Search of human proteins with 116089333

Search of human proteins with 116089333

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|116089333 kelch domain containing 7A [Homo sapiens]
         (777 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|116089333 kelch domain containing 7A [Homo sapiens]               1604   0.0  
gi|206597556 kelch domain containing 7B [Homo sapiens]                299   6e-81
gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo...   287   3e-77
gi|55749726 kelch domain containing 5 [Homo sapiens]                  111   3e-24
gi|157384932 hypothetical protein LOC390594 [Homo sapiens]             92   1e-18
gi|24308181 kelch-like 9 [Homo sapiens]                                78   4e-14
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]                      72   2e-12
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]                      72   2e-12
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]                      72   2e-12
gi|158508542 kelch-like 33 [Homo sapiens]                              72   3e-12
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]         71   3e-12
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]         71   3e-12
gi|24475847 influenza virus NS1A binding protein [Homo sapiens]        71   4e-12
gi|88196794 kelch-like 35 [Homo sapiens]                               70   6e-12
gi|38194229 kelch-like 17 [Homo sapiens]                               70   7e-12
gi|45643138 kelch-like 13 [Homo sapiens]                               70   1e-11
gi|40807500 kelch-like 20 [Homo sapiens]                               68   4e-11
gi|40018614 DRE1 protein [Homo sapiens]                                66   1e-10
gi|55741643 kelch-like 14 [Homo sapiens]                               65   2e-10
gi|31542246 kelch-like 36 [Homo sapiens]                               64   7e-10
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]               64   7e-10
gi|34101268 kelch-like 8 [Homo sapiens]                                63   9e-10
gi|23397572 kelch-like 34 [Homo sapiens]                               63   1e-09
gi|166235129 kelch-like 3 [Homo sapiens]                               62   2e-09
gi|24432026 kelch-like [Homo sapiens]                                  62   3e-09
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]             61   5e-09
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]             61   5e-09
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]             61   5e-09
gi|55925608 kelch-like 21 [Homo sapiens]                               60   6e-09
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]                     60   1e-08

>gi|116089333 kelch domain containing 7A [Homo sapiens]
          Length = 777

 Score = 1604 bits (4154), Expect = 0.0
 Identities = 777/777 (100%), Positives = 777/777 (100%)

Query: 1   MFPRGAEAQDWHLDMQLTGKVVLSAAALLLVTVAYRLYKSRPAPAQRWGGNGQAEAKEEA 60
           MFPRGAEAQDWHLDMQLTGKVVLSAAALLLVTVAYRLYKSRPAPAQRWGGNGQAEAKEEA
Sbjct: 1   MFPRGAEAQDWHLDMQLTGKVVLSAAALLLVTVAYRLYKSRPAPAQRWGGNGQAEAKEEA 60

Query: 61  EGSGQPAVQEASPGVLLRGPRRRRSSKRAEAPQGCSCENPRGPYVLVTGATSTDRKPQRK 120
           EGSGQPAVQEASPGVLLRGPRRRRSSKRAEAPQGCSCENPRGPYVLVTGATSTDRKPQRK
Sbjct: 61  EGSGQPAVQEASPGVLLRGPRRRRSSKRAEAPQGCSCENPRGPYVLVTGATSTDRKPQRK 120

Query: 121 GSGEERGGQGSDSEQVPPCCPSQETRTAVGSNPDPPHFPRLGSEPKSSPAGLIAAADGSC 180
           GSGEERGGQGSDSEQVPPCCPSQETRTAVGSNPDPPHFPRLGSEPKSSPAGLIAAADGSC
Sbjct: 121 GSGEERGGQGSDSEQVPPCCPSQETRTAVGSNPDPPHFPRLGSEPKSSPAGLIAAADGSC 180

Query: 181 AGGEPSPWQDSKPREHPGLGQLEPPHCHYVAPLQGSSDMNQSWVFTRVIGVSREEAGALE 240
           AGGEPSPWQDSKPREHPGLGQLEPPHCHYVAPLQGSSDMNQSWVFTRVIGVSREEAGALE
Sbjct: 181 AGGEPSPWQDSKPREHPGLGQLEPPHCHYVAPLQGSSDMNQSWVFTRVIGVSREEAGALE 240

Query: 241 AASDVDLTLHQQEGAPNSSYTFSSIARVRMEEHFIQKAEGVEPRLKGKVYDYYVESTSQA 300
           AASDVDLTLHQQEGAPNSSYTFSSIARVRMEEHFIQKAEGVEPRLKGKVYDYYVESTSQA
Sbjct: 241 AASDVDLTLHQQEGAPNSSYTFSSIARVRMEEHFIQKAEGVEPRLKGKVYDYYVESTSQA 300

Query: 301 IFQGRLAPRTAALTEVPSPRPPPGSLGTGAASGGQAGDTKGAAERAASPQTGPWPSTRGF 360
           IFQGRLAPRTAALTEVPSPRPPPGSLGTGAASGGQAGDTKGAAERAASPQTGPWPSTRGF
Sbjct: 301 IFQGRLAPRTAALTEVPSPRPPPGSLGTGAASGGQAGDTKGAAERAASPQTGPWPSTRGF 360

Query: 361 SRKESLLQIAENPELQLQPDGFRLPAPPCPDPGALPGLGRSSREPHVQPVAGTNFFHIPL 420
           SRKESLLQIAENPELQLQPDGFRLPAPPCPDPGALPGLGRSSREPHVQPVAGTNFFHIPL
Sbjct: 361 SRKESLLQIAENPELQLQPDGFRLPAPPCPDPGALPGLGRSSREPHVQPVAGTNFFHIPL 420

Query: 421 TPASAPQVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAER 480
           TPASAPQVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAER
Sbjct: 421 TPASAPQVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIYGCLSGAER 480

Query: 481 ELILQRRLRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMPPEAVSRGCAICSLFN 540
           ELILQRRLRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMPPEAVSRGCAICSLFN
Sbjct: 481 ELILQRRLRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMPPEAVSRGCAICSLFN 540

Query: 541 YLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLN 600
           YLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLN
Sbjct: 541 YLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLN 600

Query: 601 SVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAG 660
           SVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAG
Sbjct: 601 SVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAG 660

Query: 661 PTGGSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAV 720
           PTGGSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAV
Sbjct: 661 PTGGSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAV 720

Query: 721 VDNLIYCVGRRSTLCFLADSVSPRFVPKELRSFPAPQGTLLPTVLTLPTPDLPQTRV 777
           VDNLIYCVGRRSTLCFLADSVSPRFVPKELRSFPAPQGTLLPTVLTLPTPDLPQTRV
Sbjct: 721 VDNLIYCVGRRSTLCFLADSVSPRFVPKELRSFPAPQGTLLPTVLTLPTPDLPQTRV 777


>gi|206597556 kelch domain containing 7B [Homo sapiens]
          Length = 594

 Score =  299 bits (766), Expect = 6e-81
 Identities = 200/534 (37%), Positives = 262/534 (49%), Gaps = 64/534 (11%)

Query: 304 GRLAPRTAALTEVPSPRPPPGSLGTGAASGG-----QAGDTKGAAERAASPQTGPWPSTR 358
           G+  PR++     PSP PPPG  G G          QA   +G A+  A    GP  S+ 
Sbjct: 61  GQPQPRSSETNGSPSPDPPPGLRGEGTREKSLDPLPQAAMPRGPAQPPAQRPPGPAASSS 120

Query: 359 GFS-------RKESLLQIAENPELQLQPDGFRLPAPPCPDPGALPGLGRSSREPHVQPVA 411
                     RK S  +IA + E +++P     P    P  G  P  GRS      Q  A
Sbjct: 121 ARRSQPVPQLRKRSRCEIAPSSEQEVRPAASGDPQGEAPGEGGSPA-GRSGALTEKQEEA 179

Query: 412 -----------GTNFFHIPLTPAS---------APQVRLDLGNCYEVLTLAKRQNLEALK 451
                      G      P  P+S         A + RLDLG+C +VL  A++     L 
Sbjct: 180 RKLMVFLQRPGGWGVVEGPRKPSSRALEPATAAALRRRLDLGSCLDVLAFAQQHGEPGLA 239

Query: 452 EAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRL-RGRQYLVVADVCPKEDSGG--- 507
           +  Y +MS+N L+VL  P +Y  LS A+RE IL  R  RGR  L V  V P    GG   
Sbjct: 240 QETYALMSDNLLRVLGDPCLYRRLSAADRERILSLRTGRGRAVLGVL-VLPSLYQGGRSG 298

Query: 508 -----------------------LCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFV 544
                                  L  ++  ++ WRPL ++P EA  RGC +C++ NYLF+
Sbjct: 299 LPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFL 358

Query: 545 VSGCQGPGHQP--SSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLNSV 602
             G +G G +   S+ VFCYNPLT IWS+V P+ QAR   +LVALDG LYAIGGECL S+
Sbjct: 359 AGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGECLYSM 418

Query: 603 ERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAGPT 662
           E YDPR D W    PLP+ TF +AH A     +I+VTGG L + L R+S  +  W   P 
Sbjct: 419 ECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRLLRYSPVKDAWDECPY 478

Query: 663 GGSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAVVD 722
             S  R++++VA+ GFLYRFDL R +G AV R +  T  W   A+   P P    C  + 
Sbjct: 479 SASHRRSSDIVALGGFLYRFDLLRGVGAAVMRYNTVTGSWSRAASLPLPAPAPLHCTTLG 538

Query: 723 NLIYCVGRRSTLCFLADSVSPRFVPKELRSFP-APQGTLLPTVLTLPTPDLPQT 775
           N IYC+  + T  F     + +F  KEL+ FP    G L P +LTLP  D  QT
Sbjct: 539 NTIYCLNPQVTATFTVSGGTAQFQAKELQPFPLGSTGVLSPFILTLPPEDRLQT 592


>gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo
           sapiens]
          Length = 623

 Score =  287 bits (734), Expect = 3e-77
 Identities = 166/368 (45%), Positives = 212/368 (57%), Gaps = 43/368 (11%)

Query: 410 VAGTNFFHIP-----LTPASAPQVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQ 464
           VAG     +P      T A  PQ  L L NCYEVL+ AKRQ L  L++AAY  MS++YL+
Sbjct: 208 VAGARRLQLPGAAQRATDAVGPQ--LSLANCYEVLSAAKRQRLNELRDAAYCFMSDHYLE 265

Query: 465 VLRSPDIYGCLSGAERELILQRRLR-GRQYLVVADVCPKEDSGG---------------- 507
           VLR P ++G LSGAER+L+L+RRLR GR +L+ A + P  +  G                
Sbjct: 266 VLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAALGPAGERAGSRPQSPSGDADARGDA 325

Query: 508 -LCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGH----QPSSRVFCY 562
            + C+      WR L R+P  A +RGC +C L+NYLFV  G    G     +PS +VFCY
Sbjct: 326 AVYCFHAAAGEWRELTRLPEGAPARGCGLCVLYNYLFVAGGVAPAGPDGRARPSDQVFCY 385

Query: 563 NPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLNSVERYDPRLDRWDFAPPLPSDT 622
           NP T  WS V PL QAR   RL+ALDGHLYA+GGECL SVERYDPR DRW    PLP   
Sbjct: 386 NPATDSWSAVRPLRQARSQLRLLALDGHLYAVGGECLLSVERYDPRADRWAPVAPLPRGA 445

Query: 623 FALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRF 682
           FA+AH AT    EI+V+GGSL + L ++  +   W   P   S++R+A+MVA++GF+YRF
Sbjct: 446 FAVAHEATTCHGEIYVSGGSLFYRLLKYDPRRDEWQECPCSSSRERSADMVALDGFIYRF 505

Query: 683 DLNRS---------LGIAVYRCSASTRLWYEC-ATYRTPYP----DAFQCAVVDNLIYCV 728
           DL+ S          G++V R     + W  C A  R P        F+CA +D  IYCV
Sbjct: 506 DLSGSRGEAQAAGPSGVSVSRYHCLAKQWSPCVAPLRLPGGPTGLQPFRCAALDGAIYCV 565

Query: 729 GRRSTLCF 736
            R  T  F
Sbjct: 566 SRAGTWRF 573


>gi|55749726 kelch domain containing 5 [Homo sapiens]
          Length = 505

 Score =  111 bits (277), Expect = 3e-24
 Identities = 115/386 (29%), Positives = 170/386 (44%), Gaps = 53/386 (13%)

Query: 427 QVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENYLQVLRSPDIY--GCLSGAERELIL 484
           QVRL+  NC E+  LA+   L  L+EA  + M  ++ +VL  P  +  G    A  ++ L
Sbjct: 124 QVRLN--NCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVSL 181

Query: 485 QRRLR-----GRQYLVV------ADVCPKEDSG---GLCCYDDEQDVWRPLAR-MPPEAV 529
           ++RLR     G   LV         + P    G    +  Y++  + W PLA  +PP+ V
Sbjct: 182 KQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLRYEEMTERWFPLANNLPPDLV 241

Query: 530 S-RGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALD 588
           + RG     L NYLF+V G +    Q  S    YNP T  W +V  +NQ R + +LVA++
Sbjct: 242 NVRGYGSAILDNYLFIVGGYRITS-QEISAAHSYNPSTNEWLQVASMNQKRSNFKLVAVN 300

Query: 589 GHLYAIGGECLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAK-EIFVTGG----SL 643
             LYAIGG+ +++VE Y+P  D W+F  PLP+    LA  +    K +I+V GG      
Sbjct: 301 SKLYAIGGQAVSNVECYNPEQDAWNFVAPLPN---PLAEFSACECKGKIYVIGGYTTRDR 357

Query: 644 RFLLFRFSAQEQRWWAGPTGGSKDRTAEMVA-------VNGFLYRFDLNRSLG-----IA 691
              + ++      W    T     R  +MV+       V G L+    NR        + 
Sbjct: 358 NMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHELGPNRRSSQSEDMLT 417

Query: 692 VYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVGRRSTLCFLADSVSPRFVPK--- 748
           V   +  TR W       +       CA+ ++ IY + R  T   L+ S+  R   K   
Sbjct: 418 VQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVT---LSTSLEHRVFLKYNI 474

Query: 749 ------ELRSFPAPQGTLLPTVLTLP 768
                   R FPA    LL + L LP
Sbjct: 475 FSDSWEAFRRFPAFGHNLLVSSLYLP 500


>gi|157384932 hypothetical protein LOC390594 [Homo sapiens]
          Length = 458

 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 55/141 (39%), Positives = 71/141 (50%), Gaps = 9/141 (6%)

Query: 488 LRGRQYLVVADVCPK----EDSGGLCCY-DDEQDVWRPLARMPPEAVSRGCAICSLFNYL 542
           LR   Y  V+   P     ED+    CY D+E+D WR LA +P EA +    + +L N L
Sbjct: 152 LRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKL 211

Query: 543 FVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGEC---- 598
           ++V G +G   +     FCY+P  G W E    +Q R    L   DG LYAIGGE     
Sbjct: 212 YIVGGVRGASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTP 271

Query: 599 LNSVERYDPRLDRWDFAPPLP 619
           ++SVERYDP    W F   LP
Sbjct: 272 ISSVERYDPAAGCWSFVADLP 292


>gi|24308181 kelch-like 9 [Homo sapiens]
          Length = 617

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 91/328 (27%), Positives = 131/328 (39%), Gaps = 39/328 (11%)

Query: 422 PASAPQVRLDLGNCYEVLTLAKRQN--LEALKEAA-YKVMSENYLQVLRSPDIYGCLSGA 478
           P   PQ   DL N  + +   +  N  +  L EA+ Y++M   Y+Q +   D     S +
Sbjct: 243 PLMTPQ---DLINYVQTVDFMRTDNTCVNLLLEASNYQMMP--YMQPVMQSDRTAIRSDS 297

Query: 479 ERELILQRRLRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMPPEAVSRGCAICSL 538
              + L   LR  Q LVV+    KE    L  YD+    WR LA M       G A+   
Sbjct: 298 THLVTLGGVLR--QQLVVS----KE----LRMYDERAQEWRSLAPMDAPRYQHGIAVIG- 346

Query: 539 FNYLFVVSGCQG---PGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIG 595
            N+L+VV G       G      VF ++P    W +V  LN+ R    L AL GHLYA+G
Sbjct: 347 -NFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVG 405

Query: 596 GEC----LNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG----SLRFLL 647
           G      L +VE Y+PR++ W +   +    +   H  TV    ++++GG    + +  L
Sbjct: 406 GRSAAGELATVECYNPRMNEWSYVAKMSEPHY--GHAGTVYGGLMYISGGITHDTFQNEL 463

Query: 648 FRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECAT 707
             F     +W       +      M  V   LY    N   G + Y    S   +     
Sbjct: 464 MCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLD 523

Query: 708 YRTPYPDAFQ------CAVVDNLIYCVG 729
             TP     +       AV +N IY VG
Sbjct: 524 QWTPIAAMLRGQSDVGVAVFENKIYVVG 551



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 30/122 (24%), Positives = 51/122 (41%), Gaps = 13/122 (10%)

Query: 508 LCCYDDEQDVWRPLARMPPEAVSRGC-AICSLFNYLFVVSGCQGPGHQPSSRVFC---YN 563
           L C+D + D W   A   P    RG   +C++ + L+V+ G    G      V     Y+
Sbjct: 463 LMCFDPDTDKWMQKA---PMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYS 519

Query: 564 PLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLNS------VERYDPRLDRWDFAPP 617
           P    W+ +  + + +    +   +  +Y +GG   N+      V++YDP  D W     
Sbjct: 520 PTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFD 579

Query: 618 LP 619
           LP
Sbjct: 580 LP 581


>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
          Length = 709

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 64/237 (27%), Positives = 102/237 (43%), Gaps = 27/237 (11%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD   ++W P+A M    +  G A+  L + L+VV G  G   +  + V CYNP T  WS
Sbjct: 441 YDLRTNMWTPVANMNGRRLQFGVAV--LDDKLYVVGGRDGL--KTLNTVECYNPKTKTWS 496

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPL--PSDTFA 624
            + P++  R    +  L+G +YA+GG      LN+VER+DP+  +W+F   +  P  T  
Sbjct: 497 VMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 556

Query: 625 LAHTATVRAKEIFVTGG----SLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLY 680
           +A    V + +++  GG    S    +  F     +W        +     +   NG LY
Sbjct: 557 VA----VLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 612

Query: 681 RF--------DLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVG 729
                     +L   L   V R    T +W   A+      DA    ++ + +Y VG
Sbjct: 613 AIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSIS-RDAVGVCLLGDKLYAVG 668



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 10/117 (8%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSR----VFCYNPL 565
           C+D   + W   A+M       G  + +    L+ + G   P    +SR    V  Y+P 
Sbjct: 581 CFDPHTNKWTLCAQMSKRR--GGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPK 638

Query: 566 TGIWSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPL 618
           T +W+ V  ++ +R    +  L   LYA+GG      LN+VE YDP+ + W    PL
Sbjct: 639 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 695


>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
          Length = 694

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 64/237 (27%), Positives = 102/237 (43%), Gaps = 27/237 (11%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD   ++W P+A M    +  G A+  L + L+VV G  G   +  + V CYNP T  WS
Sbjct: 426 YDLRTNMWTPVANMNGRRLQFGVAV--LDDKLYVVGGRDGL--KTLNTVECYNPKTKTWS 481

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPL--PSDTFA 624
            + P++  R    +  L+G +YA+GG      LN+VER+DP+  +W+F   +  P  T  
Sbjct: 482 VMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 541

Query: 625 LAHTATVRAKEIFVTGG----SLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLY 680
           +A    V + +++  GG    S    +  F     +W        +     +   NG LY
Sbjct: 542 VA----VLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 597

Query: 681 RF--------DLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVG 729
                     +L   L   V R    T +W   A+      DA    ++ + +Y VG
Sbjct: 598 AIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSIS-RDAVGVCLLGDKLYAVG 653



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 10/117 (8%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSR----VFCYNPL 565
           C+D   + W   A+M       G  + +    L+ + G   P    +SR    V  Y+P 
Sbjct: 566 CFDPHTNKWTLCAQMSKRR--GGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPK 623

Query: 566 TGIWSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPL 618
           T +W+ V  ++ +R    +  L   LYA+GG      LN+VE YDP+ + W    PL
Sbjct: 624 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 680


>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
          Length = 755

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 64/237 (27%), Positives = 102/237 (43%), Gaps = 27/237 (11%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD   ++W P+A M    +  G A+  L + L+VV G  G   +  + V CYNP T  WS
Sbjct: 487 YDLRTNMWTPVANMNGRRLQFGVAV--LDDKLYVVGGRDGL--KTLNTVECYNPKTKTWS 542

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPL--PSDTFA 624
            + P++  R    +  L+G +YA+GG      LN+VER+DP+  +W+F   +  P  T  
Sbjct: 543 VMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVG 602

Query: 625 LAHTATVRAKEIFVTGG----SLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLY 680
           +A    V + +++  GG    S    +  F     +W        +     +   NG LY
Sbjct: 603 VA----VLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLY 658

Query: 681 RF--------DLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVG 729
                     +L   L   V R    T +W   A+      DA    ++ + +Y VG
Sbjct: 659 AIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSIS-RDAVGVCLLGDKLYAVG 714



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 10/117 (8%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSR----VFCYNPL 565
           C+D   + W   A+M       G  + +    L+ + G   P    +SR    V  Y+P 
Sbjct: 627 CFDPHTNKWTLCAQMSKRR--GGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPK 684

Query: 566 TGIWSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPL 618
           T +W+ V  ++ +R    +  L   LYA+GG      LN+VE YDP+ + W    PL
Sbjct: 685 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 741


>gi|158508542 kelch-like 33 [Homo sapiens]
          Length = 453

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 47/129 (36%), Positives = 65/129 (50%), Gaps = 7/129 (5%)

Query: 518 WRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPS-SRVFCYNPLTGIWSEVCPLN 576
           W  L  +P     R  A     + L+V  G     H  + +    + P    W E+ PL+
Sbjct: 170 WGQLPALPAPGRFRHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWEEMAPLS 229

Query: 577 QARPHCRLVALDGHLYAIGGE----CLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVR 632
           QAR    LVALDG LYA+GG      L+SVE Y+P L+ W  AP LP+  F  AH A + 
Sbjct: 230 QARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAPCF--AHAAAIL 287

Query: 633 AKEIFVTGG 641
             +++V+GG
Sbjct: 288 EGQLYVSGG 296



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 45/135 (33%), Positives = 59/135 (43%), Gaps = 8/135 (5%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           Y+ E +VWRP   +P    +   AI  L   L+V  GC G G   +S +     L    +
Sbjct: 262 YNPELNVWRPAPALPAPCFAHAAAI--LEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGT 319

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLPSDTFALA 626
            + P+   R    + AL G LY  GG    E L S E Y+ R D W    PLPS     A
Sbjct: 320 FLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPSPHVGAA 379

Query: 627 HTATVRAKEIFVTGG 641
             + V   E+ V GG
Sbjct: 380 --SAVLQGELLVLGG 392


>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 41/115 (35%), Positives = 58/115 (50%), Gaps = 10/115 (8%)

Query: 511 YDDEQDVWRPLARMP-PEAVSRGCAICSLFNYLFVVSGCQGP--GHQPSSRVFCYNPLTG 567
           Y+     W  LA +  P +   GC +  L   L+ V G      G+  SS + CYNP+T 
Sbjct: 345 YNPSDGTWLRLADLQVPRSGLAGCVVGGL---LYAVGGRNNSPDGNTDSSALDCYNPMTN 401

Query: 568 IWSEVCPLNQARPHCRLVALDGHLYAIGGE--CL--NSVERYDPRLDRWDFAPPL 618
            WS   P++  R    +  +DGH+YA+GG   C+  NSVERY+P  D W    P+
Sbjct: 402 QWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM 456



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 44/135 (32%), Positives = 59/135 (43%), Gaps = 10/135 (7%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           Y+ E+D W  +A M    +  G A+  L   L+ V G  G     S+   CY P    W 
Sbjct: 443 YEPERDEWHLVAPMLTRRIGVGVAV--LNRLLYAVGGFDGTNRLNSAE--CYYPERNEWR 498

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLPSDTFALA 626
            +  +N  R    +  L   +YA GG    + LNSVERYD   + W F  P+     AL 
Sbjct: 499 MITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALG 558

Query: 627 HTATVRAKEIFVTGG 641
              TV    I+V GG
Sbjct: 559 --ITVHQGRIYVLGG 571



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 33/107 (30%), Positives = 47/107 (43%), Gaps = 8/107 (7%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIW 569
           CY  E++ WR +  M    +  G  +C L N ++   G  G     S  V  Y+  T  W
Sbjct: 489 CYYPERNEWRMITAM--NTIRSGAGVCVLHNCIYAAGGYDGQDQLNS--VERYDVETETW 544

Query: 570 SEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRW 612
           + V P+   R    +    G +Y +GG      L+SVE YDP  D W
Sbjct: 545 TFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 27/114 (23%), Positives = 43/114 (37%), Gaps = 18/114 (15%)

Query: 513 DEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEV 572
           +E  + +P   MP  A   G  I +   Y            Q  S +  YNP  G W  +
Sbjct: 306 EELTLHKPTQVMPCRAPKVGRLIYTAGGYF----------RQSLSYLEAYNPSDGTWLRL 355

Query: 573 CPLNQARPHCRLVALDGHLYAIGGE--------CLNSVERYDPRLDRWDFAPPL 618
             L   R       + G LYA+GG           ++++ Y+P  ++W    P+
Sbjct: 356 ADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPM 409



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 4/69 (5%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD E + W  +A M     + G  +      ++V+ G  G  H     V CY+P T  WS
Sbjct: 537 YDVETETWTFVAPMKHRRSALGITVHQ--GRIYVLGGYDG--HTFLDSVECYDPDTDTWS 592

Query: 571 EVCPLNQAR 579
           EV  +   R
Sbjct: 593 EVTRMTSGR 601


>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
          Length = 624

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 41/115 (35%), Positives = 58/115 (50%), Gaps = 10/115 (8%)

Query: 511 YDDEQDVWRPLARMP-PEAVSRGCAICSLFNYLFVVSGCQGP--GHQPSSRVFCYNPLTG 567
           Y+     W  LA +  P +   GC +  L   L+ V G      G+  SS + CYNP+T 
Sbjct: 345 YNPSDGTWLRLADLQVPRSGLAGCVVGGL---LYAVGGRNNSPDGNTDSSALDCYNPMTN 401

Query: 568 IWSEVCPLNQARPHCRLVALDGHLYAIGGE--CL--NSVERYDPRLDRWDFAPPL 618
            WS   P++  R    +  +DGH+YA+GG   C+  NSVERY+P  D W    P+
Sbjct: 402 QWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM 456



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 44/135 (32%), Positives = 59/135 (43%), Gaps = 10/135 (7%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           Y+ E+D W  +A M    +  G A+  L   L+ V G  G     S+   CY P    W 
Sbjct: 443 YEPERDEWHLVAPMLTRRIGVGVAV--LNRLLYAVGGFDGTNRLNSAE--CYYPERNEWR 498

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLPSDTFALA 626
            +  +N  R    +  L   +YA GG    + LNSVERYD   + W F  P+     AL 
Sbjct: 499 MITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALG 558

Query: 627 HTATVRAKEIFVTGG 641
              TV    I+V GG
Sbjct: 559 --ITVHQGRIYVLGG 571



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 33/107 (30%), Positives = 47/107 (43%), Gaps = 8/107 (7%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIW 569
           CY  E++ WR +  M    +  G  +C L N ++   G  G     S  V  Y+  T  W
Sbjct: 489 CYYPERNEWRMITAM--NTIRSGAGVCVLHNCIYAAGGYDGQDQLNS--VERYDVETETW 544

Query: 570 SEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRW 612
           + V P+   R    +    G +Y +GG      L+SVE YDP  D W
Sbjct: 545 TFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 27/114 (23%), Positives = 43/114 (37%), Gaps = 18/114 (15%)

Query: 513 DEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEV 572
           +E  + +P   MP  A   G  I +   Y            Q  S +  YNP  G W  +
Sbjct: 306 EELTLHKPTQVMPCRAPKVGRLIYTAGGYF----------RQSLSYLEAYNPSDGTWLRL 355

Query: 573 CPLNQARPHCRLVALDGHLYAIGGE--------CLNSVERYDPRLDRWDFAPPL 618
             L   R       + G LYA+GG           ++++ Y+P  ++W    P+
Sbjct: 356 ADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPM 409



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 21/69 (30%), Positives = 30/69 (43%), Gaps = 4/69 (5%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD E + W  +A M     + G  +      ++V+ G  G  H     V CY+P T  WS
Sbjct: 537 YDVETETWTFVAPMKHRRSALGITVHQ--GRIYVLGGYDG--HTFLDSVECYDPDTDTWS 592

Query: 571 EVCPLNQAR 579
           EV  +   R
Sbjct: 593 EVTRMTSGR 601


>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
          Length = 642

 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 46/158 (29%), Positives = 71/158 (44%), Gaps = 8/158 (5%)

Query: 488 LRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSG 547
           L G+ Y+V       +D      YD   D W P+  +     + G  +C+L   L++V G
Sbjct: 413 LMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAG--VCALNGKLYIVGG 470

Query: 548 CQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVE 603
               G +       ++P+T +W+   PLN  R    +  L G+LY IGG     CLN+VE
Sbjct: 471 SDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVE 530

Query: 604 RYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG 641
           RY+P  + W    P+  +         V   ++FV GG
Sbjct: 531 RYNPENNTWTLIAPM--NVARRGAGVAVLNGKLFVCGG 566



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 29/89 (32%), Positives = 43/89 (48%), Gaps = 7/89 (7%)

Query: 559 VFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG-----ECLNSVERYDPRLDRWD 613
           V CYNP T  WS + P+   R   ++  L G LY +GG     + L+  E YD  +D W 
Sbjct: 385 VECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWI 444

Query: 614 FAPPLPSDTFALAHTATVRAKEIFVTGGS 642
             P L ++    A    +  K +++ GGS
Sbjct: 445 PVPELRTNR-CNAGVCALNGK-LYIVGGS 471



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 47/177 (26%), Positives = 67/177 (37%), Gaps = 19/177 (10%)

Query: 574 PLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPL--PSDTFALAH 627
           P+  AR       ++G L A GG    ECL +VE Y+P  D W F  P+  P   F +A 
Sbjct: 353 PMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYNPHTDHWSFLAPMRTPRARFQMA- 411

Query: 628 TATVRAKEIFVTGGSLRF-----LLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRF 682
              V   +++V GGS            + +    W   P   +    A + A+NG LY  
Sbjct: 412 ---VLMGQLYVVGGSNGHSDDLSCGEMYDSNIDDWIPVPELRTNRCNAGVCALNGKLYIV 468

Query: 683 DLNRSLG-IAVYRCSA---STRLWYECATYRTPYPDAFQCAVVDNLIYCVGRRSTLC 735
             +   G   +  C      T+LW  CA        +  C +   L    G  S  C
Sbjct: 469 GGSDPYGQKGLKNCDVFDPVTKLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNC 525



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 30/106 (28%), Positives = 45/106 (42%), Gaps = 8/106 (7%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           Y+ E + W  +A  P     RG  +  L   LFV  G  G      S V  Y+P    W 
Sbjct: 532 YNPENNTWTLIA--PMNVARRGAGVAVLNGKLFVCGGFDGS--HAISCVEMYDPTRNEWK 587

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRW 612
            +  +   R +  +  +   +YA+GG    E LN+VE Y+   + W
Sbjct: 588 MMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEW 633


>gi|88196794 kelch-like 35 [Homo sapiens]
          Length = 363

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 64/230 (27%), Positives = 102/230 (44%), Gaps = 21/230 (9%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           Y  E   W PL  +P    S   A C+L N ++V SG    GH  S  V+ ++     W 
Sbjct: 102 YHPESQRWTPLPSLPGYTRSEFAA-CALRNDVYV-SG----GHINSHDVWMFSSHLHTWI 155

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLPSDTFALA 626
           +V  L++ R   ++  + G L+A+GG      L+SVERYDP  + W  A PLP    + A
Sbjct: 156 KVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSSAA 215

Query: 627 HTATVRAKEIFVTGGSLR-----FLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYR 681
             +   A ++FV GG+ +       +  F  +E RW          R  E V++   +Y 
Sbjct: 216 VASC--AGKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIY- 272

Query: 682 FDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVGRR 731
             +   L   ++     T +W E A   +P  ++    V D  ++ +G R
Sbjct: 273 --VMGGLMSKIFTYDPGTDVWGEAAVLPSPV-ESCGVTVCDGKVHILGGR 319



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 30/114 (26%), Positives = 49/114 (42%), Gaps = 14/114 (12%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIW 569
           C+D ++D W    R P     R     SL + ++V+ G         S++F Y+P T +W
Sbjct: 241 CFDPKEDRWS--LRSPAPFSQRCLEAVSLEDTIYVMGGLM-------SKIFTYDPGTDVW 291

Query: 570 SEVCPLNQARPHCRLVALDGHLYAIG-----GECLNSVERYDPRLDRWDFAPPL 618
            E   L      C +   DG ++ +G     GE  + V  +DP   + +  P L
Sbjct: 292 GEAAVLPSPVESCGVTVCDGKVHILGGRDDRGESTDKVFTFDPSSGQVEVQPSL 345


>gi|38194229 kelch-like 17 [Homo sapiens]
          Length = 642

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 42/106 (39%), Positives = 57/106 (53%), Gaps = 8/106 (7%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           Y+ + +VW P+A M     S G A+  L   L+V  G  G     S  V  Y+P  G W 
Sbjct: 503 YEPQVNVWSPVASMLSRRSSAGVAV--LEGALYVAGGNDGTSCLNS--VERYSPKAGAWE 558

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRW 612
            V P+N  R    LVA+DG LYA+GG      LNS+E+Y+PR ++W
Sbjct: 559 SVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW 604



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 50/179 (27%), Positives = 84/179 (46%), Gaps = 16/179 (8%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGC-AICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIW 569
           YD   + W+P   M      R C  + +L   L+   G  G     S+    Y+PLTG W
Sbjct: 409 YDPVTNTWQPEVSM---GTRRSCLGVAALHGLLYSAGGYDGASCLNSAER--YDPLTGTW 463

Query: 570 SEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLPSDTFAL 625
           + V  ++  R + R+  LDG+LYA+GG      L +VE+Y+P+++ W     + S   + 
Sbjct: 464 TSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSA 523

Query: 626 AHTATVRAKEIFVTGG----SLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLY 680
                V    ++V GG    S    + R+S +   W +      +  T ++VA++G+LY
Sbjct: 524 G--VAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLY 580



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 36/106 (33%), Positives = 46/106 (43%), Gaps = 8/106 (7%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD   D W  +A M       G A  ++ N L+ V G  G     +  V  Y+P+T  W 
Sbjct: 362 YDTRTDRWHVVASMSTRRARVGVA--AVGNRLYAVGGYDGTSDLAT--VESYDPVTNTWQ 417

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRW 612
               +   R    + AL G LY+ GG     CLNS ERYDP    W
Sbjct: 418 PEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTW 463


>gi|45643138 kelch-like 13 [Homo sapiens]
          Length = 655

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 71/256 (27%), Positives = 102/256 (39%), Gaps = 29/256 (11%)

Query: 491 RQYLVVADVCPKEDSGGLCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQG 550
           RQ LVV+    KE    L  YD++   W+ LA M       G A+    N+L+VV G   
Sbjct: 350 RQQLVVS----KE----LRMYDEKAHEWKSLAPMDAPRYQHGIAVIG--NFLYVVGGQSN 399

Query: 551 ---PGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGEC----LNSVE 603
               G      VF ++P    W +V  LN+ R    L AL G+LYA+GG      L +VE
Sbjct: 400 YDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVE 459

Query: 604 RYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG----SLRFLLFRFSAQEQRWWA 659
            Y+PR + W +   +    +   H  TV    ++++GG    + +  L  F     +W  
Sbjct: 460 CYNPRTNEWTYVAKMSEPHY--GHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQ 517

Query: 660 GPTGGSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQ-- 717
                +      M  V   LY    N   G + Y    S   +       TP     +  
Sbjct: 518 KAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQ 577

Query: 718 ----CAVVDNLIYCVG 729
                AV +N IY VG
Sbjct: 578 SDVGVAVFENKIYVVG 593



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 28/121 (23%), Positives = 51/121 (42%), Gaps = 11/121 (9%)

Query: 508 LCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFC---YNP 564
           L C+D + D W  + + P   V     +C++   L+V+ G    G      V     Y+P
Sbjct: 505 LMCFDPDTDKW--IQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSP 562

Query: 565 LTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLNS------VERYDPRLDRWDFAPPL 618
           +   W+ +  + + +    +   +  +Y +GG   N+      V++YDP  D W     L
Sbjct: 563 ILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHKVFDL 622

Query: 619 P 619
           P
Sbjct: 623 P 623



 Score = 34.3 bits (77), Expect = 0.45
 Identities = 24/108 (22%), Positives = 44/108 (40%), Gaps = 9/108 (8%)

Query: 514 EQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVC 573
           E   ++ +  M P   S   AI S   +L  + G        S  +  Y+     W  + 
Sbjct: 314 EASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA 373

Query: 574 PLNQARPHCRLVALDGHLYAIGGE---------CLNSVERYDPRLDRW 612
           P++  R    +  +   LY +GG+          +++V R+DPR ++W
Sbjct: 374 PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421


>gi|40807500 kelch-like 20 [Homo sapiens]
          Length = 609

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 58/195 (29%), Positives = 87/195 (44%), Gaps = 22/195 (11%)

Query: 479 ERELILQRRLRGRQYLVVADV-------CPKEDSGGLCCYDDEQDVWRPLARMPPEAVSR 531
           ER L+   R R R+ +   +V       C  +    +  YD + + WR +A M       
Sbjct: 299 ERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGV 358

Query: 532 GCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS-EVCPLNQARPHCRLVALDGH 590
           G ++  L + L+ V G  G  +  S  V  Y+P T  WS +V P +  R    +  L G 
Sbjct: 359 GVSV--LDDLLYAVGGHDGSSYLNS--VERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGF 414

Query: 591 LYAIGGE----CLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG----S 642
           LYA+GG+    CLN VERYDP+ ++W     +   T  L     V    ++  GG    S
Sbjct: 415 LYAVGGQDGVSCLNIVERYDPKENKWTRVASM--STRRLGVAVAVLGGFLYAVGGSDGTS 472

Query: 643 LRFLLFRFSAQEQRW 657
               + R++ QE RW
Sbjct: 473 PLNTVERYNPQENRW 487



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 62/217 (28%), Positives = 93/217 (42%), Gaps = 20/217 (9%)

Query: 542 LFVVSG-CQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGE--- 597
           LF V G C G       R   Y+P T  W  V  +++ R    +  LD  LYA+GG    
Sbjct: 320 LFAVGGWCSGDAISSVER---YDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGS 376

Query: 598 -CLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG----SLRFLLFRFSA 652
             LNSVERYDP+ ++W  +   P+ T   +    V    ++  GG    S   ++ R+  
Sbjct: 377 SYLNSVERYDPKTNQWS-SDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDP 435

Query: 653 QEQRWWAGPTGGSKDRTAEMVAVNGFLYRF---DLNRSLGIAVYRCSASTRLWYECATYR 709
           +E +W    +  ++     +  + GFLY     D    L   V R +     W+  A   
Sbjct: 436 KENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLN-TVERYNPQENRWHTIAPMG 494

Query: 710 TPYPDAFQCAVVDNLIYCVGRR--STLCFLADSVSPR 744
           T       CAV  ++IY VG R  +T    A+  +PR
Sbjct: 495 TRRKH-LGCAVYQDMIYAVGGRDDTTELSSAERYNPR 530



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 33/106 (31%), Positives = 50/106 (47%), Gaps = 8/106 (7%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD +++ W  +A M    +  G A+  L  +L+ V G  G    P + V  YNP    W 
Sbjct: 433 YDPKENKWTRVASMSTRRL--GVAVAVLGGFLYAVGGSDGTS--PLNTVERYNPQENRWH 488

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGGEC----LNSVERYDPRLDRW 612
            + P+   R H         +YA+GG      L+S ERY+PR ++W
Sbjct: 489 TIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQW 534



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 32/112 (28%), Positives = 49/112 (43%), Gaps = 7/112 (6%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD + + W      P         +  L  +L+ V G  G      + V  Y+P    W+
Sbjct: 385 YDPKTNQWSSDVA-PTSTCRTSVGVAVLGGFLYAVGGQDGVSCL--NIVERYDPKENKWT 441

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGGEC----LNSVERYDPRLDRWDFAPPL 618
            V  ++  R    +  L G LYA+GG      LN+VERY+P+ +RW    P+
Sbjct: 442 RVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPM 493



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 29/106 (27%), Positives = 47/106 (44%), Gaps = 8/106 (7%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           Y+ +++ W  +A M       GCA+    + ++ V G        S+    YNP T  WS
Sbjct: 480 YNPQENRWHTIAPMGTRRKHLGCAVYQ--DMIYAVGGRDDTTELSSAER--YNPRTNQWS 535

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRW 612
            V  +   R    L  ++G L A+GG      L ++E +DP  + W
Sbjct: 536 PVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 581


>gi|40018614 DRE1 protein [Homo sapiens]
          Length = 600

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 63/195 (32%), Positives = 87/195 (44%), Gaps = 26/195 (13%)

Query: 465 VLRSPDIYGCLSGAERELIL----------QRRLRG-RQYLVVADVCPKEDSGGLC---C 510
           +  SP+ Y  L  A R  IL           RR  G  + +VV   C +     L    C
Sbjct: 275 IQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTEC 334

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD     W+ LA++P E      A+C+L N + +VSG    G   S  V+ YN    IW 
Sbjct: 335 YDPVTGEWKSLAKLP-EFTKSEYAVCALRNDI-LVSG----GRINSRDVWIYNSQLNIWI 388

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLPSDTFALA 626
            V  LN+ R   ++  L G +Y +GG      L+SVE YD   +RW    PL     + A
Sbjct: 389 RVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPA 448

Query: 627 HTATVRAKEIFVTGG 641
            T+ V   ++FV GG
Sbjct: 449 VTSCV--GKLFVIGG 461



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 50/202 (24%), Positives = 77/202 (38%), Gaps = 17/202 (8%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           Y+ + ++W  +A +         A+  L   ++VV G  G     S  V CY+  +  W+
Sbjct: 380 YNSQLNIWIRVASLNKGRWRHKMAV--LLGKVYVVGGYDGQNRLSS--VECYDSFSNRWT 435

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG-----ECLNSVERYDPRLDRWDFAPPLPSDTFAL 625
           EV PL +A     + +  G L+ IGG      C + V+ YDP  + W     +P    A 
Sbjct: 436 EVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIP---IAK 492

Query: 626 AHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRFDLN 685
                V    +    G L   ++ +   E  W       S+     M   NG +Y     
Sbjct: 493 RCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGR 552

Query: 686 RSLGIAVYRCSASTRLWYECAT 707
           R  G A       T L Y+ AT
Sbjct: 553 RENGEA-----TDTILCYDPAT 569



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 18/75 (24%), Positives = 36/75 (48%), Gaps = 7/75 (9%)

Query: 505 SGGLC----CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVF 560
           +GGL     CYD  +D W  +        + G ++C+    ++++ G +  G + +  + 
Sbjct: 507 AGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCN--GKIYILGGRRENG-EATDTIL 563

Query: 561 CYNPLTGIWSEVCPL 575
           CY+P T I + V  +
Sbjct: 564 CYDPATSIITGVAAM 578


>gi|55741643 kelch-like 14 [Homo sapiens]
          Length = 628

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 64/252 (25%), Positives = 98/252 (38%), Gaps = 30/252 (11%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSG---CQGPGHQPSSRVFCYNPLTG 567
           YDDE+  W+ L  MP  +      +  + N+LFV+ G       G   ++ V  Y+P   
Sbjct: 345 YDDEKKTWKILTIMPYNSAHH--CVVEVENFLFVLGGEDQWNPNGKHSTNFVSRYDPRFN 402

Query: 568 IWSEVCPLNQARPHCRLVALDGHLYAIGGE----CLNSVERYDPRLDRWDFAPPLPSDTF 623
            W ++ P+ + R       LD HLY IGG      L+SVE Y+   + W +   LP    
Sbjct: 403 SWIQLPPMQERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPL- 461

Query: 624 ALAHTATVRAKEIFVTGGSLRF----LLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFL 679
             AH   V   +I+++GG         L+ +      W       +K     +  +N  L
Sbjct: 462 -AAHAGAVHNGKIYISGGVHNGEYVPWLYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRL 520

Query: 680 YRFDLNRSLG-----IAVYRC-SASTRLWYECATYRTPYPDAFQCAVVDNLIYCVG---- 729
           Y    N   G     + +  C       W    T          CAV+D+ IY VG    
Sbjct: 521 YAIGGNHLKGFSHLDVMLVECYDPKGDQWNILQTPILEGRSGPGCAVLDDSIYLVGGYSW 580

Query: 730 -----RRSTLCF 736
                + ST+C+
Sbjct: 581 SMGAYKSSTICY 592



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 30/112 (26%), Positives = 54/112 (48%), Gaps = 12/112 (10%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIW 569
           CY+ E + WR ++ +P    +   A+ +    +++  G     + P   ++CY+P+  +W
Sbjct: 443 CYNLETNEWRYVSSLPQPLAAHAGAVHN--GKIYISGGVHNGEYVPW--LYCYDPVMDVW 498

Query: 570 SEVCPLNQARPHCRLVALDGHLYAIGGECLNS--------VERYDPRLDRWD 613
           +    +N  R    L  ++  LYAIGG  L          VE YDP+ D+W+
Sbjct: 499 ARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGDQWN 550



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 35/112 (31%), Positives = 49/112 (43%), Gaps = 16/112 (14%)

Query: 542 LFVVSGCQ-GPGHQPSSRVFCYNPLTGIWS--EVCPLNQARPHCRLVALDGHLYAIGGE- 597
           L +V G   GP   PS+ V  Y+     W    + P N A  HC +V ++  L+ +GGE 
Sbjct: 324 LLLVGGLPPGPDRLPSNLVQYYDDEKKTWKILTIMPYNSAH-HC-VVEVENFLFVLGGED 381

Query: 598 --------CLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG 641
                     N V RYDPR + W   PP+       +  A    K ++V GG
Sbjct: 382 QWNPNGKHSTNFVSRYDPRFNSWIQLPPMQER--RASFYACRLDKHLYVIGG 431



 Score = 34.7 bits (78), Expect = 0.35
 Identities = 24/90 (26%), Positives = 36/90 (40%), Gaps = 1/90 (1%)

Query: 508 LCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTG 567
           L CYD   DVW     M  +      A+ +   Y    +  +G  H     V CY+P   
Sbjct: 488 LYCYDPVMDVWARKQDMNTKRAIHTLAVMNDRLYAIGGNHLKGFSHLDVMLVECYDPKGD 547

Query: 568 IWSEV-CPLNQARPHCRLVALDGHLYAIGG 596
            W+ +  P+ + R       LD  +Y +GG
Sbjct: 548 QWNILQTPILEGRSGPGCAVLDDSIYLVGG 577



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 21/64 (32%), Positives = 29/64 (45%), Gaps = 3/64 (4%)

Query: 510 CYDDEQDVWRPLARMPPEAVSR-GCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGI 568
           CYD + D W  L     E  S  GCA+  L + +++V G         S   CY P  G 
Sbjct: 541 CYDPKGDQWNILQTPILEGRSGPGCAV--LDDSIYLVGGYSWSMGAYKSSTICYCPEKGT 598

Query: 569 WSEV 572
           W+E+
Sbjct: 599 WTEL 602


>gi|31542246 kelch-like 36 [Homo sapiens]
          Length = 616

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 63/246 (25%), Positives = 97/246 (39%), Gaps = 25/246 (10%)

Query: 403 REPHVQPVAGTNFFHIPLTPASAPQVRLDLGNCYEVLTLAKRQNLEALKEAAYKVMSENY 462
           RE H + V      H PL P +    R+    C     L K  N E   E A +  +   
Sbjct: 224 REAHARQVLEN--IHFPLIPKNDLLHRVKPAVCS---LLPKEANCEGFIEEAVRYHNNLA 278

Query: 463 LQVLRSPDIYGCLSGAERELILQRRLRGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPLA 522
            Q +         +  ER L +           V++ C  E S   C  D + + W    
Sbjct: 279 AQPVMQTKRTALRTNQERLLFVGGE--------VSERC-LELSDDTCYLDAKSEQWVKET 329

Query: 523 RMPPEAVSRGCAICSLFNYLFVVSGC---QGPGHQPSSRVFCYNPLTGIWSEVCPLNQAR 579
            +P    S  C +  L  ++F+  G       G   S+ ++ Y+P    W +V  +NQ R
Sbjct: 330 PLPARR-SHHC-VAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMNQRR 387

Query: 580 PHCRLVALDGHLYAIGGE----CLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKE 635
               L +++  L AIGG      L+SVE Y P+ D W +   LP   F   H  T+    
Sbjct: 388 VDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLP--RFTYGHAGTIYKDF 445

Query: 636 IFVTGG 641
           ++++GG
Sbjct: 446 VYISGG 451



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 32/122 (26%), Positives = 47/122 (38%), Gaps = 12/122 (9%)

Query: 508 LCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSS----RVFCYN 563
           L CYD   DVW    R P        ++CSL + ++ + G               V  Y+
Sbjct: 463 LLCYDHRTDVWEE--RRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYS 520

Query: 564 PLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG------ECLNSVERYDPRLDRWDFAPP 617
           P    W+ V PL  A     +   +G +Y +GG          +V+ YD   D+W     
Sbjct: 521 PQCNQWTRVAPLLHANSESGVAVWEGRIYILGGYSWENTAFSKTVQVYDREADKWSRGVD 580

Query: 618 LP 619
           LP
Sbjct: 581 LP 582



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/119 (26%), Positives = 48/119 (40%), Gaps = 14/119 (11%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQ-GPGHQPSSRVFCYNPLTGIW 569
           Y  + D W  +A +P         I   F Y+      Q GP  +    + CY+  T +W
Sbjct: 417 YSPKTDSWSYVAGLPRFTYGHAGTIYKDFVYISGGHDYQIGPYRK---NLLCYDHRTDVW 473

Query: 570 SEVCPLNQARPHCRLVALDGHLYAIGGECLN----------SVERYDPRLDRWDFAPPL 618
            E  P+  AR    + +L   +Y+IGG   N           VE Y P+ ++W    PL
Sbjct: 474 EERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRVAPL 532


>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
          Length = 571

 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 62/242 (25%), Positives = 99/242 (40%), Gaps = 20/242 (8%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQG---PG---HQPSSRVFCYNP 564
           Y  + D W  LA +       G  IC L   ++V+ G      PG    +  + V C+NP
Sbjct: 304 YFPQNDSWIGLAPLNIPRYEFG--ICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNP 361

Query: 565 LTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLPS 620
            T  W+ +  +N++R    +V L G LYA+GG      L SVE+Y P++ +W   P  P 
Sbjct: 362 DTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQ--PVAPM 419

Query: 621 DTFALAHTATVRAKEIFVTGG---SLRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNG 677
            T      A V    I+  GG   +    + R+   +  W    +   K     +  + G
Sbjct: 420 TTTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLG 479

Query: 678 FLYRFDLNRSLG--IAVYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVGRRSTLC 735
           F++    +  +    ++ R       W  C   + P       AV+DN +Y VG  S   
Sbjct: 480 FIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEP-RTGVGAAVIDNYLYVVGGHSGSS 538

Query: 736 FL 737
           +L
Sbjct: 539 YL 540



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 8/106 (7%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD  +D W  +A M  + +  G  +  +  ++FVV G  G  H  S  +  Y+P    W+
Sbjct: 452 YDPSKDSWEMVASMADKRIHFGVGV--MLGFIFVVGGHNGVSHLSS--IERYDPHQNQWT 507

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGGEC----LNSVERYDPRLDRW 612
              P+ + R       +D +LY +GG      LN+V++YDP  D W
Sbjct: 508 VCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTW 553



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 43/161 (26%), Positives = 66/161 (40%), Gaps = 28/161 (17%)

Query: 591 LYAIGGE-----CLNSVERYDPRLDRWDFAPPL--PSDTFALAHTATVRAKEIFVTGGSL 643
           L A+GG+     CL+SVE Y P+ D W    PL  P   F +     V  ++++V GG  
Sbjct: 285 LCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGIC----VLDQKVYVIGGIA 340

Query: 644 R-----FLLFRFSAQEQRW------WAGPTGGSKDR-TAEMVAVNGFLYR---FDLNRSL 688
                   + +     + W      W      ++ R T  +V + G LY    +D  +S 
Sbjct: 341 TNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYD-GQSY 399

Query: 689 GIAVYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVG 729
             +V +     R W   A   T     F  AV+D +IY +G
Sbjct: 400 LQSVEKYIPKIRKWQPVAPMTTT-RSCFAAAVLDGMIYAIG 439


>gi|34101268 kelch-like 8 [Homo sapiens]
          Length = 620

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 48/135 (35%), Positives = 63/135 (46%), Gaps = 10/135 (7%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD E D W  +A  P      G    +L N+++ V G    G    S V  Y+P    W 
Sbjct: 433 YDIESDQWSTVA--PMNTPRGGVGSVALVNHVYAVGG--NDGMASLSSVERYDPHLDKWI 488

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLPSDTFALA 626
           EV  + Q R    +  L G LY +GG      L+SVERYDPR ++WD+   L +    + 
Sbjct: 489 EVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVG 548

Query: 627 HTATVRAKEIFVTGG 641
             ATV  K IF  GG
Sbjct: 549 -IATVMGK-IFAVGG 561



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 64/241 (26%), Positives = 94/241 (39%), Gaps = 23/241 (9%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRG--CAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTG 567
           CY   ++ W       PE  SR     + S+   ++ V G  G  H  S  +F  +PLT 
Sbjct: 338 CYSINKNSWF----FGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMF--DPLTN 391

Query: 568 IWSEVCPLNQARPHCRLVALDGHLYAIGG----ECLNSVERYDPRLDRWDFAPPLPSDTF 623
            W     +N  R    L +L G +YAIGG     C N VERYD   D+W    P+ +   
Sbjct: 392 KWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRG 451

Query: 624 ALAHTATVRAKEIFVTGGSLRFL----LFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFL 679
            +   A V    ++  GG+        + R+     +W      G +     +  ++G L
Sbjct: 452 GVGSVALV--NHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCL 509

Query: 680 Y---RFDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAVVDNLIYCVGRRSTLCF 736
           Y    FD N  L  +V R    +  W   A   TP       A V   I+ VG  +   +
Sbjct: 510 YVVGGFDDNSPLS-SVERYDPRSNKWDYVAALTTP-RGGVGIATVMGKIFAVGGHNGNAY 567

Query: 737 L 737
           L
Sbjct: 568 L 568



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 39/114 (34%), Positives = 56/114 (49%), Gaps = 8/114 (7%)

Query: 503 EDSGGLCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCY 562
           E  G +  +D   + W   A M  +   RG A+ SL   ++ + G     +   + V  Y
Sbjct: 378 EHLGSMEMFDPLTNKWMMKASMNTKR--RGIALASLGGPIYAIGGLDD--NTCFNDVERY 433

Query: 563 NPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGE----CLNSVERYDPRLDRW 612
           +  +  WS V P+N  R     VAL  H+YA+GG      L+SVERYDP LD+W
Sbjct: 434 DIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKW 487



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 33/107 (30%), Positives = 48/107 (44%), Gaps = 8/107 (7%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD   D W  +  M       G  +  L   L+VV G     + P S V  Y+P +  W 
Sbjct: 480 YDPHLDKWIEVKEMGQRRAGNG--VSKLHGCLYVVGGFDD--NSPLSSVERYDPRSNKWD 535

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGGE----CLNSVERYDPRLDRWD 613
            V  L   R    +  + G ++A+GG      LN+VE +DP L+RW+
Sbjct: 536 YVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWE 582



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 25/75 (33%), Positives = 39/75 (52%), Gaps = 5/75 (6%)

Query: 542 LFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----E 597
           LF V G  G G  P   + CY+     W     +N  R H  +++++G +YA+GG    E
Sbjct: 320 LFCVGGRGGSG-DPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNE 378

Query: 598 CLNSVERYDPRLDRW 612
            L S+E +DP  ++W
Sbjct: 379 HLGSMEMFDPLTNKW 393


>gi|23397572 kelch-like 34 [Homo sapiens]
          Length = 644

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 56/190 (29%), Positives = 82/190 (43%), Gaps = 29/190 (15%)

Query: 518 WRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPS----------SRVFCYNPLTG 567
           WR L ++P   +  G ++C+  N+LFV+ G    G   S          ++V  Y+P   
Sbjct: 346 WRSLTQLPTPLL--GHSVCTAGNFLFVLGGESPSGSASSPLADDSRVVTAQVHRYDPRFH 403

Query: 568 IWSEVCPLNQARPHCRLVALDGHLYAIGG-----ECLNSVERYDPRLDRWDFAPPLPSDT 622
            W+EV  + +AR H    A+   L A+GG     E L SVE YD R DRW  A  LP   
Sbjct: 404 AWTEVPAMREARAHFWCGAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRAL 463

Query: 623 FALAHTATVRAKEIFVTGG----------SLRFLLFRFSAQEQRWWAGPTGGSKDRTAEM 672
              A     R   ++++GG          SLR  L+    +EQ W      G+      M
Sbjct: 464 HGHAGAVGDRG-VVYISGGKAGRGEGGASSLRD-LYVLGPEEQVWSKKAPMGTARFGHHM 521

Query: 673 VAVNGFLYRF 682
             + G ++ F
Sbjct: 522 AVLRGAVFAF 531



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 33/118 (27%), Positives = 51/118 (43%), Gaps = 6/118 (5%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRV---FCYNPLTG 567
           YD  +D W     +P        A+      +++  G  G G   +S +   +   P   
Sbjct: 446 YDLRRDRWTAAGALPRALHGHAGAVGDR-GVVYISGGKAGRGEGGASSLRDLYVLGPEEQ 504

Query: 568 IWSEVCPLNQARPHCRLVALDGHLYAIGG--ECLNSVERYDPRLDRWDFAPPLPSDTF 623
           +WS+  P+  AR    +  L G ++A  G  E  + +ERYDP  D+W    PLP D F
Sbjct: 505 VWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSEIERYDPGADQWTRLRPLPYDRF 562


>gi|166235129 kelch-like 3 [Homo sapiens]
          Length = 587

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 49/180 (27%), Positives = 77/180 (42%), Gaps = 16/180 (8%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD  +D W  +A M     + G A+  L + L+ V G  G     S   + Y   T  W 
Sbjct: 367 YDGVKDQWTSIASMQERRSTLGAAV--LNDLLYAVGGFDGSTGLASVEAYSYK--TNEWF 422

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG------ECLNSVERYDPRLDRWDFAPPLPSDTFA 624
            V P+N  R    +  ++G LYA+GG      +CL++VE+Y+P  + W +   +   T  
Sbjct: 423 FVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADM--STRR 480

Query: 625 LAHTATVRAKEIFVTGGS----LRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLY 680
                 V + +++ TGG     +R  +  +      W          R A + AVNG LY
Sbjct: 481 SGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLY 540



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 38/125 (30%), Positives = 57/125 (45%), Gaps = 8/125 (6%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           Y+   + W  +A M       G  + S    L+   G  GP  + S  V  Y+P T  W 
Sbjct: 463 YNPATNEWIYVADMSTRRSGAGVGVLS--GQLYATGGHDGPLVRKSVEV--YDPGTNTWK 518

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGGE---C-LNSVERYDPRLDRWDFAPPLPSDTFALA 626
           +V  +N  R +  + A++G LY +GG+   C L SVE Y+P  D+W   P   S   + A
Sbjct: 519 QVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMSTGRSYA 578

Query: 627 HTATV 631
             A +
Sbjct: 579 GVAVI 583



 Score = 34.7 bits (78), Expect = 0.35
 Identities = 40/154 (25%), Positives = 60/154 (38%), Gaps = 12/154 (7%)

Query: 585 VALDGHLYAIGGEC---LNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG 641
           V+L   +  +GG+    + SVE YD   DRWD    LPS            A  ++  GG
Sbjct: 297 VSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAG--VVFMAGHVYAVGG 354

Query: 642 SLRFLLFR----FSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRF-DLNRSLGIA-VYRC 695
               L  R    +   + +W +  +   +  T     +N  LY     + S G+A V   
Sbjct: 355 FNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAY 414

Query: 696 SASTRLWYECATYRTPYPDAFQCAVVDNLIYCVG 729
           S  T  W+  A   T    +    VV+  +Y VG
Sbjct: 415 SYKTNEWFFVAPMNT-RRSSVGVGVVEGKLYAVG 447



 Score = 34.7 bits (78), Expect = 0.35
 Identities = 22/75 (29%), Positives = 36/75 (48%), Gaps = 6/75 (8%)

Query: 542 LFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----E 597
           + +V G Q P  +    V CY+     W ++  L   R    +V + GH+YA+GG     
Sbjct: 302 VMIVVGGQAP--KAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSL 359

Query: 598 CLNSVERYDPRLDRW 612
            + +V+ YD   D+W
Sbjct: 360 RVRTVDVYDGVKDQW 374


>gi|24432026 kelch-like [Homo sapiens]
          Length = 634

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 39/125 (31%), Positives = 52/125 (41%), Gaps = 10/125 (8%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPG--HQPSSRVFCYNPLTG 567
           CYD   + W  LA  P      G A  +L N L+V+ G        +   +V CY+  +G
Sbjct: 465 CYDPGSNTWHTLADGPVRRAWHGMA--TLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSG 522

Query: 568 IWSEVCPLNQARPHCRLVALDGHLYAIGGECLNSVER------YDPRLDRWDFAPPLPSD 621
            WS VCPL        +  LD  +Y +GG   N   R      YD   D W+  P L + 
Sbjct: 523 QWSSVCPLPAGHGEPGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEGPQLDNS 582

Query: 622 TFALA 626
              LA
Sbjct: 583 ISGLA 587



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 55/227 (24%), Positives = 92/227 (40%), Gaps = 22/227 (9%)

Query: 522 ARMPPEAVSRGCAICSLFNYLFVVSGCQG-PGHQPSSRVFCYNPLTGIWSEVCPLNQARP 580
           A + P   ++G A+  L N+++++ G     G +  SR + Y+P    W ++  L Q   
Sbjct: 333 ASLAPRMSNQGIAV--LNNFVYLIGGDNNVQGFRAESRCWRYDPRHNRWFQIQSLQQEHA 390

Query: 581 HCRLVALDGHLYAIGGEC----LNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEI 636
              +  +  ++YA+ G      LN+VERYDP  + W +  PL  + +  AH       ++
Sbjct: 391 DLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREVY--AHAGATLEGKM 448

Query: 637 FVTGGSLRFLLFR----FSAQEQRWWAGPTGGSKDRTAEMVAVNGFLYRFDLNRSLGIAV 692
           ++T G       +    +      W     G  +     M  +   LY   +  S   A 
Sbjct: 449 YITCGRRGEDYLKETHCYDPGSNTWHTLADGPVRRAWHGMATLLNKLY--VIGGSNNDAG 506

Query: 693 YRCSASTRLWYECATYR----TPYPDAF---QCAVVDNLIYCVGRRS 732
           YR        Y C + +     P P        AV+DN IY +G RS
Sbjct: 507 YRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDNRIYVLGGRS 553


>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
          Length = 505

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 37/107 (34%), Positives = 54/107 (50%), Gaps = 8/107 (7%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIW 569
           CY+   + W  +A M       G  +  L N L+ V G  GP  + S  V  Y+P T  W
Sbjct: 380 CYNATTNEWTYIAEMSTRRSGAGVGV--LNNLLYAVGGHDGPLVRKSVEV--YDPTTNAW 435

Query: 570 SEVCPLNQARPHCRLVALDGHLYAIGGE---C-LNSVERYDPRLDRW 612
            +V  +N  R +  + A++G LY +GG+   C L SVE Y+P  D+W
Sbjct: 436 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 482



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 48/180 (26%), Positives = 71/180 (39%), Gaps = 16/180 (8%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD  +D W  +A M     + G A+  L   L+ V G  G      S V  YN  +  W 
Sbjct: 285 YDPVKDQWTSVANMRDRRSTLGAAV--LNGLLYAVGGFDGS--TGLSSVEAYNIKSNEWF 340

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG------ECLNSVERYDPRLDRWDFAPPLPSDTFA 624
            V P+N  R    +  + G LYA+GG      +CL++VE Y+   + W +   +   T  
Sbjct: 341 HVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM--STRR 398

Query: 625 LAHTATVRAKEIFVTGGS----LRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLY 680
                 V    ++  GG     +R  +  +      W          R A + AVNG LY
Sbjct: 399 SGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLY 458



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 48/200 (24%), Positives = 81/200 (40%), Gaps = 17/200 (8%)

Query: 542 LFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----E 597
           L VV G Q P  +    V CY+     W +V  L   R    +V + G ++A+GG     
Sbjct: 220 LMVVVGGQAP--KAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSL 277

Query: 598 CLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG----SLRFLLFRFSAQ 653
            + +V+ YDP  D+W     +      L   A V    ++  GG    +    +  ++ +
Sbjct: 278 RVRTVDSYDPVKDQWTSVANMRDRRSTLG--AAVLNGLLYAVGGFDGSTGLSSVEAYNIK 335

Query: 654 EQRWWAGPTGGSKDRTAEMVAVNGFLYR---FDLNRSLGIAVYRC-SASTRLWYECATYR 709
              W+      ++  +  +  V G LY    +D      ++   C +A+T  W   A   
Sbjct: 336 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 395

Query: 710 TPYPDAFQCAVVDNLIYCVG 729
           T    A    V++NL+Y VG
Sbjct: 396 TRRSGA-GVGVLNNLLYAVG 414


>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
          Length = 597

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 37/107 (34%), Positives = 54/107 (50%), Gaps = 8/107 (7%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIW 569
           CY+   + W  +A M       G  +  L N L+ V G  GP  + S  V  Y+P T  W
Sbjct: 472 CYNATTNEWTYIAEMSTRRSGAGVGV--LNNLLYAVGGHDGPLVRKSVEV--YDPTTNAW 527

Query: 570 SEVCPLNQARPHCRLVALDGHLYAIGGE---C-LNSVERYDPRLDRW 612
            +V  +N  R +  + A++G LY +GG+   C L SVE Y+P  D+W
Sbjct: 528 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 574



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 48/180 (26%), Positives = 71/180 (39%), Gaps = 16/180 (8%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD  +D W  +A M     + G A+  L   L+ V G  G      S V  YN  +  W 
Sbjct: 377 YDPVKDQWTSVANMRDRRSTLGAAV--LNGLLYAVGGFDGS--TGLSSVEAYNIKSNEWF 432

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG------ECLNSVERYDPRLDRWDFAPPLPSDTFA 624
            V P+N  R    +  + G LYA+GG      +CL++VE Y+   + W +   +   T  
Sbjct: 433 HVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM--STRR 490

Query: 625 LAHTATVRAKEIFVTGGS----LRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLY 680
                 V    ++  GG     +R  +  +      W          R A + AVNG LY
Sbjct: 491 SGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLY 550



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 48/200 (24%), Positives = 81/200 (40%), Gaps = 17/200 (8%)

Query: 542 LFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----E 597
           L VV G Q P  +    V CY+     W +V  L   R    +V + G ++A+GG     
Sbjct: 312 LMVVVGGQAP--KAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSL 369

Query: 598 CLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG----SLRFLLFRFSAQ 653
            + +V+ YDP  D+W     +      L   A V    ++  GG    +    +  ++ +
Sbjct: 370 RVRTVDSYDPVKDQWTSVANMRDRRSTLG--AAVLNGLLYAVGGFDGSTGLSSVEAYNIK 427

Query: 654 EQRWWAGPTGGSKDRTAEMVAVNGFLYR---FDLNRSLGIAVYRC-SASTRLWYECATYR 709
              W+      ++  +  +  V G LY    +D      ++   C +A+T  W   A   
Sbjct: 428 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 487

Query: 710 TPYPDAFQCAVVDNLIYCVG 729
           T    A    V++NL+Y VG
Sbjct: 488 TRRSGA-GVGVLNNLLYAVG 506


>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
          Length = 593

 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 37/107 (34%), Positives = 54/107 (50%), Gaps = 8/107 (7%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIW 569
           CY+   + W  +A M       G  +  L N L+ V G  GP  + S  V  Y+P T  W
Sbjct: 468 CYNATTNEWTYIAEMSTRRSGAGVGV--LNNLLYAVGGHDGPLVRKSVEV--YDPTTNAW 523

Query: 570 SEVCPLNQARPHCRLVALDGHLYAIGGE---C-LNSVERYDPRLDRW 612
            +V  +N  R +  + A++G LY +GG+   C L SVE Y+P  D+W
Sbjct: 524 RQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 570



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 48/180 (26%), Positives = 71/180 (39%), Gaps = 16/180 (8%)

Query: 511 YDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIWS 570
           YD  +D W  +A M     + G A+  L   L+ V G  G      S V  YN  +  W 
Sbjct: 373 YDPVKDQWTSVANMRDRRSTLGAAV--LNGLLYAVGGFDGS--TGLSSVEAYNIKSNEWF 428

Query: 571 EVCPLNQARPHCRLVALDGHLYAIGG------ECLNSVERYDPRLDRWDFAPPLPSDTFA 624
            V P+N  R    +  + G LYA+GG      +CL++VE Y+   + W +   +   T  
Sbjct: 429 HVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM--STRR 486

Query: 625 LAHTATVRAKEIFVTGGS----LRFLLFRFSAQEQRWWAGPTGGSKDRTAEMVAVNGFLY 680
                 V    ++  GG     +R  +  +      W          R A + AVNG LY
Sbjct: 487 SGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLY 546



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 48/200 (24%), Positives = 81/200 (40%), Gaps = 17/200 (8%)

Query: 542 LFVVSGCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG----E 597
           L VV G Q P  +    V CY+     W +V  L   R    +V + G ++A+GG     
Sbjct: 308 LMVVVGGQAP--KAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSL 365

Query: 598 CLNSVERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGG----SLRFLLFRFSAQ 653
            + +V+ YDP  D+W     +      L   A V    ++  GG    +    +  ++ +
Sbjct: 366 RVRTVDSYDPVKDQWTSVANMRDRRSTLG--AAVLNGLLYAVGGFDGSTGLSSVEAYNIK 423

Query: 654 EQRWWAGPTGGSKDRTAEMVAVNGFLYR---FDLNRSLGIAVYRC-SASTRLWYECATYR 709
              W+      ++  +  +  V G LY    +D      ++   C +A+T  W   A   
Sbjct: 424 SNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMS 483

Query: 710 TPYPDAFQCAVVDNLIYCVG 729
           T    A    V++NL+Y VG
Sbjct: 484 TRRSGA-GVGVLNNLLYAVG 502


>gi|55925608 kelch-like 21 [Homo sapiens]
          Length = 597

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 41/134 (30%), Positives = 64/134 (47%), Gaps = 9/134 (6%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGPGHQPSSRVFCYNPLTGIW 569
           CY+ +   WR LA  P + +  G +I +L N ++V  G  G   +    V+ YN     W
Sbjct: 306 CYNPQTGQWRYLAEFP-DHLGGGYSIVALGNDIYVTGGSDGS--RLYDCVWRYNSSVNEW 362

Query: 570 SEVCPLNQARPHCRLVALDGHLYAIGGECLNSVERYDPRLDRWDFAPPLPSDTFALAHTA 629
           +EV P+ +AR +     LDG LY +  +   S ERYD   D W+   P+   T+ + + +
Sbjct: 363 AEVAPMLKAREYHSSSVLDGLLYVVAAD---STERYDHTTDSWEALQPM---TYPMDNCS 416

Query: 630 TVRAKEIFVTGGSL 643
           T   +      GSL
Sbjct: 417 TTACRGRLYAIGSL 430



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 41/142 (28%), Positives = 57/142 (40%), Gaps = 18/142 (12%)

Query: 489 RGRQYLVVADVCPKEDSGGLCCYDDEQDVWRPL--ARMPPEAVSRGCAICSLFNYLFVVS 546
           RGR Y  +  +  KE    + CYD + D+W  +   ++PP + +   A  +   Y     
Sbjct: 421 RGRLY-AIGSLAGKETMV-MQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFV--- 475

Query: 547 GCQGPGHQPSSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGG-----ECLNS 601
                    S+ V  YNP    W ++  +NQ      L  L G LY  GG     E  + 
Sbjct: 476 ------RDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDV 529

Query: 602 VERYDPRLDRWDFAPPLPSDTF 623
           VE YDP    W     LP  TF
Sbjct: 530 VEAYDPETRAWSVVGRLPEPTF 551


>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
          Length = 586

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 37/119 (31%), Positives = 58/119 (48%), Gaps = 14/119 (11%)

Query: 510 CYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFVVSGCQGP-GHQPSSRVF----CYNP 564
           CYD   + W     M  +  S G    +   Y+     C G  G+  S RV      Y+P
Sbjct: 402 CYDTRTESWHTKPSMLTQRCSHGMVEANGLIYV-----CGGSLGNNVSGRVLNSCEVYDP 456

Query: 565 LTGIWSEVCPLNQARPHCRLVALDGHLYAIGGE----CLNSVERYDPRLDRWDFAPPLP 619
            T  W+E+CP+ +AR +  LV +   ++A+GG+     L++VE YD +L+ W    P+P
Sbjct: 457 ATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMP 515



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 38/140 (27%), Positives = 62/140 (44%), Gaps = 17/140 (12%)

Query: 552 GHQPSSRVFCYNPLTGIWSEV-CPLNQARPHCRLVALDGHLYAIGGECLNSVER---YDP 607
           G QP S  + +NP    W+++ CP  + R     V  D  +Y +GG  L  ++R   Y+ 
Sbjct: 300 GSQPQSCRY-FNPKDYSWTDIRCPFEKRRD-AACVFWDNVVYILGGSQLFPIKRMDCYNV 357

Query: 608 RLDRW--DFAPPLPSDTFALAHTATVRAKEIFVTGGS-----LRFLLFRFSAQEQRWWAG 660
             D W     PP P D+ A    A     +I+ +GGS       +L   +  + + W   
Sbjct: 358 VKDSWYSKLGPPTPRDSLA----ACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTK 413

Query: 661 PTGGSKDRTAEMVAVNGFLY 680
           P+  ++  +  MV  NG +Y
Sbjct: 414 PSMLTQRCSHGMVEANGLIY 433



 Score = 36.2 bits (82), Expect = 0.12
 Identities = 39/141 (27%), Positives = 54/141 (38%), Gaps = 13/141 (9%)

Query: 509 CCYDDEQDVWRPLARMPPEAVSRGCAICSLF-NYLFVVSGCQGPGHQPSSRVFCYNPLTG 567
           C Y + +D      R P E   R  A C  + N ++++ G Q     P  R+ CYN +  
Sbjct: 306 CRYFNPKDYSWTDIRCPFE--KRRDAACVFWDNVVYILGGSQ---LFPIKRMDCYNVVKD 360

Query: 568 IWSEVCPLNQARPHCRLVALDGHLYAIGG-----ECLNSVERYDPRLDRWDFAPPLPSDT 622
            W         R      A +G +Y  GG       L   E YD R + W   P +   T
Sbjct: 361 SWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSML--T 418

Query: 623 FALAHTATVRAKEIFVTGGSL 643
              +H        I+V GGSL
Sbjct: 419 QRCSHGMVEANGLIYVCGGSL 439


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.135    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,845,150
Number of Sequences: 37866
Number of extensions: 2114466
Number of successful extensions: 11856
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 78
Number of HSP's successfully gapped in prelim test: 401
Number of HSP's that attempted gapping in prelim test: 10549
Number of HSP's gapped (non-prelim): 1445
length of query: 777
length of database: 18,247,518
effective HSP length: 110
effective length of query: 667
effective length of database: 14,082,258
effective search space: 9392866086
effective search space used: 9392866086
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.