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Search of human proteins with 223890235
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223890235 intracisternal A particle-promoted polypeptide
isoform 2 [Homo sapiens]
(582 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223890235 intracisternal A particle-promoted polypeptide isof... 1194 0.0
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 1127 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 364 e-100
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 319 4e-87
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 318 7e-87
gi|11056006 kelch-like 12 [Homo sapiens] 312 5e-85
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 311 1e-84
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 311 1e-84
gi|38194229 kelch-like 17 [Homo sapiens] 310 2e-84
gi|14780904 kelch-like 1 protein [Homo sapiens] 305 8e-83
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 303 4e-82
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 303 4e-82
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 300 2e-81
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 300 2e-81
gi|55925604 kelch-like 18 [Homo sapiens] 294 2e-79
gi|166235129 kelch-like 3 [Homo sapiens] 292 7e-79
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 291 1e-78
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 282 7e-76
gi|34101268 kelch-like 8 [Homo sapiens] 275 6e-74
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 260 2e-69
gi|148664209 kelch-like 10 [Homo sapiens] 253 3e-67
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 240 3e-63
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 233 3e-61
gi|24308181 kelch-like 9 [Homo sapiens] 216 6e-56
gi|40018614 DRE1 protein [Homo sapiens] 214 2e-55
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 213 3e-55
gi|45643138 kelch-like 13 [Homo sapiens] 212 7e-55
gi|24432026 kelch-like [Homo sapiens] 212 7e-55
gi|55925608 kelch-like 21 [Homo sapiens] 207 2e-53
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 204 2e-52
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 1194 bits (3090), Expect = 0.0
Identities = 582/582 (100%), Positives = 582/582 (100%)
Query: 1 MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP 60
MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP
Sbjct: 1 MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP 60
Query: 61 YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT 120
YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT
Sbjct: 61 YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT 120
Query: 121 EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK 180
EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK
Sbjct: 121 EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK 180
Query: 181 DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI
Sbjct: 181 DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
Query: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ
Sbjct: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
Query: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
Query: 361 ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV
Sbjct: 361 ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
Query: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV
Sbjct: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
Query: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG
Sbjct: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Query: 541 RSSSHDFLAPDTHRYEVFRLKWENMCILFNDHKTLTKGIFNL 582
RSSSHDFLAPDTHRYEVFRLKWENMCILFNDHKTLTKGIFNL
Sbjct: 541 RSSSHDFLAPDTHRYEVFRLKWENMCILFNDHKTLTKGIFNL 582
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 1127 bits (2914), Expect = 0.0
Identities = 551/552 (99%), Positives = 551/552 (99%)
Query: 1 MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP 60
MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP
Sbjct: 1 MANEDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSP 60
Query: 61 YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT 120
YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT
Sbjct: 61 YFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLT 120
Query: 121 EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK 180
EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK
Sbjct: 121 EVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTK 180
Query: 181 DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI
Sbjct: 181 DQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
Query: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ
Sbjct: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
Query: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT
Sbjct: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
Query: 361 ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV
Sbjct: 361 ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
Query: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV
Sbjct: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
Query: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG
Sbjct: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
Query: 541 RSSSHDFLAPDT 552
RSSSHDFLAP T
Sbjct: 541 RSSSHDFLAPGT 552
Score = 56.6 bits (135), Expect = 6e-08
Identities = 33/104 (31%), Positives = 50/104 (48%), Gaps = 13/104 (12%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+Y+VGG+ Q AL VE++ + W V+S+ R+G+ V + G++Y G
Sbjct: 487 IYSVGGWNETQD-------ALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSG 539
Query: 350 GEKDSMIF------DCTECYDPVTKQWTTVASMNHPRCGLGVCV 387
G S F D E Y+P + WT + +M RC GV V
Sbjct: 540 GRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAV 583
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 364 bits (934), Expect = e-100
Identities = 207/540 (38%), Positives = 302/540 (55%), Gaps = 16/540 (2%)
Query: 4 EDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFA 63
E P+ A P+ SDKH + L IN +R + CDV L VG + AHR++L+A SPYF
Sbjct: 35 EGVPQPARMPYISDKHPRQTLEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFR 94
Query: 64 ALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVV 123
A+FTG + ES + V I I+ ++L+DF YT + + NVQ L+ AA +LQL E+
Sbjct: 95 AMFTGELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQ 154
Query: 124 HLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQL 183
CCEFLK Q+DP NC+GI F++ +C +LL ++ + +F EV EEF+ L +QL
Sbjct: 155 EACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQL 214
Query: 184 IKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGV 243
I I+ S+EL++ E QVF A M W+ + +RR + +VL +R PLL P+ L+ +
Sbjct: 215 IDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSD 274
Query: 244 SDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKAR--KYLYAVGGYTRLQG 301
+ L+ E P+E +Q + RPRK R + L+AVGG
Sbjct: 275 PLIKSDEECRDLVDEAKNYLLLPQER---PLMQGPRTRPRKPIRCGEVLFAVGG------ 325
Query: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
W A+S VER+D + W V+S+ + R G+GV+VL ++YA+GG S + E
Sbjct: 326 --WCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVE 383
Query: 362 CYDPVTKQWTT-VASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVV 420
YDP T QW++ VA + R +GV V G +YA+GG G N +ER+DP ENKW V
Sbjct: 384 RYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRV 443
Query: 421 GNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGV 480
+M+ R + G +Y +GG S+ L + E Y+P RW + PMGTRR +LG
Sbjct: 444 ASMSTRRLGVAVAVLGGFLYAVGG-SDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGC 502
Query: 481 AALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
A D IY+VGG ++T + L + E+Y+ +W V +M R+G+ + VNG L GG
Sbjct: 503 AVYQDMIYAVGGRDDTTE-LSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGG 561
Score = 96.7 bits (239), Expect = 5e-20
Identities = 60/166 (36%), Positives = 81/166 (48%), Gaps = 13/166 (7%)
Query: 266 PKENKFCSFLQTSKVRPRKKARK---YLYAVGGYTRLQGGRWSDSRA-LSCVERFDTFSQ 321
PKENK+ S R +LYAVGG SD + L+ VER++
Sbjct: 435 PKENKWTRVASMSTRRLGVAVAVLGGFLYAVGG---------SDGTSPLNTVERYNPQEN 485
Query: 322 YWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRC 381
W T++ + R LG V M+YA+GG D+ E Y+P T QW+ V +M R
Sbjct: 486 RWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRS 545
Query: 382 GLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSR 427
G+G+ V G + A+GG+ G TIE FDPD N W + G M R
Sbjct: 546 GVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRR 591
Score = 59.7 bits (143), Expect = 7e-09
Identities = 37/126 (29%), Positives = 58/126 (46%), Gaps = 11/126 (8%)
Query: 265 SPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQ 321
+P+EN++ + R Y +YAVGG D+ LS ER++ +
Sbjct: 481 NPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR--------DDTTELSSAERYNPRTN 532
Query: 322 YWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRC 381
W+ V ++ RSG+G+ V+ G + A+GG + E +DP W MN+ R
Sbjct: 533 QWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRL 592
Query: 382 GLGVCV 387
G GV V
Sbjct: 593 GGGVGV 598
Score = 45.4 bits (106), Expect = 1e-04
Identities = 23/60 (38%), Positives = 36/60 (60%), Gaps = 1/60 (1%)
Query: 485 DCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
+ +++VGGW + DA+ +VE+Y + +W VASM R G+ V ++ LLY GG S
Sbjct: 318 EVLFAVGGWC-SGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGS 376
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 319 bits (818), Expect = 4e-87
Identities = 192/574 (33%), Positives = 296/574 (51%), Gaps = 21/574 (3%)
Query: 10 ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69
++ F HA+ L ++ + CDV L G AHRLVL+A S YFAA+FT
Sbjct: 155 SEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTND 214
Query: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
+ E+ ++ V + G++ L+ + YTG++ + + ++ L+ AA +LQLT+V+ +C F
Sbjct: 215 VLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNF 274
Query: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
L Q+ P NC+GI F + C +LL + Y HF+EV +EFL L +++ K+L S
Sbjct: 275 LIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCS 334
Query: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
+++++ DE +F A MQW+ D+ R+ + +L IR PLLPPQ LL +E S F
Sbjct: 335 DDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGD 393
Query: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
+ Q LL E + P+ S +Q+ + +PRK LYAVGG ++G
Sbjct: 394 LECQKLLMEAMKYHLLPERR---SMMQSPRTKPRKSTVGALYAVGGMDAMKG-------- 442
Query: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
+ +E++D + W + +++ R GV V+ +Y +GG + EC++PV K
Sbjct: 443 TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKI 502
Query: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429
WT + M+ R GLGV G +YA+GG G NT+ER+DP+ +W V +M+ R
Sbjct: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRST 562
Query: 430 FGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYS 489
G + +Y IGG L+S E +DP + +WS PM RR +GVA N +Y
Sbjct: 563 VGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYV 621
Query: 490 VGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
VGG N VE+Y + + W VA + VPR + V + LYV GG
Sbjct: 622 VGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDG 680
Query: 545 HDFLAPDTHRYEVFRLKW-ENMCILFNDHKTLTK 577
H +L Y+ R +W E+M L + T K
Sbjct: 681 HTYL-NTVESYDAQRNEWKESMQELLQNFYTTQK 713
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 318 bits (816), Expect = 7e-87
Identities = 187/559 (33%), Positives = 290/559 (51%), Gaps = 20/559 (3%)
Query: 10 ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69
++ F HA+ L ++ + CDV L G AHRLVL+A S YFAA+FT
Sbjct: 155 SEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTND 214
Query: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
+ E+ ++ V + G++ L+ + YTG++ + + ++ L+ AA +LQLT+V+ +C F
Sbjct: 215 VLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNF 274
Query: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
L Q+ P NC+GI F + C +LL + Y HF+EV +EFL L +++ K+L S
Sbjct: 275 LIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCS 334
Query: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
+++++ DE +F A MQW+ D+ R+ + +L IR PLLPPQ LL +E S F
Sbjct: 335 DDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSMFTGD 393
Query: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
+ Q LL E + P+ S +Q+ + +PRK LYAVGG ++G
Sbjct: 394 LECQKLLMEAMKYHLLPERR---SMMQSPRTKPRKSTVGALYAVGGMDAMKG-------- 442
Query: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
+ +E++D + W + +++ R GV V+ +Y +GG + EC++PV K
Sbjct: 443 TTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKI 502
Query: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429
WT + M+ R GLGV G +YA+GG G NT+ER+DP+ +W V +M+ R
Sbjct: 503 WTVMPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRST 562
Query: 430 FGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYS 489
G + +Y IGG L+S E +DP + +WS PM RR +GVA N +Y
Sbjct: 563 VGVVALNNKLYAIGGRDGSSC-LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYV 621
Query: 490 VGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
VGG N VE+Y + + W VA + VPR + V + LYV GG
Sbjct: 622 VGGHDAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGG-YDG 680
Query: 545 HDFLAPDTHRYEVFRLKWE 563
H +L Y+ R +W+
Sbjct: 681 HTYL-NTVESYDAQRNEWK 698
Score = 55.5 bits (132), Expect = 1e-07
Identities = 32/99 (32%), Positives = 43/99 (43%), Gaps = 2/99 (2%)
Query: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
+LY VGG+ S R CVER+D W+TV+ L R + V LG +Y +
Sbjct: 618 FLYVVGGHDAPASNHCS--RLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVV 675
Query: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387
GG + E YD +W +N R G V V
Sbjct: 676 GGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAGACVVV 714
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 312 bits (800), Expect = 5e-85
Identities = 186/534 (34%), Positives = 280/534 (52%), Gaps = 15/534 (2%)
Query: 10 ADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGG 69
A ++ HA+ IL +N +R CDV L+V Q+ F AHR+VLAA S YF A+FT
Sbjct: 6 APKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSE 65
Query: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
+ E K V I G+ A +ILLDF+YT V++ V NVQEL+ AA +LQL V CCEF
Sbjct: 66 LSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEF 125
Query: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
L+ Q+DP NC+GI F+E C DL++ +E + HF EV EEF+ L++ ++ K+++
Sbjct: 126 LESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKC 185
Query: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
+E+ ++ E VF A + W+ +R + + +L +R PLL P+ + I+
Sbjct: 186 DEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCS 245
Query: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
+ + L+ E + P + S +Q + R R A + L VGG+ S
Sbjct: 246 LQCRDLVDEAKKFHLRP---ELRSQMQGPRTRARLGANEVLLVVGGF-------GSQQSP 295
Query: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
+ VE++D +Q W+ + S+ + R + L +Y IGG EC D +
Sbjct: 296 IDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADE 355
Query: 370 ---WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
W +VA MN R G IY GG+ G+ ++ER+DP+ ++W ++G+M +
Sbjct: 356 DGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTA 415
Query: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
R G G+IY +GG I L S E YDP + W+ + PM T+R+ GVA LND
Sbjct: 416 REGAGLVVASGVIYCLGGYDGLNI-LNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDH 474
Query: 487 IYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
IY VGG++ T L +VE Y+ + W V SM PR + + G LY G
Sbjct: 475 IYVVGGFDGTAH-LSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG 527
Score = 114 bits (284), Expect = 3e-25
Identities = 60/184 (32%), Positives = 90/184 (48%), Gaps = 1/184 (0%)
Query: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
G + SR + +ER+D W+ + + AR G G+ V G++Y +GG I + E
Sbjct: 385 GGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVE 444
Query: 362 CYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVG 421
YDP T WT V M R G GV + IY +GG+ G +++E ++ + W V
Sbjct: 445 KYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVT 504
Query: 422 NMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVA 481
+M R Y G ++G +Y I G + L S E YDP+ W + MGT+R GV
Sbjct: 505 SMTTPRCYVGATVLRGRLYAIAGYDGNSL-LSSIECYDPIIDSWEVVTSMGTQRCDAGVC 563
Query: 482 ALND 485
L +
Sbjct: 564 VLRE 567
Score = 100 bits (248), Expect = 5e-21
Identities = 52/147 (35%), Positives = 78/147 (53%), Gaps = 8/147 (5%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+Y +GGY L L+ VE++D + +WT V+ + RSG GV +L +Y +G
Sbjct: 428 IYCLGGYDGLN--------ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVG 479
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
G + E Y+ T WTTV SM PRC +G V G +YA+ G+ G + ++IE
Sbjct: 480 GFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIEC 539
Query: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQ 436
+DP + WEVV +M R G C ++
Sbjct: 540 YDPIIDSWEVVTSMGTQRCDAGVCVLR 566
Score = 61.2 bits (147), Expect = 2e-09
Identities = 35/110 (31%), Positives = 58/110 (52%), Gaps = 4/110 (3%)
Query: 438 LIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
++ V+GG ++ + E YDP ++ WS LP + +R Y+ +L+D IY +GG+ + +
Sbjct: 282 VLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGGY-DGR 340
Query: 498 DALHTVEKYSF---EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
L +VE + E+ W VA M V R + ++YVSGG S
Sbjct: 341 SRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGS 390
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 311 bits (797), Expect = 1e-84
Identities = 178/539 (33%), Positives = 281/539 (52%), Gaps = 18/539 (3%)
Query: 7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALF 66
P +D F + HA+ ++ + CDV L G AHRLVL++ S YFAA+F
Sbjct: 144 PCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMF 203
Query: 67 TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126
T ++E+ ++ + + G+E L+ + YTG + + +N++ L+ A +LQL++VV C
Sbjct: 204 TNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEAC 263
Query: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186
C+FL Q+ P NC+GI F++ C DL + + NY HF+EV +EF+ L ++ K+
Sbjct: 264 CKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKL 323
Query: 187 LRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDF 246
L S++++I +E + A + W+ DL +RRK + ++L IR PLL PQ L +E F
Sbjct: 324 LASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQ-FLADMENNVLF 382
Query: 247 NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSD 306
+ Q L+ E + P+ LQ+ + +PRK L+AVGG +G
Sbjct: 383 RDDIECQKLIMEAMKYHLLPERR---PMLQSPRTKPRKSTVGTLFAVGGMDSTKGA---- 435
Query: 307 SRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPV 366
+ +E++D + WT V++++ R GV VL +Y +GG + ECY+P
Sbjct: 436 ----TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPK 491
Query: 367 TKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
TK W+ + M+ R GLGV V G +YA+GG G NT+ER+DP +W V M+
Sbjct: 492 TKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTP 551
Query: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
R G + G +Y +GG L+S E +DP + +W+ M RR +GV N
Sbjct: 552 RSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 610
Query: 487 IYSVGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
+Y++GG N T VE+Y + + W VASM + R + V + LY GG
Sbjct: 611 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG 669
Score = 124 bits (311), Expect = 2e-28
Identities = 67/193 (34%), Positives = 104/193 (53%), Gaps = 15/193 (7%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+YAVGG+ WS L+ VER+D ++ W V+++ RS +GV VL G +YA+G
Sbjct: 517 MYAVGGHDG-----WS---YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVG 568
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGW------VGAEI 403
G S EC+DP T +WT A M+ R G+GV G +YA+GG + + +
Sbjct: 569 GRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 628
Query: 404 GNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSK 463
+ +ER+DP + W V +M++SR G C + +Y +GG + L + E YDP +
Sbjct: 629 SDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAY-LNTVEAYDPQTN 687
Query: 464 RWSPLPPMGTRRA 476
W+ + P+ RA
Sbjct: 688 EWTQVAPLCLGRA 700
Score = 106 bits (265), Expect = 5e-23
Identities = 59/156 (37%), Positives = 90/156 (57%), Gaps = 4/156 (2%)
Query: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449
G ++A+GG + +IE++D N W V NM R FG + +YV+GG +G
Sbjct: 421 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG--RDG 478
Query: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
++ L + E Y+P +K WS +PPM T R LGVA L +Y+VGG ++ L+TVE++
Sbjct: 479 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDP 537
Query: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
+ +W VA+M PR+ + V ++G LY GGR S
Sbjct: 538 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS 573
Score = 73.9 bits (180), Expect = 4e-13
Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 5/123 (4%)
Query: 263 CKSPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTF 319
C P NK+ Q SK R + LYA+GG+ SR CVER+D
Sbjct: 581 CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL--TSRLSDCVERYDPK 638
Query: 320 SQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHP 379
+ WT V+S+ +R +GV +LG +YA+GG + E YDP T +WT VA +
Sbjct: 639 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 698
Query: 380 RCG 382
R G
Sbjct: 699 RAG 701
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 311 bits (797), Expect = 1e-84
Identities = 178/539 (33%), Positives = 281/539 (52%), Gaps = 18/539 (3%)
Query: 7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALF 66
P +D F + HA+ ++ + CDV L G AHRLVL++ S YFAA+F
Sbjct: 190 PCTSDEFFQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMF 249
Query: 67 TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126
T ++E+ ++ + + G+E L+ + YTG + + +N++ L+ A +LQL++VV C
Sbjct: 250 TNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEAC 309
Query: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186
C+FL Q+ P NC+GI F++ C DL + + NY HF+EV +EF+ L ++ K+
Sbjct: 310 CKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKL 369
Query: 187 LRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDF 246
L S++++I +E + A + W+ DL +RRK + ++L IR PLL PQ L +E F
Sbjct: 370 LASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQ-FLADMENNVLF 428
Query: 247 NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSD 306
+ Q L+ E + P+ LQ+ + +PRK L+AVGG +G
Sbjct: 429 RDDIECQKLIMEAMKYHLLPERR---PMLQSPRTKPRKSTVGTLFAVGGMDSTKGA---- 481
Query: 307 SRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPV 366
+ +E++D + WT V++++ R GV VL +Y +GG + ECY+P
Sbjct: 482 ----TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPK 537
Query: 367 TKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVS 426
TK W+ + M+ R GLGV V G +YA+GG G NT+ER+DP +W V M+
Sbjct: 538 TKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTP 597
Query: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
R G + G +Y +GG L+S E +DP + +W+ M RR +GV N
Sbjct: 598 RSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 656
Query: 487 IYSVGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
+Y++GG N T VE+Y + + W VASM + R + V + LY GG
Sbjct: 657 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGG 715
Score = 124 bits (311), Expect = 2e-28
Identities = 67/193 (34%), Positives = 104/193 (53%), Gaps = 15/193 (7%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+YAVGG+ WS L+ VER+D ++ W V+++ RS +GV VL G +YA+G
Sbjct: 563 MYAVGGHDG-----WS---YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVG 614
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGW------VGAEI 403
G S EC+DP T +WT A M+ R G+GV G +YA+GG + + +
Sbjct: 615 GRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 674
Query: 404 GNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSK 463
+ +ER+DP + W V +M++SR G C + +Y +GG + L + E YDP +
Sbjct: 675 SDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAY-LNTVEAYDPQTN 733
Query: 464 RWSPLPPMGTRRA 476
W+ + P+ RA
Sbjct: 734 EWTQVAPLCLGRA 746
Score = 106 bits (265), Expect = 5e-23
Identities = 59/156 (37%), Positives = 90/156 (57%), Gaps = 4/156 (2%)
Query: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449
G ++A+GG + +IE++D N W V NM R FG + +YV+GG +G
Sbjct: 467 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG--RDG 524
Query: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
++ L + E Y+P +K WS +PPM T R LGVA L +Y+VGG ++ L+TVE++
Sbjct: 525 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDP 583
Query: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
+ +W VA+M PR+ + V ++G LY GGR S
Sbjct: 584 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS 619
Score = 73.9 bits (180), Expect = 4e-13
Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 5/123 (4%)
Query: 263 CKSPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTF 319
C P NK+ Q SK R + LYA+GG+ SR CVER+D
Sbjct: 627 CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL--TSRLSDCVERYDPK 684
Query: 320 SQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHP 379
+ WT V+S+ +R +GV +LG +YA+GG + E YDP T +WT VA +
Sbjct: 685 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 744
Query: 380 RCG 382
R G
Sbjct: 745 RAG 747
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 310 bits (795), Expect = 2e-84
Identities = 188/572 (32%), Positives = 291/572 (50%), Gaps = 21/572 (3%)
Query: 15 SSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESS 74
+S +H +++MR CD+ L V + +AH++VLA+ SPYF A+FT M ES
Sbjct: 70 NSKRHYHDAFVAMSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESR 129
Query: 75 KDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQI 134
+ V + I+ L+ F YT + +G NVQ L+ AA +LQL V CC+FL Q+
Sbjct: 130 QTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQL 189
Query: 135 DPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSI 194
DP NC+GI F++ +C DLL+ + Y+ HF++V EEF+ L Q+++++ S+ L++
Sbjct: 190 DPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNV 249
Query: 195 EDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQT 254
E +V+ A + W+ D+ RR+HV ++ +R PLL LL +++ S +
Sbjct: 250 PSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKD 309
Query: 255 LLKEYCEVCKSPKENKFCSFLQTSKVRPRK--KARKYLYAVGGYT--RLQGGRWSDSRAL 310
LL E + P++ L TS+ RPR+ A L+AVGG + + G
Sbjct: 310 LLIEALKFHLLPEQR---GVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGD-------- 358
Query: 311 SCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQW 370
E +DT + W V+S+ R+ +GV +G +YA+GG + E YDPVT W
Sbjct: 359 --CEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTW 416
Query: 371 TTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYF 430
SM R LGV +G +Y+ GG+ GA N+ ER+DP W V M+ R Y
Sbjct: 417 QPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYV 476
Query: 431 GCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSV 490
+ G +Y +GG + L + E Y+P WSP+ M +RR+ GVA L +Y
Sbjct: 477 RVATLDGNLYAVGGYDSSS-HLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVA 535
Query: 491 GGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAP 550
GG N+ L++VE+YS + W VA M + R+ +VA++G LY GG S
Sbjct: 536 GG-NDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSL--N 592
Query: 551 DTHRYEVFRLKWENMCILFNDHKTLTKGIFNL 582
+Y KW +F ++ + L
Sbjct: 593 SIEKYNPRTNKWVAASCMFTRRSSVGVAVLEL 624
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 305 bits (781), Expect = 8e-83
Identities = 175/527 (33%), Positives = 277/527 (52%), Gaps = 18/527 (3%)
Query: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
HA+ ++ Q CDV L VG AHRLVL++ S YFAA+FT + E+ ++ +
Sbjct: 194 HAEQTFRKMESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEI 253
Query: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
+ GI+ L+ F YTG + + + ++ L+ AA +LQL +VV +CC FL + P N
Sbjct: 254 KMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSN 313
Query: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
C+GI F++ C +L++ + +Y + +EV +EFL L ++L K+L S+++++ DE
Sbjct: 314 CLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEE 373
Query: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
+F A M W+ D+ R + +L IR PLLPPQ +L +E + F + Q L+ E
Sbjct: 374 TIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQ-ILADLENHALFKNDLECQKLILE 432
Query: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
+ P+ + +Q+ + +PRK LYAVGG +++ + +E++D
Sbjct: 433 AMKYHLLPERR---TLMQSPRTKPRKSTVGTLYAVGG--------MDNNKGATTIEKYDL 481
Query: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH 378
+ W ++ R GV V+ ++ IGG + ECY+P TK WT + M+
Sbjct: 482 RTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMST 541
Query: 379 PRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGL 438
R GLGV V G IYA+GG G NT+ER+DP +W V +M+++R G + G
Sbjct: 542 HRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGK 601
Query: 439 IYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGW----- 493
+Y +GG L S E YDP + +W+ PM RR +GVA + +Y+VGG
Sbjct: 602 LYSVGGRDGSSC-LSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPAS 660
Query: 494 NETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
N L VE+Y + + W VA + +PR + V + LY GG
Sbjct: 661 NHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG 707
Score = 109 bits (273), Expect = 6e-24
Identities = 68/178 (38%), Positives = 97/178 (54%), Gaps = 7/178 (3%)
Query: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449
G +YA+GG + TIE++D N W G M R FG + ++VIGG +G
Sbjct: 459 GTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGG--RDG 516
Query: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
++ L + E Y+P +K W+ LPPM T R LGV L IY+VGG ++ L+TVE++
Sbjct: 517 LKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGG-HDGWSYLNTVERWDP 575
Query: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYEVFRLKWENMC 566
+ ++W VASM + R+ + V A+NG LY GGR S Y+ KW NMC
Sbjct: 576 QSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSS--CLSSMEYYDPHTNKW-NMC 630
Score = 91.7 bits (226), Expect = 2e-18
Identities = 49/142 (34%), Positives = 74/142 (52%), Gaps = 7/142 (4%)
Query: 292 AVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE 351
A+ G GGR S LS +E +D + W + + + R G+GV G +YA+GG
Sbjct: 597 ALNGKLYSVGGR-DGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGH 655
Query: 352 KD------SMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGN 405
S + D E YDP T WT VA ++ PR +GVC+ +YA+GG+ G N
Sbjct: 656 DAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLN 715
Query: 406 TIERFDPDENKWEVVGNMAVSR 427
T+E +DP N+W + ++ + R
Sbjct: 716 TMESYDPQTNEWTQMASLNIGR 737
Score = 73.2 bits (178), Expect = 6e-13
Identities = 40/99 (40%), Positives = 53/99 (53%), Gaps = 2/99 (2%)
Query: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
+LYAVGG+ S R L VER+D + WT V+ L R +GV +LG +YA+
Sbjct: 648 FLYAVGGHDAPASNHCS--RLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAV 705
Query: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387
GG + E YDP T +WT +AS+N R G V V
Sbjct: 706 GGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVV 744
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 303 bits (775), Expect = 4e-82
Identities = 190/574 (33%), Positives = 297/574 (51%), Gaps = 57/574 (9%)
Query: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQES-----FKAHRLVLAASSPYFAALFTG 68
++ + H + +N++R Q CDV LQV + F AH++VLA+SSP F A+FT
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 69 GMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCE 128
G++E +VV I GI + + L++F YT +++G V ++ A M Q+ VV C +
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 129 FLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILR 188
FL Q+DP N IGI F+EQI C +L + + YI++HF EV EEF L+ QL+ ++
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
Query: 189 SEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQ---------RLLKY 239
++L++ E +VF A + W+ D +RR +V +L +R L P +L+
Sbjct: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
Query: 240 IEGVSDFNLRVALQTLLKEYCEV--CKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYT 297
D+ +++ + L + +V C++PK + +Y GGY
Sbjct: 294 DSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRL------------------IYTAGGYF 335
Query: 298 RLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDS--- 354
R ++LS +E ++ W ++ L RSGL V+GG++YA+GG +S
Sbjct: 336 R---------QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 355 -MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPD 413
+CY+P+T QW+ A M+ PR +GV V G IYA+GG G N++ER++P+
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473
++W +V M R G + L+Y +GG L S E Y P W + M T
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEWRMITAMNT 505
Query: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
R+ GV L++CIY+ GG+ + QD L++VE+Y E E W VA MK R+ + + G
Sbjct: 506 IRSGAGVCVLHNCIYAAGGY-DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
Query: 534 LLYVSGGRSSSHDFL------APDTHRY-EVFRL 560
+YV GG H FL PDT + EV R+
Sbjct: 565 RIYVLGG-YDGHTFLDSVECYDPDTDTWSEVTRM 597
Score = 86.7 bits (213), Expect = 6e-17
Identities = 49/140 (35%), Positives = 69/140 (49%), Gaps = 8/140 (5%)
Query: 288 KYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYA 347
+ LYAVGG+ + L+ E + W +++++ RSG GV VL +YA
Sbjct: 470 RLLYAVGGF--------DGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYA 521
Query: 348 IGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTI 407
GG + E YD T+ WT VA M H R LG+ V G IY LGG+ G +++
Sbjct: 522 AGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSV 581
Query: 408 ERFDPDENKWEVVGNMAVSR 427
E +DPD + W V M R
Sbjct: 582 ECYDPDTDTWSEVTRMTSGR 601
Score = 74.3 bits (181), Expect = 3e-13
Identities = 38/98 (38%), Positives = 50/98 (51%), Gaps = 8/98 (8%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+YA GGY L+ VER+D ++ WT V+ + RS LG+TV G +Y +G
Sbjct: 519 IYAAGGY--------DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLG 570
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387
G D ECYDP T W+ V M R G+GV V
Sbjct: 571 GYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 303 bits (775), Expect = 4e-82
Identities = 190/574 (33%), Positives = 297/574 (51%), Gaps = 57/574 (9%)
Query: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQES-----FKAHRLVLAASSPYFAALFTG 68
++ + H + +N++R Q CDV LQV + F AH++VLA+SSP F A+FT
Sbjct: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Query: 69 GMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCE 128
G++E +VV I GI + + L++F YT +++G V ++ A M Q+ VV C +
Sbjct: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
Query: 129 FLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILR 188
FL Q+DP N IGI F+EQI C +L + + YI++HF EV EEF L+ QL+ ++
Sbjct: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
Query: 189 SEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQ---------RLLKY 239
++L++ E +VF A + W+ D +RR +V +L +R L P +L+
Sbjct: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
Query: 240 IEGVSDFNLRVALQTLLKEYCEV--CKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYT 297
D+ +++ + L + +V C++PK + +Y GGY
Sbjct: 294 DSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRL------------------IYTAGGYF 335
Query: 298 RLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDS--- 354
R ++LS +E ++ W ++ L RSGL V+GG++YA+GG +S
Sbjct: 336 R---------QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
Query: 355 -MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPD 413
+CY+P+T QW+ A M+ PR +GV V G IYA+GG G N++ER++P+
Sbjct: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
Query: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473
++W +V M R G + L+Y +GG L S E Y P W + M T
Sbjct: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEWRMITAMNT 505
Query: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
R+ GV L++CIY+ GG+ + QD L++VE+Y E E W VA MK R+ + + G
Sbjct: 506 IRSGAGVCVLHNCIYAAGGY-DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
Query: 534 LLYVSGGRSSSHDFL------APDTHRY-EVFRL 560
+YV GG H FL PDT + EV R+
Sbjct: 565 RIYVLGG-YDGHTFLDSVECYDPDTDTWSEVTRM 597
Score = 86.7 bits (213), Expect = 6e-17
Identities = 49/140 (35%), Positives = 69/140 (49%), Gaps = 8/140 (5%)
Query: 288 KYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYA 347
+ LYAVGG+ + L+ E + W +++++ RSG GV VL +YA
Sbjct: 470 RLLYAVGGF--------DGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYA 521
Query: 348 IGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTI 407
GG + E YD T+ WT VA M H R LG+ V G IY LGG+ G +++
Sbjct: 522 AGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSV 581
Query: 408 ERFDPDENKWEVVGNMAVSR 427
E +DPD + W V M R
Sbjct: 582 ECYDPDTDTWSEVTRMTSGR 601
Score = 74.3 bits (181), Expect = 3e-13
Identities = 38/98 (38%), Positives = 50/98 (51%), Gaps = 8/98 (8%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+YA GGY L+ VER+D ++ WT V+ + RS LG+TV G +Y +G
Sbjct: 519 IYAAGGY--------DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLG 570
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387
G D ECYDP T W+ V M R G+GV V
Sbjct: 571 GYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 300 bits (768), Expect = 2e-81
Identities = 180/545 (33%), Positives = 284/545 (52%), Gaps = 16/545 (2%)
Query: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
H + +N++R+ CDV + AHR+VLAA SPYF A+FTG M ES V
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 101
Query: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
I ++ ++L+D++YT + + NVQ L+ AA +LQL +V CCEFL+ Q+ P+N
Sbjct: 102 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 161
Query: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
C+GI F++ AC DLL + Y HF +V EEFL L +Q+ ++ S++L+I E
Sbjct: 162 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 221
Query: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
+VF A + W+ D R++ + +++ +R PLLP + L++ +E + A + L E
Sbjct: 222 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 281
Query: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
+ P E + +++R K + VGG +A+ VE +D
Sbjct: 282 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA---------PKAIRSVECYDF 332
Query: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH 378
+ W V+ L R G+ + G+V+A+GG S+ + YDPV QWT+VA+M
Sbjct: 333 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 392
Query: 379 PRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGL 438
R LG V G +YA+GG+ G+ +++E ++ N+W V M R G + GL
Sbjct: 393 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 452
Query: 439 IYVIGGISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
+Y +GG + L + E Y+ + W+ + M TRR+ GV LN+ +Y+VGG ++
Sbjct: 453 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-HDGP 511
Query: 498 DALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG-----RSSSHDFLAPDT 552
+VE Y W +VA M + R V AVNGLLYV GG +S ++ P T
Sbjct: 512 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTT 571
Query: 553 HRYEV 557
++ V
Sbjct: 572 DKWTV 576
Score = 95.9 bits (237), Expect = 9e-20
Identities = 53/143 (37%), Positives = 76/143 (53%), Gaps = 7/143 (4%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
LYAVGGY + + LS VE ++ + WT ++ + RSG GV VL ++YA+G
Sbjct: 453 LYAVGGYDG------ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVG 506
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
G ++ E YDP T W VA MN R GVC G +Y +GG G+ ++E
Sbjct: 507 GHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEY 566
Query: 410 FDPDENKWEVVGN-MAVSRYYFG 431
++P +KW VV + M+ R Y G
Sbjct: 567 YNPTTDKWTVVSSCMSTGRSYAG 589
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 300 bits (768), Expect = 2e-81
Identities = 180/545 (33%), Positives = 284/545 (52%), Gaps = 16/545 (2%)
Query: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
H + +N++R+ CDV + AHR+VLAA SPYF A+FTG M ES V
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRV 97
Query: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
I ++ ++L+D++YT + + NVQ L+ AA +LQL +V CCEFL+ Q+ P+N
Sbjct: 98 RIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVN 157
Query: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
C+GI F++ AC DLL + Y HF +V EEFL L +Q+ ++ S++L+I E
Sbjct: 158 CLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEE 217
Query: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
+VF A + W+ D R++ + +++ +R PLLP + L++ +E + A + L E
Sbjct: 218 KVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIE 277
Query: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
+ P E + +++R K + VGG +A+ VE +D
Sbjct: 278 AMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA---------PKAIRSVECYDF 328
Query: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNH 378
+ W V+ L R G+ + G+V+A+GG S+ + YDPV QWT+VA+M
Sbjct: 329 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRD 388
Query: 379 PRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGL 438
R LG V G +YA+GG+ G+ +++E ++ N+W V M R G + GL
Sbjct: 389 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448
Query: 439 IYVIGGISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
+Y +GG + L + E Y+ + W+ + M TRR+ GV LN+ +Y+VGG ++
Sbjct: 449 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG-HDGP 507
Query: 498 DALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG-----RSSSHDFLAPDT 552
+VE Y W +VA M + R V AVNGLLYV GG +S ++ P T
Sbjct: 508 LVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTT 567
Query: 553 HRYEV 557
++ V
Sbjct: 568 DKWTV 572
Score = 95.9 bits (237), Expect = 9e-20
Identities = 53/143 (37%), Positives = 76/143 (53%), Gaps = 7/143 (4%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
LYAVGGY + + LS VE ++ + WT ++ + RSG GV VL ++YA+G
Sbjct: 449 LYAVGGYDG------ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVG 502
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
G ++ E YDP T W VA MN R GVC G +Y +GG G+ ++E
Sbjct: 503 GHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEY 562
Query: 410 FDPDENKWEVVGN-MAVSRYYFG 431
++P +KW VV + M+ R Y G
Sbjct: 563 YNPTTDKWTVVSSCMSTGRSYAG 585
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 294 bits (752), Expect = 2e-79
Identities = 175/517 (33%), Positives = 271/517 (52%), Gaps = 16/517 (3%)
Query: 27 INKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAG 86
+ ++R CDV L++G F AHR+VLAAS PYF A+FT M E +D + + G++
Sbjct: 28 MEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMDPS 87
Query: 87 IFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFS 146
+ L++F Y G + I NVQ L++ A LQL + CC FL+ ++ P NC+G+ QF+
Sbjct: 88 ALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQFA 147
Query: 147 EQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQ 206
E + C L + + ++IH HF+EV EEFLAL + +++++ +EL+++ E QVF AA+
Sbjct: 148 ETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAALA 207
Query: 207 WILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSP 266
W+ D +R ++ E+L IR PL PQ L ++ + L+ E + P
Sbjct: 208 WVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHLMP 267
Query: 267 KENKFCSFLQTSKVRPR--KKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWT 324
+ L + RPR +YAVGG S +L+ VE FD + W
Sbjct: 268 ERR---PHLPAFRTRPRCCTSIAGLIYAVGGLN-------SAGDSLNVVEVFDPIANCWE 317
Query: 325 TVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLG 384
+ ARS +GV V+ G++YAIGG + E Y+P T WT V SMN R +G
Sbjct: 318 RCRPMTTARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMG 377
Query: 385 VCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGG 444
V G IY GG+ G +++E + P+ +KW VV +M+ +R G +G IYV GG
Sbjct: 378 TVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGG 437
Query: 445 ISNEGIEL-RSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTV 503
++G+++ S E Y+ + W P M +R G A+L ++ GG+ + L
Sbjct: 438 --HDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY-DGSGFLSIA 494
Query: 504 EKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
E YS ++W + M R+ + +VA G LY GG
Sbjct: 495 EMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGG 531
Score = 102 bits (255), Expect = 7e-22
Identities = 64/209 (30%), Positives = 97/209 (46%), Gaps = 7/209 (3%)
Query: 339 TVLGGMVYAIGGEK---DSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYAL 395
T + G++YA+GG DS+ + E +DP+ W M R +GV V G +YA+
Sbjct: 284 TSIAGLIYAVGGLNSAGDSL--NVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAI 341
Query: 396 GGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSF 455
GG+ G +T+E ++P+ + W VG+M R G + G IYV GG L S
Sbjct: 342 GGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNS-SLSSV 400
Query: 456 EVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVE 515
E Y P + +W+ + M + R+ GV IY GG + Q +VE Y+ W
Sbjct: 401 ETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQ-IFSSVEHYNHHTATWHP 459
Query: 516 VASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
A M R ++ ++V GG S
Sbjct: 460 AAGMLNKRCRHGAASLGSKMFVCGGYDGS 488
Score = 99.4 bits (246), Expect = 8e-21
Identities = 67/216 (31%), Positives = 104/216 (48%), Gaps = 16/216 (7%)
Query: 351 EKDSMIFDCTECYDPV--TKQWTTV--------ASMNHPRCGLGVCVCYGAIYALGGWVG 400
++D ++ C +C D V K + + A PRC + G IYA+GG
Sbjct: 242 QQDDLVRCCHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIA---GLIYAVGGLNS 298
Query: 401 A-EIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYD 459
A + N +E FDP N WE M +R G + GL+Y IGG + + L + E Y+
Sbjct: 299 AGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQ-LRLSTVEAYN 357
Query: 460 PLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASM 519
P + W+ + M ++R+ +G L+ IY GG+ + +L +VE YS E +KW V SM
Sbjct: 358 PETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGY-DGNSSLSSVETYSPETDKWTVVTSM 416
Query: 520 KVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRY 555
R+ V G +YVSGG F + + + +
Sbjct: 417 SSNRSAAGVTVFEGRIYVSGGHDGLQIFSSVEHYNH 452
Score = 93.2 bits (230), Expect = 6e-19
Identities = 49/131 (37%), Positives = 76/131 (58%), Gaps = 6/131 (4%)
Query: 432 CCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVG 491
C + GLIY +GG+++ G L EV+DP++ W PM T R+ +GVA +N +Y++G
Sbjct: 283 CTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIG 342
Query: 492 GWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRS-----SSHD 546
G+ + Q L TVE Y+ E + W V SM R+ M V ++G +YV GG SS +
Sbjct: 343 GY-DGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVE 401
Query: 547 FLAPDTHRYEV 557
+P+T ++ V
Sbjct: 402 TYSPETDKWTV 412
Score = 90.1 bits (222), Expect = 5e-18
Identities = 55/194 (28%), Positives = 84/194 (43%), Gaps = 9/194 (4%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+Y GGY + +LS VE + + WT V+S+ RS GVTV G +Y G
Sbjct: 385 IYVCGGY--------DGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSG 436
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
G IF E Y+ T W A M + RC G ++ GG+ G+ + E
Sbjct: 437 GHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEM 496
Query: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLP 469
+ ++W ++ M R G +Y +GG + L S E+YDP + W+ +
Sbjct: 497 YSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQS-NLSSVEMYDPETDCWTFMA 555
Query: 470 PMGTRRAYLGVAAL 483
PM +GV +
Sbjct: 556 PMACHEGGVGVGCI 569
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 292 bits (747), Expect = 7e-79
Identities = 174/519 (33%), Positives = 266/519 (51%), Gaps = 11/519 (2%)
Query: 27 INKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAG 86
+N++R+ Q CDV + +AHR+VLAA SPYF A+FTG M ES + I ++
Sbjct: 40 MNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQ 99
Query: 87 IFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFS 146
L+D+IYT + + NVQ L+ AA +LQL +V CC+FL+ Q+ P NC+GI F+
Sbjct: 100 TLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAFA 159
Query: 147 EQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQ 206
+ C DLL+ + Y HF EV GEEFL+L+ DQ+ ++ S++L++ E +VF A +
Sbjct: 160 DVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVIS 219
Query: 207 WILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSP 266
WI + R +H+ ++++ +R PLLP L++ +E + + L E + P
Sbjct: 220 WINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLLP 279
Query: 267 KENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTV 326
+ + +K R K + VGG +A+ VE +D W +
Sbjct: 280 LDQRLLIKNPRTKPRTPVSLPKVMIVVGGQA---------PKAIRSVECYDFEEDRWDQI 330
Query: 327 SSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVC 386
+ L R GV + G VYA+GG S+ + YD V QWT++ASM R LG
Sbjct: 331 AELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAA 390
Query: 387 VCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGIS 446
V +YA+GG+ G+ ++E + N+W V M R G ++G +Y +GG
Sbjct: 391 VLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYD 450
Query: 447 NEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEK 505
+ L + E Y+P + W + M TRR+ GV L+ +Y+ GG ++ +VE
Sbjct: 451 GASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGG-HDGPLVRKSVEV 509
Query: 506 YSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
Y W +VA M + R V AVNGLLYV GG S
Sbjct: 510 YDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGS 548
Score = 124 bits (311), Expect = 2e-28
Identities = 72/198 (36%), Positives = 107/198 (54%), Gaps = 12/198 (6%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
LYAVGG+ S L+ VE + + W V+ ++ RS +GV V+ G +YA+G
Sbjct: 396 LYAVGGF--------DGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVG 447
Query: 350 GEKDS--MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTI 407
G + E Y+P T +W VA M+ R G GV V G +YA GG G + ++
Sbjct: 448 GYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSV 507
Query: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSP 467
E +DP N W+ V +M + R G C + GL+YV+GG + L S E Y+P++ +W+
Sbjct: 508 EVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGG-DDGSCNLASVEYYNPVTDKWTL 566
Query: 468 LPP-MGTRRAYLGVAALN 484
LP M T R+Y GVA ++
Sbjct: 567 LPTNMSTGRSYAGVAVIH 584
Score = 91.7 bits (226), Expect = 2e-18
Identities = 49/157 (31%), Positives = 83/157 (52%), Gaps = 2/157 (1%)
Query: 406 TIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRW 465
++E +D +E++W+ + + R G M G +Y +GG N + +R+ +VYD + +W
Sbjct: 316 SVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGF-NGSLRVRTVDVYDGVKDQW 374
Query: 466 SPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAG 525
+ + M RR+ LG A LND +Y+VGG++ + L +VE YS++ +W VA M R+
Sbjct: 375 TSIASMQERRSTLGAAVLNDLLYAVGGFDGST-GLASVEAYSYKTNEWFFVAPMNTRRSS 433
Query: 526 MCVVAVNGLLYVSGGRSSSHDFLAPDTHRYEVFRLKW 562
+ V V G LY GG + +Y +W
Sbjct: 434 VGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEW 470
Score = 62.8 bits (151), Expect = 9e-10
Identities = 36/119 (30%), Positives = 63/119 (52%), Gaps = 3/119 (2%)
Query: 438 LIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
++ V+GG + + I RS E YD RW + + +RR GV + +Y+VGG+N +
Sbjct: 302 VMIVVGGQAPKAI--RSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSL 359
Query: 498 DALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYE 556
+ TV+ Y +++W +ASM+ R+ + +N LLY GG S + + + Y+
Sbjct: 360 -RVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYK 417
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 291 bits (745), Expect = 1e-78
Identities = 166/494 (33%), Positives = 263/494 (53%), Gaps = 18/494 (3%)
Query: 52 RLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELI 111
RLVL++ S YFAA+FT ++E+ ++ + + G+E L+ + YTG + + +N++ L+
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 112 IAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHS 171
A +LQL++VV CC+FL Q+ P NC+GI F++ C DL + + NY HF+EV
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 172 GEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLL 231
+EF+ L ++ K+L S++++I +E + A + W+ DL +RRK + ++L IR PLL
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 232 PPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLY 291
PQ L +E F + Q L+ E + P+ LQ+ + +PRK L+
Sbjct: 354 APQ-FLADMENNVLFRDDIECQKLIMEAMKYHLLPERR---PMLQSPRTKPRKSTVGTLF 409
Query: 292 AVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE 351
AVGG +G + +E++D + WT V++++ R GV VL +Y +GG
Sbjct: 410 AVGGMDSTKGA--------TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR 461
Query: 352 KDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFD 411
+ ECY+P TK W+ + M+ R GLGV V G +YA+GG G NT+ER+D
Sbjct: 462 DGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWD 521
Query: 412 PDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPM 471
P +W V M+ R G + G +Y +GG L+S E +DP + +W+ M
Sbjct: 522 PQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSC-LKSVECFDPHTNKWTLCAQM 580
Query: 472 GTRRAYLGVAALNDCIYSVGGW-----NETQDALHTVEKYSFEEEKWVEVASMKVPRAGM 526
RR +GV N +Y++GG N T VE+Y + + W VASM + R +
Sbjct: 581 SKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAV 640
Query: 527 CVVAVNGLLYVSGG 540
V + LY GG
Sbjct: 641 GVCLLGDKLYAVGG 654
Score = 124 bits (311), Expect = 2e-28
Identities = 67/193 (34%), Positives = 104/193 (53%), Gaps = 15/193 (7%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+YAVGG+ WS L+ VER+D ++ W V+++ RS +GV VL G +YA+G
Sbjct: 502 MYAVGGHDG-----WS---YLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVG 553
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGW------VGAEI 403
G S EC+DP T +WT A M+ R G+GV G +YA+GG + + +
Sbjct: 554 GRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRL 613
Query: 404 GNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSK 463
+ +ER+DP + W V +M++SR G C + +Y +GG + L + E YDP +
Sbjct: 614 SDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAY-LNTVEAYDPQTN 672
Query: 464 RWSPLPPMGTRRA 476
W+ + P+ RA
Sbjct: 673 EWTQVAPLCLGRA 685
Score = 106 bits (265), Expect = 5e-23
Identities = 59/156 (37%), Positives = 90/156 (57%), Gaps = 4/156 (2%)
Query: 390 GAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEG 449
G ++A+GG + +IE++D N W V NM R FG + +YV+GG +G
Sbjct: 406 GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG--RDG 463
Query: 450 IE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
++ L + E Y+P +K WS +PPM T R LGVA L +Y+VGG ++ L+TVE++
Sbjct: 464 LKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGG-HDGWSYLNTVERWDP 522
Query: 509 EEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
+ +W VA+M PR+ + V ++G LY GGR S
Sbjct: 523 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGS 558
Score = 73.9 bits (180), Expect = 4e-13
Identities = 44/123 (35%), Positives = 60/123 (48%), Gaps = 5/123 (4%)
Query: 263 CKSPKENKFCSFLQTSKVRPRKKARKY---LYAVGGYTRLQGGRWSDSRALSCVERFDTF 319
C P NK+ Q SK R + LYA+GG+ SR CVER+D
Sbjct: 566 CFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL--TSRLSDCVERYDPK 623
Query: 320 SQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHP 379
+ WT V+S+ +R +GV +LG +YA+GG + E YDP T +WT VA +
Sbjct: 624 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 683
Query: 380 RCG 382
R G
Sbjct: 684 RAG 686
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 282 bits (721), Expect = 7e-76
Identities = 179/534 (33%), Positives = 266/534 (49%), Gaps = 21/534 (3%)
Query: 19 HAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVV 78
H++ +L +N +R CD+ L+VG AH++VLA+ SPYF A+FTG + E V
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEV 76
Query: 79 PILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLN 138
I+ Q ++++ YTG V I + V+ L+ AA++LQ+ V+ CC FL+ Q+DP N
Sbjct: 77 EFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGN 136
Query: 139 CIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEY 198
CIGI +F+E C DL + YI +F V EEF LT L +I+ ++ L++ E
Sbjct: 137 CIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEE 196
Query: 199 QVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKE 258
VF A WI D+ +R+K++ ++L+ +R PLL + L + E + LL E
Sbjct: 197 TVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNE 256
Query: 259 YCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDT 318
+ P+ S RPR A K L AVGG + L L VE +
Sbjct: 257 ALKYHFMPEHR--LSHQTVLMTRPR-CAPKVLCAVGGKSGL-------FACLDSVEMYFP 306
Query: 319 FSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT--------ECYDPVTKQW 370
+ W ++ L+ R G+ VL VY IGG ++ T EC++P T W
Sbjct: 307 QNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTW 366
Query: 371 TTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYF 430
T++ MN R LGV V G +YALGG+ G ++E++ P KW+ V M +R F
Sbjct: 367 TSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCF 426
Query: 431 GCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSV 490
+ G+IY IGG + S E YDP W + M +R + GV + I+ V
Sbjct: 427 AAAVLDGMIYAIGGYG--PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVV 484
Query: 491 GGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
GG N L ++E+Y + +W MK PR G+ ++ LYV GG S S
Sbjct: 485 GGHNGVSH-LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGS 537
Score = 90.1 bits (222), Expect = 5e-18
Identities = 58/195 (29%), Positives = 92/195 (47%), Gaps = 16/195 (8%)
Query: 376 MNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEM 435
M PRC V G L + +++E + P + W + + + RY FG C +
Sbjct: 275 MTRPRCAPKVLCAVGGKSGLFACL-----DSVEMYFPQNDSWIGLAPLNIPRYEFGICVL 329
Query: 436 QGLIYVIGGISNE---GIELR----SFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIY 488
+YVIGGI+ G+ +R S E ++P + W+ L M R+ LGV L +Y
Sbjct: 330 DQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELY 389
Query: 489 SVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFL 548
++GG+ + Q L +VEKY + KW VA M R+ ++G++Y GG +H
Sbjct: 390 ALGGY-DGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAH--- 445
Query: 549 APDTHRYEVFRLKWE 563
RY+ + WE
Sbjct: 446 MNSVERYDPSKDSWE 460
Score = 84.7 bits (208), Expect = 2e-16
Identities = 45/142 (31%), Positives = 65/142 (45%), Gaps = 9/142 (6%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+YA+GGY ++ VER+D W V+S+ R GV V+ G ++ +G
Sbjct: 435 IYAIGGYGPAH---------MNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVG 485
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
G E YDP QWT M PR G+G V +Y +GG G+ NT+++
Sbjct: 486 GHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQK 545
Query: 410 FDPDENKWEVVGNMAVSRYYFG 431
+DP + W M R FG
Sbjct: 546 YDPISDTWLDSAGMIYCRCNFG 567
Score = 60.8 bits (146), Expect = 3e-09
Identities = 27/97 (27%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
+++ VGG+ + LS +ER+D WT + + R+G+G V+ +Y +
Sbjct: 480 FIFVVGGHNGVSH--------LSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVV 531
Query: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGV 385
GG S + + YDP++ W A M + RC G+
Sbjct: 532 GGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
Score = 32.0 bits (71), Expect = 1.6
Identities = 22/75 (29%), Positives = 32/75 (42%), Gaps = 17/75 (22%)
Query: 276 QTSKVRPRKKAR---------KYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTV 326
Q + RP K+ R YLY VGG+ S S L+ V+++D S W
Sbjct: 505 QWTVCRPMKEPRTGVGAAVIDNYLYVVGGH--------SGSSYLNTVQKYDPISDTWLDS 556
Query: 327 SSLHQARSGLGVTVL 341
+ + R G+T L
Sbjct: 557 AGMIYCRCNFGLTAL 571
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 275 bits (704), Expect = 6e-74
Identities = 166/514 (32%), Positives = 262/514 (50%), Gaps = 12/514 (2%)
Query: 32 NGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQIL 91
NG+ CDV L+VG + H+LVLA PYF A+F M E+ + ++ I + + L
Sbjct: 63 NGE-LCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDL 121
Query: 92 LDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIAC 151
+ F+Y+ + + V+NVQ L+ AA +LQ+ V CCE++K P NC+ + F+E
Sbjct: 122 VKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNR 181
Query: 152 HDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKD 211
DL++ ++ Y HF EV E+F++++ L K+L S +L+IE+E QV+ AA++W+L +
Sbjct: 182 IDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLAN 241
Query: 212 LGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCKSPKENKF 271
K + E L +R PLLP L+ + + + LL E
Sbjct: 242 PQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAV 301
Query: 272 CSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQ 331
F + + PRK L+ VGG +GG R++ C + W ++
Sbjct: 302 PDFEYSIRTTPRKHTAGVLFCVGG----RGGSGDPFRSIEC---YSINKNSWFFGPEMNS 354
Query: 332 ARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGA 391
R +GV + G VYA+GG + E +DP+T +W ASMN R G+ + G
Sbjct: 355 RRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGP 414
Query: 392 IYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGI- 450
IYA+GG N +ER+D + ++W V M R G + +Y +GG N+G+
Sbjct: 415 IYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG--NDGMA 472
Query: 451 ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEE 510
L S E YDP +W + MG RRA GV+ L+ C+Y VGG+++ L +VE+Y
Sbjct: 473 SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDD-NSPLSSVERYDPRS 531
Query: 511 EKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSS 544
KW VA++ PR G+ + V G ++ GG + +
Sbjct: 532 NKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN 565
Score = 113 bits (283), Expect = 4e-25
Identities = 70/215 (32%), Positives = 101/215 (46%), Gaps = 13/215 (6%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+YA+GG D+ + VER+D S W+TV+ ++ R G+G L VYA+G
Sbjct: 415 IYAIGGL--------DDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVG 466
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
G E YDP +W V M R G GV +G +Y +GG+ +++ER
Sbjct: 467 GNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVER 526
Query: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLP 469
+DP NKW+ V + R G + G I+ +GG N L + E +DP+ RW +
Sbjct: 527 YDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGG-HNGNAYLNTVEAFDPVLNRWELVG 585
Query: 470 PMGTRRAYLGVA---ALNDCIYSVG-GWNETQDAL 500
+ RA GVA L I VG G N D +
Sbjct: 586 SVSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVDCM 620
Score = 100 bits (250), Expect = 3e-21
Identities = 59/166 (35%), Positives = 88/166 (53%), Gaps = 11/166 (6%)
Query: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
++YAVGG + +LS VER+D W V + Q R+G GV+ L G +Y +
Sbjct: 461 HVYAVGGNDGMA--------SLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVV 512
Query: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIE 408
GG D+ E YDP + +W VA++ PR G+G+ G I+A+GG G NT+E
Sbjct: 513 GGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVE 572
Query: 409 RFDPDENKWEVVGNMAVSRYYFG---CCEMQGLIYVIGGISNEGIE 451
FDP N+WE+VG+++ R G C + I +G SN ++
Sbjct: 573 AFDPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVD 618
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 260 bits (665), Expect = 2e-69
Identities = 159/494 (32%), Positives = 255/494 (51%), Gaps = 16/494 (3%)
Query: 70 MKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEF 129
M ES V I ++ ++L+D++YT + + NVQ L+ AA +LQL +V CCEF
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 130 LKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRS 189
L+ Q+ P+NC+GI F++ AC DLL + Y HF +V EEFL L +Q+ ++ S
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 190 EELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLR 249
++L+I E +VF A + W+ D R++ + +++ +R PLLP + L++ +E +
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 250 VALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRA 309
A + L E + P E + +++R K + VGG +A
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA---------PKA 231
Query: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQ 369
+ VE +D + W V+ L R G+ + G+V+A+GG S+ + YDPV Q
Sbjct: 232 IRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQ 291
Query: 370 WTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYY 429
WT+VA+M R LG V G +YA+GG+ G+ +++E ++ N+W V M R
Sbjct: 292 WTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSS 351
Query: 430 FGCCEMQGLIYVIGGISNEGIE-LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIY 488
G + GL+Y +GG + L + E Y+ + W+ + M TRR+ GV LN+ +Y
Sbjct: 352 VGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLY 411
Query: 489 SVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG-----RSS 543
+VGG ++ +VE Y W +VA M + R V AVNGLLYV GG +
Sbjct: 412 AVGG-HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLA 470
Query: 544 SHDFLAPDTHRYEV 557
S ++ P T ++ V
Sbjct: 471 SVEYYNPTTDKWTV 484
Score = 95.9 bits (237), Expect = 9e-20
Identities = 53/143 (37%), Positives = 76/143 (53%), Gaps = 7/143 (4%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
LYAVGGY + + LS VE ++ + WT ++ + RSG GV VL ++YA+G
Sbjct: 361 LYAVGGYDG------ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVG 414
Query: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIER 409
G ++ E YDP T W VA MN R GVC G +Y +GG G+ ++E
Sbjct: 415 GHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEY 474
Query: 410 FDPDENKWEVVGN-MAVSRYYFG 431
++P +KW VV + M+ R Y G
Sbjct: 475 YNPTTDKWTVVSSCMSTGRSYAG 497
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 253 bits (646), Expect = 3e-67
Identities = 166/535 (31%), Positives = 270/535 (50%), Gaps = 22/535 (4%)
Query: 13 PFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKE 72
P K + + N++R CDV ++V F AH+ +L + S YF ALFT G
Sbjct: 15 PHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNN 74
Query: 73 SSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
+ K V I GI + ++++++ YT V I +NV++L+ AAD + +V CCEFLK
Sbjct: 75 TEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKS 134
Query: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLE-VHSGEEFLALTKDQLIKILRSEE 191
++ NCIGI +F++ C +L + + +I +F E V EFL L+ +L I+ +E
Sbjct: 135 ELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDE 194
Query: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIE-----GVSDF 246
L+++ E VF A ++WI D R++H+ +L +R L+ + + ++ S+
Sbjct: 195 LNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEE 254
Query: 247 NLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSD 306
V + L Y P + F + L RPR L+A+GG WS
Sbjct: 255 CKPVIINALKAMYDLNMNGPSNSDFTNPL----TRPR-LPYAILFAIGG--------WSG 301
Query: 307 SRALSCVERFDTFSQYWTTVSSLHQA-RSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDP 365
+ +E +D + W V+ ++ R+ G L G VY IGG F+ + +DP
Sbjct: 302 GSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDP 361
Query: 366 VTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAV 425
V K W VA M+ RC + V V IYA+GG+ G NT ER++P+ N+W ++ M
Sbjct: 362 VKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHE 421
Query: 426 SRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALND 485
R + G +Y+ GG + L + EVY+ S +W+ + PM +RR+ +GV A +
Sbjct: 422 QRSDASATTLYGKVYICGGFNGNEC-LFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGE 480
Query: 486 CIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
+Y+VGG+ + + L + E YS W + +M PR+ + V+ LL+V GG
Sbjct: 481 HVYAVGGF-DGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGG 534
Score = 95.5 bits (236), Expect = 1e-19
Identities = 50/169 (29%), Positives = 84/169 (49%), Gaps = 3/169 (1%)
Query: 389 YGAIYALGGWVGAEIGNTIERFDPDENKW-EVVGNMAVSRYYFGCCEMQGLIYVIGGISN 447
Y ++A+GGW G N IE +D ++W V R Y G ++G +Y+IGG +
Sbjct: 290 YAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDS 349
Query: 448 EGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYS 507
S + +DP+ K W + PM +RR Y+ V L + IY++GG+ + L+T E+Y
Sbjct: 350 VDY-FNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGF-DGYVRLNTAERYE 407
Query: 508 FEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYE 556
E +W +A M R+ + G +Y+ GG + + + + E
Sbjct: 408 PETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTE 456
Score = 93.2 bits (230), Expect = 6e-19
Identities = 58/191 (30%), Positives = 89/191 (46%), Gaps = 11/191 (5%)
Query: 289 YLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAI 348
++YA+GG+ L+ ER++ + WT ++ +H+ RS T L G VY
Sbjct: 387 FIYAMGGFDGYV--------RLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC 438
Query: 349 GGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGA-IYALGGWVGAEIGNTI 407
GG + E Y+ + QWT +A M R G+GV + YG +YA+GG+ GA +
Sbjct: 439 GGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGV-IAYGEHVYAVGGFDGANRLRSA 497
Query: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSP 467
E + P N W + M R FG + L++V+GG N + E YD + W
Sbjct: 498 EAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGF-NGFTTTFNVECYDEKTDEWYD 556
Query: 468 LPPMGTRRAYL 478
M R+ L
Sbjct: 557 AHDMSIYRSAL 567
Score = 84.0 bits (206), Expect = 4e-16
Identities = 42/140 (30%), Positives = 69/140 (49%)
Query: 302 GRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTE 361
G ++ + L E ++T S WT ++ + RSG+GV G VYA+GG + E
Sbjct: 439 GGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAE 498
Query: 362 CYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVG 421
Y PV W T+ +M +PR G+ V ++ +GG+ G +E +D ++W
Sbjct: 499 AYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAH 558
Query: 422 NMAVSRYYFGCCEMQGLIYV 441
+M++ R CC + GL V
Sbjct: 559 DMSIYRSALSCCVVPGLANV 578
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 240 bits (612), Expect = 3e-63
Identities = 167/556 (30%), Positives = 263/556 (47%), Gaps = 55/556 (9%)
Query: 8 KAADSPFSSDKHAQLI---LAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAA 64
K + ++ + A+L+ + +N MR + CDV L V + AHR+VLAA+S +F
Sbjct: 12 KKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNL 71
Query: 65 LFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVH 124
+FT M ES V + E I + L++F YT +++ NNVQ L+ AA+ Q+ V
Sbjct: 72 MFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKK 131
Query: 125 LCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLI 184
+C +FLK Q+D NC+GI +E + C +L ++++IH HF EV+ +EFL L ++
Sbjct: 132 MCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVT 191
Query: 185 KILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVS 244
+L + L++ E QV+ AA++W+ D R+ +V++L +RFPL+ L K ++
Sbjct: 192 HLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQA-- 249
Query: 245 DFNLRVALQTLLKEYCEVCK-----------SPKENKFCSFLQTSKVRPRKKARKYLYAV 293
+ L+++ E K SP++ + RPR+K Y A+
Sbjct: 250 --------EPLIQDNPECLKMVISGMRYHLLSPEDREEL----VDGTRPRRKKHDYRIAL 297
Query: 294 GGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKD 353
G ++ Q R+ + + S WT + + R +VY +GG
Sbjct: 298 FGGSQPQSCRYFNPKDYS-----------WTDIRCPFEKRRDAACVFWDNVVYILGG--- 343
Query: 354 SMIFDC--TECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNT----I 407
S +F +CY+ V W + PR L C G IY G G+E+GN+
Sbjct: 344 SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG---GSEVGNSALYLF 400
Query: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIE---LRSFEVYDPLSKR 464
E +D W +M R G E GLIYV GG + L S EVYDP ++
Sbjct: 401 ECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATET 460
Query: 465 WSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRA 524
W+ L PM R G+ + D I++VGG N L VE Y + +W V+ M
Sbjct: 461 WTELCPMIEARKNHGLVFVKDKIFAVGGQNGL-GGLDNVEYYDIKLNEWKMVSPMPWKGV 519
Query: 525 GMCVVAVNGLLYVSGG 540
+ AV ++YV G
Sbjct: 520 TVKCAAVGSIVYVLAG 535
Score = 71.2 bits (173), Expect = 2e-12
Identities = 47/178 (26%), Positives = 76/178 (42%), Gaps = 5/178 (2%)
Query: 292 AVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE 351
A G GG + AL E +DT ++ W T S+ R G+ G++Y GG
Sbjct: 379 AAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGS 438
Query: 352 KDS----MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTI 407
+ + + E YDP T+ WT + M R G+ I+A+GG G + +
Sbjct: 439 LGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNV 498
Query: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRW 465
E +D N+W++V M C + ++YV+ G G L Y+ + +W
Sbjct: 499 EYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVG-RLGHILEYNTETDKW 555
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 233 bits (595), Expect = 3e-61
Identities = 161/524 (30%), Positives = 248/524 (47%), Gaps = 52/524 (9%)
Query: 37 CDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESSKDVVPILGIEAGIFQILLDFIY 96
CDV L V + AHR+VLAA+S +F +FT M ES V + E I + L++F Y
Sbjct: 22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAY 81
Query: 97 TGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLE 156
T +++ NNVQ L+ AA+ Q+ V +C +FLK Q+D NC+GI +E + C +L
Sbjct: 82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKA 141
Query: 157 FSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSIEDEYQVFLAAMQWILKDLGKRR 216
++++IH HF EV+ +EFL L ++ +L + L++ E QV+ AA++W+ D R+
Sbjct: 142 TADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 201
Query: 217 KHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQTLLKEYCEVCK-----------S 265
+V++L +RFPL+ L K ++ + L+++ E K S
Sbjct: 202 PFMVDILAKVRFPLISKNFLSKTVQA----------EPLIQDNPECLKMVISGMRYHLLS 251
Query: 266 PKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTT 325
P++ + RPR+K Y A+ G ++ Q R+ + + S WT
Sbjct: 252 PEDREEL----VDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYS-----------WTD 296
Query: 326 VSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDC--TECYDPVTKQWTTVASMNHPRCGL 383
+ + R +VY +GG S +F +CY+ V W + PR L
Sbjct: 297 IRCPFEKRRDAACVFWDNVVYILGG---SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSL 353
Query: 384 GVCVCYGAIYALGGWVGAEIGNT----IERFDPDENKWEVVGNMAVSRYYFGCCEMQGLI 439
C G IY G G+E+GN+ E +D W +M R G E GLI
Sbjct: 354 AACAAEGKIYTSG---GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLI 410
Query: 440 YVIGGISNEGIE---LRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNET 496
YV GG + L S EVYDP ++ W+ L PM R G+ + D I++VGG N
Sbjct: 411 YVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGL 470
Query: 497 QDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGG 540
L VE Y + +W V+ M + AV ++YV G
Sbjct: 471 -GGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAG 513
Score = 71.2 bits (173), Expect = 2e-12
Identities = 47/178 (26%), Positives = 76/178 (42%), Gaps = 5/178 (2%)
Query: 292 AVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE 351
A G GG + AL E +DT ++ W T S+ R G+ G++Y GG
Sbjct: 357 AAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGS 416
Query: 352 KDS----MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTI 407
+ + + E YDP T+ WT + M R G+ I+A+GG G + +
Sbjct: 417 LGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNV 476
Query: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRW 465
E +D N+W++V M C + ++YV+ G G L Y+ + +W
Sbjct: 477 EYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVG-RLGHILEYNTETDKW 533
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 216 bits (549), Expect = 6e-56
Identities = 153/574 (26%), Positives = 271/574 (47%), Gaps = 25/574 (4%)
Query: 4 EDCPKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQ--ESFKAHRLVLAASSPY 61
+ C F+S+ H+ ++L +++R CDV L G E F HR ++A++S Y
Sbjct: 17 QPCKAGTTRFFTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEIFPVHRAMMASASDY 76
Query: 62 FAALFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTE 121
F A+FTGGMKE + + G+ + ++DFIYT +++ ++N+Q+ + AA LQ+
Sbjct: 77 FKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAASFLQILP 136
Query: 122 VVHLCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKD 181
V+ C FL + NC+ + + + ++ ++ N+I +F + S EFL L +
Sbjct: 137 VLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGEFLKLPFE 196
Query: 182 QLIKILRSEELSIEDEYQVFLAAMQWI-LKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYI 240
+L +L S L E ++F AA +W+ L+D R + +++ IRFPL+ PQ L+ Y+
Sbjct: 197 RLAFVLSSNSLKHCTELELFKAACRWLRLED--PRMDYAAKLMKNIRFPLMTPQDLINYV 254
Query: 241 EGVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQ 300
+ V LL E P +Q+ + R + +L +GG R Q
Sbjct: 255 QTVDFMRTDNTCVNLLLEASNYQMMPYMQ---PVMQSDRTAIRSDS-THLVTLGGVLRQQ 310
Query: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-----KDSM 355
+ R +D +Q W +++ + R G+ V+G +Y +GG+ K
Sbjct: 311 LVVSKELR------MYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKT 364
Query: 356 IFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDEN 415
D +DP +W VAS+N R + G +YA+GG A T+E ++P N
Sbjct: 365 AVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMN 424
Query: 416 KWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRR 475
+W V M+ Y GL+Y+ GGI+++ + +DP + +W PM T R
Sbjct: 425 EWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQ-NELMCFDPDTDKWMQKAPMTTVR 483
Query: 476 AYLGVAALNDCIYSVGG----WNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAV 531
+ + D +Y +GG D + + E YS ++W +A+M ++ + V
Sbjct: 484 GLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVF 543
Query: 532 NGLLYVSGGRSSSHDFLAPDTHRYEVFRLKWENM 565
+YV GG S ++ + +Y+ + +W +
Sbjct: 544 ENKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKV 577
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/215 (23%), Positives = 86/215 (40%), Gaps = 59/215 (27%)
Query: 266 PKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTT 325
P+ NK+ ++ K+ +L A+ G+ GGR S + L+ VE ++ W+
Sbjct: 374 PRYNKWMQVASLNE----KRTFFHLSALKGHLYAVGGR-SAAGELATVECYNPRMNEWSY 428
Query: 326 VSSLHQARSGLGVTVLGGMVYAIGG------EKDSMIFD--------------------- 358
V+ + + G TV GG++Y GG + + M FD
Sbjct: 429 VAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCM 488
Query: 359 CT-------------------------ECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIY 393
CT E Y P QWT +A+M + +GV V IY
Sbjct: 489 CTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIY 548
Query: 394 ALGG--WVGAEIGNTIERFDPDENKWEVVGNMAVS 426
+GG W + ++++DP++++W V ++ S
Sbjct: 549 VVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPES 583
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 214 bits (545), Expect = 2e-55
Identities = 153/550 (27%), Positives = 252/550 (45%), Gaps = 54/550 (9%)
Query: 15 SSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKESS 74
S HA+ IL N+ R+ + F DV + V + F HR VL+A S YF A+F +ES
Sbjct: 44 SGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESR 103
Query: 75 KDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKGQI 134
+ +V I GI A + L ++YTG V I NVQ L + + Q++ + C +FL+ Q+
Sbjct: 104 EMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQL 163
Query: 135 DPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEELSI 194
DP NC+GI +F++ + L +N+ F +V EEFL L KD+LI + S+EL I
Sbjct: 164 DPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVI 223
Query: 195 EDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVALQT 254
E VF A M+W+ + + RR + E+L +R PLL P ++ +E + +Q
Sbjct: 224 GKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE------VDQLIQN 277
Query: 255 LLKEYCEVCKSPKENKFCSFLQTSKVRPRKKA--RKYLYAVGGYTRLQG----------- 301
+ Y + ++ + + + + + + RPR+ + + VGG R+ G
Sbjct: 278 SPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDP 337
Query: 302 --GRW---------SDSRALSCVER-----------------FDTFSQYWTTVSSLHQAR 333
G W + S C R +++ W V+SL++ R
Sbjct: 338 VTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGR 397
Query: 334 SGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIY 393
+ VL G VY +GG ECYD + +WT VA + V C G ++
Sbjct: 398 WRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLF 457
Query: 394 ALGGWVGAE-IGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIEL 452
+GG + ++ +DP+ N W + + +++ + LIYV GG++
Sbjct: 458 VIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLT------ 511
Query: 453 RSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEK 512
++ YDP+ W + +R+ G++ N IY +GG E +A T+ Y
Sbjct: 512 KAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSI 571
Query: 513 WVEVASMKVP 522
VA+M P
Sbjct: 572 ITGVAAMPRP 581
Score = 73.2 bits (178), Expect = 6e-13
Identities = 57/196 (29%), Positives = 82/196 (41%), Gaps = 14/196 (7%)
Query: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
+Y VGGY LS VE +D+FS WT V+ L +A S VT G ++ IG
Sbjct: 409 VYVVGGY--------DGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIG 460
Query: 350 G-EKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIE 408
G D+ D + YDP T W A++ + + IY GG A I
Sbjct: 461 GGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKA-----IY 515
Query: 409 RFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPL 468
+DP E+ W V N + G G IY++GG G + YDP + + +
Sbjct: 516 CYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGV 575
Query: 469 PPMGTRRAYLGVAALN 484
M +Y G ++
Sbjct: 576 AAMPRPVSYHGCVTIH 591
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 213 bits (543), Expect = 3e-55
Identities = 160/541 (29%), Positives = 242/541 (44%), Gaps = 32/541 (5%)
Query: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73
F H +LA +N +R F DV L G +F HR VLAASS YF A+F+ G++ES
Sbjct: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
Query: 74 SKDVVPIL-GIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
D V + + ++LLDF Y+ + I N + L+ A DMLQ +V EFL+
Sbjct: 83 RDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Query: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEEL 192
+ P NC+G+ S+ C L EFS VHF V E+F +L+KD L+ ++ S+EL
Sbjct: 143 NLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDEL 202
Query: 193 SIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVAL 252
EDE VF A +QW+ DL R+ H+ E+L +R LLP L E VS L +A
Sbjct: 203 ETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQ---EAVSSEALLMAD 259
Query: 253 Q--TLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQGGRWS-DSRA 309
+ L+ + CK+ + + + + RPR KA L +GG T + + D +A
Sbjct: 260 ERTKLIMDEALRCKT-RILQNDGVVTSPCARPR-KAGHTLLILGGQTFMCDKIYQVDHKA 317
Query: 310 LSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-KDSMIFDCTECYDPVTK 368
+ + D L R + +G VY GG ++ + YD V +
Sbjct: 318 KEIIPKAD-----------LPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHE 366
Query: 369 QWTTVASMNHPRCGLGVCVCYGAIYALGGWVG---------AEIGNTIERFDPDENKWEV 419
+W+ A M R G G +Y +GG + +E++DP NKW +
Sbjct: 367 EWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMM 426
Query: 420 VGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLG 479
V + + ++V GG S + + YDP RW+ Y
Sbjct: 427 VAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTA 486
Query: 480 VAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSG 539
A L I+ +GG +T+ + ++ E +W + M R +A LYV G
Sbjct: 487 AAVLGSQIFIMGG--DTEFTAASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVG 544
Query: 540 G 540
G
Sbjct: 545 G 545
Score = 57.4 bits (137), Expect = 4e-08
Identities = 38/119 (31%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 439 IYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQD 498
+YV GG +E + VYD + + WS PM R G A L +C+Y VGG
Sbjct: 342 VYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAG 401
Query: 499 --------ALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLA 549
+L VEKY KW+ VA ++ + VV+ L+V GG S D ++
Sbjct: 402 VFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVS 460
Score = 52.0 bits (123), Expect = 2e-06
Identities = 31/128 (24%), Positives = 51/128 (39%), Gaps = 5/128 (3%)
Query: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
GG +S V+ +D WT + Q VLG ++ +GG+ + F
Sbjct: 450 GGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTE---FTAA 506
Query: 361 ECY--DPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWE 418
Y D T QWT + M R +Y +GG+ G + T++ +DP + W
Sbjct: 507 SAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Query: 419 VVGNMAVS 426
+ + S
Sbjct: 567 CITTVPYS 574
Score = 33.9 bits (76), Expect = 0.42
Identities = 22/85 (25%), Positives = 33/85 (38%)
Query: 459 DPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVAS 518
D +K P + + R +A+ +Y GG V Y E+W + A
Sbjct: 314 DHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAP 373
Query: 519 MKVPRAGMCVVAVNGLLYVSGGRSS 543
M + R G + LYV GG +S
Sbjct: 374 MLIARFGHGSAELENCLYVVGGHTS 398
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 212 bits (540), Expect = 7e-55
Identities = 156/573 (27%), Positives = 265/573 (46%), Gaps = 60/573 (10%)
Query: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQ--ESFKAHRLVLAASSPYFAALFTGGMK 71
F+S+ H+ ++L +++R CDV L G ++F HR+++A++S YF A+FTGGMK
Sbjct: 69 FTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDAFPVHRVMMASASDYFKAMFTGGMK 128
Query: 72 ESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLK 131
E + + G+ + ++DFIYT +++ ++N+Q+ + AA LQ+ V+ C FL
Sbjct: 129 EQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVFLI 188
Query: 132 GQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEE 191
+ NC+ + + + ++ ++ +++ +F + S EFL L ++L +L S
Sbjct: 189 SGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLPFERLAFVLSSNS 248
Query: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGV-------- 243
L E ++F A +W+ + R +++ IRFPL+ PQ L+ Y++ V
Sbjct: 249 LKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINYVQTVDFMRTDNT 307
Query: 244 -----------------------------SDFNLRVALQTLLKEYCEVCK-----SPKEN 269
SD V L +L++ V K K +
Sbjct: 308 CVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAH 367
Query: 270 KFCSFLQTSKVRPRKKAR---KYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTV 326
++ S R + +LY VGG + A+ V RFD W V
Sbjct: 368 EWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYD---TKGKTAVDTVFRFDPRYNKWMQV 424
Query: 327 SSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVC 386
+SL++ R+ ++ L G +YA+GG + ECY+P T +WT VA M+ P G
Sbjct: 425 ASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGT 484
Query: 387 VCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGIS 446
V G +Y GG + FDPD +KW M R C + +YVIGG
Sbjct: 485 VYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNH 544
Query: 447 NEGI----ELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGG--WNETQDAL 500
G ++ S E Y P+ +W+P+ M ++ +GVA + IY VGG WN + +
Sbjct: 545 FRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWN-NRCMV 603
Query: 501 HTVEKYSFEEEKWVEVASMKVPRAGM--CVVAV 531
V+KY ++++W +V + G+ C + V
Sbjct: 604 EIVQKYDPDKDEWHKVFDLPESLGGIRACTLTV 636
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 212 bits (540), Expect = 7e-55
Identities = 155/570 (27%), Positives = 261/570 (45%), Gaps = 28/570 (4%)
Query: 7 PKAADSPFSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALF 66
P ++ + S +H+Q +L + +R+ DV L V +AHR++LAAS YF +F
Sbjct: 20 PHCVNNTYRSAQHSQALLRGLLALRDSGILFDVVLVVEGRHIEAHRILLAASCDYFRGMF 79
Query: 67 TGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLC 126
GG+KE ++ V I G+ +L FIYT + + ++NVQE ++AA LQ+ E++H C
Sbjct: 80 AGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFC 139
Query: 127 CEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKI 186
C+FL +D N + +++ +E L E + YI +F+ +++ L +++ +
Sbjct: 140 CDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQLPLEKVYSL 199
Query: 187 LRSEELSIEDEYQVFLAAM--QWILKDLGKRRKHVVE---VLDPIRFPLLPPQRLLKYIE 241
L S L + E +V+ A+ + L+ + + + E +L+ +RFPL+ + L + +
Sbjct: 200 LSSNRLEVSCETEVYEGALLYHYSLEQVQADQISLHEPPKLLETVRFPLMEAEVLQRLHD 259
Query: 242 GVSDFNLRVALQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTRLQG 301
+ LR + + L + LQ S P+ + R V G+ +
Sbjct: 260 KLDPSPLRDTVASALMYHRN-----------ESLQPSLQSPQTELRSDFQCVVGFGGIHS 308
Query: 302 GRWSDSRALSCVERF--DTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDC 359
+ S LS ++ ++ +SL S G+ VL VY IGG+ + F
Sbjct: 309 ---TPSTVLSDQAKYLNPLLGEWKHFTASLAPRMSNQGIAVLNNFVYLIGGDNNVQGFRA 365
Query: 360 -TEC--YDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENK 416
+ C YDP +W + S+ L VCV IYA+ G N +ER+DP N
Sbjct: 366 ESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHNDLNAVERYDPATNS 425
Query: 417 WEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRA 476
W V + Y ++G +Y+ G E L+ YDP S W L RRA
Sbjct: 426 WAYVAPLKREVYAHAGATLEGKMYITCGRRGEDY-LKETHCYDPGSNTWHTLADGPVRRA 484
Query: 477 YLGVAALNDCIYSVGGWNET---QDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
+ G+A L + +Y +GG N + +H V YS +W V + + ++
Sbjct: 485 WHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEPGIAVLDN 544
Query: 534 LLYVSGGRSSSHDFLAPDTHRYEVFRLKWE 563
+YV GGRS + H Y+V + WE
Sbjct: 545 RIYVLGGRSHNRGSRTGYVHIYDVEKDCWE 574
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 207 bits (527), Expect = 2e-53
Identities = 151/554 (27%), Positives = 241/554 (43%), Gaps = 59/554 (10%)
Query: 13 PFSSDKHAQLILAQINKMRNGQHFCDVQLQV-GQESFKAHRLVLAASSPYFAALFTGGMK 71
PFS HA +L ++++R + F DV L+ G F AHR VLAA+SPYF A+F G ++
Sbjct: 11 PFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQLR 70
Query: 72 ESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLK 131
ES + V + G+ + Q+LLDF YTG V + +N + L+ AAD+LQ V C FL+
Sbjct: 71 ESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACGAFLQ 130
Query: 132 GQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEE 191
Q+D NC+ + F+E +C L ++ +I H E+ E+ L +L++ LR +
Sbjct: 131 QQLDLANCLDMQDFAEAFSCSGLASAAQRFILRHVGEL-GAEQLERLPLARLLRYLRDDG 189
Query: 192 LSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVA 251
L + E + A++W+ D +R H ++L+ +R P + LL ++E
Sbjct: 190 LCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEPLVARCPP 249
Query: 252 LQTLLKEYCEVCKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYTR------------L 299
LL+E + + + + RP + L VGG +
Sbjct: 250 CLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELVTVDCYNP 309
Query: 300 QGGRW-----------------------------SDSRALSCVERFDTFSQYWTTVSSLH 330
Q G+W SR CV R+++ W V+ +
Sbjct: 310 QTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPML 369
Query: 331 QARSGLGVTVLGGMVYAIGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYG 390
+AR +VL G++Y + D TE YD T W + M +P C G
Sbjct: 370 KAREYHSSSVLDGLLYVVAA-------DSTERYDHTTDSWEALQPMTYPMDNCSTTACRG 422
Query: 391 AIYALGGWVGAEIGNTIERFDPDENKWEVV--GNMAVSRYYFGCCEMQGLIYVIGGISNE 448
+YA+G G E ++ +DPD + W +V G + + + GL+Y + S E
Sbjct: 423 RLYAIGSLAGKET-MVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAE 481
Query: 449 GIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSF 508
+VY+P W +P M +A L +Y GG++ T + VE Y
Sbjct: 482 ------VDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDP 535
Query: 509 EEEKWVEVASMKVP 522
E W V + P
Sbjct: 536 ETRAWSVVGRLPEP 549
Score = 53.1 bits (126), Expect = 7e-07
Identities = 35/167 (20%), Positives = 58/167 (34%), Gaps = 44/167 (26%)
Query: 309 ALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGG--EKDSMIFDC------- 359
A ER+D + W + + T G +YAIG K++M+ C
Sbjct: 388 AADSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDL 447
Query: 360 ----------------------------------TECYDPVTKQWTTVASMNHPRCGLGV 385
+ Y+P +W + SMN G +
Sbjct: 448 WSLVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSMNQVHVGGSL 507
Query: 386 CVCYGAIYALGGWVGA-EIGNTIERFDPDENKWEVVGNMAVSRYYFG 431
V G +Y GG+ E+ + +E +DP+ W VVG + ++ G
Sbjct: 508 AVLGGKLYVSGGYDNTFELSDVVEAYDPETRAWSVVGRLPEPTFWHG 554
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 204 bits (518), Expect = 2e-52
Identities = 154/547 (28%), Positives = 242/547 (44%), Gaps = 44/547 (8%)
Query: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAALFTGGMKES 73
F +A +L +N +R + F DV L G +F HR VLAA S YF A+F+GG+KES
Sbjct: 23 FHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKES 82
Query: 74 SKDVVPI-LGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFLKG 132
V I + ++LLD+ Y+ V I N + L+ A DML+ ++ C EFL+
Sbjct: 83 QDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEK 142
Query: 133 QIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILRSEEL 192
+ P NC+G+ S+ C L E S +F + E+FL L +D ++++L SEEL
Sbjct: 143 NLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEEL 202
Query: 193 SIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSDFNLRVAL 252
EDE V+ +A+ WI DL KR ++ E+L +R LLP L++ VA+
Sbjct: 203 ETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLME----------NVAM 252
Query: 253 QTLLKEYCEVCKSPKENKFC--SFLQTSKV------RPRKKARKYLYAVGGYTRLQGGRW 304
+ L+ + + + +E C LQ V RPRK L+ +GG T + +
Sbjct: 253 EELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHA-LFLLGGQTFMCDKLY 311
Query: 305 -SDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE-KDSMIFDCTEC 362
D +A + + D + R +G VY GG ++ +
Sbjct: 312 LVDQKAKEIIPKAD-----------IPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWV 360
Query: 363 YDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAE---------IGNTIERFDPD 413
YD + ++W+ A M R G G +Y +GG A +E +DP
Sbjct: 361 YDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPT 420
Query: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473
NKW +V + + ++ GG S +L + YD RW+
Sbjct: 421 INKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQ 480
Query: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
Y A L + I+ +GG +T+ + + K++ E +W +V + R VA
Sbjct: 481 PWRYTAAAVLGNQIFIMGG--DTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGN 538
Query: 534 LLYVSGG 540
LYV GG
Sbjct: 539 KLYVVGG 545
Score = 63.9 bits (154), Expect = 4e-10
Identities = 45/144 (31%), Positives = 60/144 (41%), Gaps = 9/144 (6%)
Query: 427 RYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDC 486
R F C + +Y+ GG +E + VYD L + WS PM R G A L C
Sbjct: 330 RKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHC 389
Query: 487 IYSVGGWNETQD--------ALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVS 538
+Y VGG +L VE Y KW VA ++ + VV+ L+
Sbjct: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAF 449
Query: 539 GGRSSSHDFLAPDTHRYEVFRLKW 562
GG S SHD L P Y+ +W
Sbjct: 450 GGTSVSHDKL-PKVQCYDQCENRW 472
Score = 47.0 bits (110), Expect = 5e-05
Identities = 30/128 (23%), Positives = 51/128 (39%), Gaps = 5/128 (3%)
Query: 301 GGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCT 360
GG L V+ +D WT ++ Q VLG ++ +GG+ + F
Sbjct: 450 GGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTE---FSAC 506
Query: 361 ECY--DPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWE 418
Y + T QWT V + R +Y +GG+ G + T++ +DP + W
Sbjct: 507 SAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWN 566
Query: 419 VVGNMAVS 426
+ + S
Sbjct: 567 SITTVPYS 574
Score = 32.0 bits (71), Expect = 1.6
Identities = 22/86 (25%), Positives = 33/86 (38%)
Query: 459 DPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVAS 518
D +K P + + R A+ +Y GG V Y E+W + A
Sbjct: 314 DQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAP 373
Query: 519 MKVPRAGMCVVAVNGLLYVSGGRSSS 544
M V R G + LYV GG +++
Sbjct: 374 MLVARFGHGSAELKHCLYVVGGHTAA 399
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,952,820
Number of Sequences: 37866
Number of extensions: 964099
Number of successful extensions: 3400
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 2003
Number of HSP's gapped (non-prelim): 438
length of query: 582
length of database: 18,247,518
effective HSP length: 108
effective length of query: 474
effective length of database: 14,157,990
effective search space: 6710887260
effective search space used: 6710887260
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.