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Search of human proteins with 222080083
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222080083 guanylate cyclase 2C [Homo sapiens]
(1073 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222080083 guanylate cyclase 2C [Homo sapiens] 2175 0.0
gi|167830411 natriuretic peptide receptor 1 [Homo sapiens] 450 e-126
gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens] 426 e-119
gi|134152694 guanylate cyclase 2F [Homo sapiens] 426 e-119
gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Hom... 416 e-116
gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens] 164 3e-40
gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Ho... 158 3e-38
gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 158 3e-38
gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 158 3e-38
gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Hom... 158 3e-38
gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Ho... 158 3e-38
gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Ho... 154 3e-37
gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens] 150 5e-36
gi|31083193 adenylate cyclase 1 [Homo sapiens] 111 3e-24
gi|24497587 adenylate cyclase 4 [Homo sapiens] 110 7e-24
gi|4557257 adenylate cyclase 8 [Homo sapiens] 104 5e-22
gi|4557255 adenylate cyclase 7 [Homo sapiens] 103 9e-22
gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens] 100 7e-21
gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens] 100 7e-21
gi|34486092 adenylate cyclase 5 [Homo sapiens] 100 1e-20
gi|115387102 adenylate cyclase 2 [Homo sapiens] 99 2e-20
gi|148536830 adenylate cyclase 3 [Homo sapiens] 97 6e-20
gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens] 96 2e-19
gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens] 96 2e-19
gi|50959205 adenylate cyclase 9 [Homo sapiens] 94 7e-19
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 91 4e-18
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 91 6e-18
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 91 8e-18
gi|4758280 ephrin receptor EphA4 [Homo sapiens] 88 4e-17
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 88 5e-17
>gi|222080083 guanylate cyclase 2C [Homo sapiens]
Length = 1073
Score = 2175 bits (5635), Expect = 0.0
Identities = 1073/1073 (100%), Positives = 1073/1073 (100%)
Query: 1 MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNE 60
MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNE
Sbjct: 1 MKTLLLDLALWSLLFQPGWLSFSSQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNE 60
Query: 61 GLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLI 120
GLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLI
Sbjct: 61 GLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLI 120
Query: 121 GPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDL 180
GPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDL
Sbjct: 121 GPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDL 180
Query: 181 PFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHN 240
PFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHN
Sbjct: 181 PFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHN 240
Query: 241 RKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLS 300
RKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLS
Sbjct: 241 RKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLS 300
Query: 301 PGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTF 360
PGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTF
Sbjct: 301 PGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTF 360
Query: 361 EGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKL 420
EGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKL
Sbjct: 361 EGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKL 420
Query: 421 PNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLE 480
PNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLE
Sbjct: 421 PNDITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENIFPLE 480
Query: 481 TNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQID 540
TNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQID
Sbjct: 481 TNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVILKDLKHNDGNFTEKQKIELNKLLQID 540
Query: 541 YYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKG 600
YYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKG
Sbjct: 541 YYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKG 600
Query: 601 MSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQK 660
MSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQK
Sbjct: 601 MSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQANISQK 660
Query: 661 GDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEV 720
GDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEV
Sbjct: 661 GDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEV 720
Query: 721 YLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVE 780
YLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVE
Sbjct: 721 YLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVE 780
Query: 781 ERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYS 840
ERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYS
Sbjct: 781 ERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYS 840
Query: 841 TPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEI 900
TPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEI
Sbjct: 841 TPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEI 900
Query: 901 LSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPL 960
LSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPL
Sbjct: 901 LSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPL 960
Query: 961 RIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQ 1020
RIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQ
Sbjct: 961 RIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQ 1020
Query: 1021 RLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF 1073
RLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF
Sbjct: 1021 RLQAEFSDMIANSLQKRQAAGIRSQKPRRVASYKKGTLEYLQLNTTDKESTYF 1073
>gi|167830411 natriuretic peptide receptor 1 [Homo sapiens]
Length = 1061
Score = 450 bits (1157), Expect = e-126
Identities = 334/984 (33%), Positives = 487/984 (49%), Gaps = 141/984 (14%)
Query: 118 VLIGPSCTYSTFQMYLDT-ELSYPMISAGS----FGLSCDYKETLTRLMSPARKLMYFLV 172
V +GP C Y+ + T P+++AG+ FG+ +Y T TR KL F+
Sbjct: 112 VFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALT-TRAGPSYAKLGDFVA 170
Query: 173 NFWKTNDLPFKTYSWSTS----YVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQ 228
+ W Y Y+ G E E CF+ + L V + + +
Sbjct: 171 AL-------HRRLGWERQALMLYAYRPGDE-EHCFFLVEGLFMRVRDRLNITVDHLEFAE 222
Query: 229 D--KEFQDILMDHNRKSNVIIMCGGPE-----FLYKLKGDRAVAEDIVIILVDLFND--- 278
D + +L RK VI +C P+ L L+ ED V +D+F
Sbjct: 223 DDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLC-GEDYVFFHLDIFGQSLQ 281
Query: 279 ----------------------QYFE----------DNVTAPDYMKNVLVLTLSPGNSLL 306
Q F+ DN +++K + L N +
Sbjct: 282 GGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTM 341
Query: 307 NSSFSRNLSPTKRDFALAYLNGI---LLFGHMLKIFLENGENITTPKFAHAFRNLTFEGY 363
+ + D L Y+ + L G + +GENIT + N +F+G
Sbjct: 342 EDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVT----DGENITQRMW-----NRSFQGV 392
Query: 364 DGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPND 423
G + +D GD ++ L + ++V+L Y+ + V W P D
Sbjct: 393 TGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVS-GRKLNWPLGYPPPD 451
Query: 424 ITGRG----------PQILMIAVFTLTGAVVLL--LLVALLMLRKYRKDYELRQK----K 467
I G + + V L G++ LL L+V+ + RK + + EL + +
Sbjct: 452 IPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVR 511
Query: 468 WSHIPPENI----------FPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVI-LK 516
W + P ++ L +N+ SL + + Q + Y K ++ +K
Sbjct: 512 WEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQ----FQVFAKTAYYKGNLVAVK 567
Query: 517 DLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVL-ND 575
+ T K EL + + +LT+F G I + EYC RGSL+++L N+
Sbjct: 568 RVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENE 627
Query: 576 TISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGC 635
+I+ +DW F+ S+ DI KGM +LH+ HG LKS+NCVVD R V+KITD+G
Sbjct: 628 SIT------LDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGL 681
Query: 636 NSI--LPPK-------KDLWTAPEHLRQANI----SQKGDVYSYGIIAQEIILRKETFYT 682
S L P+ K LWTAPE LR A+ SQ GDVYS+GII QEI LR F+
Sbjct: 682 ESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHV 741
Query: 683 ----LSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDF 738
LS ++ E++ R E PFRP L L++ E E+ LL++ CW EDP++RP F
Sbjct: 742 EGLDLSPKEIIERVTRGEQP----PFRPSLALQSHLE---ELGLLMQRCWAEDPQERPPF 794
Query: 739 KKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNF 798
++I TL K F+ + + + +D L+ R++ Y+ NLE LVEERTQ Y E+ +A+ L +
Sbjct: 795 QQIRLTLRK----FNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLY 850
Query: 799 MLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDH 858
+LP V + LK V+ E ++ VTIYFSDIVGFT + STPM+VV +LND+Y FD
Sbjct: 851 QILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDA 910
Query: 859 IVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIW 918
++D+ DVYKVETIGDAYMV SGLP RNG HA ++A+MAL +L + +F + H P +
Sbjct: 911 VIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLR 970
Query: 919 IRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQ 978
+RIG+H+GP AGVVG+KMPRYCLFGDTVNTASRMES G L+IH+S T A+L+
Sbjct: 971 LRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFG-G 1029
Query: 979 FLYEVRGETYLKGRGNETTYWLTG 1002
F E+RG+ +KG+G TYWL G
Sbjct: 1030 FELELRGDVEMKGKGKVRTYWLLG 1053
>gi|4580422 natriuretic peptide receptor B precursor [Homo sapiens]
Length = 1047
Score = 426 bits (1096), Expect = e-119
Identities = 318/972 (32%), Positives = 473/972 (48%), Gaps = 115/972 (11%)
Query: 118 VLIGPSCTYSTFQMY-LDTELSYPMISAGS----FGLSCDYKETLTRLMSPARKLMYFLV 172
+L+GP C Y + + P+++AG+ F D+ TL R A KL F+V
Sbjct: 95 LLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVRTGPSAPKLGEFVV 154
Query: 173 NFWKTNDLPFKTYSWST--SYVYKNG-TETEDCFWYLNALEASVSYFSHELGFKVVLRQD 229
++W+ + +Y + T+ ++ + + ++ + + +V R+
Sbjct: 155 TL-------HGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYAREP 207
Query: 230 KEFQDILMDHNRKSNVIIMCGGPEFLYKL----KGDRAVAEDIVIILVDLFNDQY----- 280
+ ++ +CG E L+++ + + D V +D+F +
Sbjct: 208 GGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPT 267
Query: 281 ------FEDNVTAP------DYMKNVLVLTL-SPGNSLLNSSFSRNLSPTKRDFAL---- 323
++DN T + + VLV+T P N +R L + DF +
Sbjct: 268 RATGRPWQDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGP 327
Query: 324 --------AYLNGILLFGHML-KIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGD 374
+ +GILL+ +L + E G + + + G G V +D D
Sbjct: 328 SLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNND 387
Query: 375 VDSTMVL-LYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPND---------- 423
++ VL +D+ ++ Y + + W P+D
Sbjct: 388 RETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWTGRP--IPWVKGAPPSDNPPCAFDLDD 445
Query: 424 -ITGRGPQILMIAVFTLTGAVVLLLLVA-LLMLRKYRKDYELRQKKWS------------ 469
+ P + V TG ++ V+ L+ RK + EL W
Sbjct: 446 PSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSE 505
Query: 470 --HIPPENIFPLETNETNHVSLKIDDDKRRDTIQRLRQCKYDKKRVI-LKDLKHNDGNFT 526
H + L +++ SL K Q + K V+ +K + T
Sbjct: 506 RYHKGAGSRLTLSLRGSSYGSLMTAHGK----YQIFANTGHFKGNVVAIKHVNKKRIELT 561
Query: 527 EKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVL-NDTISYPDGTFM 585
+ EL + + + +LT+F G I V EYC RGSL+++L ND+I+ +
Sbjct: 562 RQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSIN------L 615
Query: 586 DWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPK--- 642
DW F+ S++ D+ KGM++LH+S HG LKS+NCVVDSR V+KITD+G S
Sbjct: 616 DWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPD 675
Query: 643 -------KDLWTAPEHLRQANIS----QKGDVYSYGIIAQEIILRKETFYTLSCRDRNEK 691
K LWTAPE L + QK DVYS+GII QEI LR FY L D + K
Sbjct: 676 DSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFY-LEGLDLSPK 734
Query: 692 IFRVENSNGMKP-FRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFG 750
+ NG +P FRP + E E+ LL++ CW +DP +RPDF +I+ + +
Sbjct: 735 EIVQKVRNGQRPYFRPSIDRTQLNE---ELVLLMERCWAQDPAERPDFGQIKGFIRR--- 788
Query: 751 LFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLK 810
F+ + S +D L+ R++ Y+ NLE LVEERTQ Y E+ +A+ L + +LP V + LK
Sbjct: 789 -FNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLK 847
Query: 811 EKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVET 870
V+ E ++ VTIYFSDIVGFT + STPM+VV +LND+Y FD I+D+ DVYKVET
Sbjct: 848 RGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVET 907
Query: 871 IGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAA 930
IGDAYMV SGLP RNG RHA +IA+MAL +L + +F + H P + +RIGVH+GP A
Sbjct: 908 IGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCA 967
Query: 931 GVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLK 990
GVVG+KMPRYCLFGDTVNTASRMES G L+IHVS +T L C F E+RG+ +K
Sbjct: 968 GVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGC-FQLELRGDVEMK 1026
Query: 991 GRGNETTYWLTG 1002
G+G TYWL G
Sbjct: 1027 GKGKMRTYWLLG 1038
>gi|134152694 guanylate cyclase 2F [Homo sapiens]
Length = 1108
Score = 426 bits (1094), Expect = e-119
Identities = 249/541 (46%), Positives = 336/541 (62%), Gaps = 53/541 (9%)
Query: 514 ILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVI-EYCERGSLREV 572
++KDL+H + +N LL Y D+ +F ++ E+C RGSL ++
Sbjct: 597 MMKDLRHEN----------INPLLGFFY------------DSGMFAIVTEFCSRGSLEDI 634
Query: 573 LNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITD 632
L + +DW FK S+L D+ KGM YLH + VHGRLKS NCVVD R V+K+TD
Sbjct: 635 LTN-----QDVKLDWMFKSSLLLDLIKGMKYLHHREF-VHGRLKSRNCVVDGRFVLKVTD 688
Query: 633 FGCNSILPP----------KKDLWTAPEHLRQANISQ----KGDVYSYGIIAQEIILRKE 678
+G N IL ++ LWTAPE LR S+ GDVYS+ II QE+++R
Sbjct: 689 YGFNDILEMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGT 748
Query: 679 TFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDF 738
F + E I R++ + +RP + E A + L+ L+K CW E E+RP F
Sbjct: 749 PFCMMDL-PAQEIINRLKKPPPV--YRPVVPPEHAPPECLQ---LMKQCWAEAAEQRPTF 802
Query: 739 KKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNF 798
+I F F+ K + +D+++R L+ YS NLE L+ ERT+ + E+ + ++L
Sbjct: 803 DEIFNQ----FKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLT 858
Query: 799 MLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDH 858
+LP V +SLK+ VEPE ++ VT+YFSDIVGFTTI S P+EVVD+LND+Y FD
Sbjct: 859 QMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDA 918
Query: 859 IVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIW 918
I+ HDVYKVETIGDAYMVASGLPKRNG+RHA +IA M+L+ILS +GTF++ H+P +P+
Sbjct: 919 IIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVR 978
Query: 919 IRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQ 978
IRIG+HSGP AGVVG+ MPRYCLFGDTVNTASRMESTGLP RIHVS ST+ IL+
Sbjct: 979 IRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEG 1038
Query: 979 FLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQ 1038
+ E+RG T LKG+G E T+WL G K LP PP V+ ++ + + Q+R+
Sbjct: 1039 YEVELRGRTELKGKGTEETFWLIGKKGFMKPLPVPPPVDKDGQVGHGLQPVEIAAFQRRK 1098
Query: 1039 A 1039
A
Sbjct: 1099 A 1099
>gi|4504217 guanylate cyclase 2D, membrane (retina-specific) [Homo
sapiens]
Length = 1103
Score = 416 bits (1068), Expect = e-116
Identities = 228/472 (48%), Positives = 304/472 (64%), Gaps = 30/472 (6%)
Query: 560 VIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTN 619
V E+C RGSL+++L +DW FK S+L D+ KG+ YLH + HGRLKS N
Sbjct: 618 VSEHCTRGSLQDLLAQR-----EIKLDWMFKSSLLLDLIKGIRYLHH-RGVAHGRLKSRN 671
Query: 620 CVVDSRMVVKITDFGCNSIL--------PPKKD--LWTAPEHLRQANISQKG----DVYS 665
C+VD R V+KITD G +L PP+ + LWTAPE LR + ++G DV+S
Sbjct: 672 CIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAEDQLWTAPELLRDPALERRGTLAGDVFS 731
Query: 666 YGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVK 725
II QE++ R + L E + RV + + RP L + ++ +E LL+K
Sbjct: 732 LAIIMQEVVCRSAPYAMLELTPE-EVVQRVRSPPPL--CRP---LVSMDQAPVECILLMK 785
Query: 726 NCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQL 785
CW E PE RP +F + + + +D+++R L+ YS NLE L+ ERT+
Sbjct: 786 QCWAEQPELRPSMDHT----FDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEE 841
Query: 786 YKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEV 845
+ E+ + DRL +LP V ++LK VEPE +E+VT+YFSDIVGFTTI S P+EV
Sbjct: 842 LELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEV 901
Query: 846 VDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMG 905
VD+LND+Y FD I+ HDVYKVETIGDAYMVASGLP+RNG RHA +IA M+L+ILS +G
Sbjct: 902 VDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVG 961
Query: 906 TFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVS 965
TF + H+P +P+ IRIG+HSGPC AGVVG+ MPRYCLFGDTVNTASRMESTGLP RIHV+
Sbjct: 962 TFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVN 1021
Query: 966 GSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVE 1017
ST+ IL+ + + E+RG T LKG+G E T+WL G + +P PP ++
Sbjct: 1022 LSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQ 1073
>gi|4504211 guanylate cyclase 1, soluble, alpha 2 [Homo sapiens]
Length = 732
Score = 164 bits (416), Expect = 3e-40
Identities = 93/202 (46%), Positives = 127/202 (62%), Gaps = 3/202 (1%)
Query: 775 LEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFT 834
L+ +E Q + E+ + L + + P V + L + V+ +++VT+ FSDIVGFT
Sbjct: 472 LKATLERTHQALEEEKKKTVDLLYSIFPGDVAQQLWQGQQVQARKFDDVTMLFSDIVGFT 531
Query: 835 TICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIA 894
IC TPM+V+ MLN++Y FDH D+YKVETIGDAY VA+GL R HA IA
Sbjct: 532 AICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVAAGL-HRKSLCHAKPIA 590
Query: 895 KMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954
MAL+++ + E+ G PI +RIG+HSG AGVVG++MPRYCLFG+ V AS+ E
Sbjct: 591 LMALKMMEL--SEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFE 648
Query: 955 STGLPLRIHVSGSTIAILKRTE 976
S P RI+VS +T +LKR E
Sbjct: 649 SGSHPRRINVSPTTYQLLKREE 670
>gi|194595478 guanylate cyclase 1, soluble, alpha 3 isoform B [Homo
sapiens]
Length = 455
Score = 158 bits (399), Expect = 3e-38
Identities = 88/199 (44%), Positives = 123/199 (61%), Gaps = 3/199 (1%)
Query: 775 LEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFT 834
L+ +E+ Q + E+ + L + P V + L + V+ + + VT+ FSDIVGFT
Sbjct: 197 LKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFT 256
Query: 835 TICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIA 894
IC +P++V+ MLN +Y FD DVYKVETIGDAY VA GL K + + HA+ IA
Sbjct: 257 AICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES-DTHAVQIA 315
Query: 895 KMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954
MAL+++ H G PI +RIG+HSG AGVVG+KMPRYCLFG+ V A++ E
Sbjct: 316 LMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFE 373
Query: 955 STGLPLRIHVSGSTIAILK 973
S +P +I+VS +T +LK
Sbjct: 374 SCSVPRKINVSPTTYRLLK 392
>gi|194595476 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 158 bits (399), Expect = 3e-38
Identities = 88/199 (44%), Positives = 123/199 (61%), Gaps = 3/199 (1%)
Query: 775 LEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFT 834
L+ +E+ Q + E+ + L + P V + L + V+ + + VT+ FSDIVGFT
Sbjct: 432 LKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFT 491
Query: 835 TICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIA 894
IC +P++V+ MLN +Y FD DVYKVETIGDAY VA GL K + + HA+ IA
Sbjct: 492 AICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES-DTHAVQIA 550
Query: 895 KMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954
MAL+++ H G PI +RIG+HSG AGVVG+KMPRYCLFG+ V A++ E
Sbjct: 551 LMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFE 608
Query: 955 STGLPLRIHVSGSTIAILK 973
S +P +I+VS +T +LK
Sbjct: 609 SCSVPRKINVSPTTYRLLK 627
>gi|194595472 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 158 bits (399), Expect = 3e-38
Identities = 88/199 (44%), Positives = 123/199 (61%), Gaps = 3/199 (1%)
Query: 775 LEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFT 834
L+ +E+ Q + E+ + L + P V + L + V+ + + VT+ FSDIVGFT
Sbjct: 432 LKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFT 491
Query: 835 TICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIA 894
IC +P++V+ MLN +Y FD DVYKVETIGDAY VA GL K + + HA+ IA
Sbjct: 492 AICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES-DTHAVQIA 550
Query: 895 KMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954
MAL+++ H G PI +RIG+HSG AGVVG+KMPRYCLFG+ V A++ E
Sbjct: 551 LMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFE 608
Query: 955 STGLPLRIHVSGSTIAILK 973
S +P +I+VS +T +LK
Sbjct: 609 SCSVPRKINVSPTTYRLLK 627
>gi|67763816 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 158 bits (399), Expect = 3e-38
Identities = 88/199 (44%), Positives = 123/199 (61%), Gaps = 3/199 (1%)
Query: 775 LEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFT 834
L+ +E+ Q + E+ + L + P V + L + V+ + + VT+ FSDIVGFT
Sbjct: 432 LKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFT 491
Query: 835 TICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIA 894
IC +P++V+ MLN +Y FD DVYKVETIGDAY VA GL K + + HA+ IA
Sbjct: 492 AICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES-DTHAVQIA 550
Query: 895 KMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954
MAL+++ H G PI +RIG+HSG AGVVG+KMPRYCLFG+ V A++ E
Sbjct: 551 LMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFE 608
Query: 955 STGLPLRIHVSGSTIAILK 973
S +P +I+VS +T +LK
Sbjct: 609 SCSVPRKINVSPTTYRLLK 627
>gi|194595474 guanylate cyclase 1, soluble, alpha 3 isoform A [Homo
sapiens]
Length = 690
Score = 158 bits (399), Expect = 3e-38
Identities = 88/199 (44%), Positives = 123/199 (61%), Gaps = 3/199 (1%)
Query: 775 LEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFT 834
L+ +E+ Q + E+ + L + P V + L + V+ + + VT+ FSDIVGFT
Sbjct: 432 LKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFT 491
Query: 835 TICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIA 894
IC +P++V+ MLN +Y FD DVYKVETIGDAY VA GL K + + HA+ IA
Sbjct: 492 AICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES-DTHAVQIA 550
Query: 895 KMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954
MAL+++ H G PI +RIG+HSG AGVVG+KMPRYCLFG+ V A++ E
Sbjct: 551 LMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFE 608
Query: 955 STGLPLRIHVSGSTIAILK 973
S +P +I+VS +T +LK
Sbjct: 609 SCSVPRKINVSPTTYRLLK 627
>gi|194595482 guanylate cyclase 1, soluble, alpha 3 isoform D [Homo
sapiens]
Length = 624
Score = 154 bits (390), Expect = 3e-37
Identities = 86/194 (44%), Positives = 120/194 (61%), Gaps = 3/194 (1%)
Query: 775 LEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFT 834
L+ +E+ Q + E+ + L + P V + L + V+ + + VT+ FSDIVGFT
Sbjct: 432 LKATLEQAHQALEEEKKKTVDLLCSIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFT 491
Query: 835 TICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIA 894
IC +P++V+ MLN +Y FD DVYKVETIGDAY VA GL K + + HA+ IA
Sbjct: 492 AICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHKES-DTHAVQIA 550
Query: 895 KMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRME 954
MAL+++ H G PI +RIG+HSG AGVVG+KMPRYCLFG+ V A++ E
Sbjct: 551 LMALKMMELSDEVMSPH--GEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFE 608
Query: 955 STGLPLRIHVSGST 968
S +P +I+VS +T
Sbjct: 609 SCSVPRKINVSPTT 622
>gi|4504215 guanylate cyclase 1, soluble, beta 3 [Homo sapiens]
Length = 619
Score = 150 bits (380), Expect = 5e-36
Identities = 101/270 (37%), Positives = 145/270 (53%), Gaps = 30/270 (11%)
Query: 751 LFHDQKNESY-----MDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLV 805
L +Q E Y ++ L RLQL R LE E+ + D L + +LP V
Sbjct: 354 LLGEQFREEYKLTQELEILTDRLQLTLRALED-----------EKKKTDTLLYSVLPPSV 402
Query: 806 VKSLKEKGFVEPELYEEVTIYFSDIVGFTTIC-KYST---PMEVVDMLNDIYKSFDHIVD 861
L+ K V + Y+ VTI FS IVGF C K+++ M++V++LND+Y FD + D
Sbjct: 403 ANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTD 462
Query: 862 HHD---VYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIW 918
VYKVET+GD YM SGLP+ + HA I +AL+++ G +++ G +
Sbjct: 463 SRKNPFVYKVETVGDKYMTVSGLPEPCIH-HARSICHLALDMMEIAGQVQVD---GESVQ 518
Query: 919 IRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL---KRT 975
I IG+H+G GV+G +MPRYCLFG+TVN SR E+TG +I+VS T L + +
Sbjct: 519 ITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENS 578
Query: 976 ECQFLYEVRGETYLKGRGNETTYWLTGMKD 1005
+ QF E RG +KG+ W K+
Sbjct: 579 DPQFHLEHRGPVSMKGKKEPMQVWFLSRKN 608
>gi|31083193 adenylate cyclase 1 [Homo sapiens]
Length = 1119
Score = 111 bits (278), Expect = 3e-24
Identities = 76/244 (31%), Positives = 126/244 (51%), Gaps = 23/244 (9%)
Query: 780 EERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELY----EEVTIYFSDIVGFTT 835
EER + K + D R+ F LLP V + +LY +V + F+ I F
Sbjct: 821 EEREDMEKVKLDNR-RILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFND 879
Query: 836 ----ICKYSTPMEVVDMLNDIYKSFDHIVD---HHDVYKVETIGDAYMVASGLPKRNGNR 888
+ + +E + +LN+I FD +++ + D+ K++TIG YM A GL +G +
Sbjct: 880 FYIELDGNNMGVECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTK 939
Query: 889 -------HAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYC 941
H +A A+E+ + E+ + +R+G++ GP AGV+G + P+Y
Sbjct: 940 AKKSISSHLSTLADFAIEMFDVLD--EINYQSYNDFVLRVGINVGPVVAGVIGARRPQYD 997
Query: 942 LFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLT 1001
++G+TVN ASRM+STG+ RI V+ +L+R C + + RG+ +KG+G TY+L
Sbjct: 998 IWGNTVNVASRMDSTGVQGRIQVTEEVHRLLRR--CPYHFVCRGKVSVKGKGEMLTYFLE 1055
Query: 1002 GMKD 1005
G D
Sbjct: 1056 GRTD 1059
Score = 103 bits (257), Expect = 9e-22
Identities = 68/232 (29%), Positives = 125/232 (53%), Gaps = 18/232 (7%)
Query: 779 VEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPEL---------YEEVTIYFSD 829
+E+R +L + E ++ +RL LLPR V +KE PE ++ V+I F+D
Sbjct: 250 IEDRLRL-EDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFAD 308
Query: 830 IVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGL--PKRNGN 887
IVGFT + T E+V +LN+++ FD + + +++ +GD Y SGL PK +
Sbjct: 309 IVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTD-- 366
Query: 888 RHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTV 947
HA +M L+++ + + + + + +R+G+H+G GV+G++ +Y ++ + V
Sbjct: 367 -HAHCCVEMGLDMIDTITS--VAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDV 423
Query: 948 NTASRMESTGLPLRIHVSGSTIAILKRT-ECQFLYEVRGETYLKGRGNETTY 998
A+ ME+ GLP ++H++ +T+A L E + Y ++LK ET +
Sbjct: 424 TLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFF 475
>gi|24497587 adenylate cyclase 4 [Homo sapiens]
Length = 1077
Score = 110 bits (275), Expect = 7e-24
Identities = 66/213 (30%), Positives = 118/213 (55%), Gaps = 14/213 (6%)
Query: 766 RRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVV------KSLKEKGFVEPEL 819
RRL ++ EHL+ Y A +A+ ++ RL +S + +
Sbjct: 214 RRLDTEKKHQEHLLLSILPAYLAREMKAE-----IMARLQAGQGSRPESTNNFHSLYVKR 268
Query: 820 YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879
++ V++ ++DIVGFT + +P E+V MLN+++ FD I H+ +++ +GD Y S
Sbjct: 269 HQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVS 328
Query: 880 GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939
GLP + HAI+ +M L++ + +L G+ I +R+GVHSG GV+G++ +
Sbjct: 329 GLPLSLPD-HAINCVRMGLDMCRAIR--KLRAATGVDINMRVGVHSGSVLCGVIGLQKWQ 385
Query: 940 YCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL 972
Y ++ V A+ ME+ G+P R+H++G+T+A+L
Sbjct: 386 YDVWSHDVTLANHMEAGGVPGRVHITGATLALL 418
Score = 85.5 bits (210), Expect = 2e-16
Identities = 74/262 (28%), Positives = 127/262 (48%), Gaps = 30/262 (11%)
Query: 764 LIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLL---------PRLVVKSLKEKGF 814
L R+ + Y R L+ L +++ + + E + + L +LL P+ + ++ + +
Sbjct: 806 LARQNEYYCR-LDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDL 864
Query: 815 VEPELYEEVTIYFSDIVGFTTICKYST----PMEVVDMLNDIYKSFDHIVDH---HDVYK 867
+ YE V + F+ + F S +E + +LN+I FD ++ V K
Sbjct: 865 YH-QSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEK 923
Query: 868 VETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIW--------- 918
++TIG YM A+GL +G D A+ + L M F + L +
Sbjct: 924 IKTIGSTYMAATGLNATSGQDAQQD-AERSCSHLGTMVEFAVALGSKLDVINKHSFNNFR 982
Query: 919 IRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQ 978
+R+G++ GP AGV+G + P+Y ++G+TVN ASRMESTG+ +I V+ T L+
Sbjct: 983 LRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQ--SLG 1040
Query: 979 FLYEVRGETYLKGRGNETTYWL 1000
+ RG +KG+G TY+L
Sbjct: 1041 YTCYSRGVIKVKGKGQLCTYFL 1062
>gi|4557257 adenylate cyclase 8 [Homo sapiens]
Length = 1251
Score = 104 bits (259), Expect = 5e-22
Identities = 97/332 (29%), Positives = 144/332 (43%), Gaps = 39/332 (11%)
Query: 771 YSRNLEHL----VEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEE---- 822
Y+ L+ L +E K R+ + + +LP V + EK ELY +
Sbjct: 921 YTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDA 980
Query: 823 VTIYFSDIVGFTTICKYSTP----MEVVDMLNDIYKSFDHIVDH---HDVYKVETIGDAY 875
V + F+ I GF + +E + +LN+I FD ++ D+ K++TIG Y
Sbjct: 981 VGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIKTIGSTY 1040
Query: 876 MVASGLPKRNGN-----RHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAA 930
M SGL H +A +L + + + RIG+ G A
Sbjct: 1041 MAVSGLSPEKQQCEDKWGHLCALADFSLALTESIQEINKHSFNNFEL--RIGISHGSVVA 1098
Query: 931 GVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLK 990
GV+G K P+Y ++G TVN ASRM+STG+ RI V T ILK + F ++ RGE Y+K
Sbjct: 1099 GVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILK--DQGFAFDYRGEIYVK 1156
Query: 991 G----RGNETTYWLTG-MKDQKFNLPTPPTVENQQRLQAEFSDMIANSLQKRQ------- 1038
G G TY+L G ++ F LP P + Q L A ++ + ++RQ
Sbjct: 1157 GISEQEGKIKTYFLLGRVQPNPFILP-PRRLPGQYSLAAVVLGLVQSLNRQRQKQLLNEN 1215
Query: 1039 --AAGIRSQKPRRVASYKKGTLEYLQLNTTDK 1068
I+ RR GT Q TDK
Sbjct: 1216 NNTGIIKGHYNRRTLLSPSGTEPGAQAEGTDK 1247
Score = 99.8 bits (247), Expect = 1e-20
Identities = 71/234 (30%), Positives = 120/234 (51%), Gaps = 27/234 (11%)
Query: 779 VEERTQLYKAERDRADRLNFMLLPRLVV-KSLKEKGFVEPE------------LYEEVTI 825
VE R +L + E R +RL +LPR VV + + + VE E YE V+I
Sbjct: 357 VEARLRL-ETENQRQERLVLSVLPRFVVLEMINDMTNVEDEHLQHQFHRIYIHRYENVSI 415
Query: 826 YFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRN 885
F+D+ GFT + + E+V MLN+++ FD + H +++ +GD Y SGLP+
Sbjct: 416 LFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPR 475
Query: 886 GNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGD 945
+ HA +M L ++ + + + +RIG+HSG GV+G++ ++ ++
Sbjct: 476 QD-HAHCCVEMGLSMIKTIR--YVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSW 532
Query: 946 TVNTASRMESTGLPLRIHVSGSTIAILK----------RTECQFLYEVRGETYL 989
V+ A+++ES G+P RIH+S +T+ L + +FL + ETYL
Sbjct: 533 DVDIANKLESGGIPGRIHISKATLDCLNGDYNVEEGHGKERNEFLRKHNIETYL 586
>gi|4557255 adenylate cyclase 7 [Homo sapiens]
Length = 1080
Score = 103 bits (257), Expect = 9e-22
Identities = 62/197 (31%), Positives = 114/197 (57%), Gaps = 8/197 (4%)
Query: 820 YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879
++ V+I ++DIVGFT + +P E+V +LN+++ FD I ++ +++ +GD Y S
Sbjct: 275 HQNVSILYADIVGFTQLASDCSPKELVVVLNELFGKFDQIAKANECMRIKILGDCYYCVS 334
Query: 880 GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939
GLP + HA + KM L++ + ++ G+ I +R+G+HSG GV+G++ +
Sbjct: 335 GLPV-SLPTHARNCVKMGLDMCQAIK--QVREATGVDINMRVGIHSGNVLCGVIGLRKWQ 391
Query: 940 YCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL-KRTECQFLYEVRGETYLKGRGNETTY 998
Y ++ V+ A+RME+ G+P R+H++ +T+ L K E + + + + YLK N TY
Sbjct: 392 YDVWSHDVSLANRMEAAGVPGRVHITEATLKHLDKAYEVEDGHGQQRDPYLK-EMNIRTY 450
Query: 999 WLTGMKDQKFNLPTPPT 1015
+ + Q+ P PP+
Sbjct: 451 LVIDPRSQQ---PPPPS 464
Score = 87.4 bits (215), Expect = 6e-17
Identities = 73/260 (28%), Positives = 131/260 (50%), Gaps = 26/260 (10%)
Query: 763 TLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEE 822
TL R++ Y R L+ L +++ + E + + +N +LL ++ + F+ +L E+
Sbjct: 812 TLSRQIDYYCR-LDCLWKKKFKKEHEEFETMENVNRLLLENVLPAHVAAH-FIGDKLNED 869
Query: 823 --------VTIYFSDIVGFT---TICKYSTP-MEVVDMLNDIYKSFDHIV---DHHDVYK 867
V + F+ + F T C + +E + +LN+I FD ++ V K
Sbjct: 870 WYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLRLLNEIIADFDELLLKPKFSGVEK 929
Query: 868 VETIGDAYMVASGLPKRNGNRHA-IDIAKMALEILSFMGTFELEHLPGL------PIWIR 920
++TIG YM A+GL +G+ + ++ + ++ + L G+ +R
Sbjct: 930 IKTIGSTYMAAAGLSVASGHENQELERQHAHIGVMVEFSIALMSKLDGINRHSFNSFRLR 989
Query: 921 IGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFL 980
+G++ GP AGV+G + P+Y ++G+TVN ASRMESTG +I V+ T IL+ +
Sbjct: 990 VGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTGELGKIQVTEETCTILQ--GLGYS 1047
Query: 981 YEVRGETYLKGRGNETTYWL 1000
E RG +KG+G TY++
Sbjct: 1048 CECRGLINVKGKGELRTYFV 1067
>gi|10181096 adenylate cyclase 6 isoform a [Homo sapiens]
Length = 1168
Score = 100 bits (249), Expect = 7e-21
Identities = 72/223 (32%), Positives = 109/223 (48%), Gaps = 19/223 (8%)
Query: 795 RLNFMLLPRLVVKSLKEKGFVEPELY----EEVTIYFSDIVGFTTIC----KYSTPMEVV 846
RL +LP+ V + ELY E V + F+ I F+ + +E +
Sbjct: 946 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 1005
Query: 847 DMLNDIYKSFDHIVDHH---DVYKVETIGDAYMVASGLPKRN----GNRHAIDIAKMALE 899
+LN+I FD I+ + K++TIG YM ASGL G H +A A+
Sbjct: 1006 RLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMR 1065
Query: 900 ILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLP 959
++ M + +IG++ GP AGV+G + P+Y ++G+TVN +SRM+STG+P
Sbjct: 1066 LMEQMKHINEHSFNNFQM--KIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVP 1123
Query: 960 LRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG 1002
RI V+ +L Q E RG +KG+G TTY+L G
Sbjct: 1124 DRIQVTTDLYQVLAAKGYQL--ECRGVVKVKGKGEMTTYFLNG 1164
Score = 94.7 bits (234), Expect = 4e-19
Identities = 75/293 (25%), Positives = 138/293 (47%), Gaps = 34/293 (11%)
Query: 789 ERDRADRLNFMLLPRLVVKSLKEKGFVEPE----------LYEEVTIYFSDIVGFTTICK 838
E + +RL +LP+ V +KE + E ++ V+I F+DI GFT++
Sbjct: 334 ENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 393
Query: 839 YSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMAL 898
T E+V LN+++ FD + + +++ +GD Y SGLP+ + HA +M +
Sbjct: 394 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGV 452
Query: 899 EILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGL 958
+++ + + + G+ + +R+G+HSG GV+G++ ++ ++ + V A+ ME+ G
Sbjct: 453 DMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGR 510
Query: 959 PLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVEN 1018
RIH++ +T+ L YEV GRG E +L + F +
Sbjct: 511 AGRIHITRATLQYLNGD-----YEVE-----PGRGGERNAYLKEQHIETF------LILG 554
Query: 1019 QQRLQAEFSDMIANSLQKRQAAGIRSQKPR----RVASYKKGTLEYLQLNTTD 1067
+ + E M+A LQ+ +A + PR R S K + + Q+ D
Sbjct: 555 ASQKRKEEKAMLA-KLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDD 606
>gi|10947061 adenylate cyclase 6 isoform b [Homo sapiens]
Length = 1115
Score = 100 bits (249), Expect = 7e-21
Identities = 72/223 (32%), Positives = 109/223 (48%), Gaps = 19/223 (8%)
Query: 795 RLNFMLLPRLVVKSLKEKGFVEPELY----EEVTIYFSDIVGFTTIC----KYSTPMEVV 846
RL +LP+ V + ELY E V + F+ I F+ + +E +
Sbjct: 893 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 952
Query: 847 DMLNDIYKSFDHIVDHH---DVYKVETIGDAYMVASGLPKRN----GNRHAIDIAKMALE 899
+LN+I FD I+ + K++TIG YM ASGL G H +A A+
Sbjct: 953 RLLNEIIADFDEIISEERFRQLEKIKTIGSTYMAASGLNASTYDQVGRSHITALADYAMR 1012
Query: 900 ILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLP 959
++ M + +IG++ GP AGV+G + P+Y ++G+TVN +SRM+STG+P
Sbjct: 1013 LMEQMKHINEHSFNNFQM--KIGLNMGPVVAGVIGARKPQYDIWGNTVNVSSRMDSTGVP 1070
Query: 960 LRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG 1002
RI V+ +L Q E RG +KG+G TTY+L G
Sbjct: 1071 DRIQVTTDLYQVLAAKGYQL--ECRGVVKVKGKGEMTTYFLNG 1111
Score = 94.7 bits (234), Expect = 4e-19
Identities = 75/293 (25%), Positives = 138/293 (47%), Gaps = 34/293 (11%)
Query: 789 ERDRADRLNFMLLPRLVVKSLKEKGFVEPE----------LYEEVTIYFSDIVGFTTICK 838
E + +RL +LP+ V +KE + E ++ V+I F+DI GFT++
Sbjct: 334 ENRQQERLLLSVLPQHVAMEMKEDINTKKEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 393
Query: 839 YSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMAL 898
T E+V LN+++ FD + + +++ +GD Y SGLP+ + HA +M +
Sbjct: 394 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGV 452
Query: 899 EILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGL 958
+++ + + + G+ + +R+G+HSG GV+G++ ++ ++ + V A+ ME+ G
Sbjct: 453 DMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGR 510
Query: 959 PLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTVEN 1018
RIH++ +T+ L YEV GRG E +L + F +
Sbjct: 511 AGRIHITRATLQYLNGD-----YEVE-----PGRGGERNAYLKEQHIETF------LILG 554
Query: 1019 QQRLQAEFSDMIANSLQKRQAAGIRSQKPR----RVASYKKGTLEYLQLNTTD 1067
+ + E M+A LQ+ +A + PR R S K + + Q+ D
Sbjct: 555 ASQKRKEEKAMLA-KLQRTRANSMEGLMPRWVPDRAFSRTKDSKAFRQMGIDD 606
>gi|34486092 adenylate cyclase 5 [Homo sapiens]
Length = 1261
Score = 99.8 bits (247), Expect = 1e-20
Identities = 72/223 (32%), Positives = 109/223 (48%), Gaps = 19/223 (8%)
Query: 795 RLNFMLLPRLVVKSLKEKGFVEPELY----EEVTIYFSDIVGFTTIC----KYSTPMEVV 846
RL +LP+ V + ELY E V + F+ I F+ + +E +
Sbjct: 1038 RLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIANFSEFYVELEANNEGVECL 1097
Query: 847 DMLNDIYKSFDHIVDH---HDVYKVETIGDAYMVASGLPKRN----GNRHAIDIAKMALE 899
+LN+I FD I+ + K++TIG YM ASGL G H +A A++
Sbjct: 1098 RLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDSTYDKVGKTHIKALADFAMK 1157
Query: 900 ILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLP 959
++ M + +IG++ GP AGV+G + P+Y ++G+TVN ASRM+STG+P
Sbjct: 1158 LMDQMKYINEHSFNNFQM--KIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVP 1215
Query: 960 LRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG 1002
RI V+ +L Q E RG +KG+G TY+L G
Sbjct: 1216 DRIQVTTDMYQVLAANTYQL--ECRGVVKVKGKGEMMTYFLNG 1256
Score = 91.7 bits (226), Expect = 3e-18
Identities = 63/224 (28%), Positives = 116/224 (51%), Gaps = 24/224 (10%)
Query: 789 ERDRADRLNFMLLPRLVVKSLK------EKGFVEPELY----EEVTIYFSDIVGFTTICK 838
E + +RL +LPR V +K ++ + ++Y + V+I F+DI GFT++
Sbjct: 424 ENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFTSLAS 483
Query: 839 YSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMAL 898
T E+V LN+++ FD + + +++ +GD Y SGLP+ + HA +M +
Sbjct: 484 QCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARAD-HAHCCVEMGM 542
Query: 899 EILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGL 958
+++ + + + G+ + +R+G+HSG GV+G++ ++ ++ + V A+ ME+ G
Sbjct: 543 DMIEAISL--VREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGGK 600
Query: 959 PLRIHVSGSTIAILKRTECQFLYEVR----GE--TYLKGRGNET 996
RIH++ +T+ L YEV GE YLK ET
Sbjct: 601 AGRIHITKATLNYLNGD-----YEVEPGCGGERNAYLKEHSIET 639
>gi|115387102 adenylate cyclase 2 [Homo sapiens]
Length = 1091
Score = 99.0 bits (245), Expect = 2e-20
Identities = 52/150 (34%), Positives = 89/150 (59%), Gaps = 3/150 (2%)
Query: 820 YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879
+ V+I ++DIVGFT + +P E+V MLN+++ FD I ++ +++ +GD Y S
Sbjct: 286 HTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVS 345
Query: 880 GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939
GLP N HA + KM L++ + ++ G+ I +R+GVHSG GV+G++ +
Sbjct: 346 GLPISLPN-HAKNCVKMGLDMCEAIK--KVRDATGVDINMRVGVHSGNVLCGVIGLQKWQ 402
Query: 940 YCLFGDTVNTASRMESTGLPLRIHVSGSTI 969
Y ++ V A+ ME+ G+P R+H+S T+
Sbjct: 403 YDVWSHDVTLANHMEAGGVPGRVHISSVTL 432
Score = 86.7 bits (213), Expect = 1e-16
Identities = 71/258 (27%), Positives = 126/258 (48%), Gaps = 26/258 (10%)
Query: 766 RRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLL----PRLVVKSLKEKGFVEPELYE 821
R+ + Y R L+ L + + + + E + + LN +LL P V + + ELY
Sbjct: 822 RQNEYYCR-LDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYH 880
Query: 822 E----VTIYFSDIVGFTTICKYSTP----MEVVDMLNDIYKSFDHIVDH---HDVYKVET 870
+ V + F+ I F S +E + +LN+I FD ++ V K++T
Sbjct: 881 QSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKT 940
Query: 871 IGDAYMVASGLPKRNGNRHAIDIAKMALEI-------LSFMGTFELEHLPGLPIW-IRIG 922
IG YM A+GL H+ + + + I + +G + + + +R+G
Sbjct: 941 IGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVG 1000
Query: 923 VHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYE 982
++ GP AGV+G + P+Y ++G+TVN ASRM+STG+ +I V+ T +L+ +
Sbjct: 1001 INHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQ--TLGYTCT 1058
Query: 983 VRGETYLKGRGNETTYWL 1000
RG +KG+G+ TY++
Sbjct: 1059 CRGIINVKGKGDLKTYFV 1076
>gi|148536830 adenylate cyclase 3 [Homo sapiens]
Length = 1144
Score = 97.4 bits (241), Expect = 6e-20
Identities = 80/284 (28%), Positives = 136/284 (47%), Gaps = 35/284 (12%)
Query: 760 YMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFML---LPRLVVKSLKEKGFVE 816
+++ L R L L+ + +++ ++Y+ R + ML + R + S K +
Sbjct: 859 HVEKLARTLFLWKIEVH---DQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELY 915
Query: 817 PELYEEVTIYFSDIVGFTTICKYST----PMEVVDMLNDIYKSFDHIVDHHD---VYKVE 869
+ Y+E+ + F+ + F + +E + LN+I FD ++D+ + K++
Sbjct: 916 SQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIK 975
Query: 870 TIGDAYMVASGL-PKRNGN----------------RHAIDIAKMALEILSFMGTFELEHL 912
TIG YM ASG+ P N N +H D+A AL + + +
Sbjct: 976 TIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSF 1035
Query: 913 PGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAIL 972
+RIG++ G AGV+G + P Y ++G+TVN ASRMESTG+ I V T IL
Sbjct: 1036 NNF--MLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVIL 1093
Query: 973 KRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQKFNLPTPPTV 1016
+ E F + RG ++KG+G T++L G +D+ P P+V
Sbjct: 1094 R--EYGFRFVRRGPIFVKGKGELLTFFLKG-RDKLATFPNGPSV 1134
Score = 94.7 bits (234), Expect = 4e-19
Identities = 57/180 (31%), Positives = 96/180 (53%), Gaps = 13/180 (7%)
Query: 820 YEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVAS 879
+E V+I F+DIVGFT + + E+V +LN+++ FD + + +++ +GD Y
Sbjct: 315 HENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCIC 374
Query: 880 GLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPR 939
GLP + HA+ M L ++ + + G+ +R+GVH+G GV+G K +
Sbjct: 375 GLPDYRED-HAVCSILMGLAMVEAISYVREKTKTGVD--MRVGVHTGTVLGGVLGQKRWQ 431
Query: 940 YCLFGDTVNTASRMESTGLPLRIHVSGSTIAILK----------RTECQFLYEVRGETYL 989
Y ++ V A++ME+ G+P R+H+S ST+ LK + C +L E ETYL
Sbjct: 432 YDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYL 491
>gi|4502435 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 95.9 bits (237), Expect = 2e-19
Identities = 66/249 (26%), Positives = 122/249 (48%), Gaps = 31/249 (12%)
Query: 507 KYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCER 566
+YD ++K+ ++ F + E ++++ + L KFYG + I+ V EY
Sbjct: 439 QYDVAVKMIKEGSMSEDEFFQ----EAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISN 494
Query: 567 GSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRM 626
G L L G ++ + + YD+ +GM++L S + +H L + NC+VD +
Sbjct: 495 GCLLNYLRS-----HGKGLEPSQLLEMCYDVCEGMAFLESHQF-IHRDLAARNCLVDRDL 548
Query: 627 VVKITDFGCNSILPPKKDL----------WTAPEHLRQANISQKGDVYSYGIIAQEIILR 676
VK++DFG + + + W+APE S K DV+++GI+ E+
Sbjct: 549 CVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSL 608
Query: 677 KETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRP 736
+ Y L D ++ + +V S G + +RP L +T +Y ++ +CW E PEKRP
Sbjct: 609 GKQPYDLY--DNSQVVLKV--SQGHRLYRPHLASDT-------IYQIMYSCWHELPEKRP 657
Query: 737 DFKKIETTL 745
F+++ +++
Sbjct: 658 TFQQLLSSI 666
>gi|42544182 BMX non-receptor tyrosine kinase [Homo sapiens]
Length = 675
Score = 95.9 bits (237), Expect = 2e-19
Identities = 66/249 (26%), Positives = 122/249 (48%), Gaps = 31/249 (12%)
Query: 507 KYDKKRVILKDLKHNDGNFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCER 566
+YD ++K+ ++ F + E ++++ + L KFYG + I+ V EY
Sbjct: 439 QYDVAVKMIKEGSMSEDEFFQ----EAQTMMKLSHPKLVKFYGVCSKEYPIYIVTEYISN 494
Query: 567 GSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRM 626
G L L G ++ + + YD+ +GM++L S + +H L + NC+VD +
Sbjct: 495 GCLLNYLRS-----HGKGLEPSQLLEMCYDVCEGMAFLESHQF-IHRDLAARNCLVDRDL 548
Query: 627 VVKITDFGCNSILPPKKDL----------WTAPEHLRQANISQKGDVYSYGIIAQEIILR 676
VK++DFG + + + W+APE S K DV+++GI+ E+
Sbjct: 549 CVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSL 608
Query: 677 KETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRP 736
+ Y L D ++ + +V S G + +RP L +T +Y ++ +CW E PEKRP
Sbjct: 609 GKQPYDLY--DNSQVVLKV--SQGHRLYRPHLASDT-------IYQIMYSCWHELPEKRP 657
Query: 737 DFKKIETTL 745
F+++ +++
Sbjct: 658 TFQQLLSSI 666
>gi|50959205 adenylate cyclase 9 [Homo sapiens]
Length = 1353
Score = 94.0 bits (232), Expect = 7e-19
Identities = 70/228 (30%), Positives = 114/228 (50%), Gaps = 16/228 (7%)
Query: 782 RTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICK--Y 839
RT++ ++ RD+AD L ++P V + LK ++ + F+ IV F+ + Y
Sbjct: 1018 RTKI-QSMRDQADWLLRNIIPYHVAEQLKVSQTYSKN-HDSGGVIFASIVNFSEFYEENY 1075
Query: 840 STPMEVVDMLNDIYKSFDHIV---DHHDVYKVETIGDAYMVASGLPKRNGN------RHA 890
E +LN++ FD ++ D+ + K++TIG YM ASGL H
Sbjct: 1076 EGGKECYRVLNELIGDFDELLSKPDYSSIEKIKTIGATYMAASGLNTAQAQDGSHPQEHL 1135
Query: 891 IDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTA 950
+ + A E++ + F ++ +R+G + GP AGV+G Y ++GDTVN A
Sbjct: 1136 QILFEFAKEMMRVVDDFN-NNMLWFNFKLRVGFNHGPLTAGVIGTTKLLYDIWGDTVNIA 1194
Query: 951 SRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTY 998
SRM++TG+ RI VS + +L + F Y RG +KG+G TY
Sbjct: 1195 SRMDTTGVECRIQVSEESYRVLSKMGYDFDY--RGTVNVKGKGQMKTY 1240
Score = 85.5 bits (210), Expect = 2e-16
Identities = 47/152 (30%), Positives = 85/152 (55%), Gaps = 3/152 (1%)
Query: 821 EEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASG 880
EEV+I F+DIVGFT + + +V +LND++ FD + + K+ T+GD Y +G
Sbjct: 391 EEVSILFADIVGFTKMSANKSAHALVGLLNDLFGRFDRLCEETKCEKISTLGDCYYCVAG 450
Query: 881 LPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRY 940
P+ + HA +M L ++ + F E + +R+GVH+G G++G++ ++
Sbjct: 451 CPEPRAD-HAYCCIEMGLGMIKAIEQFCQEKKE--MVNMRVGVHTGTVLCGILGMRRFKF 507
Query: 941 CLFGDTVNTASRMESTGLPLRIHVSGSTIAIL 972
++ + VN A+ ME G+ ++H+S +T L
Sbjct: 508 DVWSNDVNLANLMEQLGVAGKVHISEATAKYL 539
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 91.3 bits (225), Expect = 4e-18
Identities = 68/252 (26%), Positives = 115/252 (45%), Gaps = 36/252 (14%)
Query: 513 VILKDLKHNDGNFTEKQKI----ELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGS 568
V +K LK +TEKQ++ E + Q ++N+ + G + + + EY E G+
Sbjct: 643 VAIKTLK---AGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGA 699
Query: 569 LREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVV 628
L + L + DG F + + +L IA GM YL ++ VH L + N +V+S +V
Sbjct: 700 LDKFLREK----DGEFSVLQL-VGMLRGIAAGMKYL-ANMNYVHRDLAARNILVNSNLVC 753
Query: 629 KITDFGCNSILPPKKDL------------WTAPEHLRQANISQKGDVYSYGIIAQEIILR 676
K++DFG + +L + WTAPE + + DV+S+GI+ E++
Sbjct: 754 KVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPEAISYRKFTSASDVWSFGIVMWEVMTY 813
Query: 677 KETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRP 736
E Y + + N MK L T + +Y L+ CW+++ +RP
Sbjct: 814 GERPY-----------WELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRP 862
Query: 737 DFKKIETTLAKI 748
F I + L K+
Sbjct: 863 KFADIVSILDKL 874
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 90.9 bits (224), Expect = 6e-18
Identities = 85/321 (26%), Positives = 141/321 (43%), Gaps = 51/321 (15%)
Query: 526 TEKQKIELNKLLQID----------YYNLTKFYGTVKLDTMIFGVI-EYCERGSLREVLN 574
++ +++ + KLL+I+ + N+ +FYG + L+ +G++ EY GSL + +N
Sbjct: 37 SQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVI-LEPPNYGIVTEYASLGSLYDYIN 95
Query: 575 DTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTE--VHGRLKSTNCVVDSRMVVKITD 632
S MD + ++ D+AKGM YLH +H LKS N V+ + V+KI D
Sbjct: 96 SNRSEE----MDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICD 151
Query: 633 FGCNSILPPKKDL-------WTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSC 685
FG + + W APE ++ +S+ D YSYG++ E++ R+ F L
Sbjct: 152 FGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG 211
Query: 686 RDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKI---- 741
+ + P F E L+ CWE D +KRP FK+I
Sbjct: 212 LQVAWLVVEKNERLTIPSSCPRSFAE-----------LLHQCWEADAKKRPSFKQIISIL 260
Query: 742 -----ETTLAKIFGLFHDQKNE--SYMDTLIRRLQLYSRNL----EHLVEERTQLYKAER 790
+T+L F K E ++ + RL+ R+L + L E +L E+
Sbjct: 261 ESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQ 320
Query: 791 DRADRLNFMLLPRLVVKSLKE 811
++ N LLP + + E
Sbjct: 321 KLTEQSNTPLLPSFEIGAWTE 341
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 90.5 bits (223), Expect = 8e-18
Identities = 86/324 (26%), Positives = 142/324 (43%), Gaps = 51/324 (15%)
Query: 526 TEKQKIELNKLLQID----------YYNLTKFYGTVKLDTMIFGVI-EYCERGSLREVLN 574
++ +++ + KLL+I+ + N+ +FYG + L+ +G++ EY GSL + +N
Sbjct: 37 SQDKEVAVKKLLKIEKEAEILSVLSHRNIIQFYGVI-LEPPNYGIVTEYASLGSLYDYIN 95
Query: 575 DTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTE--VHGRLKSTNCVVDSRMVVKITD 632
S MD + ++ D+AKGM YLH +H LKS N V+ + V+KI D
Sbjct: 96 SNRSEE----MDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICD 151
Query: 633 FGCNSILPPKKDL-------WTAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSC 685
FG + + W APE ++ +S+ D YSYG++ E++ R+ F L
Sbjct: 152 FGASRFHNHTTHMSLVGTFPWMAPEVIQSLPVSETCDTYSYGVVLWEMLTREVPFKGLEG 211
Query: 686 RDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKI---- 741
+ + P F E L+ CWE D +KRP FK+I
Sbjct: 212 LQVAWLVVEKNERLTIPSSCPRSFAE-----------LLHQCWEADAKKRPSFKQIISIL 260
Query: 742 -----ETTLAKIFGLFHDQKNE--SYMDTLIRRLQLYSRNL----EHLVEERTQLYKAER 790
+T+L F K E ++ + RL+ R+L + L E +L E+
Sbjct: 261 ESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERDLSFKEQELKERERRLKMWEQ 320
Query: 791 DRADRLNFMLLPRLVVKSLKEKGF 814
++ N LL L + +E F
Sbjct: 321 KLTEQSNTPLLLPLAARMSEESYF 344
>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
Length = 986
Score = 88.2 bits (217), Expect = 4e-17
Identities = 91/402 (22%), Positives = 160/402 (39%), Gaps = 55/402 (13%)
Query: 385 SVDTKKYKVLLTYDTHVNKTYPV---DMSPTFTWKNSKLPNDITGRGPQILMIAVFTLTG 441
+ D K L +Y HV D S + +P+ I G G ++ V
Sbjct: 497 NTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGS 556
Query: 442 AVVLLLLVALLMLRKYRKDYELRQKKWSHIPPEN------IFPLETNETNHVSLKIDDDK 495
V++++L+A ++ + R Y +++ N + P + N + +
Sbjct: 557 VVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEI 616
Query: 496 RRDTIQRLR-------------QCKYDKKRVILKDLKHNDGNFTEKQK----IELNKLLQ 538
I+ + + K KR I +K +T+KQ+ E + + Q
Sbjct: 617 DASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQ 676
Query: 539 IDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIA 598
D+ N+ G V + + EY E GSL L DG F + + +L I
Sbjct: 677 FDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKN----DGRFTVIQL-VGMLRGIG 731
Query: 599 KGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDL------------W 646
GM YL S + VH L + N +V+S +V K++DFG + +L + W
Sbjct: 732 SGMKYL-SDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRW 790
Query: 647 TAPEHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRP 706
TAPE + + DV+SYGI+ E++ E Y + + N + +K
Sbjct: 791 TAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPY-----------WDMSNQDVIKAIEE 839
Query: 707 DLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKI 748
L + + ++ L+ +CW+++ RP F +I L K+
Sbjct: 840 GYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKL 881
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
sapiens]
Length = 986
Score = 87.8 bits (216), Expect = 5e-17
Identities = 72/260 (27%), Positives = 113/260 (43%), Gaps = 35/260 (13%)
Query: 507 KYDKKRVILKDLKHNDGNFTEKQK----IELNKLLQIDYYNLTKFYGTVKLDTMIFGVIE 562
K KR I +K +TEKQ+ E + + Q D+ N+ G V T + + E
Sbjct: 641 KLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITE 700
Query: 563 YCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVV 622
+ E GSL L DG F + + +L IA GM YL + VH L + N +V
Sbjct: 701 FMENGSLDSFLRQN----DGQFTVIQL-VGMLRGIAAGMKYL-ADMNYVHRDLAARNILV 754
Query: 623 DSRMVVKITDFGCNSILPPKKD--------------LWTAPEHLRQANISQKGDVYSYGI 668
+S +V K++DFG + L WTAPE ++ + DV+SYGI
Sbjct: 755 NSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGI 814
Query: 669 IAQEIILRKETFYTLSCRDRNEKIFRVENSNGMKPFRPDLFLETAEEKELEVYLLVKNCW 728
+ E++ E Y + + N + + D L + ++ L+ +CW
Sbjct: 815 VMWEVMSYGERPY-----------WDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCW 863
Query: 729 EEDPEKRPDFKKIETTLAKI 748
++D RP F +I TL K+
Sbjct: 864 QKDRNHRPKFGQIVNTLDKM 883
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,111,345
Number of Sequences: 37866
Number of extensions: 1705075
Number of successful extensions: 5183
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 181
Number of HSP's successfully gapped in prelim test: 375
Number of HSP's that attempted gapping in prelim test: 4228
Number of HSP's gapped (non-prelim): 694
length of query: 1073
length of database: 18,247,518
effective HSP length: 113
effective length of query: 960
effective length of database: 13,968,660
effective search space: 13409913600
effective search space used: 13409913600
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.