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Search of human proteins with 24308181
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|24308181 kelch-like 9 [Homo sapiens]
(617 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|24308181 kelch-like 9 [Homo sapiens] 1268 0.0
gi|45643138 kelch-like 13 [Homo sapiens] 1181 0.0
gi|8922854 kelch-like 26 [Homo sapiens] 465 e-131
gi|31542246 kelch-like 36 [Homo sapiens] 425 e-119
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 383 e-106
gi|55741643 kelch-like 14 [Homo sapiens] 355 7e-98
gi|156616301 kelch-like 32 [Homo sapiens] 345 9e-95
gi|24432026 kelch-like [Homo sapiens] 338 1e-92
gi|226442729 kelch-like 15 [Homo sapiens] 311 1e-84
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 300 3e-81
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 300 3e-81
gi|40807500 kelch-like 20 [Homo sapiens] 283 3e-76
gi|23397572 kelch-like 34 [Homo sapiens] 280 4e-75
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 279 5e-75
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 269 5e-72
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 268 8e-72
gi|55925604 kelch-like 18 [Homo sapiens] 267 2e-71
gi|14780904 kelch-like 1 protein [Homo sapiens] 264 2e-70
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 261 1e-69
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 260 3e-69
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 260 3e-69
gi|166235129 kelch-like 3 [Homo sapiens] 259 7e-69
gi|38194229 kelch-like 17 [Homo sapiens] 258 1e-68
gi|11056006 kelch-like 12 [Homo sapiens] 250 3e-66
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 241 1e-63
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 241 1e-63
gi|148664209 kelch-like 10 [Homo sapiens] 237 3e-62
gi|40018614 DRE1 protein [Homo sapiens] 224 1e-58
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 221 2e-57
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 219 4e-57
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 1268 bits (3280), Expect = 0.0
Identities = 617/617 (100%), Positives = 617/617 (100%)
Query: 1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD 60
MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD
Sbjct: 1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD 60
Query: 61 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD 120
EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD
Sbjct: 61 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD 120
Query: 121 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN 180
NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN
Sbjct: 121 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN 180
Query: 181 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI 240
FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI
Sbjct: 181 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI 240
Query: 241 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL 300
RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL
Sbjct: 241 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL 300
Query: 301 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 360
VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT
Sbjct: 301 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 360
Query: 361 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN 420
KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN
Sbjct: 361 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN 420
Query: 421 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT 480
PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT
Sbjct: 421 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT 480
Query: 481 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV 540
TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV
Sbjct: 481 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV 540
Query: 541 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN 600
AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN
Sbjct: 541 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN 600
Query: 601 PGSPSRESPLSAPSDHS 617
PGSPSRESPLSAPSDHS
Sbjct: 601 PGSPSRESPLSAPSDHS 617
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 1181 bits (3056), Expect = 0.0
Identities = 569/613 (92%), Positives = 594/613 (96%)
Query: 1 MKVSLGNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGD 60
MK+SLG EMG+S+HLQ KAG TR FTSNTHSSVVLQGFDQLR+EGLLCDVTL+PGD D
Sbjct: 43 MKLSLGGSEMGLSSHLQSSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTD 102
Query: 61 EIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMD 120
+ FPVHR MMASASDYFKAMFTGGMKEQDLMCIKLHGV+KVGL+KIIDFIYTAKLSLNMD
Sbjct: 103 DAFPVHRVMMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMD 162
Query: 121 NLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKN 180
NLQDTLEAASFLQILPVLDFCKVFLISGV+LDNCVEVGRIANTYNL EVDKYVN+F+LKN
Sbjct: 163 NLQDTLEAASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKN 222
Query: 181 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNI 240
FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKA CRWLRLE+PRMD+AAKLMKNI
Sbjct: 223 FPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNI 282
Query: 241 RFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHL 300
RFPLMTPQ+LINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSD+THL
Sbjct: 283 RFPLMTPQELINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHL 342
Query: 301 VTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 360
VTLGGVLRQQLVVSKELRMYDE+A EW+SLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT
Sbjct: 343 VTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDT 402
Query: 361 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYN 420
KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKG+LYAVGGR+AAGEL TVECYN
Sbjct: 403 KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYN 462
Query: 421 PRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMT 480
PR NEW+YVAKMSEPHYGHAGTVYGG+MYISGGITHDTFQ ELMCFDPDTDKW+QKAPMT
Sbjct: 463 PRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMT 522
Query: 481 TVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV 540
TVRGLHCMCTVG++LYVIGGNHFRGTSDYDDVLSCEYYSP LDQWTPIAAMLRGQSDVGV
Sbjct: 523 TVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582
Query: 541 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN 600
AVFENKIYVVGGYSWNNRCMVEIVQKYDP+KDEWHKVFDLPESLGGIRACTLTVFPPEE
Sbjct: 583 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGIRACTLTVFPPEET 642
Query: 601 PGSPSRESPLSAP 613
SPSRESPLSAP
Sbjct: 643 TPSPSRESPLSAP 655
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 465 bits (1196), Expect = e-131
Identities = 245/574 (42%), Positives = 353/574 (61%), Gaps = 8/574 (1%)
Query: 27 FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMK 86
F++ +HS+ +LQG LR +G L DV L E FP H+ ++A+ SDYF+AMFTGGM+
Sbjct: 40 FSAPSHSTSLLQGLATLRAQGQLLDVVLTINR--EAFPAHKVVLAACSDYFRAMFTGGMR 97
Query: 87 EQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 146
E I+L GV+ GL+ IIDF Y+A+++L++D +QD L AA FLQ+LPV++ C+ FL
Sbjct: 98 EASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLK 157
Query: 147 SGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNS 206
+ +S++ C+ +G++A T++L + + V+ F ++F + +FL+LP ERL F L SN
Sbjct: 158 AAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNR 217
Query: 207 LKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTC 266
L+ C E++LF+AA RWL+ + R A+ ++ +IRFPLM +L++ VQT+D M D C
Sbjct: 218 LQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLC 277
Query: 267 VNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVL---RQQLVVSKELRMYDER 323
LLEA NYQ++P+ Q MQS RTA+RSD LVT GG + V SK ++ +
Sbjct: 278 RQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPG 337
Query: 324 AQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVA 383
A+ +R L M+ +AV+ NF+YV GGQ G+ AVD +R+DP N+W+++
Sbjct: 338 ARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQ 397
Query: 384 SLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTV 443
++ E R F L+ L G +YA GGR+ AG LA+VE Y PR NEW Y + +GHAG
Sbjct: 398 AMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGAA 457
Query: 444 YGGLMYISGGITHDTFQNE-LMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNH 502
GG +YISGG + L C+DP D+W KAPM+ R LH M G ++Y +GG
Sbjct: 458 SGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGRM 517
Query: 503 FRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVE 562
+ DVL+ EYY P DQWT ++ M GQS+ G + E KIY+VGGY+W +
Sbjct: 518 DHVDRCF-DVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYNWRLNNVTG 576
Query: 563 IVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFP 596
IVQ Y+ + DEW + PES GI AC + P
Sbjct: 577 IVQVYNTDTDEWERDLHFPESFAGI-ACAPVLLP 609
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 425 bits (1092), Expect = e-119
Identities = 224/578 (38%), Positives = 353/578 (61%), Gaps = 13/578 (2%)
Query: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
HSS VLQ ++ R+ GL CDV LV + + P HR ++A SDYF +MFT GM+E
Sbjct: 28 HSSTVLQRLNEQRLRGLFCDVVLVADE--QRVPAHRNLLAVCSDYFNSMFTIGMREAFQK 85
Query: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
++L G + +GLK ++DF+Y +L L+ N+ LE A LQI V+DFC +L VS
Sbjct: 86 EVELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSE 145
Query: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLK-LPFERLAFVLSSNSLKHC 210
DN + + +A+ Y+L +D +++ FIL +F L T +FL+ + ++L LSS+ ++
Sbjct: 146 DNYLYLQELASIYSLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRE 205
Query: 211 TELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTV--DFMRTDNTCVN 268
E +L +AA +WL + R +A ++++NI FPL+ DL++ V+ + + C
Sbjct: 206 CEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEG 265
Query: 269 LLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQ-LVVSKELRMYDERAQEW 327
+ EA Y QPVMQ+ RTA+R++ L+ +GG + ++ L +S + D ++++W
Sbjct: 266 FIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQW 325
Query: 328 RSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNE 387
P+ A R H +AV+G F+++ GG + D G A + ++R+DPR +W++VAS+N+
Sbjct: 326 VKETPLPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQ 385
Query: 388 KRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGL 447
+R F+L++++ L A+GGR+ G L++VE Y+P+ + WSYVA + YGHAGT+Y
Sbjct: 386 RRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKDF 445
Query: 448 MYISGGITHD----TFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHF 503
+YISGG HD ++ L+C+D TD W ++ PMTT RG H MC++GD +Y IGG+
Sbjct: 446 VYISGG--HDYQIGPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDD 503
Query: 504 RGTS-DYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVE 562
S + DVL E YSP +QWT +A +L S+ GVAV+E +IY++GGYSW N +
Sbjct: 504 NIESMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSK 563
Query: 563 IVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEEN 600
VQ YD E D+W + DLP+++ G AC + P E+
Sbjct: 564 TVQVYDREADKWSRGVDLPKAIAGGSACVCALEPRPED 601
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 383 bits (983), Expect = e-106
Identities = 216/613 (35%), Positives = 335/613 (54%), Gaps = 28/613 (4%)
Query: 6 GNGEMGVSAHLQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPV 65
GNG +S+ L T ++ +L+G ++R E LCD LV G + F V
Sbjct: 40 GNGLSCISSEL-----------TDASYGPNLLEGLSKMRQENFLCD--LVIGTKTKSFDV 86
Query: 66 HRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDT 125
H+++MAS S+YF + K+ + + L+ ++ +GL +I + YT KL+L++ +
Sbjct: 87 HKSVMASCSEYFYNILK---KDPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSI 143
Query: 126 LEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALL 185
+ AA +LQI ++ C FLI +S++NC+ V IA TY+L FI NF
Sbjct: 144 ISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFA 203
Query: 186 STGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLM 245
+ +F+KL FE++ +L + L+ +E+ F+ A +WL + R+ YAA L+ NIRF +
Sbjct: 204 ESDQFMKLTFEQINELLIDDDLQLPSEIVAFQIAMKWLEFDQKRVKYAADLLSNIRFGTI 263
Query: 246 TPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGG 305
+ QDL+NYVQ+V M D C LL++A NY ++PY Q +QS RT IR LVT+GG
Sbjct: 264 SAQDLVNYVQSVPRMMQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRVLVTVGG 323
Query: 306 VLRQQLVVSKELR--MYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKG- 362
R L R +Y + W L M A + +AV+ FLYV GG+ D +
Sbjct: 324 --RPGLTEKSLSRDILYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQ 381
Query: 363 -KTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNP 421
K AV R+DPR+N W+ +AS+N+KRT F LS G +YA GGR+A G LA++ECY P
Sbjct: 382 AKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVP 441
Query: 422 RMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTT 481
N+W + HA V G + ++GG + + + +DP +D W + ++T
Sbjct: 442 STNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLST 501
Query: 482 VRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVA 541
RG HC T+ D++YV+GG+ + DVL+ E YSP QW+ A + G S GV+
Sbjct: 502 PRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVS 561
Query: 542 VFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENP 601
+ Y+VGG++ + + +Q + PE +EW + +LPE+ G+ CTL++ P
Sbjct: 562 ALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPEATVGVSCCTLSM------P 615
Query: 602 GSPSRESPLSAPS 614
+ +RES S+ S
Sbjct: 616 NNVTRESRASSVS 628
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 355 bits (911), Expect = 7e-98
Identities = 211/621 (33%), Positives = 326/621 (52%), Gaps = 68/621 (10%)
Query: 31 THSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFT------GG 84
+HS +L G + L + L CDVTL G + F H+A++AS S YF+++F+ GG
Sbjct: 14 SHSDNLLHGLNLLWRKQLFCDVTLT-AQGQQ-FHCHKAVLASCSQYFRSLFSSHPPLGGG 71
Query: 85 MKEQD---------------------------------------------LMCIKLHGVN 99
+ QD + + L G +
Sbjct: 72 VGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAINNLVLQGCS 131
Query: 100 KVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGR 159
+GL+ +++++YTA ++L++D +++ L + L I V C FL +S+ N +V +
Sbjct: 132 SIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQNYKQVCK 191
Query: 160 IANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAA 219
IA + L E K N ++++ + L L FE + +L S +EL LF+ +
Sbjct: 192 IAALHGLEETKKLANKYLVE---------DVLLLNFEEMRALLDSLPPPVESELALFQMS 242
Query: 220 CRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQM 278
WL + + RM YA LMK +RF L+ +L+ VQ+VDFMRTD C LLL+A NY +
Sbjct: 243 VLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQKLLLDAMNYHL 302
Query: 279 MPYMQPVMQSDRTAIRSDSTHLVTLGGVLR-QQLVVSKELRMYDERAQEWRSLAPMDAPR 337
MP+ Q QS + IRS+ L+ +GG+ + S ++ YD+ + W+ L M
Sbjct: 303 MPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNS 362
Query: 338 YQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL 397
H + + NFL+V+GG+ ++ GK + + V R+DPR+N W+Q+ + E+R F+ L
Sbjct: 363 AHHCVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFNSWIQLPPMQERRASFYACRL 422
Query: 398 KGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHD 457
HLY +GGR+ G L++VECYN NEW YV+ + +P HAG V+ G +YISGG+ +
Sbjct: 423 DKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHNGKIYISGGVHNG 482
Query: 458 TFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEY 517
+ L C+DP D W +K M T R +H + + D+LY IGGNH +G S + DV+ E
Sbjct: 483 EYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFS-HLDVMLVEC 541
Query: 518 YSPTLDQWTPI-AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHK 576
Y P DQW + +L G+S G AV ++ IY+VGGYSW+ Y PEK W +
Sbjct: 542 YDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSWSMGAYKSSTICYCPEKGTWTE 601
Query: 577 V-FDLPESLGGIRACTLTVFP 596
+ D+ E L G AC + P
Sbjct: 602 LEGDVAEPLAG-PACVTVILP 621
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 345 bits (884), Expect = 9e-95
Identities = 217/586 (37%), Positives = 326/586 (55%), Gaps = 23/586 (3%)
Query: 25 RFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGG 84
R S +H+ VL +Q R +G+LCD+TL+ + + F H+A++A+ SDYF+AMF+
Sbjct: 17 RLCHSESHNDSVLAALNQQRSDGILCDITLIAEE--QKFHAHKAVLAACSDYFRAMFSLC 74
Query: 85 MKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 144
M E + LHGV +GLK+ ++F YT ++ L +QD L A S LQ+L +L+ C +
Sbjct: 75 MVESGADEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHY 134
Query: 145 LISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLST--GEFLKLPFERLAFVL 202
LI ++ N +++ R+A+ +NL ++K V +F++K+ LL + E L LP+ L VL
Sbjct: 135 LIQELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVL 194
Query: 203 SSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRT 262
S+ L +E ++++ A RWL + Y +L++ IRF LM L + ++
Sbjct: 195 KSDRLTSLSEEQIWQLAVRWLE-HNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQA 253
Query: 263 DNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDE 322
T L+ EA Y Y QPV Q+ RT R S L +GG R+ V KELR ++
Sbjct: 254 SETATALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKV-KELRYFNP 312
Query: 323 RAQE---------WRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 373
QE W LAPM R H +AV+G+FL+V GG+ + + AV T R+D
Sbjct: 313 VDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYD 372
Query: 374 PRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGE-LATVECYNPRMNEWSYVAKM 432
PR N W ++A + R F L A++ +LYAVGGR+ + L TVE Y P+ N+W++V
Sbjct: 373 PRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSF 432
Query: 433 SEPHYGHAGTVYGGLMYISGGITHDT-FQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTV 491
HAG V GL++ISGG+T+ +QN LM ++P+ +KW+ ++PM R H M V
Sbjct: 433 DRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 492
Query: 492 GDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPI-AAMLRGQSDVGVAVFENKIYVV 550
KLYV+GGN +D V + Y+ DQWT +L GQ++ GVAV +IY+V
Sbjct: 493 QRKLYVLGGNDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVHNGRIYLV 552
Query: 551 GGYS-WNNRCMVEIVQKYDPEKDEWHKVF---DLPESLGGIRACTL 592
GGYS W N + +Q D ++ +VF LP + GI AC L
Sbjct: 553 GGYSIWTNEPLA-CIQVLDVSREGKEEVFYGPTLPFASNGIAACFL 597
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 338 bits (866), Expect = 1e-92
Identities = 208/597 (34%), Positives = 325/597 (54%), Gaps = 19/597 (3%)
Query: 27 FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMK 86
+ S HS +L+G LR G+L DV LV +G I HR ++A++ DYF+ MF GG+K
Sbjct: 27 YRSAQHSQALLRGLLALRDSGILFDVVLVV-EGRHI-EAHRILLAASCDYFRGMFAGGLK 84
Query: 87 EQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 146
E + + +HGV+ + +I+ FIYT++L L++ N+Q+TL AA LQI ++ FC FL+
Sbjct: 85 EMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLM 144
Query: 147 SGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNS 206
S V +N ++V R+A ++L + + ++ +ILKNF A T ++ +LP E++ +LSSN
Sbjct: 145 SWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSLLSSNR 204
Query: 207 LKHCTELELFKAACRW-LRLEDPRMDYAA-----KLMKNIRFPLMTPQDLINYVQTVDFM 260
L+ E E+++ A + LE + D + KL++ +RFPLM + L +D
Sbjct: 205 LEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPS 264
Query: 261 RTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGV-LRQQLVVSKELRM 319
+T + L+ Y +QP +QS +T +RSD +V GG+ V+S + +
Sbjct: 265 PLRDTVASALM----YHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQAKY 320
Query: 320 YDERAQEWRSLAPMDAPRYQH-GIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 378
+ EW+ APR + GIAV+ NF+Y++GG +N +G A +R+DPR+N+
Sbjct: 321 LNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNN--VQGFRAESRCWRYDPRHNR 378
Query: 379 WMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYG 438
W Q+ SL ++ + + ++YAV GR +L VE Y+P N W+YVA + Y
Sbjct: 379 WFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVYA 438
Query: 439 HAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVI 498
HAG G MYI+ G + + E C+DP ++ W A R H M T+ +KLYVI
Sbjct: 439 HAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLYVI 498
Query: 499 GGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNR 558
GG++ DV YS T QW+ + + G + G+AV +N+IYV+GG S N
Sbjct: 499 GGSN-NDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRG 557
Query: 559 CMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGSPSRESPLSAPSD 615
V YD EKD W + L S+ G+ AC LT+ P P R +P + +D
Sbjct: 558 SRTGYVHIYDVEKDCWEEGPQLDNSISGLAACVLTL--PRSLLLEPPRGTPDRSQAD 612
>gi|226442729 kelch-like 15 [Homo sapiens]
Length = 604
Score = 311 bits (796), Expect = 1e-84
Identities = 191/594 (32%), Positives = 309/594 (52%), Gaps = 27/594 (4%)
Query: 21 AGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAM 80
AG F S+ H + V GF L EGLL DVTLV D F H+A++A+ SDYF+ M
Sbjct: 2 AGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQ--FQAHKALLATQSDYFRIM 59
Query: 81 FTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDF 140
FT M+E+D I L G+ G ++ F+Y + L+M+ + + L+AA ++Q++ V+ F
Sbjct: 60 FTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKF 119
Query: 141 CKVFLISGVSLDNCVEVGRIANTY--NLIEVDKYVNNFILKNFPALLSTGEFLK-LPFER 197
C FL++ + L+NC E+ R+ + + N+ V + ++ F+L NF L+S +FL L FE+
Sbjct: 120 CCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEK 179
Query: 198 LAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTV 257
L L ++ L E+EL++A WLR + R + +++NIRF LMTP + V+T
Sbjct: 180 LMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTS 239
Query: 258 DFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKEL 317
+F R + +A NY + QP++ + IRS G++ +V SK L
Sbjct: 240 EFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKIL 299
Query: 318 RMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYN 377
+ ++ + W L P +A++ NF++++GG+ A VFR+DPR N
Sbjct: 300 LL--KKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQN 357
Query: 378 KWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHY 437
W+Q+A ++ R+ F + + +YAV GR+ + E Y+ ++W +V Y
Sbjct: 358 SWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKY 417
Query: 438 GHAGTVYGGLMYISGGITHDTFQNELMCFDPD---------------TDKWMQKAPMTTV 482
GH GTV ++I+GGIT + ++ FDP T+ W K+ M
Sbjct: 418 GHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYA 477
Query: 483 RGLHCMCTVGDKLYVIGG--NHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV 540
R H M + KLYV GG R + + S E Y+P DQWT +A+M G+S GV
Sbjct: 478 RCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGV 537
Query: 541 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW--HKVFDLPESLGGIRACTL 592
V + +I V+GG +N I+ +DP++++W + +P L G++ C L
Sbjct: 538 TVLDKQIMVLGGLCYNGHYSDSIL-TFDPDENKWKEDEYPRMPCKLDGLQVCNL 590
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 300 bits (767), Expect = 3e-81
Identities = 191/583 (32%), Positives = 298/583 (51%), Gaps = 21/583 (3%)
Query: 16 LQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASD 75
++PC + FF + H+ + + LCDV LV GD P HR +++S SD
Sbjct: 142 MEPCTSD--EFFQALNHAEQTFKKMENYLRHKQLCDVILVAGD--RRIPAHRLVLSSVSD 197
Query: 76 YFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQIL 135
YF AMFT ++E IK+ GV L +I + YT +L L DN++ L A LQ+
Sbjct: 198 YFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLS 257
Query: 136 PVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPF 195
V++ C FL+ + NC+ + A+ ++ K +N+ +++F ++ EF+ LP
Sbjct: 258 QVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPA 317
Query: 196 ERLAFVLSSNSLKHCTELELFKAACRWLR--LEDPRMDYAAKLMKNIRFPLMTPQDLINY 253
+A +L+S+ + E + A W+R LE R D +KL+ IR PL+ PQ L +
Sbjct: 318 SEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD-LSKLLAYIRLPLLAPQFLADM 376
Query: 254 VQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTLGGVLRQQLV 312
V F R D C L++EA Y ++P +P++QS RT R + L +GG+ +
Sbjct: 377 ENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGA 435
Query: 313 VSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRF 372
S + YD R W +A M+ R Q G+AV+ + LYVVGG+ G ++TV +
Sbjct: 436 TS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-----GLKTLNTVECY 488
Query: 373 DPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKM 432
+P+ W + ++ R ++ L+G +YAVGG L TVE ++P+ +W++VA M
Sbjct: 489 NPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATM 548
Query: 433 SEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVG 492
S P V G +Y GG + + CFDP T+KW A M+ RG + T
Sbjct: 549 STPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 608
Query: 493 DKLYVIGGNHFRGTSDYDDVLSC-EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVG 551
LY IGG+ ++ + C E Y P D WT +A+M + VGV + +K+Y VG
Sbjct: 609 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 668
Query: 552 GYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTV 594
GY + + + V+ YDP+ +EW +V P LG AC +TV
Sbjct: 669 GY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGACVVTV 707
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 300 bits (767), Expect = 3e-81
Identities = 191/583 (32%), Positives = 298/583 (51%), Gaps = 21/583 (3%)
Query: 16 LQPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASD 75
++PC + FF + H+ + + LCDV LV GD P HR +++S SD
Sbjct: 188 MEPCTSD--EFFQALNHAEQTFKKMENYLRHKQLCDVILVAGD--RRIPAHRLVLSSVSD 243
Query: 76 YFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQIL 135
YF AMFT ++E IK+ GV L +I + YT +L L DN++ L A LQ+
Sbjct: 244 YFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLS 303
Query: 136 PVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPF 195
V++ C FL+ + NC+ + A+ ++ K +N+ +++F ++ EF+ LP
Sbjct: 304 QVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPA 363
Query: 196 ERLAFVLSSNSLKHCTELELFKAACRWLR--LEDPRMDYAAKLMKNIRFPLMTPQDLINY 253
+A +L+S+ + E + A W+R LE R D +KL+ IR PL+ PQ L +
Sbjct: 364 SEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD-LSKLLAYIRLPLLAPQFLADM 422
Query: 254 VQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTLGGVLRQQLV 312
V F R D C L++EA Y ++P +P++QS RT R + L +GG+ +
Sbjct: 423 ENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGA 481
Query: 313 VSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRF 372
S + YD R W +A M+ R Q G+AV+ + LYVVGG+ G ++TV +
Sbjct: 482 TS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-----GLKTLNTVECY 534
Query: 373 DPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKM 432
+P+ W + ++ R ++ L+G +YAVGG L TVE ++P+ +W++VA M
Sbjct: 535 NPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATM 594
Query: 433 SEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVG 492
S P V G +Y GG + + CFDP T+KW A M+ RG + T
Sbjct: 595 STPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWN 654
Query: 493 DKLYVIGGNHFRGTSDYDDVLSC-EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVG 551
LY IGG+ ++ + C E Y P D WT +A+M + VGV + +K+Y VG
Sbjct: 655 GLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVG 714
Query: 552 GYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTV 594
GY + + + V+ YDP+ +EW +V P LG AC +TV
Sbjct: 715 GY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGACVVTV 753
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 283 bits (725), Expect = 3e-76
Identities = 174/554 (31%), Positives = 296/554 (53%), Gaps = 23/554 (4%)
Query: 27 FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMK 86
+ S+ H L+ + LR LCDV LV G +I+ HR ++++ S YF+AMFTG +
Sbjct: 45 YISDKHPRQTLEVINLLRKHRELCDVVLVVG-AKKIY-AHRVILSACSPYFRAMFTGELA 102
Query: 87 EQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 146
E + + +++ ++ +IDF YT+++++ N+Q L AA LQ+ + + C FL
Sbjct: 103 ESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLK 162
Query: 147 SGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNS 206
+ NC+ + A+T++ E+ + + F NF ++ + EF+ LP +L ++SS+
Sbjct: 163 RQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDE 222
Query: 207 LKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNT 265
L +E ++F A W++ R ++++++R PL++P+ L+ V + +++D
Sbjct: 223 LNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEE 282
Query: 266 CVNLLLEASNYQMMPYMQPVMQSDRTAIRSD---STHLVTLGGVLRQQLVVSKELRMYDE 322
C +L+ EA NY ++P +P+MQ RT R L +GG + S E YD
Sbjct: 283 CRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVE--RYDP 340
Query: 323 RAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW-MQ 381
+ EWR +A M R G++V+ + LY VGG G + +++V R+DP+ N+W
Sbjct: 341 QTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD-----GSSYLNSVERYDPKTNQWSSD 395
Query: 382 VASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAG 441
VA + RT ++ L G LYAVGG+ L VE Y+P+ N+W+ VA MS G A
Sbjct: 396 VAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAV 455
Query: 442 TVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTV-GDKLYVIGG 500
V GG +Y GG + N + ++P ++W APM T R H C V D +Y +GG
Sbjct: 456 AVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGT-RRKHLGCAVYQDMIYAVGG 514
Query: 501 NHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCM 560
D ++ S E Y+P +QW+P+ AM +S VG+AV ++ VGG+ +
Sbjct: 515 R-----DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGF--DGTTY 567
Query: 561 VEIVQKYDPEKDEW 574
++ ++ +DP+ + W
Sbjct: 568 LKTIEVFDPDANTW 581
Score = 99.0 bits (245), Expect = 1e-20
Identities = 59/182 (32%), Positives = 95/182 (52%), Gaps = 16/182 (8%)
Query: 401 LYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQ 460
L+AVGG + +++VE Y+P+ NEW VA MS+ G +V L+Y GG ++
Sbjct: 320 LFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYL 379
Query: 461 NELMCFDPDTDKWMQK-APMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSC---- 515
N + +DP T++W AP +T R + +G LY +GG D +SC
Sbjct: 380 NSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQ---------DGVSCLNIV 430
Query: 516 EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWH 575
E Y P ++WT +A+M + V VAV +Y VGG + + V++Y+P+++ WH
Sbjct: 431 ERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP--LNTVERYNPQENRWH 488
Query: 576 KV 577
+
Sbjct: 489 TI 490
Score = 71.2 bits (173), Expect = 3e-12
Identities = 40/137 (29%), Positives = 66/137 (48%), Gaps = 22/137 (16%)
Query: 320 YDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 379
Y+ + W ++APM R G AV + +Y VGG+ + T + + R++PR N+W
Sbjct: 480 YNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD-----TTELSSAERYNPRTNQW 534
Query: 380 MQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGH 439
V ++ +R+ L+ + G L AVGG L T+E ++P N W
Sbjct: 535 SPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW------------- 581
Query: 440 AGTVYGGLMY--ISGGI 454
+YGG+ Y + GG+
Sbjct: 582 --RLYGGMNYRRLGGGV 596
Score = 61.6 bits (148), Expect = 2e-09
Identities = 43/152 (28%), Positives = 75/152 (49%), Gaps = 8/152 (5%)
Query: 445 GGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFR 504
G +++ GG + + +DP T++W A M+ R + + D LY +GG+
Sbjct: 317 GEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHD-- 374
Query: 505 GTSDYDDVLSCEYYSPTLDQWTP-IAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 563
G+S + V E Y P +QW+ +A ++ VGVAV +Y VGG + + I
Sbjct: 375 GSSYLNSV---ERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQ--DGVSCLNI 429
Query: 564 VQKYDPEKDEWHKVFDLPESLGGIRACTLTVF 595
V++YDP++++W +V + G+ L F
Sbjct: 430 VERYDPKENKWTRVASMSTRRLGVAVAVLGGF 461
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 280 bits (715), Expect = 4e-75
Identities = 194/621 (31%), Positives = 294/621 (47%), Gaps = 70/621 (11%)
Query: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
H +L G+ LR EG LCDVTL +G E FP HR+++A +SDYF+A+F +E
Sbjct: 11 HGGALLTGYQALRAEGFLCDVTLET-EGSE-FPAHRSLLACSSDYFRALFKSHTQESRAR 68
Query: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
I LH + GL++++DFIYTA LSL+MD ++DTLEAAS+LQ+ L C +L ++
Sbjct: 69 VIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQLAP 128
Query: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGE----FLKLPFERLAFVLSSNSL 207
+NC +A + L I+ + LL+ G L+L L VL + +
Sbjct: 129 ENCCFAANVAARFGLAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVLGAPDV 188
Query: 208 KHCTELELFKAACRWLRLE--DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNT 265
E L A WLR E R+ + +L++ +RF L+ P D++ V + +
Sbjct: 189 ARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLV-PADVLRRVYSGSGLVLPAR 247
Query: 266 CVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVV------------ 313
L+++A NY P QP+MQ ++T+IRS T ++ +GG +++V+
Sbjct: 248 VKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQRAARG 307
Query: 314 --------SKELRMYDERAQE-----------------WRSLAPMDAPRYQHGIAVIGNF 348
+E + +E +E WRSL + P H + GNF
Sbjct: 308 QVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVCTAGNF 367
Query: 349 LYVVGGQSNYDTKGKTAVD-------TVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHL 401
L+V+GG+S + D V R+DPR++ W +V ++ E R F A+ L
Sbjct: 368 LFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERL 427
Query: 402 YAVGGRSAAGE-LATVECYNPRMNEWSYVAKMSEPHYGHAGTVYG-GLMYISGGIT---- 455
AVGG A GE LA+VE Y+ R + W+ + +GHAG V G++YISGG
Sbjct: 428 LAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGE 487
Query: 456 -HDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS 514
+ +L P+ W +KAPM T R G + V+ G F Y+
Sbjct: 488 GGASSLRDLYVLGPEEQVWSKKAPMGTAR-------FGHHMAVLRGAVFAFLGRYEPFSE 540
Query: 515 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI--VQKYDPEKD 572
E Y P DQWT + + + G+AV E ++GG W + V V YD + D
Sbjct: 541 IERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKWRDSRQVPTRNVVGYDLDLD 600
Query: 573 EWHKV-FDLPESLGGIRACTL 592
W + LP + G+R L
Sbjct: 601 RWEDIGCALPWAWSGLRCAVL 621
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 279 bits (714), Expect = 5e-75
Identities = 176/532 (33%), Positives = 276/532 (51%), Gaps = 17/532 (3%)
Query: 67 RAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTL 126
R +++S SDYF AMFT ++E IK+ GV L +I + YT +L L DN++ L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 127 EAASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLS 186
A LQ+ V++ C FL+ + NC+ + A+ ++ K +N+ +++F ++
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 187 TGEFLKLPFERLAFVLSSNSLKHCTELELFKAACRWLR--LEDPRMDYAAKLMKNIRFPL 244
EF+ LP +A +L+S+ + E + A W+R LE R D +KL+ IR PL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKD-LSKLLAYIRLPL 352
Query: 245 MTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTL 303
+ PQ L + V F R D C L++EA Y ++P +P++QS RT R + L +
Sbjct: 353 LAPQFLADMENNVLF-RDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAV 411
Query: 304 GGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK 363
GG+ + S + YD R W +A M+ R Q G+AV+ + LYVVGG+ G
Sbjct: 412 GGMDSTKGATS--IEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD-----GL 464
Query: 364 TAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRM 423
++TV ++P+ W + ++ R ++ L+G +YAVGG L TVE ++P+
Sbjct: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 524
Query: 424 NEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVR 483
+W++VA MS P V G +Y GG + + CFDP T+KW A M+ R
Sbjct: 525 RQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRR 584
Query: 484 GLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSC-EYYSPTLDQWTPIAAMLRGQSDVGVAV 542
G + T LY IGG+ ++ + C E Y P D WT +A+M + VGV +
Sbjct: 585 GGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCL 644
Query: 543 FENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTV 594
+K+Y VGGY + + + V+ YDP+ +EW +V P LG AC +TV
Sbjct: 645 LGDKLYAVGGY--DGQAYLNTVEAYDPQTNEWTQV--APLCLGRAGACVVTV 692
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 269 bits (688), Expect = 5e-72
Identities = 177/551 (32%), Positives = 277/551 (50%), Gaps = 16/551 (2%)
Query: 29 SNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQ 88
++ HS +LQG + LR LCD+ L GD H+ ++AS S YFKAMFTG + E+
Sbjct: 14 THLHSEQLLQGLNLLRQHHELCDIILRVGDVK--IHAHKVVLASVSPYFKAMFTGNLSEK 71
Query: 89 DLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 148
+ ++ +++ L+ I+++ YT + ++ D ++ L AA+ LQI VL C FL S
Sbjct: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131
Query: 149 VSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLK 208
+ NC+ + R A TY ++ +I +NF A+ T EF +L L ++S++ L
Sbjct: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191
Query: 209 HCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCV 267
TE +F A W++ + R Y A+L+ ++R PL++ + L + +R D TC
Sbjct: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
Query: 268 NLLLEASNYQMMPYMQPVMQSD-RTAIRSDSTHLVTLGGVLRQQLVVSKELRMYDERAQE 326
+LL EA Y MP + Q+ T R L +GG + MY +
Sbjct: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGG-KSGLFACLDSVEMYFPQNDS 310
Query: 327 WRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTA---VDTVFRFDPRYNKWMQVA 383
W LAP++ PRY+ GI V+ +YV+GG + G T ++V ++P N W +
Sbjct: 311 WIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370
Query: 384 SLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTV 443
+NE R+ + L G LYA+GG L +VE Y P++ +W VA M+ A V
Sbjct: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
Query: 444 YGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHF 503
G++Y GG N + +DP D W A M R + + ++V+GG++
Sbjct: 431 LDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN- 488
Query: 504 RGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEI 563
G S + S E Y P +QWT M ++ VG AV +N +YVVGG+S ++ +
Sbjct: 489 -GVS---HLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSS--YLNT 542
Query: 564 VQKYDPEKDEW 574
VQKYDP D W
Sbjct: 543 VQKYDPISDTW 553
Score = 110 bits (275), Expect = 4e-24
Identities = 58/193 (30%), Positives = 96/193 (49%), Gaps = 13/193 (6%)
Query: 300 LVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD 359
L LGG Q + S E Y + ++W+ +APM R AV+ +Y +GG
Sbjct: 388 LYALGGYDGQSYLQSVE--KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY---- 441
Query: 360 TKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECY 419
G +++V R+DP + W VAS+ +KR F + + G ++ VGG + L+++E Y
Sbjct: 442 --GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERY 499
Query: 420 NPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPM 479
+P N+W+ M EP G V +Y+ GG + ++ N + +DP +D W+ A M
Sbjct: 500 DPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM 559
Query: 480 TTVRGLHCMCTVG 492
++C C G
Sbjct: 560 -----IYCRCNFG 567
Score = 88.6 bits (218), Expect = 2e-17
Identities = 58/191 (30%), Positives = 89/191 (46%), Gaps = 17/191 (8%)
Query: 401 LYAVGGRSAAGE-LATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDT- 458
L AVGG+S L +VE Y P+ + W +A ++ P Y V +Y+ GGI +
Sbjct: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
Query: 459 -------FQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDD 511
+N + C++PDT+ W M R + + +LY +GG + G S
Sbjct: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGG--YDGQSYLQS 402
Query: 512 VLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEK 571
V E Y P + +W P+A M +S AV + IY +GGY + V++YDP K
Sbjct: 403 V---EKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYG---PAHMNSVERYDPSK 456
Query: 572 DEWHKVFDLPE 582
D W V + +
Sbjct: 457 DSWEMVASMAD 467
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/81 (38%), Positives = 43/81 (53%), Gaps = 5/81 (6%)
Query: 317 LRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRY 376
+ YD +W PM PR G AVI N+LYVVGG S G + ++TV ++DP
Sbjct: 496 IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHS-----GSSYLNTVQKYDPIS 550
Query: 377 NKWMQVASLNEKRTFFHLSAL 397
+ W+ A + R F L+AL
Sbjct: 551 DTWLDSAGMIYCRCNFGLTAL 571
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 268 bits (686), Expect = 8e-72
Identities = 173/569 (30%), Positives = 277/569 (48%), Gaps = 17/569 (2%)
Query: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
H+ L+ + E LCDV L+ G P HR ++++ SDYF AMFT + E
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLR--IPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
Query: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
+++ GV+ L ++ + YT L L D ++ L AA LQ+ V+D C FLI +
Sbjct: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
Query: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 211
NC+ + + E+ + + +++F ++ EFL LP ++ +L S+ +
Sbjct: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
Query: 212 ELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL 270
E +F A +W+ + R L+ IR PL+ PQ L+ ++T D C LL
Sbjct: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLL 400
Query: 271 LEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTLGGVLRQQLVVSKELRMYDERAQEWRS 329
+EA Y ++P + +MQS RT R + L +GG+ + + + YD R W
Sbjct: 401 MEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM--DAMKGTTTIEKYDLRTNSWLH 458
Query: 330 LAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKR 389
+ M+ R Q G+AVI N LYVVGG+ G ++TV F+P W + ++ R
Sbjct: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHR 513
Query: 390 TFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMY 449
++ L+G +YAVGG L TVE ++P +W+YVA MS P +Y
Sbjct: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
Query: 450 ISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDY 509
GG + + FDP T+KW APM+ RG + T LYV+GG+ ++
Sbjct: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
Query: 510 DDVLSC-EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYD 568
+ C E Y P D W+ +A + + V V +K+YVVGGY + + V+ YD
Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNTVESYD 691
Query: 569 PEKDEWHKVFDLPESLGGIRACTLTVFPP 597
+++EW + ++P ++G AC + V P
Sbjct: 692 AQRNEWKE--EVPVNIGRAGACVVVVKLP 718
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 267 bits (682), Expect = 2e-71
Identities = 178/552 (32%), Positives = 277/552 (50%), Gaps = 21/552 (3%)
Query: 41 DQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLMCIKLHGVNK 100
+++R +G LCDVTL GD F HR ++A++ YF AMFT M E I + G++
Sbjct: 29 EEIRRQGKLCDVTLKIGDHK--FSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDP 86
Query: 101 VGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSLDNCVEVGRI 160
L+ +I+F Y L+++ N+Q L ASFLQ+ + D C FL + NC+ V +
Sbjct: 87 SALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQF 146
Query: 161 ANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCTELELFKAAC 220
A T + N+FI ++F + + EFL LP E + ++S + L +E ++F+AA
Sbjct: 147 AETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAAL 206
Query: 221 RWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLLLEASNYQMM 279
W+R + + R Y +L+ NIR PL PQ L + VQ D +R + C +L+ EA +Y +M
Sbjct: 207 AWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLM 266
Query: 280 PYMQPVMQSDRTAIR--SDSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPR 337
P +P + + RT R + L+ G L + ++D A W PM R
Sbjct: 267 PERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTAR 326
Query: 338 YQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSAL 397
+ G+AV+ LY +GG YD G+ + TV ++P + W +V S+N KR+ L
Sbjct: 327 SRVGVAVVNGLLYAIGG---YD--GQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVL 381
Query: 398 KGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHD 457
G +Y GG L++VE Y+P ++W+ V MS TV+ G +Y+SGG HD
Sbjct: 382 DGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG--HD 439
Query: 458 TFQ--NELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSC 515
Q + + ++ T W A M R H ++G K++V GG G +
Sbjct: 440 GLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGF-----LSIA 494
Query: 516 EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWH 575
E YS DQW I M +S V + ++Y VGGY + + + V+ YDPE D W
Sbjct: 495 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGY--DGQSNLSSVEMYDPETDCWT 552
Query: 576 KVFDLPESLGGI 587
+ + GG+
Sbjct: 553 FMAPMACHEGGV 564
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 264 bits (674), Expect = 2e-70
Identities = 172/585 (29%), Positives = 289/585 (49%), Gaps = 27/585 (4%)
Query: 21 AGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAM 80
+ + F+ + H+ + + + LCDV L+ G+ P HR +++S SDYF AM
Sbjct: 183 SSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRK--IPAHRLVLSSVSDYFAAM 240
Query: 81 FTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDF 140
FT + E IK+ G++ L ++ F YT L L D +++ L AA LQ+ V++
Sbjct: 241 FTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEV 300
Query: 141 CKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAF 200
C FL+ + NC+ + A+ IE+ K +++ ++N ++ EFL LP E L
Sbjct: 301 CCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHK 360
Query: 201 VLSSNSLKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDF 259
+L+S+ + E +F A W++ + R + + L+ IR PL+ PQ L + ++
Sbjct: 361 LLASDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHAL 419
Query: 260 MRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTLGGVLRQQLVVSKELR 318
+ D C L+LEA Y ++P + +MQS RT R + L +GG+ + + +
Sbjct: 420 FKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATT--IE 477
Query: 319 MYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNK 378
YD R W M+ R Q G+AVI + L+V+GG+ G ++TV ++P+
Sbjct: 478 KYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRD-----GLKTLNTVECYNPKTKT 532
Query: 379 WMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYG 438
W + ++ R ++ L+G +YAVGG L TVE ++P+ +W++VA MS
Sbjct: 533 WTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARST 592
Query: 439 HAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVI 498
G +Y GG + + + +DP T+KW APM RG + T LY +
Sbjct: 593 VGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAV 652
Query: 499 GG------NHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGG 552
GG NH DY E Y P D WT +A + + VGV + +++Y VGG
Sbjct: 653 GGHDAPASNHCSRLLDY-----VERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG 707
Query: 553 YSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPP 597
Y + + + ++ YDP+ +EW ++ L ++G AC + + P
Sbjct: 708 Y--DGQTYLNTMESYDPQTNEWTQMASL--NIGRAGACVVVIKQP 748
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 261 bits (668), Expect = 1e-69
Identities = 167/546 (30%), Positives = 265/546 (48%), Gaps = 15/546 (2%)
Query: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
H+ L+ + E LCDV L+ G P HR ++++ SDYF AMFT + E
Sbjct: 164 HAEQTLRKMENYLKEKQLCDVLLIAGHLR--IPAHRLVLSAVSDYFAAMFTNDVLEAKQE 221
Query: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
+++ GV+ L ++ + YT L L D ++ L AA LQ+ V+D C FLI +
Sbjct: 222 EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHP 281
Query: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 211
NC+ + + E+ + + +++F ++ EFL LP ++ +L S+ +
Sbjct: 282 SNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPD 341
Query: 212 ELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL 270
E +F A +W+ + R L+ IR PL+ PQ L+ ++T D C LL
Sbjct: 342 EETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGDLECQKLL 400
Query: 271 LEASNYQMMPYMQPVMQSDRTAIRSDST-HLVTLGGVLRQQLVVSKELRMYDERAQEWRS 329
+EA Y ++P + +MQS RT R + L +GG+ + + + YD R W
Sbjct: 401 MEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGM--DAMKGTTTIEKYDLRTNSWLH 458
Query: 330 LAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKR 389
+ M+ R Q G+AVI N LYVVGG+ G ++TV F+P W + ++ R
Sbjct: 459 IGTMNGRRLQFGVAVIDNKLYVVGGRD-----GLKTLNTVECFNPVGKIWTVMPPMSTHR 513
Query: 390 TFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMY 449
++ L+G +YAVGG L TVE ++P +W+YVA MS P +Y
Sbjct: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
Query: 450 ISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDY 509
GG + + FDP T+KW APM+ RG + T LYV+GG+ ++
Sbjct: 574 AIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHC 633
Query: 510 DDVLSC-EYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYD 568
+ C E Y P D W+ +A + + V V +K+YVVGGY + + V+ YD
Sbjct: 634 SRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGY--DGHTYLNTVESYD 691
Query: 569 PEKDEW 574
+++EW
Sbjct: 692 AQRNEW 697
Score = 87.8 bits (216), Expect = 3e-17
Identities = 57/197 (28%), Positives = 91/197 (46%), Gaps = 7/197 (3%)
Query: 399 GHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDT 458
G LYAVGG A T+E Y+ R N W ++ M+ V +Y+ GG
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLK 488
Query: 459 FQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYY 518
N + CF+P W PM+T R + T+ +Y +GG+ G S + V E +
Sbjct: 489 TLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHD--GWSYLNTV---ERW 543
Query: 519 SPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVF 578
P QW +A+M +S VGV NK+Y +GG ++ ++ ++ +DP ++W
Sbjct: 544 DPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS--CLKSMEYFDPHTNKWSLCA 601
Query: 579 DLPESLGGIRACTLTVF 595
+ + GG+ T F
Sbjct: 602 PMSKRRGGVGVATYNGF 618
Score = 85.9 bits (211), Expect = 1e-16
Identities = 47/162 (29%), Positives = 77/162 (47%), Gaps = 11/162 (6%)
Query: 320 YDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 379
+D ++W +A M PR G+ + N LY +GG+ G + + ++ FDP NKW
Sbjct: 543 WDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRD-----GSSCLKSMEYFDPHTNKW 597
Query: 380 MQVASLNEKRTFFHLSALKGHLYAVGGRSAAGE------LATVECYNPRMNEWSYVAKMS 433
A ++++R ++ G LY VGG A VE Y+P+ + WS VA +S
Sbjct: 598 SLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLS 657
Query: 434 EPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQ 475
P A G +Y+ GG T+ N + +D ++W +
Sbjct: 658 VPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 260 bits (664), Expect = 3e-69
Identities = 166/553 (30%), Positives = 287/553 (51%), Gaps = 30/553 (5%)
Query: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
H + ++LR + LLCDVT+V D + HR ++A+ S YF AMFTG M E
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDME--ISAHRVVLAACSPYFHAMFTGEMSESRAK 99
Query: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
+++ V+ L+ +ID++YTA++ + +N+Q L AA LQ+ V C FL S +
Sbjct: 100 RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 159
Query: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 211
NC+ + A+ + ++ N + ++F ++ + EFL L E++ ++SS+ L +
Sbjct: 160 VNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISS 219
Query: 212 ELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL 270
E ++F+A W+ + D R ++ A+LM+++R PL+ + L+ V+ ++ + C + L
Sbjct: 220 EEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYL 279
Query: 271 LEASNYQMMPYMQPV-MQSDRTAIRSDST---HLVTLGGVLRQQLVVSKELRMYDERAQE 326
+EA Y ++P Q + M+S RT +R+ +V +GG Q + + YD + +
Sbjct: 280 IEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVECYDFKEER 336
Query: 327 WRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLN 386
W +A + + R + G+ + ++ VGG G V TV +DP ++W VA++
Sbjct: 337 WHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQWTSVANMR 391
Query: 387 EKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGG 446
++R+ + L G LYAVGG + L++VE YN + NEW +VA M+ V GG
Sbjct: 392 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 451
Query: 447 LMYISGGITHDTFQ--NELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFR 504
L+Y GG + Q + + C++ T++W A M+T R + + + LY +GG
Sbjct: 452 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG---- 507
Query: 505 GTSDYDDVL---SCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 561
+D L S E Y PT + W +A M + + GV +YVVGG + C +
Sbjct: 508 ----HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL 561
Query: 562 EIVQKYDPEKDEW 574
V+ Y+P D+W
Sbjct: 562 ASVEYYNPTTDKW 574
Score = 76.3 bits (186), Expect = 8e-14
Identities = 54/187 (28%), Positives = 83/187 (44%), Gaps = 7/187 (3%)
Query: 401 LYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVY-GGLMYISGGITHDTF 459
L V G A + +VECY+ + W VA++ AG VY GL++ GG
Sbjct: 312 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC-RAGMVYMAGLVFAVGGFNGSLR 370
Query: 460 QNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYS 519
+ +DP D+W A M R + LY +GG F G++ V E Y+
Sbjct: 371 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG--FDGSTGLSSV---EAYN 425
Query: 520 PTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFD 579
++W +A M +S VGV V +Y VGGY +R + V+ Y+ +EW + +
Sbjct: 426 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 485
Query: 580 LPESLGG 586
+ G
Sbjct: 486 MSTRRSG 492
Score = 76.3 bits (186), Expect = 8e-14
Identities = 43/122 (35%), Positives = 59/122 (48%), Gaps = 5/122 (4%)
Query: 320 YDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 379
Y+ EW +A M R G+ V+ N LY VGG G +V +DP N W
Sbjct: 473 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-----GPLVRKSVEVYDPTTNAW 527
Query: 380 MQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGH 439
QVA +N R + A+ G LY VGG + LA+VE YNP ++W+ V+ +
Sbjct: 528 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSY 587
Query: 440 AG 441
AG
Sbjct: 588 AG 589
Score = 39.3 bits (90), Expect = 0.011
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 512 VLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEK 571
+ S E Y ++W +A + + G+ ++ VGG+ N V V YDP K
Sbjct: 324 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 381
Query: 572 DEWHKVFDLPESLGGIRACTL 592
D+W V ++ + + A L
Sbjct: 382 DQWTSVANMRDRRSTLGAAVL 402
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 260 bits (664), Expect = 3e-69
Identities = 166/553 (30%), Positives = 287/553 (51%), Gaps = 30/553 (5%)
Query: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
H + ++LR + LLCDVT+V D + HR ++A+ S YF AMFTG M E
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDME--ISAHRVVLAACSPYFHAMFTGEMSESRAK 95
Query: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
+++ V+ L+ +ID++YTA++ + +N+Q L AA LQ+ V C FL S +
Sbjct: 96 RVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 155
Query: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 211
NC+ + A+ + ++ N + ++F ++ + EFL L E++ ++SS+ L +
Sbjct: 156 VNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISS 215
Query: 212 ELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL 270
E ++F+A W+ + D R ++ A+LM+++R PL+ + L+ V+ ++ + C + L
Sbjct: 216 EEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYL 275
Query: 271 LEASNYQMMPYMQPV-MQSDRTAIRSDST---HLVTLGGVLRQQLVVSKELRMYDERAQE 326
+EA Y ++P Q + M+S RT +R+ +V +GG Q + + YD + +
Sbjct: 276 IEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVECYDFKEER 332
Query: 327 WRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLN 386
W +A + + R + G+ + ++ VGG G V TV +DP ++W VA++
Sbjct: 333 WHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQWTSVANMR 387
Query: 387 EKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGG 446
++R+ + L G LYAVGG + L++VE YN + NEW +VA M+ V GG
Sbjct: 388 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 447
Query: 447 LMYISGGITHDTFQ--NELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFR 504
L+Y GG + Q + + C++ T++W A M+T R + + + LY +GG
Sbjct: 448 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG---- 503
Query: 505 GTSDYDDVL---SCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMV 561
+D L S E Y PT + W +A M + + GV +YVVGG + C +
Sbjct: 504 ----HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD--DGSCNL 557
Query: 562 EIVQKYDPEKDEW 574
V+ Y+P D+W
Sbjct: 558 ASVEYYNPTTDKW 570
Score = 76.3 bits (186), Expect = 8e-14
Identities = 54/187 (28%), Positives = 83/187 (44%), Gaps = 7/187 (3%)
Query: 401 LYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVY-GGLMYISGGITHDTF 459
L V G A + +VECY+ + W VA++ AG VY GL++ GG
Sbjct: 308 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC-RAGMVYMAGLVFAVGGFNGSLR 366
Query: 460 QNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYS 519
+ +DP D+W A M R + LY +GG F G++ V E Y+
Sbjct: 367 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG--FDGSTGLSSV---EAYN 421
Query: 520 PTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFD 579
++W +A M +S VGV V +Y VGGY +R + V+ Y+ +EW + +
Sbjct: 422 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 481
Query: 580 LPESLGG 586
+ G
Sbjct: 482 MSTRRSG 488
Score = 76.3 bits (186), Expect = 8e-14
Identities = 43/122 (35%), Positives = 59/122 (48%), Gaps = 5/122 (4%)
Query: 320 YDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 379
Y+ EW +A M R G+ V+ N LY VGG G +V +DP N W
Sbjct: 469 YNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-----GPLVRKSVEVYDPTTNAW 523
Query: 380 MQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGH 439
QVA +N R + A+ G LY VGG + LA+VE YNP ++W+ V+ +
Sbjct: 524 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSY 583
Query: 440 AG 441
AG
Sbjct: 584 AG 585
Score = 39.3 bits (90), Expect = 0.011
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 512 VLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEK 571
+ S E Y ++W +A + + G+ ++ VGG+ N V V YDP K
Sbjct: 320 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 377
Query: 572 DEWHKVFDLPESLGGIRACTL 592
D+W V ++ + + A L
Sbjct: 378 DQWTSVANMRDRRSTLGAAVL 398
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 259 bits (661), Expect = 7e-69
Identities = 177/570 (31%), Positives = 282/570 (49%), Gaps = 68/570 (11%)
Query: 32 HSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQDLM 91
H + ++LR + LLCDV +V D + HR ++A+ S YF AMFTG M E
Sbjct: 32 HMGKAFKVMNELRSKQLLCDVMIVAEDVE--IEAHRVVLAACSPYFCAMFTGDMSESKAK 89
Query: 92 CIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISGVSL 151
I++ V+ L K+ID+IYTA++ + +N+Q L AAS LQ++ V C FL S +
Sbjct: 90 KIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 149
Query: 152 DNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLKHCT 211
NC+ + A+ + ++ + N + ++FP ++ EFL L +++ ++SS+ L +
Sbjct: 150 TNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSS 209
Query: 212 ELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCVNLL 270
E ++F+A W+ E + R+++ AKLM+++R PL+ L+ V+ ++ +NTC + L
Sbjct: 210 EEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFL 269
Query: 271 LEASNYQMMPYMQPVM-QSDRT---------------------AIRS------------- 295
+EA Y ++P Q ++ ++ RT AIRS
Sbjct: 270 IEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQ 329
Query: 296 ---------------DSTHLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQH 340
+ H+ +GG V + + +YD +W S+A M R
Sbjct: 330 IAELPSRRCRAGVVFMAGHVYAVGGFNGSLRV--RTVDVYDGVKDQWTSIASMQERRSTL 387
Query: 341 GIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGH 400
G AV+ + LY VGG +D G T + +V + + N+W VA +N +R+ + ++G
Sbjct: 388 GAAVLNDLLYAVGG---FD--GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGK 442
Query: 401 LYAVGGRSAAGE--LATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDT 458
LYAVGG A L+TVE YNP NEW YVA MS G V G +Y +GG
Sbjct: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502
Query: 459 FQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYY 518
+ + +DP T+ W Q A M R +C V LYV+GG+ ++ S EYY
Sbjct: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGD-----DGSCNLASVEYY 557
Query: 519 SPTLDQWTPIAA-MLRGQSDVGVAVFENKI 547
+P D+WT + M G+S GVAV +
Sbjct: 558 NPVTDKWTLLPTNMSTGRSYAGVAVIHKSL 587
Score = 84.3 bits (207), Expect = 3e-16
Identities = 58/187 (31%), Positives = 89/187 (47%), Gaps = 8/187 (4%)
Query: 401 LYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVY-GGLMYISGGITHDTF 459
+ VGG+ A + +VECY+ + W +A++ AG V+ G +Y GG
Sbjct: 303 MIVVGGQ-APKAIRSVECYDFEEDRWDQIAELPSRRC-RAGVVFMAGHVYAVGGFNGSLR 360
Query: 460 QNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYS 519
+ +D D+W A M R + D LY +GG F G++ + S E YS
Sbjct: 361 VRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGG--FDGSTG---LASVEAYS 415
Query: 520 PTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFD 579
++W +A M +S VGV V E K+Y VGGY +R + V++Y+P +EW V D
Sbjct: 416 YKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVAD 475
Query: 580 LPESLGG 586
+ G
Sbjct: 476 MSTRRSG 482
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/81 (29%), Positives = 34/81 (41%), Gaps = 2/81 (2%)
Query: 512 VLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEK 571
+ S E Y D+W IA + + GV +Y VGG+ N V V YD K
Sbjct: 314 IRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF--NGSLRVRTVDVYDGVK 371
Query: 572 DEWHKVFDLPESLGGIRACTL 592
D+W + + E + A L
Sbjct: 372 DQWTSIASMQERRSTLGAAVL 392
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 258 bits (659), Expect = 1e-68
Identities = 165/562 (29%), Positives = 269/562 (47%), Gaps = 55/562 (9%)
Query: 29 SNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQ 88
S H ++R GLLCD+ L + H+ ++AS S YF AMFT M E
Sbjct: 71 SKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKE--IRAHKVVLASCSPYFHAMFTNEMSES 128
Query: 89 DLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 148
+ LH ++ L +++ F YTA++ + N+Q L AAS LQ+ V D C FL+S
Sbjct: 129 RQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188
Query: 149 VSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLK 208
+ NC+ + A+ ++ ++ K + ++L++F + T EF+ LP +++ ++SS+SL
Sbjct: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248
Query: 209 HCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCV 267
+E E+++A W++ + D R + +LMK +R PL++ L+ +V +R C
Sbjct: 249 VPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCK 308
Query: 268 NLLLEASNYQMMPYMQPVMQSDRTAIR---SDSTHLVTLGGVLRQQLVVSKELRMYDERA 324
+LL+EA + ++P + V+ + RT R L +GG + + YD R
Sbjct: 309 DLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGG--GSLFAIHGDCEAYDTRT 366
Query: 325 QEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQ---------SNYDT--------------- 360
W +A M R + G+A +GN LY VGG +YD
Sbjct: 367 DRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRR 426
Query: 361 ------------------KGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLY 402
G + +++ R+DP W VA+++ +R + ++ L G+LY
Sbjct: 427 SCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLY 486
Query: 403 AVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNE 462
AVGG ++ LATVE Y P++N WS VA M V G +Y++GG + N
Sbjct: 487 AVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNS 546
Query: 463 LMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTL 522
+ + P W APM R H + + LY +GGN G+S + S E Y+P
Sbjct: 547 VERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGND--GSSSLN---SIEKYNPRT 601
Query: 523 DQWTPIAAMLRGQSDVGVAVFE 544
++W + M +S VGVAV E
Sbjct: 602 NKWVAASCMFTRRSSVGVAVLE 623
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 250 bits (638), Expect = 3e-66
Identities = 158/567 (27%), Positives = 273/567 (48%), Gaps = 16/567 (2%)
Query: 29 SNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGMKEQ 88
+NTH+ +L + LR LCDVTL D FP HR ++A+ SDYF AMFT + E+
Sbjct: 12 TNTHAKSILNSMNSLRKSNTLCDVTLRVEQKD--FPAHRIVLAACSDYFCAMFTSELSEK 69
Query: 89 DLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLISG 148
+ + G+ ++ ++DF+YT + + ++N+Q+ L AA LQ+ V C FL S
Sbjct: 70 GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
Query: 149 VSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSNSLK 208
+ NC+ + A T+N +++ + F K+FP ++ EF+ L + ++ + ++
Sbjct: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
Query: 209 HCTELELFKAACRWLR-LEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDNTCV 267
+E +F+A W++ + R + L++ +R PL+TP+ + + + F+R C
Sbjct: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
Query: 268 NLLLEASNYQMMPYMQPVMQSDRTAIRSDSTH-LVTLGGVLRQQLVVSKELRMYDERAQE 326
+L+ EA + + P ++ MQ RT R + L+ +GG QQ + + YD + QE
Sbjct: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPID-VVEKYDPKTQE 308
Query: 327 WRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGK-TAVDTVFRFDPRYNKWMQVASL 385
W L + R + + +YV+GG YD + + ++V+ + W VA +
Sbjct: 309 WSFLPSITRKRRYVASVSLHDRIYVIGG---YDGRSRLSSVECLDYTADEDGVWYSVAPM 365
Query: 386 NEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYG 445
N +R + L +Y GG + ++E Y+P +++WS + M G V
Sbjct: 366 NVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
Query: 446 GLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRG 505
G++Y GG N + +DP T W PM T R + + D +YV+GG F G
Sbjct: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGG--FDG 483
Query: 506 TSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQ 565
T+ V E Y+ D WT + +M + VG V ++Y + GY N+ ++ ++
Sbjct: 484 TAHLSSV---EAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNS--LLSSIE 538
Query: 566 KYDPEKDEWHKVFDLPESLGGIRACTL 592
YDP D W V + C L
Sbjct: 539 CYDPIIDSWEVVTSMGTQRCDAGVCVL 565
Score = 93.6 bits (231), Expect = 5e-19
Identities = 52/178 (29%), Positives = 81/178 (45%), Gaps = 5/178 (2%)
Query: 317 LRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRY 376
+ YD +W L M R G+ V +Y +GG YD G +++V ++DP
Sbjct: 396 MERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG---YD--GLNILNSVEKYDPHT 450
Query: 377 NKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPH 436
W V + KR+ ++ L H+Y VGG L++VE YN R + W+ V M+ P
Sbjct: 451 GHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPR 510
Query: 437 YGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDK 494
TV G +Y G ++ + + C+DP D W M T R +C + +K
Sbjct: 511 CYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK 568
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 241 bits (616), Expect = 1e-63
Identities = 158/579 (27%), Positives = 264/579 (45%), Gaps = 19/579 (3%)
Query: 14 AHLQPCKAGTTRF-FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEI---FPVHRAM 69
A + P + G F +T H+ ++LR+ LCDVTL D F H+ +
Sbjct: 40 AEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVV 99
Query: 70 MASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAA 129
+AS+S FKAMFT G++EQ + + + G++ ++++I+F YTA +S+ + + A
Sbjct: 100 LASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGA 159
Query: 130 SFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGE 189
QI V+ C FL+ + N + + A +E+ + +I +F + E
Sbjct: 160 VMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEE 219
Query: 190 FLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQ 248
F L +L ++S + L E E+F A W++ + + R Y L++ +R +TP
Sbjct: 220 FFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPN 279
Query: 249 DLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLR 308
L +Q + +++D+ C + L++ + VM + + T GG R
Sbjct: 280 FLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKV---GRLIYTAGGYFR 336
Query: 309 QQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDT 368
Q L L Y+ W LA + PR V+G LY VGG++N G T
Sbjct: 337 QSL---SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN-SPDGNTDSSA 392
Query: 369 VFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSY 428
+ ++P N+W A ++ R + + GH+YAVGG +VE Y P +EW
Sbjct: 393 LDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHL 452
Query: 429 VAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCM 488
VA M G V L+Y GG N C+ P+ ++W M T+R +
Sbjct: 453 VAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGV 512
Query: 489 CTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIY 548
C + + +Y G G D + S E Y + WT +A M +S +G+ V + +IY
Sbjct: 513 CVLHNCIYAAG-----GYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIY 567
Query: 549 VVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGI 587
V+GGY + ++ V+ YDP+ D W +V + G+
Sbjct: 568 VLGGY--DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGV 604
Score = 104 bits (259), Expect = 3e-22
Identities = 64/198 (32%), Positives = 95/198 (47%), Gaps = 11/198 (5%)
Query: 399 GHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITH-- 456
G L G L+ +E YNP W +A + P G AG V GGL+Y GG +
Sbjct: 325 GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSP 384
Query: 457 --DTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS 514
+T + L C++P T++W APM+ R + + +Y +GG+H G ++ V
Sbjct: 385 DGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSV-- 440
Query: 515 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW 574
E Y P D+W +A ML + VGVAV +Y VGG+ NR + + Y PE++EW
Sbjct: 441 -ERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEW 497
Query: 575 HKVFDLPESLGGIRACTL 592
+ + G C L
Sbjct: 498 RMITAMNTIRSGAGVCVL 515
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 241 bits (616), Expect = 1e-63
Identities = 158/579 (27%), Positives = 264/579 (45%), Gaps = 19/579 (3%)
Query: 14 AHLQPCKAGTTRF-FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEI---FPVHRAM 69
A + P + G F +T H+ ++LR+ LCDVTL D F H+ +
Sbjct: 40 AEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVV 99
Query: 70 MASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAA 129
+AS+S FKAMFT G++EQ + + + G++ ++++I+F YTA +S+ + + A
Sbjct: 100 LASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGA 159
Query: 130 SFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGE 189
QI V+ C FL+ + N + + A +E+ + +I +F + E
Sbjct: 160 VMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEE 219
Query: 190 FLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQ 248
F L +L ++S + L E E+F A W++ + + R Y L++ +R +TP
Sbjct: 220 FFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPN 279
Query: 249 DLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLR 308
L +Q + +++D+ C + L++ + VM + + T GG R
Sbjct: 280 FLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKV---GRLIYTAGGYFR 336
Query: 309 QQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDT 368
Q L L Y+ W LA + PR V+G LY VGG++N G T
Sbjct: 337 QSL---SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN-SPDGNTDSSA 392
Query: 369 VFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSY 428
+ ++P N+W A ++ R + + GH+YAVGG +VE Y P +EW
Sbjct: 393 LDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHL 452
Query: 429 VAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCM 488
VA M G V L+Y GG N C+ P+ ++W M T+R +
Sbjct: 453 VAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGV 512
Query: 489 CTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIY 548
C + + +Y G G D + S E Y + WT +A M +S +G+ V + +IY
Sbjct: 513 CVLHNCIYAAG-----GYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIY 567
Query: 549 VVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGI 587
V+GGY + ++ V+ YDP+ D W +V + G+
Sbjct: 568 VLGGY--DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGV 604
Score = 104 bits (259), Expect = 3e-22
Identities = 64/198 (32%), Positives = 95/198 (47%), Gaps = 11/198 (5%)
Query: 399 GHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITH-- 456
G L G L+ +E YNP W +A + P G AG V GGL+Y GG +
Sbjct: 325 GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSP 384
Query: 457 --DTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS 514
+T + L C++P T++W APM+ R + + +Y +GG+H G ++ V
Sbjct: 385 DGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSV-- 440
Query: 515 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW 574
E Y P D+W +A ML + VGVAV +Y VGG+ NR + + Y PE++EW
Sbjct: 441 -ERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEW 497
Query: 575 HKVFDLPESLGGIRACTL 592
+ + G C L
Sbjct: 498 RMITAMNTIRSGAGVCVL 515
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 237 bits (604), Expect = 3e-62
Identities = 163/583 (27%), Positives = 281/583 (48%), Gaps = 28/583 (4%)
Query: 21 AGTTRFFTSNTH---SSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYF 77
A +TRF + S++ + F++LR+EG LCDV ++ +G E F H+ ++ S S YF
Sbjct: 7 AASTRFHQPHMERKMSAMACEIFNELRLEGKLCDV-VIKVNGFE-FSAHKNILCSCSSYF 64
Query: 78 KAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPV 137
+A+FT G + + G++ +K II++ YT + + DN++ L AA I+ +
Sbjct: 65 RALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGI 124
Query: 138 LDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLS-TGEFLKLPFE 196
+ C FL S + LDNC+ + + + Y E+ + FIL NF ++ + EFL+L
Sbjct: 125 VRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVT 184
Query: 197 RLAFVLSSNSLKHCTELELFKAACRWLRLEDP--RMDYAAKLMKNIRFPLMTPQDLINYV 254
L ++ + L E +F+A +W+ DP R + + L+ +R LM + +N V
Sbjct: 185 ELKDIIEKDELNVKQEDAVFEAILKWIS-HDPQNRKQHISILLPKVRLALMHAEYFMNNV 243
Query: 255 QTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSD----RTAIRSDSTHLVTLGGVLRQQ 310
+ D+++ C +++ A M SD T R L +GG
Sbjct: 244 KMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGS 303
Query: 311 LVVSKELRMYDERAQEWRSLA-PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTV 369
+ + YD RA W ++ ++PR HG A + ++Y++GG + D ++V
Sbjct: 304 --PTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDY-----FNSV 356
Query: 370 FRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYV 429
RFDP W QVA ++ +R + ++ L +YA+GG L T E Y P N+W+ +
Sbjct: 357 KRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLI 416
Query: 430 AKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMC 489
A M E + T G +YI GG + ++ ++++W APM + R +
Sbjct: 417 APMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVI 476
Query: 490 TVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYV 549
G+ +Y +GG F G + + S E YSP + W I M +S+ G+ V ++ ++V
Sbjct: 477 AYGEHVYAVGG--FDGA---NRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFV 531
Query: 550 VGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTL 592
VGG+ N V+ YD + DEW+ D+ + C +
Sbjct: 532 VGGF--NGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVV 572
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 224 bits (572), Expect = 1e-58
Identities = 155/550 (28%), Positives = 267/550 (48%), Gaps = 30/550 (5%)
Query: 26 FFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAMFTGGM 85
F + ++H+ +LQ F++ R L DV ++ +G E FP HRA++++ S YF+AMF
Sbjct: 42 FSSGSSHAENILQIFNEFRDSRLFTDV-IICVEGKE-FPCHRAVLSACSSYFRAMFCNDH 99
Query: 86 KEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFL 145
+E M ++++G+ ++ + ++YT K+ + +N+Q E +S QI + D C FL
Sbjct: 100 RESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFL 159
Query: 146 ISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSSN 205
+ NC+ + R A+T++L + NF L+ F + EFL+L + L + S+
Sbjct: 160 EEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSD 219
Query: 206 SLKHCTELELFKAACRWL-RLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTDN 264
L E +F+A RW+ R D R +L+ ++R PL+ P + V+ ++
Sbjct: 220 ELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSP 279
Query: 265 TCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTH---LVTLGGVLRQQLVVSKELRMYD 321
C LL EA Y + + M S RT R + + +V +GG R YD
Sbjct: 280 ECYQLLHEARRYHI---LGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYD 336
Query: 322 ERAQEWRSLAPM-DAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWM 380
EW+SLA + + + ++ + + N + V GG+ N V+ ++ + N W+
Sbjct: 337 PVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRIN--------SRDVWIYNSQLNIWI 388
Query: 381 QVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHA 440
+VASLN+ R ++ L G +Y VGG L++VECY+ N W+ VA + E A
Sbjct: 389 RVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPA 448
Query: 441 GT-VYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIG 499
T G L I GG +T +++ +DP+T+ W+ +A + + ++ + +YV G
Sbjct: 449 VTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAG 508
Query: 500 GNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRC 559
G + C Y P D W + Q + G++V KIY++GG N
Sbjct: 509 G--------LTKAIYC--YDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEA 558
Query: 560 MVEIVQKYDP 569
+ + YDP
Sbjct: 559 -TDTILCYDP 567
Score = 68.9 bits (167), Expect = 1e-11
Identities = 49/177 (27%), Positives = 80/177 (45%), Gaps = 12/177 (6%)
Query: 401 LYAVGGRSAAG--ELATVECYNPRMNEWSYVAKMSE-PHYGHAGTVYGGLMYISGGITHD 457
+ VGG G L ECY+P EW +AK+ E +A + +SGG +
Sbjct: 315 IVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS 374
Query: 458 TFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEY 517
++ ++ + W++ A + R H M + K+YV+GG + + S E
Sbjct: 375 ---RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGY-----DGQNRLSSVEC 426
Query: 518 YSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW 574
Y ++WT +A + S V K++V+GG +N C + VQ YDPE + W
Sbjct: 427 YDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCS-DKVQSYDPETNSW 482
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 221 bits (563), Expect = 2e-57
Identities = 143/500 (28%), Positives = 258/500 (51%), Gaps = 28/500 (5%)
Query: 85 MKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 144
M E +++ V+ L+ +ID++YTA++ + +N+Q L AA LQ+ V C F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 145 LISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSS 204
L S + NC+ + A+ + ++ N + ++F ++ + EFL L E++ ++SS
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 205 NSLKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTD 263
+ L +E ++F+A W+ + D R ++ A+LM+++R PL+ + L+ V+ ++
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 264 NTCVNLLLEASNYQMMPYMQPV-MQSDRTAIRSDSTH---LVTLGGVLRQQLVVSKELRM 319
+ C + L+EA Y ++P Q + M+S RT +R+ +V +GG + + + +
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAI---RSVEC 237
Query: 320 YDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 379
YD + + W +A + + R + G+ + ++ VGG + G V TV +DP ++W
Sbjct: 238 YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN-----GSLRVRTVDSYDPVKDQW 292
Query: 380 MQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGH 439
VA++ ++R+ + L G LYAVGG + L++VE YN + NEW +VA M+
Sbjct: 293 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 352
Query: 440 AGTVYGGLMYISGGITHDTFQ--NELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYV 497
V GGL+Y GG + Q + + C++ T++W A M+T R + + + LY
Sbjct: 353 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYA 412
Query: 498 IGGNHFRGTSDYDDVL---SCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYS 554
+GG +D L S E Y PT + W +A M + + GV +YVVGG
Sbjct: 413 VGG--------HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD- 463
Query: 555 WNNRCMVEIVQKYDPEKDEW 574
+ C + V+ Y+P D+W
Sbjct: 464 -DGSCNLASVEYYNPTTDKW 482
Score = 76.3 bits (186), Expect = 8e-14
Identities = 54/187 (28%), Positives = 83/187 (44%), Gaps = 7/187 (3%)
Query: 401 LYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVY-GGLMYISGGITHDTF 459
L V G A + +VECY+ + W VA++ AG VY GL++ GG
Sbjct: 220 LMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC-RAGMVYMAGLVFAVGGFNGSLR 278
Query: 460 QNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYS 519
+ +DP D+W A M R + LY +GG F G++ V E Y+
Sbjct: 279 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGG--FDGSTGLSSV---EAYN 333
Query: 520 PTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFD 579
++W +A M +S VGV V +Y VGGY +R + V+ Y+ +EW + +
Sbjct: 334 IKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAE 393
Query: 580 LPESLGG 586
+ G
Sbjct: 394 MSTRRSG 400
Score = 44.7 bits (104), Expect = 3e-04
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 5/73 (6%)
Query: 312 VVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFR 371
+V K + +YD WR +A M+ R G+ + LYVVGG G + +V
Sbjct: 420 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDD-----GSCNLASVEY 474
Query: 372 FDPRYNKWMQVAS 384
++P +KW V+S
Sbjct: 475 YNPTTDKWTVVSS 487
Score = 39.3 bits (90), Expect = 0.011
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 512 VLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEK 571
+ S E Y ++W +A + + G+ ++ VGG+ N V V YDP K
Sbjct: 232 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 289
Query: 572 DEWHKVFDLPESLGGIRACTL 592
D+W V ++ + + A L
Sbjct: 290 DQWTSVANMRDRRSTLGAAVL 310
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 219 bits (559), Expect = 4e-57
Identities = 156/578 (26%), Positives = 275/578 (47%), Gaps = 29/578 (5%)
Query: 17 QPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDY 76
+ C F+S+ H+ ++L +++R CDV L G E F HR ++A++S Y
Sbjct: 4 EDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQ--ESFKAHRLVLAASSPY 61
Query: 77 FKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILP 136
F A+FTGGMKE + + G+ + ++DFIYT +++ ++N+Q+ + AA LQ+
Sbjct: 62 FAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTE 121
Query: 137 VLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFE 196
V+ C FL + NC+ + + + ++ ++ N+I +F + S EFL L +
Sbjct: 122 VVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKD 181
Query: 197 RLAFVLSSNSLKHCTELELFKAACRWLRLED--PRMDYAAKLMKNIRFPLMTPQDLINYV 254
+L +L S L E ++F AA +W+ L+D R + +++ IRFPL+ PQ L+ Y+
Sbjct: 182 QLIKILRSEELSIEDEYQVFLAAMQWI-LKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
Query: 255 QTVDFMRTDNTCVNLLLEASNYQMMPYMQ---PVMQSDRTAIRSDS-THLVTLGGVLRQQ 310
+ V LL E P +Q+ + R + +L +GG R Q
Sbjct: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
Query: 311 LVVSKELR------MYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKT 364
+ R +D +Q W +++ + R G+ V+G +Y +GG+ K
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-----KDSM 355
Query: 365 AVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMN 424
D +DP +W VAS+N R + G +YA+GG A T+E ++P N
Sbjct: 356 IFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDEN 415
Query: 425 EWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQ-NELMCFDPDTDKWMQKAPMTTVR 483
+W V M+ Y GL+Y+ GGI+++ + +DP + +W PM T R
Sbjct: 416 KWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRR 475
Query: 484 GLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVF 543
+ + D +Y +GG D + + E YS ++W +A+M ++ + V
Sbjct: 476 AYLGVAALNDCIYSVGG----WNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAV 531
Query: 544 ENKIYVVGGYSWNNRCM----VEIVQKYDPEKDEWHKV 577
+YV GG S ++ + ++ V+ Y+P D W ++
Sbjct: 532 NGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEI 569
Score = 54.7 bits (130), Expect = 2e-07
Identities = 44/173 (25%), Positives = 74/173 (42%), Gaps = 16/173 (9%)
Query: 418 CYNPRMNEWSYVAKMSEPHYGHAGTVY----GGLMYISGGITHDTFQNELMC---FDPDT 470
C +P+ N++ + S+ Y GG + GG D+ L C FD +
Sbjct: 263 CKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDS--RALSCVERFDTFS 320
Query: 471 DKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAA 530
W + + R + +G +Y IGG S D C Y P QWT +A+
Sbjct: 321 QYWTTVSSLHQARSGLGVTVLGGMVYAIGGEK---DSMIFDCTEC--YDPVTKQWTTVAS 375
Query: 531 MLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPES 583
M + +GV V IY +GG W + ++++DP++++W V ++ S
Sbjct: 376 MNHPRCGLGVCVCYGAIYALGG--WVGAEIGNTIERFDPDENKWEVVGNMAVS 426
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,544,704
Number of Sequences: 37866
Number of extensions: 1028890
Number of successful extensions: 3798
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 140
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 2198
Number of HSP's gapped (non-prelim): 408
length of query: 617
length of database: 18,247,518
effective HSP length: 108
effective length of query: 509
effective length of database: 14,157,990
effective search space: 7206416910
effective search space used: 7206416910
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.