++LL+ G +KL+DFG Q++ KR + VGTP+WMAPEVI + Y +
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198
Query: 623 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV 682
+ DIWSLGI IE+ GEPP+ P++ + I + PP ++ S L+ F++ L
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 256
Query: 683 REPSQRATAQELLGHPF-LKLAGPPSCIVPLMRQYR 717
+EPS R TA+ELL H F L+ A S + L+ +Y+
Sbjct: 257 KEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYK 292
>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
[Homo sapiens]
Length = 820
Score = 191 bits (486), Expect = 2e-48
Identities = 112/285 (39%), Positives = 162/285 (56%), Gaps = 6/285 (2%)
Query: 435 ALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNE 494
AL VS DPR+ ++G G+ G V A + T + AVK + L L E
Sbjct: 2 ALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQE 61
Query: 495 VVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVL 553
+ I+R+ H NVV SYL D LW+ MEF GG+L +I T + E QIA VC L
Sbjct: 62 ITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREAL 121
Query: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613
+ L +LH+QG IHRDIK ++LLT G +KL+DFG +++ V KR+S +GTPYWMAPE
Sbjct: 122 KGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPE 181
Query: 614 VIS---RLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDS--LPPRVKDLHK 668
V + + Y D+W+LGI IE+ + +PP F+ P++A+ + S PP+++D +
Sbjct: 182 VAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTR 241
Query: 669 VSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
+ FL L L + P +R TA++LL HPF P + + L+
Sbjct: 242 WTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLL 286
>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 191 bits (484), Expect = 3e-48
Identities = 104/257 (40%), Positives = 155/257 (60%), Gaps = 6/257 (2%)
Query: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSY 513
++G G+ G V A HTG+ AVK + L L+ E+ ++++ H N+V + SY
Sbjct: 25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSY 84
Query: 514 LVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSD 572
L ++LW+ ME+ GG+L DI T ++E QIA VC L+ L+YLH +G +HRDIK
Sbjct: 85 LSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGA 144
Query: 573 SILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS---RLPYGTEVDIWSL 629
+ILLT G +KL+DFG A+++ + KRKS +GTPYWMAPEV + Y DIW++
Sbjct: 145 NILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAV 204
Query: 630 GIMVIEMIDGEPPYFNEPPLQAMRRIRDS--LPPRVKDLHKVSSVLRGFLDLMLVREPSQ 687
GI IE+ + +PP F+ P++A+ + S PP++KD K SS F+ + L + P +
Sbjct: 205 GITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKK 264
Query: 688 RATAQELLGHPFLKLAG 704
R TA+ LL H F+ G
Sbjct: 265 RPTAERLLTHTFVAQPG 281
>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
[Homo sapiens]
Length = 846
Score = 191 bits (484), Expect = 3e-48
Identities = 104/257 (40%), Positives = 155/257 (60%), Gaps = 6/257 (2%)
Query: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSY 513
++G G+ G V A HTG+ AVK + L L+ E+ ++++ H N+V + SY
Sbjct: 25 RVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSY 84
Query: 514 LVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSD 572
L ++LW+ ME+ GG+L DI T ++E QIA VC L+ L+YLH +G +HRDIK
Sbjct: 85 LSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGA 144
Query: 573 SILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS---RLPYGTEVDIWSL 629
+ILLT G +KL+DFG A+++ + KRKS +GTPYWMAPEV + Y DIW++
Sbjct: 145 NILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAV 204
Query: 630 GIMVIEMIDGEPPYFNEPPLQAMRRIRDS--LPPRVKDLHKVSSVLRGFLDLMLVREPSQ 687
GI IE+ + +PP F+ P++A+ + S PP++KD K SS F+ + L + P +
Sbjct: 205 GITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKK 264
Query: 688 RATAQELLGHPFLKLAG 704
R TA+ LL H F+ G
Sbjct: 265 RPTAERLLTHTFVAQPG 281
>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
sapiens]
Length = 416
Score = 189 bits (479), Expect = 1e-47
Identities = 100/258 (38%), Positives = 153/258 (59%), Gaps = 3/258 (1%)
Query: 444 DPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR-ELLFNEVVIMRDYH 502
DP E +IG+GS G V + T + VA+K +DL + + E + E+ ++
Sbjct: 19 DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78
Query: 503 HDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQ 562
V Y SYL G +LW++ME+L GG+ D++ +E QIAT+ +L+ L YLH++
Sbjct: 79 SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSE 138
Query: 563 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 622
IHRDIK+ ++LL+ G +KL+DFG Q++ KR + VGTP+WMAPEVI + Y +
Sbjct: 139 KKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 198
Query: 623 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV 682
+ DIWSLGI IE+ GEPP + P++ + I + PP + + + + F+D L
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL--VGDFTKSFKEFIDACLN 256
Query: 683 REPSQRATAQELLGHPFL 700
++PS R TA+ELL H F+
Sbjct: 257 KDPSFRPTAKELLKHKFI 274
>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
Length = 426
Score = 186 bits (472), Expect = 7e-47
Identities = 100/276 (36%), Positives = 159/276 (57%), Gaps = 4/276 (1%)
Query: 444 DPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR-ELLFNEVVIMRDYH 502
DP E +IG+GS G V + HT + VA+K +DL + + E + E+ ++
Sbjct: 15 DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74
Query: 503 HDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQ 562
+ + SYL +LW++ME+L GG+ D++ + E IAT+ +L+ L YLH++
Sbjct: 75 SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSE 134
Query: 563 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 622
IHRDIK+ ++LL+ G +KL+DFG Q++ KR + VGTP+WMAPEVI + Y
Sbjct: 135 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF 194
Query: 623 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV 682
+ DIWSLGI IE+ GEPP + P++ + I + PP ++ H S + F++ L
Sbjct: 195 KADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH--SKPFKEFVEACLN 252
Query: 683 REPSQRATAQELLGHPFL-KLAGPPSCIVPLMRQYR 717
++P R TA+ELL H F+ + S + L+ +Y+
Sbjct: 253 KDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288
>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
sapiens]
Length = 1268
Score = 185 bits (470), Expect = 1e-46
Identities = 101/262 (38%), Positives = 156/262 (59%), Gaps = 17/262 (6%)
Query: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDY-HHDNVVDMYSSY 513
+G G+ G V TG+ A+K MD+ + E+ E+ +++ Y HH N+ Y ++
Sbjct: 31 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK-QEINMLKKYSHHRNIATYYGAF 89
Query: 514 L------VGDELWVVMEFLEGGALTDIVTHTRMN---EEQIATVCLSVLRALSYLHNQGV 564
+ + D+LW+VMEF G++TD++ +T+ N EE IA +C +LR LS+LH V
Sbjct: 90 IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149
Query: 565 IHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS-----RLP 619
IHRDIK ++LLT + +KL DFG AQ+ + V +R + +GTPYWMAPEVI+
Sbjct: 150 IHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDAT 209
Query: 620 YGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDL 679
Y + D+WSLGI IEM +G PP + P++A+ I + PR+K K S + F++
Sbjct: 210 YDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KKWSKKFQSFIES 268
Query: 680 MLVREPSQRATAQELLGHPFLK 701
LV+ SQR ++L+ HPF++
Sbjct: 269 CLVKNHSQRPATEQLMKHPFIR 290
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.131 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,083,656
Number of Sequences: 37866
Number of extensions: 1513917
Number of successful extensions: 6352
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 712
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 3758
Number of HSP's gapped (non-prelim): 1260
length of query: 719
length of database: 18,247,518
effective HSP length: 110
effective length of query: 609
effective length of database: 14,082,258
effective search space: 8576095122
effective search space used: 8576095122
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.