Guide to the Human Genome
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Search of human proteins with 24308191

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|24308191 p21-activated kinase 7 [Homo sapiens]
         (719 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|29826329 p21-activated kinase 7 [Homo sapiens]                    1469   0.0  
gi|24308191 p21-activated kinase 7 [Homo sapiens]                    1469   0.0  
gi|191252782 p21-activated kinase 6 [Homo sapiens]                    559   e-159
gi|191252780 p21-activated kinase 6 [Homo sapiens]                    559   e-159
gi|9910476 p21-activated kinase 6 [Homo sapiens]                      559   e-159
gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]           522   e-148
gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]           522   e-148
gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]            522   e-148
gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]           511   e-145
gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]           511   e-145
gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]           317   3e-86
gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]          316   5e-86
gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]          316   5e-86
gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]          316   5e-86
gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]          316   5e-86
gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]          316   5e-86
gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]            316   5e-86
gi|32483399 p21-activated kinase 2 [Homo sapiens]                     307   2e-83
gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]          299   5e-81
gi|103471999 serine/threonine kinase 3 [Homo sapiens]                 201   2e-51
gi|5454096 serine/threonine kinase 4 [Homo sapiens]                   201   2e-51
gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]       197   4e-50
gi|15451902 mitogen-activated protein kinase kinase kinase kinas...   196   6e-50
gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]      196   8e-50
gi|22035600 mitogen-activated protein kinase kinase kinase kinas...   191   2e-48
gi|38570135 mitogen-activated protein kinase kinase kinase kinas...   191   3e-48
gi|14589909 mitogen-activated protein kinase kinase kinase kinas...   191   3e-48
gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo...   189   1e-47
gi|21361358 serine/threonine kinase 25 [Homo sapiens]                 186   7e-47
gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo sa...   185   1e-46

>gi|29826329 p21-activated kinase 7 [Homo sapiens]
          Length = 719

 Score = 1469 bits (3803), Expect = 0.0
 Identities = 719/719 (100%), Positives = 719/719 (100%)

Query: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
           MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT
Sbjct: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60

Query: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA 120
           PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA
Sbjct: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA 120

Query: 121 EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA 180
           EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA
Sbjct: 121 EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA 180

Query: 181 YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA 240
           YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA
Sbjct: 181 YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA 240

Query: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG 300
           GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG
Sbjct: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG 300

Query: 301 ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS 360
           ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS
Sbjct: 301 ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS 360

Query: 361 QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS 420
           QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS
Sbjct: 361 QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS 420

Query: 421 DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM 480
           DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM
Sbjct: 421 DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM 480

Query: 481 DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM 540
           DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM
Sbjct: 481 DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM 540

Query: 541 NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR 600
           NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR
Sbjct: 541 NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR 600

Query: 601 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP 660
           KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP
Sbjct: 601 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP 660

Query: 661 PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 719
           PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
Sbjct: 661 PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 719


>gi|24308191 p21-activated kinase 7 [Homo sapiens]
          Length = 719

 Score = 1469 bits (3803), Expect = 0.0
 Identities = 719/719 (100%), Positives = 719/719 (100%)

Query: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
           MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT
Sbjct: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60

Query: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA 120
           PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA
Sbjct: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHA 120

Query: 121 EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA 180
           EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA
Sbjct: 121 EENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEA 180

Query: 181 YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA 240
           YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA
Sbjct: 181 YYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTA 240

Query: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG 300
           GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG
Sbjct: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFG 300

Query: 301 ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS 360
           ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS
Sbjct: 301 ASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQS 360

Query: 361 QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS 420
           QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS
Sbjct: 361 QSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSS 420

Query: 421 DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM 480
           DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM
Sbjct: 421 DQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKM 480

Query: 481 DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM 540
           DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM
Sbjct: 481 DLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRM 540

Query: 541 NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR 600
           NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR
Sbjct: 541 NEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKR 600

Query: 601 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP 660
           KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP
Sbjct: 601 KSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLP 660

Query: 661 PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 719
           PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
Sbjct: 661 PRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH 719


>gi|191252782 p21-activated kinase 6 [Homo sapiens]
          Length = 681

 Score =  559 bits (1441), Expect = e-159
 Identities = 338/733 (46%), Positives = 442/733 (60%), Gaps = 81/733 (11%)

Query: 4   KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQ 63
           KKKK+ EIS P NF+HRVHT FDP+E KF GLP QW ++L DT  RPKP+VDPS IT +Q
Sbjct: 5   KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63

Query: 64  LAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEEN 123
           L PMKT+VRG+    +  I+GLL D   +SV  SN+LR  SP +  +         A+  
Sbjct: 64  LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRR---------AQSL 114

Query: 124 GFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPY--YRGSHAAKQNGHVMKMKHGEAY 181
           G +    ++++ D    Y      E++      DP+  Y   +     GH  +M   E  
Sbjct: 115 GLLGDEHWATDPDM---YLQSPQSERT------DPHGLYLSCNGGTPAGH-KQMPWPEPQ 164

Query: 182 YSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSS-PLDYSFQFTPSRTA 240
              V P                + L+  ++ S    E+Q AS     L    Q +P   +
Sbjct: 165 SPRVLP----------------NGLAAKAQ-SLGPAEFQGASQRCLQLGACLQSSPPGAS 207

Query: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQT--------SPQPTMRQRSRSGSGL 292
             +G ++  +  ++          + RP+S  +           SP P  R+ S      
Sbjct: 208 PPTGTNRHGMKAAKH------GSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLF 261

Query: 293 QEPMMPFGASAFKTH------PQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSP--PL 344
           +   +   A+A  +       PQ    +S+  P+   P   + K     +   +    PL
Sbjct: 262 RSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPL 321

Query: 345 SGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSL 404
           + SDT    P K  ++   +G        P+G  +     H  + +S+ Y+         
Sbjct: 322 TTSDT--SSPQKSLRTAPATG-QLPGRSSPAGSPRTW---HAQISTSNLYLPQD------ 369

Query: 405 SLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVC 464
                  P  + G+ + +    V+HEQF+AAL++VV  GDPR  L +++KIGEGSTGIVC
Sbjct: 370 -------PTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVC 422

Query: 465 IATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVME 524
           +A EKH+G+QVAVK MDLRKQQRRELLFNEVVIMRDY H NVV+MY SYLVG+ELWV+ME
Sbjct: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLME 482

Query: 525 FLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKL 584
           FL+GGALTDIV+  R+NEEQIATVC +VL+AL+YLH QGVIHRDIKSDSILLT DGR+KL
Sbjct: 483 FLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKL 542

Query: 585 SDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYF 644
           SDFGFCAQ+SK+VPKRKSLVGTPYWMAPEVISR  Y TEVDIWSLGIMVIEM+DGEPPYF
Sbjct: 543 SDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYF 602

Query: 645 NEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAG 704
           ++ P+QAM+R+RDS PP++K+ HKVS VLR FL+ MLVR+P +RATAQELL HPFL   G
Sbjct: 603 SDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTG 662

Query: 705 PPSCIVPLMRQYR 717
            P C+VPL++ YR
Sbjct: 663 LPECLVPLIQLYR 675


>gi|191252780 p21-activated kinase 6 [Homo sapiens]
          Length = 681

 Score =  559 bits (1441), Expect = e-159
 Identities = 338/733 (46%), Positives = 442/733 (60%), Gaps = 81/733 (11%)

Query: 4   KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQ 63
           KKKK+ EIS P NF+HRVHT FDP+E KF GLP QW ++L DT  RPKP+VDPS IT +Q
Sbjct: 5   KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63

Query: 64  LAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEEN 123
           L PMKT+VRG+    +  I+GLL D   +SV  SN+LR  SP +  +         A+  
Sbjct: 64  LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRR---------AQSL 114

Query: 124 GFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPY--YRGSHAAKQNGHVMKMKHGEAY 181
           G +    ++++ D    Y      E++      DP+  Y   +     GH  +M   E  
Sbjct: 115 GLLGDEHWATDPDM---YLQSPQSERT------DPHGLYLSCNGGTPAGH-KQMPWPEPQ 164

Query: 182 YSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSS-PLDYSFQFTPSRTA 240
              V P                + L+  ++ S    E+Q AS     L    Q +P   +
Sbjct: 165 SPRVLP----------------NGLAAKAQ-SLGPAEFQGASQRCLQLGACLQSSPPGAS 207

Query: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQT--------SPQPTMRQRSRSGSGL 292
             +G ++  +  ++          + RP+S  +           SP P  R+ S      
Sbjct: 208 PPTGTNRHGMKAAKH------GSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLF 261

Query: 293 QEPMMPFGASAFKTH------PQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSP--PL 344
           +   +   A+A  +       PQ    +S+  P+   P   + K     +   +    PL
Sbjct: 262 RSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPL 321

Query: 345 SGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSL 404
           + SDT    P K  ++   +G        P+G  +     H  + +S+ Y+         
Sbjct: 322 TTSDT--SSPQKSLRTAPATG-QLPGRSSPAGSPRTW---HAQISTSNLYLPQD------ 369

Query: 405 SLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVC 464
                  P  + G+ + +    V+HEQF+AAL++VV  GDPR  L +++KIGEGSTGIVC
Sbjct: 370 -------PTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVC 422

Query: 465 IATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVME 524
           +A EKH+G+QVAVK MDLRKQQRRELLFNEVVIMRDY H NVV+MY SYLVG+ELWV+ME
Sbjct: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLME 482

Query: 525 FLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKL 584
           FL+GGALTDIV+  R+NEEQIATVC +VL+AL+YLH QGVIHRDIKSDSILLT DGR+KL
Sbjct: 483 FLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKL 542

Query: 585 SDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYF 644
           SDFGFCAQ+SK+VPKRKSLVGTPYWMAPEVISR  Y TEVDIWSLGIMVIEM+DGEPPYF
Sbjct: 543 SDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYF 602

Query: 645 NEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAG 704
           ++ P+QAM+R+RDS PP++K+ HKVS VLR FL+ MLVR+P +RATAQELL HPFL   G
Sbjct: 603 SDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTG 662

Query: 705 PPSCIVPLMRQYR 717
            P C+VPL++ YR
Sbjct: 663 LPECLVPLIQLYR 675


>gi|9910476 p21-activated kinase 6 [Homo sapiens]
          Length = 681

 Score =  559 bits (1441), Expect = e-159
 Identities = 338/733 (46%), Positives = 442/733 (60%), Gaps = 81/733 (11%)

Query: 4   KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQ 63
           KKKK+ EIS P NF+HRVHT FDP+E KF GLP QW ++L DT  RPKP+VDPS IT +Q
Sbjct: 5   KKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNIL-DTLRRPKPVVDPSRITRVQ 63

Query: 64  LAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEEN 123
           L PMKT+VRG+    +  I+GLL D   +SV  SN+LR  SP +  +         A+  
Sbjct: 64  LQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRR---------AQSL 114

Query: 124 GFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPY--YRGSHAAKQNGHVMKMKHGEAY 181
           G +    ++++ D    Y      E++      DP+  Y   +     GH  +M   E  
Sbjct: 115 GLLGDEHWATDPDM---YLQSPQSERT------DPHGLYLSCNGGTPAGH-KQMPWPEPQ 164

Query: 182 YSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSS-PLDYSFQFTPSRTA 240
              V P                + L+  ++ S    E+Q AS     L    Q +P   +
Sbjct: 165 SPRVLP----------------NGLAAKAQ-SLGPAEFQGASQRCLQLGACLQSSPPGAS 207

Query: 241 GTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQT--------SPQPTMRQRSRSGSGL 292
             +G ++  +  ++          + RP+S  +           SP P  R+ S      
Sbjct: 208 PPTGTNRHGMKAAKH------GSEEARPQSCLVGSATGRPGGEGSPSPKTRESSLKRRLF 261

Query: 293 QEPMMPFGASAFKTH------PQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSP--PL 344
           +   +   A+A  +       PQ    +S+  P+   P   + K     +   +    PL
Sbjct: 262 RSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPPSLVAKAQSLPSDQPVGTFSPL 321

Query: 345 SGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSL 404
           + SDT    P K  ++   +G        P+G  +     H  + +S+ Y+         
Sbjct: 322 TTSDT--SSPQKSLRTAPATG-QLPGRSSPAGSPRTW---HAQISTSNLYLPQD------ 369

Query: 405 SLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVC 464
                  P  + G+ + +    V+HEQF+AAL++VV  GDPR  L +++KIGEGSTGIVC
Sbjct: 370 -------PTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGIVC 422

Query: 465 IATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVME 524
           +A EKH+G+QVAVK MDLRKQQRRELLFNEVVIMRDY H NVV+MY SYLVG+ELWV+ME
Sbjct: 423 LAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVLME 482

Query: 525 FLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKL 584
           FL+GGALTDIV+  R+NEEQIATVC +VL+AL+YLH QGVIHRDIKSDSILLT DGR+KL
Sbjct: 483 FLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRVKL 542

Query: 585 SDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYF 644
           SDFGFCAQ+SK+VPKRKSLVGTPYWMAPEVISR  Y TEVDIWSLGIMVIEM+DGEPPYF
Sbjct: 543 SDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPPYF 602

Query: 645 NEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAG 704
           ++ P+QAM+R+RDS PP++K+ HKVS VLR FL+ MLVR+P +RATAQELL HPFL   G
Sbjct: 603 SDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQTG 662

Query: 705 PPSCIVPLMRQYR 717
            P C+VPL++ YR
Sbjct: 663 LPECLVPLIQLYR 675


>gi|62422554 p21-activated kinase 4 isoform 1 [Homo sapiens]
          Length = 591

 Score =  522 bits (1344), Expect = e-148
 Identities = 291/464 (62%), Positives = 334/464 (71%), Gaps = 42/464 (9%)

Query: 265 DRRPKSSYLNQTSPQPTMR-QRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSE 323
           ++RPKSS      PQ + R +R  SG  +  P  P G ++      G  +N+Y       
Sbjct: 157 EKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ-PAGLASGAKLAAGRPFNTY------- 208

Query: 324 PTMCIPKVDYDRAQMVLSPPLSGS-----DTYPRGPAK----LPQSQSKSGYSSSSHQYP 374
                P+ D D        P  G+     D  P GP+     +PQS      SSSS + P
Sbjct: 209 -----PRADTDH-------PSRGAQGEPHDVAPNGPSAGGLAIPQS------SSSSSRPP 250

Query: 375 SGYHKATLYHHPSLQSSSQYISTASYLS-SLSLSSSTYPPPSWGSSSDQQPSRVSHEQFR 433
           +    A     PS      + S       + + ++   P P    S  ++P RVSHEQFR
Sbjct: 251 TRARGA-----PSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFR 305

Query: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN 493
           AALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +GK VAVKKMDLRKQQRRELLFN
Sbjct: 306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 365

Query: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVL 553
           EVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA VCL+VL
Sbjct: 366 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 425

Query: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613
           +ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCAQVSKEVP+RKSLVGTPYWMAPE
Sbjct: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485

Query: 614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 673
           +ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+AM+ IRD+LPPR+K+LHKVS  L
Sbjct: 486 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 545

Query: 674 RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYR 717
           +GFLD +LVR+P+QRATA ELL HPFL  AGPP+ IVPLMRQ R
Sbjct: 546 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 589



 Score =  160 bits (405), Expect = 4e-39
 Identities = 73/116 (62%), Positives = 94/116 (81%)

Query: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
           MFGK+KK++EIS PSNFEHRVHTGFD  EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60

Query: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
            IQ    KTIVRG+K  K+ ++  LL++F+N+SVTRSNSLR++SPP P +    +G
Sbjct: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENG 116


>gi|62422557 p21-activated kinase 4 isoform 1 [Homo sapiens]
          Length = 591

 Score =  522 bits (1344), Expect = e-148
 Identities = 291/464 (62%), Positives = 334/464 (71%), Gaps = 42/464 (9%)

Query: 265 DRRPKSSYLNQTSPQPTMR-QRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSE 323
           ++RPKSS      PQ + R +R  SG  +  P  P G ++      G  +N+Y       
Sbjct: 157 EKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ-PAGLASGAKLAAGRPFNTY------- 208

Query: 324 PTMCIPKVDYDRAQMVLSPPLSGS-----DTYPRGPAK----LPQSQSKSGYSSSSHQYP 374
                P+ D D        P  G+     D  P GP+     +PQS      SSSS + P
Sbjct: 209 -----PRADTDH-------PSRGAQGEPHDVAPNGPSAGGLAIPQS------SSSSSRPP 250

Query: 375 SGYHKATLYHHPSLQSSSQYISTASYLS-SLSLSSSTYPPPSWGSSSDQQPSRVSHEQFR 433
           +    A     PS      + S       + + ++   P P    S  ++P RVSHEQFR
Sbjct: 251 TRARGA-----PSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFR 305

Query: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN 493
           AALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +GK VAVKKMDLRKQQRRELLFN
Sbjct: 306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 365

Query: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVL 553
           EVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA VCL+VL
Sbjct: 366 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 425

Query: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613
           +ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCAQVSKEVP+RKSLVGTPYWMAPE
Sbjct: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485

Query: 614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 673
           +ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+AM+ IRD+LPPR+K+LHKVS  L
Sbjct: 486 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 545

Query: 674 RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYR 717
           +GFLD +LVR+P+QRATA ELL HPFL  AGPP+ IVPLMRQ R
Sbjct: 546 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 589



 Score =  160 bits (405), Expect = 4e-39
 Identities = 73/116 (62%), Positives = 94/116 (81%)

Query: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
           MFGK+KK++EIS PSNFEHRVHTGFD  EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60

Query: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
            IQ    KTIVRG+K  K+ ++  LL++F+N+SVTRSNSLR++SPP P +    +G
Sbjct: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENG 116


>gi|5031975 p21-activated kinase 4 isoform 1 [Homo sapiens]
          Length = 591

 Score =  522 bits (1344), Expect = e-148
 Identities = 291/464 (62%), Positives = 334/464 (71%), Gaps = 42/464 (9%)

Query: 265 DRRPKSSYLNQTSPQPTMR-QRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSE 323
           ++RPKSS      PQ + R +R  SG  +  P  P G ++      G  +N+Y       
Sbjct: 157 EKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQ-PAGLASGAKLAAGRPFNTY------- 208

Query: 324 PTMCIPKVDYDRAQMVLSPPLSGS-----DTYPRGPAK----LPQSQSKSGYSSSSHQYP 374
                P+ D D        P  G+     D  P GP+     +PQS      SSSS + P
Sbjct: 209 -----PRADTDH-------PSRGAQGEPHDVAPNGPSAGGLAIPQS------SSSSSRPP 250

Query: 375 SGYHKATLYHHPSLQSSSQYISTASYLS-SLSLSSSTYPPPSWGSSSDQQPSRVSHEQFR 433
           +    A     PS      + S       + + ++   P P    S  ++P RVSHEQFR
Sbjct: 251 TRARGA-----PSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFR 305

Query: 434 AALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFN 493
           AALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +GK VAVKKMDLRKQQRRELLFN
Sbjct: 306 AALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFN 365

Query: 494 EVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVL 553
           EVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIA VCL+VL
Sbjct: 366 EVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVL 425

Query: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613
           +ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCAQVSKEVP+RKSLVGTPYWMAPE
Sbjct: 426 QALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPE 485

Query: 614 VISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVL 673
           +ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+AM+ IRD+LPPR+K+LHKVS  L
Sbjct: 486 LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSL 545

Query: 674 RGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYR 717
           +GFLD +LVR+P+QRATA ELL HPFL  AGPP+ IVPLMRQ R
Sbjct: 546 KGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR 589



 Score =  160 bits (405), Expect = 4e-39
 Identities = 73/116 (62%), Positives = 94/116 (81%)

Query: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
           MFGK+KK++EIS PSNFEHRVHTGFD  EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60

Query: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
            IQ    KTIVRG+K  K+ ++  LL++F+N+SVTRSNSLR++SPP P +    +G
Sbjct: 61  SIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENG 116


>gi|62422561 p21-activated kinase 4 isoform 2 [Homo sapiens]
          Length = 438

 Score =  511 bits (1317), Expect = e-145
 Identities = 253/306 (82%), Positives = 276/306 (90%)

Query: 412 PPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHT 471
           P P    S  ++P RVSHEQFRAALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +
Sbjct: 131 PGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSS 190

Query: 472 GKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGAL 531
           GK VAVKKMDLRKQQRRELLFNEVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGAL
Sbjct: 191 GKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGAL 250

Query: 532 TDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCA 591
           TDIVTHTRMNEEQIA VCL+VL+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCA
Sbjct: 251 TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 310

Query: 592 QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQA 651
           QVSKEVP+RKSLVGTPYWMAPE+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+A
Sbjct: 311 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 370

Query: 652 MRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVP 711
           M+ IRD+LPPR+K+LHKVS  L+GFLD +LVR+P+QRATA ELL HPFL  AGPP+ IVP
Sbjct: 371 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 430

Query: 712 LMRQYR 717
           LMRQ R
Sbjct: 431 LMRQNR 436



 Score =  112 bits (280), Expect = 1e-24
 Identities = 60/116 (51%), Positives = 78/116 (67%), Gaps = 9/116 (7%)

Query: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
           MFGK+KK++EIS PSNFEHRVHTGFD  EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60

Query: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
            IQ    K      +P  + + NG       +++ +S+S     PPT  +GA S G
Sbjct: 61  SIQPGAPK-----GEP-HDVAPNG--PSAGGLAIPQSSS-SSSRPPTRARGAPSPG 107


>gi|62422563 p21-activated kinase 4 isoform 2 [Homo sapiens]
          Length = 438

 Score =  511 bits (1317), Expect = e-145
 Identities = 253/306 (82%), Positives = 276/306 (90%)

Query: 412 PPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHT 471
           P P    S  ++P RVSHEQFRAALQLVV PGDPR YL NFIKIGEGSTGIVCIAT + +
Sbjct: 131 PGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSS 190

Query: 472 GKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGAL 531
           GK VAVKKMDLRKQQRRELLFNEVVIMRDY H+NVV+MY+SYLVGDELWVVMEFLEGGAL
Sbjct: 191 GKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGAL 250

Query: 532 TDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCA 591
           TDIVTHTRMNEEQIA VCL+VL+ALS LH QGVIHRDIKSDSILLT DGR+KLSDFGFCA
Sbjct: 251 TDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCA 310

Query: 592 QVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQA 651
           QVSKEVP+RKSLVGTPYWMAPE+ISRLPYG EVDIWSLGIMVIEM+DGEPPYFNEPPL+A
Sbjct: 311 QVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKA 370

Query: 652 MRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVP 711
           M+ IRD+LPPR+K+LHKVS  L+GFLD +LVR+P+QRATA ELL HPFL  AGPP+ IVP
Sbjct: 371 MKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVP 430

Query: 712 LMRQYR 717
           LMRQ R
Sbjct: 431 LMRQNR 436



 Score =  112 bits (280), Expect = 1e-24
 Identities = 60/116 (51%), Positives = 78/116 (67%), Gaps = 9/116 (7%)

Query: 1   MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCIT 60
           MFGK+KK++EIS PSNFEHRVHTGFD  EQKFTGLP+QW SL+ ++A RPKP+VDP+CIT
Sbjct: 1   MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACIT 60

Query: 61  PIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHG 116
            IQ    K      +P  + + NG       +++ +S+S     PPT  +GA S G
Sbjct: 61  SIQPGAPK-----GEP-HDVAPNG--PSAGGLAIPQSSS-SSSRPPTRARGAPSPG 107


>gi|42794769 p21-activated kinase 1 isoform 2 [Homo sapiens]
          Length = 545

 Score =  317 bits (811), Expect = 3e-86
 Identities = 155/308 (50%), Positives = 225/308 (73%), Gaps = 2/308 (0%)

Query: 408 SSTYPPPSWGSSSDQQPSR--VSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCI 465
           ++T PP +   ++++Q  +  +S E+    L+ +VS GDP++    F KIG+G++G V  
Sbjct: 227 NNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYT 286

Query: 466 ATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEF 525
           A +  TG++VA+K+M+L++Q ++EL+ NE+++MR+  + N+V+   SYLVGDELWVVME+
Sbjct: 287 AMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 346

Query: 526 LEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLS 585
           L GG+LTD+VT T M+E QIA VC   L+AL +LH+  VIHRDIKSD+ILL  DG +KL+
Sbjct: 347 LAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLT 406

Query: 586 DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFN 645
           DFGFCAQ++ E  KR ++VGTPYWMAPEV++R  YG +VDIWSLGIM IEMI+GEPPY N
Sbjct: 407 DFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLN 466

Query: 646 EPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGP 705
           E PL+A+  I  +  P +++  K+S++ R FL+  L  +  +R +A+ELL H FLK+A P
Sbjct: 467 ENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKP 526

Query: 706 PSCIVPLM 713
            S + PL+
Sbjct: 527 LSSLTPLI 534



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)

Query: 4   KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
           K+K++ EIS PS+FEH +H GFD    +FTG+P+QW  LL  T+N  K
Sbjct: 68  KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLL-QTSNITK 114


>gi|189491759 p21-activated kinase 3 isoform d [Homo sapiens]
          Length = 559

 Score =  316 bits (809), Expect = 5e-86
 Identities = 152/292 (52%), Positives = 218/292 (74%)

Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
           ++ S+++ E+    L+ +VS GDP++    F KIG+G++G V  A +  TG++VA+K+M+
Sbjct: 256 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 315

Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
           L++Q ++EL+ NE+++MR+  + N+V+   SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 316 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 375

Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
           E QIA VC   L+AL +LH+  VIHRDIKSD+ILL  DG +KL+DFGFCAQ++ E  KR 
Sbjct: 376 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 435

Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
           ++VGTPYWMAPEV++R  YG +VDIWSLGIM IEM++GEPPY NE PL+A+  I  +  P
Sbjct: 436 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 495

Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
            +++  ++S+V R FL+  L  +  +R +A+ELL HPFLKLA P S + PL+
Sbjct: 496 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 547



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 25/63 (39%), Positives = 34/63 (53%), Gaps = 16/63 (25%)

Query: 4   KKKKKIEISGPSNFEHRVHTGFDPQEQKFT---------------GLPQQWHSLLADTAN 48
           K+K++ EIS PS+FEH +H GFD    +FT               G+P+QW  LL  T+N
Sbjct: 63  KEKERPEISLPSDFEHTIHVGFDAVTGEFTPDLYGSQMCPGKLPEGIPEQWARLL-QTSN 121

Query: 49  RPK 51
             K
Sbjct: 122 ITK 124


>gi|189491757 p21-activated kinase 3 isoform c [Homo sapiens]
          Length = 565

 Score =  316 bits (809), Expect = 5e-86
 Identities = 152/292 (52%), Positives = 218/292 (74%)

Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
           ++ S+++ E+    L+ +VS GDP++    F KIG+G++G V  A +  TG++VA+K+M+
Sbjct: 262 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 321

Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
           L++Q ++EL+ NE+++MR+  + N+V+   SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 322 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 381

Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
           E QIA VC   L+AL +LH+  VIHRDIKSD+ILL  DG +KL+DFGFCAQ++ E  KR 
Sbjct: 382 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 441

Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
           ++VGTPYWMAPEV++R  YG +VDIWSLGIM IEM++GEPPY NE PL+A+  I  +  P
Sbjct: 442 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 501

Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
            +++  ++S+V R FL+  L  +  +R +A+ELL HPFLKLA P S + PL+
Sbjct: 502 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 553



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 18/35 (51%), Positives = 24/35 (68%)

Query: 4  KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQ 38
          K+K++ EIS PS+FEH +H GFD    +FT  P Q
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQ 97


>gi|189491755 p21-activated kinase 3 isoform b [Homo sapiens]
          Length = 580

 Score =  316 bits (809), Expect = 5e-86
 Identities = 152/292 (52%), Positives = 218/292 (74%)

Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
           ++ S+++ E+    L+ +VS GDP++    F KIG+G++G V  A +  TG++VA+K+M+
Sbjct: 277 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 336

Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
           L++Q ++EL+ NE+++MR+  + N+V+   SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 337 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 396

Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
           E QIA VC   L+AL +LH+  VIHRDIKSD+ILL  DG +KL+DFGFCAQ++ E  KR 
Sbjct: 397 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 456

Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
           ++VGTPYWMAPEV++R  YG +VDIWSLGIM IEM++GEPPY NE PL+A+  I  +  P
Sbjct: 457 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 516

Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
            +++  ++S+V R FL+  L  +  +R +A+ELL HPFLKLA P S + PL+
Sbjct: 517 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 568



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 18/35 (51%), Positives = 24/35 (68%)

Query: 4  KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQ 38
          K+K++ EIS PS+FEH +H GFD    +FT  P Q
Sbjct: 63 KEKERPEISLPSDFEHTIHVGFDAVTGEFTNSPFQ 97


>gi|189491753 p21-activated kinase 3 isoform a [Homo sapiens]
          Length = 544

 Score =  316 bits (809), Expect = 5e-86
 Identities = 152/292 (52%), Positives = 218/292 (74%)

Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
           ++ S+++ E+    L+ +VS GDP++    F KIG+G++G V  A +  TG++VA+K+M+
Sbjct: 241 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 300

Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
           L++Q ++EL+ NE+++MR+  + N+V+   SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 301 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 360

Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
           E QIA VC   L+AL +LH+  VIHRDIKSD+ILL  DG +KL+DFGFCAQ++ E  KR 
Sbjct: 361 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 420

Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
           ++VGTPYWMAPEV++R  YG +VDIWSLGIM IEM++GEPPY NE PL+A+  I  +  P
Sbjct: 421 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 480

Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
            +++  ++S+V R FL+  L  +  +R +A+ELL HPFLKLA P S + PL+
Sbjct: 481 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)

Query: 4   KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
           K+K++ EIS PS+FEH +H GFD    +FTG+P+QW  LL  T+N  K
Sbjct: 63  KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLL-QTSNITK 109


>gi|189491751 p21-activated kinase 3 isoform a [Homo sapiens]
          Length = 544

 Score =  316 bits (809), Expect = 5e-86
 Identities = 152/292 (52%), Positives = 218/292 (74%)

Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
           ++ S+++ E+    L+ +VS GDP++    F KIG+G++G V  A +  TG++VA+K+M+
Sbjct: 241 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 300

Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
           L++Q ++EL+ NE+++MR+  + N+V+   SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 301 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 360

Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
           E QIA VC   L+AL +LH+  VIHRDIKSD+ILL  DG +KL+DFGFCAQ++ E  KR 
Sbjct: 361 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 420

Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
           ++VGTPYWMAPEV++R  YG +VDIWSLGIM IEM++GEPPY NE PL+A+  I  +  P
Sbjct: 421 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 480

Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
            +++  ++S+V R FL+  L  +  +R +A+ELL HPFLKLA P S + PL+
Sbjct: 481 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)

Query: 4   KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
           K+K++ EIS PS+FEH +H GFD    +FTG+P+QW  LL  T+N  K
Sbjct: 63  KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLL-QTSNITK 109


>gi|4505601 p21-activated kinase 3 isoform a [Homo sapiens]
          Length = 544

 Score =  316 bits (809), Expect = 5e-86
 Identities = 152/292 (52%), Positives = 218/292 (74%)

Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
           ++ S+++ E+    L+ +VS GDP++    F KIG+G++G V  A +  TG++VA+K+M+
Sbjct: 241 RKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMN 300

Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
           L++Q ++EL+ NE+++MR+  + N+V+   SYLVGDELWVVME+L GG+LTD+VT T M+
Sbjct: 301 LQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMD 360

Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
           E QIA VC   L+AL +LH+  VIHRDIKSD+ILL  DG +KL+DFGFCAQ++ E  KR 
Sbjct: 361 EGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRS 420

Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
           ++VGTPYWMAPEV++R  YG +VDIWSLGIM IEM++GEPPY NE PL+A+  I  +  P
Sbjct: 421 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 480

Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
            +++  ++S+V R FL+  L  +  +R +A+ELL HPFLKLA P S + PL+
Sbjct: 481 ELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLI 532



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)

Query: 4   KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
           K+K++ EIS PS+FEH +H GFD    +FTG+P+QW  LL  T+N  K
Sbjct: 63  KEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLL-QTSNITK 109


>gi|32483399 p21-activated kinase 2 [Homo sapiens]
          Length = 524

 Score =  307 bits (787), Expect = 2e-83
 Identities = 146/292 (50%), Positives = 216/292 (73%)

Query: 422 QQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMD 481
           ++ ++++ E+    L+ +VS GDP++    + KIG+G++G V  AT+   G++VA+K+++
Sbjct: 222 KKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQIN 281

Query: 482 LRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMN 541
           L+KQ ++EL+ NE+++M++  + N+V+   SYLVGDEL+VVME+L GG+LTD+VT T M+
Sbjct: 282 LQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMD 341

Query: 542 EEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRK 601
           E QIA VC   L+AL +LH   VIHRDIKSD++LL  +G +KL+DFGFCAQ++ E  KR 
Sbjct: 342 EAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRS 401

Query: 602 SLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPP 661
           ++VGTPYWMAPEV++R  YG +VDIWSLGIM IEM++GEPPY NE PL+A+  I  +  P
Sbjct: 402 TMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTP 461

Query: 662 RVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
            +++  K+S + R FL+  L  +  +R +A+ELL HPFLKLA P S + PL+
Sbjct: 462 ELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLI 513



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)

Query: 4   KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
           K+K++ EIS PS+FEH +H GFD    +FTG+P+QW  LL  T+N  K
Sbjct: 67  KEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLL-QTSNITK 113


>gi|190886457 p21-activated kinase 1 isoform 1 [Homo sapiens]
          Length = 553

 Score =  299 bits (766), Expect = 5e-81
 Identities = 146/290 (50%), Positives = 213/290 (73%), Gaps = 2/290 (0%)

Query: 408 SSTYPPPSWGSSSDQQPSR--VSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCI 465
           ++T PP +   ++++Q  +  +S E+    L+ +VS GDP++    F KIG+G++G V  
Sbjct: 227 NNTTPPDALTRNTEKQKKKPKMSDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYT 286

Query: 466 ATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEF 525
           A +  TG++VA+K+M+L++Q ++EL+ NE+++MR+  + N+V+   SYLVGDELWVVME+
Sbjct: 287 AMDVATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEY 346

Query: 526 LEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLS 585
           L GG+LTD+VT T M+E QIA VC   L+AL +LH+  VIHRDIKSD+ILL  DG +KL+
Sbjct: 347 LAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLT 406

Query: 586 DFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFN 645
           DFGFCAQ++ E  KR ++VGTPYWMAPEV++R  YG +VDIWSLGIM IEMI+GEPPY N
Sbjct: 407 DFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLN 466

Query: 646 EPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELL 695
           E PL+A+  I  +  P +++  K+S++ R FL+  L  +  +R +A+ELL
Sbjct: 467 ENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELL 516



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 25/48 (52%), Positives = 34/48 (70%), Gaps = 1/48 (2%)

Query: 4   KKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPK 51
           K+K++ EIS PS+FEH +H GFD    +FTG+P+QW  LL  T+N  K
Sbjct: 68  KEKERPEISLPSDFEHTIHVGFDAVTGEFTGMPEQWARLL-QTSNITK 114


>gi|103471999 serine/threonine kinase 3 [Homo sapiens]
          Length = 491

 Score =  201 bits (511), Expect = 2e-51
 Identities = 109/273 (39%), Positives = 161/273 (58%), Gaps = 4/273 (1%)

Query: 445 PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHD 504
           P E      K+GEGS G V  A  K +G+ VA+K++ +    +   +  E+ IM+     
Sbjct: 23  PEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPVESDLQE--IIKEISIMQQCDSP 80

Query: 505 NVVDMYSSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIATVCLSVLRALSYLHNQ 562
            VV  Y SY    +LW+VME+   G+++DI+   +  + E++IAT+  S L+ L YLH  
Sbjct: 81  YVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFM 140

Query: 563 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 622
             IHRDIK+ +ILL ++G  KL+DFG   Q++  + KR +++GTP+WMAPEVI  + Y  
Sbjct: 141 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 200

Query: 623 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV 682
             DIWSLGI  IEM +G+PPY +  P++A+  I  + PP  +     S     F+   LV
Sbjct: 201 VADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLV 260

Query: 683 REPSQRATAQELLGHPFLKLAGPPSCIVPLMRQ 715
           + P QRATA +LL HPF+K A P S +  L+ +
Sbjct: 261 KNPEQRATATQLLQHPFIKNAKPVSILRDLITE 293


>gi|5454096 serine/threonine kinase 4 [Homo sapiens]
          Length = 487

 Score =  201 bits (511), Expect = 2e-51
 Identities = 108/273 (39%), Positives = 161/273 (58%), Gaps = 4/273 (1%)

Query: 445 PREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHD 504
           P E      K+GEGS G V  A  K TG+ VA+K++ +    +   +  E+ IM+     
Sbjct: 26  PEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQE--IIKEISIMQQCDSP 83

Query: 505 NVVDMYSSYLVGDELWVVMEFLEGGALTDIVT--HTRMNEEQIATVCLSVLRALSYLHNQ 562
           +VV  Y SY    +LW+VME+   G+++DI+   +  + E++IAT+  S L+ L YLH  
Sbjct: 84  HVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFM 143

Query: 563 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 622
             IHRDIK+ +ILL ++G  KL+DFG   Q++  + KR +++GTP+WMAPEVI  + Y  
Sbjct: 144 RKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNC 203

Query: 623 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV 682
             DIWSLGI  IEM +G+PPY +  P++A+  I  + PP  +     S     F+   LV
Sbjct: 204 VADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLV 263

Query: 683 REPSQRATAQELLGHPFLKLAGPPSCIVPLMRQ 715
           + P QRATA +LL HPF++ A   S +  L+ +
Sbjct: 264 KSPEQRATATQLLQHPFVRSAKGVSILRDLINE 296


>gi|20070158 serine/threonine kinase 24 isoform a [Homo sapiens]
          Length = 443

 Score =  197 bits (500), Expect = 4e-50
 Identities = 112/304 (36%), Positives = 174/304 (57%), Gaps = 9/304 (2%)

Query: 416 WGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQV 475
           WG + +++ + + H      L+      DP E      KIG+GS G V    +  T K V
Sbjct: 8   WGLALNKRRATLPHPGGSTNLK-----ADPEELFTKLEKIGKGSFGEVFKGIDNRTQKVV 62

Query: 476 AVKKMDLRKQQRR-ELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDI 534
           A+K +DL + +   E +  E+ ++       V   Y SYL   +LW++ME+L GG+  D+
Sbjct: 63  AIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDL 122

Query: 535 VTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVS 594
           +    ++E QIAT+   +L+ L YLH++  IHRDIK+ ++LL+  G +KL+DFG   Q++
Sbjct: 123 LEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLT 182

Query: 595 KEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRR 654
               KR + VGTP+WMAPEVI +  Y ++ DIWSLGI  IE+  GEPP+    P++ +  
Sbjct: 183 DTQIKRNTFVGTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFL 242

Query: 655 IRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPF-LKLAGPPSCIVPLM 713
           I  + PP ++     S  L+ F++  L +EPS R TA+ELL H F L+ A   S +  L+
Sbjct: 243 IPKNNPPTLEG--NYSKPLKEFVEACLNKEPSFRPTAKELLKHKFILRNAKKTSYLTELI 300

Query: 714 RQYR 717
            +Y+
Sbjct: 301 DRYK 304


>gi|15451902 mitogen-activated protein kinase kinase kinase kinase 3
           [Homo sapiens]
          Length = 894

 Score =  196 bits (498), Expect = 6e-50
 Identities = 107/267 (40%), Positives = 165/267 (61%), Gaps = 6/267 (2%)

Query: 440 VSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMR 499
           +S  +P+E      +IG G+ G V  A   +TG+  A+K + L   +   ++  E+++M+
Sbjct: 7   LSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMK 66

Query: 500 DYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVLRALSY 558
           D  H N+V  + SYL  D+LW+ MEF  GG+L DI   T  ++E QIA V    L+ L Y
Sbjct: 67  DCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYY 126

Query: 559 LHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS-- 616
           LH++G +HRDIK  +ILLT +G +KL+DFG  AQ++  + KRKS +GTPYWMAPEV +  
Sbjct: 127 LHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVE 186

Query: 617 -RLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDS--LPPRVKDLHKVSSVL 673
            +  Y    D+W++GI  IE+ + +PP F+  P++A+  +  S   PP++KD  K S+  
Sbjct: 187 RKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSF 246

Query: 674 RGFLDLMLVREPSQRATAQELLGHPFL 700
             F+ + L + P +R TA++LL HPF+
Sbjct: 247 HHFVKMALTKNPKKRPTAEKLLQHPFV 273


>gi|110349738 serine/threonine kinase 24 isoform b [Homo sapiens]
          Length = 431

 Score =  196 bits (497), Expect = 8e-50
 Identities = 108/276 (39%), Positives = 163/276 (59%), Gaps = 4/276 (1%)

Query: 444 DPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR-ELLFNEVVIMRDYH 502
           DP E      KIG+GS G V    +  T K VA+K +DL + +   E +  E+ ++    
Sbjct: 19  DPEELFTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

Query: 503 HDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQ 562
              V   Y SYL   +LW++ME+L GG+  D++    ++E QIAT+   +L+ L YLH++
Sbjct: 79  SPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSE 138

Query: 563 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 622
             IHRDIK+ ++LL+  G +KL+DFG   Q++    KR + VGTP+WMAPEVI +  Y +
Sbjct: 139 KKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDS 198

Query: 623 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV 682
           + DIWSLGI  IE+  GEPP+    P++ +  I  + PP ++     S  L+ F++  L 
Sbjct: 199 KADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEG--NYSKPLKEFVEACLN 256

Query: 683 REPSQRATAQELLGHPF-LKLAGPPSCIVPLMRQYR 717
           +EPS R TA+ELL H F L+ A   S +  L+ +Y+
Sbjct: 257 KEPSFRPTAKELLKHKFILRNAKKTSYLTELIDRYK 292


>gi|22035600 mitogen-activated protein kinase kinase kinase kinase 2
           [Homo sapiens]
          Length = 820

 Score =  191 bits (486), Expect = 2e-48
 Identities = 112/285 (39%), Positives = 162/285 (56%), Gaps = 6/285 (2%)

Query: 435 ALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNE 494
           AL   VS  DPR+      ++G G+ G V  A +  T +  AVK + L        L  E
Sbjct: 2   ALLRDVSLQDPRDRFELLQRVGAGTYGDVYKARDTVTSELAAVKIVKLDPGDDISSLQQE 61

Query: 495 VVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVL 553
           + I+R+  H NVV    SYL  D LW+ MEF  GG+L +I   T  + E QIA VC   L
Sbjct: 62  ITILRECRHPNVVAYIGSYLRNDRLWICMEFCGGGSLQEIYHATGPLEERQIAYVCREAL 121

Query: 554 RALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPE 613
           + L +LH+QG IHRDIK  ++LLT  G +KL+DFG   +++  V KR+S +GTPYWMAPE
Sbjct: 122 KGLHHLHSQGKIHRDIKGANLLLTLQGDVKLADFGVSGELTASVAKRRSFIGTPYWMAPE 181

Query: 614 VIS---RLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDS--LPPRVKDLHK 668
           V +   +  Y    D+W+LGI  IE+ + +PP F+  P++A+  +  S   PP+++D  +
Sbjct: 182 VAAVERKGGYNELCDVWALGITAIELGELQPPLFHLHPMRALMLMSKSSFQPPKLRDKTR 241

Query: 669 VSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLM 713
            +     FL L L + P +R TA++LL HPF     P + +  L+
Sbjct: 242 WTQNFHHFLKLALTKNPKKRPTAEKLLQHPFTTQQLPRALLTQLL 286


>gi|38570135 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  191 bits (484), Expect = 3e-48
 Identities = 104/257 (40%), Positives = 155/257 (60%), Gaps = 6/257 (2%)

Query: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSY 513
           ++G G+ G V  A   HTG+  AVK + L       L+  E+ ++++  H N+V  + SY
Sbjct: 25  RVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSY 84

Query: 514 LVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSD 572
           L  ++LW+ ME+  GG+L DI   T  ++E QIA VC   L+ L+YLH +G +HRDIK  
Sbjct: 85  LSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGA 144

Query: 573 SILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS---RLPYGTEVDIWSL 629
           +ILLT  G +KL+DFG  A+++  + KRKS +GTPYWMAPEV +      Y    DIW++
Sbjct: 145 NILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAV 204

Query: 630 GIMVIEMIDGEPPYFNEPPLQAMRRIRDS--LPPRVKDLHKVSSVLRGFLDLMLVREPSQ 687
           GI  IE+ + +PP F+  P++A+  +  S   PP++KD  K SS    F+ + L + P +
Sbjct: 205 GITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKK 264

Query: 688 RATAQELLGHPFLKLAG 704
           R TA+ LL H F+   G
Sbjct: 265 RPTAERLLTHTFVAQPG 281


>gi|14589909 mitogen-activated protein kinase kinase kinase kinase 5
           [Homo sapiens]
          Length = 846

 Score =  191 bits (484), Expect = 3e-48
 Identities = 104/257 (40%), Positives = 155/257 (60%), Gaps = 6/257 (2%)

Query: 454 KIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSY 513
           ++G G+ G V  A   HTG+  AVK + L       L+  E+ ++++  H N+V  + SY
Sbjct: 25  RVGSGTYGDVYKARNVHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFGSY 84

Query: 514 LVGDELWVVMEFLEGGALTDIVTHTR-MNEEQIATVCLSVLRALSYLHNQGVIHRDIKSD 572
           L  ++LW+ ME+  GG+L DI   T  ++E QIA VC   L+ L+YLH +G +HRDIK  
Sbjct: 85  LSREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLAYLHTKGKMHRDIKGA 144

Query: 573 SILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS---RLPYGTEVDIWSL 629
           +ILLT  G +KL+DFG  A+++  + KRKS +GTPYWMAPEV +      Y    DIW++
Sbjct: 145 NILLTDHGDVKLADFGVAAKITATIAKRKSFIGTPYWMAPEVAAVEKNGGYNQLCDIWAV 204

Query: 630 GIMVIEMIDGEPPYFNEPPLQAMRRIRDS--LPPRVKDLHKVSSVLRGFLDLMLVREPSQ 687
           GI  IE+ + +PP F+  P++A+  +  S   PP++KD  K SS    F+ + L + P +
Sbjct: 205 GITAIELGELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSSTFHNFVKIALTKNPKK 264

Query: 688 RATAQELLGHPFLKLAG 704
           R TA+ LL H F+   G
Sbjct: 265 RPTAERLLTHTFVAQPG 281


>gi|15011880 serine/threonine protein kinase MST4 isoform 1 [Homo
           sapiens]
          Length = 416

 Score =  189 bits (479), Expect = 1e-47
 Identities = 100/258 (38%), Positives = 153/258 (59%), Gaps = 3/258 (1%)

Query: 444 DPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR-ELLFNEVVIMRDYH 502
           DP E      +IG+GS G V    +  T + VA+K +DL + +   E +  E+ ++    
Sbjct: 19  DPEELFTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 78

Query: 503 HDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQ 562
              V   Y SYL G +LW++ME+L GG+  D++     +E QIAT+   +L+ L YLH++
Sbjct: 79  SSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSE 138

Query: 563 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 622
             IHRDIK+ ++LL+  G +KL+DFG   Q++    KR + VGTP+WMAPEVI +  Y +
Sbjct: 139 KKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIQQSAYDS 198

Query: 623 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV 682
           + DIWSLGI  IE+  GEPP  +  P++ +  I  + PP +  +   +   + F+D  L 
Sbjct: 199 KADIWSLGITAIELAKGEPPNSDMHPMRVLFLIPKNNPPTL--VGDFTKSFKEFIDACLN 256

Query: 683 REPSQRATAQELLGHPFL 700
           ++PS R TA+ELL H F+
Sbjct: 257 KDPSFRPTAKELLKHKFI 274


>gi|21361358 serine/threonine kinase 25 [Homo sapiens]
          Length = 426

 Score =  186 bits (472), Expect = 7e-47
 Identities = 100/276 (36%), Positives = 159/276 (57%), Gaps = 4/276 (1%)

Query: 444 DPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRR-ELLFNEVVIMRDYH 502
           DP E      +IG+GS G V    + HT + VA+K +DL + +   E +  E+ ++    
Sbjct: 15  DPEELFTKLDRIGKGSFGEVYKGIDNHTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCD 74

Query: 503 HDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQ 562
              +   + SYL   +LW++ME+L GG+  D++    + E  IAT+   +L+ L YLH++
Sbjct: 75  SPYITRYFGSYLKSTKLWIIMEYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSE 134

Query: 563 GVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGT 622
             IHRDIK+ ++LL+  G +KL+DFG   Q++    KR + VGTP+WMAPEVI +  Y  
Sbjct: 135 RKIHRDIKAANVLLSEQGDVKLADFGVAGQLTDTQIKRNTFVGTPFWMAPEVIKQSAYDF 194

Query: 623 EVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLV 682
           + DIWSLGI  IE+  GEPP  +  P++ +  I  + PP ++  H  S   + F++  L 
Sbjct: 195 KADIWSLGITAIELAKGEPPNSDLHPMRVLFLIPKNSPPTLEGQH--SKPFKEFVEACLN 252

Query: 683 REPSQRATAQELLGHPFL-KLAGPPSCIVPLMRQYR 717
           ++P  R TA+ELL H F+ +     S +  L+ +Y+
Sbjct: 253 KDPRFRPTAKELLKHKFITRYTKKTSFLTELIDRYK 288


>gi|239735592 TRAF2 and NCK interacting kinase isoform 8 [Homo
           sapiens]
          Length = 1268

 Score =  185 bits (470), Expect = 1e-46
 Identities = 101/262 (38%), Positives = 156/262 (59%), Gaps = 17/262 (6%)

Query: 455 IGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDY-HHDNVVDMYSSY 513
           +G G+ G V       TG+  A+K MD+   +  E+   E+ +++ Y HH N+   Y ++
Sbjct: 31  VGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIK-QEINMLKKYSHHRNIATYYGAF 89

Query: 514 L------VGDELWVVMEFLEGGALTDIVTHTRMN---EEQIATVCLSVLRALSYLHNQGV 564
           +      + D+LW+VMEF   G++TD++ +T+ N   EE IA +C  +LR LS+LH   V
Sbjct: 90  IKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKV 149

Query: 565 IHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS-----RLP 619
           IHRDIK  ++LLT +  +KL DFG  AQ+ + V +R + +GTPYWMAPEVI+        
Sbjct: 150 IHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDAT 209

Query: 620 YGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDL 679
           Y  + D+WSLGI  IEM +G PP  +  P++A+  I  +  PR+K   K S   + F++ 
Sbjct: 210 YDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKS-KKWSKKFQSFIES 268

Query: 680 MLVREPSQRATAQELLGHPFLK 701
            LV+  SQR   ++L+ HPF++
Sbjct: 269 CLVKNHSQRPATEQLMKHPFIR 290


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.131    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,083,656
Number of Sequences: 37866
Number of extensions: 1513917
Number of successful extensions: 6352
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 712
Number of HSP's successfully gapped in prelim test: 164
Number of HSP's that attempted gapping in prelim test: 3758
Number of HSP's gapped (non-prelim): 1260
length of query: 719
length of database: 18,247,518
effective HSP length: 110
effective length of query: 609
effective length of database: 14,082,258
effective search space: 8576095122
effective search space used: 8576095122
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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