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Search of human proteins with 239835724
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
(505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 1016 0.0
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 1016 0.0
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 1016 0.0
gi|166235129 kelch-like 3 [Homo sapiens] 835 0.0
gi|38194229 kelch-like 17 [Homo sapiens] 467 e-131
gi|40807500 kelch-like 20 [Homo sapiens] 412 e-115
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 393 e-109
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 393 e-109
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 393 e-109
gi|11056006 kelch-like 12 [Homo sapiens] 380 e-105
gi|14780904 kelch-like 1 protein [Homo sapiens] 369 e-102
gi|55925604 kelch-like 18 [Homo sapiens] 368 e-102
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 359 3e-99
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 357 1e-98
gi|34101268 kelch-like 8 [Homo sapiens] 340 1e-93
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 332 6e-91
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 319 3e-87
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 319 3e-87
gi|148664209 kelch-like 10 [Homo sapiens] 314 1e-85
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 280 3e-75
gi|40018614 DRE1 protein [Homo sapiens] 277 1e-74
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 265 7e-71
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 265 7e-71
gi|223890235 intracisternal A particle-promoted polypeptide isof... 260 2e-69
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 247 2e-65
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 247 2e-65
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 225 8e-59
gi|45643138 kelch-like 13 [Homo sapiens] 221 9e-58
gi|24308181 kelch-like 9 [Homo sapiens] 221 1e-57
gi|109150407 kelch-like 6 [Homo sapiens] 219 4e-57
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 1016 bits (2628), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240
SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240
Query: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 300
KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD
Sbjct: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 300
Query: 301 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 360
RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL
Sbjct: 301 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 360
Query: 361 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 420
LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL
Sbjct: 361 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 420
Query: 421 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 480
VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD
Sbjct: 421 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 480
Query: 481 KWTVVSSCMSTGRSYAGVTVIDKPL 505
KWTVVSSCMSTGRSYAGVTVIDKPL
Sbjct: 481 KWTVVSSCMSTGRSYAGVTVIDKPL 505
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 1016 bits (2628), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF
Sbjct: 93 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 152
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS
Sbjct: 153 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 212
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS
Sbjct: 213 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 272
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240
SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF
Sbjct: 273 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 332
Query: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 300
KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD
Sbjct: 333 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 392
Query: 301 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 360
RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL
Sbjct: 393 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 452
Query: 361 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 420
LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL
Sbjct: 453 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 512
Query: 421 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 480
VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD
Sbjct: 513 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 572
Query: 481 KWTVVSSCMSTGRSYAGVTVIDKPL 505
KWTVVSSCMSTGRSYAGVTVIDKPL
Sbjct: 573 KWTVVSSCMSTGRSYAGVTVIDKPL 597
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 1016 bits (2628), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF
Sbjct: 89 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 148
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS
Sbjct: 149 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 208
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS
Sbjct: 209 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 268
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240
SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF
Sbjct: 269 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 328
Query: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 300
KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD
Sbjct: 329 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 388
Query: 301 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 360
RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL
Sbjct: 389 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448
Query: 361 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 420
LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL
Sbjct: 449 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 508
Query: 421 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 480
VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD
Sbjct: 509 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 568
Query: 481 KWTVVSSCMSTGRSYAGVTVIDKPL 505
KWTVVSSCMSTGRSYAGVTVIDKPL
Sbjct: 569 KWTVVSSCMSTGRSYAGVTVIDKPL 593
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 835 bits (2157), Expect = 0.0
Identities = 401/505 (79%), Positives = 459/505 (90%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
MSES+AK++ IK+VDG TL LIDY+YTAEI+VTEENVQVLLPAA LLQL DV++ CC+F
Sbjct: 83 MSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDF 142
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L+SQLHP NCLGIRAFAD+H CTDLL +AN YAEQHF +V+L EEFL+L ++QVCSLISS
Sbjct: 143 LQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISS 202
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
DKLT+SSEEKVFEAVI+W+N++K+ R E MA+LMEHVRLPLLPR+YLVQ VEEEAL+KN+
Sbjct: 203 DKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNN 262
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240
+ CKD+LIEAMKYHLLP +QR+L+K+ RT+ RTP++LPK+M+VVGGQAPKAIRSVECYDF
Sbjct: 263 NTCKDFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDF 322
Query: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 300
+E+RW Q+AELPSRRCRAG+V+MAG V+AVGGFNGSLRVRTVD YD VKDQWTS+A+M++
Sbjct: 323 EEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQE 382
Query: 301 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 360
RRSTLGAAVLN LLYAVGGFDGSTGL+SVEAY+ K+NEWF VAPMNTRRSSVGVGVV G
Sbjct: 383 RRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGK 442
Query: 361 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 420
LYAVGGYDGASRQCLSTVE YN TNEW Y+A+MSTRRSGAGVGVL+ LYA GGHDGPL
Sbjct: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502
Query: 421 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 480
VRKSVEVYDP TN W+QVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNP TD
Sbjct: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTD 562
Query: 481 KWTVVSSCMSTGRSYAGVTVIDKPL 505
KWT++ + MSTGRSYAGV VI K L
Sbjct: 563 KWTLLPTNMSTGRSYAGVAVIHKSL 587
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 467 bits (1202), Expect = e-131
Identities = 248/503 (49%), Positives = 329/503 (65%), Gaps = 5/503 (0%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
MSESR V + ++D L L+ + YTAEI V E NVQ LLPAA LLQL V+ CC+F
Sbjct: 125 MSESRQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKF 184
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L SQL P NCLGIR FAD H+C+DLL A+ Y QHF DV +EEF+ L ++QV L+SS
Sbjct: 185 LLSQLDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSS 244
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
D L + SEE+V+ AV++WV HD D R++ + RLM+ VRLPLL R++L+ V+ E+LV++
Sbjct: 245 DSLNVPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHH 304
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIR-SVECYD 239
CKD LIEA+K+HLLP EQR ++ + RTR R ++ VGG + AI E YD
Sbjct: 305 PDCKDLLIEALKFHLLP-EQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYD 363
Query: 240 FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMR 299
+ +RWH VA + +RR R G+ + ++AVGG++G+ + TV+SYDPV + W +M
Sbjct: 364 TRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMG 423
Query: 300 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 359
RRS LG A L+GLLY+ GG+DG++ L+S E Y+ + W VA M+TRR V V + G
Sbjct: 424 TRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDG 483
Query: 360 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGP 419
LYAVGGYD +S L+TVE Y N W+ +A M +RRS AGV VL LY GG+DG
Sbjct: 484 NLYAVGGYDSSSH--LATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGT 541
Query: 420 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTT 479
SVE Y P AW VA MN+ R + A++G LY VGG+DGS +L S+E YNP T
Sbjct: 542 SCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRT 601
Query: 480 DKWTVVSSCMSTGRSYAGVTVID 502
+KW V +SCM T RS GV V++
Sbjct: 602 NKW-VAASCMFTRRSSVGVAVLE 623
Score = 144 bits (363), Expect = 2e-34
Identities = 80/185 (43%), Positives = 110/185 (59%), Gaps = 2/185 (1%)
Query: 225 GGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDS 284
G + S E YD W VA + +RR + + G ++AVGG++ S + TV+
Sbjct: 443 GYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK 502
Query: 285 YDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAP 344
Y+P + W+ VA+M RRS+ G AVL G LY GG DG++ L+SVE Y+ K+ W VAP
Sbjct: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAP 562
Query: 345 MNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVG 404
MN RRS+ + + G LYAVGG DG+S L+++E YN TN+W + M TRRS GV
Sbjct: 563 MNIRRSTHDLVAMDGWLYAVGGNDGSSS--LNSIEKYNPRTNKWVAASCMFTRRSSVGVA 620
Query: 405 VLNNL 409
VL L
Sbjct: 621 VLELL 625
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 412 bits (1060), Expect = e-115
Identities = 227/503 (45%), Positives = 314/503 (62%), Gaps = 6/503 (1%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
++ESR V I+++D + +LID+ YT++I V E NVQ LLPAA LLQL ++++ CCEF
Sbjct: 101 LAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEF 160
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L+ QL P NCLGIRAFAD H+C +LL A+ + + +F +V+ SEEF+ L Q+ +ISS
Sbjct: 161 LKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISS 220
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
D+L + SEE+VF AV+AWV + R+ + ++++HVRLPLL ++LV V + L+K+
Sbjct: 221 DELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSD 280
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQ-APKAIRSVECYD 239
C+D + EA Y LLP ++R LM+ RTR R P+ +++ VGG + AI SVE YD
Sbjct: 281 EECRDLVDEAKNYLLLP-QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYD 339
Query: 240 FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTS-VANM 298
+ W VA + RRC G+ + L++AVGG +GS + +V+ YDP +QW+S VA
Sbjct: 340 PQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPT 399
Query: 299 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
R+++G AVL G LYAVGG DG + L+ VE Y+ K N+W VA M+TRR V V V+G
Sbjct: 400 STCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLG 459
Query: 359 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 418
G LYAVGG DG S L+TVE YN N W IA M TRR G V +++YAVGG D
Sbjct: 460 GFLYAVGGSDGTSP--LNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDD 517
Query: 419 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 478
S E Y+P TN W V M R G+ VNG L VGG DG+ L ++E ++P
Sbjct: 518 TTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPD 577
Query: 479 TDKWTVVSSCMSTGRSYAGVTVI 501
+ W + M+ R GV VI
Sbjct: 578 ANTWRLYGG-MNYRRLGGGVGVI 599
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 393 bits (1010), Expect = e-109
Identities = 208/505 (41%), Positives = 311/505 (61%), Gaps = 12/505 (2%)
Query: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
E+R + ++++ V+ +L LI Y YT +++ E+N++ LL A LLQL V + CC+FL
Sbjct: 209 EARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLM 268
Query: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
QLHP NCLGIR+FAD CTDL A+ Y +HF +V+ ++EF+ L ++ L++SD
Sbjct: 269 KQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDD 328
Query: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
+ I +EE + A++ WV HD + R++ +++L+ ++RLPLL ++L +E L ++
Sbjct: 329 MNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIE 387
Query: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242
C+ ++EAMKYHLLP E+R +++S RT+ R + L V G + K S+E YD +
Sbjct: 388 CQKLIMEAMKYHLLP-ERRPMLQSPRTKPR-KSTVGTLFAVGGMDSTKGATSIEKYDLRT 445
Query: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302
W VA + RR + G+ + ++ VGG +G + TV+ Y+P W+ + M R
Sbjct: 446 NMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHR 505
Query: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
LG AVL G +YAVGG DG + L++VE ++ ++ +W VA M+T RS+VGV V+ G LY
Sbjct: 506 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 565
Query: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420
AVGG DG+S CL +VEC++ TN+WT A+MS RR G GV N LLYA+GGHD P
Sbjct: 566 AVGGRDGSS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 623
Query: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
+ VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+
Sbjct: 624 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYD 683
Query: 477 PTTDKWTVVSSCMSTGRSYAGVTVI 501
P T++WT V+ + GR+ A V +
Sbjct: 684 PQTNEWTQVAP-LCLGRAGACVVTV 707
Score = 35.8 bits (81), Expect = 0.094
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 455 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 505
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 470
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 393 bits (1010), Expect = e-109
Identities = 208/505 (41%), Positives = 311/505 (61%), Gaps = 12/505 (2%)
Query: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
E+R + ++++ V+ +L LI Y YT +++ E+N++ LL A LLQL V + CC+FL
Sbjct: 194 EARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLM 253
Query: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
QLHP NCLGIR+FAD CTDL A+ Y +HF +V+ ++EF+ L ++ L++SD
Sbjct: 254 KQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDD 313
Query: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
+ I +EE + A++ WV HD + R++ +++L+ ++RLPLL ++L +E L ++
Sbjct: 314 MNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIE 372
Query: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242
C+ ++EAMKYHLLP E+R +++S RT+ R + L V G + K S+E YD +
Sbjct: 373 CQKLIMEAMKYHLLP-ERRPMLQSPRTKPR-KSTVGTLFAVGGMDSTKGATSIEKYDLRT 430
Query: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302
W VA + RR + G+ + ++ VGG +G + TV+ Y+P W+ + M R
Sbjct: 431 NMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHR 490
Query: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
LG AVL G +YAVGG DG + L++VE ++ ++ +W VA M+T RS+VGV V+ G LY
Sbjct: 491 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 550
Query: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420
AVGG DG+S CL +VEC++ TN+WT A+MS RR G GV N LLYA+GGHD P
Sbjct: 551 AVGGRDGSS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 608
Query: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
+ VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+
Sbjct: 609 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYD 668
Query: 477 PTTDKWTVVSSCMSTGRSYAGVTVI 501
P T++WT V+ + GR+ A V +
Sbjct: 669 PQTNEWTQVAP-LCLGRAGACVVTV 692
Score = 35.8 bits (81), Expect = 0.094
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 455 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 505
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 455
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 393 bits (1010), Expect = e-109
Identities = 208/505 (41%), Positives = 311/505 (61%), Gaps = 12/505 (2%)
Query: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
E+R + ++++ V+ +L LI Y YT +++ E+N++ LL A LLQL V + CC+FL
Sbjct: 255 EARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLM 314
Query: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
QLHP NCLGIR+FAD CTDL A+ Y +HF +V+ ++EF+ L ++ L++SD
Sbjct: 315 KQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDD 374
Query: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
+ I +EE + A++ WV HD + R++ +++L+ ++RLPLL ++L +E L ++
Sbjct: 375 MNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIE 433
Query: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242
C+ ++EAMKYHLLP E+R +++S RT+ R + L V G + K S+E YD +
Sbjct: 434 CQKLIMEAMKYHLLP-ERRPMLQSPRTKPR-KSTVGTLFAVGGMDSTKGATSIEKYDLRT 491
Query: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302
W VA + RR + G+ + ++ VGG +G + TV+ Y+P W+ + M R
Sbjct: 492 NMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHR 551
Query: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
LG AVL G +YAVGG DG + L++VE ++ ++ +W VA M+T RS+VGV V+ G LY
Sbjct: 552 HGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLY 611
Query: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420
AVGG DG+S CL +VEC++ TN+WT A+MS RR G GV N LLYA+GGHD P
Sbjct: 612 AVGGRDGSS--CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASN 669
Query: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
+ VE YDP T+ W VA M++ R GVC + LY VGG DG L +VE Y+
Sbjct: 670 LTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYD 729
Query: 477 PTTDKWTVVSSCMSTGRSYAGVTVI 501
P T++WT V+ + GR+ A V +
Sbjct: 730 PQTNEWTQVAP-LCLGRAGACVVTV 753
Score = 35.8 bits (81), Expect = 0.094
Identities = 20/51 (39%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 455 GLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 505
G L+ VGG D + S+E Y+ T+ WT V++ M+ R GV V+D L
Sbjct: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVAN-MNGRRLQFGVAVLDDKL 516
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 380 bits (976), Expect = e-105
Identities = 213/508 (41%), Positives = 302/508 (59%), Gaps = 15/508 (2%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
+SE V I+ + T+ +L+D+VYT + VT ENVQ LLPAA LLQL+ VK+ CCEF
Sbjct: 66 LSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEF 125
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
LESQL P NCLGIR FA+ H C DL+ A ++++HF +VV EEF+ L +V LI
Sbjct: 126 LESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKC 185
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
D++ + SEE VFEAVI WV H K R+E + L+++VR+PLL Y+ ++ E ++ S
Sbjct: 186 DEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCS 245
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG----QAPKAIRSVE 236
C+D + EA K+HL P E R M+ RTR R N ++++VVGG Q+P I VE
Sbjct: 246 LQCRDLVDEAKKFHLRP-ELRSQMQGPRTRARLGAN--EVLLVVGGFGSQQSP--IDVVE 300
Query: 237 CYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQ---WT 293
YD K + W + + +R V + ++ +GG++G R+ +V+ D D+ W
Sbjct: 301 KYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWY 360
Query: 294 SVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVG 353
SVA M RR GA L ++Y GGFDGS +S+E Y+ ++W + M T R G
Sbjct: 361 SVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAG 420
Query: 354 VGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAV 413
+ V G++Y +GGYDG + L++VE Y+ T WT + M+T+RSGAGV +LN+ +Y V
Sbjct: 421 LVVASGVIYCLGGYDGLN--ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVV 478
Query: 414 GGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVE 473
GG DG SVE Y+ T++W V M R G + G LY + G DG+ L+S+E
Sbjct: 479 GGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIE 538
Query: 474 YYNPTTDKWTVVSSCMSTGRSYAGVTVI 501
Y+P D W VV+S M T R AGV V+
Sbjct: 539 CYDPIIDSWEVVTS-MGTQRCDAGVCVL 565
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 369 bits (946), Expect = e-102
Identities = 203/508 (39%), Positives = 301/508 (59%), Gaps = 12/508 (2%)
Query: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
E++ + ++++ +D L L+ + YT +++ E+ ++ LL AA LLQL V + CC FL
Sbjct: 247 EAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLM 306
Query: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
LHP NCLGIRAFAD C +L+ A++Y ++ +V+ ++EFL L E++ L++SD
Sbjct: 307 KLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDD 366
Query: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
+ + EE +F A++ WV +D R ++ L+ +RLPLLP + L +E AL KN
Sbjct: 367 VNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQILAD-LENHALFKNDLE 425
Query: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242
C+ ++EAMKYHLLP E+R LM+S RT+ R + L V G K ++E YD +
Sbjct: 426 CQKLILEAMKYHLLP-ERRTLMQSPRTKPR-KSTVGTLYAVGGMDNNKGATTIEKYDLRT 483
Query: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302
W Q + RR + G+ + +F +GG +G + TV+ Y+P WT + M R
Sbjct: 484 NLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHR 543
Query: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
LG VL G +YAVGG DG + L++VE ++ +S +W VA M+ RS+VGV + G LY
Sbjct: 544 HGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLY 603
Query: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420
+VGG DG+S CLS++E Y+ TN+W A M RR G GV + LYAVGGHD P
Sbjct: 604 SVGGRDGSS--CLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASN 661
Query: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
+ VE YDP T+ W VA ++M R GVC + LY VGG DG L ++E Y+
Sbjct: 662 HCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYD 721
Query: 477 PTTDKWTVVSSCMSTGRSYAGVTVIDKP 504
P T++WT ++S ++ GR+ A V VI +P
Sbjct: 722 PQTNEWTQMAS-LNIGRAGACVVVIKQP 748
Score = 78.2 bits (191), Expect = 2e-14
Identities = 44/96 (45%), Positives = 55/96 (57%), Gaps = 1/96 (1%)
Query: 410 LYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNL 469
LYAVGG D ++E YD TN W Q MN R GV ++ L+V+GG DG L
Sbjct: 461 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTL 520
Query: 470 ASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 505
+VE YNP T WTV+ MST R GVTV++ P+
Sbjct: 521 NTVECYNPKTKTWTVLPP-MSTHRHGLGVTVLEGPI 555
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 368 bits (945), Expect = e-102
Identities = 190/488 (38%), Positives = 289/488 (59%), Gaps = 5/488 (1%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
M E + + ++ +D L LI++ Y + + ++NVQ LL A LQLQ +K CC F
Sbjct: 71 MMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTF 130
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L +LHP NCLG+R FA+ C L + AN++ QHF +V +SEEFL L +E V L+S
Sbjct: 131 LRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSR 190
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
D+L + SEE+VFEA +AWV +D++ R ++ L+ ++RLPL ++L RV+++ LV+
Sbjct: 191 DELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCC 250
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECY 238
C+D + EA YHL+P E+R + + RTR R ++ L+ VGG A ++ VE +
Sbjct: 251 HKCRDLVDEAKDYHLMP-ERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVF 309
Query: 239 DFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANM 298
D W + + + R R G+ + GL++A+GG++G LR+ TV++Y+P D WT V +M
Sbjct: 310 DPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSM 369
Query: 299 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
+RS +G VL+G +Y GG+DG++ LSSVE Y+ ++++W V M++ RS+ GV V
Sbjct: 370 NSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFE 429
Query: 359 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 418
G +Y GG+DG Q S+VE YN T W A M +R G L + ++ GG+DG
Sbjct: 430 GRIYVSGGHDGL--QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDG 487
Query: 419 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 478
E+Y + W + M+ R + A G LY VGG DG NL+SVE Y+P
Sbjct: 488 SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPE 547
Query: 479 TDKWTVVS 486
TD WT ++
Sbjct: 548 TDCWTFMA 555
Score = 136 bits (342), Expect = 5e-32
Identities = 71/146 (48%), Positives = 95/146 (65%), Gaps = 2/146 (1%)
Query: 357 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 416
+ GL+YAVGG + A L+ VE ++ N W M+T RS GV V+N LLYA+GG+
Sbjct: 286 IAGLIYAVGGLNSAG-DSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY 344
Query: 417 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
DG L +VE Y+P T+ W +V MN R G ++G +YV GG DG+ +L+SVE Y+
Sbjct: 345 DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYS 404
Query: 477 PTTDKWTVVSSCMSTGRSYAGVTVID 502
P TDKWTVV+S MS+ RS AGVTV +
Sbjct: 405 PETDKWTVVTS-MSSNRSAAGVTVFE 429
Score = 127 bits (318), Expect = 3e-29
Identities = 72/203 (35%), Positives = 109/203 (53%), Gaps = 2/203 (0%)
Query: 204 MKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYM 263
M S R+ + T + ++ V G ++ SVE Y + ++W V + S R AG+
Sbjct: 369 MNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVF 428
Query: 264 AGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGS 323
G ++ GG +G +V+ Y+ W A M ++R GAA L ++ GG+DGS
Sbjct: 429 EGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGS 488
Query: 324 TGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNA 383
LS E Y+ +++W + PM+TRRS V + G LYAVGGYDG S LS+VE Y+
Sbjct: 489 GFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSN--LSSVEMYDP 546
Query: 384 TTNEWTYIAEMSTRRSGAGVGVL 406
T+ WT++A M+ G GVG +
Sbjct: 547 ETDCWTFMAPMACHEGGVGVGCI 569
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 359 bits (922), Expect = 3e-99
Identities = 200/508 (39%), Positives = 293/508 (57%), Gaps = 12/508 (2%)
Query: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
E++ + VR++ VD L L+ Y YT +Q+ E+ ++ LL AA LLQL V C FL
Sbjct: 217 EAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLI 276
Query: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
QLHP NCLGIR+F D CT+LLN A+ Y +HF +V+ ++EFL L ++ L+ SD
Sbjct: 277 KQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDD 336
Query: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
+ + EE +F A++ WV HD RQ + L+ ++RLPLLP + L +E ++
Sbjct: 337 INVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLE 395
Query: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242
C+ L+EAMKYHLLP E+R +M+S RT+ R + L V G A K ++E YD +
Sbjct: 396 CQKLLMEAMKYHLLP-ERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRT 453
Query: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302
W + + RR + G+ + ++ VGG +G + TV+ ++PV WT + M R
Sbjct: 454 NSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHR 513
Query: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
LG A L G +YAVGG DG + L++VE ++ + +W +VA M+T RS+VGV + LY
Sbjct: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
Query: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420
A+GG DG+S CL ++E ++ TN+W+ A MS RR G GV N LY VGGHD P
Sbjct: 574 AIGGRDGSS--CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASN 631
Query: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
+ VE YDP ++W VA +++ R VC + LYVVGG DG L +VE Y+
Sbjct: 632 HCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYD 691
Query: 477 PTTDKWTVVSSCMSTGRSYAGVTVIDKP 504
++W ++ GR+ A V V+ P
Sbjct: 692 AQRNEWK-EEVPVNIGRAGACVVVVKLP 718
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 357 bits (916), Expect = 1e-98
Identities = 194/486 (39%), Positives = 283/486 (58%), Gaps = 11/486 (2%)
Query: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
E++ + VR++ VD L L+ Y YT +Q+ E+ ++ LL AA LLQL V C FL
Sbjct: 217 EAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLI 276
Query: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
QLHP NCLGIR+F D CT+LLN A+ Y +HF +V+ ++EFL L ++ L+ SD
Sbjct: 277 KQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDD 336
Query: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
+ + EE +F A++ WV HD RQ + L+ ++RLPLLP + L +E ++
Sbjct: 337 INVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLAD-LETSSMFTGDLE 395
Query: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKE 242
C+ L+EAMKYHLLP E+R +M+S RT+ R + L V G A K ++E YD +
Sbjct: 396 CQKLLMEAMKYHLLP-ERRSMMQSPRTKPR-KSTVGALYAVGGMDAMKGTTTIEKYDLRT 453
Query: 243 ERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRR 302
W + + RR + G+ + ++ VGG +G + TV+ ++PV WT + M R
Sbjct: 454 NSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHR 513
Query: 303 STLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLY 362
LG A L G +YAVGG DG + L++VE ++ + +W +VA M+T RS+VGV + LY
Sbjct: 514 HGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLY 573
Query: 363 AVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL-- 420
A+GG DG+S CL ++E ++ TN+W+ A MS RR G GV N LY VGGHD P
Sbjct: 574 AIGGRDGSS--CLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASN 631
Query: 421 ----VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
+ VE YDP ++W VA +++ R VC + LYVVGG DG L +VE Y+
Sbjct: 632 HCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYD 691
Query: 477 PTTDKW 482
++W
Sbjct: 692 AQRNEW 697
Score = 168 bits (426), Expect = 9e-42
Identities = 89/200 (44%), Positives = 118/200 (59%), Gaps = 9/200 (4%)
Query: 299 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
+ R+ST+GA LYAVGG D G +++E Y++++N W H+ MN RR GV V+
Sbjct: 422 KPRKSTVGA------LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVID 475
Query: 359 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 418
LY VGG DG + L+TVEC+N WT + MST R G GV L +YAVGGHDG
Sbjct: 476 NKLYVVGGRDGL--KTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDG 533
Query: 419 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 478
+VE +DP W VA M+ R GV A+N LY +GG DGS L S+EY++P
Sbjct: 534 WSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPH 593
Query: 479 TDKWTVVSSCMSTGRSYAGV 498
T+KW++ + MS R GV
Sbjct: 594 TNKWSLCAP-MSKRRGGVGV 612
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 340 bits (873), Expect = 1e-93
Identities = 183/502 (36%), Positives = 294/502 (58%), Gaps = 5/502 (0%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
M+E++ + I++ DG + L+ +VY++ + +T +NVQ LL AA +LQ++ V + CCE+
Sbjct: 100 MAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEY 159
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
++ HP NCL +RAFA+ H DL++ A+ YA HF +VV E+F+++ + + L+SS
Sbjct: 160 MKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSS 219
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
L I +E++V+ A I W+ + +++ + VRLPLLP ++L+ V +E +VK +
Sbjct: 220 SDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQN 279
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKA--IRSVECY 238
C+D L EA YHL + + + R + ++ VGG+ RS+ECY
Sbjct: 280 LKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECY 339
Query: 239 DFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANM 298
+ W E+ SRR G++ + G V+AVGG +G+ + +++ +DP+ ++W A+M
Sbjct: 340 SINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASM 399
Query: 299 RDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
+R + A L G +YA+GG D +T + VE Y+I+S++W VAPMNT R VG +
Sbjct: 400 NTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALV 459
Query: 359 GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDG 418
+YAVGG DG + LS+VE Y+ ++W + EM RR+G GV L+ LY VGG D
Sbjct: 460 NHVYAVGGNDGMA--SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDD 517
Query: 419 PLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPT 478
SVE YDP +N W VA + R G+ V G ++ VGG +G+ L +VE ++P
Sbjct: 518 NSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPV 577
Query: 479 TDKWTVVSSCMSTGRSYAGVTV 500
++W +V S +S R+ AGV V
Sbjct: 578 LNRWELVGS-VSHCRAGAGVAV 598
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 332 bits (850), Expect = 6e-91
Identities = 183/492 (37%), Positives = 280/492 (56%), Gaps = 16/492 (3%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
+SE V + +D L+ +++Y YT + ++++ V+ LLPAA LLQ++ V K CC F
Sbjct: 68 LSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAF 127
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
LESQL P NC+GI FA+ + C DL A Y Q+F V +EEF L + ++S+
Sbjct: 128 LESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSN 187
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
D L +++EE VF A+ +W+ +D RQ+++A+L+ VRLPLL ++L + E L+++
Sbjct: 188 DCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDD 247
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAP--KAIRSVECY 238
CK L EA+KYH +P E R+ ++V + P PK++ VGG++ + SVE Y
Sbjct: 248 RTCKHLLNEALKYHFMP-EHRLSHQTV--LMTRPRCAPKVLCAVGGKSGLFACLDSVEMY 304
Query: 239 DFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR--------VRTVDSYDPVKD 290
+ + W +A L R G+ + V+ +GG ++R +V+ ++P +
Sbjct: 305 FPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTN 364
Query: 291 QWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRS 350
WTS+ M + RSTLG VL G LYA+GG+DG + L SVE Y K +W VAPM T RS
Sbjct: 365 TWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRS 424
Query: 351 SVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLL 410
V+ G++YA+GGY A +++VE Y+ + + W +A M+ +R GVGV+ +
Sbjct: 425 CFAAAVLDGMIYAIGGYGPAH---MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFI 481
Query: 411 YAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLA 470
+ VGGH+G S+E YDP N W M R G ++ LYVVGG GS L
Sbjct: 482 FVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLN 541
Query: 471 SVEYYNPTTDKW 482
+V+ Y+P +D W
Sbjct: 542 TVQKYDPISDTW 553
Score = 101 bits (252), Expect = 1e-21
Identities = 50/138 (36%), Positives = 80/138 (57%)
Query: 217 LPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGS 276
L ++ +GG P + SVE YD ++ W VA + +R G+ M G +F VGG NG
Sbjct: 431 LDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGV 490
Query: 277 LRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKS 336
+ +++ YDP ++QWT M++ R+ +GAAV++ LY VGG GS+ L++V+ Y+ S
Sbjct: 491 SHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPIS 550
Query: 337 NEWFHVAPMNTRRSSVGV 354
+ W A M R + G+
Sbjct: 551 DTWLDSAGMIYCRCNFGL 568
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 319 bits (818), Expect = 3e-87
Identities = 189/508 (37%), Positives = 279/508 (54%), Gaps = 14/508 (2%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
+ E + V I+ + + LI++ YTA I + E+ V ++ A + Q+ V + C +F
Sbjct: 115 LREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L QL P N +GI FA+ C +L +A Y HF +V EEF NL Q+ +LIS
Sbjct: 175 LVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISR 234
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
D L + E +VF A I WV +D + R+ ++ L+ VR L +L ++++ ++++
Sbjct: 235 DDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSD 294
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240
S CKDYL++ E+ L K + + +L+ GG +++ +E Y+
Sbjct: 295 SRCKDYLVKIF-------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNP 347
Query: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN----GSLRVRTVDSYDPVKDQWTSVA 296
+ W ++A+L R + GL++AVGG N G+ +D Y+P+ +QW+ A
Sbjct: 348 SDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCA 407
Query: 297 NMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGV 356
M R+ +G V++G +YAVGG G +SVE Y + +EW VAPM TRR VGV V
Sbjct: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
Query: 357 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 416
+ LLYAVGG+DG +R L++ ECY NEW I M+T RSGAGV VL+N +YA GG+
Sbjct: 468 LNRLLYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525
Query: 417 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
DG SVE YD T W VA M R G+ G +YV+GG DG L SVE Y+
Sbjct: 526 DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYD 585
Query: 477 PTTDKWTVVSSCMSTGRSYAGVTVIDKP 504
P TD W+ V+ M++GRS GV V +P
Sbjct: 586 PDTDTWSEVTR-MTSGRSGVGVAVTMEP 612
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 319 bits (818), Expect = 3e-87
Identities = 189/508 (37%), Positives = 279/508 (54%), Gaps = 14/508 (2%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
+ E + V I+ + + LI++ YTA I + E+ V ++ A + Q+ V + C +F
Sbjct: 115 LREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L QL P N +GI FA+ C +L +A Y HF +V EEF NL Q+ +LIS
Sbjct: 175 LVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISR 234
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
D L + E +VF A I WV +D + R+ ++ L+ VR L +L ++++ ++++
Sbjct: 235 DDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSD 294
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240
S CKDYL++ E+ L K + + +L+ GG +++ +E Y+
Sbjct: 295 SRCKDYLVKIF-------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNP 347
Query: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN----GSLRVRTVDSYDPVKDQWTSVA 296
+ W ++A+L R + GL++AVGG N G+ +D Y+P+ +QW+ A
Sbjct: 348 SDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCA 407
Query: 297 NMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGV 356
M R+ +G V++G +YAVGG G +SVE Y + +EW VAPM TRR VGV V
Sbjct: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
Query: 357 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 416
+ LLYAVGG+DG +R L++ ECY NEW I M+T RSGAGV VL+N +YA GG+
Sbjct: 468 LNRLLYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525
Query: 417 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
DG SVE YD T W VA M R G+ G +YV+GG DG L SVE Y+
Sbjct: 526 DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYD 585
Query: 477 PTTDKWTVVSSCMSTGRSYAGVTVIDKP 504
P TD W+ V+ M++GRS GV V +P
Sbjct: 586 PDTDTWSEVTR-MTSGRSGVGVAVTMEP 612
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 314 bits (805), Expect = 1e-85
Identities = 172/469 (36%), Positives = 259/469 (55%), Gaps = 9/469 (1%)
Query: 19 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 78
++++I+Y YT + +T +NV+ LL AA + + + CCEFL+S+L NC+GI F D
Sbjct: 90 MKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTD 149
Query: 79 MHACTDLLNKANTYAEQHFADVV-LSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIA 137
+ C +L KA + +F ++V +S EFL L + ++ +I D+L + E+ VFEA++
Sbjct: 150 YYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILK 209
Query: 138 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMK--YHL 195
W++HD R++ ++ L+ VRL L+ EY + V+ VK+S CK +I A+K Y L
Sbjct: 210 WISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDL 269
Query: 196 -LPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVA-ELPS 253
+ + TR R P + L + G ++E YD + +RW V E S
Sbjct: 270 NMNGPSNSDFTNPLTRPRLPYAI--LFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEES 327
Query: 254 RRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGL 313
R G Y+ G V+ +GGF+ +V +DPVK W VA M RR + VL
Sbjct: 328 PRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNF 387
Query: 314 LYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 373
+YA+GGFDG L++ E Y ++N+W +APM+ +RS + G +Y GG++G +
Sbjct: 388 IYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNG--NE 445
Query: 374 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTN 433
CL T E YN +N+WT IA M +RRSG GV +YAVGG DG +S E Y P N
Sbjct: 446 CLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVAN 505
Query: 434 AWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 482
WR + M R N G+ V+ LL+VVGG +G +VE Y+ TD+W
Sbjct: 506 TWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEW 554
Score = 114 bits (284), Expect = 3e-25
Identities = 61/187 (32%), Positives = 107/187 (57%), Gaps = 4/187 (2%)
Query: 313 LLYAVGGFDGSTGLSSVEAYNIKSNEWFHVA-PMNTRRSSVGVGVVGGLLYAVGGYDGAS 371
+L+A+GG+ G + +++EAY+ +++ W +V + R+ G + G +Y +GG+D S
Sbjct: 292 ILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFD--S 349
Query: 372 RQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPT 431
++V+ ++ W +A M +RR V VL N +YA+GG DG + + E Y+P
Sbjct: 350 VDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPE 409
Query: 432 TNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMST 491
TN W +A M+ R +A + G +Y+ GG +G+ L + E YN +++WTV++ M +
Sbjct: 410 TNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAP-MRS 468
Query: 492 GRSYAGV 498
RS GV
Sbjct: 469 RRSGIGV 475
Score = 99.4 bits (246), Expect = 7e-21
Identities = 49/142 (34%), Positives = 84/142 (59%)
Query: 219 KLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLR 278
K+ + G + + + E Y+ + +W +A + SRR G++ V+AVGGF+G+ R
Sbjct: 434 KVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANR 493
Query: 279 VRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNE 338
+R+ ++Y PV + W ++ M + RS G V++ LL+ VGGF+G T +VE Y+ K++E
Sbjct: 494 LRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDE 553
Query: 339 WFHVAPMNTRRSSVGVGVVGGL 360
W+ M+ RS++ VV GL
Sbjct: 554 WYDAHDMSIYRSALSCCVVPGL 575
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 280 bits (715), Expect = 3e-75
Identities = 172/517 (33%), Positives = 268/517 (51%), Gaps = 18/517 (3%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
M ES V I ++ ++L+D++YT + + NVQ L+ AA +LQL +V CCEF
Sbjct: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L+ Q+ P+NC+GI F++ AC DLL + Y HF +V EEFL L +Q+ ++ S
Sbjct: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
++L+I E +VF A + W+ D R++ + +++ +R PLLP + L++ +E +
Sbjct: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA---------PKA 231
A + L E + P E + +++R K + VGG +A
Sbjct: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
Query: 232 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQ 291
+ VE +D + W V+ L R G+ + G+V+A+GG S+ + YDPV Q
Sbjct: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
Query: 292 WTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSS 351
WT+VA+M R LG V G +YA+GG+ G+ +++E ++ N+W V M R
Sbjct: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429
Query: 352 VGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLY 411
G + GL+Y +GG + L + E Y+ + W+ + M TRR+ GV LN+ +Y
Sbjct: 430 FGCCEMQGLIYVIGGISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIY 488
Query: 412 AVGG-HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN-- 468
+VGG ++ +VE Y W +VA M + R V AVNGLLYV GG S +
Sbjct: 489 SVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFL 548
Query: 469 ----LASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVI 501
L SVE YNP +D WT + + M T R GV V+
Sbjct: 549 APGTLDSVEVYNPHSDTWTEIGN-MITSRCEGGVAVL 584
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 277 bits (709), Expect = 1e-74
Identities = 182/506 (35%), Positives = 251/506 (49%), Gaps = 19/506 (3%)
Query: 3 ESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLE 62
ESR V I + + + YVYT ++++T ENVQ L + L Q+ ++ C +FLE
Sbjct: 101 ESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLE 160
Query: 63 SQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDK 122
QL P NCLGI+ FAD H+ L K +A Q F DV EEFL L +++ I SD+
Sbjct: 161 EQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDE 220
Query: 123 LTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSA 182
L I EE VFEAV+ WV D+R+ + L+ HVRLPLL Y VQ VE + L++NS
Sbjct: 221 LVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPE 280
Query: 183 CKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKA---IRSVECYD 239
C L EA +YH+L E M S RTR R +++VVVGG + ECYD
Sbjct: 281 CYQLLHEARRYHILGNE----MMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYD 336
Query: 240 FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMR 299
W +A+LP V V G G + R V Y+ + W VA++
Sbjct: 337 PVTGEWKSLAKLPEFTKSEYAVCALRNDILVSG--GRINSRDVWIYNSQLNIWIRVASLN 394
Query: 300 DRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGG 359
R AVL G +Y VGG+DG LSSVE Y+ SN W VAP+ SS V G
Sbjct: 395 KGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVG 454
Query: 360 LLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGP 419
L+ +GG C V+ Y+ TN W A + + LNNL+Y GG
Sbjct: 455 KLFVIGG-GPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGG---- 509
Query: 420 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG--DDGSCNLASVEYYNP 477
+ K++ YDP + W V + + N G+ NG +Y++GG ++G ++ Y+P
Sbjct: 510 -LTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEAT-DTILCYDP 567
Query: 478 TTDKWTVVSSCMSTGRSYAGVTVIDK 503
T T V++ M SY G I +
Sbjct: 568 ATSIITGVAA-MPRPVSYHGCVTIHR 592
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 265 bits (677), Expect = 7e-71
Identities = 157/506 (31%), Positives = 261/506 (51%), Gaps = 11/506 (2%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
M ES++ V +K+ + + L+++ YTA I V NVQ LL AA Q++ VKK C +F
Sbjct: 77 MLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDF 136
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L+ Q+ NCLGI A+ C +L A+ + QHF +V ++EFL L +++V L++
Sbjct: 137 LKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQ 196
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
D LT+ +E++V++A + W+ +D+ RQ FM ++ VR PL+ + +L + V+ E L++++
Sbjct: 197 DTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDN 256
Query: 181 SACKDYLIEAMKYHLL-PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYD 239
C +I M+YHLL P ++ L+ R R + + + GG P++ R ++
Sbjct: 257 PECLKMVISGMRYHLLSPEDREELVDGTRPRRK---KHDYRIALFGGSQPQSCR---YFN 310
Query: 240 FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMR 299
K+ W + +R A V+ +V+ +GG + ++ +D Y+ VKD W S
Sbjct: 311 PKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPP 369
Query: 300 DRRSTLGAAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
R +L A G +Y GG + G++ L E Y+ ++ W M T+R S G+
Sbjct: 370 TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEAN 429
Query: 359 GLLYAVGGYDG--ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 416
GL+Y GG G S + L++ E Y+ T WT + M R G+ + + ++AVGG
Sbjct: 430 GLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQ 489
Query: 417 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
+G +VE YD N W+ V+ M AV ++YV+ G G L + YN
Sbjct: 490 NGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 549
Query: 477 PTTDKWTVVSSCMSTGRSYAGVTVID 502
TDKW S + + + V+D
Sbjct: 550 TETDKWVANSKVRAFPVTSCLICVVD 575
Score = 63.5 bits (153), Expect = 4e-10
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 11/195 (5%)
Query: 315 YAVGGFDGSTGLSSVEAYNIKSNEWFHV-APMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 373
Y + F GS S +N K W + P RR + V ++Y +GG +
Sbjct: 293 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 347
Query: 374 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRKSVEVYDPTT 432
+ ++CYN + W T R +Y GG + G E YD T
Sbjct: 348 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 407
Query: 433 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPTTDKWTVVSSC 488
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT +
Sbjct: 408 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 467
Query: 489 MSTGRSYAGVTVIDK 503
+ +++ V V DK
Sbjct: 468 IEARKNHGLVFVKDK 482
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 265 bits (677), Expect = 7e-71
Identities = 157/506 (31%), Positives = 261/506 (51%), Gaps = 11/506 (2%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
M ES++ V +K+ + + L+++ YTA I V NVQ LL AA Q++ VKK C +F
Sbjct: 55 MLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDF 114
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L+ Q+ NCLGI A+ C +L A+ + QHF +V ++EFL L +++V L++
Sbjct: 115 LKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQ 174
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
D LT+ +E++V++A + W+ +D+ RQ FM ++ VR PL+ + +L + V+ E L++++
Sbjct: 175 DTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDN 234
Query: 181 SACKDYLIEAMKYHLL-PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYD 239
C +I M+YHLL P ++ L+ R R + + + GG P++ R ++
Sbjct: 235 PECLKMVISGMRYHLLSPEDREELVDGTRPRRK---KHDYRIALFGGSQPQSCR---YFN 288
Query: 240 FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMR 299
K+ W + +R A V+ +V+ +GG + ++ +D Y+ VKD W S
Sbjct: 289 PKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPP 347
Query: 300 DRRSTLGAAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
R +L A G +Y GG + G++ L E Y+ ++ W M T+R S G+
Sbjct: 348 TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEAN 407
Query: 359 GLLYAVGGYDG--ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 416
GL+Y GG G S + L++ E Y+ T WT + M R G+ + + ++AVGG
Sbjct: 408 GLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQ 467
Query: 417 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
+G +VE YD N W+ V+ M AV ++YV+ G G L + YN
Sbjct: 468 NGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 527
Query: 477 PTTDKWTVVSSCMSTGRSYAGVTVID 502
TDKW S + + + V+D
Sbjct: 528 TETDKWVANSKVRAFPVTSCLICVVD 553
Score = 63.5 bits (153), Expect = 4e-10
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 11/195 (5%)
Query: 315 YAVGGFDGSTGLSSVEAYNIKSNEWFHV-APMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 373
Y + F GS S +N K W + P RR + V ++Y +GG +
Sbjct: 271 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 325
Query: 374 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRKSVEVYDPTT 432
+ ++CYN + W T R +Y GG + G E YD T
Sbjct: 326 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 385
Query: 433 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPTTDKWTVVSSC 488
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT +
Sbjct: 386 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 445
Query: 489 MSTGRSYAGVTVIDK 503
+ +++ V V DK
Sbjct: 446 IEARKNHGLVFVKDK 460
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 260 bits (665), Expect = 2e-69
Identities = 159/494 (32%), Positives = 255/494 (51%), Gaps = 16/494 (3%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
M ES V I ++ ++L+D++YT + + NVQ L+ AA +LQL +V CCEF
Sbjct: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L+ Q+ P+NC+GI F++ AC DLL + Y HF +V EEFL L +Q+ ++ S
Sbjct: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
++L+I E +VF A + W+ D R++ + +++ +R PLLP + L++ +E +
Sbjct: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA---------PKA 231
A + L E + P E + +++R K + VGG +A
Sbjct: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
Query: 232 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQ 291
+ VE +D + W V+ L R G+ + G+V+A+GG S+ + YDPV Q
Sbjct: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
Query: 292 WTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSS 351
WT+VA+M R LG V G +YA+GG+ G+ +++E ++ N+W V M R
Sbjct: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429
Query: 352 VGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLY 411
G + GL+Y +GG + L + E Y+ + W+ + M TRR+ GV LN+ +Y
Sbjct: 430 FGCCEMQGLIYVIGGISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIY 488
Query: 412 AVGG-HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLA 470
+VGG ++ +VE Y W +VA M + R V AVNGLLYV GG +
Sbjct: 489 SVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG-----RSS 543
Query: 471 SVEYYNPTTDKWTV 484
S ++ P T ++ V
Sbjct: 544 SHDFLAPDTHRYEV 557
Score = 95.9 bits (237), Expect = 8e-20
Identities = 53/143 (37%), Positives = 76/143 (53%), Gaps = 7/143 (4%)
Query: 361 LYAVGGYDG------ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVG 414
LYAVGGY + + LS VE ++ + WT ++ + RSG GV VL ++YA+G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 415 GHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEY 474
G ++ E YDP T W VA MN R GVC G +Y +GG G+ ++E
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
Query: 475 YNPTTDKWTVVSSCMSTGRSYAG 497
++P +KW VV + M+ R Y G
Sbjct: 410 FDPDENKWEVVGN-MAVSRYYFG 431
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 247 bits (631), Expect = 2e-65
Identities = 147/476 (30%), Positives = 240/476 (50%), Gaps = 16/476 (3%)
Query: 19 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 78
L +L+++VYT + + N + LL AA Q K C FLE QL NCLG+ A A+
Sbjct: 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAE 444
Query: 79 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 138
C++L + A +A Q F +V EE L++ + + +S+D L +EE V+E VI W
Sbjct: 445 AMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKW 504
Query: 139 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPT 198
+ D R ++ A L+ VRLP + YL+ V+ E L+K+S AC+D + EA +YH+LP
Sbjct: 505 IKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLP- 563
Query: 199 EQRILMKSVRTRLRTPMNLPKLMVVVGGQ-----APKAIRSVECYDFKEERWHQVAELPS 253
R M++ RTR R + +++V+VGG+ +++ +V C++ + +W+ +A LP
Sbjct: 564 HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPF 623
Query: 254 RRCRAGMVYMAG-LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNG 312
V AG ++ GG + + V Y + D W V+ M R + V +G
Sbjct: 624 YDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDG 683
Query: 313 LLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASR 372
+Y +GG + + VE Y+ +N+W VAP+ S V GG +Y GG + A R
Sbjct: 684 KIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGR 743
Query: 373 QCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTT 432
++ Y TN W++I A LN ++ +GG ++ +YDP
Sbjct: 744 -AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----AYARATTIYDPEK 798
Query: 433 NAWRQVADMNMCRRNAGVCAVNGLLYVVGG---DDGSCNLASVEYYNPTTDKWTVV 485
+ +MN R+ ++G +Y GG +G L ++E Y PTT+ WT++
Sbjct: 799 GNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPA-LGNMEAYEPTTNTWTLL 853
Score = 50.1 bits (118), Expect = 5e-06
Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 10/148 (6%)
Query: 344 PMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCLSTVECYNATTNEWTYIAEMSTR-RSG 400
P R S GV V + VGG G +++ L V C+N N+W +A + R
Sbjct: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
Query: 401 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM--CRRNAGVCAVNGLLY 458
V + +Y GG + + V Y + W V+ M + CR N+ V +G +Y
Sbjct: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
Query: 459 VVGGDDGSCNLASVEYYNPTTDKWTVVS 486
+GG + N+ VE Y+ T++W V+
Sbjct: 687 TLGGLGVAGNVDHVERYDTITNQWEAVA 714
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 247 bits (631), Expect = 2e-65
Identities = 147/476 (30%), Positives = 240/476 (50%), Gaps = 16/476 (3%)
Query: 19 LRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFAD 78
L +L+++VYT + + N + LL AA Q K C FLE QL NCLG+ A A+
Sbjct: 385 LELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLGVLAMAE 444
Query: 79 MHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW 138
C++L + A +A Q F +V EE L++ + + +S+D L +EE V+E VI W
Sbjct: 445 AMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVYETVIKW 504
Query: 139 VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPT 198
+ D R ++ A L+ VRLP + YL+ V+ E L+K+S AC+D + EA +YH+LP
Sbjct: 505 IKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKRYHMLP- 563
Query: 199 EQRILMKSVRTRLRTPMNLPKLMVVVGGQ-----APKAIRSVECYDFKEERWHQVAELPS 253
R M++ RTR R + +++V+VGG+ +++ +V C++ + +W+ +A LP
Sbjct: 564 HARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPF 623
Query: 254 RRCRAGMVYMAG-LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNG 312
V AG ++ GG + + V Y + D W V+ M R + V +G
Sbjct: 624 YDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDG 683
Query: 313 LLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASR 372
+Y +GG + + VE Y+ +N+W VAP+ S V GG +Y GG + A R
Sbjct: 684 KIYTLGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGR 743
Query: 373 QCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTT 432
++ Y TN W++I A LN ++ +GG ++ +YDP
Sbjct: 744 -AAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGG----AYARATTIYDPEK 798
Query: 433 NAWRQVADMNMCRRNAGVCAVNGLLYVVGG---DDGSCNLASVEYYNPTTDKWTVV 485
+ +MN R+ ++G +Y GG +G L ++E Y PTT+ WT++
Sbjct: 799 GNIKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEGPA-LGNMEAYEPTTNTWTLL 853
Score = 50.1 bits (118), Expect = 5e-06
Identities = 42/148 (28%), Positives = 67/148 (45%), Gaps = 10/148 (6%)
Query: 344 PMNTRRSSVGVGVVGGLLYAVGGYD--GASRQCLSTVECYNATTNEWTYIAEMSTR-RSG 400
P R S GV V + VGG G +++ L V C+N N+W +A + R
Sbjct: 572 PRTRPRLSAGVAEV---IVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREF 628
Query: 401 AGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNM--CRRNAGVCAVNGLLY 458
V + +Y GG + + V Y + W V+ M + CR N+ V +G +Y
Sbjct: 629 FSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV--YDGKIY 686
Query: 459 VVGGDDGSCNLASVEYYNPTTDKWTVVS 486
+GG + N+ VE Y+ T++W V+
Sbjct: 687 TLGGLGVAGNVDHVERYDTITNQWEAVA 714
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 225 bits (573), Expect = 8e-59
Identities = 157/500 (31%), Positives = 234/500 (46%), Gaps = 21/500 (4%)
Query: 1 MSESRAKRVRIKE-VDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCE 59
+ ESR V ++ + L +L+D+ Y++ I + EEN + LL A +LQ DV+ E
Sbjct: 79 LRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAE 138
Query: 60 FLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLIS 119
FLE L P NCLG+ +D H C L + HF V SE+F +L + + LIS
Sbjct: 139 FLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLIS 198
Query: 120 SDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKN 179
SD+L E VFEA++ WV HD + R+ + L+ VRL LLP + L + V EAL+
Sbjct: 199 SDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMA 258
Query: 180 SSACKDYLIEAMKYHLLPTEQRILMKS--VRTRLRTPMNLPKLMVVVGGQAPKAIRSVEC 237
K + EA++ + RIL V + P ++++GGQ + +
Sbjct: 259 DERTKLIMDEALR-----CKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQ- 312
Query: 238 YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRV-RTVDSYDPVKDQWTSVA 296
D K + A+LPS R + V+ GG V + V YD V ++W+ A
Sbjct: 313 VDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAA 372
Query: 297 NMRDRRSTLGAAVLNGLLYAVGGFDG---------STGLSSVEAYNIKSNEWFHVAPMNT 347
M R G+A L LY VGG S L VE Y+ +N+W VAP+
Sbjct: 373 PMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRD 432
Query: 348 RRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLN 407
S+ V L+ GG R +S V+CY+ + N WT AE VL
Sbjct: 433 GVSNAAVVSAKLKLFVFGG-TSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLG 491
Query: 408 NLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSC 467
+ ++ +GG D S +D TN W ++ DM R + A LYVVGG G+
Sbjct: 492 SQIFIMGG-DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQ 550
Query: 468 NLASVEYYNPTTDKWTVVSS 487
+++ Y+PT+D W +++
Sbjct: 551 RCKTLDCYDPTSDTWNCITT 570
Score = 75.5 bits (184), Expect = 1e-13
Identities = 54/176 (30%), Positives = 75/176 (42%), Gaps = 11/176 (6%)
Query: 335 KSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 394
K+ E A + + R +G +Y GG G+ V Y+ EW+ A M
Sbjct: 316 KAKEIIPKADLPSPRKEFSASAIGCKVYVTGGR-GSENGVSKDVWVYDTVHEEWSKAAPM 374
Query: 395 STRRSGAGVGVLNNLLYAVGGHDG--------PLVR-KSVEVYDPTTNAWRQVADMNMCR 445
R G G L N LY VGGH P V K VE YDP N W VA +
Sbjct: 375 LIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGV 434
Query: 446 RNAGVCAVNGLLYVVGGDDGSCNLAS-VEYYNPTTDKWTVVSSCMSTGRSYAGVTV 500
NA V + L+V GG ++ S V+ Y+P+ ++WT+ + C R A +
Sbjct: 435 SNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVL 490
Score = 48.1 bits (113), Expect = 2e-05
Identities = 18/76 (23%), Positives = 38/76 (50%)
Query: 223 VVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTV 282
++GG S +D + +W ++ ++ ++R + ++ VGG+ G+ R +T+
Sbjct: 496 IMGGDTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTL 555
Query: 283 DSYDPVKDQWTSVANM 298
D YDP D W + +
Sbjct: 556 DCYDPTSDTWNCITTV 571
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 221 bits (564), Expect = 9e-58
Identities = 145/500 (29%), Positives = 254/500 (50%), Gaps = 28/500 (5%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
M E +++ V LR +ID++YTA++ + +N+Q L AA LQ+ V C F
Sbjct: 127 MKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 186
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L S + NC+ + A+ + T++ N++ ++F ++ + EFL L E++ ++SS
Sbjct: 187 LISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSS 246
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
+ L +E ++F+A W+ + + R +F A+LM+++R PL+ + L+ V+ ++
Sbjct: 247 NSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTD 305
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG---QAPKAIRSVEC 237
+ C + L+EA Y ++P Q + M+S RT +R+ +V +GG Q + +
Sbjct: 306 NTCVNLLLEASNYQMMPYMQPV-MQSDRTAIRSDTT---HLVTLGGVLRQQLVVSKELRM 361
Query: 238 YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGG-----FNGSLRVRTVDSYDPVKDQW 292
YD K W +A + + R + G+ + ++ VGG G V TV +DP ++W
Sbjct: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Query: 293 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 352
VA++ ++R+ + L G LYAVGG + + L +VE YN ++NEW +VA M+
Sbjct: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
Query: 353 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYA 412
V GG++Y GG + Q + C++ T++W A M+T R + + LY
Sbjct: 482 AGTVYGGVMYISGGITHDTFQ--KELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYV 539
Query: 413 VGG--------HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD- 463
+GG +D L S E Y P + W +A M + + GV +YVVGG
Sbjct: 540 IGGNHFRGTSDYDDVL---SCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYS 596
Query: 464 -DGSCNLASVEYYNPTTDKW 482
+ C + V+ Y+P D+W
Sbjct: 597 WNNRCMVEIVQKYDPDKDEW 616
Score = 38.1 bits (87), Expect = 0.019
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 232 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 289
+ S E Y ++W +A + + G+ ++ VGG+ N V V YDP K
Sbjct: 554 VLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDK 613
Query: 290 DQWTSVANMRDRRSTLGAAVL 310
D+W V ++ + + A L
Sbjct: 614 DEWHKVFDLPESLGGIRACTL 634
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 221 bits (563), Expect = 1e-57
Identities = 143/500 (28%), Positives = 258/500 (51%), Gaps = 28/500 (5%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
M E +++ V+ L+ +ID++YTA++ + +N+Q L AA LQ+ V C F
Sbjct: 85 MKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVF 144
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L S + NC+ + A+ + ++ N + ++F ++ + EFL L E++ ++SS
Sbjct: 145 LISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFERLAFVLSS 204
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
+ L +E ++F+A W+ + D R ++ A+LM+++R PL+ + L+ V+ ++
Sbjct: 205 NSLKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQDLINYVQTVDFMRTD 263
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAI---RSVEC 237
+ C + L+EA Y ++P Q + M+S RT +R+ +V +GG + + + +
Sbjct: 264 NTCVNLLLEASNYQMMPYMQPV-MQSDRTAIRSDSTH---LVTLGGVLRQQLVVSKELRM 319
Query: 238 YDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN-----GSLRVRTVDSYDPVKDQW 292
YD + + W +A + + R + G+ + ++ VGG + G V TV +DP ++W
Sbjct: 320 YDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 379
Query: 293 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 352
VA++ ++R+ + L G LYAVGG + L++VE YN + NEW +VA M+
Sbjct: 380 MQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGH 439
Query: 353 GVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYA 412
V GGL+Y GG + Q + + C++ T++W A M+T R + + + LY
Sbjct: 440 AGTVYGGLMYISGGITHDTFQ--NELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYV 497
Query: 413 VGG--------HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGD- 463
+GG +D L S E Y PT + W +A M + + GV +YVVGG
Sbjct: 498 IGGNHFRGTSDYDDVL---SCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYS 554
Query: 464 -DGSCNLASVEYYNPTTDKW 482
+ C + V+ Y+P D+W
Sbjct: 555 WNNRCMVEIVQKYDPEKDEW 574
Score = 44.7 bits (104), Expect = 2e-04
Identities = 23/73 (31%), Positives = 36/73 (49%), Gaps = 5/73 (6%)
Query: 420 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDD-----GSCNLASVEY 474
+V K + +YD WR +A M+ R G+ + LYVVGG G + +V
Sbjct: 312 VVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFR 371
Query: 475 YNPTTDKWTVVSS 487
++P +KW V+S
Sbjct: 372 FDPRYNKWMQVAS 384
Score = 39.3 bits (90), Expect = 0.008
Identities = 21/81 (25%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 232 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGF--NGSLRVRTVDSYDPVK 289
+ S E Y ++W +A + + G+ ++ VGG+ N V V YDP K
Sbjct: 512 VLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEK 571
Query: 290 DQWTSVANMRDRRSTLGAAVL 310
D+W V ++ + + A L
Sbjct: 572 DEWHKVFDLPESLGGIRACTL 592
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 219 bits (559), Expect = 4e-57
Identities = 151/516 (29%), Positives = 243/516 (47%), Gaps = 27/516 (5%)
Query: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
+ E KR+ IK VD T+ L+DY YT++ +T++NVQ +L AA L Q + C F
Sbjct: 105 LKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASF 164
Query: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
L L+P NC+GI AD H+ L + +Y Q+F ++ SEEFL+L ++ + ++ S
Sbjct: 165 LTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKS 224
Query: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
D L ++ E +VFE V++WV H R + ++E+VRLPLL Y V+ VE + L++
Sbjct: 225 DDLYVTEEAQVFETVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQC 284
Query: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGG--QAPKAIRSVECY 238
L EA YHL E + S RT+ R ++ +++GG + + + V C
Sbjct: 285 PEVFPLLQEARMYHLSGNE----IISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCL 340
Query: 239 DFKEERWHQVAELP----------SRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPV 288
D +VA+LP + V + V+ GG V Y+
Sbjct: 341 DPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQ---HDVWKYNSS 397
Query: 289 KDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTR 348
++W + + R VL G +Y +GGFDG +++VE Y+ N W AP+
Sbjct: 398 INKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVH 457
Query: 349 RSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNN 408
SS LY +GG + +CY+ +TN+W+ A M +
Sbjct: 458 VSSFAATSHKKKLYVIGGGPN-GKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRD 516
Query: 409 LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSC 467
+Y VGG +++ Y P ++W V ++ R + G+ N LY+ GG D+ +
Sbjct: 517 RIYVVGG-----AMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKNE 571
Query: 468 NLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDK 503
+A+V ++P K T + G S+ G I K
Sbjct: 572 VIATVLCWDPEAQKLT-EECVLPRGVSHHGSVTIRK 606
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,742,646
Number of Sequences: 37866
Number of extensions: 748087
Number of successful extensions: 2956
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 117
Number of HSP's successfully gapped in prelim test: 35
Number of HSP's that attempted gapping in prelim test: 1601
Number of HSP's gapped (non-prelim): 345
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.