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Search of human proteins with 222352145
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222352145 serine/threonine/tyrosine kinase 1 [Homo sapiens]
(422 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222352145 serine/threonine/tyrosine kinase 1 [Homo sapiens] 848 0.0
gi|254028242 fibroblast growth factor receptor 3 isoform 3 precu... 167 2e-41
gi|4503711 fibroblast growth factor receptor 3 isoform 1 precurs... 167 2e-41
gi|13112048 fibroblast growth factor receptor 3 isoform 2 precur... 166 3e-41
gi|222144241 fibroblast growth factor receptor 2 isoform 8 precu... 163 2e-40
gi|222144239 fibroblast growth factor receptor 2 isoform 7 precu... 162 5e-40
gi|13186236 fibroblast growth factor receptor 1 isoform 4 precur... 162 5e-40
gi|13186234 fibroblast growth factor receptor 1 isoform 3 precur... 162 5e-40
gi|13186251 fibroblast growth factor receptor 1 isoform 2 precur... 162 5e-40
gi|105990522 fibroblast growth factor receptor 1 isoform 1 precu... 162 5e-40
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur... 160 2e-39
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur... 160 2e-39
gi|222144237 fibroblast growth factor receptor 2 isoform 6 precu... 159 5e-39
gi|222144233 fibroblast growth factor receptor 2 isoform 4 precu... 159 5e-39
gi|221316639 fibroblast growth factor receptor 2 isoform 1 precu... 159 5e-39
gi|221316638 fibroblast growth factor receptor 2 isoform 2 precu... 159 5e-39
gi|222144244 fibroblast growth factor receptor 2 isoform 9 precu... 157 1e-38
gi|222144231 fibroblast growth factor receptor 2 isoform 3 precu... 157 1e-38
gi|222144235 fibroblast growth factor receptor 2 isoform 5 precu... 157 1e-38
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur... 157 2e-38
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 156 3e-38
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 156 3e-38
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 155 5e-38
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 155 8e-38
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 155 8e-38
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 155 8e-38
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 155 8e-38
gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like... 142 4e-34
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo... 137 2e-32
gi|187475373 c-src tyrosine kinase [Homo sapiens] 136 4e-32
>gi|222352145 serine/threonine/tyrosine kinase 1 [Homo sapiens]
Length = 422
Score = 848 bits (2190), Expect = 0.0
Identities = 422/422 (100%), Positives = 422/422 (100%)
Query: 1 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG 60
MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG
Sbjct: 1 MGMTRMLLECSLSDKLCVIQEKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSG 60
Query: 61 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI 120
PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI
Sbjct: 61 PQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQI 120
Query: 121 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL 180
CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL
Sbjct: 121 CSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQL 180
Query: 181 EGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE 240
EGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE
Sbjct: 181 EGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALE 240
Query: 241 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL 300
FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL
Sbjct: 241 FLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWLAPERLLL 300
Query: 301 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK 360
RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK
Sbjct: 301 RPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMK 360
Query: 361 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS 420
SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS
Sbjct: 361 SCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPELVVPELYAAVAGIRVESLFYNYS 420
Query: 421 ML 422
ML
Sbjct: 421 ML 422
>gi|254028242 fibroblast growth factor receptor 3 isoform 3
precursor [Homo sapiens]
Length = 808
Score = 167 bits (423), Expect = 2e-41
Identities = 107/346 (30%), Positives = 178/346 (51%), Gaps = 19/346 (5%)
Query: 64 IAPVPPPRDLSWEAGHGGNVALPLKETS-VENFLGATTPALAKLQVP----------REQ 112
I+ P R +S E+ + PL + + + G T +++L++P R
Sbjct: 416 ISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLT 475
Query: 113 LSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLG 172
L + L + C G ++ +KP +V +K LK+ A ++ D + ++ + +G
Sbjct: 476 LGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIG 535
Query: 173 KHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVM-----TMDGLLYDLTEKQ 227
KHKN++ L G CT+ PLY+++E A+G+L FL R + T LT K
Sbjct: 536 KHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKD 595
Query: 228 VYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT 287
+ QV +E+L + H D+AARN+L+ D K+ GLA +V+ T
Sbjct: 596 LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTN 655
Query: 288 --IPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIM 345
+P+KW+APE L R + ++DVWSFG+LL+E+ TLG PYP +P + + L+ M
Sbjct: 656 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRM 715
Query: 346 KRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIK-TADDE 390
+P++CTH +Y IM+ CW + RP+ ++L L+ + T+ DE
Sbjct: 716 DKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDE 761
>gi|4503711 fibroblast growth factor receptor 3 isoform 1 precursor
[Homo sapiens]
Length = 806
Score = 167 bits (423), Expect = 2e-41
Identities = 107/346 (30%), Positives = 178/346 (51%), Gaps = 19/346 (5%)
Query: 64 IAPVPPPRDLSWEAGHGGNVALPLKETS-VENFLGATTPALAKLQVP----------REQ 112
I+ P R +S E+ + PL + + + G T +++L++P R
Sbjct: 414 ISRFPLKRQVSLESNASMSSNTPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLT 473
Query: 113 LSEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLG 172
L + L + C G ++ +KP +V +K LK+ A ++ D + ++ + +G
Sbjct: 474 LGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIG 533
Query: 173 KHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVM-----TMDGLLYDLTEKQ 227
KHKN++ L G CT+ PLY+++E A+G+L FL R + T LT K
Sbjct: 534 KHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKD 593
Query: 228 VYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT 287
+ QV +E+L + H D+AARN+L+ D K+ GLA +V+ T
Sbjct: 594 LVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTN 653
Query: 288 --IPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIM 345
+P+KW+APE L R + ++DVWSFG+LL+E+ TLG PYP +P + + L+ M
Sbjct: 654 GRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRM 713
Query: 346 KRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIK-TADDE 390
+P++CTH +Y IM+ CW + RP+ ++L L+ + T+ DE
Sbjct: 714 DKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDE 759
>gi|13112048 fibroblast growth factor receptor 3 isoform 2 precursor
[Homo sapiens]
Length = 694
Score = 166 bits (421), Expect = 3e-41
Identities = 99/300 (33%), Positives = 162/300 (54%), Gaps = 10/300 (3%)
Query: 101 PALAKLQVPREQLS--EVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEV 158
PA K ++ R +L+ + L + C G ++ +KP +V +K LK+ A ++
Sbjct: 348 PADPKWELSRARLTLGKPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDL 407
Query: 159 QDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVM---- 214
D + ++ + +GKHKN++ L G CT+ PLY+++E A+G+L FL R +
Sbjct: 408 SDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSF 467
Query: 215 -TMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLA 273
T LT K + QV +E+L + H D+AARN+L+ D K+ GLA
Sbjct: 468 DTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLA 527
Query: 274 YEVYTRGAISSTQT--IPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVP 331
+V+ T +P+KW+APE L R + ++DVWSFG+LL+E+ TLG PYP +P
Sbjct: 528 RDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIP 587
Query: 332 PTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIK-TADDE 390
+ + L+ M +P++CTH +Y IM+ CW + RP+ ++L L+ + T+ DE
Sbjct: 588 VEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVTSTDE 647
>gi|222144241 fibroblast growth factor receptor 2 isoform 8
precursor [Homo sapiens]
Length = 704
Score = 163 bits (413), Expect = 2e-40
Identities = 111/394 (28%), Positives = 193/394 (48%), Gaps = 34/394 (8%)
Query: 34 VTIFLILLGVILWLFIREQRTQQQRSGPQGIAP------VPPPRDLSWEAGHGGNVALPL 87
+ +FLI V+ + R + T ++ A +P R +S E+ N PL
Sbjct: 268 IGVFLIACMVVTVILCRMKNTTKKPDFSSQPAVHKLTKRIPLRRQVSAESSSSMNSNTPL 327
Query: 88 KETSVENFLGATTPALA-----------KLQVPREQLSEVLEQICSGSCGPIFRANMNTG 136
+ A TP LA K + PR++L+ + + + G G + A
Sbjct: 328 VRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT-LGKPLGEGCFGQVVMAEAVGI 386
Query: 137 DPSKPK---SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMV 193
D KPK +V +K LK+ A ++ D + ++ + +GKHKN++ L G CT+ PLY++
Sbjct: 387 DKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVI 446
Query: 194 LEDVAQGDLLSFLWTCRRDVMTMDGLLYDL--------TEKQVYHIGKQVLLALEFLQEK 245
+E ++G+L +L R M YD+ T K + Q+ +E+L +
Sbjct: 447 VEYASKGNLREYLRARRPPGMEYS---YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQ 503
Query: 246 HLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--IPLKWLAPERLLLRPA 303
H D+AARN+L+ + K+ GLA ++ T +P+KW+APE L R
Sbjct: 504 KCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVY 563
Query: 304 SIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCW 363
+ ++DVWSFG+L++E+ TLG PYP +P + + L+ M +P++CT+ +Y +M+ CW
Sbjct: 564 THQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCW 623
Query: 364 RWREADRPSPRELRLRLEAAIKTADDEAVLQVPE 397
+ RP+ ++L L+ + +E L + +
Sbjct: 624 HAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQ 657
>gi|222144239 fibroblast growth factor receptor 2 isoform 7
precursor [Homo sapiens]
Length = 705
Score = 162 bits (410), Expect = 5e-40
Identities = 107/374 (28%), Positives = 185/374 (49%), Gaps = 29/374 (7%)
Query: 48 FIREQRTQQQRSGPQGIAPVPPPRDLSWEAGHGGNVALPLKETSVENFLGATTPALA--- 104
+I+ + GP G+ P +S E+ N PL + A TP LA
Sbjct: 290 WIKHVEKNGSKYGPDGL-PYLKVLKVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVS 348
Query: 105 --------KLQVPREQLSEVLEQICSGSCGPIFRANMNTGDPSKPK---SVILKALKEPA 153
K + PR++L+ + + + G G + A D KPK +V +K LK+ A
Sbjct: 349 EYELPEDPKWEFPRDKLT-LGKPLGEGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDA 407
Query: 154 GLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDV 213
++ D + ++ + +GKHKN++ L G CT+ PLY+++E ++G+L +L R
Sbjct: 408 TEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPG 467
Query: 214 MTMDGLLYDL--------TEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTA 265
M YD+ T K + Q+ +E+L + H D+AARN+L+ +
Sbjct: 468 MEYS---YDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVM 524
Query: 266 KLCGLGLAYEVYTRGAISSTQT--IPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLG 323
K+ GLA ++ T +P+KW+APE L R + ++DVWSFG+L++E+ TLG
Sbjct: 525 KIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLG 584
Query: 324 APPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAA 383
PYP +P + + L+ M +P++CT+ +Y +M+ CW + RP+ ++L L+
Sbjct: 585 GSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI 644
Query: 384 IKTADDEAVLQVPE 397
+ +E L + +
Sbjct: 645 LTLTTNEEYLDLSQ 658
>gi|13186236 fibroblast growth factor receptor 1 isoform 4 precursor
[Homo sapiens]
Length = 731
Score = 162 bits (410), Expect = 5e-40
Identities = 94/309 (30%), Positives = 161/309 (52%), Gaps = 19/309 (6%)
Query: 101 PALAKLQVPREQL--SEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEV 158
P + ++PR++L + L + C G ++ P++ V +K LK A ++
Sbjct: 375 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 434
Query: 159 QDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDG 218
D + ++ + +GKHKN++ L G CT+ PLY+++E ++G+L +L R G
Sbjct: 435 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP-----G 489
Query: 219 LLY----------DLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLC 268
L Y L+ K + QV +E+L K H D+AARN+L+ D K+
Sbjct: 490 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 549
Query: 269 GLGLAYEVYTRGAISSTQT--IPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPP 326
GLA +++ T +P+KW+APE L R + ++DVWSFG+LL+E+ TLG P
Sbjct: 550 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 609
Query: 327 YPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKT 386
YP VP + + L+ M +PS+CT+ +Y +M+ CW + RP+ ++L L+ +
Sbjct: 610 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 669
Query: 387 ADDEAVLQV 395
++ L +
Sbjct: 670 TSNQEYLDL 678
>gi|13186234 fibroblast growth factor receptor 1 isoform 3 precursor
[Homo sapiens]
Length = 733
Score = 162 bits (410), Expect = 5e-40
Identities = 94/309 (30%), Positives = 161/309 (52%), Gaps = 19/309 (6%)
Query: 101 PALAKLQVPREQL--SEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEV 158
P + ++PR++L + L + C G ++ P++ V +K LK A ++
Sbjct: 377 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 436
Query: 159 QDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDG 218
D + ++ + +GKHKN++ L G CT+ PLY+++E ++G+L +L R G
Sbjct: 437 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP-----G 491
Query: 219 LLY----------DLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLC 268
L Y L+ K + QV +E+L K H D+AARN+L+ D K+
Sbjct: 492 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 551
Query: 269 GLGLAYEVYTRGAISSTQT--IPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPP 326
GLA +++ T +P+KW+APE L R + ++DVWSFG+LL+E+ TLG P
Sbjct: 552 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 611
Query: 327 YPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKT 386
YP VP + + L+ M +PS+CT+ +Y +M+ CW + RP+ ++L L+ +
Sbjct: 612 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 671
Query: 387 ADDEAVLQV 395
++ L +
Sbjct: 672 TSNQEYLDL 680
>gi|13186251 fibroblast growth factor receptor 1 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 162 bits (410), Expect = 5e-40
Identities = 94/309 (30%), Positives = 161/309 (52%), Gaps = 19/309 (6%)
Query: 101 PALAKLQVPREQL--SEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEV 158
P + ++PR++L + L + C G ++ P++ V +K LK A ++
Sbjct: 464 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 523
Query: 159 QDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDG 218
D + ++ + +GKHKN++ L G CT+ PLY+++E ++G+L +L R G
Sbjct: 524 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP-----G 578
Query: 219 LLY----------DLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLC 268
L Y L+ K + QV +E+L K H D+AARN+L+ D K+
Sbjct: 579 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 638
Query: 269 GLGLAYEVYTRGAISSTQT--IPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPP 326
GLA +++ T +P+KW+APE L R + ++DVWSFG+LL+E+ TLG P
Sbjct: 639 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 698
Query: 327 YPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKT 386
YP VP + + L+ M +PS+CT+ +Y +M+ CW + RP+ ++L L+ +
Sbjct: 699 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 758
Query: 387 ADDEAVLQV 395
++ L +
Sbjct: 759 TSNQEYLDL 767
>gi|105990522 fibroblast growth factor receptor 1 isoform 1
precursor [Homo sapiens]
Length = 822
Score = 162 bits (410), Expect = 5e-40
Identities = 94/309 (30%), Positives = 161/309 (52%), Gaps = 19/309 (6%)
Query: 101 PALAKLQVPREQL--SEVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEV 158
P + ++PR++L + L + C G ++ P++ V +K LK A ++
Sbjct: 466 PEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDL 525
Query: 159 QDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDG 218
D + ++ + +GKHKN++ L G CT+ PLY+++E ++G+L +L R G
Sbjct: 526 SDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPP-----G 580
Query: 219 LLY----------DLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLC 268
L Y L+ K + QV +E+L K H D+AARN+L+ D K+
Sbjct: 581 LEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIA 640
Query: 269 GLGLAYEVYTRGAISSTQT--IPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPP 326
GLA +++ T +P+KW+APE L R + ++DVWSFG+LL+E+ TLG P
Sbjct: 641 DFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSP 700
Query: 327 YPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKT 386
YP VP + + L+ M +PS+CT+ +Y +M+ CW + RP+ ++L L+ +
Sbjct: 701 YPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVAL 760
Query: 387 ADDEAVLQV 395
++ L +
Sbjct: 761 TSNQEYLDL 769
>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 160 bits (405), Expect = 2e-39
Identities = 115/395 (29%), Positives = 193/395 (48%), Gaps = 30/395 (7%)
Query: 21 EKQYEVIIV---PTLLVTIFLILLGVILWLFIREQRTQQQRSGP----QGIAPVPPPRDL 73
E +Y II+ +L + + L+L G+ R Q + P Q ++ P R
Sbjct: 364 EARYTDIILYASGSLALAVLLLLAGLY-----RGQALHGRHPRPPATVQKLSRFPLARQF 418
Query: 74 SWEAGHGGNVALPL-KETSVENFLGATTPALAKLQVPREQLSE-------VLEQICSGSC 125
S E+G G + L + + + A L L +P + L E + + + G
Sbjct: 419 SLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCF 478
Query: 126 GPIFRANMNTGDPSKP---KSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEG 182
G + RA DP++P +V +K LK+ A ++ D + ++ + +G+HKN++ L G
Sbjct: 479 GQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLG 538
Query: 183 CCTEKLPLYMVLEDVAQGDLLSFLWTCRRDV--MTMDGLLYD---LTEKQVYHIGKQVLL 237
CT++ PLY+++E A+G+L FL R ++ DG L+ + QV
Sbjct: 539 VCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVAR 598
Query: 238 ALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--IPLKWLAP 295
+++L+ + H D+AARN+L+ D K+ GLA V+ T +P+KW+AP
Sbjct: 599 GMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAP 658
Query: 296 ERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTM 355
E L R + ++DVWSFGILL+E+ TLG PYP +P + L+ M RP C +
Sbjct: 659 EALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPEL 718
Query: 356 YSIMKSCWRWREADRPSPRELRLRLEAAIKTADDE 390
Y +M+ CW + RP+ ++L L+ + +E
Sbjct: 719 YGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE 753
>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
[Homo sapiens]
Length = 802
Score = 160 bits (405), Expect = 2e-39
Identities = 115/395 (29%), Positives = 193/395 (48%), Gaps = 30/395 (7%)
Query: 21 EKQYEVIIV---PTLLVTIFLILLGVILWLFIREQRTQQQRSGP----QGIAPVPPPRDL 73
E +Y II+ +L + + L+L G+ R Q + P Q ++ P R
Sbjct: 364 EARYTDIILYASGSLALAVLLLLAGLY-----RGQALHGRHPRPPATVQKLSRFPLARQF 418
Query: 74 SWEAGHGGNVALPL-KETSVENFLGATTPALAKLQVPREQLSE-------VLEQICSGSC 125
S E+G G + L + + + A L L +P + L E + + + G
Sbjct: 419 SLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCF 478
Query: 126 GPIFRANMNTGDPSKP---KSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEG 182
G + RA DP++P +V +K LK+ A ++ D + ++ + +G+HKN++ L G
Sbjct: 479 GQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLG 538
Query: 183 CCTEKLPLYMVLEDVAQGDLLSFLWTCRRDV--MTMDGLLYD---LTEKQVYHIGKQVLL 237
CT++ PLY+++E A+G+L FL R ++ DG L+ + QV
Sbjct: 539 VCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVAR 598
Query: 238 ALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--IPLKWLAP 295
+++L+ + H D+AARN+L+ D K+ GLA V+ T +P+KW+AP
Sbjct: 599 GMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAP 658
Query: 296 ERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTM 355
E L R + ++DVWSFGILL+E+ TLG PYP +P + L+ M RP C +
Sbjct: 659 EALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPEL 718
Query: 356 YSIMKSCWRWREADRPSPRELRLRLEAAIKTADDE 390
Y +M+ CW + RP+ ++L L+ + +E
Sbjct: 719 YGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE 753
>gi|222144237 fibroblast growth factor receptor 2 isoform 6
precursor [Homo sapiens]
Length = 706
Score = 159 bits (402), Expect = 5e-39
Identities = 102/349 (29%), Positives = 176/349 (50%), Gaps = 28/349 (8%)
Query: 73 LSWEAGHGGNVALPLKETSVENFLGATTPALA-----------KLQVPREQLSEVLEQIC 121
+S E+ N PL + A TP LA K + PR++L+ + + +
Sbjct: 315 VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT-LGKPLG 373
Query: 122 SGSCGPIFRANMNTGDPSKPK---SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLV 178
G G + A D KPK +V +K LK+ A ++ D + ++ + +GKHKN++
Sbjct: 374 EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNII 433
Query: 179 QLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDL--------TEKQVYH 230
L G CT+ PLY+++E ++G+L +L R M YD+ T K +
Sbjct: 434 NLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS---YDINRVPEEQMTFKDLVS 490
Query: 231 IGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--I 288
Q+ +E+L + H D+AARN+L+ + K+ GLA ++ T +
Sbjct: 491 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 550
Query: 289 PLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRP 348
P+KW+APE L R + ++DVWSFG+L++E+ TLG PYP +P + + L+ M +P
Sbjct: 551 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 610
Query: 349 SSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPE 397
++CT+ +Y +M+ CW + RP+ ++L L+ + +E L + +
Sbjct: 611 ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQ 659
>gi|222144233 fibroblast growth factor receptor 2 isoform 4
precursor [Homo sapiens]
Length = 709
Score = 159 bits (402), Expect = 5e-39
Identities = 102/349 (29%), Positives = 176/349 (50%), Gaps = 28/349 (8%)
Query: 73 LSWEAGHGGNVALPLKETSVENFLGATTPALA-----------KLQVPREQLSEVLEQIC 121
+S E+ N PL + A TP LA K + PR++L+ + + +
Sbjct: 318 VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT-LGKPLG 376
Query: 122 SGSCGPIFRANMNTGDPSKPK---SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLV 178
G G + A D KPK +V +K LK+ A ++ D + ++ + +GKHKN++
Sbjct: 377 EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNII 436
Query: 179 QLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDL--------TEKQVYH 230
L G CT+ PLY+++E ++G+L +L R M YD+ T K +
Sbjct: 437 NLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS---YDINRVPEEQMTFKDLVS 493
Query: 231 IGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--I 288
Q+ +E+L + H D+AARN+L+ + K+ GLA ++ T +
Sbjct: 494 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 553
Query: 289 PLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRP 348
P+KW+APE L R + ++DVWSFG+L++E+ TLG PYP +P + + L+ M +P
Sbjct: 554 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 613
Query: 349 SSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPE 397
++CT+ +Y +M+ CW + RP+ ++L L+ + +E L + +
Sbjct: 614 ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQ 662
>gi|221316639 fibroblast growth factor receptor 2 isoform 1
precursor [Homo sapiens]
Length = 821
Score = 159 bits (402), Expect = 5e-39
Identities = 102/349 (29%), Positives = 176/349 (50%), Gaps = 28/349 (8%)
Query: 73 LSWEAGHGGNVALPLKETSVENFLGATTPALA-----------KLQVPREQLSEVLEQIC 121
+S E+ N PL + A TP LA K + PR++L+ + + +
Sbjct: 430 VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT-LGKPLG 488
Query: 122 SGSCGPIFRANMNTGDPSKPK---SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLV 178
G G + A D KPK +V +K LK+ A ++ D + ++ + +GKHKN++
Sbjct: 489 EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNII 548
Query: 179 QLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDL--------TEKQVYH 230
L G CT+ PLY+++E ++G+L +L R M YD+ T K +
Sbjct: 549 NLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS---YDINRVPEEQMTFKDLVS 605
Query: 231 IGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--I 288
Q+ +E+L + H D+AARN+L+ + K+ GLA ++ T +
Sbjct: 606 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 665
Query: 289 PLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRP 348
P+KW+APE L R + ++DVWSFG+L++E+ TLG PYP +P + + L+ M +P
Sbjct: 666 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 725
Query: 349 SSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPE 397
++CT+ +Y +M+ CW + RP+ ++L L+ + +E L + +
Sbjct: 726 ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQ 774
>gi|221316638 fibroblast growth factor receptor 2 isoform 2
precursor [Homo sapiens]
Length = 822
Score = 159 bits (402), Expect = 5e-39
Identities = 102/349 (29%), Positives = 176/349 (50%), Gaps = 28/349 (8%)
Query: 73 LSWEAGHGGNVALPLKETSVENFLGATTPALA-----------KLQVPREQLSEVLEQIC 121
+S E+ N PL + A TP LA K + PR++L+ + + +
Sbjct: 431 VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT-LGKPLG 489
Query: 122 SGSCGPIFRANMNTGDPSKPK---SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLV 178
G G + A D KPK +V +K LK+ A ++ D + ++ + +GKHKN++
Sbjct: 490 EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNII 549
Query: 179 QLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDL--------TEKQVYH 230
L G CT+ PLY+++E ++G+L +L R M YD+ T K +
Sbjct: 550 NLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS---YDINRVPEEQMTFKDLVS 606
Query: 231 IGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--I 288
Q+ +E+L + H D+AARN+L+ + K+ GLA ++ T +
Sbjct: 607 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 666
Query: 289 PLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRP 348
P+KW+APE L R + ++DVWSFG+L++E+ TLG PYP +P + + L+ M +P
Sbjct: 667 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 726
Query: 349 SSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDEAVLQVPE 397
++CT+ +Y +M+ CW + RP+ ++L L+ + +E L + +
Sbjct: 727 ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDLSQ 775
>gi|222144244 fibroblast growth factor receptor 2 isoform 9
precursor [Homo sapiens]
Length = 680
Score = 157 bits (398), Expect = 1e-38
Identities = 101/342 (29%), Positives = 173/342 (50%), Gaps = 28/342 (8%)
Query: 73 LSWEAGHGGNVALPLKETSVENFLGATTPALA-----------KLQVPREQLSEVLEQIC 121
+S E+ N PL + A TP LA K + PR++L+ + + +
Sbjct: 342 VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT-LGKPLG 400
Query: 122 SGSCGPIFRANMNTGDPSKPK---SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLV 178
G G + A D KPK +V +K LK+ A ++ D + ++ + +GKHKN++
Sbjct: 401 EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNII 460
Query: 179 QLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDL--------TEKQVYH 230
L G CT+ PLY+++E ++G+L +L R M YD+ T K +
Sbjct: 461 NLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS---YDINRVPEEQMTFKDLVS 517
Query: 231 IGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--I 288
Q+ +E+L + H D+AARN+L+ + K+ GLA ++ T +
Sbjct: 518 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 577
Query: 289 PLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRP 348
P+KW+APE L R + ++DVWSFG+L++E+ TLG PYP +P + + L+ M +P
Sbjct: 578 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 637
Query: 349 SSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDE 390
++CT+ +Y +M+ CW + RP+ ++L L+ + +E
Sbjct: 638 ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 679
>gi|222144231 fibroblast growth factor receptor 2 isoform 3
precursor [Homo sapiens]
Length = 769
Score = 157 bits (398), Expect = 1e-38
Identities = 101/342 (29%), Positives = 173/342 (50%), Gaps = 28/342 (8%)
Query: 73 LSWEAGHGGNVALPLKETSVENFLGATTPALA-----------KLQVPREQLSEVLEQIC 121
+S E+ N PL + A TP LA K + PR++L+ + + +
Sbjct: 431 VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT-LGKPLG 489
Query: 122 SGSCGPIFRANMNTGDPSKPK---SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLV 178
G G + A D KPK +V +K LK+ A ++ D + ++ + +GKHKN++
Sbjct: 490 EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNII 549
Query: 179 QLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDL--------TEKQVYH 230
L G CT+ PLY+++E ++G+L +L R M YD+ T K +
Sbjct: 550 NLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS---YDINRVPEEQMTFKDLVS 606
Query: 231 IGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--I 288
Q+ +E+L + H D+AARN+L+ + K+ GLA ++ T +
Sbjct: 607 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 666
Query: 289 PLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRP 348
P+KW+APE L R + ++DVWSFG+L++E+ TLG PYP +P + + L+ M +P
Sbjct: 667 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 726
Query: 349 SSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDE 390
++CT+ +Y +M+ CW + RP+ ++L L+ + +E
Sbjct: 727 ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 768
>gi|222144235 fibroblast growth factor receptor 2 isoform 5
precursor [Homo sapiens]
Length = 707
Score = 157 bits (398), Expect = 1e-38
Identities = 101/342 (29%), Positives = 173/342 (50%), Gaps = 28/342 (8%)
Query: 73 LSWEAGHGGNVALPLKETSVENFLGATTPALA-----------KLQVPREQLSEVLEQIC 121
+S E+ N PL + A TP LA K + PR++L+ + + +
Sbjct: 341 VSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLT-LGKPLG 399
Query: 122 SGSCGPIFRANMNTGDPSKPK---SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLV 178
G G + A D KPK +V +K LK+ A ++ D + ++ + +GKHKN++
Sbjct: 400 EGCFGQVVMAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNII 459
Query: 179 QLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDL--------TEKQVYH 230
L G CT+ PLY+++E ++G+L +L R M YD+ T K +
Sbjct: 460 NLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS---YDINRVPEEQMTFKDLVS 516
Query: 231 IGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--I 288
Q+ +E+L + H D+AARN+L+ + K+ GLA ++ T +
Sbjct: 517 CTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRL 576
Query: 289 PLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRP 348
P+KW+APE L R + ++DVWSFG+L++E+ TLG PYP +P + + L+ M +P
Sbjct: 577 PVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKP 636
Query: 349 SSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDE 390
++CT+ +Y +M+ CW + RP+ ++L L+ + +E
Sbjct: 637 ANCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNE 678
>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
[Homo sapiens]
Length = 762
Score = 157 bits (396), Expect = 2e-38
Identities = 102/340 (30%), Positives = 170/340 (50%), Gaps = 18/340 (5%)
Query: 69 PPRDLSWEAGHGGNVALPL-KETSVENFLGATTPALAKLQVPREQLSE-------VLEQI 120
P S E+G G + L + + + A L L +P + L E + + +
Sbjct: 374 PTLQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPL 433
Query: 121 CSGSCGPIFRANMNTGDPSKP---KSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNL 177
G G + RA DP++P +V +K LK+ A ++ D + ++ + +G+HKN+
Sbjct: 434 GEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI 493
Query: 178 VQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDV--MTMDGLLYD---LTEKQVYHIG 232
+ L G CT++ PLY+++E A+G+L FL R ++ DG L+ +
Sbjct: 494 INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCA 553
Query: 233 KQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQT--IPL 290
QV +++L+ + H D+AARN+L+ D K+ GLA V+ T +P+
Sbjct: 554 YQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPV 613
Query: 291 KWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSS 350
KW+APE L R + ++DVWSFGILL+E+ TLG PYP +P + L+ M RP
Sbjct: 614 KWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPH 673
Query: 351 CTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTADDE 390
C +Y +M+ CW + RP+ ++L L+ + +E
Sbjct: 674 CPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE 713
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 156 bits (395), Expect = 3e-38
Identities = 89/243 (36%), Positives = 135/243 (55%), Gaps = 19/243 (7%)
Query: 143 SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDL 202
+V +K LKE EV++FL + + KH NLVQL G CT + P Y++ E + G+L
Sbjct: 267 TVAVKTLKEDT--MEVEEFLKEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNL 323
Query: 203 LSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSD 262
L +L C R + LLY T Q+ A+E+L++K+ H D+AARN L+ +
Sbjct: 324 LDYLRECNRQEVNAVVLLYMAT---------QISSAMEYLEKKNFIHRDLAARNCLVGEN 374
Query: 263 LTAKLCGLGLAY----EVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYE 318
K+ GL+ + YT A + P+KW APE L SI++DVW+FG+LL+E
Sbjct: 375 HLVKVADFGLSRLMTGDTYTAHAGAK---FPIKWTAPESLAYNKFSIKSDVWAFGVLLWE 431
Query: 319 MVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRL 378
+ T G PYP + + + E L++ M+RP C +Y +M++CW+W +DRPS E+
Sbjct: 432 IATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 491
Query: 379 RLE 381
E
Sbjct: 492 AFE 494
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 156 bits (395), Expect = 3e-38
Identities = 89/243 (36%), Positives = 135/243 (55%), Gaps = 19/243 (7%)
Query: 143 SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDL 202
+V +K LKE EV++FL + + KH NLVQL G CT + P Y++ E + G+L
Sbjct: 286 TVAVKTLKEDT--MEVEEFLKEAAVMKEI-KHPNLVQLLGVCTREPPFYIITEFMTYGNL 342
Query: 203 LSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSD 262
L +L C R + LLY T Q+ A+E+L++K+ H D+AARN L+ +
Sbjct: 343 LDYLRECNRQEVNAVVLLYMAT---------QISSAMEYLEKKNFIHRDLAARNCLVGEN 393
Query: 263 LTAKLCGLGLAY----EVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYE 318
K+ GL+ + YT A + P+KW APE L SI++DVW+FG+LL+E
Sbjct: 394 HLVKVADFGLSRLMTGDTYTAHAGAK---FPIKWTAPESLAYNKFSIKSDVWAFGVLLWE 450
Query: 319 MVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRL 378
+ T G PYP + + + E L++ M+RP C +Y +M++CW+W +DRPS E+
Sbjct: 451 IATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 510
Query: 379 RLE 381
E
Sbjct: 511 AFE 513
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 155 bits (393), Expect = 5e-38
Identities = 92/255 (36%), Positives = 139/255 (54%), Gaps = 19/255 (7%)
Query: 143 SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDL 202
+V +K LKE EV++FL + + KH NLVQL G CT + P Y+V E + G+L
Sbjct: 292 TVAVKTLKEDT--MEVEEFLKEAAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 348
Query: 203 LSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSD 262
L +L C R+ +T LLY T Q+ A+E+L++K+ H D+AARN L+ +
Sbjct: 349 LDYLRECNREEVTAVVLLYMAT---------QISSAMEYLEKKNFIHRDLAARNCLVGEN 399
Query: 263 LTAKLCGLGLAY----EVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYE 318
K+ GL+ + YT A + P+KW APE L SI++DVW+FG+LL+E
Sbjct: 400 HVVKVADFGLSRLMTGDTYTAHAGAK---FPIKWTAPESLAYNTFSIKSDVWAFGVLLWE 456
Query: 319 MVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRL 378
+ T G PYP + + + + L++ M++P C +Y +M++CW+W ADRPS E
Sbjct: 457 IATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQ 516
Query: 379 RLEAAIKTADDEAVL 393
E + VL
Sbjct: 517 AFETMFHDSSISEVL 531
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 155 bits (391), Expect = 8e-38
Identities = 90/243 (37%), Positives = 136/243 (55%), Gaps = 19/243 (7%)
Query: 143 SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDL 202
+V +K LKE EV++FL + + KH NLVQL G CT + P Y+V E + G+L
Sbjct: 298 TVAVKTLKEDT--MEVEEFLKEAAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 354
Query: 203 LSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSD 262
L +L C R+ +T LLY T Q+ A+E+L++K+ H D+AARN L+ +
Sbjct: 355 LDYLRECNREEVTAVVLLYMAT---------QISSAMEYLEKKNFIHRDLAARNCLVGEN 405
Query: 263 LTAKLCGLGLAY----EVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYE 318
K+ GL+ + YT A + P+KW APE L SI++DVW+FG+LL+E
Sbjct: 406 HVVKVADFGLSRLMTGDTYTAHAGAK---FPIKWTAPESLAYNTFSIKSDVWAFGVLLWE 462
Query: 319 MVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRL 378
+ T G PYP + + + + L++ M++P C +Y +M++CW+W ADRPS E
Sbjct: 463 IATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQ 522
Query: 379 RLE 381
E
Sbjct: 523 AFE 525
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 155 bits (391), Expect = 8e-38
Identities = 90/243 (37%), Positives = 136/243 (55%), Gaps = 19/243 (7%)
Query: 143 SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDL 202
+V +K LKE EV++FL + + KH NLVQL G CT + P Y+V E + G+L
Sbjct: 313 TVAVKTLKEDT--MEVEEFLKEAAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 369
Query: 203 LSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSD 262
L +L C R+ +T LLY T Q+ A+E+L++K+ H D+AARN L+ +
Sbjct: 370 LDYLRECNREEVTAVVLLYMAT---------QISSAMEYLEKKNFIHRDLAARNCLVGEN 420
Query: 263 LTAKLCGLGLAY----EVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYE 318
K+ GL+ + YT A + P+KW APE L SI++DVW+FG+LL+E
Sbjct: 421 HVVKVADFGLSRLMTGDTYTAHAGAK---FPIKWTAPESLAYNTFSIKSDVWAFGVLLWE 477
Query: 319 MVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRL 378
+ T G PYP + + + + L++ M++P C +Y +M++CW+W ADRPS E
Sbjct: 478 IATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQ 537
Query: 379 RLE 381
E
Sbjct: 538 AFE 540
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 155 bits (391), Expect = 8e-38
Identities = 90/243 (37%), Positives = 136/243 (55%), Gaps = 19/243 (7%)
Query: 143 SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDL 202
+V +K LKE EV++FL + + KH NLVQL G CT + P Y+V E + G+L
Sbjct: 298 TVAVKTLKEDT--MEVEEFLKEAAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 354
Query: 203 LSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSD 262
L +L C R+ +T LLY T Q+ A+E+L++K+ H D+AARN L+ +
Sbjct: 355 LDYLRECNREEVTAVVLLYMAT---------QISSAMEYLEKKNFIHRDLAARNCLVGEN 405
Query: 263 LTAKLCGLGLAY----EVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYE 318
K+ GL+ + YT A + P+KW APE L SI++DVW+FG+LL+E
Sbjct: 406 HVVKVADFGLSRLMTGDTYTAHAGAK---FPIKWTAPESLAYNTFSIKSDVWAFGVLLWE 462
Query: 319 MVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRL 378
+ T G PYP + + + + L++ M++P C +Y +M++CW+W ADRPS E
Sbjct: 463 IATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQ 522
Query: 379 RLE 381
E
Sbjct: 523 AFE 525
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 155 bits (391), Expect = 8e-38
Identities = 90/243 (37%), Positives = 136/243 (55%), Gaps = 19/243 (7%)
Query: 143 SVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDL 202
+V +K LKE EV++FL + + KH NLVQL G CT + P Y+V E + G+L
Sbjct: 277 TVAVKTLKEDT--MEVEEFLKEAAVMKEI-KHPNLVQLLGVCTLEPPFYIVTEYMPYGNL 333
Query: 203 LSFLWTCRRDVMTMDGLLYDLTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSD 262
L +L C R+ +T LLY T Q+ A+E+L++K+ H D+AARN L+ +
Sbjct: 334 LDYLRECNREEVTAVVLLYMAT---------QISSAMEYLEKKNFIHRDLAARNCLVGEN 384
Query: 263 LTAKLCGLGLAY----EVYTRGAISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYE 318
K+ GL+ + YT A + P+KW APE L SI++DVW+FG+LL+E
Sbjct: 385 HVVKVADFGLSRLMTGDTYTAHAGAK---FPIKWTAPESLAYNTFSIKSDVWAFGVLLWE 441
Query: 319 MVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREADRPSPRELRL 378
+ T G PYP + + + + L++ M++P C +Y +M++CW+W ADRPS E
Sbjct: 442 IATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQ 501
Query: 379 RLE 381
E
Sbjct: 502 AFE 504
>gi|4885631 tyrosine kinase with immunoglobulin-like and EGF-like
domains 1 [Homo sapiens]
Length = 1138
Score = 142 bits (359), Expect = 4e-34
Identities = 108/378 (28%), Positives = 183/378 (48%), Gaps = 46/378 (12%)
Query: 21 EKQYEVIIVPTLLVTIFLILLGVILWLFIREQRTQQQRSGPQGIAPVPPPRDLSWEAGHG 80
++Q + +V ++ T IL ++ + IR ++R+ ++++G G
Sbjct: 758 DQQLILAVVGSVSATCLTILAALLTLVCIRRSCLHRRRT-------------FTYQSGSG 804
Query: 81 GNVALPLKETSVENFLGATTPALAKLQVPREQLS-EVLEQ--------ICSGSCGPIFRA 131
E ++ F T + ++ E LS VLE I G+ G + RA
Sbjct: 805 --------EETILQFSSGTLTLTRRPKLQPEPLSYPVLEWEDITFEDLIGEGNFGQVIRA 856
Query: 132 NMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLY 191
M D K + I K LKE A ++ +DF G ++ LG H N++ L G C + LY
Sbjct: 857 -MIKKDGLKMNAAI-KMLKEYASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLY 914
Query: 192 MVLEDVAQGDLLSFLWTCRRDVMTMD-------GLLYDLTEKQVYHIGKQVLLALEFLQE 244
+ +E G+LL FL R V+ D G L+ +Q+ +++L E
Sbjct: 915 IAIEYAPYGNLLDFLRKSR--VLETDPAFAREHGTASTLSSRQLLRFASDAANGMQYLSE 972
Query: 245 KHLFHGDVAARNILMQSDLTAKLCGLGLAY--EVYTRGAISSTQTIPLKWLAPERLLLRP 302
K H D+AARN+L+ +L +K+ GL+ EVY + + +P++W+A E L
Sbjct: 973 KQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTMGR---LPVRWMAIESLNYSV 1029
Query: 303 ASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSC 362
+ ++DVWSFG+LL+E+V+LG PY + + E L + M++P +C +Y +M+ C
Sbjct: 1030 YTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQC 1089
Query: 363 WRWREADRPSPRELRLRL 380
WR R +RP ++ L+L
Sbjct: 1090 WRDRPYERPPFAQIALQL 1107
>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
b precursor [Homo sapiens]
Length = 825
Score = 137 bits (344), Expect = 2e-32
Identities = 81/272 (29%), Positives = 145/272 (53%), Gaps = 10/272 (3%)
Query: 119 QICSGSCGPIFRANMNTGDPSKPKSVI-LKALKEPAGLHEVQDFLGRIQFHQYLGKHKNL 177
++ G+ G +F A P+K K ++ +KALK+P L +DF + L +H+++
Sbjct: 543 ELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPT-LAARKDFQREAELLTNL-QHEHI 600
Query: 178 VQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDVMTM-DG----LLYDLTEKQVYHIG 232
V+ G C + PL MV E + GDL FL D M + DG +L Q+ HI
Sbjct: 601 VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA 660
Query: 233 KQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRG--AISSTQTIPL 290
Q+ + +L +H H D+A RN L+ ++L K+ G++ +VY+ + +P+
Sbjct: 661 SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRVGGHTMLPI 720
Query: 291 KWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSS 350
+W+ PE ++ R + +DVWSFG++L+E+ T G P+ ++ T ++E + + ++++RP
Sbjct: 721 RWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRV 780
Query: 351 CTHTMYSIMKSCWRWREADRPSPRELRLRLEA 382
C +Y +M CW+ R + +E+ L A
Sbjct: 781 CPKEVYDVMLGCWQREPQQRLNIKEIYKILHA 812
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 136 bits (342), Expect = 4e-32
Identities = 91/268 (33%), Positives = 135/268 (50%), Gaps = 23/268 (8%)
Query: 115 EVLEQICSGSCGPIFRANMNTGDPSKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKH 174
++L+ I G G + + + V +K +K A Q FL L +H
Sbjct: 196 KLLQTIGKGEFGDVMLGDY------RGNKVAVKCIKNDA---TAQAFLAEASVMTQL-RH 245
Query: 175 KNLVQLEGCCTE-KLPLYMVLEDVAQGDLLSFLWTCRRDVMTMDGLLYDLTEKQVYHIGK 233
NLVQL G E K LY+V E +A+G L+ +L + R V+ D LL
Sbjct: 246 SNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL---------KFSL 296
Query: 234 QVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEVYTRGAISSTQTIPLKWL 293
V A+E+L+ + H D+AARN+L+ D AK+ GL E + T +P+KW
Sbjct: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---SSTQDTGKLPVKWT 353
Query: 294 APERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTH 353
APE L + S ++DVWSFGILL+E+ + G PYP +P ++ +++ M P C
Sbjct: 354 APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPP 413
Query: 354 TMYSIMKSCWRWREADRPSPRELRLRLE 381
+Y +MK+CW A RPS +LR +LE
Sbjct: 414 AVYEVMKNCWHLDAAMRPSFLQLREQLE 441
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,060,221
Number of Sequences: 37866
Number of extensions: 799383
Number of successful extensions: 3950
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 506
Number of HSP's successfully gapped in prelim test: 250
Number of HSP's that attempted gapping in prelim test: 2531
Number of HSP's gapped (non-prelim): 879
length of query: 422
length of database: 18,247,518
effective HSP length: 105
effective length of query: 317
effective length of database: 14,271,588
effective search space: 4524093396
effective search space used: 4524093396
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.