Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 22779870
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22779870 PDLIM1 interacting kinase 1 like [Homo sapiens]
(341 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22779870 PDLIM1 interacting kinase 1 like [Homo sapiens] 682 0.0
gi|20128768 serine/threonine kinase 35 [Homo sapiens] 460 e-130
gi|23943882 serine/threonine kinase 33 [Homo sapiens] 117 1e-26
gi|4507831 Unc-51-like kinase 1 [Homo sapiens] 95 1e-19
gi|148839316 NIMA-related kinase 4 [Homo sapiens] 93 4e-19
gi|217330559 unc-51-like kinase 2 [Homo sapiens] 92 7e-19
gi|217330557 unc-51-like kinase 2 [Homo sapiens] 92 7e-19
gi|150456432 unc-51-like kinase 3 [Homo sapiens] 91 1e-18
gi|4758128 doublecortin-like kinase 1 [Homo sapiens] 87 2e-17
gi|116089335 BR serine/threonine kinase 2 [Homo sapiens] 86 5e-17
gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens] 86 6e-17
gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens] 86 6e-17
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens] 84 2e-16
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens] 84 2e-16
gi|193083129 MAP/microtubule affinity-regulating kinase 3 isofor... 84 2e-16
gi|193083127 MAP/microtubule affinity-regulating kinase 3 isofor... 84 2e-16
gi|193083125 MAP/microtubule affinity-regulating kinase 3 isofor... 84 2e-16
gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform... 84 2e-16
gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo s... 83 3e-16
gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo ... 83 3e-16
gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo ... 83 3e-16
gi|24308326 BR serine/threonine kinase 1 [Homo sapiens] 83 3e-16
gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo sapi... 82 9e-16
gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo sapi... 82 9e-16
gi|7657214 hormonally upregulated Neu-associated kinase [Homo sa... 82 9e-16
gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo s... 80 2e-15
gi|209364621 pregnancy upregulated non-ubiquitously expressed Ca... 80 3e-15
gi|209364619 pregnancy upregulated non-ubiquitously expressed Ca... 80 3e-15
gi|149589021 doublecortin-like kinase 3 [Homo sapiens] 80 3e-15
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 80 3e-15
>gi|22779870 PDLIM1 interacting kinase 1 like [Homo sapiens]
Length = 341
Score = 682 bits (1759), Expect = 0.0
Identities = 341/341 (100%), Positives = 341/341 (100%)
Query: 1 MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVELALREFWALSSI 60
MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVELALREFWALSSI
Sbjct: 1 MVSSQPKYDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVELALREFWALSSI 60
Query: 61 KSQHPNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMD 120
KSQHPNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMD
Sbjct: 61 KSQHPNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMD 120
Query: 121 FCDGGDMNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTS 180
FCDGGDMNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTS
Sbjct: 121 FCDGGDMNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTS 180
Query: 181 DLEPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKADI 240
DLEPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKADI
Sbjct: 181 DLEPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKADI 240
Query: 241 FALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSM 300
FALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSM
Sbjct: 241 FALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSM 300
Query: 301 NGRMKQLIKEMLAANPQDRPDAFELELRLVQIAFKDSSWET 341
NGRMKQLIKEMLAANPQDRPDAFELELRLVQIAFKDSSWET
Sbjct: 301 NGRMKQLIKEMLAANPQDRPDAFELELRLVQIAFKDSSWET 341
>gi|20128768 serine/threonine kinase 35 [Homo sapiens]
Length = 401
Score = 460 bits (1184), Expect = e-130
Identities = 235/339 (69%), Positives = 283/339 (83%), Gaps = 14/339 (4%)
Query: 3 SSQPKYDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVELALREFWALSSIKS 62
S++P+Y L+ E+GRGSYGVVYEAV ++ ARVAVKKIRC APENVELAL EFWAL+S+K
Sbjct: 64 SARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCDAPENVELALAEFWALTSLKR 123
Query: 63 QHPNVIHLEECILQKDGMVQKMSHGSNSS-LYLQLVETSLKGE-IAFDPRSAYYLWFVMD 120
+H NV+ EEC+LQ++G+ Q+MSHG+ SS LYL+LVETSLKGE I YLWFVM+
Sbjct: 124 RHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLWFVME 183
Query: 121 FCDGGDMNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTS 180
FC+GGD+N+Y+LSR+P+ TN SFMLQL+SA+AFLHKN I+HRDLKPDNILI++ R T
Sbjct: 184 FCEGGDLNQYVLSRRPDPATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITE-RSGT- 241
Query: 181 DLEPTLKVADFGLSKVCSA------SGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEGHY 234
P LKVADFGLSKVC+ G + V+VNK +LS+ACG+DFYMAPEVWEGHY
Sbjct: 242 ---PILKVADFGLSKVCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGHY 298
Query: 235 TAKADIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIP 294
TAKADIFALGIIIWAM+ERITFID+ETKKELLG+Y+KQGTEIVPVGEALLENPKMEL IP
Sbjct: 299 TAKADIFALGIIIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIP 358
Query: 295 VKKK-SMNGRMKQLIKEMLAANPQDRPDAFELELRLVQI 332
K++ SM+ +KQL+K+MLAANPQDRPDAFELE R+ Q+
Sbjct: 359 QKRRTSMSEGIKQLLKDMLAANPQDRPDAFELETRMDQV 397
>gi|23943882 serine/threonine kinase 33 [Homo sapiens]
Length = 514
Score = 117 bits (294), Expect = 1e-26
Identities = 91/323 (28%), Positives = 157/323 (48%), Gaps = 68/323 (21%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPEN--VELALREFWALSSIKSQHP 65
Y R +G+GS+G+V EA ++T + A+KK+ + V+L RE L S+K +H
Sbjct: 116 YTFGRILGKGSFGIVIEATDKETETKWAIKKVNKEKAGSSAVKLLEREVNILKSVKHEH- 174
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
+IHLE Q+ ET K ++ VM+ C+ G
Sbjct: 175 -IIHLE-----------------------QVFETPKK------------MYLVMELCEDG 198
Query: 126 DMNEYLLSRKPNRKTNTSFMLQ-LSSALAFLHKNQIIHRDLKPDNILISQTRL-DTSDLE 183
++ E L + + T +++Q L+SA+A+LH N I+HRDLK +NI++ + + D +++
Sbjct: 199 ELKEILDRKGHFSENETRWIIQSLASAIAYLHNNDIVHRDLKLENIMVKSSLIDDNNEIN 258
Query: 184 PTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEGH-YTAKADIFA 242
+KV DFGL+ + S ++ L CGT YMAPEV H Y+ + DI++
Sbjct: 259 LNIKVTDFGLA----------VKKQSRSEAMLQATCGTPIYMAPEVISAHDYSQQCDIWS 308
Query: 243 LGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSMNG 302
+G++++ +L + L S ++ E++ GE EN S++
Sbjct: 309 IGVVMYMLL--------RGEPPFLASSEEKLFELIRKGELHFENAVW--------NSISD 352
Query: 303 RMKQLIKEMLAANPQDRPDAFEL 325
K ++K+++ +P R A EL
Sbjct: 353 CAKSVLKQLMKVDPAHRITAKEL 375
>gi|4507831 Unc-51-like kinase 1 [Homo sapiens]
Length = 1050
Score = 94.7 bits (234), Expect = 1e-19
Identities = 88/324 (27%), Positives = 149/324 (45%), Gaps = 77/324 (23%)
Query: 7 KYDLIRE--VGRGSYGVVYEAVIR-KTSARVAVKKI-RCHAPENVELALREFWALSSIKS 62
K++ R+ +G G++ VV++ R K VAVK I + + ++ L +E L +K
Sbjct: 13 KFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELK- 71
Query: 63 QHPNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFC 122
H N++ L + Q+M++ S+YL VM++C
Sbjct: 72 -HENIVALYD--------FQEMAN----SVYL-----------------------VMEYC 95
Query: 123 DGGDMNEYLLS-RKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQ---TRLD 178
+GGD+ +YL + R + T F+ Q++ A+ LH IIHRDLKP NIL+S R +
Sbjct: 96 NGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRAN 155
Query: 179 TSDLEPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEV-WEGHYTAK 237
+ + +K+ADFG ++ ++ +T CG+ YMAPEV HY K
Sbjct: 156 PNSIR--VKIADFGFARYLQSN------------MMAATLCGSPMYMAPEVIMSQHYDGK 201
Query: 238 ADIFALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKK 297
AD++++G I++ L + ++L Y K T L+P
Sbjct: 202 ADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKT-----------------LVPTIP 244
Query: 298 KSMNGRMKQLIKEMLAANPQDRPD 321
+ + ++QL+ +L N +DR D
Sbjct: 245 RETSAPLRQLLLALLQRNHKDRMD 268
>gi|148839316 NIMA-related kinase 4 [Homo sapiens]
Length = 841
Score = 92.8 bits (229), Expect = 4e-19
Identities = 77/319 (24%), Positives = 133/319 (41%), Gaps = 80/319 (25%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVELALREFWALSSIKSQHPNV 67
Y +R VG+GSYG V R+ + +KK+ + E E A + +HPN+
Sbjct: 6 YCYLRVVGKGSYGEVTLVKHRRDGKQYVIKKLNLRNASSRERRAAEQEAQLLSQLKHPNI 65
Query: 68 IHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGDM 127
+ +E DG+ L+ VM FC+GGD+
Sbjct: 66 VTYKESWEGGDGL----------------------------------LYIVMGFCEGGDL 91
Query: 128 NEYLLSRK----PNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLE 183
L +K P + + +Q++ AL +LH+ I+HRDLK N+ +++T +
Sbjct: 92 YRKLKEQKGQLLPENQV-VEWFVQIAMALQYLHEKHILHRDLKTQNVFLTRTNI------ 144
Query: 184 PTLKVADFGLSKVCSASGQNPEEPVSVNKC-FLSTACGTDFYMAPEVWEGH-YTAKADIF 241
+KV D G+++V N C ST GT +YM+PE++ Y K+D++
Sbjct: 145 --IKVGDLGIARVLE------------NHCDMASTLIGTPYYMSPELFSNKPYNYKSDVW 190
Query: 242 ALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSMN 301
ALG ++ M + + L+ + E +P + +
Sbjct: 191 ALGCCVYEMATLKHAFNAKDMNSLVYRII-------------------EGKLPPMPRDYS 231
Query: 302 GRMKQLIKEMLAANPQDRP 320
+ +LI+ ML+ P++RP
Sbjct: 232 PELAELIRTMLSKRPEERP 250
>gi|217330559 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 92.0 bits (227), Expect = 7e-19
Identities = 84/313 (26%), Positives = 138/313 (44%), Gaps = 71/313 (22%)
Query: 14 VGRGSYGVVYEAVIR-KTSARVAVKKIRCHAPENVELAL-REFWALSSIKSQHPNVIHLE 71
VG G++ VV+ R KT VA+K I ++ L +E L + QH N++ L
Sbjct: 15 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKEL--QHENIVALY 72
Query: 72 ECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGDMNEYL 131
+ VQ++ P S + VM++C+GGD+ +YL
Sbjct: 73 D--------VQEL------------------------PNSVF---LVMEYCNGGDLADYL 97
Query: 132 LSRKP-NRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEP-TLKVA 189
++ + T F+ Q+++A+ LH IIHRDLKP NIL+S S + +K+A
Sbjct: 98 QAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIA 157
Query: 190 DFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEV-WEGHYTAKADIFALGIIIW 248
DFG ++ ++ +T CG+ YMAPEV HY AKAD++++G +I+
Sbjct: 158 DFGFARYLHSN------------MMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIY 205
Query: 249 AMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSMNGRMKQLI 308
L + ++L Y K + L+P + + + L+
Sbjct: 206 QCLVGKPPFQANSPQDLRMFYEKNRS-----------------LMPSIPRETSPYLANLL 248
Query: 309 KEMLAANPQDRPD 321
+L N +DR D
Sbjct: 249 LGLLQRNQKDRMD 261
>gi|217330557 unc-51-like kinase 2 [Homo sapiens]
Length = 1036
Score = 92.0 bits (227), Expect = 7e-19
Identities = 84/313 (26%), Positives = 138/313 (44%), Gaps = 71/313 (22%)
Query: 14 VGRGSYGVVYEAVIR-KTSARVAVKKIRCHAPENVELAL-REFWALSSIKSQHPNVIHLE 71
VG G++ VV+ R KT VA+K I ++ L +E L + QH N++ L
Sbjct: 15 VGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSKSQILLGKEIKILKEL--QHENIVALY 72
Query: 72 ECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGDMNEYL 131
+ VQ++ P S + VM++C+GGD+ +YL
Sbjct: 73 D--------VQEL------------------------PNSVF---LVMEYCNGGDLADYL 97
Query: 132 LSRKP-NRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEP-TLKVA 189
++ + T F+ Q+++A+ LH IIHRDLKP NIL+S S + +K+A
Sbjct: 98 QAKGTLSEDTIRVFLHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIA 157
Query: 190 DFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEV-WEGHYTAKADIFALGIIIW 248
DFG ++ ++ +T CG+ YMAPEV HY AKAD++++G +I+
Sbjct: 158 DFGFARYLHSN------------MMAATLCGSPMYMAPEVIMSQHYDAKADLWSIGTVIY 205
Query: 249 AMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSMNGRMKQLI 308
L + ++L Y K + L+P + + + L+
Sbjct: 206 QCLVGKPPFQANSPQDLRMFYEKNRS-----------------LMPSIPRETSPYLANLL 248
Query: 309 KEMLAANPQDRPD 321
+L N +DR D
Sbjct: 249 LGLLQRNQKDRMD 261
>gi|150456432 unc-51-like kinase 3 [Homo sapiens]
Length = 472
Score = 90.9 bits (224), Expect = 1e-18
Identities = 73/249 (29%), Positives = 115/249 (46%), Gaps = 64/249 (25%)
Query: 10 LIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPEN-----VELALREFWALSSIKSQH 64
L +G G+Y VY+A +K + V I+C A ++ VE L E L I+ H
Sbjct: 16 LTERLGSGTYATVYKAYAKKDTREVVA--IKCVAKKSLNKASVENLLTEIEILKGIR--H 71
Query: 65 PNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDG 124
P+++ L++ D ++ +M+FC G
Sbjct: 72 PHIVQLKDFQWDSDN-----------------------------------IYLIMEFCAG 96
Query: 125 GDMNEYLLSRKP-NRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLE 183
GD++ ++ +R+ K FM QL+SAL FLH+ I H DLKP NIL+S +
Sbjct: 97 GDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLSSLE------K 150
Query: 184 PTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPE-VWEGHYTAKADIFA 242
P LK+ADFG A +P + V + G+ YMAPE V + Y A+ D+++
Sbjct: 151 PHLKLADFGF-----AQHMSPWDEKHVLR-------GSPLYMAPEMVCQRQYDARVDLWS 198
Query: 243 LGIIIWAML 251
+G+I++ L
Sbjct: 199 MGVILYEAL 207
>gi|4758128 doublecortin-like kinase 1 [Homo sapiens]
Length = 729
Score = 87.0 bits (214), Expect = 2e-17
Identities = 73/250 (29%), Positives = 113/250 (45%), Gaps = 62/250 (24%)
Query: 7 KYDLIREVGRGSYGVVYEAVIRKTSARVA---VKKIRCHAPENVELALREFWALSSIKSQ 63
+Y + R +G G++ VV E V R T+ A +KK +C E+ + E L +K
Sbjct: 389 RYKVGRTIGDGNFAVVKECVERSTAREYALKIIKKSKCRGKEH--MIQNEVSILRRVK-- 444
Query: 64 HPNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCD 123
HPN++ L E E + E L+ VM+
Sbjct: 445 HPNIVLLIE-------------------------EMDVPTE----------LYLVMELVK 469
Query: 124 GGDMNEYLLSRKPNRKTNTSFML-QLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDL 182
GGD+ + + S + + S ML L+SA+ +LH I+HRD+KP+N+L+ + D
Sbjct: 470 GGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLV----YEHQDG 525
Query: 183 EPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPE-VWEGHYTAKADIF 241
+LK+ DFGL+ + L T CGT Y+APE + E Y K DI+
Sbjct: 526 SKSLKLGDFGLATIVDGP--------------LYTVCGTPTYVAPEIIAETGYGLKVDIW 571
Query: 242 ALGIIIWAML 251
A G+I + +L
Sbjct: 572 AAGVITYILL 581
>gi|116089335 BR serine/threonine kinase 2 [Homo sapiens]
Length = 668
Score = 85.9 bits (211), Expect = 5e-17
Identities = 76/276 (27%), Positives = 126/276 (45%), Gaps = 63/276 (22%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKI-RCHAPENVELAL-REFWALSSIKSQHP 65
Y L + +G+G G+V V T +VA+K + R E+V + + RE L I +HP
Sbjct: 19 YRLEKTLGKGQTGLVKLGVHCVTCQKVAIKIVNREKLSESVLMKVEREIAILKLI--EHP 76
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
+V+ L + K YL+ V++ GG
Sbjct: 77 HVLKLHDVYENKK-----------------------------------YLYLVLEHVSGG 101
Query: 126 DMNEYLLSR-KPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEP 184
++ +YL+ + + K F Q+ SAL F H + I HRDLKP+N+L+ D +
Sbjct: 102 ELFDYLVKKGRLTPKEARKFFRQIISALDFCHSHSICHRDLKPENLLL--------DEKN 153
Query: 185 TLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADIFA 242
+++ADFG++ + V L T+CG+ Y PEV G + KAD+++
Sbjct: 154 NIRIADFGMAS------------LQVGDSLLETSCGSPHYACPEVIRGEKYDGRKADVWS 201
Query: 243 LGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVP 278
G+I++A+L D + ++LL VK+G +P
Sbjct: 202 CGVILFALLVGALPFDDDNLRQLL-EKVKRGVFHMP 236
>gi|156713430 doublecortin-like kinase 2 isoform b [Homo sapiens]
Length = 765
Score = 85.5 bits (210), Expect = 6e-17
Identities = 72/250 (28%), Positives = 112/250 (44%), Gaps = 62/250 (24%)
Query: 7 KYDLIREVGRGSYGVVYEAVIRKTSARVAVK---KIRCHAPENVELALREFWALSSIKSQ 63
KY + + +G G++ VV E + R T A+K K +C E+ L E L +K
Sbjct: 392 KYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEH--LIENEVSILRRVK-- 447
Query: 64 HPNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCD 123
HPN+I L E + +A L+ VM+
Sbjct: 448 HPNIIMLVE-----------------------------------EMETATELFLVMELVK 472
Query: 124 GGDMNEYLLSR-KPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDL 182
GGD+ + + S K + ++ + L++AL +LH I+HRD+KP+N+L+ + D
Sbjct: 473 GGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLV----CEYPDG 528
Query: 183 EPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPE-VWEGHYTAKADIF 241
+LK+ DFGL+ V L T CGT Y+APE + E Y K DI+
Sbjct: 529 TKSLKLGDFGLATVVEGP--------------LYTVCGTPTYVAPEIIAETGYGLKVDIW 574
Query: 242 ALGIIIWAML 251
A G+I + +L
Sbjct: 575 AAGVITYILL 584
>gi|156713428 doublecortin-like kinase 2 isoform a [Homo sapiens]
Length = 766
Score = 85.5 bits (210), Expect = 6e-17
Identities = 72/250 (28%), Positives = 112/250 (44%), Gaps = 62/250 (24%)
Query: 7 KYDLIREVGRGSYGVVYEAVIRKTSARVAVK---KIRCHAPENVELALREFWALSSIKSQ 63
KY + + +G G++ VV E + R T A+K K +C E+ L E L +K
Sbjct: 393 KYKIGKVIGDGNFAVVKECIDRSTGKEFALKIIDKAKCCGKEH--LIENEVSILRRVK-- 448
Query: 64 HPNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCD 123
HPN+I L E + +A L+ VM+
Sbjct: 449 HPNIIMLVE-----------------------------------EMETATELFLVMELVK 473
Query: 124 GGDMNEYLLSR-KPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDL 182
GGD+ + + S K + ++ + L++AL +LH I+HRD+KP+N+L+ + D
Sbjct: 474 GGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLV----CEYPDG 529
Query: 183 EPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPE-VWEGHYTAKADIF 241
+LK+ DFGL+ V L T CGT Y+APE + E Y K DI+
Sbjct: 530 TKSLKLGDFGLATVVEGP--------------LYTVCGTPTYVAPEIIAETGYGLKVDIW 575
Query: 242 ALGIIIWAML 251
A G+I + +L
Sbjct: 576 AAGVITYILL 585
>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
Length = 297
Score = 84.0 bits (206), Expect = 2e-16
Identities = 75/266 (28%), Positives = 120/266 (45%), Gaps = 74/266 (27%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPEN--VELALREFWALSSIKSQHP 65
Y I ++G G+YGVVY+ + T VA+KKIR + E A+RE L ++ HP
Sbjct: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR--HP 61
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
N++ L++ ++Q +S LYL S+
Sbjct: 62 NIVSLQDVLMQ------------DSRLYLIFEFLSM------------------------ 85
Query: 126 DMNEYLLSRKPNRKTNT----SFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSD 181
D+ +YL S P + ++ S++ Q+ + F H +++HRDLKP N+LI D
Sbjct: 86 DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLI--------D 137
Query: 182 LEPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKAD 239
+ T+K+ADFGL++ P+ V + T +Y +PEV G Y+ D
Sbjct: 138 DKGTIKLADFGLARAFGI-------PIRV----YTHEAITLWYRSPEVLLGSARYSTPVD 186
Query: 240 IFALGIIIWAMLERITFIDTETKKEL 265
I+++G I F + TKK L
Sbjct: 187 IWSIGTI---------FAELATKKPL 203
>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
Length = 297
Score = 84.0 bits (206), Expect = 2e-16
Identities = 75/266 (28%), Positives = 120/266 (45%), Gaps = 74/266 (27%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPEN--VELALREFWALSSIKSQHP 65
Y I ++G G+YGVVY+ + T VA+KKIR + E A+RE L ++ HP
Sbjct: 4 YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELR--HP 61
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
N++ L++ ++Q +S LYL S+
Sbjct: 62 NIVSLQDVLMQ------------DSRLYLIFEFLSM------------------------ 85
Query: 126 DMNEYLLSRKPNRKTNT----SFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSD 181
D+ +YL S P + ++ S++ Q+ + F H +++HRDLKP N+LI D
Sbjct: 86 DLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLI--------D 137
Query: 182 LEPTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKAD 239
+ T+K+ADFGL++ P+ V + T +Y +PEV G Y+ D
Sbjct: 138 DKGTIKLADFGLARAFGI-------PIRV----YTHEVVTLWYRSPEVLLGSARYSTPVD 186
Query: 240 IFALGIIIWAMLERITFIDTETKKEL 265
I+++G I F + TKK L
Sbjct: 187 IWSIGTI---------FAELATKKPL 203
>gi|193083129 MAP/microtubule affinity-regulating kinase 3 isoform d
[Homo sapiens]
Length = 713
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/310 (24%), Positives = 140/310 (45%), Gaps = 68/310 (21%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHA--PENVELALREFWALSSIKSQHP 65
Y L++ +G+G++ V A T VA+K I P +++ RE + + HP
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN--HP 113
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
N++ L E I + +LYL +M++ GG
Sbjct: 114 NIVKLFEVI------------ETEKTLYL-----------------------IMEYASGG 138
Query: 126 DMNEYLLSR-KPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEP 184
++ +YL++ + K S Q+ SA+ + H+ +I+HRDLK +N+L+ D +
Sbjct: 139 EVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLL--------DADM 190
Query: 185 TLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADIFA 242
+K+ADFG S + G+ L T CG+ Y APE+++G + + D+++
Sbjct: 191 NIKIADFGFSNEFTVGGK------------LDTFCGSPPYAAPELFQGKKYDGPEVDVWS 238
Query: 243 LGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLI--PVKKKSM 300
LG+I++ ++ D + KEL ++ I EN L+ P+K+
Sbjct: 239 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR--- 295
Query: 301 NGRMKQLIKE 310
G ++Q++K+
Sbjct: 296 -GTLEQIMKD 304
>gi|193083127 MAP/microtubule affinity-regulating kinase 3 isoform b
[Homo sapiens]
Length = 744
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/310 (24%), Positives = 140/310 (45%), Gaps = 68/310 (21%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHA--PENVELALREFWALSSIKSQHP 65
Y L++ +G+G++ V A T VA+K I P +++ RE + + HP
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN--HP 113
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
N++ L E I + +LYL +M++ GG
Sbjct: 114 NIVKLFEVI------------ETEKTLYL-----------------------IMEYASGG 138
Query: 126 DMNEYLLSR-KPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEP 184
++ +YL++ + K S Q+ SA+ + H+ +I+HRDLK +N+L+ D +
Sbjct: 139 EVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLL--------DADM 190
Query: 185 TLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADIFA 242
+K+ADFG S + G+ L T CG+ Y APE+++G + + D+++
Sbjct: 191 NIKIADFGFSNEFTVGGK------------LDTFCGSPPYAAPELFQGKKYDGPEVDVWS 238
Query: 243 LGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLI--PVKKKSM 300
LG+I++ ++ D + KEL ++ I EN L+ P+K+
Sbjct: 239 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR--- 295
Query: 301 NGRMKQLIKE 310
G ++Q++K+
Sbjct: 296 -GTLEQIMKD 304
>gi|193083125 MAP/microtubule affinity-regulating kinase 3 isoform a
[Homo sapiens]
Length = 753
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/310 (24%), Positives = 140/310 (45%), Gaps = 68/310 (21%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHA--PENVELALREFWALSSIKSQHP 65
Y L++ +G+G++ V A T VA+K I P +++ RE + + HP
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN--HP 113
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
N++ L E I + +LYL +M++ GG
Sbjct: 114 NIVKLFEVI------------ETEKTLYL-----------------------IMEYASGG 138
Query: 126 DMNEYLLSR-KPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEP 184
++ +YL++ + K S Q+ SA+ + H+ +I+HRDLK +N+L+ D +
Sbjct: 139 EVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLL--------DADM 190
Query: 185 TLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADIFA 242
+K+ADFG S + G+ L T CG+ Y APE+++G + + D+++
Sbjct: 191 NIKIADFGFSNEFTVGGK------------LDTFCGSPPYAAPELFQGKKYDGPEVDVWS 238
Query: 243 LGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLI--PVKKKSM 300
LG+I++ ++ D + KEL ++ I EN L+ P+K+
Sbjct: 239 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR--- 295
Query: 301 NGRMKQLIKE 310
G ++Q++K+
Sbjct: 296 -GTLEQIMKD 304
>gi|46852166 MAP/microtubule affinity-regulating kinase 3 isoform c
[Homo sapiens]
Length = 729
Score = 83.6 bits (205), Expect = 2e-16
Identities = 76/310 (24%), Positives = 140/310 (45%), Gaps = 68/310 (21%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHA--PENVELALREFWALSSIKSQHP 65
Y L++ +G+G++ V A T VA+K I P +++ RE + + HP
Sbjct: 56 YRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILN--HP 113
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
N++ L E I + +LYL +M++ GG
Sbjct: 114 NIVKLFEVI------------ETEKTLYL-----------------------IMEYASGG 138
Query: 126 DMNEYLLSR-KPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEP 184
++ +YL++ + K S Q+ SA+ + H+ +I+HRDLK +N+L+ D +
Sbjct: 139 EVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLL--------DADM 190
Query: 185 TLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADIFA 242
+K+ADFG S + G+ L T CG+ Y APE+++G + + D+++
Sbjct: 191 NIKIADFGFSNEFTVGGK------------LDTFCGSPPYAAPELFQGKKYDGPEVDVWS 238
Query: 243 LGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLI--PVKKKSM 300
LG+I++ ++ D + KEL ++ I EN L+ P+K+
Sbjct: 239 LGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKR--- 295
Query: 301 NGRMKQLIKE 310
G ++Q++K+
Sbjct: 296 -GTLEQIMKD 304
>gi|20986497 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 83.2 bits (204), Expect = 3e-16
Identities = 70/253 (27%), Positives = 119/253 (47%), Gaps = 54/253 (21%)
Query: 7 KYDLIREVGRGSYGVVYEAVIRKTSARVAVKKI--RCHAPENVELALREFWALSSIKSQH 64
+Y++I +G G+YGVV A R T +VA+KKI N + LRE L K H
Sbjct: 54 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK--H 111
Query: 65 PNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDG 124
N+I + KD + + +G S+Y+ V+D +
Sbjct: 112 DNIIAI------KDILRPTVPYGEFKSVYV-----------------------VLDLMES 142
Query: 125 GDMNEYLLSRKPNRKTNTSFML-QLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLE 183
D+++ + S +P + + L QL L ++H Q+IHRDLKP N+L+++
Sbjct: 143 -DLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNE--------N 193
Query: 184 PTLKVADFGLSK-VCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADI 240
LK+ DFG+++ +C++ + ++ F++ T +Y APE+ YT D+
Sbjct: 194 CELKIGDFGMARGLCTSPAE--------HQYFMTEYVATRWYRAPELMLSLHEYTQAIDL 245
Query: 241 FALGIIIWAMLER 253
+++G I ML R
Sbjct: 246 WSVGCIFGEMLAR 258
>gi|209529736 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 83.2 bits (204), Expect = 3e-16
Identities = 70/253 (27%), Positives = 119/253 (47%), Gaps = 54/253 (21%)
Query: 7 KYDLIREVGRGSYGVVYEAVIRKTSARVAVKKI--RCHAPENVELALREFWALSSIKSQH 64
+Y++I +G G+YGVV A R T +VA+KKI N + LRE L K H
Sbjct: 54 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK--H 111
Query: 65 PNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDG 124
N+I + KD + + +G S+Y+ V+D +
Sbjct: 112 DNIIAI------KDILRPTVPYGEFKSVYV-----------------------VLDLMES 142
Query: 125 GDMNEYLLSRKPNRKTNTSFML-QLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLE 183
D+++ + S +P + + L QL L ++H Q+IHRDLKP N+L+++
Sbjct: 143 -DLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNE--------N 193
Query: 184 PTLKVADFGLSK-VCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADI 240
LK+ DFG+++ +C++ + ++ F++ T +Y APE+ YT D+
Sbjct: 194 CELKIGDFGMARGLCTSPAE--------HQYFMTEYVATRWYRAPELMLSLHEYTQAIDL 245
Query: 241 FALGIIIWAMLER 253
+++G I ML R
Sbjct: 246 WSVGCIFGEMLAR 258
>gi|209529734 mitogen-activated protein kinase 7 isoform 1 [Homo
sapiens]
Length = 816
Score = 83.2 bits (204), Expect = 3e-16
Identities = 70/253 (27%), Positives = 119/253 (47%), Gaps = 54/253 (21%)
Query: 7 KYDLIREVGRGSYGVVYEAVIRKTSARVAVKKI--RCHAPENVELALREFWALSSIKSQH 64
+Y++I +G G+YGVV A R T +VA+KKI N + LRE L K H
Sbjct: 54 EYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFK--H 111
Query: 65 PNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDG 124
N+I + KD + + +G S+Y+ V+D +
Sbjct: 112 DNIIAI------KDILRPTVPYGEFKSVYV-----------------------VLDLMES 142
Query: 125 GDMNEYLLSRKPNRKTNTSFML-QLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLE 183
D+++ + S +P + + L QL L ++H Q+IHRDLKP N+L+++
Sbjct: 143 -DLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNE--------N 193
Query: 184 PTLKVADFGLSK-VCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADI 240
LK+ DFG+++ +C++ + ++ F++ T +Y APE+ YT D+
Sbjct: 194 CELKIGDFGMARGLCTSPAE--------HQYFMTEYVATRWYRAPELMLSLHEYTQAIDL 245
Query: 241 FALGIIIWAMLER 253
+++G I ML R
Sbjct: 246 WSVGCIFGEMLAR 258
>gi|24308326 BR serine/threonine kinase 1 [Homo sapiens]
Length = 778
Score = 83.2 bits (204), Expect = 3e-16
Identities = 75/276 (27%), Positives = 126/276 (45%), Gaps = 63/276 (22%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKI-RCHAPENVELAL-REFWALSSIKSQHP 65
Y L + +G+G G+V V T +VA+K + R E+V + + RE L I +HP
Sbjct: 34 YRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLI--EHP 91
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
+V+ L + K YL+ V++ GG
Sbjct: 92 HVLKLHDVYENKK-----------------------------------YLYLVLEHVSGG 116
Query: 126 DMNEYLLSR-KPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEP 184
++ +YL+ + + K F Q+ SAL F H I HRDLKP+N+L+ D +
Sbjct: 117 ELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLL--------DEKN 168
Query: 185 TLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADIFA 242
+++ADFG++ + V L T+CG+ Y PEV +G + +AD+++
Sbjct: 169 NIRIADFGMAS------------LQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWS 216
Query: 243 LGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVP 278
G+I++A+L D + ++LL VK+G +P
Sbjct: 217 CGVILFALLVGALPFDDDNLRQLL-EKVKRGVFHMP 251
>gi|166064027 cyclin-dependent kinase-like 3 isoform 1 [Homo
sapiens]
Length = 592
Score = 81.6 bits (200), Expect = 9e-16
Identities = 84/332 (25%), Positives = 146/332 (43%), Gaps = 69/332 (20%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENV-ELALREFWALSSIKSQHPN 66
Y+ + +VG GSYG V + + T VA+K ++V ++A+RE L H N
Sbjct: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQF--HHEN 61
Query: 67 VIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGD 126
+++L E QK K H L + ++ ++ E+ +C G
Sbjct: 62 LVNLIEVFRQK-----KKIH-----LVFEFIDHTVLDEL-------------QHYCHG-- 96
Query: 127 MNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPTL 186
L K RK ++ Q+ A+ +LH N IIHRD+KP+NIL+SQ+ +
Sbjct: 97 -----LESKRLRK----YLFQILRAIDYLHSNNIIHRDIKPENILVSQSGI--------T 139
Query: 187 KVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPE--VWEGHYTAKADIFALG 244
K+ DFG ++ +A G + V+ T +Y APE + + Y DI+ALG
Sbjct: 140 KLCDFGFARTLAAPGDIYTDYVA-----------TRWYRAPELVLKDTSYGKPVDIWALG 188
Query: 245 IIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLEN---------PKMELLIPV 295
+I M ++ + + +LL V + + P + + P+++
Sbjct: 189 CMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNA 248
Query: 296 KKK--SMNGRMKQLIKEMLAANPQDRPDAFEL 325
+KK +NG + ++ L +P DR + +L
Sbjct: 249 RKKYPKLNGLLADIVHACLQIDPADRISSSDL 280
>gi|166064025 cyclin-dependent kinase-like 3 isoform 2 [Homo
sapiens]
Length = 455
Score = 81.6 bits (200), Expect = 9e-16
Identities = 84/332 (25%), Positives = 146/332 (43%), Gaps = 69/332 (20%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENV-ELALREFWALSSIKSQHPN 66
Y+ + +VG GSYG V + + T VA+K ++V ++A+RE L H N
Sbjct: 4 YETLGKVGEGSYGTVMKCKHKNTGQIVAIKIFYERPEQSVNKIAMREIKFLKQF--HHEN 61
Query: 67 VIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGD 126
+++L E QK K H L + ++ ++ E+ +C G
Sbjct: 62 LVNLIEVFRQK-----KKIH-----LVFEFIDHTVLDEL-------------QHYCHG-- 96
Query: 127 MNEYLLSRKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPTL 186
L K RK ++ Q+ A+ +LH N IIHRD+KP+NIL+SQ+ +
Sbjct: 97 -----LESKRLRK----YLFQILRAIDYLHSNNIIHRDIKPENILVSQSGI--------T 139
Query: 187 KVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPE--VWEGHYTAKADIFALG 244
K+ DFG ++ +A G + V+ T +Y APE + + Y DI+ALG
Sbjct: 140 KLCDFGFARTLAAPGDIYTDYVA-----------TRWYRAPELVLKDTSYGKPVDIWALG 188
Query: 245 IIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLEN---------PKMELLIPV 295
+I M ++ + + +LL V + + P + + P+++
Sbjct: 189 CMIIEMATGNPYLPSSSDLDLLHKIVLKVGNLSPHLQNIFSKSPIFAGVVLPQVQHPKNA 248
Query: 296 KKK--SMNGRMKQLIKEMLAANPQDRPDAFEL 325
+KK +NG + ++ L +P DR + +L
Sbjct: 249 RKKYPKLNGLLADIVHACLQIDPADRISSSDL 280
>gi|7657214 hormonally upregulated Neu-associated kinase [Homo
sapiens]
Length = 714
Score = 81.6 bits (200), Expect = 9e-16
Identities = 65/242 (26%), Positives = 116/242 (47%), Gaps = 52/242 (21%)
Query: 12 REVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVELALREFWALSSIKSQHPNVIHLE 71
R++G GS+ V E + T +VA+K I + + A ++ + +
Sbjct: 66 RKLGEGSFAKVREGLHVLTGEKVAIKVI------DKKRAKKDTYVTKN------------ 107
Query: 72 ECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGDMNEYL 131
L+++G +Q+M N + L ++ET ++YYL VM+ C GG++ +
Sbjct: 108 ---LRREGQIQQMIRHPNITQLLDILET----------ENSYYL--VMELCPGGNLMHKI 152
Query: 132 LSRKPNRKTNT-SFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPTLKVAD 190
+K ++ ++ QL SA+ LH+ ++HRDLK +N+L+ D + +K+ D
Sbjct: 153 YEKKRLEESEARRYIRQLISAVEHLHRAGVVHRDLKIENLLL--------DEDNNIKLID 204
Query: 191 FGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVW-EGHYTAKADIFALGIIIWA 249
FGLS G + ST CG+ Y APE+ Y K D++++G+ ++A
Sbjct: 205 FGLSNCAGILGYSDP---------FSTQCGSPAYAAPELLARKKYGPKIDVWSIGVNMYA 255
Query: 250 ML 251
ML
Sbjct: 256 ML 257
>gi|33636756 MAP/microtubule affinity-regulating kinase 4 [Homo
sapiens]
Length = 688
Score = 80.5 bits (197), Expect = 2e-15
Identities = 70/264 (26%), Positives = 118/264 (44%), Gaps = 64/264 (24%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHA--PENVELALREFWALSSIKSQHP 65
Y L+R +G+G++ V A T VA+K I P +++ RE + + HP
Sbjct: 59 YRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLN--HP 116
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
N++ L E I + +LYL VM++ G
Sbjct: 117 NIVKLFEVI------------ETEKTLYL-----------------------VMEYASAG 141
Query: 126 DMNEYLLS--RKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLE 183
++ +YL+S R ++ F Q+ SA+ + H+ I+HRDLK +N+L+ D E
Sbjct: 142 EVFDYLVSHGRMKEKEARAKFR-QIVSAVHYCHQKNIVHRDLKAENLLL--------DAE 192
Query: 184 PTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADIF 241
+K+ADFG S + + L T CG+ Y APE+++G + + DI+
Sbjct: 193 ANIKIADFGFSNEFTLGSK------------LDTFCGSPPYAAPELFQGKKYDGPEVDIW 240
Query: 242 ALGIIIWAMLERITFIDTETKKEL 265
+LG+I++ ++ D KEL
Sbjct: 241 SLGVILYTLVSGSLPFDGHNLKEL 264
>gi|209364621 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform b [Homo sapiens]
Length = 360
Score = 80.1 bits (196), Expect = 3e-15
Identities = 76/271 (28%), Positives = 121/271 (44%), Gaps = 58/271 (21%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVE-LALREFWALSSIKSQHPN 66
Y++ +G G++ V A R ++ VA+K I A E L E L I HPN
Sbjct: 32 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRIS--HPN 89
Query: 67 VIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGD 126
++ LE+ H S S LYL M+ GG+
Sbjct: 90 IVALEDV------------HESPSHLYL-----------------------AMELVTGGE 114
Query: 127 MNEYLLSRKPNRKTNTSFML-QLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPT 185
+ + ++ R + + S ++ Q+ A+++LH I+HRDLKP+N+L + D+
Sbjct: 115 LFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSK----- 169
Query: 186 LKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKA-DIFALG 244
+ V+DFGLSK+ + + L TACGT Y+APE+ E KA D++ALG
Sbjct: 170 IMVSDFGLSKIQAGN-------------MLGTACGTPGYVAPELLEQKPYGKAVDVWALG 216
Query: 245 IIIWAMLERITFIDTETKKELLGSYVKQGTE 275
+I + +L E+ EL ++ E
Sbjct: 217 VISYILLCGYPPFYDESDPELFSQILRASYE 247
>gi|209364619 pregnancy upregulated non-ubiquitously expressed CaM
kinase isoform a [Homo sapiens]
Length = 426
Score = 80.1 bits (196), Expect = 3e-15
Identities = 76/271 (28%), Positives = 121/271 (44%), Gaps = 58/271 (21%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVE-LALREFWALSSIKSQHPN 66
Y++ +G G++ V A R ++ VA+K I A E L E L I HPN
Sbjct: 98 YEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRIS--HPN 155
Query: 67 VIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGD 126
++ LE+ H S S LYL M+ GG+
Sbjct: 156 IVALEDV------------HESPSHLYL-----------------------AMELVTGGE 180
Query: 127 MNEYLLSRKPNRKTNTSFML-QLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPT 185
+ + ++ R + + S ++ Q+ A+++LH I+HRDLKP+N+L + D+
Sbjct: 181 LFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSK----- 235
Query: 186 LKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEGHYTAKA-DIFALG 244
+ V+DFGLSK+ + + L TACGT Y+APE+ E KA D++ALG
Sbjct: 236 IMVSDFGLSKIQAGN-------------MLGTACGTPGYVAPELLEQKPYGKAVDVWALG 282
Query: 245 IIIWAMLERITFIDTETKKELLGSYVKQGTE 275
+I + +L E+ EL ++ E
Sbjct: 283 VISYILLCGYPPFYDESDPELFSQILRASYE 313
>gi|149589021 doublecortin-like kinase 3 [Homo sapiens]
Length = 648
Score = 80.1 bits (196), Expect = 3e-15
Identities = 64/247 (25%), Positives = 113/247 (45%), Gaps = 58/247 (23%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKI-RCHAPENVELALREFWALSSIKSQHPN 66
Y+ R +G G++ VV E R+T A+K I + ++ E + S+ HPN
Sbjct: 356 YETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLS--HPN 413
Query: 67 VIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGD 126
++ L E + ET ++ ++ ++++ GGD
Sbjct: 414 IVKLHE-----------------------VYETDME------------IYLILEYVQGGD 438
Query: 127 MNEYLLSRKPNRKTNTSFMLQ-LSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPT 185
+ + ++ + + + M+ L AL +H I+HRDLKP+N+L+ + D T
Sbjct: 439 LFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVHRDLKPENLLVQR----NEDKSTT 494
Query: 186 LKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVW-EGHYTAKADIFALG 244
LK+ADFGL+K + P+ T CGT Y+APE+ E Y + D++A G
Sbjct: 495 LKLADFGLAK-------HVVRPI-------FTVCGTPTYVAPEILSEKGYGLEVDMWAAG 540
Query: 245 IIIWAML 251
+I++ +L
Sbjct: 541 VILYILL 547
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 79.7 bits (195), Expect = 3e-15
Identities = 78/306 (25%), Positives = 136/306 (44%), Gaps = 66/306 (21%)
Query: 8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHA--PENVELALREFWALSSIKSQHP 65
Y L + +G+G++ V A T VAVK I P +++ RE + + HP
Sbjct: 60 YRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILN--HP 117
Query: 66 NVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125
N++ L E I + +LYL VM++ GG
Sbjct: 118 NIVKLFEVI------------ETEKTLYL-----------------------VMEYASGG 142
Query: 126 DMNEYLLS--RKPNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLE 183
++ +YL++ R ++ F Q+ SA+ + H+ I+HRDLK +N+L+ D +
Sbjct: 143 EVFDYLVAHGRMKEKEARAKFR-QIVSAVQYCHQKYIVHRDLKAENLLL--------DGD 193
Query: 184 PTLKVADFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEVWEG--HYTAKADIF 241
+K+ADFG S + + L T CG+ Y APE+++G + + D++
Sbjct: 194 MNIKIADFGFSNEFTVGNK------------LDTFCGSPPYAAPELFQGKKYDGPEVDVW 241
Query: 242 ALGIIIWAMLERITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLI--PVKKKS 299
+LG+I++ ++ D + KEL ++ I EN +LL+ P+K+ S
Sbjct: 242 SLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKLLVLNPIKRGS 301
Query: 300 MNGRMK 305
+ MK
Sbjct: 302 LEQIMK 307
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,271,973
Number of Sequences: 37866
Number of extensions: 497148
Number of successful extensions: 3274
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 563
Number of HSP's successfully gapped in prelim test: 228
Number of HSP's that attempted gapping in prelim test: 1289
Number of HSP's gapped (non-prelim): 1276
length of query: 341
length of database: 18,247,518
effective HSP length: 103
effective length of query: 238
effective length of database: 14,347,320
effective search space: 3414662160
effective search space used: 3414662160
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.