Search of human proteins with 222537739

Search of human proteins with 222537739

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222537739 ER degradation enhancer, mannosidase alpha-like 2
isoform 2 [Homo sapiens]
         (541 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222537739 ER degradation enhancer, mannosidase alpha-like 2 i...  1105   0.0  
gi|222537737 ER degradation enhancer, mannosidase alpha-like 2 i...  1086   0.0  
gi|7662002 ER degradation enhancer, mannosidase alpha-like 1 [Ho...   328   6e-90
gi|163310725 ER degradation enhancer, mannosidase alpha-like 3 [...   288   9e-78
gi|9966903 mannosidase, alpha, class 1C, member 1 [Homo sapiens]      166   4e-41
gi|24497519 mannosidase, alpha, class 1A, member 1 [Homo sapiens]     166   7e-41
gi|5729913 mannosidase, alpha, class 1A, member 2 [Homo sapiens]      165   9e-41
gi|218749883 alpha 1,2-mannosidase [Homo sapiens]                     155   9e-38
gi|53988380 mesothelin isoform 2 preproprotein [Homo sapiens]          32   1.1  
gi|53988378 mesothelin isoform 1 preproprotein [Homo sapiens]          32   1.1  
gi|18921093 transient receptor potential cation channel, subfami...    31   2.5  
gi|82775371 coiled-coil domain containing 93 [Homo sapiens]            30   4.3  
gi|187171277 DNA-directed DNA polymerase gamma [Homo sapiens]          30   5.6  
gi|4505937 DNA-directed DNA polymerase gamma [Homo sapiens]            30   5.6  
gi|42476320 sushi domain containing 1 [Homo sapiens]                   30   7.3  

>gi|222537739 ER degradation enhancer, mannosidase alpha-like 2
           isoform 2 [Homo sapiens]
          Length = 541

 Score = 1105 bits (2857), Expect = 0.0
 Identities = 541/541 (100%), Positives = 541/541 (100%)

Query: 1   MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYSFSLTLIDALDTLLILGNVSEFQRV 60
           MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYSFSLTLIDALDTLLILGNVSEFQRV
Sbjct: 1   MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYSFSLTLIDALDTLLILGNVSEFQRV 60

Query: 61  VEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEA 120
           VEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEA
Sbjct: 61  VEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEA 120

Query: 121 ARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDV 180
           ARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDV
Sbjct: 121 ARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDV 180

Query: 181 ARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLM 240
           ARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLM
Sbjct: 181 ARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLM 240

Query: 241 AMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFL 300
           AMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFL
Sbjct: 241 AMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFL 300

Query: 301 NYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAV 360
           NYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAV
Sbjct: 301 NYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAV 360

Query: 361 ESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAV 420
           ESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAV
Sbjct: 361 ESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAV 420

Query: 421 ITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQK 480
           ITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQK
Sbjct: 421 ITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQK 480

Query: 481 NTVSSGPWEPPARPGTLFSPENHDQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDS 540
           NTVSSGPWEPPARPGTLFSPENHDQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDS
Sbjct: 481 NTVSSGPWEPPARPGTLFSPENHDQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDS 540

Query: 541 S 541
           S
Sbjct: 541 S 541


>gi|222537737 ER degradation enhancer, mannosidase alpha-like 2
           isoform 1 [Homo sapiens]
          Length = 578

 Score = 1086 bits (2809), Expect = 0.0
 Identities = 541/578 (93%), Positives = 541/578 (93%), Gaps = 37/578 (6%)

Query: 1   MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHY------------------------- 35
           MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHY                         
Sbjct: 1   MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDEL 60

Query: 36  ------------SFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNI 83
                       SFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNI
Sbjct: 61  RPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNI 120

Query: 84  RVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLH 143
           RVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLH
Sbjct: 121 RVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLH 180

Query: 144 GVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHID 203
           GVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHID
Sbjct: 181 GVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHID 240

Query: 204 VLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWV 263
           VLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWV
Sbjct: 241 VLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWV 300

Query: 264 QMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYT 323
           QMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYT
Sbjct: 301 QMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYT 360

Query: 324 VEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHK 383
           VEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHK
Sbjct: 361 VEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHK 420

Query: 384 LDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPI 443
           LDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPI
Sbjct: 421 LDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPI 480

Query: 444 DPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENH 503
           DPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENH
Sbjct: 481 DPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENH 540

Query: 504 DQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS 541
           DQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS
Sbjct: 541 DQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS 578


>gi|7662002 ER degradation enhancer, mannosidase alpha-like 1 [Homo
           sapiens]
          Length = 657

 Score =  328 bits (842), Expect = 6e-90
 Identities = 203/498 (40%), Positives = 288/498 (57%), Gaps = 56/498 (11%)

Query: 15  LLPQHHGAPGPDGSAPDPAHYS-----FSLTLIDALDTLLILGNVSEFQRVVEVLQDSVD 69
           L P H    GPD   P   + +     +SLTL+DALDTL I+GN SEFQ+ V+++ ++V 
Sbjct: 155 LNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVS 214

Query: 70  FDIDVNASVFETNIRVVGGLLSAHLL---SKKAGVEVEAGWPCSGPLLRMAEEAARKLLP 126
           FD D    VFE  IRV+G LLSAH +   SK+   ++         LL MA + A +LLP
Sbjct: 215 FDKDSTVQVFEATIRVLGSLLSAHRIITDSKQPFGDMTIK-DYDNELLYMAHDLAVRLLP 273

Query: 127 AFQ-TPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVAL 185
           AF+ T TG+PY  VNL  GV P     TCTAG G+ +VEF  LS L GD  FE VAR A+
Sbjct: 274 AFENTKTGIPYPRVNLKTGVPPDTNNETCTAGAGSLLVEFGILSRLLGDSTFEWVARRAV 333

Query: 186 MRLWESRS-DIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFL 244
             LW  RS D GL+GN +++ TG WV + +G+GAG+DS++EYL+K  IL  +K+ + MF 
Sbjct: 334 KALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFN 393

Query: 245 EYNKAIRNYTRFD-----------DWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDID 293
              ++I+NY R               Y+ V M+ G +      SL+A++PGLQ LIGD++
Sbjct: 394 AAYQSIQNYLRRGREACNEGEGDPPLYVNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVE 453

Query: 294 NAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREG--YPLRPELIESAMYLYRATGDPT 351
           +A+     YY +WK++G LPE YN    + ++  +   YPLRPEL+ES   LY+AT +P 
Sbjct: 454 DAICLHAFYYAIWKRYGALPERYN----WQLQAPDVLFYPLRPELVESTYLLYQATKNPF 509

Query: 352 LLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIH 411
            L +G D ++S+EK +KV+CG+AT+  + D   ++RMESFFL+ET KYLYLLFD  N +H
Sbjct: 510 YLHVGMDILQSLEKYTKVKCGYATLHHVIDKSTEDRMESFFLSETCKYLYLLFDEDNPVH 569

Query: 412 NNGSTFDAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSL 471
            +G+                  Y+F TE H +        + L+E  W      +EF+S 
Sbjct: 570 KSGTR-----------------YMFTTEGHIVS-----VDEHLRELPW------KEFFSE 601

Query: 472 KRSRSKFQKNTVSSGPWE 489
           +  + +  K+     P E
Sbjct: 602 EGGQDQGGKSVHRPKPHE 619


>gi|163310725 ER degradation enhancer, mannosidase alpha-like 3
           [Homo sapiens]
          Length = 932

 Score =  288 bits (737), Expect = 9e-78
 Identities = 179/424 (42%), Positives = 239/424 (56%), Gaps = 27/424 (6%)

Query: 25  PDGSAPDPAHYSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIR 84
           P     D A   FSLTLID+LDTL++L    EF+  V  +   V+ D DV  SVFETNIR
Sbjct: 91  PSRGDVDDALGKFSLTLIDSLDTLVVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIR 150

Query: 85  VVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHG 144
           V+GGLL  H L+     + E     +  LL+MA++   KLLPAF T +G+PY  +NL  G
Sbjct: 151 VLGGLLGGHSLAIMLKEKGEYMQWYNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFG 210

Query: 145 VNPGETPV-----TCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRS-DIGLV 198
           +   E        TCTA  GT I+EFA LS  TG  +FE+ AR AL  LWE R     LV
Sbjct: 211 IRKPEARTGTETDTCTACAGTLILEFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLV 270

Query: 199 GNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDD 258
           G  I++ TG WV +D+G+GAG+DSY+EYL+K  +LL D   +  F  +  AI  Y     
Sbjct: 271 GVTINIHTGDWVRKDSGVGAGIDSYYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPP 330

Query: 259 WYLWVQMYKGTVSMPVFQ-SLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYN 317
             L V ++K  ++   +  +L A++PGLQ L GDI  A+ T    Y V K+   LPE + 
Sbjct: 331 LLLDVHIHKPMLNARTWMDALLAFFPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFT 390

Query: 318 IPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIK 377
               + V   + +PLRPE  ES  +LY+ATGDP  LE+G+  +E++ K ++V CGFA +K
Sbjct: 391 TD--FRVHWAQ-HPLRPEFAESTYFLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMK 447

Query: 378 DLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFN 437
           D+R    ++RM+SFFLAE  KYLYLLF                     + I     YIF 
Sbjct: 448 DVRTGSHEDRMDSFFLAEMFKYLYLLFADKE-----------------DIIFDIEDYIFT 490

Query: 438 TEAH 441
           TEAH
Sbjct: 491 TEAH 494


>gi|9966903 mannosidase, alpha, class 1C, member 1 [Homo sapiens]
          Length = 630

 Score =  166 bits (421), Expect = 4e-41
 Identities = 132/437 (30%), Positives = 200/437 (45%), Gaps = 73/437 (16%)

Query: 40  TLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKA 99
           T+ID+LDTL ++    EFQ     + +S   ++   AS+FE NIR +GGLLSA  L+ + 
Sbjct: 219 TVIDSLDTLYLMELKEEFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEE 278

Query: 100 GVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHG----VNPGETPVTCT 155
              ++A        +R+ E    KLLPAF TPTG+P G V+   G       G + +   
Sbjct: 279 VFRIKA--------IRLGE----KLLPAFNTPTGIPKGVVSFKSGNWGWATAGSSSI--L 324

Query: 156 AGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAG 215
           A  G+  +EF  L+ L+G+ VF +  R     L +     GL  N +  ++G WV     
Sbjct: 325 AEFGSLHLEFLHLTELSGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVS 384

Query: 216 IGAGVDSYFEYLVKGAIL--LQDKKLMAMFLEYNKAIRNY---------TRFDDWYLWVQ 264
           +G   DS++EYL+K  ++    D +   M+ E  +AI  Y         T   +W   + 
Sbjct: 385 VGGLGDSFYEYLIKSWLMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWRGGIL 444

Query: 265 MYK---------GTVSMPVFQSLEAYWPGLQSLIGDIDNAMR-------TFLNYYTVWKQ 308
            +K         G +++    + E      + L   I            T L     W  
Sbjct: 445 DHKMGHLACFSGGMIALGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFN 504

Query: 309 FGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISK 368
            G       + + Y       Y LRPE++ES MYL+R T +P   E G + V ++EK  +
Sbjct: 505 SGREAVATQLSESY-------YILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCR 557

Query: 369 VECGFATIKDLRDH--KLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGE 426
            E GF+ I+D+       DN+ +SFFLAET+KYLYLLF   +                  
Sbjct: 558 TEAGFSGIQDVYSSTPNHDNKQQSFFLAETLKYLYLLFSEDD------------------ 599

Query: 427 CILGAGGYIFNTEAHPI 443
            +L    ++FNTEAHP+
Sbjct: 600 -LLSLEDWVFNTEAHPL 615


>gi|24497519 mannosidase, alpha, class 1A, member 1 [Homo sapiens]
          Length = 653

 Score =  166 bits (419), Expect = 7e-41
 Identities = 132/437 (30%), Positives = 212/437 (48%), Gaps = 65/437 (14%)

Query: 40  TLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKA 99
           T++DALDTL I+    EF+     +++++DF+++   SVFE NIR VGGLLSA+ LS   
Sbjct: 240 TIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISVFEVNIRFVGGLLSAYYLS--- 296

Query: 100 GVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNP----GETPVTCT 155
           G E+           + A E   KLLPAF TP+G+P+  +N+  G+           +  
Sbjct: 297 GEEI---------FRKKAVELGVKLLPAFHTPSGIPWALLNMKSGIGRNWPWASGGSSIL 347

Query: 156 AGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAG 215
           A  GT  +EF  LS L+G+P+F +        L +     GL  N+++  +G+W      
Sbjct: 348 AEFGTLHLEFMHLSHLSGNPIFAEKVMNIRTVLNKLEKPQGLYPNYLNPSSGQWGQHHVS 407

Query: 216 IGAGVDSYFEYLVKGAILLQDK---KLMAMFLEYNKAIRNY--TRFDDWYLWVQMYKGTV 270
           +G   DS++EYL+K A L+ DK   +   M+ +  +AI  +   +      ++  +KG +
Sbjct: 408 VGGLGDSFYEYLLK-AWLMSDKTDLEAKKMYFDAVQAIETHLIRKSSSGLTYIAEWKGGL 466

Query: 271 SMPVFQSLEAYWPGLQSLIGD--------------IDNAMRTFLNYYTVWKQFGGLPEFY 316
                  L  +  G+ +L  D               + A     +Y   + + G  PE +
Sbjct: 467 LEHKMGHLTCFAGGMFALGADAAPEGMAQHYLELGAEIARTCHESYNRTFMKLG--PEAF 524

Query: 317 NIPQGY----TVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECG 372
               G     T +  + Y LRPE++E+ MY++R T DP   +   +AVE++E   +V  G
Sbjct: 525 RFDGGVEAIATRQNEKYYILRPEVMETYMYMWRLTHDPKYRKWAWEAVEALENHCRVNGG 584

Query: 373 FATIKD--LRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILG 430
           ++ ++D  L     D+  +SFFLAET+KYLYL+F   +                   +L 
Sbjct: 585 YSGLRDVYLLHESYDDVQQSFFLAETLKYLYLIFSDDD-------------------LLP 625

Query: 431 AGGYIFNTEAH--PIDP 445
              +IFN+EAH  PI P
Sbjct: 626 LEHWIFNSEAHLLPILP 642


>gi|5729913 mannosidase, alpha, class 1A, member 2 [Homo sapiens]
          Length = 641

 Score =  165 bits (418), Expect = 9e-41
 Identities = 139/431 (32%), Positives = 204/431 (47%), Gaps = 59/431 (13%)

Query: 40  TLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKA 99
           T++DALDTL I+G   EF      ++D++DF ++   SVFE NIR +GGLL+A+ LS + 
Sbjct: 226 TIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYYLSGEE 285

Query: 100 GVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNP----GETPVTCT 155
             +++            A + A KLLPAF TPTG+P+  VNL  GV           +  
Sbjct: 286 IFKIK------------AVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASAGSSIL 333

Query: 156 AGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAG 215
           A  GT  +EF  LS LTGD  +          L +     GL  N+++  TG+W      
Sbjct: 334 AEFGTLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWGQYHTS 393

Query: 216 IGAGVDSYFEYLVKGAILLQDK---KLMAMFLEYNKAIRNY--TRFDDWYLWVQMYKGTV 270
           +G   DS++EYL+K A L+ DK   +   M+ +  +AI  +   +      ++  +K   
Sbjct: 394 VGGLGDSFYEYLLK-AWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGEWKNGH 452

Query: 271 SMPVFQSLEAYWPGLQSLIGDIDNA-------------MRTFLNYY--TVWKQFGGLPEF 315
                  L  +  G+ +L  D   A              RT    Y  T  K      +F
Sbjct: 453 LEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGPESFKF 512

Query: 316 YNIPQGYTVEKREG-YPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFA 374
               +   V + E  Y LRPE+IE+  YL+R T DP   + G +A  +IEK  +V  GF+
Sbjct: 513 DGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRVNGGFS 572

Query: 375 TIKDLRDH--KLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAG 432
            +KD+       D+  +SFFLAET+KYLYLLF                    G+ +L   
Sbjct: 573 GVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFS-------------------GDDLLPLD 613

Query: 433 GYIFNTEAHPI 443
            ++FNTEAHP+
Sbjct: 614 HWVFNTEAHPL 624


>gi|218749883 alpha 1,2-mannosidase [Homo sapiens]
          Length = 699

 Score =  155 bits (392), Expect = 9e-38
 Identities = 137/442 (30%), Positives = 212/442 (47%), Gaps = 66/442 (14%)

Query: 35  YSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHL 94
           +   LTLIDALDT+ ILG   EF+   + +   + F+ DV+ ++FE+ IR++GGLLSA+ 
Sbjct: 285 FGLGLTLIDALDTMWILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYH 344

Query: 95  LSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGV--NPGETPV 152
           LS                 LR AE+   +L+PAF+TP+ +PY  VN+  GV   P  T  
Sbjct: 345 LSG------------DSLFLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSD 392

Query: 153 TCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWE-SRSDIGLVGNHIDVLTGKWVA 211
           +  A + +  +EF  LS LTGD  F++        +   S    GLV   I+  +G +  
Sbjct: 393 STVAEVTSIQLEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTH 452

Query: 212 QDA-GIGAGVDSYFEYLVKGAIL--LQDKKLMAMFLEYNKAIR----NYTRFDDWYLWVQ 264
                +GA  DSY+EYL+K  I    Q+ +L+  ++E  + +R     ++         +
Sbjct: 453 LGVFTLGARADSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGE 512

Query: 265 MYKGTVSMPVFQSLEAYWPGLQSL-------IGDIDNAMRTFLNYYTVWKQF--GGLPE- 314
           +  G  S  +   L  + PG  +L          ++ A       Y + +Q   G  PE 
Sbjct: 513 LAHGRFSAKM-DHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEI 571

Query: 315 ----FYNIPQGYTVEKREG---YPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKIS 367
                Y  P    VE +       LRPE +ES  YLYR TGD    + G + ++S  + +
Sbjct: 572 VHFNLYPQPGRRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFT 631

Query: 368 KVEC-GFATIKDLRDHKLD---NRMESFFLAETVKYLYLLF--DPTNFIHNNGSTFDAVI 421
           +V   G+++I +++D +     ++MESFFL ET+KYL+LLF  DP               
Sbjct: 632 RVPSGGYSSINNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPN-------------- 677

Query: 422 TPYGECILGAGGYIFNTEAHPI 443
                 +L    Y+FNTEAHP+
Sbjct: 678 ------LLSLDAYVFNTEAHPL 693


>gi|53988380 mesothelin isoform 2 preproprotein [Homo sapiens]
          Length = 630

 Score = 32.3 bits (72), Expect = 1.1
 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 7/75 (9%)

Query: 80  ETNIRVVGGL---LSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLL----PAFQTPT 132
           E ++R +GGL   L    +++ A V +     C GPL +  +EAAR  L    P +  P+
Sbjct: 179 EADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPS 238

Query: 133 GMPYGTVNLLHGVNP 147
                T++ L G+ P
Sbjct: 239 TWSVSTMDALRGLLP 253


>gi|53988378 mesothelin isoform 1 preproprotein [Homo sapiens]
          Length = 622

 Score = 32.3 bits (72), Expect = 1.1
 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 7/75 (9%)

Query: 80  ETNIRVVGGL---LSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLL----PAFQTPT 132
           E ++R +GGL   L    +++ A V +     C GPL +  +EAAR  L    P +  P+
Sbjct: 179 EADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPS 238

Query: 133 GMPYGTVNLLHGVNP 147
                T++ L G+ P
Sbjct: 239 TWSVSTMDALRGLLP 253


>gi|18921093 transient receptor potential cation channel, subfamily M,
            member 6 [Homo sapiens]
          Length = 2022

 Score = 31.2 bits (69), Expect = 2.5
 Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 5/56 (8%)

Query: 450  CCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQ 505
            CC++LK     + DL R  YS +R  S F          EPPAR     SPE+  Q
Sbjct: 1971 CCRKLK-----LPDLKRNDYSPERINSTFGLEIKIESAEEPPARETGRNSPEDDMQ 2021


>gi|82775371 coiled-coil domain containing 93 [Homo sapiens]
          Length = 631

 Score = 30.4 bits (67), Expect = 4.3
 Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 11/70 (15%)

Query: 449 HCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARE 508
           HC + +   Q E+E+L  E         +  + T+SSG  EPP   GTL S   HD+  +
Sbjct: 406 HCREEMTRLQQEIENLKAE------RAPRGDEKTLSSG--EPP---GTLTSAMTHDEDLD 454

Query: 509 RKPAKQKVPL 518
           R+   +K  L
Sbjct: 455 RRYNMEKEKL 464


>gi|187171277 DNA-directed DNA polymerase gamma [Homo sapiens]
          Length = 1239

 Score = 30.0 bits (66), Expect = 5.6
 Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 2/80 (2%)

Query: 444 DPAALHCCQRLKEEQW--EVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPE 501
           D   L   +R KE+ W  ++E  ++EF   K  + K +  T S  P E    PG     E
Sbjct: 469 DACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQE 528

Query: 502 NHDQARERKPAKQKVPLLSC 521
           +     E +  +Q V   +C
Sbjct: 529 DLGPCSEEEEFQQDVMARAC 548


>gi|4505937 DNA-directed DNA polymerase gamma [Homo sapiens]
          Length = 1239

 Score = 30.0 bits (66), Expect = 5.6
 Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 2/80 (2%)

Query: 444 DPAALHCCQRLKEEQW--EVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPE 501
           D   L   +R KE+ W  ++E  ++EF   K  + K +  T S  P E    PG     E
Sbjct: 469 DACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQE 528

Query: 502 NHDQARERKPAKQKVPLLSC 521
           +     E +  +Q V   +C
Sbjct: 529 DLGPCSEEEEFQQDVMARAC 548


>gi|42476320 sushi domain containing 1 [Homo sapiens]
          Length = 747

 Score = 29.6 bits (65), Expect = 7.3
 Identities = 15/26 (57%), Positives = 16/26 (61%)

Query: 2  PFRLLIPLGLLCALLPQHHGAPGPDG 27
          P R L+PL LL  L     GAPGPDG
Sbjct: 10 PSRRLLPLLLLLGLARGAAGAPGPDG 35


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,444,962
Number of Sequences: 37866
Number of extensions: 1001721
Number of successful extensions: 2897
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2854
Number of HSP's gapped (non-prelim): 20
length of query: 541
length of database: 18,247,518
effective HSP length: 107
effective length of query: 434
effective length of database: 14,195,856
effective search space: 6161001504
effective search space used: 6161001504
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.