Search of human proteins with 222537737

Search of human proteins with 222537737

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|222537737 ER degradation enhancer, mannosidase alpha-like 2
isoform 1 [Homo sapiens]
         (578 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|222537737 ER degradation enhancer, mannosidase alpha-like 2 i...  1187   0.0  
gi|222537739 ER degradation enhancer, mannosidase alpha-like 2 i...  1086   0.0  
gi|7662002 ER degradation enhancer, mannosidase alpha-like 1 [Ho...   355   6e-98
gi|163310725 ER degradation enhancer, mannosidase alpha-like 3 [...   320   3e-87
gi|5729913 mannosidase, alpha, class 1A, member 2 [Homo sapiens]      193   4e-49
gi|9966903 mannosidase, alpha, class 1C, member 1 [Homo sapiens]      190   3e-48
gi|24497519 mannosidase, alpha, class 1A, member 1 [Homo sapiens]     186   4e-47
gi|218749883 alpha 1,2-mannosidase [Homo sapiens]                     173   4e-43
gi|53988380 mesothelin isoform 2 preproprotein [Homo sapiens]          32   1.2  
gi|53988378 mesothelin isoform 1 preproprotein [Homo sapiens]          32   1.2  
gi|18921093 transient receptor potential cation channel, subfami...    31   2.7  
gi|82775371 coiled-coil domain containing 93 [Homo sapiens]            30   4.6  
gi|187171277 DNA-directed DNA polymerase gamma [Homo sapiens]          30   6.1  
gi|4505937 DNA-directed DNA polymerase gamma [Homo sapiens]            30   6.1  
gi|42476320 sushi domain containing 1 [Homo sapiens]                   30   7.9  

>gi|222537737 ER degradation enhancer, mannosidase alpha-like 2
           isoform 1 [Homo sapiens]
          Length = 578

 Score = 1187 bits (3070), Expect = 0.0
 Identities = 578/578 (100%), Positives = 578/578 (100%)

Query: 1   MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDEL 60
           MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDEL
Sbjct: 1   MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDEL 60

Query: 61  RPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNI 120
           RPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNI
Sbjct: 61  RPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNI 120

Query: 121 RVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLH 180
           RVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLH
Sbjct: 121 RVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLH 180

Query: 181 GVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHID 240
           GVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHID
Sbjct: 181 GVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHID 240

Query: 241 VLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWV 300
           VLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWV
Sbjct: 241 VLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWV 300

Query: 301 QMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYT 360
           QMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYT
Sbjct: 301 QMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYT 360

Query: 361 VEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHK 420
           VEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHK
Sbjct: 361 VEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHK 420

Query: 421 LDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPI 480
           LDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPI
Sbjct: 421 LDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPI 480

Query: 481 DPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENH 540
           DPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENH
Sbjct: 481 DPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENH 540

Query: 541 DQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS 578
           DQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS
Sbjct: 541 DQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS 578


>gi|222537739 ER degradation enhancer, mannosidase alpha-like 2
           isoform 2 [Homo sapiens]
          Length = 541

 Score = 1086 bits (2809), Expect = 0.0
 Identities = 541/578 (93%), Positives = 541/578 (93%), Gaps = 37/578 (6%)

Query: 1   MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDEL 60
           MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHY                         
Sbjct: 1   MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHY------------------------- 35

Query: 61  RPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNI 120
                       SFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNI
Sbjct: 36  ------------SFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNI 83

Query: 121 RVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLH 180
           RVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLH
Sbjct: 84  RVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLH 143

Query: 181 GVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHID 240
           GVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHID
Sbjct: 144 GVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHID 203

Query: 241 VLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWV 300
           VLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWV
Sbjct: 204 VLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWV 263

Query: 301 QMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYT 360
           QMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYT
Sbjct: 264 QMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYT 323

Query: 361 VEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHK 420
           VEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHK
Sbjct: 324 VEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHK 383

Query: 421 LDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPI 480
           LDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPI
Sbjct: 384 LDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPI 443

Query: 481 DPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENH 540
           DPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENH
Sbjct: 444 DPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENH 503

Query: 541 DQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS 578
           DQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS
Sbjct: 504 DQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS 541


>gi|7662002 ER degradation enhancer, mannosidase alpha-like 1 [Homo
           sapiens]
          Length = 657

 Score =  355 bits (911), Expect = 6e-98
 Identities = 214/525 (40%), Positives = 305/525 (58%), Gaps = 64/525 (12%)

Query: 33  AHYRERVKAMFYHAYDSYLENAFPFDELRPLTCDG-------------HDTWGSFSLTLI 79
           A  R+  + MF   YD+Y+ +AFP DEL P+ C G             +D  G++SLTL+
Sbjct: 128 AQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLGNYSLTLV 187

Query: 80  DALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLL---SKKA 136
           DALDTL I+GN SEFQ+ V+++ ++V FD D    VFE  IRV+G LLSAH +   SK+ 
Sbjct: 188 DALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRIITDSKQP 247

Query: 137 GVEVEAGWPCSGPLLRMAEEAARKLLPAFQ-TPTGMPYGTVNLLHGVNPGETPVTCTAGI 195
             ++         LL MA + A +LLPAF+ T TG+PY  VNL  GV P     TCTAG 
Sbjct: 248 FGDMTIK-DYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPDTNNETCTAGA 306

Query: 196 GTFIVEFATLSSLTGDPVFEDVARVALMRLWESRS-DIGLVGNHIDVLTGKWVAQDAGIG 254
           G+ +VEF  LS L GD  FE VAR A+  LW  RS D GL+GN +++ TG WV + +G+G
Sbjct: 307 GSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVGKQSGLG 366

Query: 255 AGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFD-----------DWYLWVQMY 303
           AG+DS++EYL+K  IL  +K+ + MF    ++I+NY R               Y+ V M+
Sbjct: 367 AGLDSFYEYLLKSYILFGEKEDLEMFNAAYQSIQNYLRRGREACNEGEGDPPLYVNVNMF 426

Query: 304 KGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEK 363
            G +      SL+A++PGLQ LIGD+++A+     YY +WK++G LPE YN    + ++ 
Sbjct: 427 SGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYN----WQLQA 482

Query: 364 REG--YPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKL 421
            +   YPLRPEL+ES   LY+AT +P  L +G D ++S+EK +KV+CG+AT+  + D   
Sbjct: 483 PDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKCGYATLHHVIDKST 542

Query: 422 DNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPID 481
           ++RMESFFL+ET KYLYLLFD  N +H +G+                  Y+F TE H + 
Sbjct: 543 EDRMESFFLSETCKYLYLLFDEDNPVHKSGTR-----------------YMFTTEGHIVS 585

Query: 482 PAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWE 526
                  + L+E  W      +EF+S +  + +  K+     P E
Sbjct: 586 -----VDEHLRELPW------KEFFSEEGGQDQGGKSVHRPKPHE 619


>gi|163310725 ER degradation enhancer, mannosidase alpha-like 3
           [Homo sapiens]
          Length = 932

 Score =  320 bits (819), Expect = 3e-87
 Identities = 196/460 (42%), Positives = 261/460 (56%), Gaps = 39/460 (8%)

Query: 38  RVKAMFYHAYDSYLENAFPFDELRPLTCDGH------------DTWGSFSLTLIDALDTL 85
           +V  MF HAY +Y+E+A+P DEL PLTC G             D  G FSLTLID+LDTL
Sbjct: 55  QVLEMFDHAYGNYMEHAYPADELMPLTCRGRVRGQEPSRGDVDDALGKFSLTLIDSLDTL 114

Query: 86  LILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWP 145
           ++L    EF+  V  +   V+ D DV  SVFETNIRV+GGLL  H L+     + E    
Sbjct: 115 VVLNKTKEFEDAVRKVLRDVNLDNDVVVSVFETNIRVLGGLLGGHSLAIMLKEKGEYMQW 174

Query: 146 CSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPV-----TCTAGIGTFIV 200
            +  LL+MA++   KLLPAF T +G+PY  +NL  G+   E        TCTA  GT I+
Sbjct: 175 YNDELLQMAKQLGYKLLPAFNTTSGLPYPRINLKFGIRKPEARTGTETDTCTACAGTLIL 234

Query: 201 EFATLSSLTGDPVFEDVARVALMRLWESRS-DIGLVGNHIDVLTGKWVAQDAGIGAGVDS 259
           EFA LS  TG  +FE+ AR AL  LWE R     LVG  I++ TG WV +D+G+GAG+DS
Sbjct: 235 EFAALSRFTGATIFEEYARKALDFLWEKRQRSSNLVGVTINIHTGDWVRKDSGVGAGIDS 294

Query: 260 YFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQ-SLEAY 318
           Y+EYL+K  +LL D   +  F  +  AI  Y       L V ++K  ++   +  +L A+
Sbjct: 295 YYEYLLKAYVLLGDDSFLERFNTHYDAIMRYISQPPLLLDVHIHKPMLNARTWMDALLAF 354

Query: 319 WPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAM 378
           +PGLQ L GDI  A+ T    Y V K+   LPE +     + V   + +PLRPE  ES  
Sbjct: 355 FPGLQVLKGDIRPAIETHEMLYQVIKKHNFLPEAFTTD--FRVHWAQ-HPLRPEFAESTY 411

Query: 379 YLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLY 438
           +LY+ATGDP  LE+G+  +E++ K ++V CGFA +KD+R    ++RM+SFFLAE  KYLY
Sbjct: 412 FLYKATGDPYYLEVGKTLIENLNKYARVPCGFAAMKDVRTGSHEDRMDSFFLAEMFKYLY 471

Query: 439 LLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAH 478
           LLF                     + I     YIF TEAH
Sbjct: 472 LLFADKE-----------------DIIFDIEDYIFTTEAH 494


>gi|5729913 mannosidase, alpha, class 1A, member 2 [Homo sapiens]
          Length = 641

 Score =  193 bits (490), Expect = 4e-49
 Identities = 160/496 (32%), Positives = 236/496 (47%), Gaps = 63/496 (12%)

Query: 16  LPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDELRPLTCDGH--DTWGS 73
           +P   G  G D    D    RE++K M  HA+D+Y    +  +ELRP+   GH  + +GS
Sbjct: 161 IPNLVGIRGGDPEDNDIREKREKIKEMMKHAWDNYRTYGWGHNELRPIARKGHSPNIFGS 220

Query: 74  FSL--TLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHL 131
             +  T++DALDTL I+G   EF      ++D++DF ++   SVFE NIR +GGLL+A+ 
Sbjct: 221 SQMGATIVDALDTLYIMGLHDEFLDGQRWIEDNLDFSVNSEVSVFEVNIRFIGGLLAAYY 280

Query: 132 LSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNP----GET 187
           LS +   +++            A + A KLLPAF TPTG+P+  VNL  GV         
Sbjct: 281 LSGEEIFKIK------------AVQLAEKLLPAFNTPTGIPWAMVNLKSGVGRNWGWASA 328

Query: 188 PVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWV 247
             +  A  GT  +EF  LS LTGD  +          L +     GL  N+++  TG+W 
Sbjct: 329 GSSILAEFGTLHMEFIHLSYLTGDLTYYKKVMHIRKLLQKMDRPNGLYPNYLNPRTGRWG 388

Query: 248 AQDAGIGAGVDSYFEYLVKGAILLQDK---KLMAMFLEYNKAIRNY--TRFDDWYLWVQM 302
                +G   DS++EYL+K A L+ DK   +   M+ +  +AI  +   +      ++  
Sbjct: 389 QYHTSVGGLGDSFYEYLLK-AWLMSDKTDHEARKMYDDAIEAIEKHLIKKSRGGLTFIGE 447

Query: 303 YKGTVSMPVFQSLEAYWPGLQSLIGDIDNA-------------MRTFLNYY--TVWKQFG 347
           +K          L  +  G+ +L  D   A              RT    Y  T  K   
Sbjct: 448 WKNGHLEKKMGHLACFAGGMFALGADGSRADKAGHYLELGAEIARTCHESYDRTALKLGP 507

Query: 348 GLPEFYNIPQGYTVEKREG-YPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKV 406
              +F    +   V + E  Y LRPE+IE+  YL+R T DP   + G +A  +IEK  +V
Sbjct: 508 ESFKFDGAVEAVAVRQAEKYYILRPEVIETYWYLWRFTHDPRYRQWGWEAALAIEKYCRV 567

Query: 407 ECGFATIKDLRDH--KLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGEC 464
             GF+ +KD+       D+  +SFFLAET+KYLYLLF                    G+ 
Sbjct: 568 NGGFSGVKDVYSSTPTHDDVQQSFFLAETLKYLYLLFS-------------------GDD 608

Query: 465 ILGAGGYIFNTEAHPI 480
           +L    ++FNTEAHP+
Sbjct: 609 LLPLDHWVFNTEAHPL 624


>gi|9966903 mannosidase, alpha, class 1C, member 1 [Homo sapiens]
          Length = 630

 Score =  190 bits (483), Expect = 3e-48
 Identities = 150/481 (31%), Positives = 225/481 (46%), Gaps = 76/481 (15%)

Query: 36  RERVKAMFYHAYDSYLENAFPFDELRPLTCDGHD--TWGSFS-LTLIDALDTLLILGNVS 92
           RE++K M   A+ SY   A   +ELRPLT DG++   +G  S  T+ID+LDTL ++    
Sbjct: 175 REKIKEMMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELKE 234

Query: 93  EFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLR 152
           EFQ     + +S   ++   AS+FE NIR +GGLLSA  L+ +    ++A        +R
Sbjct: 235 EFQEAKAWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKA--------IR 286

Query: 153 MAEEAARKLLPAFQTPTGMPYGTVNLLHG----VNPGETPVTCTAGIGTFIVEFATLSSL 208
           + E    KLLPAF TPTG+P G V+   G       G + +   A  G+  +EF  L+ L
Sbjct: 287 LGE----KLLPAFNTPTGIPKGVVSFKSGNWGWATAGSSSI--LAEFGSLHLEFLHLTEL 340

Query: 209 TGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGA 268
           +G+ VF +  R     L +     GL  N +  ++G WV     +G   DS++EYL+K  
Sbjct: 341 SGNQVFAEKVRNIRKVLRKIEKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSW 400

Query: 269 IL--LQDKKLMAMFLEYNKAIRNY---------TRFDDWYLWVQMYK---------GTVS 308
           ++    D +   M+ E  +AI  Y         T   +W   +  +K         G ++
Sbjct: 401 LMSGKTDMEAKNMYYEALEAIETYLLNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIA 460

Query: 309 MPVFQSLEAYWPGLQSLIGDIDNAMR-------TFLNYYTVWKQFGGLPEFYNIPQGYTV 361
           +    + E      + L   I            T L     W   G       + + Y  
Sbjct: 461 LGAEDAKEEKRAHYRELAAQITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESY-- 518

Query: 362 EKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDH-- 419
                Y LRPE++ES MYL+R T +P   E G + V ++EK  + E GF+ I+D+     
Sbjct: 519 -----YILRPEVVESYMYLWRQTHNPIYREWGWEVVLALEKYCRTEAGFSGIQDVYSSTP 573

Query: 420 KLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHP 479
             DN+ +SFFLAET+KYLYLLF   +                   +L    ++FNTEAHP
Sbjct: 574 NHDNKQQSFFLAETLKYLYLLFSEDD-------------------LLSLEDWVFNTEAHP 614

Query: 480 I 480
           +
Sbjct: 615 L 615


>gi|24497519 mannosidase, alpha, class 1A, member 1 [Homo sapiens]
          Length = 653

 Score =  186 bits (473), Expect = 4e-47
 Identities = 154/518 (29%), Positives = 251/518 (48%), Gaps = 79/518 (15%)

Query: 2   PFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRER---VKAMFYHAYDSYLENAFPFD 58
           PFR L P+  +  +        G +   P  A  RE+   +K M  HA+++Y   A+  +
Sbjct: 167 PFRGLPPVDFVPPI--------GVESREPADAAIREKRAKIKEMMKHAWNNYKGYAWGLN 218

Query: 59  ELRPLTCDGHDT--WGSFS-LTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASV 115
           EL+P++  GH +  +G+    T++DALDTL I+    EF+     +++++DF+++   SV
Sbjct: 219 ELKPISKGGHSSSLFGNIKGATIVDALDTLFIMEMKHEFEEAKSWVEENLDFNVNAEISV 278

Query: 116 FETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGT 175
           FE NIR VGGLLSA+ LS   G E+           + A E   KLLPAF TP+G+P+  
Sbjct: 279 FEVNIRFVGGLLSAYYLS---GEEI---------FRKKAVELGVKLLPAFHTPSGIPWAL 326

Query: 176 VNLLHGVNP----GETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSD 231
           +N+  G+           +  A  GT  +EF  LS L+G+P+F +        L +    
Sbjct: 327 LNMKSGIGRNWPWASGGSSILAEFGTLHLEFMHLSHLSGNPIFAEKVMNIRTVLNKLEKP 386

Query: 232 IGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDK---KLMAMFLEYNKAIR 288
            GL  N+++  +G+W      +G   DS++EYL+K A L+ DK   +   M+ +  +AI 
Sbjct: 387 QGLYPNYLNPSSGQWGQHHVSVGGLGDSFYEYLLK-AWLMSDKTDLEAKKMYFDAVQAIE 445

Query: 289 NY--TRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGD--------------IDNA 332
            +   +      ++  +KG +       L  +  G+ +L  D               + A
Sbjct: 446 THLIRKSSSGLTYIAEWKGGLLEHKMGHLTCFAGGMFALGADAAPEGMAQHYLELGAEIA 505

Query: 333 MRTFLNYYTVWKQFGGLPEFYNIPQGY----TVEKREGYPLRPELIESAMYLYRATGDPT 388
                +Y   + + G  PE +    G     T +  + Y LRPE++E+ MY++R T DP 
Sbjct: 506 RTCHESYNRTFMKLG--PEAFRFDGGVEAIATRQNEKYYILRPEVMETYMYMWRLTHDPK 563

Query: 389 LLELGRDAVESIEKISKVECGFATIKD--LRDHKLDNRMESFFLAETVKYLYLLFDPTNF 446
             +   +AVE++E   +V  G++ ++D  L     D+  +SFFLAET+KYLYL+F   + 
Sbjct: 564 YRKWAWEAVEALENHCRVNGGYSGLRDVYLLHESYDDVQQSFFLAETLKYLYLIFSDDD- 622

Query: 447 IHNNGSTFDAVITPYGECILGAGGYIFNTEAH--PIDP 482
                             +L    +IFN+EAH  PI P
Sbjct: 623 ------------------LLPLEHWIFNSEAHLLPILP 642


>gi|218749883 alpha 1,2-mannosidase [Homo sapiens]
          Length = 699

 Score =  173 bits (438), Expect = 4e-43
 Identities = 152/492 (30%), Positives = 236/492 (47%), Gaps = 68/492 (13%)

Query: 23  PGPDGSAPDPAHYRER-VKAMFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDA 81
           P      P   +YR++ V  +F HA+  Y + A+  DEL+P++      W    LTLIDA
Sbjct: 236 PARTQGTPVHLNYRQKGVIDVFLHAWKGYRKFAWGHDELKPVS-RSFSEWFGLGLTLIDA 294

Query: 82  LDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVE 141
           LDT+ ILG   EF+   + +   + F+ DV+ ++FE+ IR++GGLLSA+ LS        
Sbjct: 295 LDTMWILGLRKEFEEARKWVSKKLHFEKDVDVNLFESTIRILGGLLSAYHLSG------- 347

Query: 142 AGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGV--NPGETPVTCTAGIGTFI 199
                    LR AE+   +L+PAF+TP+ +PY  VN+  GV   P  T  +  A + +  
Sbjct: 348 -----DSLFLRKAEDFGNRLMPAFRTPSKIPYSDVNIGTGVAHPPRWTSDSTVAEVTSIQ 402

Query: 200 VEFATLSSLTGDPVFEDVARVALMRLWE-SRSDIGLVGNHIDVLTGKWVAQDA-GIGAGV 257
           +EF  LS LTGD  F++        +   S    GLV   I+  +G +       +GA  
Sbjct: 403 LEFRELSRLTGDKKFQEAVEKVTQHIHGLSGKKDGLVPMFINTHSGLFTHLGVFTLGARA 462

Query: 258 DSYFEYLVKGAIL--LQDKKLMAMFLEYNKAIR----NYTRFDDWYLWVQMYKGTVSMPV 311
           DSY+EYL+K  I    Q+ +L+  ++E  + +R     ++         ++  G  S  +
Sbjct: 463 DSYYEYLLKQWIQGGKQETQLLEDYVEAIEGVRTHLLRHSEPSKLTFVGELAHGRFSAKM 522

Query: 312 FQSLEAYWPGLQSL-------IGDIDNAMRTFLNYYTVWKQF--GGLPE-----FYNIPQ 357
              L  + PG  +L          ++ A       Y + +Q   G  PE      Y  P 
Sbjct: 523 -DHLVCFLPGTLALGVYHGLPASHMELAQELMETCYQMNRQMETGLSPEIVHFNLYPQPG 581

Query: 358 GYTVEKREG---YPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVEC-GFATI 413
              VE +       LRPE +ES  YLYR TGD    + G + ++S  + ++V   G+++I
Sbjct: 582 RRDVEVKPADRHNLLRPETVESLFYLYRVTGDRKYQDWGWEILQSFSRFTRVPSGGYSSI 641

Query: 414 KDLRDHKLD---NRMESFFLAETVKYLYLLF--DPTNFIHNNGSTFDAVITPYGECILGA 468
            +++D +     ++MESFFL ET+KYL+LLF  DP                     +L  
Sbjct: 642 NNVQDPQKPEPRDKMESFFLGETLKYLFLLFSDDPN--------------------LLSL 681

Query: 469 GGYIFNTEAHPI 480
             Y+FNTEAHP+
Sbjct: 682 DAYVFNTEAHPL 693


>gi|53988380 mesothelin isoform 2 preproprotein [Homo sapiens]
          Length = 630

 Score = 32.3 bits (72), Expect = 1.2
 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 7/75 (9%)

Query: 117 ETNIRVVGGL---LSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLL----PAFQTPT 169
           E ++R +GGL   L    +++ A V +     C GPL +  +EAAR  L    P +  P+
Sbjct: 179 EADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPS 238

Query: 170 GMPYGTVNLLHGVNP 184
                T++ L G+ P
Sbjct: 239 TWSVSTMDALRGLLP 253


>gi|53988378 mesothelin isoform 1 preproprotein [Homo sapiens]
          Length = 622

 Score = 32.3 bits (72), Expect = 1.2
 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 7/75 (9%)

Query: 117 ETNIRVVGGL---LSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLL----PAFQTPT 169
           E ++R +GGL   L    +++ A V +     C GPL +  +EAAR  L    P +  P+
Sbjct: 179 EADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPS 238

Query: 170 GMPYGTVNLLHGVNP 184
                T++ L G+ P
Sbjct: 239 TWSVSTMDALRGLLP 253


>gi|18921093 transient receptor potential cation channel, subfamily M,
            member 6 [Homo sapiens]
          Length = 2022

 Score = 31.2 bits (69), Expect = 2.7
 Identities = 21/56 (37%), Positives = 26/56 (46%), Gaps = 5/56 (8%)

Query: 487  CCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQ 542
            CC++LK     + DL R  YS +R  S F          EPPAR     SPE+  Q
Sbjct: 1971 CCRKLK-----LPDLKRNDYSPERINSTFGLEIKIESAEEPPARETGRNSPEDDMQ 2021


>gi|82775371 coiled-coil domain containing 93 [Homo sapiens]
          Length = 631

 Score = 30.4 bits (67), Expect = 4.6
 Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 11/70 (15%)

Query: 486 HCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARE 545
           HC + +   Q E+E+L  E         +  + T+SSG  EPP   GTL S   HD+  +
Sbjct: 406 HCREEMTRLQQEIENLKAE------RAPRGDEKTLSSG--EPP---GTLTSAMTHDEDLD 454

Query: 546 RKPAKQKVPL 555
           R+   +K  L
Sbjct: 455 RRYNMEKEKL 464


>gi|187171277 DNA-directed DNA polymerase gamma [Homo sapiens]
          Length = 1239

 Score = 30.0 bits (66), Expect = 6.1
 Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 2/80 (2%)

Query: 481 DPAALHCCQRLKEEQW--EVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPE 538
           D   L   +R KE+ W  ++E  ++EF   K  + K +  T S  P E    PG     E
Sbjct: 469 DACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQE 528

Query: 539 NHDQARERKPAKQKVPLLSC 558
           +     E +  +Q V   +C
Sbjct: 529 DLGPCSEEEEFQQDVMARAC 548


>gi|4505937 DNA-directed DNA polymerase gamma [Homo sapiens]
          Length = 1239

 Score = 30.0 bits (66), Expect = 6.1
 Identities = 22/80 (27%), Positives = 34/80 (42%), Gaps = 2/80 (2%)

Query: 481 DPAALHCCQRLKEEQW--EVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPE 538
           D   L   +R KE+ W  ++E  ++EF   K  + K +  T S  P E    PG     E
Sbjct: 469 DACQLLSGERYKEDPWLWDLEWDLQEFKQKKAKKVKKEPATASKLPIEGAGAPGDPMDQE 528

Query: 539 NHDQARERKPAKQKVPLLSC 558
           +     E +  +Q V   +C
Sbjct: 529 DLGPCSEEEEFQQDVMARAC 548


>gi|42476320 sushi domain containing 1 [Homo sapiens]
          Length = 747

 Score = 29.6 bits (65), Expect = 7.9
 Identities = 15/26 (57%), Positives = 16/26 (61%)

Query: 2  PFRLLIPLGLLCALLPQHHGAPGPDG 27
          P R L+PL LL  L     GAPGPDG
Sbjct: 10 PSRRLLPLLLLLGLARGAAGAPGPDG 35


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.139    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,996,066
Number of Sequences: 37866
Number of extensions: 1083480
Number of successful extensions: 2996
Number of sequences better than 10.0: 15
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2947
Number of HSP's gapped (non-prelim): 20
length of query: 578
length of database: 18,247,518
effective HSP length: 108
effective length of query: 470
effective length of database: 14,157,990
effective search space: 6654255300
effective search space used: 6654255300
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.