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Search of human proteins with 226442729
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|226442729 kelch-like 15 [Homo sapiens]
(604 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|226442729 kelch-like 15 [Homo sapiens] 1245 0.0
gi|45643138 kelch-like 13 [Homo sapiens] 311 1e-84
gi|24308181 kelch-like 9 [Homo sapiens] 311 1e-84
gi|8922854 kelch-like 26 [Homo sapiens] 288 8e-78
gi|24432026 kelch-like [Homo sapiens] 265 9e-71
gi|31542246 kelch-like 36 [Homo sapiens] 247 3e-65
gi|156616301 kelch-like 32 [Homo sapiens] 241 1e-63
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 234 1e-61
gi|55741643 kelch-like 14 [Homo sapiens] 223 4e-58
gi|23397572 kelch-like 34 [Homo sapiens] 206 4e-53
gi|55925604 kelch-like 18 [Homo sapiens] 187 2e-47
gi|40807500 kelch-like 20 [Homo sapiens] 187 3e-47
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 186 7e-47
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 186 7e-47
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 183 3e-46
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 183 3e-46
gi|148664209 kelch-like 10 [Homo sapiens] 182 8e-46
gi|109150407 kelch-like 6 [Homo sapiens] 178 1e-44
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 176 4e-44
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 176 4e-44
gi|11056006 kelch-like 12 [Homo sapiens] 172 6e-43
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 172 8e-43
gi|14780904 kelch-like 1 protein [Homo sapiens] 172 1e-42
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 171 2e-42
gi|34101268 kelch-like 8 [Homo sapiens] 171 2e-42
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 170 3e-42
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 170 3e-42
gi|166235129 kelch-like 3 [Homo sapiens] 163 4e-40
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 160 4e-39
gi|38194229 kelch-like 17 [Homo sapiens] 158 2e-38
>gi|226442729 kelch-like 15 [Homo sapiens]
Length = 604
Score = 1245 bits (3221), Expect = 0.0
Identities = 604/604 (100%), Positives = 604/604 (100%)
Query: 1 MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMF 60
MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMF
Sbjct: 1 MAGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMF 60
Query: 61 TADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFC 120
TADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFC
Sbjct: 61 TADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFC 120
Query: 121 CSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKL 180
CSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKL
Sbjct: 121 CSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKL 180
Query: 181 MSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSE 240
MSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSE
Sbjct: 181 MSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSE 240
Query: 241 FYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILL 300
FYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILL
Sbjct: 241 FYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILL 300
Query: 301 LKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWL 360
LKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWL
Sbjct: 301 LKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWL 360
Query: 361 QMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHE 420
QMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHE
Sbjct: 361 QMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHE 420
Query: 421 GTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCF 480
GTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCF
Sbjct: 421 GTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCF 480
Query: 481 HKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVL 540
HKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVL
Sbjct: 481 HKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVL 540
Query: 541 DKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEV 600
DKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEV
Sbjct: 541 DKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEV 600
Query: 601 RRCN 604
RRCN
Sbjct: 601 RRCN 604
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 311 bits (796), Expect = 1e-84
Identities = 191/594 (32%), Positives = 309/594 (52%), Gaps = 27/594 (4%)
Query: 2 AGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVI--EDHQFQAHKALLATQSDYFRIM 59
AG F S+ H + V GF L EGLL DVTL+ D F H+ ++A+ SDYF+ M
Sbjct: 63 AGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAM 122
Query: 60 FTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKF 119
FT M+E+D I L G++ G ++ F+Y + L+M+ + + L+AA ++Q++ V+ F
Sbjct: 123 FTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDF 182
Query: 120 CCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEK 179
C FL++ + L+NC E+ R+ + + N+ V + +++F+L NF L+S +FL L FE+
Sbjct: 183 CKVFLISGVTLDNCVEVGRIANTY--NLTEVDKYVNSFVLKNFPALLSTGEFLK-LPFER 239
Query: 180 LMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTS 239
L L ++ L E+EL++A WLR + R +++NIRF LMTP + V+T
Sbjct: 240 LAFVLSSNSLKHCTELELFKATCRWLRLEEPRMDFAAKLMKNIRFPLMTPQELINYVQTV 299
Query: 240 EFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKIL 299
+F R + +A NY + QP++ + IRS G++ +V SK L
Sbjct: 300 DFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKEL 359
Query: 300 LL--KKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQN 357
+ +K W L P +A++ NF++++GG+ A VFR+DPR N
Sbjct: 360 RMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYN 419
Query: 358 SWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKY 417
W+Q+A ++ R+ F + + ++YAV GR + E Y+ ++W +V Y
Sbjct: 420 KWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHY 479
Query: 418 GHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYA 477
GH GTV ++I+GGIT + K++ FDP T+ W K+ M
Sbjct: 480 GHAGTVYGGVMYISGGITHDTFQKELMCFDPD---------------TDKWIQKAPMTTV 524
Query: 478 RCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGV 537
R H M + +LYV GG R + + S E Y+P DQWT +A+M G+S GV
Sbjct: 525 RGLHCMCTVGERLYVIGG--NHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582
Query: 538 TVLDKQIMVLGGLCYNGHYSDSIL-TFDPDENKWKEDEYPRMPCKLDGLQVCNL 590
V + +I V+GG +N I+ +DPD+++W + +P L G++ C L
Sbjct: 583 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW--HKVFDLPESLGGIRACTL 634
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 311 bits (796), Expect = 1e-84
Identities = 191/594 (32%), Positives = 309/594 (52%), Gaps = 27/594 (4%)
Query: 2 AGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQ--FQAHKALLATQSDYFRIM 59
AG F S+ H + V GF L EGLL DVTLV D F H+A++A+ SDYF+ M
Sbjct: 21 AGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDYFKAM 80
Query: 60 FTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKF 119
FT M+E+D I L G+ G ++ F+Y + L+M+ + + L+AA ++Q++ V+ F
Sbjct: 81 FTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDF 140
Query: 120 CCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEK 179
C FL++ + L+NC E+ R+ + + N+ V + ++ F+L NF L+S +FL L FE+
Sbjct: 141 CKVFLISGVSLDNCVEVGRIANTY--NLIEVDKYVNNFILKNFPALLSTGEFLK-LPFER 197
Query: 180 LMSYLDNDHLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTS 239
L L ++ L E+EL++A WLR + R + +++NIRF LMTP + V+T
Sbjct: 198 LAFVLSSNSLKHCTELELFKAACRWLRLEDPRMDYAAKLMKNIRFPLMTPQDLINYVQTV 257
Query: 240 EFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKIL 299
+F R + +A NY + QP++ + IRS G++ +V SK L
Sbjct: 258 DFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQLVVSKEL 317
Query: 300 LL--KKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQN 357
+ ++ + W L P +A++ NF++++GG+ A VFR+DPR N
Sbjct: 318 RMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYN 377
Query: 358 SWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKY 417
W+Q+A ++ R+ F + + +YAV GR+ + E Y+ ++W +V Y
Sbjct: 378 KWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHY 437
Query: 418 GHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYA 477
GH GTV ++I+GGIT + ++ FDP T+ W K+ M
Sbjct: 438 GHAGTVYGGLMYISGGITHDTFQNELMCFDPD---------------TDKWMQKAPMTTV 482
Query: 478 RCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGV 537
R H M + KLYV GG R + + S E Y+P DQWT +A+M G+S GV
Sbjct: 483 RGLHCMCTVGDKLYVIGG--NHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGV 540
Query: 538 TVLDKQIMVLGGLCYNGHYSDSIL-TFDPDENKWKEDEYPRMPCKLDGLQVCNL 590
V + +I V+GG +N I+ +DP++++W + +P L G++ C L
Sbjct: 541 AVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW--HKVFDLPESLGGIRACTL 592
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 288 bits (738), Expect = 8e-78
Identities = 181/575 (31%), Positives = 288/575 (50%), Gaps = 32/575 (5%)
Query: 8 FCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRER 67
F + H TS+ G L +G LLDV L I F AHK +LA SDYFR MFT MRE
Sbjct: 40 FSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREA 99
Query: 68 DQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAK 127
QD I LKG++A G H++ F Y + L ++ V ++L AA+++Q++ VV+ C FL A
Sbjct: 100 SQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAA 159
Query: 128 ICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDND 187
+ +E C I ++ F ++ +RE +D F +F+ + DFL L E+L+ +L ++
Sbjct: 160 MSVETCLNIGQMATTF--SLASLRESVDAFTFRHFLQIAEEEDFLR-LPLERLVFFLQSN 216
Query: 188 HLSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQ 247
L EI+L+ A WL+HD R ++ +IRF LM + + + V+T +
Sbjct: 217 RLQSCAEIDLFRAAVRWLQHDPARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVL 276
Query: 248 LRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRG---MIGHSMVNSKILLLKKP 304
R + +A NY +Q + + +RS P F G V+SK+ L +P
Sbjct: 277 CRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEP 336
Query: 305 --RVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQM 362
R + EL +V C+A+++NFV++ GG+ L A +RYDP N WL++
Sbjct: 337 GARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRL 396
Query: 363 ADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGT 422
M R +F + V+ +YA GR R + S ERY ++W + +GH G
Sbjct: 397 QAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNEWGYACSLKRRTWGHAGA 456
Query: 423 VLNNKLFITGGI-TSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFH 481
+L+I+GG S K + +DP V + WE K+ M+ R H
Sbjct: 457 ASGGRLYISGGYGISVEDKKALHCYDP---------------VADQWEFKAPMSEPRVLH 501
Query: 482 KMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLD 541
M+ G++Y GG + F+ + E Y PETDQWT ++ M G+S G +L+
Sbjct: 502 AMVGAGGRIYALGGRMDHVDRCFD---VLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLE 558
Query: 542 KQIMVLGGLCYN---GHYSDSILTFDPDENKWKED 573
++I ++GG YN + + + ++ D ++W+ D
Sbjct: 559 RKIYIVGG--YNWRLNNVTGIVQVYNTDTDEWERD 591
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 265 bits (677), Expect = 9e-71
Identities = 186/609 (30%), Positives = 291/609 (47%), Gaps = 50/609 (8%)
Query: 10 SSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQ 69
S+ H ++ G AL + G+L DV LV+E +AH+ LLA DYFR MF ++E +Q
Sbjct: 29 SAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMFAGGLKEMEQ 88
Query: 70 DKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKIC 129
+++ + G++ +L F+Y +ELS++ V E L AA +Q+ E++ FCC FL++ +
Sbjct: 89 EEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFCCDFLMSWVD 148
Query: 130 LENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHL 189
EN ++ RL + F ++ + E+LDT++L NFV SR D L EK+ S L ++ L
Sbjct: 149 EENILDVYRLAELF--DLSRLTEQLDTYILKNFV-AFSRTDKYRQLPLEKVYSLLSSNRL 205
Query: 190 SRFPEIELYEAVQSW------LRHDRRRWRHTDTIIQNIRFCLMTP---TSVFEKVKTSE 240
E E+YE + ++ D+ +++ +RF LM + +K+ S
Sbjct: 206 EVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHDKLDPS- 264
Query: 241 FYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIG-HSMVNSKIL 299
LR V AL Y +N QP L + +RS F G+ S V S
Sbjct: 265 ------PLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPSTVLSDQA 318
Query: 300 LLKKPRV--WWELEGPQVP-LRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQ 356
P + W P + +A++NNFV+L+GG+ G F A S+ +RYDPR
Sbjct: 319 KYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDN-NVQG-FRAESRCWRYDPRH 376
Query: 357 NSWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNK 416
N W Q+ + ++ +V V+G++IYAVAGR + ERYD + W +V P
Sbjct: 377 NRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNSWAYVAPLKREV 436
Query: 417 YGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNY 476
Y H G L K++IT G K+ +DP +N W +
Sbjct: 437 YAHAGATLEGKMYITCGRRGEDYLKETHCYDPG---------------SNTWHTLADGPV 481
Query: 477 ARCFHKMISYNGKLYVFGGV--CVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSG 534
R +H M + KLYV GG R C Y+ + QW+ + +P G
Sbjct: 482 RRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVAC-----YSCTSGQWSSVCPLPAGHGE 536
Query: 535 HGVTVLDKQIMVLGGLCYN-GHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFP 593
G+ VLD +I VLGG +N G + + +D +++ W+E P++ + GL C L P
Sbjct: 537 PGIAVLDNRIYVLGGRSHNRGSRTGYVHIYDVEKDCWEEG--PQLDNSISGLAACVLTLP 594
Query: 594 DYVLDEVRR 602
+L E R
Sbjct: 595 RSLLLEPPR 603
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 247 bits (630), Expect = 3e-65
Identities = 162/567 (28%), Positives = 269/567 (47%), Gaps = 28/567 (4%)
Query: 13 HDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKI 72
H ++V GL DV LV ++ + AH+ LLA SDYF MFT MRE Q ++
Sbjct: 28 HSSTVLQRLNEQRLRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAFQKEV 87
Query: 73 HLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLEN 132
L G + G V+ F+Y G + L + +L+ A +Q+ VV FCC +L ++ +N
Sbjct: 88 ELIGASYIGLKAVVDFLYGGELVLDGGNIDYVLETAHLLQIWTVVDFCCEYLEQEVSEDN 147
Query: 133 CAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRF 192
+ L + +++ + +D F+L++F L PDFL +S +KL YL + + R
Sbjct: 148 YLYLQELASIY--SLKRLDAFIDGFILNHFGTLSFTPDFLQNVSMQKLCVYLSSSEVQRE 205
Query: 193 PEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYE- 251
E +L +A WL R H +++NI F L+ + +VK + ++ E
Sbjct: 206 CEHDLLQAALQWLTQQPEREAHARQVLENIHFPLIPKNDLLHRVKPAVCSLLPKEANCEG 265
Query: 252 -VDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMV--NSKILLLKKPRVWW 308
+++A+ Y N+ QP++ K + +R+ + + G + + + L W
Sbjct: 266 FIEEAVRYHNNLAAQPVMQTKRTALRTNQERLLFVGGEVSERCLELSDDTCYLDAKSEQW 325
Query: 309 ELEGPQVPLRPD--CLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMS 366
E P +P R C+A++ F+F+ GG +G AS+ ++RYDPR W+++A M+
Sbjct: 326 VKETP-LPARRSHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVASMN 384
Query: 367 VPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNN 426
R +F + I + A+ GR + S E Y D W +V P YGH GT+ +
Sbjct: 385 QRRVDFYLASIEDMLVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTYGHAGTIYKD 444
Query: 427 KLFITGG--ITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMI 484
++I+GG K + +D RT V WE + M AR +H M
Sbjct: 445 FVYISGGHDYQIGPYRKNLLCYD-----------HRTDV----WEERRPMTTARGWHSMC 489
Query: 485 SYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQI 544
S +Y GG + S E E Y+P+ +QWT +A + S GV V + +I
Sbjct: 490 SLGDSIYSIGGSDDNIE-SMERFDVLGVEAYSPQCNQWTRVAPLLHANSESGVAVWEGRI 548
Query: 545 MVLGGLCY-NGHYSDSILTFDPDENKW 570
+LGG + N +S ++ +D + +KW
Sbjct: 549 YILGGYSWENTAFSKTVQVYDREADKW 575
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 241 bits (615), Expect = 1e-63
Identities = 169/600 (28%), Positives = 296/600 (49%), Gaps = 36/600 (6%)
Query: 10 SSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQ 69
S H+ SV A +G+L D+TL+ E+ +F AHKA+LA SDYFR MF+ M E
Sbjct: 21 SESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGA 80
Query: 70 DKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKIC 129
D+++L G+T+ G L+F Y G I L + ++L A ++QL+E++ C +L+ ++
Sbjct: 81 DEVNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQELN 140
Query: 130 LENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLM-SRPDFLSYLSFEKLMSYLDNDH 188
N ++ RL D F N+ + + + FL+ + L+ SRP+ + L + L L +D
Sbjct: 141 SFNYLDLYRLADLF--NLTLLEKAVIDFLVKHLSELLKSRPEEVLTLPYCLLQEVLKSDR 198
Query: 189 LSRFPEIELYEAVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQL 248
L+ E ++++ WL H+ +++ D ++Q IRF LM ++ + + S
Sbjct: 199 LTSLSEEQIWQLAVRWLEHN-CHYQYMDELLQYIRFGLMDVDTLHTVALSHPLVQASETA 257
Query: 249 RYEVDQALNYFQNVHQQPLLDMKSSR----------IRSAKPQTTVFRGMIGHSMVNSKI 298
V++AL Y Q+++ QP+ + ++ I K + + + + V+ +
Sbjct: 258 TALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELRYFNPVDQEN 317
Query: 299 LLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNS 358
L+ W EL V C+A++ +F+F+ GGE G A RYDPR NS
Sbjct: 318 ALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTACRYDPRSNS 377
Query: 359 WLQMADMSVPRSEFAVGVIGKFIYAVAGRTR-DETFYSTERYDITNDKWEFVDPYPVNKY 417
W ++A M R F +G + +++YAV GR + + ERY +KW FV + +
Sbjct: 378 WAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLS 437
Query: 418 GHEGTVLNNKLFITGGITSSST-SKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNY 476
H G V + L+I+GG+T+++ ++ V++P++ N W ++S M
Sbjct: 438 CHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQ---------------NKWISRSPMLQ 482
Query: 477 ARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWT-ILASMPIGRSGH 535
R +H M + KLYV GG L + + + YN +TDQWT ++ G++
Sbjct: 483 RRVYHSMAAVQRKLYVLGG--NDLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNES 540
Query: 536 GVTVLDKQIMVLGGLCYNGHYSDSILTFDPDENKWKEDEY--PRMPCKLDGLQVCNLHFP 593
GV V + +I ++GG + + + + KE+ + P +P +G+ C L P
Sbjct: 541 GVAVHNGRIYLVGGYSIWTNEPLACIQVLDVSREGKEEVFYGPTLPFASNGIAACFLPAP 600
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 234 bits (598), Expect = 1e-61
Identities = 149/588 (25%), Positives = 284/588 (48%), Gaps = 32/588 (5%)
Query: 20 GFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTA 79
G + +E L D+ + + F HK+++A+ S+YF + ++ ++ L ++
Sbjct: 62 GLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYF---YNILKKDPSIQRVDLNDISP 118
Query: 80 TGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRL 139
G + V+ + Y G + LS+ T+ I+ AA+Y+Q+ +VK C FL+ ++ +ENC ++ +
Sbjct: 119 LGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDFLIREMSVENCMYVVNI 178
Query: 140 LDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYE 199
+ + +++ + F+ DNF+ F+ L+FE++ L +D L EI ++
Sbjct: 179 AETY--SLKNAKAAAQKFIRDNFLEFAESDQFMK-LTFEQINELLIDDDLQLPSEIVAFQ 235
Query: 200 AVQSWLRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYF 259
WL D++R ++ ++ NIRF ++ + V++ + A+NY
Sbjct: 236 IAMKWLEFDQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRMMQDADCHRLLVDAMNYH 295
Query: 260 QNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVN-SKILLLKKPRVWWELEGPQVPLR 318
+ Q L + +RIR G G + + S+ +L + P W + ++P +
Sbjct: 296 LLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPENGWS-KLTEMPAK 354
Query: 319 P--DCLAIVNNFVFLLGGEELGP--DGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAV 374
C+A+++ F+++ GGE+ + HA S RYDPR N+W+ +A M+ R+ F++
Sbjct: 355 SFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRFNTWIHLASMNQKRTHFSL 414
Query: 375 GVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGI 434
V +YA GR + + S E Y + ++W+ P V + H V + ++ +TGG
Sbjct: 415 SVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGY 474
Query: 435 TSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFG 494
+++ S+ VC +DP+ + W+ ++ R +H ++ + ++YV G
Sbjct: 475 IANAYSRSVCAYDPASDS---------------WQELPNLSTPRGWHCAVTLSDRVYVMG 519
Query: 495 GVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCY-N 553
G + R E + E Y+P T QW+ A + +G S GV+ L + ++GG
Sbjct: 520 GSQLGPRG--ERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGE 577
Query: 554 GHYSDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDEVR 601
Y I F P+ N+W ED+ +P G+ C L P+ V E R
Sbjct: 578 KKYKKCIQCFSPELNEWTEDD--ELPEATVGVSCCTLSMPNNVTRESR 623
>gi|55741643 kelch-like 14 [Homo sapiens]
Length = 628
Score = 223 bits (568), Expect = 4e-58
Identities = 167/632 (26%), Positives = 286/632 (45%), Gaps = 91/632 (14%)
Query: 2 AGDVEGFCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFT 61
+GD H ++ G L+ + L DVTL + QF HKA+LA+ S YFR +F+
Sbjct: 4 SGDRTSTFDPSHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS 63
Query: 62 A------------------DMRERDQDK-------------------------------- 71
+ D ++ Q +
Sbjct: 64 SHPPLGGGVGGQDGLGAPKDQQQPPQQQPSQQQQPPPQEEPGTPSSSPDDKLLTSPRAIN 123
Query: 72 -IHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICL 130
+ L+G ++ G VL+++Y + LS++TV E+L + + + +V K C FL +I +
Sbjct: 124 NLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISV 183
Query: 131 ENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLS 190
+N ++ ++ G +E ++ + +L+++ + L+FE++ + LD+
Sbjct: 184 QNYKQVCKIAALHG--LEETKKLANKYLVEDVL----------LLNFEEMRALLDSLPPP 231
Query: 191 RFPEIELYEAVQSWLRHDRR-RWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLR 249
E+ L++ WL HDR R ++ +++ +RF L+ + E+V++ +F R +
Sbjct: 232 VESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVDFMRTDPVCQ 291
Query: 250 YEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMI-GHSMVNSKILLL--KKPRV 306
+ A+NY +Q +SRIRS K + G+ G + S ++ + +
Sbjct: 292 KLLLDAMNYHLMPFRQHCRQSLASRIRSNKKMLLLVGGLPPGPDRLPSNLVQYYDDEKKT 351
Query: 307 WWELEGPQVPLRPDCLAIVNNFVFLLGGEEL-GPDGEFHASSKVFRYDPRQNSWLQMADM 365
W L C+ V NF+F+LGGE+ P+G+ H+++ V RYDPR NSW+Q+ M
Sbjct: 352 WKILTIMPYNSAHHCVVEVENFLFVLGGEDQWNPNGK-HSTNFVSRYDPRFNSWIQLPPM 410
Query: 366 SVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLN 425
R+ F + K +Y + GR S E Y++ ++W +V P H G V N
Sbjct: 411 QERRASFYACRLDKHLYVIGGRNETGYLSSVECYNLETNEWRYVSSLPQPLAAHAGAVHN 470
Query: 426 NKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMIS 485
K++I+GG+ + + +DP V + W K MN R H +
Sbjct: 471 GKIYISGGVHNGEYVPWLYCYDP---------------VMDVWARKQDMNTKRAIHTLAV 515
Query: 486 YNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPI--GRSGHGVTVLDKQ 543
N +LY GG + F E Y+P+ DQW IL + PI GRSG G VLD
Sbjct: 516 MNDRLYAIGGNHL---KGFSHLDVMLVECYDPKGDQWNILQT-PILEGRSGPGCAVLDDS 571
Query: 544 IMVLGGLCYN-GHYSDSILTFDPDENKWKEDE 574
I ++GG ++ G Y S + + P++ W E E
Sbjct: 572 IYLVGGYSWSMGAYKSSTICYCPEKGTWTELE 603
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 206 bits (525), Expect = 4e-53
Identities = 174/650 (26%), Positives = 284/650 (43%), Gaps = 84/650 (12%)
Query: 8 FCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRER 67
+C + H ++ G++AL EG L DVTL E +F AH++LLA SDYFR +F + +E
Sbjct: 7 YCKA-HGGALLTGYQALRAEGFLCDVTLETEGSEFPAHRSLLACSSDYFRALFKSHTQES 65
Query: 68 DQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAK 127
IHL +A G +L F+Y + LSM+TV + L+AA Y+Q+ E + C +L +
Sbjct: 66 RARVIHLHVPSAAGLQRLLDFIYTAWLSLSMDTVEDTLEAASYLQVTEALGLCGRYLERQ 125
Query: 128 ICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSR---PDFLSYLSFEKLMSYL 184
+ ENC + FG + + + ++ + L++R P L L+ L + L
Sbjct: 126 LAPENCCFAANVAARFG--LAHTLDAAERCIVSHLQELLARGAGPAGLLELNPTSLRAVL 183
Query: 185 DNDHLSRFPEIELYEAVQSWLRHD--RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFY 242
++R PE L +WLR + R H +++ +RF L+ P V +V +
Sbjct: 184 GAPDVARVPEARLLGLALAWLRQEPTTERLAHCTELLERVRFGLV-PADVLRRVYSGSGL 242
Query: 243 RYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKI---- 298
+++ + QALNY +QPL+ + + IRS + + + G +V ++
Sbjct: 243 VLPARVKGLIIQALNYHTTPSRQPLMQGEQTSIRSPQTRILLVGGRRAREVVIEEVAAPQ 302
Query: 299 ------------------LLLKKPRVWWELEGPQV-----------------PLRPDCLA 323
L ++ WEL V PL +
Sbjct: 303 RAARGQVAAPEPEEEEEELEEEEEEEEWELTQNVVAFDVYNHRWRSLTQLPTPLLGHSVC 362
Query: 324 IVNNFVFLLGGEELGPDGEFHA---------SSKVFRYDPRQNSWLQMADMSVPRSEFAV 374
NF+F+LGGE P G + +++V RYDPR ++W ++ M R+ F
Sbjct: 363 TAGNFLFVLGGE--SPSGSASSPLADDSRVVTAQVHRYDPRFHAWTEVPAMREARAHFWC 420
Query: 375 GVIGKFIYAVAG-RTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLN-NKLFITG 432
G +G+ + AV G E S E YD+ D+W P +GH G V + ++I+G
Sbjct: 421 GAVGERLLAVGGLGAGGEVLASVEMYDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISG 480
Query: 433 GITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYV 492
G + D G EQ W K+ M AR H M G ++
Sbjct: 481 GKAGRGEGGASSLRDLYVLGPEEQ----------VWSKKAPMGTARFGHHMAVLRGAVFA 530
Query: 493 FGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCY 552
F G + E Y+P DQWT L +P R +G+ V+++ ++LGGL +
Sbjct: 531 FLG---------RYEPFSEIERYDPGADQWTRLRPLPYDRFCYGLAVVEETALLLGGLKW 581
Query: 553 NGHY---SDSILTFDPDENKWKEDEYPRMPCKLDGLQVCNLHFPDYVLDE 599
+ +++ +D D ++W ED +P GL+ L + DE
Sbjct: 582 RDSRQVPTRNVVGYDLDLDRW-EDIGCALPWAWSGLRCAVLQLAEGGDDE 630
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 187 bits (475), Expect = 2e-47
Identities = 143/563 (25%), Positives = 256/563 (45%), Gaps = 43/563 (7%)
Query: 18 SAGFRALYE---EGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHL 74
S G+ + E +G L DVTL I DH+F AH+ +LA YF MFT DM E QD+I +
Sbjct: 22 SRGYGVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVM 81
Query: 75 KGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCA 134
+G+ + ++ F Y G + + V +L A ++QL + CC+FL ++ +NC
Sbjct: 82 QGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCL 141
Query: 135 EIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPE 194
+ + + + + + ++F+ +FV + +FL+ L E ++ + D L+ E
Sbjct: 142 GVRQFAETMMCAV--LYDAANSFIHQHFVEVSMSEEFLA-LPLEDVLELVSRDELNVKSE 198
Query: 195 IELYEAVQSWLRHDR-RRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVD 253
+++EA +W+R+DR +R + ++ NIR L P + ++V+ + R + R VD
Sbjct: 199 EQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVD 258
Query: 254 QALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLK---KPRVWWEL 310
+A +Y ++P L +R R + + G + + +++ WE
Sbjct: 259 EAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWER 318
Query: 311 EGPQVPLRPDC-LAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPR 369
P R +A+VN ++ +GG DG+ S+ V Y+P ++W ++ M+ R
Sbjct: 319 CRPMTTARSRVGVAVVNGLLYAIGGY----DGQLRLST-VEAYNPETDTWTRVGSMNSKR 373
Query: 370 SEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLF 429
S V+ IY G + + S E Y DKW V N+ TV +++
Sbjct: 374 SAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIY 433
Query: 430 ITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGK 489
++GG + +F ++E T W + M RC H S K
Sbjct: 434 VSGG------HDGLQIF-----SSVEHYNHHTAT----WHPAAGMLNKRCRHGAASLGSK 478
Query: 490 LYVFGGVCVILRASFESQGCPS-TEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLG 548
++V GG ++ G S E+Y+ DQW ++ M RS + ++ +G
Sbjct: 479 MFVCGG--------YDGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVG 530
Query: 549 GLCYNGHYS-DSILTFDPDENKW 570
G Y+G + S+ +DP+ + W
Sbjct: 531 G--YDGQSNLSSVEMYDPETDCW 551
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 187 bits (474), Expect = 3e-47
Identities = 148/553 (26%), Positives = 244/553 (44%), Gaps = 48/553 (8%)
Query: 30 LLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFM 89
L DV LV+ + AH+ +L+ S YFR MFT ++ E Q ++ ++ + ++ F
Sbjct: 67 LCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDERAMELLIDFA 126
Query: 90 YYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEG 149
Y I + V +L AA +QL E+ + CC FL ++ NC I D
Sbjct: 127 YTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAFAD-----THS 181
Query: 150 VREKL---DTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLR 206
RE L D F NF +M +F+ L +L+ + +D L+ E +++ AV +W++
Sbjct: 182 CRELLRIADKFTQHNFQEVMESEEFM-LLPANQLIDIISSDELNVRSEEQVFNAVMAWVK 240
Query: 207 HD-RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQ 265
+ + R ++Q++R L++P + V + + + R VD+A NY ++
Sbjct: 241 YSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNYLLLPQER 300
Query: 266 PLLDMKSSRIRSAKP-----QTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPD 320
PL M+ R R KP G ++S + W +
Sbjct: 301 PL--MQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGV 358
Query: 321 CLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSW-LQMADMSVPRSEFAVGVIGK 379
++++++ ++ +GG DG + +S V RYDP+ N W +A S R+ V V+G
Sbjct: 359 GVSVLDDLLYAVGGH----DGSSYLNS-VERYDPKTNQWSSDVAPTSTCRTSVGVAVLGG 413
Query: 380 FIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSST 439
F+YAV G+ ERYD +KW V + G VL L+ GG +S
Sbjct: 414 FLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP 473
Query: 440 SKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVI 499
V ++P + N W + M R Y +Y GG
Sbjct: 474 LNTVERYNPQE---------------NRWHTIAPMGTRRKHLGCAVYQDMIYAVGG---- 514
Query: 500 LRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNG-HYSD 558
++ S E YNP T+QW+ + +M RSG G+ V++ Q+M +GG ++G Y
Sbjct: 515 ---RDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGG--FDGTTYLK 569
Query: 559 SILTFDPDENKWK 571
+I FDPD N W+
Sbjct: 570 TIEVFDPDANTWR 582
Score = 57.8 bits (138), Expect = 3e-08
Identities = 32/93 (34%), Positives = 49/93 (52%), Gaps = 10/93 (10%)
Query: 490 LYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGG 549
L+ GG C S E Y+P+T++W ++ASM R G GV+VLD + +GG
Sbjct: 320 LFAVGGWC-------SGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGG 372
Query: 550 LCYNGH-YSDSILTFDPDENKWKEDEYPRMPCK 581
++G Y +S+ +DP N+W D P C+
Sbjct: 373 --HDGSSYLNSVERYDPKTNQWSSDVAPTSTCR 403
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 186 bits (471), Expect = 7e-47
Identities = 143/546 (26%), Positives = 256/546 (46%), Gaps = 30/546 (5%)
Query: 30 LLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFM 89
L DV LV D + AH+ +L++ SDYF MFT D+RE Q++I ++G+ ++Q+
Sbjct: 173 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYA 232
Query: 90 YYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEG 149
Y G +EL + + +L A +QL +VV+ CC FL+ ++ NC I D G
Sbjct: 233 YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCT--D 290
Query: 150 VREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHD- 208
+ + + +++F+ ++ +F+ L ++ L +D ++ E + A+ +W+RHD
Sbjct: 291 LHKVAHNYTMEHFMEVIRNQEFV-LLPASEIAKLLASDDMNIPNEETILNALLTWVRHDL 349
Query: 209 RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLL 268
+R + ++ IR L+ P + + ++ + +R + + + +A+ Y ++P+L
Sbjct: 350 EQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPML 408
Query: 269 DMKSSRIRSAKPQTT-VFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNN 327
++ R + T GM S + +W + +A++++
Sbjct: 409 QSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDD 468
Query: 328 FVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGR 387
++++GG DG + V Y+P+ +W M MS R V V+ +YAV G
Sbjct: 469 KLYVVGGR----DG-LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGH 523
Query: 388 TRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFD 447
+ ER+D +W FV + VL+ KL+ GG SS K V FD
Sbjct: 524 DGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFD 583
Query: 448 PSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQ 507
P TN W ++M+ R + ++NG LY GG ++ S+
Sbjct: 584 PH---------------TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDA-PASNLTSR 627
Query: 508 GCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGH-YSDSILTFDPD 566
E Y+P+TD WT +ASM I R GV +L ++ +GG Y+G Y +++ +DP
Sbjct: 628 LSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG--YDGQAYLNTVEAYDPQ 685
Query: 567 ENKWKE 572
N+W +
Sbjct: 686 TNEWTQ 691
Score = 48.9 bits (115), Expect = 1e-05
Identities = 27/94 (28%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 326 NNFVFLLGGEELGPDG-EFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAV 384
N ++ +GG + S V RYDP+ + W +A MS+ R V ++G +YAV
Sbjct: 608 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 667
Query: 385 AGRTRDETFYSTERYDITNDKWEFVDPYPVNKYG 418
G + E YD ++W V P + + G
Sbjct: 668 GGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 701
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 186 bits (471), Expect = 7e-47
Identities = 143/546 (26%), Positives = 256/546 (46%), Gaps = 30/546 (5%)
Query: 30 LLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFM 89
L DV LV D + AH+ +L++ SDYF MFT D+RE Q++I ++G+ ++Q+
Sbjct: 219 LCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYA 278
Query: 90 YYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEG 149
Y G +EL + + +L A +QL +VV+ CC FL+ ++ NC I D G
Sbjct: 279 YTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCT--D 336
Query: 150 VREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHD- 208
+ + + +++F+ ++ +F+ L ++ L +D ++ E + A+ +W+RHD
Sbjct: 337 LHKVAHNYTMEHFMEVIRNQEFV-LLPASEIAKLLASDDMNIPNEETILNALLTWVRHDL 395
Query: 209 RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLL 268
+R + ++ IR L+ P + + ++ + +R + + + +A+ Y ++P+L
Sbjct: 396 EQRRKDLSKLLAYIRLPLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPML 454
Query: 269 DMKSSRIRSAKPQTT-VFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNN 327
++ R + T GM S + +W + +A++++
Sbjct: 455 QSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDD 514
Query: 328 FVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGR 387
++++GG DG + V Y+P+ +W M MS R V V+ +YAV G
Sbjct: 515 KLYVVGGR----DG-LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGH 569
Query: 388 TRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFD 447
+ ER+D +W FV + VL+ KL+ GG SS K V FD
Sbjct: 570 DGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFD 629
Query: 448 PSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQ 507
P TN W ++M+ R + ++NG LY GG ++ S+
Sbjct: 630 PH---------------TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDA-PASNLTSR 673
Query: 508 GCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGH-YSDSILTFDPD 566
E Y+P+TD WT +ASM I R GV +L ++ +GG Y+G Y +++ +DP
Sbjct: 674 LSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG--YDGQAYLNTVEAYDPQ 731
Query: 567 ENKWKE 572
N+W +
Sbjct: 732 TNEWTQ 737
Score = 48.9 bits (115), Expect = 1e-05
Identities = 27/94 (28%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 326 NNFVFLLGGEELGPDG-EFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAV 384
N ++ +GG + S V RYDP+ + W +A MS+ R V ++G +YAV
Sbjct: 654 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 713
Query: 385 AGRTRDETFYSTERYDITNDKWEFVDPYPVNKYG 418
G + E YD ++W V P + + G
Sbjct: 714 GGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 747
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 183 bits (465), Expect = 3e-46
Identities = 156/572 (27%), Positives = 249/572 (43%), Gaps = 78/572 (13%)
Query: 24 LYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFS 83
L + LL DVT+V ED + AH+ +LA S YF MFT +M E ++ +K +
Sbjct: 53 LRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLR 112
Query: 84 HVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDF 143
++ ++Y I+++ V +L AA +QL +V K CC FL +++ NC I D
Sbjct: 113 MLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMH 172
Query: 144 GVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQS 203
+ K +T+ +F ++ +FL+ L E++ S + +D L+ E +++EAV +
Sbjct: 173 ACT--DLLNKANTYAEQHFADVVLSEEFLN-LGIEQVCSLISSDKLTISSEEKVFEAVIA 229
Query: 204 WLRHDRR-RWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNV 262
W+ HD+ R +++++R L+ + ++V+ + S + + +A+ Y
Sbjct: 230 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 289
Query: 263 HQQPLLDMKSSRIRSAKPQT-----TVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPL 317
+Q +L MKS R R P V G ++ + + K+ R E P
Sbjct: 290 TEQRIL-MKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC 348
Query: 318 RPDCLAIVNNFVFLLGG------------------------------EELGPD------- 340
R + + VF +GG LG
Sbjct: 349 RAG-MVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLY 407
Query: 341 --GEFHAS---SKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAG--RTRDETF 393
G F S S V Y+ + N W +A M+ RS VGV+G +YAV G +
Sbjct: 408 AVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCL 467
Query: 394 YSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGT 453
+ E Y+ T ++W ++ + G VLNN L+ GG K V V+DP+
Sbjct: 468 STVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPT---- 523
Query: 454 IEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTE 513
TN W + MN R + + NG LYV GG S S E
Sbjct: 524 -----------TNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-------DDGSCNLASVE 565
Query: 514 VYNPETDQWTILAS-MPIGRSGHGVTVLDKQI 544
YNP TD+WT+++S M GRS GVTV+DK +
Sbjct: 566 YYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 597
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 183 bits (465), Expect = 3e-46
Identities = 156/572 (27%), Positives = 249/572 (43%), Gaps = 78/572 (13%)
Query: 24 LYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFS 83
L + LL DVT+V ED + AH+ +LA S YF MFT +M E ++ +K +
Sbjct: 49 LRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLR 108
Query: 84 HVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDF 143
++ ++Y I+++ V +L AA +QL +V K CC FL +++ NC I D
Sbjct: 109 MLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMH 168
Query: 144 GVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQS 203
+ K +T+ +F ++ +FL+ L E++ S + +D L+ E +++EAV +
Sbjct: 169 ACT--DLLNKANTYAEQHFADVVLSEEFLN-LGIEQVCSLISSDKLTISSEEKVFEAVIA 225
Query: 204 WLRHDRR-RWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNV 262
W+ HD+ R +++++R L+ + ++V+ + S + + +A+ Y
Sbjct: 226 WVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLP 285
Query: 263 HQQPLLDMKSSRIRSAKPQT-----TVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPL 317
+Q +L MKS R R P V G ++ + + K+ R E P
Sbjct: 286 TEQRIL-MKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRC 344
Query: 318 RPDCLAIVNNFVFLLGG------------------------------EELGPD------- 340
R + + VF +GG LG
Sbjct: 345 RAG-MVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLY 403
Query: 341 --GEFHAS---SKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAG--RTRDETF 393
G F S S V Y+ + N W +A M+ RS VGV+G +YAV G +
Sbjct: 404 AVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCL 463
Query: 394 YSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGT 453
+ E Y+ T ++W ++ + G VLNN L+ GG K V V+DP+
Sbjct: 464 STVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPT---- 519
Query: 454 IEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTE 513
TN W + MN R + + NG LYV GG S S E
Sbjct: 520 -----------TNAWRQVADMNMCRRNAGVCAVNGLLYVVGG-------DDGSCNLASVE 561
Query: 514 VYNPETDQWTILAS-MPIGRSGHGVTVLDKQI 544
YNP TD+WT+++S M GRS GVTV+DK +
Sbjct: 562 YYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL 593
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 182 bits (462), Expect = 8e-46
Identities = 138/557 (24%), Positives = 248/557 (44%), Gaps = 38/557 (6%)
Query: 21 FRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTAT 80
F L EG L DV + + +F AHK +L + S YFR +FT+ ++ ++ G++
Sbjct: 29 FNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPD 88
Query: 81 GFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLL 140
++++ Y T+ ++ + V ++L AA ++ +V+ CC FL +++CL+NC I +
Sbjct: 89 MMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFT 148
Query: 141 DDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEA 200
D + +R+K F+L NF ++ LS +L ++ D L+ E ++EA
Sbjct: 149 DYY--YCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEA 206
Query: 201 VQSWLRHD-RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALN-- 257
+ W+ HD + R +H ++ +R LM VK +++ + S + + + AL
Sbjct: 207 ILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAM 266
Query: 258 YFQNVHQQPLLDMKSSRIRSAKPQTTVFR--GMIGHSMVNSKILLLKKPRVWWELE-GPQ 314
Y N++ D + R P +F G G S N+ + W + +
Sbjct: 267 YDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEE 326
Query: 315 VPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAV 374
P A + +V+++GG + + V R+DP + +W Q+A M R +V
Sbjct: 327 SPRAYHGAAYLKGYVYIIGGFD-----SVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSV 381
Query: 375 GVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGI 434
V+G FIYA+ G + ERY+ ++W + P + T L K++I GG
Sbjct: 382 TVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGF 441
Query: 435 TSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFG 494
+ C+F T +N W + M R +I+Y +Y G
Sbjct: 442 NGNE-----CLFTAEVYNT----------ESNQWTVIAPMRSRRSGIGVIAYGEHVYAVG 486
Query: 495 GVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNG 554
G R S E Y+P + W + +M RS G+ V+D + V+GG +NG
Sbjct: 487 GFDGANRLR-------SAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG--FNG 537
Query: 555 HYSD-SILTFDPDENKW 570
+ ++ +D ++W
Sbjct: 538 FTTTFNVECYDEKTDEW 554
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 178 bits (452), Expect = 1e-44
Identities = 140/572 (24%), Positives = 259/572 (45%), Gaps = 61/572 (10%)
Query: 20 GFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTA 79
G L E L DV L ++ +F H+ +LA S+YFR MF D++E+ + +I +KG+ A
Sbjct: 61 GLETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDA 120
Query: 80 TGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRL 139
+L + Y ++ V +L+AA Q + +V C SFL + ENC I+RL
Sbjct: 121 ETMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRL 180
Query: 140 LDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYE 199
D +++ +++++ ++++ NFV +++ +FL L + L L +D L E +++E
Sbjct: 181 ADTH--SLDSLKKQVQSYIIQNFVQILNSEEFLD-LPVDTLHHILKSDDLYVTEEAQVFE 237
Query: 200 AVQSWLRH-DRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNY 258
V SW+RH R +++N+R L+ P E V+ R ++ + +A Y
Sbjct: 238 TVMSWVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMY 297
Query: 259 FQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIG--------------HSMVNSKILLLKKP 304
+ ++ + + ++ R + Q+ VF + G + S++ + K P
Sbjct: 298 HLSGNE---IISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLP 354
Query: 305 RVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMAD 364
ELE + N V++ GG+E D V++Y+ N W+Q+
Sbjct: 355 LTEHELESENKKWVEFACVTLKNEVYISGGKETQHD--------VWKYNSSINKWIQIEY 406
Query: 365 MSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVL 424
+++ R + V+G +Y + G + + E YD ++ W P V+ T
Sbjct: 407 LNIGRWRHKMVVLGGKVYVIGGFDGLQRINNVETYDPFHNCWSEAAPLLVHVSSFAATSH 466
Query: 425 NNKLFITGGITSS--STSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNY-ARCFH 481
KL++ GG + +T K C +DPS TN W K+ M A+C +
Sbjct: 467 KKKLYVIGGGPNGKLATDKTQC-YDPS---------------TNKWSLKAAMPVEAKCIN 510
Query: 482 KMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLD 541
+S+ ++YV GG +RA + Y+P D W ++ + R+ G+ +
Sbjct: 511 -AVSFRDRIYVVGGA---MRALY---------AYSPLEDSWCLVTQLSHERASCGIAPCN 557
Query: 542 KQIMVLGGLCYNGHYSDSILTFDPDENKWKED 573
++ + GG ++L +DP+ K E+
Sbjct: 558 NRLYITGGRDEKNEVIATVLCWDPEAQKLTEE 589
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 176 bits (447), Expect = 4e-44
Identities = 144/554 (25%), Positives = 247/554 (44%), Gaps = 47/554 (8%)
Query: 30 LLDVTLVIEDH-----QFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSH 84
L DVTL ++ QF AHK +LA+ S F+ MFT +RE+ + + ++G+
Sbjct: 76 LCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMER 135
Query: 85 VLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFG 144
+++F Y +I + V ++ A+ Q+ VV+ C FL+ ++ N I + G
Sbjct: 136 LIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIG 195
Query: 145 VNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSW 204
+E + ++ ++ +F + + +F + LS +L++ + D L+ E E++ A +W
Sbjct: 196 C-VE-LHQRAREYIYMHFGEVAKQEEFFN-LSHCQLVTLISRDDLNVRCESEVFHACINW 252
Query: 205 LRHD-RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVH 263
+++D +R + +++ +R +TP + +++ E + + + +Y +
Sbjct: 253 VKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK-------DYLVKIF 305
Query: 264 QQPLLDMKSSRIRSAKPQT-TVFRGMIGHSMVNSKILLLKKPR--VWWELEGPQVPLRPD 320
++ L + + P+ + G+ + L P W L QVP
Sbjct: 306 EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGL 365
Query: 321 CLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKF 380
+V ++ +GG PDG SS + Y+P N W A MSVPR+ VGVI
Sbjct: 366 AGCVVGGLLYAVGGRNNSPDGNTD-SSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGH 424
Query: 381 IYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTS 440
IYAV G S ERY+ D+W V P + G VLN L+ GG ++
Sbjct: 425 IYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRL 484
Query: 441 KQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVIL 500
+ P + N W + MN R + + +Y GG
Sbjct: 485 NSAECYYPER---------------NEWRMITAMNTIRSGAGVCVLHNCIYAAGG----- 524
Query: 501 RASFESQG-CPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGH-YSD 558
++ Q S E Y+ ET+ WT +A M RS G+TV +I VLGG Y+GH + D
Sbjct: 525 ---YDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG--YDGHTFLD 579
Query: 559 SILTFDPDENKWKE 572
S+ +DPD + W E
Sbjct: 580 SVECYDPDTDTWSE 593
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 176 bits (447), Expect = 4e-44
Identities = 144/554 (25%), Positives = 247/554 (44%), Gaps = 47/554 (8%)
Query: 30 LLDVTLVIEDH-----QFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSH 84
L DVTL ++ QF AHK +LA+ S F+ MFT +RE+ + + ++G+
Sbjct: 76 LCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMER 135
Query: 85 VLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFG 144
+++F Y +I + V ++ A+ Q+ VV+ C FL+ ++ N I + G
Sbjct: 136 LIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIG 195
Query: 145 VNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSW 204
+E + ++ ++ +F + + +F + LS +L++ + D L+ E E++ A +W
Sbjct: 196 C-VE-LHQRAREYIYMHFGEVAKQEEFFN-LSHCQLVTLISRDDLNVRCESEVFHACINW 252
Query: 205 LRHD-RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVH 263
+++D +R + +++ +R +TP + +++ E + + + +Y +
Sbjct: 253 VKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK-------DYLVKIF 305
Query: 264 QQPLLDMKSSRIRSAKPQT-TVFRGMIGHSMVNSKILLLKKPR--VWWELEGPQVPLRPD 320
++ L + + P+ + G+ + L P W L QVP
Sbjct: 306 EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGL 365
Query: 321 CLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKF 380
+V ++ +GG PDG SS + Y+P N W A MSVPR+ VGVI
Sbjct: 366 AGCVVGGLLYAVGGRNNSPDGNTD-SSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGH 424
Query: 381 IYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTS 440
IYAV G S ERY+ D+W V P + G VLN L+ GG ++
Sbjct: 425 IYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRL 484
Query: 441 KQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVIL 500
+ P + N W + MN R + + +Y GG
Sbjct: 485 NSAECYYPER---------------NEWRMITAMNTIRSGAGVCVLHNCIYAAGG----- 524
Query: 501 RASFESQG-CPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGH-YSD 558
++ Q S E Y+ ET+ WT +A M RS G+TV +I VLGG Y+GH + D
Sbjct: 525 ---YDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG--YDGHTFLD 579
Query: 559 SILTFDPDENKWKE 572
S+ +DPD + W E
Sbjct: 580 SVECYDPDTDTWSE 593
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 172 bits (437), Expect = 6e-43
Identities = 150/572 (26%), Positives = 249/572 (43%), Gaps = 45/572 (7%)
Query: 10 SSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQ 69
++ H S+ +L + L DVTL +E F AH+ +LA SDYF MFT+++ E+ +
Sbjct: 12 TNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGK 71
Query: 70 DKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKIC 129
+ ++GLTA+ +L F+Y T+ +++ V E+L AA +QL V + CC FL +++
Sbjct: 72 PYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLD 131
Query: 130 LENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHL 189
NC I + N + + + F +F ++ +F+ LS ++ + D +
Sbjct: 132 PSNCLGIRDFAETH--NCVDLMQAAEVFSQKHFPEVVQHEEFI-LLSQGEVEKLIKCDEI 188
Query: 190 SRFPEIELYEAVQSWLRHDRR-RWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQL 248
E ++EAV +W++H ++ R ++Q +R L+TP + + + F R S Q
Sbjct: 189 QVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQC 248
Query: 249 RYEVDQALNYFQNVHQQPLL--DMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLK---- 302
R VD+A + H +P L M+ R R+ V + G S I +++
Sbjct: 249 RDLVDEAKKF----HLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDP 304
Query: 303 KPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASS-KVFRYDPRQNS-WL 360
K + W L R +++ ++++GG DG SS + Y ++ W
Sbjct: 305 KTQEWSFLPSITRKRRYVASVSLHDRIYVIGGY----DGRSRLSSVECLDYTADEDGVWY 360
Query: 361 QMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHE 420
+A M+V R +G IY G S ERYD D+W + + G
Sbjct: 361 SVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAG 420
Query: 421 GTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCF 480
V + ++ GG + V +DP T W N + M R
Sbjct: 421 LVVASGVIYCLGGYDGLNILNSVEKYDPH---------------TGHWTNVTPMATKRSG 465
Query: 481 HKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVL 540
+ N +YV GG S S E YN TD WT + SM R G TVL
Sbjct: 466 AGVALLNDHIYVVGGFDGTAHLS-------SVEAYNIRTDSWTTVTSMTTPRCYVGATVL 518
Query: 541 DKQIMVLGGLCYNGH-YSDSILTFDPDENKWK 571
++ + G Y+G+ SI +DP + W+
Sbjct: 519 RGRLYAIAG--YDGNSLLSSIECYDPIIDSWE 548
Score = 50.1 bits (118), Expect = 6e-06
Identities = 30/88 (34%), Positives = 46/88 (52%), Gaps = 5/88 (5%)
Query: 322 LAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFI 381
+A++N+ ++++GG DG H SS V Y+ R +SW + M+ PR V+ +
Sbjct: 468 VALLNDHIYVVGGF----DGTAHLSS-VEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRL 522
Query: 382 YAVAGRTRDETFYSTERYDITNDKWEFV 409
YA+AG + S E YD D WE V
Sbjct: 523 YAIAGYDGNSLLSSIECYDPIIDSWEVV 550
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 172 bits (436), Expect = 8e-43
Identities = 135/530 (25%), Positives = 247/530 (46%), Gaps = 30/530 (5%)
Query: 46 KALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEIL 105
+ +L++ SDYF MFT D+RE Q++I ++G+ ++Q+ Y G +EL + + +L
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 106 QAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPL 165
A +QL +VV+ CC FL+ ++ NC I D G + + + +++F+ +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCT--DLHKVAHNYTMEHFMEV 291
Query: 166 MSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHD-RRRWRHTDTIIQNIRF 224
+ +F+ L ++ L +D ++ E + A+ +W+RHD +R + ++ IR
Sbjct: 292 IRNQEFV-LLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRL 350
Query: 225 CLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLLDMKSSRIRSAKPQTT- 283
L+ P + + ++ + +R + + + +A+ Y ++P+L ++ R + T
Sbjct: 351 PLLAPQFLAD-MENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLF 409
Query: 284 VFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEF 343
GM S + +W + +A++++ ++++GG DG
Sbjct: 410 AVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR----DG-L 464
Query: 344 HASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITN 403
+ V Y+P+ +W M MS R V V+ +YAV G + ER+D
Sbjct: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQA 524
Query: 404 DKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQV 463
+W FV + VL+ KL+ GG SS K V FDP
Sbjct: 525 RQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPH-------------- 570
Query: 464 VTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWT 523
TN W ++M+ R + ++NG LY GG ++ S+ E Y+P+TD WT
Sbjct: 571 -TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDA-PASNLTSRLSDCVERYDPKTDMWT 628
Query: 524 ILASMPIGRSGHGVTVLDKQIMVLGGLCYNGH-YSDSILTFDPDENKWKE 572
+ASM I R GV +L ++ +GG Y+G Y +++ +DP N+W +
Sbjct: 629 AVASMSISRDAVGVCLLGDKLYAVGG--YDGQAYLNTVEAYDPQTNEWTQ 676
Score = 48.9 bits (115), Expect = 1e-05
Identities = 27/94 (28%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 326 NNFVFLLGGEELGPDG-EFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAV 384
N ++ +GG + S V RYDP+ + W +A MS+ R V ++G +YAV
Sbjct: 593 NGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAV 652
Query: 385 AGRTRDETFYSTERYDITNDKWEFVDPYPVNKYG 418
G + E YD ++W V P + + G
Sbjct: 653 GGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAG 686
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 172 bits (435), Expect = 1e-42
Identities = 139/546 (25%), Positives = 257/546 (47%), Gaps = 30/546 (5%)
Query: 30 LLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFM 89
L DV L++ + + AH+ +L++ SDYF MFT+D+ E Q++I ++G+ ++QF
Sbjct: 211 LCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFA 270
Query: 90 YYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGVNIEG 149
Y G +EL +T+ +L AA +QL +VV+ CC FL+ + NC I D G IE
Sbjct: 271 YTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGC-IE- 328
Query: 150 VREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSWLRHD- 208
+ + ++ ++N + ++ +FL L E+L L +D ++ E ++ A+ W+++D
Sbjct: 329 LMKVAHSYTMENIMEVIRNQEFL-LLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDM 387
Query: 209 RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVHQQPLL 268
+ R ++ IR L+ P + ++ ++ + + + +A+ Y ++ L+
Sbjct: 388 QSRCNDLSMLLAFIRLPLL-PPQILADLENHALFKNDLECQKLILEAMKYHLLPERRTLM 446
Query: 269 DMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDC-LAIVNN 327
++ R + T G + ++ + I W G R +A++++
Sbjct: 447 QSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDD 506
Query: 328 FVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGR 387
+F++GG DG + V Y+P+ +W + MS R V V+ IYAV G
Sbjct: 507 KLFVIGGR----DG-LKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGH 561
Query: 388 TRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQVCVFD 447
+ ER+D + +W FV + + LN KL+ GG SS + +D
Sbjct: 562 DGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYD 621
Query: 448 PSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQ 507
P TN W + M R + + +G LY GG ++ S+
Sbjct: 622 PH---------------TNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDA-PASNHCSR 665
Query: 508 GCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGH-YSDSILTFDPD 566
E Y+P+TD WT++A + + R GV +L ++ +GG Y+G Y +++ ++DP
Sbjct: 666 LLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG--YDGQTYLNTMESYDPQ 723
Query: 567 ENKWKE 572
N+W +
Sbjct: 724 TNEWTQ 729
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 171 bits (433), Expect = 2e-42
Identities = 139/556 (25%), Positives = 255/556 (45%), Gaps = 40/556 (7%)
Query: 26 EEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHV 85
+E L DV L+ + AH+ +L+ SDYF MFT D+ E Q+++ ++G+ + +
Sbjct: 177 KEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSL 236
Query: 86 LQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGV 145
+Q+ Y G ++L +T+ +L AA +QL +V+ C +FL+ ++ NC I FG
Sbjct: 237 VQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIR----SFG- 291
Query: 146 NIEGVREKLDT---FLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQ 202
+ +G E L+ + +++F+ ++ +FL L ++ L +D ++ E ++ A+
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFL-LLPANEISKLLCSDDINVPDEETIFHALM 350
Query: 203 SWLRHD-RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQN 261
W+ HD + R ++ IR L+ P + ++TS + + + + +A+ Y
Sbjct: 351 QWVGHDVQNRQGELGMLLSYIRLPLL-PPQLLADLETSSMFTGDLECQKLLMEAMKYHLL 409
Query: 262 VHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLK---KPRVWWELEGPQVPLR 318
++ + M+S R + K + G + + K + W +
Sbjct: 410 PERRSM--MQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRL 467
Query: 319 PDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIG 378
+A+++N ++++GG DG + V ++P W M MS R V +
Sbjct: 468 QFGVAVIDNKLYVVGGR----DG-LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
Query: 379 KFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSS 438
+YAV G + ER+D +W +V + LNNKL+ GG SS
Sbjct: 523 GPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS 582
Query: 439 TSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCV 498
K + FDP TN W + M+ R + +YNG LYV GG
Sbjct: 583 CLKSMEYFDPH---------------TNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDA 627
Query: 499 ILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGH-YS 557
++ S+ E Y+P+ D W+ +A + + R V L ++ V+GG Y+GH Y
Sbjct: 628 -PASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG--YDGHTYL 684
Query: 558 DSILTFDPDENKWKED 573
+++ ++D N+WKE+
Sbjct: 685 NTVESYDAQRNEWKEE 700
Score = 55.5 bits (132), Expect = 1e-07
Identities = 34/113 (30%), Positives = 52/113 (46%), Gaps = 2/113 (1%)
Query: 308 WELEGPQVPLRPDC-LAIVNNFVFLLGGEELGPDGEF-HASSKVFRYDPRQNSWLQMADM 365
W L P R +A N F++++GG + S V RYDP+ +SW +A +
Sbjct: 597 WSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPL 656
Query: 366 SVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYG 418
SVPR AV +G +Y V G + E YD ++W+ P + + G
Sbjct: 657 SVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG 709
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 171 bits (432), Expect = 2e-42
Identities = 141/558 (25%), Positives = 248/558 (44%), Gaps = 47/558 (8%)
Query: 25 YEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSH 84
YE G L DVTL + HK +LA YFR MF ++M E Q I ++
Sbjct: 61 YENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIED 120
Query: 85 VLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFG 144
+++F+Y + L+++ V +L AA +Q+ V + CC ++ NC + +
Sbjct: 121 LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESH- 179
Query: 145 VNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQSW 204
N + + D + D+F ++ DF+S +S + L L + L+ E ++Y A W
Sbjct: 180 -NRIDLMDMADQYACDHFTEVVECEDFVS-VSPQHLHKLLSSSDLNIENEKQVYNAAIKW 237
Query: 205 -LRHDRRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNVH 263
L + + + D + +R L+ + V + + + + R +D+A NY ++
Sbjct: 238 LLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLS 297
Query: 264 QQPLLDMKSSRIRSAKPQTTV-------FRGMIGHSMVNSKILLLKKPRVWWELEGPQVP 316
+ + D + S IR+ + T RG G + + + K W+ GP++
Sbjct: 298 SRAVPDFEYS-IRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINK-NSWF--FGPEMN 353
Query: 317 LRPDCLAI--VNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAV 374
R + + V V+ +GG DG H S + +DP N W+ A M+ R A+
Sbjct: 354 SRRRHVGVISVEGKVYAVGGH----DGNEHLGS-MEMFDPLTNKWMMKASMNTKRRGIAL 408
Query: 375 GVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGI 434
+G IYA+ G + F ERYDI +D+W V P + G L N ++ GG
Sbjct: 409 ASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGN 468
Query: 435 TSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFG 494
++ V +DP + IE + +M R + + +G LYV G
Sbjct: 469 DGMASLSSVERYDPHLDKWIEVK---------------EMGQRRAGNGVSKLHGCLYVVG 513
Query: 495 GVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNG 554
G ++ S E Y+P +++W +A++ R G G+ + +I +GG +NG
Sbjct: 514 GF-------DDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGG--HNG 564
Query: 555 H-YSDSILTFDPDENKWK 571
+ Y +++ FDP N+W+
Sbjct: 565 NAYLNTVEAFDPVLNRWE 582
Score = 45.4 bits (106), Expect = 1e-04
Identities = 21/63 (33%), Positives = 32/63 (50%)
Query: 347 SKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKW 406
S V RYDPR N W +A ++ PR + + I+AV G + + E +D ++W
Sbjct: 522 SSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRW 581
Query: 407 EFV 409
E V
Sbjct: 582 ELV 584
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 170 bits (431), Expect = 3e-42
Identities = 139/555 (25%), Positives = 254/555 (45%), Gaps = 40/555 (7%)
Query: 26 EEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHV 85
+E L DV L+ + AH+ +L+ SDYF MFT D+ E Q+++ ++G+ + +
Sbjct: 177 KEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALNSL 236
Query: 86 LQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDFGV 145
+Q+ Y G ++L +T+ +L AA +QL +V+ C +FL+ ++ NC I FG
Sbjct: 237 VQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIR----SFG- 291
Query: 146 NIEGVREKLDT---FLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQ 202
+ +G E L+ + +++F+ ++ +FL L ++ L +D ++ E ++ A+
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFL-LLPANEISKLLCSDDINVPDEETIFHALM 350
Query: 203 SWLRHD-RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQN 261
W+ HD + R ++ IR L+ P + ++TS + + + + +A+ Y
Sbjct: 351 QWVGHDVQNRQGELGMLLSYIRLPLL-PPQLLADLETSSMFTGDLECQKLLMEAMKYHLL 409
Query: 262 VHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLK---KPRVWWELEGPQVPLR 318
++ + M+S R + K + G + + K + W +
Sbjct: 410 PERRSM--MQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRL 467
Query: 319 PDCLAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIG 378
+A+++N ++++GG DG + V ++P W M MS R V +
Sbjct: 468 QFGVAVIDNKLYVVGGR----DG-LKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLE 522
Query: 379 KFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSS 438
+YAV G + ER+D +W +V + LNNKL+ GG SS
Sbjct: 523 GPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS 582
Query: 439 TSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCV 498
K + FDP TN W + M+ R + +YNG LYV GG
Sbjct: 583 CLKSMEYFDPH---------------TNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDA 627
Query: 499 ILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGH-YS 557
++ S+ E Y+P+ D W+ +A + + R V L ++ V+GG Y+GH Y
Sbjct: 628 -PASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG--YDGHTYL 684
Query: 558 DSILTFDPDENKWKE 572
+++ ++D N+WKE
Sbjct: 685 NTVESYDAQRNEWKE 699
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 170 bits (431), Expect = 3e-42
Identities = 136/566 (24%), Positives = 253/566 (44%), Gaps = 35/566 (6%)
Query: 12 IHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDK 71
+H + G L + L D+ L + D + AHK +LA+ S YF+ MFT ++ E++ +
Sbjct: 16 LHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSE 75
Query: 72 IHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLE 131
+ + + T ++++ Y GT+ +S +TV +L AA +Q+ V+K CC+FL +++
Sbjct: 76 VEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPG 135
Query: 132 NCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSR 191
NC I R + +G + ++ NF + +F L+ L + ND L+
Sbjct: 136 NCIGISRFAETYG--CRDLYLAATKYICQNFEAVCQTEEFFE-LTHADLDEIVSNDCLNV 192
Query: 192 FPEIELYEAVQSWLRHD-RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRY 250
E ++ A++SW+++D + R ++ ++ ++R L++ + + + R R ++
Sbjct: 193 ATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKH 252
Query: 251 EVDQALNY-FQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIG-HSMVNSKILLLKKPRVWW 308
+++AL Y F H+ + +R R A G G + ++S + + W
Sbjct: 253 LLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWI 312
Query: 309 ELEGPQVPLRPDCLAIVNNFVFLLGG----EELGPDGEFHASSKVFRYDPRQNSWLQMAD 364
L +P + +++ V+++GG G H +S V ++P N+W +
Sbjct: 313 GLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENS-VECWNPDTNTWTSLER 371
Query: 365 MSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVL 424
M+ RS V V+ +YA+ G S E+Y KW+ V P + VL
Sbjct: 372 MNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVL 431
Query: 425 NNKLFITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMI 484
+ ++ GG + V +DPSK+ WE + M R +
Sbjct: 432 DGMIYAIGGY-GPAHMNSVERYDPSKDS---------------WEMVASMADKRIHFGVG 475
Query: 485 SYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQI 544
G ++V GG + S S E Y+P +QWT+ M R+G G V+D +
Sbjct: 476 VMLGFIFVVGGHNGVSHLS-------SIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYL 528
Query: 545 MVLGGLCYNGHYSDSILTFDPDENKW 570
V+GG Y +++ +DP + W
Sbjct: 529 YVVGGHS-GSSYLNTVQKYDPISDTW 553
Score = 30.4 bits (67), Expect = 4.9
Identities = 15/52 (28%), Positives = 30/52 (57%), Gaps = 5/52 (9%)
Query: 323 AIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAV 374
A+++N+++++GG G + ++ V +YDP ++WL A M R F +
Sbjct: 522 AVIDNYLYVVGGHS----GSSYLNT-VQKYDPISDTWLDSAGMIYCRCNFGL 568
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 163 bits (413), Expect = 4e-40
Identities = 146/552 (26%), Positives = 239/552 (43%), Gaps = 78/552 (14%)
Query: 24 LYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFS 83
L + LL DV +V ED + +AH+ +LA S YF MFT DM E KI +K + S
Sbjct: 43 LRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLS 102
Query: 84 HVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLENCAEIMRLLDDF 143
++ ++Y IE++ V +L AA +QL++V + CC FL +++ NC I D
Sbjct: 103 KLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFADVH 162
Query: 144 GVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRFPEIELYEAVQS 203
+ ++ + + +F +M +FLS LS +++ S + +D L+ E +++EAV S
Sbjct: 163 --TCTDLLQQANAYAEQHFPEVMLGEEFLS-LSLDQVCSLISSDKLTVSSEEKVFEAVIS 219
Query: 204 WLRHDRR-RWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYEVDQALNYFQNV 262
W+ +++ R H +++++R L+ + + V+ + + + + +A+ Y
Sbjct: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKY---- 275
Query: 263 HQQPLLDMKSSRIRSAKPQTTVFRGMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCL 322
H PL + LL+K PR P+ P+ +
Sbjct: 276 HLLPL----------------------------DQRLLIKNPRT-----KPRTPVSLPKV 302
Query: 323 AIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVPRSEFAVGVIGKFIY 382
IV +GG+ A V YD ++ W Q+A++ R V + +Y
Sbjct: 303 MIV------VGGQAP------KAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVY 350
Query: 383 AVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTSKQ 442
AV G + + YD D+W + + VLN+ L+ GG S+
Sbjct: 351 AVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLAS 410
Query: 443 VCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRA 502
V + TN W + MN R + GKLY GG
Sbjct: 411 VEAYSYK---------------TNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGY------ 449
Query: 503 SFESQGCPST-EVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVLGGLCYNGHY-SDSI 560
S+ C ST E YNP T++W +A M RSG GV VL Q+ GG ++G S+
Sbjct: 450 DGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG--HDGPLVRKSV 507
Query: 561 LTFDPDENKWKE 572
+DP N WK+
Sbjct: 508 EVYDPGTNTWKQ 519
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 160 bits (404), Expect = 4e-39
Identities = 141/593 (23%), Positives = 258/593 (43%), Gaps = 66/593 (11%)
Query: 8 FCSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRER 67
F S H + A + DV L + F+AH+ +LA S YF +FT M+E
Sbjct: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73
Query: 68 DQDKIHLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAK 127
+D + + G+ A F +L F+Y G + + +N V E++ AA +QL EVV CC FL +
Sbjct: 74 SKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQ 133
Query: 128 ICLENCAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDND 187
I NC I + + + + E + ++ +F+ + S +FL+ L+ ++L+ L ++
Sbjct: 134 IDPLNCIGIFQFSEQIACH--DLLEFSENYIHVHFLEVHSGEEFLA-LTKDQLIKILRSE 190
Query: 188 HLSRFPEIELYEAVQSWLRHDR-RRWRHTDTIIQNIRFCLMTPTSVFEKVK-TSEFYRYS 245
LS E +++ A W+ D +R +H ++ IRF L+ P + + ++ S+F
Sbjct: 191 ELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDF---- 246
Query: 246 RQLRYEVDQALNYFQNVHQQPLLD-----MKSSRIRSAKPQTTVFRGMIGHSMV------ 294
LR + L + V + P + +++S++R K + G++ +
Sbjct: 247 -NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWS 305
Query: 295 NSKILLLKK-----PRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHASSKV 349
+S+ L + + W + + ++ V+ +GGE+ S +
Sbjct: 306 DSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEK---------DSMI 356
Query: 350 FR----YDPRQNSWLQMADMSVPRSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDK 405
F YDP W +A M+ PR V V IYA+ G E + ER+D +K
Sbjct: 357 FDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENK 416
Query: 406 WEFVDPYPVNKYGHEGTVLNNKLFITGGITSSSTS-KQVCVFDPSKEGTIEQRTRRTQVV 464
WE V V++Y + +++ GGI++ + V+DP +
Sbjct: 417 WEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDP---------------L 461
Query: 465 TNCWENKSKMNYARCFHKMISYNGKLYVFGGVCVILRASFESQGCPSTEVYNPETDQWTI 524
+ W M R + + + N +Y GG + + E Y+ E ++W
Sbjct: 462 SKRWSPLPPMGTRRAYLGVAALNDCIYSVGG------WNETQDALHTVEKYSFEEEKWVE 515
Query: 525 LASMPIGRSGHGVTVLDKQIMVLGGLCYNGHY-----SDSILTFDPDENKWKE 572
+ASM + R+G V ++ + V GG + + DS+ ++P + W E
Sbjct: 516 VASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTE 568
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 158 bits (399), Expect = 2e-38
Identities = 143/564 (25%), Positives = 233/564 (41%), Gaps = 41/564 (7%)
Query: 13 HDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKI 72
HD V+ + + GLL D+ L + + +AHK +LA+ S YF MFT +M E Q +
Sbjct: 76 HDAFVAMS--RMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHV 133
Query: 73 HLKGLTATGFSHVLQFMYYGTIELSMNTVHEILQAAMYVQLIEVVKFCCSFLLAKICLEN 132
L + ++QF Y I + V +L AA +QL V CC FLL+++ N
Sbjct: 134 TLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSN 193
Query: 133 CAEIMRLLDDFGVNIEGVREKLDTFLLDNFVPLMSRPDFLSYLSFEKLMSYLDNDHLSRF 192
C I D + + + ++L +FV + +F+ L ++++ + +D L+
Sbjct: 194 CLGIRGFAD--AHSCSDLLKAAHRYVLQHFVDVAKTEEFM-LLPLKQVLELVSSDSLNVP 250
Query: 193 PEIELYEAVQSWLRHD-RRRWRHTDTIIQNIRFCLMTPTSVFEKVKTSEFYRYSRQLRYE 251
E E+Y AV SW++HD R +H +++ +R L++ + V R+ +
Sbjct: 251 SEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDL 310
Query: 252 VDQALNYFQNVHQQPLLDMKSSRIRSAKPQTTVFRGMIGHSM--VNSKILLLKKPRVWWE 309
+ +AL + Q+ +L +R R + V + G S+ ++ W
Sbjct: 311 LIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWH 370
Query: 310 LEGPQVPLRPDC-LAIVNNFVFLLGGEELGPDGEFHASSKVFRYDPRQNSWLQMADMSVP 368
+ R +A V N ++ +GG + D + V YDP N+W M
Sbjct: 371 VVASMSTRRARVGVAAVGNRLYAVGGYDGTSD-----LATVESYDPVTNTWQPEVSMGTR 425
Query: 369 RSEFAVGVIGKFIYAVAGRTRDETFYSTERYDITNDKWEFVDPYPVNKYGHEGTVLNNKL 428
RS V + +Y+ G S ERYD W V + L+ L
Sbjct: 426 RSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNL 485
Query: 429 FITGGITSSSTSKQVCVFDPSKEGTIEQRTRRTQVVTNCWENKSKMNYARCFHKMISYNG 488
+ GG SSS V ++P N W + M R + G
Sbjct: 486 YAVGGYDSSSHLATVEKYEPQ---------------VNVWSPVASMLSRRSSAGVAVLEG 530
Query: 489 KLYVFGGVCVILRASFESQGC-PSTEVYNPETDQWTILASMPIGRSGHGVTVLDKQIMVL 547
LYV GG + C S E Y+P+ W +A M I RS H + +D + +
Sbjct: 531 ALYVAGG--------NDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAV 582
Query: 548 GGLCYNGHYS-DSILTFDPDENKW 570
GG +G S +SI ++P NKW
Sbjct: 583 GG--NDGSSSLNSIEKYNPRTNKW 604
Score = 31.2 bits (69), Expect = 2.9
Identities = 23/91 (25%), Positives = 39/91 (42%), Gaps = 5/91 (5%)
Query: 287 GMIGHSMVNSKILLLKKPRVWWELEGPQVPLRPDCLAIVNNFVFLLGGEELGPDGEFHAS 346
G G S +NS K W + + L ++ +++ +GG DG +
Sbjct: 537 GNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGN----DGSSSLN 592
Query: 347 SKVFRYDPRQNSWLQMADMSVPRSEFAVGVI 377
S + +Y+PR N W+ + M RS V V+
Sbjct: 593 S-IEKYNPRTNKWVAASCMFTRRSSVGVAVL 622
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,441,816
Number of Sequences: 37866
Number of extensions: 962630
Number of successful extensions: 3058
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 1877
Number of HSP's gapped (non-prelim): 397
length of query: 604
length of database: 18,247,518
effective HSP length: 108
effective length of query: 496
effective length of database: 14,157,990
effective search space: 7022363040
effective search space used: 7022363040
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.