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Search of human proteins with 22027642
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
(624 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 1295 0.0
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 1295 0.0
gi|40807500 kelch-like 20 [Homo sapiens] 393 e-109
gi|38194229 kelch-like 17 [Homo sapiens] 373 e-103
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 368 e-102
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 368 e-102
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 366 e-101
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 366 e-101
gi|11056006 kelch-like 12 [Homo sapiens] 365 e-101
gi|14780904 kelch-like 1 protein [Homo sapiens] 360 3e-99
gi|55925604 kelch-like 18 [Homo sapiens] 358 1e-98
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 353 3e-97
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 352 4e-97
gi|166235129 kelch-like 3 [Homo sapiens] 351 1e-96
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 342 5e-94
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 334 1e-91
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 328 7e-90
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 319 4e-87
gi|148664209 kelch-like 10 [Homo sapiens] 305 8e-83
gi|223890235 intracisternal A particle-promoted polypeptide isof... 303 4e-82
gi|34101268 kelch-like 8 [Homo sapiens] 301 1e-81
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 267 2e-71
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 261 2e-69
gi|24308181 kelch-like 9 [Homo sapiens] 241 1e-63
gi|45643138 kelch-like 13 [Homo sapiens] 234 2e-61
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 233 3e-61
gi|40255071 kelch-like 23 [Homo sapiens] 220 3e-57
gi|40018614 DRE1 protein [Homo sapiens] 218 1e-56
gi|8922854 kelch-like 26 [Homo sapiens] 217 2e-56
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 214 2e-55
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 1295 bits (3351), Expect = 0.0
Identities = 624/624 (100%), Positives = 624/624 (100%)
Query: 1 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT 60
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
Sbjct: 1 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT 60
Query: 61 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM 120
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
Sbjct: 61 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM 120
Query: 121 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
Sbjct: 121 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
Query: 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR 240
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
Sbjct: 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR 240
Query: 241 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY 300
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
Sbjct: 241 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY 300
Query: 301 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV 360
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
Sbjct: 301 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV 360
Query: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
Sbjct: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
Query: 421 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG 480
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
Sbjct: 421 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG 480
Query: 481 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE 540
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
Sbjct: 481 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE 540
Query: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600
Query: 601 RSGVGVAVTMEPCRKQIDQQNCTC 624
RSGVGVAVTMEPCRKQIDQQNCTC
Sbjct: 601 RSGVGVAVTMEPCRKQIDQQNCTC 624
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 1295 bits (3351), Expect = 0.0
Identities = 624/624 (100%), Positives = 624/624 (100%)
Query: 1 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT 60
MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
Sbjct: 1 MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT 60
Query: 61 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM 120
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
Sbjct: 61 KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM 120
Query: 121 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
Sbjct: 121 EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD 180
Query: 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR 240
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
Sbjct: 181 PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR 240
Query: 241 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY 300
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
Sbjct: 241 CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY 300
Query: 301 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV 360
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
Sbjct: 301 LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV 360
Query: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
Sbjct: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
Query: 421 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG 480
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
Sbjct: 421 IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG 480
Query: 481 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE 540
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
Sbjct: 481 TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE 540
Query: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600
Query: 601 RSGVGVAVTMEPCRKQIDQQNCTC 624
RSGVGVAVTMEPCRKQIDQQNCTC
Sbjct: 601 RSGVGVAVTMEPCRKQIDQQNCTC 624
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 393 bits (1010), Expect = e-109
Identities = 226/573 (39%), Positives = 326/573 (56%), Gaps = 18/573 (3%)
Query: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Y + H +Q ++N LR ++LCDV L V A + AH+V+L++ SP F+AMFT
Sbjct: 45 YISDKHPRQTLEVINLLRKHRELCDVVLVVG-----AKKIYAHRVILSACSPYFRAMFTG 99
Query: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
L E V I I + ME LI+FAYT+ I++ E V ++ A + Q+ + AC +
Sbjct: 100 ELAESRQTEVVIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCE 159
Query: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
FL +QLDPSN +GI FA+ C EL + A ++ +F EV + EEF L QL+ +IS
Sbjct: 160 FLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIIS 219
Query: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
D+LNVR E +VF+A + WVKY ++RR + +L+ VR L+P FL + +++S
Sbjct: 220 SDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKS 279
Query: 294 DSRCKDYLVKIFEELTLHKPTQVM------PCRAPKVGRLIYTAGGYFR-QSLSYLEAYN 346
D C+D + + L L + +M P + + G +++ GG+ ++S +E Y+
Sbjct: 280 DEECRDLVDEAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYD 339
Query: 347 PSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSP- 405
P W +A + R G+ V+ LLYAVGG DG++ ++++ Y+P TNQWS
Sbjct: 340 PQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGH----DGSSYLNSVERYDPKTNQWSSD 395
Query: 406 CAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGV 465
AP S R +GV V+ G +YAVGG G N VERY+P+ ++W VA M TRR+GV V
Sbjct: 396 VAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAV 455
Query: 466 AVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525
AVL LYAVGG DGT+ LN+ E Y P+ N W I M T R G V + IYA GG
Sbjct: 456 AVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGR 515
Query: 526 DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYD 585
D +L+S ERY+ T W+ V M RRS +G+ V G++ +GG+DG T+L ++E +D
Sbjct: 516 DDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFD 575
Query: 586 PDTDTWSEVTRMTSGRSGVGVAV-TMEPCRKQI 617
PD +TW M R G GV V M C I
Sbjct: 576 PDANTWRLYGGMNYRRLGGGVGVIKMTHCESHI 608
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 373 bits (958), Expect = e-103
Identities = 218/557 (39%), Positives = 309/557 (55%), Gaps = 16/557 (2%)
Query: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
H AF M+ +R LCD+ L V A + AHKVVLAS SP F AMFTN + E
Sbjct: 74 HYHDAFVAMSRMRQRGLLCDIVLHVA-----AKEIRAHKVVLASCSPYFHAMFTNEMSES 128
Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
V++ I P+ +++L++FAYTA I +GE V ++ A + Q++ V AC FL+ Q
Sbjct: 129 RQTHVTLHDIDPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQ 188
Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
LDPSN +GI FA+ C +L + A Y+ HF +VAK EEF L Q++ L+S D LN
Sbjct: 189 LDPSNCLGIRGFADAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLN 248
Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
V E EV+ A ++WVK+D + RR +V L++ VR L+ +FL + +++ CK
Sbjct: 249 VPSEEEVYRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCK 308
Query: 299 DYLVKIFEELTLHKPTQVM------PCRAPKVGRLIYTAGGYFRQSL-SYLEAYNPSDGT 351
D L++ + L + V+ P R G +++ GG ++ EAY+
Sbjct: 309 DLLIEALKFHLLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDR 368
Query: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
W +A + R+ + VG LYAVGG DG +D + ++ Y+P+TN W P M
Sbjct: 369 WHVVASMSTRRARVGVAAVGNRLYAVGGY----DGTSDLATVESYDPVTNTWQPEVSMGT 424
Query: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
R+ +GV + G +Y+ GG G NS ERY+P W VA M TRR V VA L+
Sbjct: 425 RRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGN 484
Query: 472 LYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
LYAVGG+D ++ L + E Y P+ N W + +M + RS AGV VL +Y AGG DG L
Sbjct: 485 LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCL 544
Query: 532 NSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
NSVERY + W VAPM RRS + G +Y +GG DG + L+S+E Y+P T+ W
Sbjct: 545 NSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKW 604
Query: 592 SEVTRMTSGRSGVGVAV 608
+ M + RS VGVAV
Sbjct: 605 VAASCMFTRRSSVGVAV 621
Score = 137 bits (345), Expect = 3e-32
Identities = 79/190 (41%), Positives = 105/190 (55%), Gaps = 5/190 (2%)
Query: 327 LIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
L+Y+AGGY S L+ E Y+P GTW +A + R + + G LYAVGG D
Sbjct: 437 LLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGY----D 492
Query: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
++ + ++ Y P N WSP A M R+ GV V++G +Y GG+ G NSVERY P
Sbjct: 493 SSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSP 552
Query: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNT 505
+ W VAPM RR + ++ LYAVGG DG++ LNS E Y P N+W + M T
Sbjct: 553 KAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFT 612
Query: 506 IRSGAGVCVL 515
RS GV VL
Sbjct: 613 RRSSVGVAVL 622
Score = 96.3 bits (238), Expect = 8e-20
Identities = 53/145 (36%), Positives = 77/145 (53%), Gaps = 5/145 (3%)
Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
+Y GGY S L+ +E Y P W +A + RS V+ G LY GG DG
Sbjct: 485 LYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGN----DG 540
Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
+ ++++ Y+P W APM++ R+ + +DG +YAVGG+ G NS+E+Y P
Sbjct: 541 TSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPR 600
Query: 447 RDEWHLVAPMLTRRIGVGVAVLNRL 471
++W + M TRR VGVAVL L
Sbjct: 601 TNKWVAASCMFTRRSSVGVAVLELL 625
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 368 bits (945), Expect = e-102
Identities = 207/560 (36%), Positives = 311/560 (55%), Gaps = 21/560 (3%)
Query: 58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLRE 117
+H +Q F M +QLCDV L + PA H++VL+S S F AMFTN +RE
Sbjct: 155 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPA-----HRLVLSSVSDYFAAMFTNDVRE 209
Query: 118 QGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
E + +EG+ P + LI++AYT + + E + +++ A + Q+ VV AC FL++
Sbjct: 210 ARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 269
Query: 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDL 237
QL PSN +GI +FA+ GC +LH+ A Y HF EV + +EF L ++ L++ DD+
Sbjct: 270 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDM 329
Query: 238 NVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRC 297
N+ E + +A + WV++D EQRR + LL +R L P FL ++ + + D C
Sbjct: 330 NIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIEC 388
Query: 298 KDYLVKI--FEELTLHKPTQVMPCRAPK---VGRLIYTAGGYFRQSLSYLEAYNPSDGTW 352
+ +++ + L +P P P+ VG L G + + +E Y+ W
Sbjct: 389 QKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMW 448
Query: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVP 412
+A++ R V+ LY VGGR DG + ++CYNP T WS PMS
Sbjct: 449 TPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLNTVECYNPKTKTWSVMPPMSTH 504
Query: 413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472
R+ +GV V++G +YAVGG G + N+VER++P+ +W+ VA M T R VGVAVL+ L
Sbjct: 505 RHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKL 564
Query: 473 YAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG-QDQL 531
YAVGG DG++ L S EC+ P N+W + M+ R G GV + +YA GG+D L
Sbjct: 565 YAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL 624
Query: 532 NS-----VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDP 586
S VERYD +T+ WT VA M R A+G+ + ++Y +GGYDG +L++VE YDP
Sbjct: 625 TSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDP 684
Query: 587 DTDTWSEVTRMTSGRSGVGV 606
T+ W++V + GR+G V
Sbjct: 685 QTNEWTQVAPLCLGRAGACV 704
Score = 94.4 bits (233), Expect = 3e-19
Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 5/145 (3%)
Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
+Y GG S L +E ++P W A + R G+ GLLYA+GG +++P
Sbjct: 564 LYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPAS 622
Query: 387 NTDSSALDC---YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
N S DC Y+P T+ W+ A MS+ R+ +GV ++ +YAVGG G + N+VE Y
Sbjct: 623 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 682
Query: 444 EPERDEWHLVAPMLTRRIGVGVAVL 468
+P+ +EW VAP+ R G V +
Sbjct: 683 DPQTNEWTQVAPLCLGRAGACVVTV 707
Score = 87.8 bits (216), Expect = 3e-17
Identities = 42/94 (44%), Positives = 58/94 (61%)
Query: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
++A GG D S+E+YD+ T WT VA M RR G+ V ++YV+GG DG L
Sbjct: 423 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 482
Query: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
++VECY+P T TWS + M++ R G+GVAV P
Sbjct: 483 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 516
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 368 bits (945), Expect = e-102
Identities = 207/560 (36%), Positives = 311/560 (55%), Gaps = 21/560 (3%)
Query: 58 DHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLRE 117
+H +Q F M +QLCDV L + PA H++VL+S S F AMFTN +RE
Sbjct: 201 NHAEQTFKKMENYLRHKQLCDVILVAGDRRIPA-----HRLVLSSVSDYFAAMFTNDVRE 255
Query: 118 QGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQ 177
E + +EG+ P + LI++AYT + + E + +++ A + Q+ VV AC FL++
Sbjct: 256 ARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMK 315
Query: 178 QLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDL 237
QL PSN +GI +FA+ GC +LH+ A Y HF EV + +EF L ++ L++ DD+
Sbjct: 316 QLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDM 375
Query: 238 NVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRC 297
N+ E + +A + WV++D EQRR + LL +R L P FL ++ + + D C
Sbjct: 376 NIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFL-ADMENNVLFRDDIEC 434
Query: 298 KDYLVKI--FEELTLHKPTQVMPCRAPK---VGRLIYTAGGYFRQSLSYLEAYNPSDGTW 352
+ +++ + L +P P P+ VG L G + + +E Y+ W
Sbjct: 435 QKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMW 494
Query: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVP 412
+A++ R V+ LY VGGR DG + ++CYNP T WS PMS
Sbjct: 495 TPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLNTVECYNPKTKTWSVMPPMSTH 550
Query: 413 RNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLL 472
R+ +GV V++G +YAVGG G + N+VER++P+ +W+ VA M T R VGVAVL+ L
Sbjct: 551 RHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKL 610
Query: 473 YAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG-QDQL 531
YAVGG DG++ L S EC+ P N+W + M+ R G GV + +YA GG+D L
Sbjct: 611 YAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNL 670
Query: 532 NS-----VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDP 586
S VERYD +T+ WT VA M R A+G+ + ++Y +GGYDG +L++VE YDP
Sbjct: 671 TSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDP 730
Query: 587 DTDTWSEVTRMTSGRSGVGV 606
T+ W++V + GR+G V
Sbjct: 731 QTNEWTQVAPLCLGRAGACV 750
Score = 94.4 bits (233), Expect = 3e-19
Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 5/145 (3%)
Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
+Y GG S L +E ++P W A + R G+ GLLYA+GG +++P
Sbjct: 610 LYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPAS 668
Query: 387 NTDSSALDC---YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
N S DC Y+P T+ W+ A MS+ R+ +GV ++ +YAVGG G + N+VE Y
Sbjct: 669 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 728
Query: 444 EPERDEWHLVAPMLTRRIGVGVAVL 468
+P+ +EW VAP+ R G V +
Sbjct: 729 DPQTNEWTQVAPLCLGRAGACVVTV 753
Score = 87.8 bits (216), Expect = 3e-17
Identities = 42/94 (44%), Positives = 58/94 (61%)
Query: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
++A GG D S+E+YD+ T WT VA M RR G+ V ++YV+GG DG L
Sbjct: 469 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528
Query: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
++VECY+P T TWS + M++ R G+GVAV P
Sbjct: 529 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 562
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 366 bits (939), Expect = e-101
Identities = 217/564 (38%), Positives = 313/564 (55%), Gaps = 19/564 (3%)
Query: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
H K+AF +MNELR LCDVT+ A + AH+VVLA+ SP F AMFT + E
Sbjct: 42 HMKKAFKVMNELRSQNLLCDVTIV-----AEDMEISAHRVVLAACSPYFHAMFTGEMSES 96
Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
+ V I+ + + LI++ YTA I + E+ V ++ A + Q+ V + C +FL Q
Sbjct: 97 RAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQ 156
Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
L P N +GI FA+ C +L +A Y HF +V EEF NL Q+ +LIS D L
Sbjct: 157 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLT 216
Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
+ E +VF A I WV +D + R+ ++ L+ VR L +L ++++ ++++ S CK
Sbjct: 217 ISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACK 276
Query: 299 DYLVKIF-------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
DYL++ E+ L K + + +L+ GG +++ +E Y+ +
Sbjct: 277 DYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEER 336
Query: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
W ++A+L R + GL++AVGG N G+ +D Y+P+ +QW+ A M
Sbjct: 337 WHQVAELPSRRCRAGMVYMAGLVFAVGGFN----GSLRVRTVDSYDPVKDQWTSVANMRD 392
Query: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
R+ +G V++G +YAVGG G +SVE Y + +EW VAPM TRR VGV V+ L
Sbjct: 393 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 452
Query: 472 LYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
LYAVGG+DG +R L++ ECY NEW I M+T RSGAGV VL+N +YA GG+DG
Sbjct: 453 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 512
Query: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
SVE YD T W VA M R G+ G +YV+GG DG L SVE Y+P TD
Sbjct: 513 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 572
Query: 590 TWSEVTR-MTSGRSGVGVAVTMEP 612
W+ V+ M++GRS GV V +P
Sbjct: 573 KWTVVSSCMSTGRSYAGVTVIDKP 596
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 366 bits (939), Expect = e-101
Identities = 217/564 (38%), Positives = 313/564 (55%), Gaps = 19/564 (3%)
Query: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
H K+AF +MNELR LCDVT+ A + AH+VVLA+ SP F AMFT + E
Sbjct: 38 HMKKAFKVMNELRSQNLLCDVTIV-----AEDMEISAHRVVLAACSPYFHAMFTGEMSES 92
Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
+ V I+ + + LI++ YTA I + E+ V ++ A + Q+ V + C +FL Q
Sbjct: 93 RAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQ 152
Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
L P N +GI FA+ C +L +A Y HF +V EEF NL Q+ +LIS D L
Sbjct: 153 LHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLT 212
Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
+ E +VF A I WV +D + R+ ++ L+ VR L +L ++++ ++++ S CK
Sbjct: 213 ISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACK 272
Query: 299 DYLVKIF-------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
DYL++ E+ L K + + +L+ GG +++ +E Y+ +
Sbjct: 273 DYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEER 332
Query: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
W ++A+L R + GL++AVGG N G+ +D Y+P+ +QW+ A M
Sbjct: 333 WHQVAELPSRRCRAGMVYMAGLVFAVGGFN----GSLRVRTVDSYDPVKDQWTSVANMRD 388
Query: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
R+ +G V++G +YAVGG G +SVE Y + +EW VAPM TRR VGV V+ L
Sbjct: 389 RRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGL 448
Query: 472 LYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
LYAVGG+DG +R L++ ECY NEW I M+T RSGAGV VL+N +YA GG+DG
Sbjct: 449 LYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPL 508
Query: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
SVE YD T W VA M R G+ G +YV+GG DG L SVE Y+P TD
Sbjct: 509 VRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTD 568
Query: 590 TWSEVTR-MTSGRSGVGVAVTMEP 612
W+ V+ M++GRS GV V +P
Sbjct: 569 KWTVVSSCMSTGRSYAGVTVIDKP 592
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 365 bits (938), Expect = e-101
Identities = 209/562 (37%), Positives = 306/562 (54%), Gaps = 18/562 (3%)
Query: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
H K MN LR S LCDVTL+V+ +D PA H++VLA+ S F AMFT+ L E+
Sbjct: 15 HAKSILNSMNSLRKSNTLCDVTLRVEQKDFPA-----HRIVLAACSDYFCAMFTSELSEK 69
Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
G V I+G+ ME L++F YT ++ + + V ++ A + Q+ V +AC +FL Q
Sbjct: 70 GKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQ 129
Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
LDPSN +GI +FAE CV+L Q A + HF EV + EEF LS ++ LI D++
Sbjct: 130 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQ 189
Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
V E VF A INWVK+ ++R + LL+ VR LTP ++ + ++ +C+
Sbjct: 190 VDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCR 249
Query: 299 DYL--VKIFEELTLHKPTQVMPCRAPKVG--RLIYTAGGYFRQS--LSYLEAYNPSDGTW 352
D + K F + P ++G ++ GG+ Q + +E Y+P W
Sbjct: 250 DLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEW 309
Query: 353 LRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQ---WSPCAPM 409
L + R +A + +Y +GG DG + S+++C + ++ W APM
Sbjct: 310 SFLPSITRKRRYVASVSLHDRIYVIGGY----DGRSRLSSVECLDYTADEDGVWYSVAPM 365
Query: 410 SVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLN 469
+V R G + IY GG G H S+ERY+P D+W ++ M T R G G+ V +
Sbjct: 366 NVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVAS 425
Query: 470 RLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
++Y +GG+DG N LNS E Y P W +T M T RSGAGV +L++ IY GG+DG
Sbjct: 426 GVIYCLGGYDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTA 485
Query: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
L+SVE Y++ T++WT V M R +G TV +GR+Y + GYDG++ L S+ECYDP D
Sbjct: 486 HLSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIID 545
Query: 590 TWSEVTRMTSGRSGVGVAVTME 611
+W VT M + R GV V E
Sbjct: 546 SWEVVTSMGTQRCDAGVCVLRE 567
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 360 bits (923), Expect = 3e-99
Identities = 207/571 (36%), Positives = 306/571 (53%), Gaps = 23/571 (4%)
Query: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
Y H +Q F M QQLCDV L V + PA H++VL+S S F AMFT+
Sbjct: 189 YQAVHHAEQTFRKMESYLKQQQLCDVILIVGNRKIPA-----HRLVLSSVSDYFAAMFTS 243
Query: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
+ E E + +EGI P + L++FAYT + + E + +++ A + Q+ VV C
Sbjct: 244 DVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCH 303
Query: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
FL++ L PSN +GI FA+ GC+EL + A Y + EV + +EF L +L L++
Sbjct: 304 FLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLA 363
Query: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
DD+NV E +FHA + WVKYD + R + LL +R L P L L+ + ++
Sbjct: 364 SDDVNVPDEETIFHALMMWVKYDMQSRCNDLSMLLAFIRLPLLPPQIL-ADLENHALFKN 422
Query: 294 DSRCKDYLVKIF------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNP 347
D C+ +++ E TL + + P R VG L G + + +E Y+
Sbjct: 423 DLECQKLILEAMKYHLLPERRTLMQSPRTKP-RKSTVGTLYAVGGMDNNKGATTIEKYDL 481
Query: 348 SDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCA 407
W++ + R V+ L+ +GGR DG + ++CYNP T W+
Sbjct: 482 RTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGR----DGLKTLNTVECYNPKTKTWTVLP 537
Query: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
PMS R+ +GV V++G IYAVGG G + N+VER++P+ +W VA M R VGVA
Sbjct: 538 PMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAA 597
Query: 468 LNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG 527
LN LY+VGG DG++ L+S E Y P N+W M M R G GV +YA GG+D
Sbjct: 598 LNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDA 657
Query: 528 QDQ------LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSV 581
L+ VERYD +T+TWT VAP+ R A+G+ + R+Y +GGYDG T+L+++
Sbjct: 658 PASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTM 717
Query: 582 ECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
E YDP T+ W+++ + GR+G V V +P
Sbjct: 718 ESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 358 bits (918), Expect = 1e-98
Identities = 198/561 (35%), Positives = 297/561 (52%), Gaps = 17/561 (3%)
Query: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
+++ + + +G+M E+R +LCDVTL++ +F AH++VLA+S P F AMFTN
Sbjct: 15 FSVSELPSRGYGVMEEIRRQGKLCDVTLKIGDH-----KFSAHRIVLAASIPYFHAMFTN 69
Query: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
+ E + + ++G+ P +E LI FAY ++++ ++ V ++ GA Q+ S+ AC
Sbjct: 70 DMMECKQDEIVMQGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCT 129
Query: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
FL ++L P N +G+ FAE + C L+ A +I+ HF EV+ EEF L ++ L+S
Sbjct: 130 FLRERLHPKNCLGVRQFAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVS 189
Query: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
RD+LNV+ E +VF A + WV+YD EQR Y+ LL +R P FL ++Q+ ++++
Sbjct: 190 RDELNVKSEEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRC 249
Query: 294 DSRCKDYL-----VKIFEELTLHKPT-QVMPCRAPKVGRLIYTAGGY--FRQSLSYLEAY 345
+C+D + + E H P + P + LIY GG SL+ +E +
Sbjct: 250 CHKCRDLVDEAKDYHLMPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVF 309
Query: 346 NPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSP 405
+P W R + RS + VV GLLYA+GG DG S ++ YNP T+ W+
Sbjct: 310 DPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGY----DGQLRLSTVEAYNPETDTWTR 365
Query: 406 CAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGV 465
M+ R+ +G V+DG IY GG G +SVE Y PE D+W +V M + R GV
Sbjct: 366 VGSMNSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYSPETDKWTVVTSMSSNRSAAGV 425
Query: 466 AVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525
V +Y GG DG +S E Y W M R G L + ++ GGY
Sbjct: 426 TVFEGRIYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY 485
Query: 526 DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYD 585
DG L+ E Y + W + PM RRS + + GR+Y +GGYDG + L SVE YD
Sbjct: 486 DGSGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYD 545
Query: 586 PDTDTWSEVTRMTSGRSGVGV 606
P+TD W+ + M GVGV
Sbjct: 546 PETDCWTFMAPMACHEGGVGV 566
Score = 77.4 bits (189), Expect = 4e-14
Identities = 48/142 (33%), Positives = 69/142 (48%), Gaps = 5/142 (3%)
Query: 328 IYTAGGYFR-QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
IY +GG+ Q S +E YN TW A + R +G ++ GG DG
Sbjct: 432 IYVSGGHDGLQIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGY----DG 487
Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
+ S + Y+ + +QW PM R+R+ + G +YAVGG G + +SVE Y+PE
Sbjct: 488 SGFLSIAEMYSSVADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPE 547
Query: 447 RDEWHLVAPMLTRRIGVGVAVL 468
D W +APM GVGV +
Sbjct: 548 TDCWTFMAPMACHEGGVGVGCI 569
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 353 bits (905), Expect = 3e-97
Identities = 206/559 (36%), Positives = 308/559 (55%), Gaps = 18/559 (3%)
Query: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
H++Q +N LR +LCD+ L+V + AHKVVLAS SP FKAMFT L E+
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRVG-----DVKIHAHKVVLASVSPYFKAMFTGNLSEK 71
Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
V + I ++ ++E+AYT ++ + + V ++ A + QI V++ C FL Q
Sbjct: 72 ENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQ 131
Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
LDP N IGI+ FAE GC +L+ A +YI +F V + EEFF L+H L ++S D LN
Sbjct: 132 LDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLN 191
Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
V E VF+A +W+KYD ++R+ Y+ LL +VR L+ FL + +++ D CK
Sbjct: 192 VATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCK 251
Query: 299 DYLVKIFE-----ELTLHKPTQVM--PCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
L + + E L T +M P APKV + G F L +E Y P + +
Sbjct: 252 HLLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLF-ACLDSVEMYFPQNDS 310
Query: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGG-RNNSPDGNT---DSSALDCYNPMTNQWSPCA 407
W+ LA L +PR CV+ +Y +GG N G T ++++C+NP TN W+
Sbjct: 311 WIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLE 370
Query: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
M+ R+ +GV V+ G +YA+GG G + SVE+Y P+ +W VAPM T R AV
Sbjct: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
Query: 468 LNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG 527
L+ ++YA+GG+ G +NS E Y P ++ W M+ +M R GV V+ I+ GG++G
Sbjct: 431 LDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNG 489
Query: 528 QDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPD 587
L+S+ERYD WT PMK R+ +G V +YV+GG+ G ++L++V+ YDP
Sbjct: 490 VSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPI 549
Query: 588 TDTWSEVTRMTSGRSGVGV 606
+DTW + M R G+
Sbjct: 550 SDTWLDSAGMIYCRCNFGL 568
Score = 134 bits (336), Expect = 3e-31
Identities = 80/195 (41%), Positives = 101/195 (51%), Gaps = 14/195 (7%)
Query: 427 AVGGSHG---CIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR 483
AVGG G C+ +SVE Y P+ D W +AP+ R G+ VL++ +Y +GG R
Sbjct: 287 AVGGKSGLFACL--DSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVR 344
Query: 484 L--------NSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVE 535
NS EC+ P+ N W + MN RS GV VL +YA GGYDGQ L SVE
Sbjct: 345 PGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVE 404
Query: 536 RYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVT 595
+Y + W VAPM RS V G IY +GGY G ++SVE YDP D+W V
Sbjct: 405 KYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-GPAHMNSVERYDPSKDSWEMVA 463
Query: 596 RMTSGRSGVGVAVTM 610
M R GV V +
Sbjct: 464 SMADKRIHFGVGVML 478
Score = 122 bits (307), Expect = 8e-28
Identities = 68/189 (35%), Positives = 101/189 (53%), Gaps = 6/189 (3%)
Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
+Y GGY QS L +E Y P W +A + RS A V+ G++YA+GG G
Sbjct: 388 LYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-----G 442
Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
++++ Y+P + W A M+ R GVGV+ G I+ VGG +G H +S+ERY+P
Sbjct: 443 PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPH 502
Query: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTI 506
+++W + PM R GVG AV++ LY VGG G++ LN+ + Y P + W M
Sbjct: 503 QNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYC 562
Query: 507 RSGAGVCVL 515
R G+ L
Sbjct: 563 RCNFGLTAL 571
Score = 98.6 bits (244), Expect = 2e-20
Identities = 57/148 (38%), Positives = 77/148 (52%), Gaps = 9/148 (6%)
Query: 470 RLLYAVGGFDGTNR-LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDG- 527
++L AVGG G L+S E Y+P+ + W + +N R G+CVL +Y GG
Sbjct: 283 KVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATN 342
Query: 528 -------QDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDS 580
+ NSVE ++ +T TWT + M RS LG+ V G +Y LGGYDG ++L S
Sbjct: 343 VRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQS 402
Query: 581 VECYDPDTDTWSEVTRMTSGRSGVGVAV 608
VE Y P W V MT+ RS AV
Sbjct: 403 VEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 352 bits (904), Expect = 4e-97
Identities = 194/521 (37%), Positives = 294/521 (56%), Gaps = 16/521 (3%)
Query: 97 KVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVM 156
++VL+S S F AMFTN +RE E + +EG+ P + LI++AYT + + E + ++
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 157 NGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAK 216
+ A + Q+ VV AC FL++QL PSN +GI +FA+ GC +LH+ A Y HF EV +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 217 QEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSL 276
+EF L ++ L++ DD+N+ E + +A + WV++D EQRR + LL +R L
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 277 TPNFLQMQLQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPK---VGRLIYTA 331
P FL ++ + + D C+ +++ + L +P P P+ VG L
Sbjct: 354 APQFL-ADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVG 412
Query: 332 GGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSS 391
G + + +E Y+ W +A++ R V+ LY VGGR DG +
Sbjct: 413 GMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGR----DGLKTLN 468
Query: 392 ALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWH 451
++CYNP T WS PMS R+ +GV V++G +YAVGG G + N+VER++P+ +W+
Sbjct: 469 TVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWN 528
Query: 452 LVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAG 511
VA M T R VGVAVL+ LYAVGG DG++ L S EC+ P N+W + M+ R G G
Sbjct: 529 FVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVG 588
Query: 512 VCVLHNCIYAAGGYDG-QDQLNS-----VERYDVETETWTFVAPMKHRRSALGITVHQGR 565
V + +YA GG+D L S VERYD +T+ WT VA M R A+G+ + +
Sbjct: 589 VTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDK 648
Query: 566 IYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
+Y +GGYDG +L++VE YDP T+ W++V + GR+G V
Sbjct: 649 LYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 689
Score = 94.4 bits (233), Expect = 3e-19
Identities = 52/145 (35%), Positives = 78/145 (53%), Gaps = 5/145 (3%)
Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
+Y GG S L +E ++P W A + R G+ GLLYA+GG +++P
Sbjct: 549 LYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG-HDAPAS 607
Query: 387 NTDSSALDC---YNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERY 443
N S DC Y+P T+ W+ A MS+ R+ +GV ++ +YAVGG G + N+VE Y
Sbjct: 608 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAY 667
Query: 444 EPERDEWHLVAPMLTRRIGVGVAVL 468
+P+ +EW VAP+ R G V +
Sbjct: 668 DPQTNEWTQVAPLCLGRAGACVVTV 692
Score = 87.8 bits (216), Expect = 3e-17
Identities = 42/94 (44%), Positives = 58/94 (61%)
Query: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
++A GG D S+E+YD+ T WT VA M RR G+ V ++YV+GG DG L
Sbjct: 408 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 467
Query: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
++VECY+P T TWS + M++ R G+GVAV P
Sbjct: 468 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGP 501
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 351 bits (900), Expect = 1e-96
Identities = 212/560 (37%), Positives = 312/560 (55%), Gaps = 19/560 (3%)
Query: 59 HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQ 118
H +AF +MNELR Q LCDV + A + AH+VVLA+ SP F AMFT + E
Sbjct: 32 HMGKAFKVMNELRSKQLLCDVMIV-----AEDVEIEAHRVVLAACSPYFCAMFTGDMSES 86
Query: 119 GMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQ 178
+ + I+ + + + +LI++ YTA I + E+ V ++ A + Q+ V + C DFL Q
Sbjct: 87 KAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQ 146
Query: 179 LDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLN 238
L P+N +GI FA+ C +L Q+A Y HF EV EEF +LS Q+ +LIS D L
Sbjct: 147 LHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLT 206
Query: 239 VRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK 298
V E +VF A I+W+ Y+ E R ++ L+ VR L ++L +++ ++++++ CK
Sbjct: 207 VSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCK 266
Query: 299 DYLVKI-------FEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGT 351
D+L++ ++ L K + P + +++ GG +++ +E Y+ +
Sbjct: 267 DFLIEAMKYHLLPLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDR 326
Query: 352 WLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSV 411
W ++A+L R + G +YAVGG N G+ +D Y+ + +QW+ A M
Sbjct: 327 WDQIAELPSRRCRAGVVFMAGHVYAVGGFN----GSLRVRTVDVYDGVKDQWTSIASMQE 382
Query: 412 PRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
R+ +G V++ +YAVGG G SVE Y + +EW VAPM TRR VGV V+
Sbjct: 383 RRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGK 442
Query: 472 LYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQD 529
LYAVGG+DG +R L++ E Y P NEW + M+T RSGAGV VL +YA GG+DG
Sbjct: 443 LYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPL 502
Query: 530 QLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTD 589
SVE YD T TW VA M R G+ G +YV+GG DG L SVE Y+P TD
Sbjct: 503 VRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTD 562
Query: 590 TWSEV-TRMTSGRSGVGVAV 608
W+ + T M++GRS GVAV
Sbjct: 563 KWTLLPTNMSTGRSYAGVAV 582
Score = 132 bits (331), Expect = 1e-30
Identities = 79/195 (40%), Positives = 108/195 (55%), Gaps = 4/195 (2%)
Query: 327 LIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPD 385
L+Y GG+ + L+ +EAY+ W +A + RS + VV G LYAVGG + +
Sbjct: 395 LLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGA-- 452
Query: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
S ++ YNP TN+W A MS R+ GVGV+ G +YA GG G + SVE Y+P
Sbjct: 453 SRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDP 512
Query: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMI-TAMN 504
+ W VA M R GV +N LLY VGG DG+ L S E Y P ++W ++ T M+
Sbjct: 513 GTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKWTLLPTNMS 572
Query: 505 TIRSGAGVCVLHNCI 519
T RS AGV V+H +
Sbjct: 573 TGRSYAGVAVIHKSL 587
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 342 bits (878), Expect = 5e-94
Identities = 203/609 (33%), Positives = 312/609 (51%), Gaps = 29/609 (4%)
Query: 23 CPEGAGDAVMYAS-----TECKAEVTPSQHGNRTFS---YTLEDHTKQAFGIMNELRLSQ 74
C + A D M A + + + S+ N T S + + +H +Q M +
Sbjct: 120 CEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEK 179
Query: 75 QLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVME 134
QLCDV L + PA H++VL++ S F AMFTN + E E V +EG+ P +
Sbjct: 180 QLCDVLLIAGHLRIPA-----HRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234
Query: 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194
L+++AYT + + E + ++ A + Q+ V+ CS+FL++QL PSN +GI +F +
Sbjct: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294
Query: 195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
GC EL A +Y HF EV K +EF L ++ L+ DD+NV E +FHA + WV
Sbjct: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354
Query: 255 YDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPT 314
+D + R+ + LL +R L P L L+ + D C+ L++ + L +
Sbjct: 355 HDVQNRQGELGMLLSYIRLPLLPPQLL-ADLETSSMFTGDLECQKLLMEAMKYHLLPERR 413
Query: 315 QVMPC-----RAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV 369
+M R VG L G + + +E Y+ +WL + + R V
Sbjct: 414 SMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
Query: 370 VGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVG 429
+ LY VGGR DG + ++C+NP+ W+ PMS R+ +GV ++G +YAVG
Sbjct: 474 IDNKLYVVGGR----DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
Query: 430 GSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAEC 489
G G + N+VER++PE +W+ VA M T R VGV LN LYA+GG DG++ L S E
Sbjct: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
Query: 490 YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ------LNSVERYDVETET 543
+ P N+W + M+ R G GV + +Y GG+D + VERYD + ++
Sbjct: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
Query: 544 WTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSG 603
W+ VAP+ R A+ + ++YV+GGYDGHT+L++VE YD + W E + GR+G
Sbjct: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVNIGRAG 709
Query: 604 VGVAVTMEP 612
V V P
Sbjct: 710 ACVVVVKLP 718
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 334 bits (857), Expect = 1e-91
Identities = 197/590 (33%), Positives = 304/590 (51%), Gaps = 29/590 (4%)
Query: 23 CPEGAGDAVMYAS-----TECKAEVTPSQHGNRTFS---YTLEDHTKQAFGIMNELRLSQ 74
C + A D M A + + + S+ N T S + + +H +Q M +
Sbjct: 120 CEKRAQDLEMMADDNIEDSTARLDTQHSEDMNATRSEEQFHVINHAEQTLRKMENYLKEK 179
Query: 75 QLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVME 134
QLCDV L + PA H++VL++ S F AMFTN + E E V +EG+ P +
Sbjct: 180 QLCDVLLIAGHLRIPA-----HRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPNALN 234
Query: 135 RLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQI 194
L+++AYT + + E + ++ A + Q+ V+ CS+FL++QL PSN +GI +F +
Sbjct: 235 SLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFGDAQ 294
Query: 195 GCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEVFHACINWVK 254
GC EL A +Y HF EV K +EF L ++ L+ DD+NV E +FHA + WV
Sbjct: 295 GCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQWVG 354
Query: 255 YDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPT 314
+D + R+ + LL +R L P L L+ + D C+ L++ + L +
Sbjct: 355 HDVQNRQGELGMLLSYIRLPLLPPQLL-ADLETSSMFTGDLECQKLLMEAMKYHLLPERR 413
Query: 315 QVMPC-----RAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCV 369
+M R VG L G + + +E Y+ +WL + + R V
Sbjct: 414 SMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
Query: 370 VGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVG 429
+ LY VGGR DG + ++C+NP+ W+ PMS R+ +GV ++G +YAVG
Sbjct: 474 IDNKLYVVGGR----DGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
Query: 430 GSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAEC 489
G G + N+VER++PE +W+ VA M T R VGV LN LYA+GG DG++ L S E
Sbjct: 530 GHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEY 589
Query: 490 YYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ------LNSVERYDVETET 543
+ P N+W + M+ R G GV + +Y GG+D + VERYD + ++
Sbjct: 590 FDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYDPKGDS 649
Query: 544 WTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSE 593
W+ VAP+ R A+ + ++YV+GGYDGHT+L++VE YD + W E
Sbjct: 650 WSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKE 699
Score = 153 bits (386), Expect = 5e-37
Identities = 79/199 (39%), Positives = 111/199 (55%), Gaps = 1/199 (0%)
Query: 409 MSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVL 468
M PR + + G +YAVGG ++E+Y+ + W + M RR+ GVAV+
Sbjct: 416 MQSPRTKPRKSTV-GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVI 474
Query: 469 NRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQ 528
+ LY VGG DG LN+ EC+ P W ++ M+T R G GV L +YA GG+DG
Sbjct: 475 DNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVGGHDGW 534
Query: 529 DQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDT 588
LN+VER+D E W +VA M RS +G+ ++Y +GG DG + L S+E +DP T
Sbjct: 535 SYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSSCLKSMEYFDPHT 594
Query: 589 DTWSEVTRMTSGRSGVGVA 607
+ WS M+ R GVGVA
Sbjct: 595 NKWSLCAPMSKRRGGVGVA 613
Score = 77.0 bits (188), Expect = 5e-14
Identities = 34/94 (36%), Positives = 54/94 (57%)
Query: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL 578
+YA GG D ++E+YD+ T +W + M RR G+ V ++YV+GG DG L
Sbjct: 431 LYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTL 490
Query: 579 DSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
++VEC++P W+ + M++ R G+GVA P
Sbjct: 491 NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGP 524
Score = 33.5 bits (75), Expect = 0.60
Identities = 16/45 (35%), Positives = 23/45 (51%)
Query: 564 GRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
G +Y +GG D ++E YD T++W + M R GVAV
Sbjct: 429 GALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQFGVAV 473
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 328 bits (842), Expect = 7e-90
Identities = 200/590 (33%), Positives = 310/590 (52%), Gaps = 55/590 (9%)
Query: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
++ + H + +N++R Q CDV LQV + F AH++VLA+SSP F A+FT
Sbjct: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQES-----FKAHRLVLAASSPYFAALFTG 68
Query: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
G++E +VV I GI + + L++F YT +++G V ++ A M Q+ VV C +
Sbjct: 69 GMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCE 128
Query: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
FL Q+DP N IGI F+EQI C +L + + YI++HF EV EEF L+ QL+ ++
Sbjct: 129 FLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILR 188
Query: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
++L++ E +VF A + W+ D +RR +V +L +R L P +L+
Sbjct: 189 SEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQ---------RLLKY 239
Query: 294 DSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRL------------------IYTAGGYF 335
D+ +++ + L + +V C++PK + +Y GGY
Sbjct: 240 IEGVSDFNLRVALQTLLKEYCEV--CKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYT 297
Query: 336 R---------QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
R ++LS +E ++ W ++ L RSGL V+GG++YA+GG +S
Sbjct: 298 RLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDS--- 354
Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
+CY+P+T QW+ A M+ PR +GV V G IYA+GG G N++ER++P+
Sbjct: 355 -MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPD 413
Query: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEWRMITAMNT 505
++W +V M R G + L+Y +GG L S E Y P W + M T
Sbjct: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473
Query: 506 IRSGAGVCVLHNCIYAAGGY-DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
R+ GV L++CIY+ GG+ + QD L++VE+Y E E W VA MK R+ + + G
Sbjct: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
Query: 565 RIYVLGG-YDGHTF-----LDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
+YV GG H F LDSVE Y+P +DTW+E+ M + R GVAV
Sbjct: 534 LLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGVAV 583
Score = 102 bits (255), Expect = 8e-22
Identities = 64/198 (32%), Positives = 99/198 (50%), Gaps = 15/198 (7%)
Query: 328 IYTAGGYFRQSL-SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
IY GG+ + + +E ++P + W + ++ V R C + GL+Y +GG +N
Sbjct: 392 IYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNE--- 448
Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG---SHGCIHHNSVERY 443
+ + + Y+P++ +WSP PM R +GV ++ IY+VGG + +H +VE+Y
Sbjct: 449 GIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALH--TVEKY 506
Query: 444 EPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGG------FDGTNRLNSAECYYPERNEW 497
E ++W VA M R G+ V +N LLY GG F L+S E Y P + W
Sbjct: 507 SFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTW 566
Query: 498 RMITAMNTIRSGAGVCVL 515
I M T R GV VL
Sbjct: 567 TEIGNMITSRCEGGVAVL 584
Score = 65.1 bits (157), Expect = 2e-10
Identities = 47/150 (31%), Positives = 68/150 (45%), Gaps = 11/150 (7%)
Query: 327 LIYTAGGYFRQSLSY--LEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSP 384
LIY GG + + E Y+P W L + R+ L + +Y+VGG N +
Sbjct: 438 LIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
Query: 385 DGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGG---SHGCIHH---N 438
D ++ Y+ +W A M VPR + V ++G +Y GG SH + +
Sbjct: 498 DA---LHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPGTLD 554
Query: 439 SVERYEPERDEWHLVAPMLTRRIGVGVAVL 468
SVE Y P D W + M+T R GVAVL
Sbjct: 555 SVEVYNPHSDTWTEIGNMITSRCEGGVAVL 584
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 319 bits (818), Expect = 4e-87
Identities = 189/508 (37%), Positives = 279/508 (54%), Gaps = 14/508 (2%)
Query: 115 LREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDF 174
+ E + V I+ + + LI++ YTA I + E+ V ++ A + Q+ V + C +F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 175 LVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISR 234
L QL P N +GI FA+ C +L +A Y HF +V EEF NL Q+ +LIS
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 235 DDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSD 294
D L + E +VF A I WV +D + R+ ++ L+ VR L +L ++++ ++++
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 295 SRCKDYLVKIF-------EELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNP 347
S CKDYL++ E+ L K + + +L+ GG +++ +E Y+
Sbjct: 181 SACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDF 240
Query: 348 SDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCA 407
+ W ++A+L R + GL++AVGG N G+ +D Y+P+ +QW+ A
Sbjct: 241 KEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFN----GSLRVRTVDSYDPVKDQWTSVA 296
Query: 408 PMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAV 467
M R+ +G V++G +YAVGG G +SVE Y + +EW VAPM TRR VGV V
Sbjct: 297 NMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGV 356
Query: 468 LNRLLYAVGGFDGTNR--LNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGY 525
+ LLYAVGG+DG +R L++ ECY NEW I M+T RSGAGV VL+N +YA GG+
Sbjct: 357 VGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 416
Query: 526 DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYD 585
DG SVE YD T W VA M R G+ G +YV+GG DG L SVE Y+
Sbjct: 417 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
Query: 586 PDTDTWSEVTR-MTSGRSGVGVAVTMEP 612
P TD W+ V+ M++GRS GV V +P
Sbjct: 477 PTTDKWTVVSSCMSTGRSYAGVTVIDKP 504
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 305 bits (781), Expect = 8e-83
Identities = 181/553 (32%), Positives = 288/553 (52%), Gaps = 19/553 (3%)
Query: 66 IMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI 125
I NELRL +LCDV ++V +F AHK +L S S F+A+FT+G +V +I
Sbjct: 28 IFNELRLEGKLCDVVIKVN-----GFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNI 82
Query: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
GI P +M+ +IE+AYT ++ + V ++ A + I +VR C +FL +L N I
Sbjct: 83 PGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCI 142
Query: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAK-QEEFFNLSHCQLVTLISRDDLNVRCESE 244
GI F + C EL Q+A +I +F E+ K EF LS +L +I +D+LNV+ E
Sbjct: 143 GICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDA 202
Query: 245 VFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLV-- 302
VF A + W+ +D + R+ ++ LL VR + + ++ + ++ CK ++
Sbjct: 203 VFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINA 262
Query: 303 -KIFEELTLHKPTQ---VMPCRAPKVG-RLIYTAGGYFRQS-LSYLEAYNPSDGTWLRLA 356
K +L ++ P+ P P++ +++ GG+ S + +EAY+ W+ +
Sbjct: 263 LKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVT 322
Query: 357 -DLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNR 415
+ + PR+ + G +Y +GG ++ N+ + ++P+ W APM R
Sbjct: 323 CEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNS----VKRFDPVKKTWHQVAPMHSRRCY 378
Query: 416 IGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV 475
+ V V+ IYA+GG G + N+ ERYEPE ++W L+APM +R L +Y
Sbjct: 379 VSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYIC 438
Query: 476 GGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVE 535
GGF+G L +AE Y E N+W +I M + RSG GV +YA GG+DG ++L S E
Sbjct: 439 GGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAE 498
Query: 536 RYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVT 595
Y TW + M + RS GI V ++V+GG++G T +VECYD TD W +
Sbjct: 499 AYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAH 558
Query: 596 RMTSGRSGVGVAV 608
M+ RS + V
Sbjct: 559 DMSIYRSALSCCV 571
Score = 30.8 bits (68), Expect = 3.9
Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 1/51 (1%)
Query: 324 VGRLIYTAGGYFRQSLSY-LEAYNPSDGTWLRLADLQVPRSGLAGCVVGGL 373
V L++ GG+ + ++ +E Y+ W D+ + RS L+ CVV GL
Sbjct: 525 VDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGL 575
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 303 bits (775), Expect = 4e-82
Identities = 190/574 (33%), Positives = 297/574 (51%), Gaps = 57/574 (9%)
Query: 54 YTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTN 113
++ + H + +N++R Q CDV LQV + F AH++VLA+SSP F A+FT
Sbjct: 14 FSSDKHAQLILAQINKMRNGQHFCDVQLQVGQES-----FKAHRLVLAASSPYFAALFTG 68
Query: 114 GLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSD 173
G++E +VV I GI + + L++F YT +++G V ++ A M Q+ VV C +
Sbjct: 69 GMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCE 128
Query: 174 FLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLIS 233
FL Q+DP N IGI F+EQI C +L + + YI++HF EV EEF L+ QL+ ++
Sbjct: 129 FLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLIKILR 188
Query: 234 RDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQS 293
++L++ E +VF A + W+ D +RR +V +L +R L P +L+
Sbjct: 189 SEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQ---------RLLKY 239
Query: 294 DSRCKDYLVKIFEELTLHKPTQVMPCRAPKVGRL------------------IYTAGGYF 335
D+ +++ + L + +V C++PK + +Y GGY
Sbjct: 240 IEGVSDFNLRVALQTLLKEYCEV--CKSPKENKFCSFLQTSKVRPRKKARKYLYAVGGYT 297
Query: 336 R---------QSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
R ++LS +E ++ W ++ L RSGL V+GG++YA+GG +S
Sbjct: 298 RLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDS--- 354
Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
+CY+P+T QW+ A M+ PR +GV V G IYA+GG G N++ER++P+
Sbjct: 355 -MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPD 413
Query: 447 RDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN-RLNSAECYYPERNEWRMITAMNT 505
++W +V M R G + L+Y +GG L S E Y P W + M T
Sbjct: 414 ENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLPPMGT 473
Query: 506 IRSGAGVCVLHNCIYAAGGY-DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
R+ GV L++CIY+ GG+ + QD L++VE+Y E E W VA MK R+ + + G
Sbjct: 474 RRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNG 533
Query: 565 RIYVLGG-YDGHTFLDSVECYDPDTDTWSEVTRM 597
+YV GG H FL PDT + EV R+
Sbjct: 534 LLYVSGGRSSSHDFL------APDTHRY-EVFRL 560
Score = 86.7 bits (213), Expect = 6e-17
Identities = 49/140 (35%), Positives = 69/140 (49%), Gaps = 8/140 (5%)
Query: 470 RLLYAVGGF--------DGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYA 521
+ LYAVGG+ + L+ E + W +++++ RSG GV VL +YA
Sbjct: 288 KYLYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYA 347
Query: 522 AGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSV 581
GG + E YD T+ WT VA M H R LG+ V G IY LGG+ G +++
Sbjct: 348 IGGEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTI 407
Query: 582 ECYDPDTDTWSEVTRMTSGR 601
E +DPD + W V M R
Sbjct: 408 ERFDPDENKWEVVGNMAVSR 427
Score = 74.3 bits (181), Expect = 3e-13
Identities = 38/98 (38%), Positives = 50/98 (51%), Gaps = 8/98 (8%)
Query: 519 IYAAGGY--------DGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLG 570
+YA GGY L+ VER+D ++ WT V+ + RS LG+TV G +Y +G
Sbjct: 290 LYAVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIG 349
Query: 571 GYDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
G D ECYDP T W+ V M R G+GV V
Sbjct: 350 GEKDSMIFDCTECYDPVTKQWTTVASMNHPRCGLGVCV 387
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 301 bits (771), Expect = 1e-81
Identities = 182/571 (31%), Positives = 291/571 (50%), Gaps = 20/571 (3%)
Query: 48 GNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVF 107
G +F + + K G + + +LCDVTL+V + HK+VLA P F
Sbjct: 38 GEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVG-----SKLISCHKLVLACVIPYF 92
Query: 108 KAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSV 167
+AMF + + E ++ I +E L++F Y++ +++ V ++ A + Q++ V
Sbjct: 93 RAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELV 152
Query: 168 VRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQ 227
RAC +++ PSN + + FAE ++L A +Y HF EV + E+F ++S
Sbjct: 153 ARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQH 212
Query: 228 LVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQK 287
L L+S DLN+ E +V++A I W+ + + ++ L VR L +FL + K
Sbjct: 213 LHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAK 272
Query: 288 CEILQSDSRCKDYLVKIFEELTLHKPTQVMPC---------RAPKVGRLIYTAG-GYFRQ 337
+I++ + +C+D L + LH ++ +P R G L G G
Sbjct: 273 EQIVKQNLKCRDLLDEA-RNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGD 331
Query: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
+E Y+ + +W ++ R + V G +YAVGG DGN +++ ++
Sbjct: 332 PFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGH----DGNEHLGSMEMFD 387
Query: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
P+TN+W A M+ R I + + G IYA+GG N VERY+ E D+W VAPM
Sbjct: 388 PLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMN 447
Query: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517
T R GVG L +YAVGG DG L+S E Y P ++W + M R+G GV LH
Sbjct: 448 TPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHG 507
Query: 518 CIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF 577
C+Y GG+D L+SVERYD + W +VA + R +GI G+I+ +GG++G+ +
Sbjct: 508 CLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAY 567
Query: 578 LDSVECYDPDTDTWSEVTRMTSGRSGVGVAV 608
L++VE +DP + W V ++ R+G GVAV
Sbjct: 568 LNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598
Score = 90.1 bits (222), Expect = 5e-18
Identities = 50/145 (34%), Positives = 80/145 (55%), Gaps = 5/145 (3%)
Query: 328 IYTAGGYFRQ-SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
+Y GG SLS +E Y+P W+ + ++ R+G + G LY VGG D
Sbjct: 462 VYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGF----DD 517
Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPE 446
N+ S+++ Y+P +N+W A ++ PR +G+ + G I+AVGG +G + N+VE ++P
Sbjct: 518 NSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPV 577
Query: 447 RDEWHLVAPMLTRRIGVGVAVLNRL 471
+ W LV + R G GVAV + L
Sbjct: 578 LNRWELVGSVSHCRAGAGVAVCSCL 602
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 267 bits (683), Expect = 2e-71
Identities = 173/540 (32%), Positives = 268/540 (49%), Gaps = 29/540 (5%)
Query: 65 GIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVS 124
G+MN +R + LCDV L V+ + PA H+VVLA++S F MFT + E V
Sbjct: 32 GVMNNMRKQKTLCDVILMVQERKIPA-----HRVVLAAASHFFNLMFTTNMLESKSFEVE 86
Query: 125 IEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184
++ P ++E+L+EFAYTA IS+ V +++ A YQI+ V + C DFL +Q+D SN
Sbjct: 87 LKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNC 146
Query: 185 IGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESE 244
+GI+ AE + C EL A ++I+ HF EV K +EF L ++ L+++D L VR E +
Sbjct: 147 LGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 206
Query: 245 VFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVK- 303
V+ A + W+KYD R+ ++ +L VR ++ NFL +Q ++Q + C ++
Sbjct: 207 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISG 266
Query: 304 -IFEELTLHKPTQVMPCRAPKVGRLIYTA---GGYFRQSLSYLEAYNPSDGTWLRLADLQ 359
+ L+ +++ P+ + Y GG QS Y +NP D +W D++
Sbjct: 267 MRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRY---FNPKDYSW---TDIR 320
Query: 360 VP--RSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI 416
P + A CV ++Y +GG P +DCYN + + W PR+ +
Sbjct: 321 CPFEKRRDAACVFWDNVVYILGGSQLFP-----IKRMDCYNVVKDSWYSKLGPPTPRDSL 375
Query: 417 GVGVIDGHIYAVGGSH-GCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV 475
+G IY GGS G E Y+ + WH MLT+R G+ N L+Y
Sbjct: 376 AACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVC 435
Query: 476 GGFDGTN----RLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
GG G N LNS E Y P W + M R G+ + + I+A GG +G L
Sbjct: 436 GGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGL 495
Query: 532 NSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
++VE YD++ W V+PM + + +YVL G+ G L + Y+ +TD W
Sbjct: 496 DNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
Score = 85.1 bits (209), Expect = 2e-16
Identities = 61/217 (28%), Positives = 89/217 (41%), Gaps = 6/217 (2%)
Query: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
G + + +NP W+ R D +Y +GGS ++ Y
Sbjct: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMDCYNV 357
Query: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFD-GTNRLNSAECYYPERNEWRMITAMN 504
+D W+ T R + +Y GG + G + L ECY W +M
Sbjct: 358 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSML 417
Query: 505 TIRSGAGVCVLHNCIYAAGGYDGQDQ----LNSVERYDVETETWTFVAPMKHRRSALGIT 560
T R G+ + IY GG G + LNS E YD TETWT + PM R G+
Sbjct: 418 TQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLV 477
Query: 561 VHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRM 597
+ +I+ +GG +G LD+VE YD + W V+ M
Sbjct: 478 FVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 514
Score = 71.6 bits (174), Expect = 2e-12
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 10/190 (5%)
Query: 422 DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGT 481
D I GGS S + P+ W + +R + ++Y +GG
Sbjct: 292 DYRIALFGGSQP----QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-L 346
Query: 482 NRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD-GQDQLNSVERYDVE 540
+ +CY ++ W T R C IY +GG + G L E YD
Sbjct: 347 FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTR 406
Query: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF----LDSVECYDPDTDTWSEVTR 596
TE+W M +R + G+ G IYV GG G+ L+S E YDP T+TW+E+
Sbjct: 407 TESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 466
Query: 597 MTSGRSGVGV 606
M R G+
Sbjct: 467 MIEARKNHGL 476
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 261 bits (666), Expect = 2e-69
Identities = 170/539 (31%), Positives = 266/539 (49%), Gaps = 29/539 (5%)
Query: 66 IMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSI 125
+ + + L + LCDV L V+ + PA H+VVLA++S F MFT + E V +
Sbjct: 11 LTSHINLKKTLCDVILMVQERKIPA-----HRVVLAAASHFFNLMFTTNMLESKSFEVEL 65
Query: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
+ P ++E+L+EFAYTA IS+ V +++ A YQI+ V + C DFL +Q+D SN +
Sbjct: 66 KDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCL 125
Query: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
GI+ AE + C EL A ++I+ HF EV K +EF L ++ L+++D L VR E +V
Sbjct: 126 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 185
Query: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVK-- 303
+ A + W+KYD R+ ++ +L VR ++ NFL +Q ++Q + C ++
Sbjct: 186 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGM 245
Query: 304 IFEELTLHKPTQVMPCRAPKVGRLIYTA---GGYFRQSLSYLEAYNPSDGTWLRLADLQV 360
+ L+ +++ P+ + Y GG QS Y +NP D +W D++
Sbjct: 246 RYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRY---FNPKDYSW---TDIRC 299
Query: 361 P--RSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIG 417
P + A CV ++Y +GG P +DCYN + + W PR+ +
Sbjct: 300 PFEKRRDAACVFWDNVVYILGGSQLFP-----IKRMDCYNVVKDSWYSKLGPPTPRDSLA 354
Query: 418 VGVIDGHIYAVGGSH-GCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVG 476
+G IY GGS G E Y+ + WH MLT+R G+ N L+Y G
Sbjct: 355 ACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCG 414
Query: 477 GFDGTN----RLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLN 532
G G N LNS E Y P W + M R G+ + + I+A GG +G L+
Sbjct: 415 GSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLD 474
Query: 533 SVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
+VE YD++ W V+PM + + +YVL G+ G L + Y+ +TD W
Sbjct: 475 NVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 533
Score = 85.1 bits (209), Expect = 2e-16
Identities = 61/217 (28%), Positives = 89/217 (41%), Gaps = 6/217 (2%)
Query: 386 GNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEP 445
G + + +NP W+ R D +Y +GGS ++ Y
Sbjct: 277 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMDCYNV 335
Query: 446 ERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFD-GTNRLNSAECYYPERNEWRMITAMN 504
+D W+ T R + +Y GG + G + L ECY W +M
Sbjct: 336 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSML 395
Query: 505 TIRSGAGVCVLHNCIYAAGGYDGQDQ----LNSVERYDVETETWTFVAPMKHRRSALGIT 560
T R G+ + IY GG G + LNS E YD TETWT + PM R G+
Sbjct: 396 TQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLV 455
Query: 561 VHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRM 597
+ +I+ +GG +G LD+VE YD + W V+ M
Sbjct: 456 FVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 492
Score = 71.6 bits (174), Expect = 2e-12
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 10/190 (5%)
Query: 422 DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGT 481
D I GGS S + P+ W + +R + ++Y +GG
Sbjct: 270 DYRIALFGGSQP----QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-L 324
Query: 482 NRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD-GQDQLNSVERYDVE 540
+ +CY ++ W T R C IY +GG + G L E YD
Sbjct: 325 FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTR 384
Query: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF----LDSVECYDPDTDTWSEVTR 596
TE+W M +R + G+ G IYV GG G+ L+S E YDP T+TW+E+
Sbjct: 385 TESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 444
Query: 597 MTSGRSGVGV 606
M R G+
Sbjct: 445 MIEARKNHGL 454
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 241 bits (616), Expect = 1e-63
Identities = 158/579 (27%), Positives = 264/579 (45%), Gaps = 19/579 (3%)
Query: 40 AEVTPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVV 99
A + P + G F +T H+ ++LR+ LCDVTL D F H+ +
Sbjct: 14 AHLQPCKAGTTRF-FTSNTHSSVVLQGFDQLRIEGLLCDVTLVPGDGDEI---FPVHRAM 69
Query: 100 LASSSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGA 159
+AS+S FKAMFT G++EQ + + + G++ ++++I+F YTA +S+ + + A
Sbjct: 70 MASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLEAA 129
Query: 160 VMYQIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEE 219
QI V+ C FL+ + N + + A +E+ + +I +F + E
Sbjct: 130 SFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLSTGE 189
Query: 220 FFNLSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPN 279
F L +L ++S + L E E+F A W++ + + R Y L++ +R +TP
Sbjct: 190 FLKLPFERLAFVLSSNSLKHCTELELFKAACRWLRLE-DPRMDYAAKLMKNIRFPLMTPQ 248
Query: 280 FLQMQLQKCEILQSDSRCKDYLVKIFEELTLHKPTQVMPCRAPKV---GRLIYTAGGYFR 336
L +Q + +++D+ C + L++ + VM + + T GG R
Sbjct: 249 DLINYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLR 308
Query: 337 QSL---SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN-SPDGNTDSSA 392
Q L L Y+ W LA + PR V+G LY VGG++N G T
Sbjct: 309 QQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDT 368
Query: 393 LDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHL 452
+ ++P N+W A ++ R + + GH+YAVGG +VE Y P +EW
Sbjct: 369 VFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSY 428
Query: 453 VAPMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGV 512
VA M G V L+Y GG N C+ P+ ++W M T+R +
Sbjct: 429 VAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGLHCM 488
Query: 513 CVLHNCIYAAG-----GYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIY 567
C + + +Y G G D + S E Y + WT +A M +S +G+ V + +IY
Sbjct: 489 CTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIY 548
Query: 568 VLGGY--DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGV 604
V+GGY + ++ V+ YDP+ D W +V + G+
Sbjct: 549 VVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGI 587
Score = 104 bits (259), Expect = 3e-22
Identities = 64/198 (32%), Positives = 95/198 (47%), Gaps = 11/198 (5%)
Query: 325 GRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSP 384
G L G L+ +E YNP W +A + P G AG V GGL+Y GG +
Sbjct: 399 GHLYAVGGRSAAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITH-- 456
Query: 385 DGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSV-- 440
+T + L C++P T++W APM+ R + + +Y +GG+H G ++ V
Sbjct: 457 --DTFQNELMCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLS 514
Query: 441 -ERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEW 497
E Y P D+W +A ML + VGVAV +Y VGG+ NR + + Y PE++EW
Sbjct: 515 CEYYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW 574
Query: 498 RMITAMNTIRSGAGVCVL 515
+ + G C L
Sbjct: 575 HKVFDLPESLGGIRACTL 592
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 234 bits (596), Expect = 2e-61
Identities = 155/574 (27%), Positives = 260/574 (45%), Gaps = 18/574 (3%)
Query: 45 SQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSS 104
S T +T H+ ++LRL LCDVTL D F H+V++AS+S
Sbjct: 60 SSKAGPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTLMPGDTDDA---FPVHRVMMASAS 116
Query: 105 PVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQI 164
FKAMFT G++EQ + + + G+ + ++I+F YTA +S+ + + A QI
Sbjct: 117 DYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQI 176
Query: 165 DSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLS 224
V+ C FL+ + N + + A E+ + ++ +F + EF L
Sbjct: 177 LPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLKLP 236
Query: 225 HCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQ 284
+L ++S + L E E+F A W++ + E R + L++ +R +TP L
Sbjct: 237 FERLAFVLSSNSLKHCTELELFKATCRWLRLE-EPRMDFAAKLMKNIRFPLMTPQELINY 295
Query: 285 LQKCEILQSDSRCKDYLVKI--FEELTLHKPTQVMPCRAPKVGRL-IYTAGGYFRQSL-- 339
+Q + +++D+ C + L++ ++ + +P A + + T GG RQ L
Sbjct: 296 VQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDTTHLVTLGGVLRQQLVV 355
Query: 340 -SYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNN-SPDGNTDSSALDCYN 397
L Y+ W LA + PR V+G LY VGG++N G T + ++
Sbjct: 356 SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFD 415
Query: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
P N+W A ++ R + + G++YAVGG + +VE Y P +EW VA M
Sbjct: 416 PRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMS 475
Query: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHN 517
G V ++Y GG C+ P+ ++W M T+R +C +
Sbjct: 476 EPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGE 535
Query: 518 CIYAAG-----GYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGY 572
+Y G G D + S E Y + WT +A M +S +G+ V + +IYV+GGY
Sbjct: 536 RLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGY 595
Query: 573 --DGHTFLDSVECYDPDTDTWSEVTRMTSGRSGV 604
+ ++ V+ YDPD D W +V + G+
Sbjct: 596 SWNNRCMVEIVQKYDPDKDEWHKVFDLPESLGGI 629
Score = 100 bits (248), Expect = 5e-21
Identities = 62/196 (31%), Positives = 94/196 (47%), Gaps = 12/196 (6%)
Query: 328 IYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDG 386
+Y GG L +E YNP W +A + P G AG V GG++Y GG +
Sbjct: 443 LYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITH---- 498
Query: 387 NTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSH--GCIHHNSV---E 441
+T L C++P T++W APM+ R + + +Y +GG+H G ++ V E
Sbjct: 499 DTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCE 558
Query: 442 RYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEWRM 499
Y P D+W +A ML + VGVAV +Y VGG+ NR + + Y P+++EW
Sbjct: 559 YYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEWHK 618
Query: 500 ITAMNTIRSGAGVCVL 515
+ + G C L
Sbjct: 619 VFDLPESLGGIRACTL 634
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 233 bits (595), Expect = 3e-61
Identities = 162/545 (29%), Positives = 259/545 (47%), Gaps = 27/545 (4%)
Query: 67 MNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIE 126
+N LR DVTL A F H+ VLA+SS F+AMF++GLRE + V+ +
Sbjct: 36 LNTLRKHCMFTDVTLW-----AGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQ 90
Query: 127 -GIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
+HP+V+E L++FAY++ I++ E+ ++ M Q V A ++FL + L PSN +
Sbjct: 91 DNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLFPSNCL 150
Query: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
G+ ++ C L++ + +HF V + E+F +LS L+ LIS D+L E V
Sbjct: 151 GMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDLISSDELETEDERVV 210
Query: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCK---DYLV 302
F A + WVK+D E R+ ++ LLR+VR L + LQ + +L +D R K D +
Sbjct: 211 FEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLMADERTKLIMDEAL 270
Query: 303 KIFEELTLHKPTQVMPCRAP-KVGRLIYTAGGY-FRQSLSYLEAYNPSDGTWLRLADLQV 360
+ + + PC P K G + GG F Y + + + ADL
Sbjct: 271 RCKTRILQNDGVVTSPCARPRKAGHTLLILGGQTFMCDKIYQVDHKAKE--IIPKADLPS 328
Query: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
PR + +G +Y GGR + N S + Y+ + +WS APM + R G
Sbjct: 329 PRKEFSASAIGCKVYVTGGRGSE---NGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAE 385
Query: 421 IDGHIYAVGG---------SHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
++ +Y VGG + + VE+Y+P ++W +VAP+ V
Sbjct: 386 LENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLK 445
Query: 472 LYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ 530
L+ GG + ++ +CY P N W + VL + I+ GG D +
Sbjct: 446 LFVFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGG-DTEFT 504
Query: 531 LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDT 590
S R+D ET WT + M +R + ++YV+GGY G +++CYDP +DT
Sbjct: 505 AASAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDT 564
Query: 591 WSEVT 595
W+ +T
Sbjct: 565 WNCIT 569
Score = 74.3 bits (181), Expect = 3e-13
Identities = 46/166 (27%), Positives = 72/166 (43%), Gaps = 4/166 (2%)
Query: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
SL +E Y+P W+ +A L+ S A L+ GG + D S + CY+
Sbjct: 410 SLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDM---VSKVQCYD 466
Query: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
P N+W+ A P V+ I+ +GG S R++ E ++W + M
Sbjct: 467 PSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTE-FTAASAYRFDCETNQWTRIGDMT 525
Query: 458 TRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAM 503
+R+ LY VGG+ GT R + +CY P + W IT +
Sbjct: 526 AKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTV 571
Score = 40.0 bits (92), Expect = 0.006
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 10/98 (10%)
Query: 519 IYAAGGYDGQDQLNS-VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDG--- 574
+Y GG ++ ++ V YD E W+ APM R G + +YV+GG+
Sbjct: 342 VYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAG 401
Query: 575 ------HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
L VE YDP + W V + G S V
Sbjct: 402 VFPASPSVSLKQVEKYDPGANKWMMVAPLRDGVSNAAV 439
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 220 bits (561), Expect = 3e-57
Identities = 165/574 (28%), Positives = 259/574 (45%), Gaps = 43/574 (7%)
Query: 48 GNRTFSYTLED--HTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSP 105
G + Y +D H L D+TLQ F H+ VLA+ S
Sbjct: 5 GQEDYIYLFKDSTHPVDFLDAFRTFYLDGLFTDITLQCP----SGIIFHCHRAVLAACSN 60
Query: 106 VFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQID 165
FKAMFT ++E+ + + GIH ++E L+ +AYT+ I + ++ V ++ A + Q
Sbjct: 61 YFKAMFTADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFL 120
Query: 166 SVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSH 225
SV +AC FLV+ LD N IG+ +FAE C EL + +R + F EV +QEEF +S
Sbjct: 121 SVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEVWQQEEFLEISL 180
Query: 226 CQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQL 285
+ + ++SR +L+V E + I W +D E R + LL + + P +L+ L
Sbjct: 181 EKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYINI-DIDPVYLKTAL 239
Query: 286 ---QKCEILQSDSRCKDY--LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLS 340
+ C + ++ R Y L + +E++ + T M Y GGY+ LS
Sbjct: 240 GLQRSCLLTENKIRSLIYNALNPMHKEIS-QRSTATM-----------YIIGGYYWHPLS 287
Query: 341 YLEAYNPSDGTWLRLADL-QVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALD---CY 396
+ ++P W++ A++ R +G +Y GG + ALD Y
Sbjct: 288 EVHIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTD-----NIEALDTVWIY 342
Query: 397 NPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPM 456
N +++W+ PM R + G +YA+GG E Y+P +++W +A M
Sbjct: 343 NSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANM 402
Query: 457 LTRRIGVGVAVLNRLLYAVG---GFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVC 513
+ VL+ ++Y +G G+ G+ + + Y + NEW +IT+ G
Sbjct: 403 IKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSV 462
Query: 514 VLHNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG-- 571
N +Y GG Q E YD E W +APM RR G + G IYV GG
Sbjct: 463 PFENKLYLVGG-----QTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYS 517
Query: 572 YDGHTFLDSVECYDPDTDTWSEVTRMTSGRSGVG 605
Y T+L S+E YDPD + W V + S G
Sbjct: 518 YSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHG 551
Score = 87.0 bits (214), Expect = 5e-17
Identities = 55/198 (27%), Positives = 92/198 (46%), Gaps = 10/198 (5%)
Query: 321 APKVGRLIYTAGGYFRQS-LSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGG 379
A +G +Y GGY + + E Y+P W+ +A++ CV+ ++Y +GG
Sbjct: 364 AVTLGGCVYALGGYRKGAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGG 423
Query: 380 RNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNS 439
G+ + YN N+WS P + + +Y VGG
Sbjct: 424 HCGYR-GSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQT-----TI 477
Query: 440 VERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTNR--LNSAECYYPERNEW 497
E Y+PE++EW +APM+ RR+ G ++N +Y GG+ + L S E Y P+ N+W
Sbjct: 478 TECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKW 537
Query: 498 RMITAM-NTIRSGAGVCV 514
++ + + +RS VCV
Sbjct: 538 EIVGNLPSAMRSHGCVCV 555
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 218 bits (556), Expect = 1e-56
Identities = 163/560 (29%), Positives = 255/560 (45%), Gaps = 27/560 (4%)
Query: 48 GNRTFSYTL-EDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPV 106
G+ F ++ H + I NE R S+ DV + V+ ++ P H+ VL++ S
Sbjct: 36 GHEFFDFSSGSSHAENILQIFNEFRDSRLFTDVIICVEGKEFPC-----HRAVLSACSSY 90
Query: 107 FKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDS 166
F+AMF N RE +V I GI + ME +++ YT + + + V ++ + ++QI
Sbjct: 91 FRAMFCNDHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISV 150
Query: 167 VVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHC 226
+ AC+ FL +QLDP N +GI FA+ L + + + F +V++ EEF L
Sbjct: 151 LRDACAKFLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKD 210
Query: 227 QLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQ 286
+L+ I D+L + E VF A + WV + RR + LL VR L PN+ ++
Sbjct: 211 ELIDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVE 270
Query: 287 KCEILQSDSRCKDYLVKIFEELTLHK---PTQVMPCRAPKVGRLIYTAGGYFRQ---SLS 340
+++Q+ C L + L + P R+ +I GG R +L
Sbjct: 271 VDQLIQNSPECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLP 330
Query: 341 YLEAYNPSDGTWLRLADL-QVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPM 399
Y E Y+P G W LA L + +S A C + + GGR NS D + YN
Sbjct: 331 YTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSRD-------VWIYNSQ 383
Query: 400 TNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTR 459
N W A ++ R R + V+ G +Y VGG G +SVE Y+ + W VAP+
Sbjct: 384 LNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEA 443
Query: 460 RIGVGV-AVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNC 518
V + + +L GG D + + Y PE N W + A+ + L+N
Sbjct: 444 VSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRAAIPIAKRCITAVSLNNL 503
Query: 519 IYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGG-YDGHTF 577
IY AGG ++ YD + W V R+ G++V G+IY+LGG +
Sbjct: 504 IYVAGGL-----TKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRENGEA 558
Query: 578 LDSVECYDPDTDTWSEVTRM 597
D++ CYDP T + V M
Sbjct: 559 TDTILCYDPATSIITGVAAM 578
Score = 73.9 bits (180), Expect = 4e-13
Identities = 48/135 (35%), Positives = 67/135 (49%), Gaps = 12/135 (8%)
Query: 475 VGGFDGTNRLNSAECYYPERNEWRMITAMNTI-RSGAGVCVLHNCIYAAGGYDGQDQLNS 533
VGGF+ L ECY P EW+ + + +S VC L N I +GG ++NS
Sbjct: 324 VGGFN----LPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGG-----RINS 374
Query: 534 --VERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
V Y+ + W VA + R + V G++YV+GGYDG L SVECYD ++ W
Sbjct: 375 RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRW 434
Query: 592 SEVTRMTSGRSGVGV 606
+EV + S V
Sbjct: 435 TEVAPLKEAVSSPAV 449
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 217 bits (553), Expect = 2e-56
Identities = 159/590 (26%), Positives = 263/590 (44%), Gaps = 29/590 (4%)
Query: 43 TPSQHGNRTFSYTLEDHTKQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLAS 102
T ++G +++ H+ + LR QL DV L + + PA HKVVLA+
Sbjct: 29 TADKNGALKCTFSAPSHSTSLLQGLATLRAQGQLLDVVLTINREAFPA-----HKVVLAA 83
Query: 103 SSPVFKAMFTNGLREQGMEVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMY 162
S F+AMFT G+RE +V+ ++G+ + + +I+FAY+A +++ CV V+ AV
Sbjct: 84 CSDYFRAMFTGGMREASQDVIELKGVSARGLRHIIDFAYSAEVTLDLDCVQDVLGAAVFL 143
Query: 163 QIDSVVRACSDFLVQQLDPSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFN 222
Q+ VV C +FL + + I A L + + + HF ++A++E+F
Sbjct: 144 QMLPVVELCEEFLKAAMSVETCLNIGQMATTFSLASLRESVDAFTFRHFLQIAEEEDFLR 203
Query: 223 LSHCQLVTLISRDDLNVRCESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQ 282
L +LV + + L E ++F A + W+++D RR +L +R + + L
Sbjct: 204 LPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQHD-PARRPRASHVLCHIRFPLMQSSELV 262
Query: 283 MQLQKCEILQSDSRCKDYLVKI-------FEELTLHKPTQVMPCRAPKV---GRLIYTAG 332
+Q +I+ D C+ YL++ F + + P + P + G YT
Sbjct: 263 DSVQTLDIMVEDVLCRQYLLEAFNYQVLPFRQHEMQSPRTAVRSDVPSLVTFGGTPYTDS 322
Query: 333 GYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRN---NSPDGNTD 389
S Y + P + L +++V S V+ +Y GG++ S +G D
Sbjct: 323 DRSVSSKVY-QLPEPGARHFRELTEMEVGCSHTCVAVLDNFVYVAGGQHLQYRSGEGAVD 381
Query: 390 SSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDE 449
A Y+P N+W M R + + V+ G +YA GG + SVERY P R+E
Sbjct: 382 --ACYRYDPHLNRWLRLQAMQESRIQFQLNVLCGMVYATGGRNRAGSLASVERYCPRRNE 439
Query: 450 WHLVAPMLTRRIGVGVAVLNRLLYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRS 508
W + R G A LY GG+ + CY P ++W M+ R
Sbjct: 440 WGYACSLKRRTWGHAGAASGGRLYISGGYGISVEDKKALHCYDPVADQWEFKAPMSEPRV 499
Query: 509 GAGVCVLHNCIYAAGG----YDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQG 564
+ IYA GG D + +VE Y ET+ WT V+PM+ +S G + +
Sbjct: 500 LHAMVGAGGRIYALGGRMDHVDRCFDVLAVEYYVPETDQWTSVSPMRAGQSEAGCCLLER 559
Query: 565 RIYVLGGYDG--HTFLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
+IY++GGY+ + V+ Y+ DTD W +G+ A + P
Sbjct: 560 KIYIVGGYNWRLNNVTGIVQVYNTDTDEWERDLHFPESFAGIACAPVLLP 609
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 214 bits (545), Expect = 2e-55
Identities = 150/545 (27%), Positives = 252/545 (46%), Gaps = 27/545 (4%)
Query: 67 MNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLRE-QGMEVVSI 125
+N LR + DV L A F H+ VLA+ S F+AMF+ GL+E Q EV
Sbjct: 36 LNLLRQQRLFTDVLLH-----AGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFD 90
Query: 126 EGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAI 185
IHP+V+E L+++AY++ + + E+ ++ M + + AC++FL + L P+N +
Sbjct: 91 NSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCL 150
Query: 186 GIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESEV 245
G+ ++ C +L++ + +F + K E+F L +V L+S ++L E V
Sbjct: 151 GMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLV 210
Query: 246 FHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYL---V 302
+ + INW+ YD ++R Y+ LL+ VR L +L + E++ + K+ + +
Sbjct: 211 YESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAI 270
Query: 303 KIFEELTLHKPTQVMPCRAP-KVGRLIYTAGGY-FRQSLSYLEAYNPSDGTWLRLADLQV 360
+ ++ + C P K G ++ GG F YL + + AD+
Sbjct: 271 RCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKE--IIPKADIPS 328
Query: 361 PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV 420
PR + C +G +Y GGR + N S + Y+ + +WS APM V R G
Sbjct: 329 PRKEFSACAIGCKVYITGGRGSE---NGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAE 385
Query: 421 IDGHIYAVGG---SHGC------IHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRL 471
+ +Y VGG + GC + VE Y+P ++W +VAP+ V
Sbjct: 386 LKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLK 445
Query: 472 LYAVGGFD-GTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQ 530
L+A GG ++L +CY N W + VL N I+ GG D +
Sbjct: 446 LFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGG-DTEFS 504
Query: 531 LNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDT 590
S +++ ET WT V + +R + ++YV+GGY G +++CYDP D
Sbjct: 505 ACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDV 564
Query: 591 WSEVT 595
W+ +T
Sbjct: 565 WNSIT 569
Score = 66.6 bits (161), Expect = 6e-11
Identities = 45/169 (26%), Positives = 70/169 (41%), Gaps = 10/169 (5%)
Query: 338 SLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
SL +E Y+P+ W +A L+ S A L+A GG + S D + CY+
Sbjct: 410 SLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHD---KLPKVQCYD 466
Query: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGS---HGCIHHNSVERYEPERDEWHLVA 454
N+W+ A P V+ I+ +GG C S ++ E +W V
Sbjct: 467 QCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSAC----SAYKFNSETYQWTKVG 522
Query: 455 PMLTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAM 503
+ +R+ LY VGG+ G R + +CY P + W IT +
Sbjct: 523 DVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTV 571
Score = 41.6 bits (96), Expect = 0.002
Identities = 31/110 (28%), Positives = 45/110 (40%), Gaps = 10/110 (9%)
Query: 507 RSGAGVCVLHNCIYAAGGYDGQDQLNS-VERYDVETETWTFVAPMKHRRSALGITVHQGR 565
R C + +Y GG ++ ++ V YD E W+ APM R G +
Sbjct: 330 RKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHC 389
Query: 566 IYVLGGYDGHT---------FLDSVECYDPDTDTWSEVTRMTSGRSGVGV 606
+YV+GG+ T L VE YDP + W+ V + G S V
Sbjct: 390 LYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAV 439
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.136 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,431,188
Number of Sequences: 37866
Number of extensions: 1097296
Number of successful extensions: 3577
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 2074
Number of HSP's gapped (non-prelim): 412
length of query: 624
length of database: 18,247,518
effective HSP length: 108
effective length of query: 516
effective length of database: 14,157,990
effective search space: 7305522840
effective search space used: 7305522840
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.