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Search of human proteins with 116235462
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|116235462 solute carrier family 25, member 45 isoform a
[Homo sapiens]
(288 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 590 e-169
gi|116235466 solute carrier family 25, member 45 isoform b [Homo... 504 e-143
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 250 9e-67
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 209 3e-54
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 161 5e-40
gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens] 133 2e-31
gi|13994341 solute carrier family 25 member 2 [Homo sapiens] 130 2e-30
gi|223468576 mitochondrial carrier protein-like [Homo sapiens] 129 2e-30
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 126 3e-29
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 126 3e-29
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 126 3e-29
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 107 9e-24
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 105 4e-23
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 101 7e-22
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 99 3e-21
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 99 6e-21
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 99 6e-21
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 99 6e-21
gi|13899342 solute carrier [Homo sapiens] 98 1e-20
gi|21314739 solute carrier family 25, member 32 [Homo sapiens] 96 5e-20
gi|149274643 solute carrier family 25, member 28 [Homo sapiens] 89 6e-18
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 87 1e-17
gi|27544933 solute carrier family 25, member 16 [Homo sapiens] 87 1e-17
gi|82775373 solute carrier family 25, member 37 [Homo sapiens] 87 2e-17
gi|13259541 uncoupling protein 2 [Homo sapiens] 87 2e-17
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 86 3e-17
gi|157388991 solute carrier family 25, member 36 isoform b [Homo... 86 4e-17
gi|157388989 solute carrier family 25, member 36 isoform a [Homo... 86 4e-17
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 84 1e-16
gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Ho... 83 2e-16
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 590 bits (1521), Expect = e-169
Identities = 288/288 (100%), Positives = 288/288 (100%)
Query: 1 MPVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTTYRGIVDCMVKIYRHESLLGFFKGMS 60
MPVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTTYRGIVDCMVKIYRHESLLGFFKGMS
Sbjct: 1 MPVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTTYRGIVDCMVKIYRHESLLGFFKGMS 60
Query: 61 FPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPF 120
FPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPF
Sbjct: 61 FPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPF 120
Query: 121 DLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGI 180
DLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGI
Sbjct: 121 DLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGI 180
Query: 181 YFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQ 240
YFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQ
Sbjct: 181 YFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQ 240
Query: 241 GMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWWG 288
GMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWWG
Sbjct: 241 GMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWWG 288
>gi|116235466 solute carrier family 25, member 45 isoform b [Homo
sapiens]
Length = 246
Score = 504 bits (1298), Expect = e-143
Identities = 246/246 (100%), Positives = 246/246 (100%)
Query: 43 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI 102
MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI
Sbjct: 1 MVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHI 60
Query: 103 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 162
FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG
Sbjct: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
Query: 163 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 222
LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL
Sbjct: 121 LFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPL 180
Query: 223 DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY
Sbjct: 181 DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 240
Query: 283 LLRWWG 288
LLRWWG
Sbjct: 241 LLRWWG 246
Score = 73.9 bits (180), Expect = 1e-13
Identities = 61/196 (31%), Positives = 82/196 (41%), Gaps = 24/196 (12%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQT-----------TYRGIVDCMVKIYRHESLLG 54
F+AG G L PFD +KVRLQ QT Y+G V C I+R E G
Sbjct: 61 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 120
Query: 55 FFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQA 114
F+G ++ + ++ G+Y T L E Q PS + +AG G
Sbjct: 121 LFRG----AWALTLRDTPTVGIYFITYEGLCRQYTPE--GQNPSSATVLVAGGFAGIASW 174
Query: 115 YCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRD 174
P D+IK R+Q G YQG + C S R+EG FRG + R
Sbjct: 175 VAATPLDMIKSRMQ-------MDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARA 227
Query: 175 TPTVGIYFITYEGLCR 190
P + F++YE L R
Sbjct: 228 FPVNAVTFLSYEYLLR 243
>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
Length = 308
Score = 250 bits (639), Expect = 9e-67
Identities = 127/301 (42%), Positives = 187/301 (62%), Gaps = 21/301 (6%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQTTYRGIVDCMVKIYRHESLLGFFKGMSFPIA 64
+FVAG I G G+ +G+P DTVKVR+QT+ Y GI C+ Y E + GF++G+S P+
Sbjct: 2 DFVAGAIGGVCGVAVGYPLDTVKVRIQTEPKYTGIWHCVRDTYHRERVWGFYRGLSLPVC 61
Query: 65 SIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIK 124
++++V+SV FG Y + L + + A+P I L+GC G ++ + +P ++ K
Sbjct: 62 TVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTK-ADITLSGCASGLVRVFLTSPTEVAK 120
Query: 125 VRLQNQTEPRAQ-------------------PGSPPPRYQGPVHCAASIFREEGPRGLFR 165
VRLQ QT+ + Q P P P+Y+GP+HC A++ REEG GL++
Sbjct: 121 VRLQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLCGLYK 180
Query: 166 GAWALTLRDTPTVGIYFITYEGLCRQYTPEGQN-PSSATVLVAGGFAGIASWVAATPLDM 224
G+ AL LRD + YF++Y LC +P G + P VLVAGG AG+ +W ATP+D+
Sbjct: 181 GSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVLVAGGCAGVLAWAVATPMDV 240
Query: 225 IKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLL 284
IKSR+Q DG +R Y+G+L CMV+S+R+EG V F+G+ +N RAFPVN V F++YE +L
Sbjct: 241 IKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVAYEAVL 300
Query: 285 R 285
R
Sbjct: 301 R 301
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 209 bits (531), Expect = 3e-54
Identities = 119/288 (41%), Positives = 166/288 (57%), Gaps = 22/288 (7%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQTT----YRGIVDCMVKIYRHESLLGFFKGMS 60
+F+AG G G+++GHPFDTVKVRLQ Q+ YRG + C I + ES+LG +KG+
Sbjct: 4 DFLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKGLG 63
Query: 61 FPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPF 120
P+ + +N+++FGV NTL L H S ++ FLAG G +Q P
Sbjct: 64 SPLMGLTFINALVFGVQGNTLRAL---GHD-------SPLNQFLAGAAAGAIQCVICCPM 113
Query: 121 DLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGI 180
+L K RLQ Q P Y+G + C A I+ EG RG+ RG + LR+TP+ G+
Sbjct: 114 ELAKTRLQ------LQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGV 167
Query: 181 YFITYEGLCRQYTPE-GQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRV- 238
YF+TY+ L R E G +L+AGG +GI SW++ P+D++KSR+Q DGLR
Sbjct: 168 YFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPR 227
Query: 239 YQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRW 286
Y+G+LDC+ S R EG VF RG+ RAFPVNA TF + +L +
Sbjct: 228 YRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFATVTVVLTY 275
Score = 89.7 bits (221), Expect = 3e-18
Identities = 63/189 (33%), Positives = 90/189 (47%), Gaps = 16/189 (8%)
Query: 103 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 162
FLAGC GG PFD +KVRLQ Q+ + P+Y+G +HC SI ++E G
Sbjct: 5 FLAGCAGGVAGVLVGHPFDTVKVRLQVQSVEK-------PQYRGTLHCFKSIIKQESVLG 57
Query: 163 LFRGAWALTLRDTPTVGIYFIT--YEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAAT 220
L++G +P +G+ FI G+ + S +AG AG V
Sbjct: 58 LYKGL------GSPLMGLTFINALVFGVQGNTLRALGHDSPLNQFLAGAAAGAIQCVICC 111
Query: 221 PLDMIKSRMQM-DGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLS 279
P+++ K+R+Q+ D R Y+G LDC+ EGL RG+ R P V FL+
Sbjct: 112 PMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLT 171
Query: 280 YEYLLRWWG 288
Y+ L R G
Sbjct: 172 YDALTRALG 180
Score = 81.3 bits (199), Expect = 9e-16
Identities = 69/213 (32%), Positives = 92/213 (43%), Gaps = 20/213 (9%)
Query: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQT-----TYRGIVDCMVKIYRHESLLGFF 56
P+ +F+AG +GA+ V+ P + K RLQ Q TY+G +DC+ +IY HE L G
Sbjct: 92 PLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVN 151
Query: 57 KGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQER--RAQPPSYMHIFLAGCTGGFLQA 114
+GM S + + FGVY T LT E R P + LAG T G +
Sbjct: 152 RGM----VSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPK---LLLAGGTSGIVSW 204
Query: 115 YCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRD 174
P D++K RLQ A PRY+G + C +R EG R RG + LR
Sbjct: 205 LSTYPVDVVKSRLQ------ADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRA 258
Query: 175 TPTVGIYFITYEGLCRQYTPEGQNPSSATVLVA 207
P F T + E P V A
Sbjct: 259 FPVNAATFATVTVVLTYARGEEAGPEGEAVPAA 291
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 161 bits (408), Expect = 5e-40
Identities = 101/296 (34%), Positives = 145/296 (48%), Gaps = 23/296 (7%)
Query: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTT--------YRGIVDCMVKIYRHESLL 53
P++ +AG G + +GHP DTVKVRLQTQ Y G DC K E +
Sbjct: 10 PLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGIT 69
Query: 54 GFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQ 113
G ++GM+ PI + + +V F + L Q+ SY +F AG G
Sbjct: 70 GLYRGMAAPIIGVTPMFAVCFFGFG-----LGKKLQQKHPEDVLSYPQLFAAGMLSGVFT 124
Query: 114 AYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLR 173
+ P + IK LQ Q S +Y G + CA +++E G RG+++G +R
Sbjct: 125 TGIMTPGERIKCLLQ------IQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMR 178
Query: 174 DTPTVGIYFITYEGLCRQYTPEGQNPSSAT---VLVAGGFAGIASWVAATPLDMIKSRMQ 230
D P G+YF+TYE L +TPEG+ S + +LVAGG AGI +W A P D++KSR Q
Sbjct: 179 DVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAVAIPPDVLKSRFQ 238
Query: 231 MDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRW 286
+ G D + IR EG+ ++G RAFP NA FL +E +++
Sbjct: 239 -TAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKF 293
Score = 77.0 bits (188), Expect = 2e-14
Identities = 60/193 (31%), Positives = 89/193 (46%), Gaps = 9/193 (4%)
Query: 95 QPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASI 154
+P S + LAG GG + P D +KVRL QT+P + PG PP Y G C
Sbjct: 6 KPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRL--QTQPPSLPGQ-PPMYSGTFDCFRKT 62
Query: 155 FREEGPRGLFRGAWALTLRDTPTVGIYFITYEGL---CRQYTPEGQNPSSATVLVAGGFA 211
EG GL+RG A + TP + F + GL +Q PE S + AG +
Sbjct: 63 LFREGITGLYRGMAAPIIGVTPMFAVCFFGF-GLGKKLQQKHPE-DVLSYPQLFAAGMLS 120
Query: 212 GIASWVAATPLDMIKSRMQMDGLR-RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAF 270
G+ + TP + IK +Q+ Y G LDC ++ G+ ++G + R
Sbjct: 121 GVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDV 180
Query: 271 PVNAVTFLSYEYL 283
P + + F++YE+L
Sbjct: 181 PASGMYFMTYEWL 193
>gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]
Length = 301
Score = 133 bits (335), Expect = 2e-31
Identities = 88/282 (31%), Positives = 136/282 (48%), Gaps = 8/282 (2%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQT-QTTYRGIVDCMVKIYRHESLLGFFKGMSFPI 63
+ AG G ++ G PFDT+KV++QT YRG+ DC +K Y GF+KG S +
Sbjct: 12 DLTAGAAGGTACVLTGQPFDTMKVKMQTFPDLYRGLTDCCLKTYSQVGFRGFYKGTSPAL 71
Query: 64 ASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLI 123
+ NSVLF Y V+ + +++A+ S + AG A L P +L+
Sbjct: 72 IANIAENSVLFMCYGFCQQVVRKVAGLDKQAK-LSDLQNAAAGSFASAFAALVLCPTELV 130
Query: 124 KVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFI 183
K RLQ E G SI R++GP G + G + LR+ P +F
Sbjct: 131 KCRLQTMYEMETS-GKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGYFFFFG 189
Query: 184 TYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQ 240
YE L R + G++ ++++GG GI W+A P+D IKSR+Q+ + +
Sbjct: 190 GYE-LSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGK-QA 247
Query: 241 GMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
G + ++ ++ EG+ + G+ RAFP N FL+YEY
Sbjct: 248 GFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEY 289
Score = 38.5 bits (88), Expect = 0.007
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 5/87 (5%)
Query: 198 NPS--SATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGL 255
NP+ +A L AG G A + P D +K +MQ +Y+G+ DC + + Q G
Sbjct: 4 NPAIQAAIDLTAGAAGGTACVLTGQPFDTMKVKMQ---TFPDLYRGLTDCCLKTYSQVGF 60
Query: 256 GVFFRGVTINSARAFPVNAVTFLSYEY 282
F++G + N+V F+ Y +
Sbjct: 61 RGFYKGTSPALIANIAENSVLFMCYGF 87
Score = 28.9 bits (63), Expect = 5.5
Identities = 16/79 (20%), Positives = 33/79 (41%), Gaps = 3/79 (3%)
Query: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQT---TYRGIVDCMVKIYRHESLLGFFKG 58
PV ++G + G + +P D +K R+Q + G + + + ++E + + G
Sbjct: 209 PVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSGKQAGFIRTFINVVKNEGITALYSG 268
Query: 59 MSFPIASIAVVNSVLFGVY 77
+ + N LF Y
Sbjct: 269 LKPTMIRAFPANGALFLAY 287
>gi|13994341 solute carrier family 25 member 2 [Homo sapiens]
Length = 301
Score = 130 bits (326), Expect = 2e-30
Identities = 83/282 (29%), Positives = 135/282 (47%), Gaps = 8/282 (2%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQT-QTTYRGIVDCMVKIYRHESLLGFFKGMSFPI 63
+ AG G ++ G PFDT+KV++QT Y+G+ DC +K Y L GF+KG +
Sbjct: 12 DLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFYKGTGPAL 71
Query: 64 ASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLI 123
+ NSVLF Y + + +++A+ S + AG A L P +L+
Sbjct: 72 MAYVAENSVLFMCYGFCQQFVRKVAGMDKQAK-LSDLQTAAAGSFASAFAALALCPTELV 130
Query: 124 KVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFI 183
K RLQ E G + I +++GP G + G + L++ P +F
Sbjct: 131 KCRLQTMYE-MEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFG 189
Query: 184 TYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQ 240
YE L R + G++ ++++GG AGI W+ P+D IKSR+Q+ + +
Sbjct: 190 GYE-LSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGK-QA 247
Query: 241 GMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
G + ++S +R EG+ + G+ RA P N F++YEY
Sbjct: 248 GFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEY 289
Score = 40.4 bits (93), Expect = 0.002
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 3/87 (3%)
Query: 196 GQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGL 255
G +A L AG G A + P D IK +MQ +Y+G+ DC + + Q GL
Sbjct: 4 GPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQ---TFPDLYKGLTDCFLKTYAQVGL 60
Query: 256 GVFFRGVTINSARAFPVNAVTFLSYEY 282
F++G N+V F+ Y +
Sbjct: 61 RGFYKGTGPALMAYVAENSVLFMCYGF 87
Score = 36.2 bits (82), Expect = 0.034
Identities = 18/79 (22%), Positives = 37/79 (46%), Gaps = 3/79 (3%)
Query: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTTY---RGIVDCMVKIYRHESLLGFFKG 58
PV ++G ++G ++ P D +K R+Q + Y G + ++ + R+E ++ + G
Sbjct: 209 PVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSG 268
Query: 59 MSFPIASIAVVNSVLFGVY 77
+ + N LF Y
Sbjct: 269 LKATMIRAIPANGALFVAY 287
>gi|223468576 mitochondrial carrier protein-like [Homo sapiens]
Length = 157
Score = 129 bits (325), Expect = 2e-30
Identities = 66/132 (50%), Positives = 84/132 (63%), Gaps = 1/132 (0%)
Query: 3 VEEFVAGWISGALGLVLGHPFDTVKVRLQTQTTYRGIVDCMVKIYRHESLLGFFKGMSFP 62
+E+F AGWI GA +++GHP DTVK RLQ Y + C+ +YR ES+ GFFKGMSFP
Sbjct: 6 LEDFAAGWIGGAASVIVGHPLDTVKTRLQAGVGYGNTLSCIRVVYRRESMFGFFKGMSFP 65
Query: 63 IASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPP-SYMHIFLAGCTGGFLQAYCLAPFD 121
+ASIAV NSV+FGV+SNT L+ E A PP + + LA G + P D
Sbjct: 66 LASIAVYNSVVFGVFSNTQRFLSQHRCGEPEASPPRTLSDLLLASMVAGVVSVGLGGPVD 125
Query: 122 LIKVRLQNQTEP 133
LIK+RLQ QT+P
Sbjct: 126 LIKIRLQMQTQP 137
Score = 42.0 bits (97), Expect = 6e-04
Identities = 38/136 (27%), Positives = 59/136 (43%), Gaps = 18/136 (13%)
Query: 103 FLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRG 162
F AG GG P D +K RLQ A G Y + C ++R E G
Sbjct: 9 FAAGWIGGAASVIVGHPLDTVKTRLQ------AGVG-----YGNTLSCIRVVYRRESMFG 57
Query: 163 LFRGAW----ALTLRDTPTVGIYFITYEGLCRQYT--PEGQNPSSAT-VLVAGGFAGIAS 215
F+G ++ + ++ G++ T L + PE P + + +L+A AG+ S
Sbjct: 58 FFKGMSFPLASIAVYNSVVFGVFSNTQRFLSQHRCGEPEASPPRTLSDLLLASMVAGVVS 117
Query: 216 WVAATPLDMIKSRMQM 231
P+D+IK R+QM
Sbjct: 118 VGLGGPVDLIKIRLQM 133
Score = 36.6 bits (83), Expect = 0.026
Identities = 24/71 (33%), Positives = 36/71 (50%), Gaps = 4/71 (5%)
Query: 207 AGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINS 266
AG G AS + PLD +K+R+Q G+ Y L C+ R+E + FF+G++
Sbjct: 11 AGWIGGAASVIVGHPLDTVKTRLQA-GVG---YGNTLSCIRVVYRRESMFGFFKGMSFPL 66
Query: 267 ARAFPVNAVTF 277
A N+V F
Sbjct: 67 ASIAVYNSVVF 77
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 126 bits (316), Expect = 3e-29
Identities = 84/292 (28%), Positives = 128/292 (43%), Gaps = 26/292 (8%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQT---------TYRGIVDCMVKIYRHESLLGFF 56
F G ++GA+G +P D VK R+Q Q Y+ DC K+ R+E G +
Sbjct: 330 FTLGSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLY 389
Query: 57 KGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYC 116
+G+ + +A ++ V R P + GC GG Q
Sbjct: 390 RGLIPQLIGVAPEKAIKLTVND-----FVRDKFTRRDGSVPLPAEVLAGGCAGGS-QVIF 443
Query: 117 LAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTP 176
P +++K+RLQ E GP A ++ R+ G GL++GA A LRD P
Sbjct: 444 TNPLEIVKIRLQVAGEITT----------GPRVSALNVLRDLGIFGLYKGAKACFLRDIP 493
Query: 177 TVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDG-LR 235
IYF Y E + +L AG AG+ + TP D+IK+R+Q+
Sbjct: 494 FSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGVPAASLVTPADVIKTRLQVAARAG 553
Query: 236 RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWW 287
+ Y G++DC +R+EG F++G R+ P VT ++YE L RW+
Sbjct: 554 QTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQRWF 605
Score = 69.7 bits (169), Expect = 3e-12
Identities = 55/204 (26%), Positives = 87/204 (42%), Gaps = 20/204 (9%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQ-TTYRGIVDCMVKIYRHESLLGFFKGMSFPI 63
E +AG +G ++ +P + VK+RLQ G + + R + G +KG
Sbjct: 429 EVLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALNVLRDLGIFGLYKGAKACF 488
Query: 64 ASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLI 123
+++ F VY++ L+L + +++ AG G A + P D+I
Sbjct: 489 LRDIPFSAIYFPVYAHCKLLLADENGH------VGGLNLLAAGAMAGVPAASLVTPADVI 542
Query: 124 KVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFI 183
K RLQ A+ G Y G + C I REEGP ++G A R +P G+ +
Sbjct: 543 KTRLQ----VAARAGQ--TTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLV 596
Query: 184 TYEGLCRQY-------TPEGQNPS 200
TYE L R + P G P+
Sbjct: 597 TYELLQRWFYIDFGGLKPAGSEPT 620
Score = 35.8 bits (81), Expect = 0.045
Identities = 33/129 (25%), Positives = 48/129 (37%), Gaps = 16/129 (12%)
Query: 163 LFRGAWALTLRDTPTV-----GIYFITYEGLCRQYTPEGQNP------SSATVLVAGGFA 211
L+ + LTL D + G L RQ +P P SA G A
Sbjct: 277 LYNASGRLTLADIERIAPLAEGALPYNLAELQRQQSPGLGRPIWLQIAESAYRFTLGSVA 336
Query: 212 GIASWVAATPLDMIKSRMQMDG-----LRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINS 266
G A P+D++K+RMQ + +Y+ DC +R EG +RG+
Sbjct: 337 GAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGLIPQL 396
Query: 267 ARAFPVNAV 275
P A+
Sbjct: 397 IGVAPEKAI 405
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 126 bits (316), Expect = 3e-29
Identities = 85/292 (29%), Positives = 132/292 (45%), Gaps = 26/292 (8%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQTT---------YRGIVDCMVKIYRHESLLGFF 56
F G ++GA+G +P D VK R+Q Q + Y+ DC K+ R+E G +
Sbjct: 332 FGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLY 391
Query: 57 KGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYC 116
+G+ + +A ++ V + P I GC GG Q
Sbjct: 392 RGLLPQLLGVAPEKAIKLTVND-----FVRDKFMHKDGSVPLAAEILAGGCAGGS-QVIF 445
Query: 117 LAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTP 176
P +++K+RLQ E GP A S+ R+ G G+++GA A LRD P
Sbjct: 446 TNPLEIVKIRLQVAGEITT----------GPRVSALSVVRDLGFFGIYKGAKACFLRDIP 495
Query: 177 TVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDG-LR 235
IYF Y + + E S ++L+AG AG+ + TP D+IK+R+Q+
Sbjct: 496 FSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAG 555
Query: 236 RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWW 287
+ Y G++DC +R+EG ++G R+ P VT L+YE L RW+
Sbjct: 556 QTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRWF 607
Score = 75.1 bits (183), Expect = 7e-14
Identities = 55/189 (29%), Positives = 88/189 (46%), Gaps = 13/189 (6%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQ-TTYRGIVDCMVKIYRHESLLGFFKGMSFPI 63
E +AG +G ++ +P + VK+RLQ G + + R G +KG
Sbjct: 431 EILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACF 490
Query: 64 ASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLI 123
+++ F Y++ V + ++++ + P S + LAG G A + P D+I
Sbjct: 491 LRDIPFSAIYFPCYAH---VKASFANEDGQVSPGS---LLLAGAIAGMPAASLVTPADVI 544
Query: 124 KVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFI 183
K RLQ A+ G Y G + C I REEGP+ L++GA A R +P G+ +
Sbjct: 545 KTRLQ----VAARAGQ--TTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLL 598
Query: 184 TYEGLCRQY 192
TYE L R +
Sbjct: 599 TYELLQRWF 607
Score = 42.7 bits (99), Expect = 4e-04
Identities = 25/62 (40%), Positives = 31/62 (50%), Gaps = 5/62 (8%)
Query: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQT-----QTTYRGIVDCMVKIYRHESLLGFF 56
P +AG I+G L P D +K RLQ QTTY G++DC KI R E +
Sbjct: 520 PGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALW 579
Query: 57 KG 58
KG
Sbjct: 580 KG 581
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 126 bits (316), Expect = 3e-29
Identities = 85/292 (29%), Positives = 132/292 (45%), Gaps = 26/292 (8%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQTT---------YRGIVDCMVKIYRHESLLGFF 56
F G ++GA+G +P D VK R+Q Q + Y+ DC K+ R+E G +
Sbjct: 333 FGLGSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLY 392
Query: 57 KGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYC 116
+G+ + +A ++ V + P I GC GG Q
Sbjct: 393 RGLLPQLLGVAPEKAIKLTVND-----FVRDKFMHKDGSVPLAAEILAGGCAGGS-QVIF 446
Query: 117 LAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTP 176
P +++K+RLQ E GP A S+ R+ G G+++GA A LRD P
Sbjct: 447 TNPLEIVKIRLQVAGEITT----------GPRVSALSVVRDLGFFGIYKGAKACFLRDIP 496
Query: 177 TVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDG-LR 235
IYF Y + + E S ++L+AG AG+ + TP D+IK+R+Q+
Sbjct: 497 FSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAG 556
Query: 236 RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWW 287
+ Y G++DC +R+EG ++G R+ P VT L+YE L RW+
Sbjct: 557 QTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRWF 608
Score = 75.1 bits (183), Expect = 7e-14
Identities = 55/189 (29%), Positives = 88/189 (46%), Gaps = 13/189 (6%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQ-TTYRGIVDCMVKIYRHESLLGFFKGMSFPI 63
E +AG +G ++ +P + VK+RLQ G + + R G +KG
Sbjct: 432 EILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACF 491
Query: 64 ASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLI 123
+++ F Y++ V + ++++ + P S + LAG G A + P D+I
Sbjct: 492 LRDIPFSAIYFPCYAH---VKASFANEDGQVSPGS---LLLAGAIAGMPAASLVTPADVI 545
Query: 124 KVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFI 183
K RLQ A+ G Y G + C I REEGP+ L++GA A R +P G+ +
Sbjct: 546 KTRLQ----VAARAGQ--TTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLL 599
Query: 184 TYEGLCRQY 192
TYE L R +
Sbjct: 600 TYELLQRWF 608
Score = 42.7 bits (99), Expect = 4e-04
Identities = 25/62 (40%), Positives = 31/62 (50%), Gaps = 5/62 (8%)
Query: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQT-----QTTYRGIVDCMVKIYRHESLLGFF 56
P +AG I+G L P D +K RLQ QTTY G++DC KI R E +
Sbjct: 521 PGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALW 580
Query: 57 KG 58
KG
Sbjct: 581 KG 582
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 107 bits (268), Expect = 9e-24
Identities = 82/293 (27%), Positives = 134/293 (45%), Gaps = 24/293 (8%)
Query: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTT-----YRGIVDCMVKIYRHESLLGFF 56
P + +AG ++G + + + P + VK +LQ YRGI DC+ + R +LG +
Sbjct: 25 PGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLY 84
Query: 57 KGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYC 116
+G+S + +V FG++ ++H L G G +A
Sbjct: 85 RGLSSLLYGSIPKAAVRFGMFE------FLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVV 138
Query: 117 LA-PFDLIKVR-LQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRD 174
+ P + IKV+ + +QT SP P+Y+G H I RE+G +G ++G A L+
Sbjct: 139 VVCPMETIKVKFIHDQT-------SPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQ 191
Query: 175 TPTVGIYFITYEGLCRQYTPEGQNPSSATVL--VAGGFAGIASWVAATPLDMIKSRMQMD 232
I F L Y + N ++ V G AG AS TPLD+IK+RMQ
Sbjct: 192 GSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQ-- 249
Query: 233 GLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLR 285
GL Y+ DC + +++EGL F++G R A+ F+ Y+ +++
Sbjct: 250 GLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVK 302
Score = 57.4 bits (137), Expect = 1e-08
Identities = 48/186 (25%), Positives = 75/186 (40%), Gaps = 8/186 (4%)
Query: 104 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 163
LAG G ++ P + +K +LQ S PPRY+G C R G GL
Sbjct: 30 LAGGLAGGIEICITFPTEYVKTQLQLDER------SHPPRYRGIGDCVRQTVRSHGVLGL 83
Query: 164 FRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIA-SWVAATPL 222
+RG +L P + F +E L S L+ G AG+A + V P+
Sbjct: 84 YRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPM 143
Query: 223 DMIKSRMQMDGLR-RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 281
+ IK + D Y+G + +R++GL ++G+T + A+ F
Sbjct: 144 ETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMT 203
Query: 282 YLLRWW 287
L W+
Sbjct: 204 SLRNWY 209
Score = 40.8 bits (94), Expect = 0.001
Identities = 24/85 (28%), Positives = 42/85 (49%), Gaps = 2/85 (2%)
Query: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTT--YRGIVDCMVKIYRHESLLGFFKGM 59
P+ V G I+GA + P D +K R+Q YR DC ++I + E L F+KG
Sbjct: 220 PLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGT 279
Query: 60 SFPIASIAVVNSVLFGVYSNTLLVL 84
+ + + +++F +Y + +L
Sbjct: 280 VPRLGRVCLDVAIVFVIYDEVVKLL 304
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 105 bits (263), Expect = 4e-23
Identities = 85/306 (27%), Positives = 127/306 (41%), Gaps = 40/306 (13%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQTT----YRGIVDCMVKIYRHESLLGFFKGMS 60
+ + G I+G +G+ P D K RLQ Q Y + DC++K R E G ++G
Sbjct: 11 KLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRG-- 68
Query: 61 FPIASIAVVNSVLFGVYSNTLLVLTATS---HQ-ERRAQPPSYMHIFLAGCTGGFLQAYC 116
A VN L V + L A HQ + Q + + LAGC G Q
Sbjct: 69 ------AAVNLTL--VTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQVIV 120
Query: 117 LAPFDLIKVRLQNQTEPRAQ------------PGSPPPRYQGPV-------HCAASIFRE 157
P +++K++LQ+ AQ G P + P + R
Sbjct: 121 TTPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQLTRDLLRS 180
Query: 158 EGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATV-LVAGGFAGIASW 216
G GL++G A LRD P +YF + L + P + S V +AG AG A+
Sbjct: 181 RGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEKSPFYVSFLAGCVAGSAAA 240
Query: 217 VAATPLDMIKSRMQ--MDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNA 274
VA P D++K+R+Q G+ Y G+LDC +R EG F +G + P+
Sbjct: 241 VAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIAPLFG 300
Query: 275 VTFLSY 280
+ + Y
Sbjct: 301 IAQVVY 306
Score = 55.1 bits (131), Expect = 7e-08
Identities = 24/78 (30%), Positives = 41/78 (52%)
Query: 205 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTI 264
L+ GG AG+ P+D+ K+R+Q +RVY M DC++ ++R EG +RG +
Sbjct: 12 LINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRGAAV 71
Query: 265 NSARAFPVNAVTFLSYEY 282
N P A+ + ++
Sbjct: 72 NLTLVTPEKAIKLAANDF 89
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 101 bits (252), Expect = 7e-22
Identities = 88/295 (29%), Positives = 133/295 (45%), Gaps = 30/295 (10%)
Query: 3 VEEFVAGWISGALGLVLGHPFDTVKVRLQTQ------TTYRGIVDCMVKIYRHESLLGFF 56
++ F+ G ISG +L P D +K RLQT + G++ ++K+ R ESLLG +
Sbjct: 28 IKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTESLLGLW 87
Query: 57 KGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYC 116
KGMS I + V V G+Y TL L R PP+ + + G + C
Sbjct: 88 KGMSPSI--VRCVPGV--GIYFGTLYSL---KQYFLRGHPPTALESVMLGVGSRSVAGVC 140
Query: 117 LAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTP 176
++P +IK R + S Y+ SI+ EG RGLF G A LRD P
Sbjct: 141 MSPITVIKTRYE----------SGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAP 190
Query: 177 TVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVAATPLDMIKSRMQMDG 233
GIY + Y + P Q ++ T G FAGI + + P D+IK+ MQ+
Sbjct: 191 FSGIYLMFY-NQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQLYP 249
Query: 234 LRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWWG 288
L+ +Q + + + GL FF+G + R + A+ + YE ++ G
Sbjct: 250 LK---FQWIGQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMMAKMG 301
Score = 31.6 bits (70), Expect = 0.84
Identities = 16/59 (27%), Positives = 29/59 (49%), Gaps = 1/59 (1%)
Query: 1 MPVEEFVAGWISGALGLVLGHPFDTVKVRLQT-QTTYRGIVDCMVKIYRHESLLGFFKG 58
+P+ F G +G L ++ P D +K +Q ++ I + I++ L GFF+G
Sbjct: 216 IPITNFSCGIFAGILASLVTQPADVIKTHMQLYPLKFQWIGQAVTLIFKDYGLRGFFQG 274
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 99.4 bits (246), Expect = 3e-21
Identities = 80/293 (27%), Positives = 125/293 (42%), Gaps = 21/293 (7%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQ-----------TTYRGIVDCMVKIYRHESLL 53
+F+ + ++ P DT KVRLQ Q YRG++ ++ + R E
Sbjct: 16 KFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPC 75
Query: 54 GFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQ 113
+ G+ + S+ G+Y + V T + A S LAGCT G +
Sbjct: 76 SPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTP-----KGADNSSLTTRILAGCTTGAMA 130
Query: 114 AYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLR 173
C P D++KVR Q P +Y G + +I REEG RGL++G +R
Sbjct: 131 VTCAQPTDVVKVRFQASIH--LGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMR 188
Query: 174 DTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGF-AGIASWVAATPLDMIKSRMQMD 232
+ +TY+ L + + F AG + V A+P+D++K+R
Sbjct: 189 NAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNS 248
Query: 233 GLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLR 285
+ Y LDCM+ + QEG F++G T + R N V F++YE L R
Sbjct: 249 PPGQ--YFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKR 299
Score = 72.4 bits (176), Expect = 4e-13
Identities = 58/194 (29%), Positives = 86/194 (44%), Gaps = 6/194 (3%)
Query: 96 PPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIF 155
PP+ FL T P D KVRLQ Q E +A + +Y+G + ++
Sbjct: 10 PPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMV 69
Query: 156 REEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATV-LVAGGFAGIA 214
R EGP + G A R I Y+ + + YTP+G + SS T ++AG G
Sbjct: 70 RTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAM 129
Query: 215 SWVAATPLDMIKSRMQMD---GLRR--RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARA 269
+ A P D++K R Q G R R Y G +D + R+EG+ ++G N R
Sbjct: 130 AVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRN 189
Query: 270 FPVNAVTFLSYEYL 283
VN ++Y+ L
Sbjct: 190 AIVNCAEVVTYDIL 203
Score = 31.6 bits (70), Expect = 0.84
Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 7/68 (10%)
Query: 194 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRV-------YQGMLDCM 246
P P+ A + G A + + PLD K R+Q+ G + V Y+G+L +
Sbjct: 6 PSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTI 65
Query: 247 VSSIRQEG 254
++ +R EG
Sbjct: 66 LTMVRTEG 73
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 98.6 bits (244), Expect = 6e-21
Identities = 79/299 (26%), Positives = 128/299 (42%), Gaps = 36/299 (12%)
Query: 7 VAGWISGALGLVLGHPFDTVKVRLQTQ----------TTYRGIVDCMVKIYRHESLLGFF 56
VAG +SG + L PFD +K+R Q Q Y GI+ +I + E F+
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 57 KGMSFPIASIAVVNSVLFG-VYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAY 115
KG P A + S+ +G V + +LT H+ + F+ G +
Sbjct: 80 KG-HVP----AQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATL 134
Query: 116 CLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDT 175
+ P D+++ R Q EP+ Y H +++R EGP+ ++G +
Sbjct: 135 TVHPVDVLRTRFAAQGEPKV--------YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIF 186
Query: 176 PTVGIYFITYEGLCRQYT----PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQM 231
P G+ F Y L Y EG+ + L+ G AG+ S PLD+ K R+Q+
Sbjct: 187 PYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQV 246
Query: 232 DGLRR--------RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
G R Y+G++DC +++EG FF+G++ + +A F SYE+
Sbjct: 247 GGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
Score = 70.1 bits (170), Expect = 2e-12
Identities = 47/191 (24%), Positives = 87/191 (45%), Gaps = 9/191 (4%)
Query: 102 IFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPR 161
+ +AG G + ++PFD+IK+R Q Q E R P +Y G + + I +EEGP
Sbjct: 18 VAVAGSVSGLVTRALISPFDVIKIRFQLQHE-RLSRSDPSAKYHGILQASRQILQEEGPT 76
Query: 162 GLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVA 218
++G + + F+++E + + G + + V GG A + +
Sbjct: 77 AFWKGHVPAQILSIGYGAVQFLSFE-MLTELVHRGSVYDAREFSVHFVCGGLAACMATLT 135
Query: 219 ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFL 278
P+D++++R G +VY + + + R EG VF++G+ FP + F
Sbjct: 136 VHPVDVLRTRFAAQG-EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
Query: 279 SY---EYLLRW 286
Y ++L +W
Sbjct: 195 CYSSLKHLYKW 205
Score = 62.4 bits (150), Expect = 4e-10
Identities = 47/191 (24%), Positives = 78/191 (40%), Gaps = 6/191 (3%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQ---TTYRGIVDCMVKIYRHESLLGFFKGMSFP 62
FV G ++ + + HP D ++ R Q Y + + +YR E F+KG++
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPT 181
Query: 63 IASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDL 122
+ +I + F YS+ + E + + L G G + P DL
Sbjct: 182 LIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKN--ENLQNLLCGSGAGVISKTLTYPLDL 239
Query: 123 IKVRLQNQTEPRAQPG-SPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIY 181
K RLQ A+ RY+G + CA + ++EG G F+G L+ + G
Sbjct: 240 FKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFM 299
Query: 182 FITYEGLCRQY 192
F +YE C +
Sbjct: 300 FFSYEFFCNVF 310
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 6/96 (6%)
Query: 194 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLR------RRVYQGMLDCMV 247
P+G+N + V VAG +G+ + +P D+IK R Q+ R Y G+L
Sbjct: 8 PDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
Query: 248 SSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 283
+++EG F++G + AV FLS+E L
Sbjct: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEML 103
Score = 42.4 bits (98), Expect = 5e-04
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 12/87 (13%)
Query: 3 VEEFVAGWISGALGLVLGHPFDTVKVRLQT------------QTTYRGIVDCMVKIYRHE 50
++ + G +G + L +P D K RLQ Y+G++DC ++ + E
Sbjct: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE 276
Query: 51 SLLGFFKGMSFPIASIAVVNSVLFGVY 77
LGFFKG+S + A+ +F Y
Sbjct: 277 GALGFFKGLSPSLLKAALSTGFMFFSY 303
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 98.6 bits (244), Expect = 6e-21
Identities = 79/299 (26%), Positives = 128/299 (42%), Gaps = 36/299 (12%)
Query: 7 VAGWISGALGLVLGHPFDTVKVRLQTQ----------TTYRGIVDCMVKIYRHESLLGFF 56
VAG +SG + L PFD +K+R Q Q Y GI+ +I + E F+
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 57 KGMSFPIASIAVVNSVLFG-VYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAY 115
KG P A + S+ +G V + +LT H+ + F+ G +
Sbjct: 80 KG-HVP----AQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATL 134
Query: 116 CLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDT 175
+ P D+++ R Q EP+ Y H +++R EGP+ ++G +
Sbjct: 135 TVHPVDVLRTRFAAQGEPKV--------YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIF 186
Query: 176 PTVGIYFITYEGLCRQYT----PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQM 231
P G+ F Y L Y EG+ + L+ G AG+ S PLD+ K R+Q+
Sbjct: 187 PYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQV 246
Query: 232 DGLRR--------RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
G R Y+G++DC +++EG FF+G++ + +A F SYE+
Sbjct: 247 GGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
Score = 70.1 bits (170), Expect = 2e-12
Identities = 47/191 (24%), Positives = 87/191 (45%), Gaps = 9/191 (4%)
Query: 102 IFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPR 161
+ +AG G + ++PFD+IK+R Q Q E R P +Y G + + I +EEGP
Sbjct: 18 VAVAGSVSGLVTRALISPFDVIKIRFQLQHE-RLSRSDPSAKYHGILQASRQILQEEGPT 76
Query: 162 GLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVA 218
++G + + F+++E + + G + + V GG A + +
Sbjct: 77 AFWKGHVPAQILSIGYGAVQFLSFE-MLTELVHRGSVYDAREFSVHFVCGGLAACMATLT 135
Query: 219 ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFL 278
P+D++++R G +VY + + + R EG VF++G+ FP + F
Sbjct: 136 VHPVDVLRTRFAAQG-EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
Query: 279 SY---EYLLRW 286
Y ++L +W
Sbjct: 195 CYSSLKHLYKW 205
Score = 62.4 bits (150), Expect = 4e-10
Identities = 47/191 (24%), Positives = 78/191 (40%), Gaps = 6/191 (3%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQ---TTYRGIVDCMVKIYRHESLLGFFKGMSFP 62
FV G ++ + + HP D ++ R Q Y + + +YR E F+KG++
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPT 181
Query: 63 IASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDL 122
+ +I + F YS+ + E + + L G G + P DL
Sbjct: 182 LIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKN--ENLQNLLCGSGAGVISKTLTYPLDL 239
Query: 123 IKVRLQNQTEPRAQPG-SPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIY 181
K RLQ A+ RY+G + CA + ++EG G F+G L+ + G
Sbjct: 240 FKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFM 299
Query: 182 FITYEGLCRQY 192
F +YE C +
Sbjct: 300 FFSYEFFCNVF 310
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 6/96 (6%)
Query: 194 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLR------RRVYQGMLDCMV 247
P+G+N + V VAG +G+ + +P D+IK R Q+ R Y G+L
Sbjct: 8 PDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
Query: 248 SSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 283
+++EG F++G + AV FLS+E L
Sbjct: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEML 103
Score = 42.4 bits (98), Expect = 5e-04
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 12/87 (13%)
Query: 3 VEEFVAGWISGALGLVLGHPFDTVKVRLQT------------QTTYRGIVDCMVKIYRHE 50
++ + G +G + L +P D K RLQ Y+G++DC ++ + E
Sbjct: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE 276
Query: 51 SLLGFFKGMSFPIASIAVVNSVLFGVY 77
LGFFKG+S + A+ +F Y
Sbjct: 277 GALGFFKGLSPSLLKAALSTGFMFFSY 303
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 98.6 bits (244), Expect = 6e-21
Identities = 79/299 (26%), Positives = 128/299 (42%), Gaps = 36/299 (12%)
Query: 7 VAGWISGALGLVLGHPFDTVKVRLQTQ----------TTYRGIVDCMVKIYRHESLLGFF 56
VAG +SG + L PFD +K+R Q Q Y GI+ +I + E F+
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 57 KGMSFPIASIAVVNSVLFG-VYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAY 115
KG P A + S+ +G V + +LT H+ + F+ G +
Sbjct: 80 KG-HVP----AQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATL 134
Query: 116 CLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDT 175
+ P D+++ R Q EP+ Y H +++R EGP+ ++G +
Sbjct: 135 TVHPVDVLRTRFAAQGEPKV--------YNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIF 186
Query: 176 PTVGIYFITYEGLCRQYT----PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQM 231
P G+ F Y L Y EG+ + L+ G AG+ S PLD+ K R+Q+
Sbjct: 187 PYAGLQFSCYSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQV 246
Query: 232 DGLRR--------RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
G R Y+G++DC +++EG FF+G++ + +A F SYE+
Sbjct: 247 GGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEF 305
Score = 70.1 bits (170), Expect = 2e-12
Identities = 47/191 (24%), Positives = 87/191 (45%), Gaps = 9/191 (4%)
Query: 102 IFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPR 161
+ +AG G + ++PFD+IK+R Q Q E R P +Y G + + I +EEGP
Sbjct: 18 VAVAGSVSGLVTRALISPFDVIKIRFQLQHE-RLSRSDPSAKYHGILQASRQILQEEGPT 76
Query: 162 GLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSS---ATVLVAGGFAGIASWVA 218
++G + + F+++E + + G + + V GG A + +
Sbjct: 77 AFWKGHVPAQILSIGYGAVQFLSFE-MLTELVHRGSVYDAREFSVHFVCGGLAACMATLT 135
Query: 219 ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFL 278
P+D++++R G +VY + + + R EG VF++G+ FP + F
Sbjct: 136 VHPVDVLRTRFAAQG-EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFS 194
Query: 279 SY---EYLLRW 286
Y ++L +W
Sbjct: 195 CYSSLKHLYKW 205
Score = 62.4 bits (150), Expect = 4e-10
Identities = 47/191 (24%), Positives = 78/191 (40%), Gaps = 6/191 (3%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQ---TTYRGIVDCMVKIYRHESLLGFFKGMSFP 62
FV G ++ + + HP D ++ R Q Y + + +YR E F+KG++
Sbjct: 122 FVCGGLAACMATLTVHPVDVLRTRFAAQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPT 181
Query: 63 IASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDL 122
+ +I + F YS+ + E + + L G G + P DL
Sbjct: 182 LIAIFPYAGLQFSCYSSLKHLYKWAIPAEGKKN--ENLQNLLCGSGAGVISKTLTYPLDL 239
Query: 123 IKVRLQNQTEPRAQPG-SPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIY 181
K RLQ A+ RY+G + CA + ++EG G F+G L+ + G
Sbjct: 240 FKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFM 299
Query: 182 FITYEGLCRQY 192
F +YE C +
Sbjct: 300 FFSYEFFCNVF 310
Score = 46.6 bits (109), Expect = 3e-05
Identities = 29/96 (30%), Positives = 46/96 (47%), Gaps = 6/96 (6%)
Query: 194 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLR------RRVYQGMLDCMV 247
P+G+N + V VAG +G+ + +P D+IK R Q+ R Y G+L
Sbjct: 8 PDGRNNTKFQVAVAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASR 67
Query: 248 SSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 283
+++EG F++G + AV FLS+E L
Sbjct: 68 QILQEEGPTAFWKGHVPAQILSIGYGAVQFLSFEML 103
Score = 42.4 bits (98), Expect = 5e-04
Identities = 24/87 (27%), Positives = 40/87 (45%), Gaps = 12/87 (13%)
Query: 3 VEEFVAGWISGALGLVLGHPFDTVKVRLQT------------QTTYRGIVDCMVKIYRHE 50
++ + G +G + L +P D K RLQ Y+G++DC ++ + E
Sbjct: 217 LQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYKGLMDCAKQVLQKE 276
Query: 51 SLLGFFKGMSFPIASIAVVNSVLFGVY 77
LGFFKG+S + A+ +F Y
Sbjct: 277 GALGFFKGLSPSLLKAALSTGFMFFSY 303
>gi|13899342 solute carrier [Homo sapiens]
Length = 315
Score = 97.8 bits (242), Expect = 1e-20
Identities = 77/279 (27%), Positives = 116/279 (41%), Gaps = 28/279 (10%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQ---TTYRGIVDCMVKIYRHESLLGFFKGMSF 61
+ + G ++G +G+ P D K RLQ Q Y+G++DC++K R E G ++G +
Sbjct: 11 KLINGGVAGLVGVTCVFPIDLAKTRLQNQHGKAMYKGMIDCLMKTARAEGFFGMYRGAAV 70
Query: 62 PIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFD 121
+ + ++ +L Q LAGC G Q P +
Sbjct: 71 NLTLVTPEKAIKLAANDFFRRLLMEDGMQRNLKME------MLAGCGAGMCQVVVTCPME 124
Query: 122 LIKVRLQN---------------QTEPRAQPGSPPP-RYQGPVHCAASIFREEGPRGLFR 165
++K++LQ+ T GS R A + R +G GL+R
Sbjct: 125 MLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAGLYR 184
Query: 166 GAWALTLRDTPTVGIYFITYEGLCR-QYTPEGQNPSSATVLVAGGFAGIASWVAATPLDM 224
G A LRD P IYF + L + S A V+G AG + VA TPLD+
Sbjct: 185 GLGATLLRDIPFSIIYFPLFANLNNLGFNELAGKASFAHSFVSGCVAGSIAAVAVTPLDV 244
Query: 225 IKSRMQ--MDGLRRRVYQGMLDCMVSSIRQEGLGVFFRG 261
+K+R+Q GL +Y G+ DC QEG F +G
Sbjct: 245 LKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKG 283
Score = 56.2 bits (134), Expect = 3e-08
Identities = 48/195 (24%), Positives = 73/195 (37%), Gaps = 31/195 (15%)
Query: 106 GCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFR 165
G G + C+ P DL K RLQNQ Y+G + C R EG G++R
Sbjct: 15 GGVAGLVGVTCVFPIDLAKTRLQNQ--------HGKAMYKGMIDCLMKTARAEGFFGMYR 66
Query: 166 GAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMI 225
GA TP I + R +G + ++AG AG+ V P++M+
Sbjct: 67 GAAVNLTLVTPEKAIKLAANDFFRRLLMEDGMQRNLKMEMLAGCGAGMCQVVVTCPMEML 126
Query: 226 KSRMQMDGLRRRVYQGMLDCMVSS-----------------------IRQEGLGVFFRGV 262
K ++Q G +QG +S +R +GL +RG+
Sbjct: 127 KIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQGLAGLYRGL 186
Query: 263 TINSARAFPVNAVTF 277
R P + + F
Sbjct: 187 GATLLRDIPFSIIYF 201
Score = 55.8 bits (133), Expect = 4e-08
Identities = 38/143 (26%), Positives = 63/143 (44%), Gaps = 14/143 (9%)
Query: 45 KIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFL 104
++ R + L G ++G+ + + + F +++N L E A S+ H F+
Sbjct: 172 ELLRTQGLAGLYRGLGATLLRDIPFSIIYFPLFAN----LNNLGFNEL-AGKASFAHSFV 226
Query: 105 AGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLF 164
+GC G + A + P D++K R+Q + G Y G CA ++ +EGP
Sbjct: 227 SGCVAGSIAAVAVTPLDVLKTRIQT-----LKKGLGEDMYSGITDCARKLWIQEGPSAFM 281
Query: 165 RGAWALTLRDTPTVGI----YFI 183
+GA L P GI YFI
Sbjct: 282 KGAGCRALVIAPLFGIAQGVYFI 304
Score = 53.1 bits (126), Expect = 3e-07
Identities = 26/89 (29%), Positives = 46/89 (51%), Gaps = 1/89 (1%)
Query: 197 QNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLG 256
Q+ S L+ GG AG+ P+D+ K+R+Q + +Y+GM+DC++ + R EG
Sbjct: 4 QDLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQNQH-GKAMYKGMIDCLMKTARAEGFF 62
Query: 257 VFFRGVTINSARAFPVNAVTFLSYEYLLR 285
+RG +N P A+ + ++ R
Sbjct: 63 GMYRGAAVNLTLVTPEKAIKLAANDFFRR 91
Score = 45.1 bits (105), Expect = 7e-05
Identities = 26/78 (33%), Positives = 38/78 (48%), Gaps = 6/78 (7%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQT------QTTYRGIVDCMVKIYRHESLLGFFKGM 59
FV+G ++G++ V P D +K R+QT + Y GI DC K++ E F KG
Sbjct: 225 FVSGCVAGSIAAVAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKGA 284
Query: 60 SFPIASIAVVNSVLFGVY 77
IA + + GVY
Sbjct: 285 GCRALVIAPLFGIAQGVY 302
>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
Length = 315
Score = 95.5 bits (236), Expect = 5e-20
Identities = 78/290 (26%), Positives = 132/290 (45%), Gaps = 24/290 (8%)
Query: 4 EEFVAGWISGALGLVLGHPFDTVKVR------LQTQTTYRGIVDCMVKIYRHESLLGFFK 57
E +AG G L + HP D VK+R L+ + Y GI+ C+ I++ + L G ++
Sbjct: 24 ENLIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQ 83
Query: 58 GMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCL 117
G++ I + + F Y+ T E RA+ ++ G +
Sbjct: 84 GVTPNIWGAGLSWGLYFFFYNAIKSYKT-----EGRAERLEATEYLVSAAEAGAMTLCIT 138
Query: 118 APFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPT 177
P + K RL Q + A SP +Y+G I++ EG RGL++G + L T
Sbjct: 139 NPLWVTKTRLMLQYD--AVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKG-FVPGLFGTSH 195
Query: 178 VGIYFITYEGLCRQYT------PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQM 231
+ F+ YE L +Y PE Q + + VA + I + A P ++++R+Q
Sbjct: 196 GALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAA-LSKIFAVAATYPYQVVRARLQD 254
Query: 232 DGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 281
+ Y G++D + + R+EG+G F++G+ N R P +TF+ YE
Sbjct: 255 QHM---FYSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYE 301
Score = 58.2 bits (139), Expect = 8e-09
Identities = 51/196 (26%), Positives = 84/196 (42%), Gaps = 25/196 (12%)
Query: 4 EEFVAGWISGALGLVLGHPFDTVKVRLQTQ---------TTYRGIVDCMVKIYRHESLLG 54
E V+ +GA+ L + +P K RL Q Y+G+ D +VKIY++E + G
Sbjct: 122 EYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRG 181
Query: 55 FFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQER--RAQPPSYMHIFLAGCTGGFL 112
+KG + + + + LL L H R AQ + +I +A + F
Sbjct: 182 LYKGF---VPGLFGTSHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFA 238
Query: 113 QAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTL 172
A P+ +++ RLQ+Q Y G + +R+EG G ++G +
Sbjct: 239 VA-ATYPYQVVRARLQDQHM----------FYSGVIDVITKTWRKEGVGGFYKGIAPNLI 287
Query: 173 RDTPTVGIYFITYEGL 188
R TP I F+ YE +
Sbjct: 288 RVTPACCITFVVYENV 303
Score = 43.5 bits (101), Expect = 2e-04
Identities = 23/78 (29%), Positives = 39/78 (50%), Gaps = 1/78 (1%)
Query: 3 VEEFVAGWISGALGLVLGHPFDTVKVRLQTQTT-YRGIVDCMVKIYRHESLLGFFKGMSF 61
VE +S + +P+ V+ RLQ Q Y G++D + K +R E + GF+KG++
Sbjct: 225 VEYISVAALSKIFAVAATYPYQVVRARLQDQHMFYSGVIDVITKTWRKEGVGGFYKGIAP 284
Query: 62 PIASIAVVNSVLFGVYSN 79
+ + + F VY N
Sbjct: 285 NLIRVTPACCITFVVYEN 302
>gi|149274643 solute carrier family 25, member 28 [Homo sapiens]
Length = 364
Score = 88.6 bits (218), Expect = 6e-18
Identities = 72/290 (24%), Positives = 121/290 (41%), Gaps = 32/290 (11%)
Query: 7 VAGWISGALGLVLGHPFDTVKVRLQT-----QTTYRGIVDCMVKIYRHESLLGFFKGMSF 61
VAG ++G L + +P D VK R+Q+ YR +++ + +I R E L +G++
Sbjct: 77 VAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAARYRNVLEALWRIIRTEGLWRPMRGLNV 136
Query: 62 PIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIF--LAGCTGGFLQAYCLAP 119
+++ F Y L+ H P HI AGC L + P
Sbjct: 137 TATGAGPAHALYFACYEKLKKTLSDVIH------PGGNSHIANGAAGCVATLLHDAAMNP 190
Query: 120 FDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVG 179
+++K R+Q P Y C ++++ EG +R + P
Sbjct: 191 AEVVKQRMQMYNSP----------YHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQA 240
Query: 180 IYFITYEGLCRQYTPEGQ-NPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMD---GLR 235
I+F+TYE L + P+ + NPSS +++G AG + A TPLD+ K+ + L
Sbjct: 241 IHFMTYEFLQEHFNPQRRYNPSSH--VLSGACAGAVAAAATTPLDVCKTLLNTQESLALN 298
Query: 236 RRV---YQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
+ GM + + G+ +FRGV P A+ + YE+
Sbjct: 299 SHITGHITGMASAFRTVYQVGGVTAYFRGVQARVIYQIPSTAIAWSVYEF 348
Score = 68.6 bits (166), Expect = 6e-12
Identities = 54/183 (29%), Positives = 78/183 (42%), Gaps = 13/183 (7%)
Query: 104 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 163
+AG G L+ + P D +K R+Q+ QP P RY+ + I R EG
Sbjct: 77 VAGAVAGILEHCVMYPIDCVKTRMQS-----LQP-DPAARYRNVLEALWRIIRTEGLWRP 130
Query: 164 FRGAWALTLRDTPTVGIYFITYEGLCRQYTP---EGQNPSSATVLVAGGFAGIASWVAAT 220
RG P +YF YE L + + G N A AG A + A
Sbjct: 131 MRGLNVTATGAGPAHALYFACYEKLKKTLSDVIHPGGNSHIANG-AAGCVATLLHDAAMN 189
Query: 221 PLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSY 280
P +++K RMQM Y + DC+ + + EG G F+R T P A+ F++Y
Sbjct: 190 PAEVVKQRMQM---YNSPYHRVTDCVRAVWQNEGAGAFYRSYTTQLTMNVPFQAIHFMTY 246
Query: 281 EYL 283
E+L
Sbjct: 247 EFL 249
Score = 48.9 bits (115), Expect = 5e-06
Identities = 34/91 (37%), Positives = 48/91 (52%), Gaps = 8/91 (8%)
Query: 199 PSSATV---LVAGGFAGIASWVAATPLDMIKSRMQM---DGLRRRVYQGMLDCMVSSIRQ 252
P+ ATV +VAG AGI P+D +K+RMQ D R Y+ +L+ + IR
Sbjct: 67 PAGATVTTHMVAGAVAGILEHCVMYPIDCVKTRMQSLQPDPAAR--YRNVLEALWRIIRT 124
Query: 253 EGLGVFFRGVTINSARAFPVNAVTFLSYEYL 283
EGL RG+ + + A P +A+ F YE L
Sbjct: 125 EGLWRPMRGLNVTATGAGPAHALYFACYEKL 155
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 87.4 bits (215), Expect = 1e-17
Identities = 71/269 (26%), Positives = 113/269 (42%), Gaps = 21/269 (7%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQ-----------TTYRGIVDCMVKIYRHESLL 53
+F+ + ++ P DT KVRLQ Q YRG++ ++ + R E
Sbjct: 16 KFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPC 75
Query: 54 GFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQ 113
+ G+ + S+ G+Y + V T + A S LAGCT G +
Sbjct: 76 SPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTP-----KGADNSSLTTRILAGCTTGAMA 130
Query: 114 AYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLR 173
C P D++KVR Q P +Y G + +I REEG RGL++G +R
Sbjct: 131 VTCAQPTDVVKVRFQASIH--LGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMR 188
Query: 174 DTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGF-AGIASWVAATPLDMIKSRMQMD 232
+ +TY+ L + + F AG + V A+P+D++K+R
Sbjct: 189 NAIVNCAEVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFCATVVASPVDVVKTRYMNS 248
Query: 233 GLRRRVYQGMLDCMVSSIRQEGLGVFFRG 261
+ Y LDCM+ + QEG F++G
Sbjct: 249 PPGQ--YFSPLDCMIKMVAQEGPTAFYKG 275
Score = 72.4 bits (176), Expect = 4e-13
Identities = 58/194 (29%), Positives = 86/194 (44%), Gaps = 6/194 (3%)
Query: 96 PPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIF 155
PP+ FL T P D KVRLQ Q E +A + +Y+G + ++
Sbjct: 10 PPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMV 69
Query: 156 REEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATV-LVAGGFAGIA 214
R EGP + G A R I Y+ + + YTP+G + SS T ++AG G
Sbjct: 70 RTEGPCSPYNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTGAM 129
Query: 215 SWVAATPLDMIKSRMQMD---GLRR--RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARA 269
+ A P D++K R Q G R R Y G +D + R+EG+ ++G N R
Sbjct: 130 AVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRN 189
Query: 270 FPVNAVTFLSYEYL 283
VN ++Y+ L
Sbjct: 190 AIVNCAEVVTYDIL 203
Score = 31.6 bits (70), Expect = 0.84
Identities = 19/68 (27%), Positives = 32/68 (47%), Gaps = 7/68 (10%)
Query: 194 PEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRV-------YQGMLDCM 246
P P+ A + G A + + PLD K R+Q+ G + V Y+G+L +
Sbjct: 6 PSDVPPTMAVKFLGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTI 65
Query: 247 VSSIRQEG 254
++ +R EG
Sbjct: 66 LTMVRTEG 73
>gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
Length = 332
Score = 87.4 bits (215), Expect = 1e-17
Identities = 76/306 (24%), Positives = 127/306 (41%), Gaps = 34/306 (11%)
Query: 3 VEEFVAGWISGALGLVLGHPFDTVKVRLQTQT---TYRGIVDCMVKIYRHESLLGFFKGM 59
+ F+AG I+G P D VKV LQ + G+ + + + E LG +KG
Sbjct: 37 LRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGN 96
Query: 60 SFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAP 119
+ I ++ F + + ++T + ++H +AG G C P
Sbjct: 97 GAMMIRIFPYGAIQFMAFEHYKTLITT------KLGISGHVHRLMAGSMAGMTAVICTYP 150
Query: 120 FDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPR-GLFRGAWALTLRDTPTV 178
D+++VRL Q + Y G +H +I+ +EG G +RG L P
Sbjct: 151 LDMVRVRLAFQVKGEHS-------YTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYA 203
Query: 179 GIYFITYE-----GLCRQYT----PEGQNPSSATV-----LVAGGFAGIASWVAATPLDM 224
G+ F T+ GL T P NP+ + L+ GG AG + + P D+
Sbjct: 204 GVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAGAIAQTISYPFDV 263
Query: 225 IKSRMQMDGLRRRVYQ--GMLDCMVSSIRQEGLGV-FFRGVTINSARAFPVNAVTFLSYE 281
+ RMQ+ + + M D M G+ +RG+++N R P AV F +YE
Sbjct: 264 TRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGLSLNYIRCIPSQAVAFTTYE 323
Query: 282 YLLRWW 287
+ +++
Sbjct: 324 LMKQFF 329
Score = 57.0 bits (136), Expect = 2e-08
Identities = 45/183 (24%), Positives = 78/183 (42%), Gaps = 9/183 (4%)
Query: 99 YMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREE 158
++ FLAG G +AP D +KV LQ ++ G ++ ++E
Sbjct: 36 WLRSFLAGGIAGCCAKTTVAPLDRVKVLLQAHNHHY--------KHLGVFSALRAVPQKE 87
Query: 159 GPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVA 218
G GL++G A+ +R P I F+ +E T + L+AG AG+ + +
Sbjct: 88 GFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGHVHRLMAGSMAGMTAVIC 147
Query: 219 ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQE-GLGVFFRGVTINSARAFPVNAVTF 277
PLDM++ R+ Y G++ + +E G F+RG+ P V+F
Sbjct: 148 TYPLDMVRVRLAFQVKGEHSYTGIIHAFKTIYAKEGGFFGFYRGLMPTILGMAPYAGVSF 207
Query: 278 LSY 280
++
Sbjct: 208 FTF 210
>gi|82775373 solute carrier family 25, member 37 [Homo sapiens]
Length = 338
Score = 87.0 bits (214), Expect = 2e-17
Identities = 74/288 (25%), Positives = 122/288 (42%), Gaps = 29/288 (10%)
Query: 8 AGWISGALGLVLGHPFDTVKVRLQT-----QTTYRGIVDCMVKIYRHESLLGFFKGMSFP 62
AG ++G L + +P D+VK R+Q+ + Y I + KI R E +G++
Sbjct: 51 AGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEGFWRPLRGVNVM 110
Query: 63 IASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDL 122
I +++ F Y N L H Q S++ +AG L + P ++
Sbjct: 111 IMGAGPAHAMYFACYENMKRTLNDVFHH----QGNSHLANGIAGSMATLLHDAVMNPAEV 166
Query: 123 IKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYF 182
+K RLQ +++ + C +++R EG +R + P I+F
Sbjct: 167 VKQRLQMYNS----------QHRSAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHF 216
Query: 183 ITYEGLCRQYTP-EGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMD---GLRRRV 238
ITYE L Q P NP S +++GG AG + A TPLD+ K+ + L
Sbjct: 217 ITYEFLQEQVNPHRTYNPQSH--IISGGLAGALAAAATTPLDVCKTLLNTQENVALSLAN 274
Query: 239 YQGMLDCMVSSIRQ----EGLGVFFRGVTINSARAFPVNAVTFLSYEY 282
G L M ++ R GL +F+G+ P A+++ YE+
Sbjct: 275 ISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVYEF 322
Score = 68.2 bits (165), Expect = 8e-12
Identities = 50/182 (27%), Positives = 78/182 (42%), Gaps = 13/182 (7%)
Query: 105 AGCTGGFLQAYCLAPFDLIKVRLQNQT-EPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 163
AG G L+ + P D +K R+Q+ + +P+AQ Y I R EG
Sbjct: 51 AGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQ-------YTSIYGALKKIMRTEGFWRP 103
Query: 164 FRGAWALTLRDTPTVGIYFITYEGLCRQYTP--EGQNPSSATVLVAGGFAGIASWVAATP 221
RG + + P +YF YE + R Q S +AG A + P
Sbjct: 104 LRGVNVMIMGAGPAHAMYFACYENMKRTLNDVFHHQGNSHLANGIAGSMATLLHDAVMNP 163
Query: 222 LDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 281
+++K R+QM + R + C+ + R EGLG F+R T P ++ F++YE
Sbjct: 164 AEVVKQRLQMYNSQHR---SAISCIRTVWRTEGLGAFYRSYTTQLTMNIPFQSIHFITYE 220
Query: 282 YL 283
+L
Sbjct: 221 FL 222
Score = 52.4 bits (124), Expect = 5e-07
Identities = 42/181 (23%), Positives = 75/181 (41%), Gaps = 8/181 (4%)
Query: 7 VAGWISGALGLVLGHPFDTVKVRLQTQTT-YRGIVDCMVKIYRHESLLGFFKGMSFPIAS 65
+AG ++ L + +P + VK RLQ + +R + C+ ++R E L F++ + +
Sbjct: 148 IAGSMATLLHDAVMNPAEVVKQRLQMYNSQHRSAISCIRTVWRTEGLGAFYRSYTTQLTM 207
Query: 66 IAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKV 125
S+ F Y L + R P S++ ++G G L A P D+ K
Sbjct: 208 NIPFQSIHFITYE----FLQEQVNPHRTYNPQSHI---ISGGLAGALAAAATTPLDVCKT 260
Query: 126 RLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITY 185
L Q + R G + ++++ G G F+G A + P+ I + Y
Sbjct: 261 LLNTQENVALSLANISGRLSGMANAFRTVYQLNGLAGYFKGIQARVIYQMPSTAISWSVY 320
Query: 186 E 186
E
Sbjct: 321 E 321
Score = 41.2 bits (95), Expect = 0.001
Identities = 29/91 (31%), Positives = 44/91 (48%), Gaps = 4/91 (4%)
Query: 199 PSSATV---LVAGGFAGIASWVAATPLDMIKSRMQ-MDGLRRRVYQGMLDCMVSSIRQEG 254
P+SA+V + AG AGI P+D +K+RMQ + + Y + + +R EG
Sbjct: 40 PTSASVSTHMTAGAMAGILEHSVMYPVDSVKTRMQSLSPDPKAQYTSIYGALKKIMRTEG 99
Query: 255 LGVFFRGVTINSARAFPVNAVTFLSYEYLLR 285
RGV + A P +A+ F YE + R
Sbjct: 100 FWRPLRGVNVMIMGAGPAHAMYFACYENMKR 130
Score = 33.1 bits (74), Expect = 0.29
Identities = 23/102 (22%), Positives = 38/102 (37%), Gaps = 11/102 (10%)
Query: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTT-----------YRGIVDCMVKIYRHE 50
P ++G ++GAL P D K L TQ G+ + +Y+
Sbjct: 234 PQSHIISGGLAGALAAAATTPLDVCKTLLNTQENVALSLANISGRLSGMANAFRTVYQLN 293
Query: 51 SLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQER 92
L G+FKG+ + ++ + VY LT + R
Sbjct: 294 GLAGYFKGIQARVIYQMPSTAISWSVYEFFKYFLTKRQLENR 335
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 86.7 bits (213), Expect = 2e-17
Identities = 81/297 (27%), Positives = 124/297 (41%), Gaps = 32/297 (10%)
Query: 5 EFVAGWISGALGLVLGHPFDTVKVRLQTQ------------TTYRGIVDCMVKIYRHESL 52
+F+ + + ++ P DT KVRLQ Q YRG++ ++ + R E
Sbjct: 16 KFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGP 75
Query: 53 LGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFL 112
+ G+ + SV G+Y + T S S LAG T G L
Sbjct: 76 RSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHA------SIGSRLLAGSTTGAL 129
Query: 113 QAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTL 172
P D++KVR Q Q RA G RYQ V+ +I REEG RGL++G
Sbjct: 130 AVAVAQPTDVVKVRFQAQA--RAGGGR---RYQSTVNAYKTIAREEGFRGLWKGTSPNVA 184
Query: 173 RDTPTVGIYFITYE----GLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSR 228
R+ +TY+ L + P T GF + V A+P+D++K+R
Sbjct: 185 RNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFC---TTVIASPVDVVKTR 241
Query: 229 MQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLR 285
L + Y C ++ +++EG F++G + R N V F++YE L R
Sbjct: 242 YMNSALGQ--YSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKR 296
Score = 71.2 bits (173), Expect = 1e-12
Identities = 52/191 (27%), Positives = 84/191 (43%), Gaps = 3/191 (1%)
Query: 96 PPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQP-GSPPPRYQGPVHCAASI 154
PP+ FL T + P D KVRLQ Q E + + +Y+G + ++
Sbjct: 10 PPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTM 69
Query: 155 FREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIA 214
R EGPR L+ G A R + Y+ + + YT ++ S + L+AG G
Sbjct: 70 VRTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGAL 129
Query: 215 SWVAATPLDMIKSRMQMDGLR--RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPV 272
+ A P D++K R Q R YQ ++ + R+EG ++G + N AR V
Sbjct: 130 AVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIV 189
Query: 273 NAVTFLSYEYL 283
N ++Y+ +
Sbjct: 190 NCAELVTYDLI 200
Score = 28.1 bits (61), Expect = 9.3
Identities = 20/83 (24%), Positives = 30/83 (36%), Gaps = 2/83 (2%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQTT--YRGIVDCMVKIYRHESLLGFFKGMSFPI 63
F + + +G V+ P D VK R Y C + + + E F+KG
Sbjct: 218 FTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSF 277
Query: 64 ASIAVVNSVLFGVYSNTLLVLTA 86
+ N V+F Y L A
Sbjct: 278 LRLGSWNVVMFVTYEQLKRALMA 300
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 86.3 bits (212), Expect = 3e-17
Identities = 69/289 (23%), Positives = 124/289 (42%), Gaps = 29/289 (10%)
Query: 4 EEFVAGWISGALGLVLGHPFDTVKVRLQ---TQTTYRGIVDCMVKIYRHESLLGFFKGMS 60
++ VAG ++GA+ P D +KV +Q ++T I+ + + + ++G
Sbjct: 187 KQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNILGGLRSMVLEGGIRSLWRGNG 246
Query: 61 FPIASIAVVNSVLFGVYSN---TLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCL 117
+ IA +++ F Y +L T H + R F+AG G +
Sbjct: 247 INVLKIAPESAIKFMAYEQIKRAILGQQETLHVQER---------FVAGSLAGATAQTII 297
Query: 118 APFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPT 177
P +++K RL + + Y+G + CA I EGPR +RG L P
Sbjct: 298 YPMEVLKTRLTLRRTGQ---------YKGLLDCARRILEREGPRAFYRGYLPNVLGIIPY 348
Query: 178 VGIYFITYEGL----CRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMD- 232
GI YE L +QY+ + +P +L G + +A+ PL ++++RMQ
Sbjct: 349 AGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQA 408
Query: 233 GLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 281
+ ML + + QEG+ +RG+ N + P +++++ YE
Sbjct: 409 SIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYE 457
Score = 66.2 bits (160), Expect = 3e-11
Identities = 49/184 (26%), Positives = 76/184 (41%), Gaps = 10/184 (5%)
Query: 104 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 163
+AG G + AP D +KV +Q + + S+ E G R L
Sbjct: 190 VAGAVAGAVSRTGTAPLDRLKVFMQVHASKTNRLNI--------LGGLRSMVLEGGIRSL 241
Query: 164 FRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLD 223
+RG L+ P I F+ YE + R + + VAG AG + P++
Sbjct: 242 WRGNGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAGATAQTIIYPME 301
Query: 224 MIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 283
++K+R+ + R Y+G+LDC + +EG F+RG N P + YE L
Sbjct: 302 VLKTRLTLR--RTGQYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETL 359
Query: 284 LRWW 287
WW
Sbjct: 360 KNWW 363
Score = 60.8 bits (146), Expect = 1e-09
Identities = 49/188 (26%), Positives = 78/188 (41%), Gaps = 12/188 (6%)
Query: 4 EEFVAGWISGALGLVLGHPFDTVKVRLQTQTT--YRGIVDCMVKIYRHESLLGFFKGMSF 61
E FVAG ++GA + +P + +K RL + T Y+G++DC +I E F++G
Sbjct: 281 ERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCARRILEREGPRAFYRGYLP 340
Query: 62 PIASIAVVNSVLFGVYSNTL-LVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPF 120
+ I + VY L SH + P + + G P
Sbjct: 341 NVLGIIPYAGIDLAVYETLKNWWLQQYSHD---SADPGILVLLACGTISSTCGQIASYPL 397
Query: 121 DLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGI 180
L++ R+Q Q G P G + I +EG RGL+RG ++ P V I
Sbjct: 398 ALVRTRMQAQASIE---GGPQLSMLGLLR---HILSQEGMRGLYRGIAPNFMKVIPAVSI 451
Query: 181 YFITYEGL 188
++ YE +
Sbjct: 452 SYVVYENM 459
Score = 34.7 bits (78), Expect = 0.100
Identities = 23/85 (27%), Positives = 38/85 (44%), Gaps = 5/85 (5%)
Query: 9 GWISGALGLVLGHPFDTVKVRLQTQTTYRGIVDC-MVKIYRH----ESLLGFFKGMSFPI 63
G IS G + +P V+ R+Q Q + G M+ + RH E + G ++G++
Sbjct: 383 GTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNF 442
Query: 64 ASIAVVNSVLFGVYSNTLLVLTATS 88
+ S+ + VY N L TS
Sbjct: 443 MKVIPAVSISYVVYENMKQALGVTS 467
>gi|157388991 solute carrier family 25, member 36 isoform b [Homo
sapiens]
Length = 310
Score = 85.9 bits (211), Expect = 4e-17
Identities = 58/200 (29%), Positives = 97/200 (48%), Gaps = 15/200 (7%)
Query: 94 AQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQN--------QTEPRAQPGSPPPRY- 144
+Q + +H+F GC GG + A P +++K RLQ+ + + G+ R
Sbjct: 2 SQRDTLVHLFAGGC-GGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVV 60
Query: 145 -QGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSAT 203
GP+HC I +EGPR LFRG + P+ IYF Y C++ + +P S
Sbjct: 61 SPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSN-CKEKLNDVFDPDSTQ 119
Query: 204 V-LVAGGFAGIASWVAATPLDMIKSRMQMDGLRR-RVYQGMLDCMVSSIRQEGLGVFFRG 261
V +++ AG + A P+ +IK+R+Q+D R G +C+ + +GL F+RG
Sbjct: 120 VHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRG 179
Query: 262 VTINSARAFPVNAVTFLSYE 281
++ + A + F+ YE
Sbjct: 180 MSASYA-GISETVIHFVIYE 198
Score = 77.8 bits (190), Expect = 1e-14
Identities = 75/310 (24%), Positives = 124/310 (40%), Gaps = 49/310 (15%)
Query: 8 AGWISGALGLVLGHPFDTVKVRLQTQ--TTY-------------------RGIVDCMVKI 46
AG G +G +L P + VK RLQ+ T Y G + C+ I
Sbjct: 12 AGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCLKVI 71
Query: 47 YRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAG 106
E F+G+ + +A ++ F YSN L P S ++
Sbjct: 72 LEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVF------DPDSTQVHMISA 125
Query: 107 CTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRG 166
GF P LIK RLQ R + R G C +++ +G +G +RG
Sbjct: 126 AMAGFTAITATNPIWLIKTRLQLDARNRGE------RRMGAFECVRKVYQTDGLKGFYRG 179
Query: 167 AWALTLRDTPTVGIYFITYEGLCRQY----TPEGQNPSSATVLVAGGFAGI-----ASWV 217
A + TV I+F+ YE + ++ T +V A F G+ S
Sbjct: 180 MSASYAGISETV-IHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKT 238
Query: 218 AATPL---DMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNA 274
AT + ++++R++ +G + R + L +V ++EG G +RG+T + R P A
Sbjct: 239 CATTIAYPHVVRTRLREEGTKYRSFFQTLSLLV---QEEGYGSLYRGLTTHLVRQIPNTA 295
Query: 275 VTFLSYEYLL 284
+ +YE ++
Sbjct: 296 IMMATYELVV 305
Score = 52.4 bits (124), Expect = 5e-07
Identities = 45/191 (23%), Positives = 83/191 (43%), Gaps = 22/191 (11%)
Query: 7 VAGWISGALGLVLGHPFDTVKVRLQTQTTYRG-----IVDCMVKIYRHESLLGFFKGMSF 61
++ ++G + +P +K RLQ RG +C+ K+Y+ + L GF++GMS
Sbjct: 123 ISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSA 182
Query: 62 PIASIA--VVNSVLFGVYSNTLL----VLTATSHQERRAQPPSYMHIFLAGCTGGFLQAY 115
A I+ V++ V++ LL T + +E + ++ + LA T A
Sbjct: 183 SYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTC-AT 241
Query: 116 CLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDT 175
+A +++ RL+ + +Y+ + + +EEG L+RG +R
Sbjct: 242 TIAYPHVVRTRLREE----------GTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQI 291
Query: 176 PTVGIYFITYE 186
P I TYE
Sbjct: 292 PNTAIMMATYE 302
>gi|157388989 solute carrier family 25, member 36 isoform a [Homo
sapiens]
Length = 311
Score = 85.9 bits (211), Expect = 4e-17
Identities = 58/200 (29%), Positives = 97/200 (48%), Gaps = 15/200 (7%)
Query: 94 AQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQN--------QTEPRAQPGSPPPRY- 144
+Q + +H+F GC GG + A P +++K RLQ+ + + G+ R
Sbjct: 2 SQRDTLVHLFAGGC-GGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVV 60
Query: 145 -QGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSAT 203
GP+HC I +EGPR LFRG + P+ IYF Y C++ + +P S
Sbjct: 61 SPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSN-CKEKLNDVFDPDSTQ 119
Query: 204 V-LVAGGFAGIASWVAATPLDMIKSRMQMDGLRR-RVYQGMLDCMVSSIRQEGLGVFFRG 261
V +++ AG + A P+ +IK+R+Q+D R G +C+ + +GL F+RG
Sbjct: 120 VHMISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRG 179
Query: 262 VTINSARAFPVNAVTFLSYE 281
++ + A + F+ YE
Sbjct: 180 MSASYA-GISETVIHFVIYE 198
Score = 80.1 bits (196), Expect = 2e-15
Identities = 75/311 (24%), Positives = 124/311 (39%), Gaps = 50/311 (16%)
Query: 8 AGWISGALGLVLGHPFDTVKVRLQTQ--TTY-------------------RGIVDCMVKI 46
AG G +G +L P + VK RLQ+ T Y G + C+ I
Sbjct: 12 AGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVVSPGPLHCLKVI 71
Query: 47 YRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAG 106
E F+G+ + +A ++ F YSN L P S ++
Sbjct: 72 LEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVF------DPDSTQVHMISA 125
Query: 107 CTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRG 166
GF P LIK RLQ R + R G C +++ +G +G +RG
Sbjct: 126 AMAGFTAITATNPIWLIKTRLQLDARNRGE------RRMGAFECVRKVYQTDGLKGFYRG 179
Query: 167 AWALTLRDTPTVGIYFITYEGLCRQY----TPEGQNPSSATVLVAGGFAGIASWVA---- 218
A + TV I+F+ YE + ++ T +V A F G+ A
Sbjct: 180 MSASYAGISETV-IHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKT 238
Query: 219 -----ATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVN 273
A P +++++R++ +G + R + L +V ++EG G +RG+T + R P
Sbjct: 239 CATTIAYPHEVVRTRLREEGTKYRSFFQTLSLLV---QEEGYGSLYRGLTTHLVRQIPNT 295
Query: 274 AVTFLSYEYLL 284
A+ +YE ++
Sbjct: 296 AIMMATYELVV 306
Score = 57.8 bits (138), Expect = 1e-08
Identities = 44/191 (23%), Positives = 82/191 (42%), Gaps = 21/191 (10%)
Query: 7 VAGWISGALGLVLGHPFDTVKVRLQTQTTYRG-----IVDCMVKIYRHESLLGFFKGMSF 61
++ ++G + +P +K RLQ RG +C+ K+Y+ + L GF++GMS
Sbjct: 123 ISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGMSA 182
Query: 62 PIASIA--VVNSVLFGVYSNTLL----VLTATSHQERRAQPPSYMHIFLAGCTGGFLQAY 115
A I+ V++ V++ LL T + +E + ++ + LA T
Sbjct: 183 SYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCATT 242
Query: 116 CLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDT 175
P ++++ RL+ + +Y+ + + +EEG L+RG +R
Sbjct: 243 IAYPHEVVRTRLREE----------GTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQI 292
Query: 176 PTVGIYFITYE 186
P I TYE
Sbjct: 293 PNTAIMMATYE 303
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 84.0 bits (206), Expect = 1e-16
Identities = 69/293 (23%), Positives = 124/293 (42%), Gaps = 30/293 (10%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQ----------TTYRGIVDCMVKIYRHESLLGF 55
FV G ++ P D K RLQ Q YRG++ +V+I R E L
Sbjct: 9 FVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKAL 68
Query: 56 FKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAY 115
+ G++ + A ++ G Y + + R + + + G G + +
Sbjct: 69 YSGIAPAMLRQASYGTIKIGTYQSLKRLFI------ERPEDETLPINVICGILSGVISST 122
Query: 116 CLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDT 175
P D++K+R+Q Q+ G + +I+++EG RGL++G R
Sbjct: 123 IANPTDVLKIRMQAQSNTIQG---------GMIGNFMNIYQQEGTRGLWKGVSLTAQRAA 173
Query: 176 PTVGIYFITYEGLCRQYTPEG-QNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGL 234
VG+ Y+ + G + T ++ G+A +A+ P+D++++RM +
Sbjct: 174 IVVGVELPVYDITKKHLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQRV 233
Query: 235 RR----RVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 283
R Y G LDC++ + + EG ++G N R P N + F++YE L
Sbjct: 234 LRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQL 286
Score = 41.2 bits (95), Expect = 0.001
Identities = 25/86 (29%), Positives = 40/86 (46%), Gaps = 6/86 (6%)
Query: 206 VAGGFAGIASWVAATPLDMIKSRMQMDG------LRRRVYQGMLDCMVSSIRQEGLGVFF 259
V GG A I + P+D+ K+R+Q+ G + Y+GML +V R+EGL +
Sbjct: 10 VYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLKALY 69
Query: 260 RGVTINSARAFPVNAVTFLSYEYLLR 285
G+ R + +Y+ L R
Sbjct: 70 SGIAPAMLRQASYGTIKIGTYQSLKR 95
>gi|4507009 solute carrier family 25, member 14 isoform UCP5L [Homo
sapiens]
Length = 325
Score = 83.2 bits (204), Expect = 2e-16
Identities = 70/295 (23%), Positives = 127/295 (43%), Gaps = 31/295 (10%)
Query: 6 FVAGWISGALGLVLGHPFDTVKVRLQTQ----------TTYRGIVDCMVKIYRHESLLGF 55
FV G ++ + P D K RLQ Q YRG+ + +I + E +L
Sbjct: 44 FVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDARFKEIKYRGMFHALFRICKEEGVLAL 103
Query: 56 FKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAY 115
+ G++ + A ++ G+Y + + R + + + + G G + +
Sbjct: 104 YSGIAPALLRQASYGTIKIGIYQSLKRLFV------ERLEDETLLINMICGVVSGVISST 157
Query: 116 CLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGP-VHCAASIFREEGPRGLFRGAWALTLRD 174
P D++K+R+Q Q GS +QG + I+++EG RGL+RG R
Sbjct: 158 IANPTDVLKIRMQAQ-------GS---LFQGSMIGSFIDIYQQEGTRGLWRGVVPTAQRA 207
Query: 175 TPTVGIYFITYEGLCRQYTPEGQ-NPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDG 233
VG+ Y+ + G + T V+ G+A +A+ P+D++++RM
Sbjct: 208 AIVVGVELPVYDITKKHLILSGMMGDTILTHFVSSFTCGLAGALASNPVDVVRTRMMNQR 267
Query: 234 L---RRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLR 285
+Y+G +D ++ + EG ++G N R P N + F++YE L R
Sbjct: 268 AIVGHVDLYKGTVDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKR 322
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.140 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,364,533
Number of Sequences: 37866
Number of extensions: 514633
Number of successful extensions: 2609
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 1828
Number of HSP's gapped (non-prelim): 265
length of query: 288
length of database: 18,247,518
effective HSP length: 101
effective length of query: 187
effective length of database: 14,423,052
effective search space: 2697110724
effective search space used: 2697110724
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.