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Search of human proteins with 21389315
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
(311 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21389315 solute carrier family 25 (mitochondrial carrier; cit... 632 0.0
gi|13449279 solute carrier family 25 (mitochondrial oxodicarboxy... 114 1e-25
gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens] 114 1e-25
gi|13899342 solute carrier [Homo sapiens] 112 4e-25
gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens] 111 7e-25
gi|116235462 solute carrier family 25, member 45 isoform a [Homo... 107 1e-23
gi|13259541 uncoupling protein 2 [Homo sapiens] 104 9e-23
gi|86198310 solute carrier family 25, member 29 [Homo sapiens] 103 2e-22
gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens] 102 6e-22
gi|21361103 solute carrier family 25, member 12 [Homo sapiens] 100 2e-21
gi|157388925 solute carrier family 25, member 38 [Homo sapiens] 100 2e-21
gi|11225256 uncoupling protein 1 [Homo sapiens] 99 4e-21
gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo s... 99 6e-21
gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo... 99 6e-21
gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens] 95 9e-20
gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo ... 93 3e-19
gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo s... 93 3e-19
gi|186928856 solute carrier family 25, member 19 [Homo sapiens] 91 1e-18
gi|186928860 solute carrier family 25, member 19 [Homo sapiens] 91 1e-18
gi|186928858 solute carrier family 25, member 19 [Homo sapiens] 91 1e-18
gi|48476342 solute carrier family 25, member 23 [Homo sapiens] 90 3e-18
gi|21314739 solute carrier family 25, member 32 [Homo sapiens] 88 8e-18
gi|27544933 solute carrier family 25, member 16 [Homo sapiens] 88 8e-18
gi|20149598 solute carrier family 25 (mitochondrial carrier; dic... 88 8e-18
gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens] 88 1e-17
gi|156071462 solute carrier family 25, member A6 [Homo sapiens] 88 1e-17
gi|156071459 solute carrier family 25, member 5 [Homo sapiens] 87 2e-17
gi|116235466 solute carrier family 25, member 45 isoform b [Homo... 86 5e-17
gi|58197562 solute carrier family 25, member 30 [Homo sapiens] 84 1e-16
gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens] 84 2e-16
>gi|21389315 solute carrier family 25 (mitochondrial carrier;
citrate transporter), member 1 precursor [Homo sapiens]
Length = 311
Score = 632 bits (1629), Expect = 0.0
Identities = 311/311 (100%), Positives = 311/311 (100%)
Query: 1 MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSH 60
MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSH
Sbjct: 1 MPAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSH 60
Query: 61 PPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLD 120
PPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLD
Sbjct: 61 PPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLD 120
Query: 121 STRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGT 180
STRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGT
Sbjct: 121 STRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGT 180
Query: 181 YQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTP 240
YQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTP
Sbjct: 181 YQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTP 240
Query: 241 LDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEV 300
LDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEV
Sbjct: 241 LDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEV 300
Query: 301 VKLLNKVWKTD 311
VKLLNKVWKTD
Sbjct: 301 VKLLNKVWKTD 311
>gi|13449279 solute carrier family 25 (mitochondrial
oxodicarboxylate carrier), member 21 [Homo sapiens]
Length = 299
Score = 114 bits (285), Expect = 1e-25
Identities = 87/301 (28%), Positives = 153/301 (50%), Gaps = 35/301 (11%)
Query: 27 KAILAGGLAGGIEICITFPTEYVKTQLQLDE-RSHPPRYRGIGDCVRQTVRSHGVLGLYR 85
+ I+AGG AG +EIC+ P + VKT+ Q+ + P Y+ + D R + G+ G Y+
Sbjct: 15 RQIVAGGSAGLVEICLMHPLDVVKTRFQIQRCATDPNSYKSLVDSFRMIFQMEGLFGFYK 74
Query: 86 GLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGL---LCGLGAGVAEAVVVVCP 142
G+ + PK AV+F FE + G + + L + GLG+G+ EA+VV P
Sbjct: 75 GILPPILAETPKRAVKFFTFE----QYKKLLGYVSLSPALTFAIAGLGSGLTEAIVVN-P 129
Query: 143 METIKVKFIHDQTS--PNPKYRGFFHGVREIVREQG--LKGTYQGLTATVLKQGSNQAIR 198
E +KV ++ + P G+ R+I++++G L+G +GLTAT+ + G +
Sbjct: 130 FEVVKVGLQANRNTFAEQPSTVGY---ARQIIKKEGWGLQGLNKGLTATLGRHGVFNMVY 186
Query: 199 FFVMTSLRNWYRGDNPNKPMN--PLIT-----GVFGAIAGAASVFGNTPLDVIKTRMQGL 251
F +++N P+N P++ G+ G ++G + N P DV K+R+QG
Sbjct: 187 FGFYYNVKNMI-------PVNKDPILEFWRKFGI-GLLSGTIASVINIPFDVAKSRIQGP 238
Query: 252 EAH----KYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKV 307
+ KYR + + ++EG+ A YKG +P++ R+ A++ ++Y+ L +
Sbjct: 239 QPVPGEIKYRTCFKTMATVYQEEGILALYKGLLPKIMRLGPGGAVMLLVYEYTYSWLQEN 298
Query: 308 W 308
W
Sbjct: 299 W 299
>gi|13375983 mitochondrial glutamate carrier 1 [Homo sapiens]
Length = 323
Score = 114 bits (284), Expect = 1e-25
Identities = 85/310 (27%), Positives = 145/310 (46%), Gaps = 41/310 (13%)
Query: 21 KLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGV 80
+++ P K ++ GG+AG I + FP + KT+LQ ++++ Y + DC+ +TVRS G
Sbjct: 5 QISLPAK-LINGGIAGLIGVTCVFPIDLAKTRLQ-NQQNGQRVYTSMSDCLIKTVRSEGY 62
Query: 81 LGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVV 140
G+YRG + L P+ A++ +F + + +L + +L G GAG + V+V
Sbjct: 63 FGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLTLLKEMLAGCGAGTCQ-VIVT 121
Query: 141 CPMETIKVKF----------------------------IHDQTSPNPKYRGFFHGVREIV 172
PME +K++ + +P P R+++
Sbjct: 122 TPMEMLKIQLQDAGRIAAQRKILAAQGQLSAQGGAQPSVEAPAAPRPTATQL---TRDLL 178
Query: 173 REQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPL-ITGVFGAIAG 231
R +G+ G Y+GL AT+L+ + F + +L R + K +P ++ + G +AG
Sbjct: 179 RSRGIAGLYKGLGATLLRDVPFSVVYFPLFANLNQLGRPASEEK--SPFYVSFLAGCVAG 236
Query: 232 AASVFGNTPLDVIKTRMQ----GLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVC 287
+A+ P DV+KTR+Q G+ Y DC +IL+ EG AF KG R +
Sbjct: 237 SAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKGAYCRALVIA 296
Query: 288 LDVAIVFVIY 297
I V+Y
Sbjct: 297 PLFGIAQVVY 306
Score = 36.2 bits (82), Expect = 0.038
Identities = 24/80 (30%), Positives = 36/80 (45%), Gaps = 5/80 (6%)
Query: 221 LITGVFGAIAGAASVFGNTPLDVIKTRMQGLE--AHKYRNTWDCGLQILKKEGLKAFYKG 278
LI G + G VF P+D+ KTR+Q + Y + DC ++ ++ EG Y+G
Sbjct: 12 LINGGIAGLIGVTCVF---PIDLAKTRLQNQQNGQRVYTSMSDCLIKTVRSEGYFGMYRG 68
Query: 279 TVPRLGRVCLDVAIVFVIYD 298
L V + AI D
Sbjct: 69 AAVNLTLVTPEKAIKLAAND 88
Score = 35.4 bits (80), Expect = 0.065
Identities = 29/96 (30%), Positives = 45/96 (46%), Gaps = 8/96 (8%)
Query: 28 AILAGGLAGGIEICITFPTEYVKTQLQLDERS-HPPRYRGIGDCVRQTVRSHGVLGLYRG 86
+ LAG +AG P + VKT+LQ +R + Y GI DC R+ +R G +G
Sbjct: 228 SFLAGCVAGSAAAVAVNPCDVVKTRLQSLQRGVNEDTYSGILDCARKILRHEGPSAFLKG 287
Query: 87 ------LSSLLYGSIPKAAVRFGMFEFLSNHMRDAQ 116
+ + L+G I + G+ E L ++D Q
Sbjct: 288 AYCRALVIAPLFG-IAQVVYFLGIAESLLGLLQDPQ 322
>gi|13899342 solute carrier [Homo sapiens]
Length = 315
Score = 112 bits (280), Expect = 4e-25
Identities = 88/287 (30%), Positives = 138/287 (48%), Gaps = 34/287 (11%)
Query: 22 LTHPGKAILA----GGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRS 77
+TH +I A GG+AG + + FP + KT+LQ + Y+G+ DC+ +T R+
Sbjct: 1 MTHQDLSITAKLINGGVAGLVGVTCVFPIDLAKTRLQ--NQHGKAMYKGMIDCLMKTARA 58
Query: 78 HGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAV 137
G G+YRG + L P+ A++ +F + + + + +L G GAG+ + V
Sbjct: 59 EGFFGMYRGAAVNLTLVTPEKAIKLAANDFFRRLLMEDGMQRNLKMEMLAGCGAGMCQ-V 117
Query: 138 VVVCPMETIKVKF-------IHDQTSPN--PKYRGFFHG-------------VREIVREQ 175
VV CPME +K++ +H Q S + R + G E++R Q
Sbjct: 118 VVTCPMEMLKIQLQDAGRLAVHHQGSASAPSTSRSYTTGSASTHRRPSATLIAWELLRTQ 177
Query: 176 GLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASV 235
GL G Y+GL AT+L+ I F + +L N + K + + V G +AG+ +
Sbjct: 178 GLAGLYRGLGATLLRDIPFSIIYFPLFANLNNLGFNELAGK-ASFAHSFVSGCVAGSIAA 236
Query: 236 FGNTPLDVIKTRMQ----GLEAHKYRNTWDCGLQILKKEGLKAFYKG 278
TPLDV+KTR+Q GL Y DC ++ +EG AF KG
Sbjct: 237 VAVTPLDVLKTRIQTLKKGLGEDMYSGITDCARKLWIQEGPSAFMKG 283
Score = 37.4 bits (85), Expect = 0.017
Identities = 26/85 (30%), Positives = 37/85 (43%), Gaps = 4/85 (4%)
Query: 221 LITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHK-YRNTWDCGLQILKKEGLKAFYKGT 279
LI G + G VF P+D+ KTR+Q Y+ DC ++ + EG Y+G
Sbjct: 12 LINGGVAGLVGVTCVF---PIDLAKTRLQNQHGKAMYKGMIDCLMKTARAEGFFGMYRGA 68
Query: 280 VPRLGRVCLDVAIVFVIYDEVVKLL 304
L V + AI D +LL
Sbjct: 69 AVNLTLVTPEKAIKLAANDFFRRLL 93
>gi|46397377 chromosome 14 open reading frame 68 [Homo sapiens]
Length = 308
Score = 111 bits (278), Expect = 7e-25
Identities = 92/307 (29%), Positives = 139/307 (45%), Gaps = 41/307 (13%)
Query: 30 LAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSS 89
+AG + G + + +P + VK ++Q + P+Y GI CVR T V G YRGLS
Sbjct: 4 VAGAIGGVCGVAVGYPLDTVKVRIQTE-----PKYTGIWHCVRDTYHRERVWGFYRGLSL 58
Query: 90 LLYGSIPKAAVRFGMFEFLSNHM-RDAQGRLDS--TRG--LLCGLGAGVAEAVVVVCPME 144
+ ++V FG + H+ R G D+ T+ L G +G+ V + P E
Sbjct: 59 PVCTVSLVSSVSFGTYRHCLAHICRLRYGNPDAKPTKADITLSGCASGLVR-VFLTSPTE 117
Query: 145 TIKVKFIHDQTS--------------------------PNPKYRGFFHGVREIVREQGLK 178
KV+ + QT P PKYRG H + + RE+GL
Sbjct: 118 VAKVR-LQTQTQAQKQQRRLSASGPLAVPPMCPVPPACPEPKYRGPLHCLATVAREEGLC 176
Query: 179 GTYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGN 238
G Y+G +A VL+ G + A F L W ++P P + V G AG +
Sbjct: 177 GLYKGSSALVLRDGHSFATYFLSYAVLCEWLSPAGHSRPDVPGVL-VAGGCAGVLAWAVA 235
Query: 239 TPLDVIKTRMQ--GLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVI 296
TP+DVIK+R+Q G +YR C + +++EG + +KG V R +VFV
Sbjct: 236 TPMDVIKSRLQADGQGQRRYRGLLHCMVTSVREEGPRVLFKGLVLNCCRAFPVNMVVFVA 295
Query: 297 YDEVVKL 303
Y+ V++L
Sbjct: 296 YEAVLRL 302
>gi|116235462 solute carrier family 25, member 45 isoform a [Homo
sapiens]
Length = 288
Score = 107 bits (268), Expect = 1e-23
Identities = 82/293 (27%), Positives = 134/293 (45%), Gaps = 24/293 (8%)
Query: 25 PGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLY 84
P + +AG ++G + + + P + VK +LQ YRGI DC+ + R +LG +
Sbjct: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTT-----YRGIVDCMVKIYRHESLLGFF 56
Query: 85 RGLSSLLYGSIPKAAVRFGMFE------FLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVV 138
+G+S + +V FG++ ++H L G G +A
Sbjct: 57 KGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYC 116
Query: 139 VVCPMETIKVKFIHDQT-------SPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQ 191
+ P + IKV+ + +QT SP P+Y+G H I RE+G +G ++G A L+
Sbjct: 117 LA-PFDLIKVR-LQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRD 174
Query: 192 GSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQ-- 249
I F L Y + N ++ V G AG AS TPLD+IK+RMQ
Sbjct: 175 TPTVGIYFITYEGLCRQYTPEGQNPSSATVL--VAGGFAGIASWVAATPLDMIKSRMQMD 232
Query: 250 GLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVK 302
GL Y+ DC + +++EGL F++G R A+ F+ Y+ +++
Sbjct: 233 GLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLR 285
Score = 57.4 bits (137), Expect = 2e-08
Identities = 48/186 (25%), Positives = 75/186 (40%), Gaps = 8/186 (4%)
Query: 30 LAGGLAGGIEICITFPTEYVKTQLQLDER------SHPPRYRGIGDCVRQTVRSHGVLGL 83
LAG G ++ P + +K +LQ S PPRY+G C R G GL
Sbjct: 104 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 163
Query: 84 YRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPM 143
+RG +L P + F +E L S L+ G AG+A + V P+
Sbjct: 164 FRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIA-SWVAATPL 222
Query: 144 ETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMT 203
+ IK + D Y+G + +R++GL ++G+T + A+ F
Sbjct: 223 DMIKSRMQMDGLR-RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 281
Query: 204 SLRNWY 209
L W+
Sbjct: 282 YLLRWW 287
Score = 40.8 bits (94), Expect = 0.002
Identities = 24/85 (28%), Positives = 42/85 (49%), Gaps = 2/85 (2%)
Query: 220 PLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGT 279
P+ V G I+GA + P D +K R+Q YR DC ++I + E L F+KG
Sbjct: 2 PVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTT--YRGIVDCMVKIYRHESLLGFFKGM 59
Query: 280 VPRLGRVCLDVAIVFVIYDEVVKLL 304
+ + + +++F +Y + +L
Sbjct: 60 SFPIASIAVVNSVLFGVYSNTLLVL 84
>gi|13259541 uncoupling protein 2 [Homo sapiens]
Length = 309
Score = 104 bits (260), Expect = 9e-23
Identities = 79/284 (27%), Positives = 127/284 (44%), Gaps = 12/284 (4%)
Query: 30 LAGGLAGGIEICITFPTEYVKTQLQLDERSHPP-------RYRGIGDCVRQTVRSHGVLG 82
L G A I ITFP + K +LQ+ S P +YRG+ + VR+ G
Sbjct: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77
Query: 83 LYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCP 142
LY GL + L + A+VR G+++ + LL G G A AV V P
Sbjct: 78 LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTG-ALAVAVAQP 136
Query: 143 METIKVKF-IHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFV 201
+ +KV+F + +Y+ + + I RE+G +G ++G + V +
Sbjct: 137 TDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVT 196
Query: 202 MTSLRNWYRGDNPNKPMNPL-ITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTW 260
+++ N P T FGA G + +P+DV+KTR +Y +
Sbjct: 197 YDLIKDALLKANLMTDDLPCHFTSAFGA--GFCTTVIASPVDVVKTRYMNSALGQYSSAG 254
Query: 261 DCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLL 304
C L +L+KEG +AFYKG +P R+ ++FV Y+++ + L
Sbjct: 255 HCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYEQLKRAL 298
Score = 69.3 bits (168), Expect = 4e-12
Identities = 51/191 (26%), Positives = 88/191 (46%), Gaps = 15/191 (7%)
Query: 129 LGAGVAEAV--VVVCPMETIKVKFIHDQTSPNP-------KYRGFFHGVREIVREQGLKG 179
LGAG A + ++ P++T KV+ S P +YRG + +VR +G +
Sbjct: 18 LGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMVRTEGPRS 77
Query: 180 TYQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNT 239
Y GL A + +Q S ++R + S++ +Y + + + + G+ GA +V
Sbjct: 78 LYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLA--GSTTGALAVAVAQ 135
Query: 240 PLDVIKTRMQGLE----AHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFV 295
P DV+K R Q +Y++T + I ++EG + +KGT P + R + V
Sbjct: 136 PTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELV 195
Query: 296 IYDEVVKLLNK 306
YD + L K
Sbjct: 196 TYDLIKDALLK 206
Score = 50.8 bits (120), Expect = 1e-06
Identities = 38/183 (20%), Positives = 77/183 (42%), Gaps = 6/183 (3%)
Query: 26 GKAILAGGLAGGIEICITFPTEYVKTQLQLDERS-HPPRYRGIGDCVRQTVRSHGVLGLY 84
G +LAG G + + + PT+ VK + Q R+ RY+ + + R G GL+
Sbjct: 117 GSRLLAGSTTGALAVAVAQPTDVVKVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLW 176
Query: 85 RGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTR-GLLCGLGAGVAEAVVVVCPM 143
+G S + + ++ + + + A D GAG V+ P+
Sbjct: 177 KGTSPNVARNAIVNCAELVTYDLIKDALLKANLMTDDLPCHFTSAFGAGFC-TTVIASPV 235
Query: 144 ETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMT 203
+ +K ++++ S +Y H +++++G + Y+G + L+ GS + F
Sbjct: 236 DVVKTRYMN---SALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRLGSWNVVMFVTYE 292
Query: 204 SLR 206
L+
Sbjct: 293 QLK 295
>gi|86198310 solute carrier family 25, member 29 [Homo sapiens]
Length = 303
Score = 103 bits (257), Expect = 2e-22
Identities = 78/258 (30%), Positives = 125/258 (48%), Gaps = 13/258 (5%)
Query: 31 AGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSL 90
AGG+AG + + P + VK +LQ+ + P+YRG C + ++ VLGLY+GL S
Sbjct: 10 AGGVAG---VLVGHPFDTVKVRLQV-QSVEKPQYRGTLHCFKSIIKQESVLGLYKGLGSP 65
Query: 91 LYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIKVKF 150
L G A+ FG+ N +R A G L G AG + V+ CPME K +
Sbjct: 66 LMGLTFINALVFGV---QGNTLR-ALGHDSPLNQFLAGAAAGAIQC-VICCPMELAKTRL 120
Query: 151 IHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYR 210
P Y+G + +I +GL+G +G+ +T+L++ + + F +L
Sbjct: 121 QLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTRALG 180
Query: 211 GDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQ--GLE-AHKYRNTWDCGLQIL 267
+ ++ + P + + G +G S P+DV+K+R+Q GL A +YR DC Q
Sbjct: 181 CEPGDRLLVPKLL-LAGGTSGIVSWLSTYPVDVVKSRLQADGLRGAPRYRGILDCVHQSY 239
Query: 268 KKEGLKAFYKGTVPRLGR 285
+ EG + F +G L R
Sbjct: 240 RAEGWRVFTRGLASTLLR 257
Score = 78.2 bits (191), Expect = 9e-15
Identities = 56/189 (29%), Positives = 89/189 (47%), Gaps = 2/189 (1%)
Query: 25 PGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLY 84
P LAG AG I+ I P E KT+LQL + Y+G DC+ Q G+ G+
Sbjct: 92 PLNQFLAGAAAGAIQCVICCPMELAKTRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVN 151
Query: 85 RGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQG-RLDSTRGLLCGLGAGVAEAVVVVCPM 143
RG+ S L P V F ++ L+ + G RL + LL G +G+ + + P+
Sbjct: 152 RGMVSTLLRETPSFGVYFLTYDALTRALGCEPGDRLLVPKLLLAGGTSGIV-SWLSTYPV 210
Query: 144 ETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMT 203
+ +K + D P+YRG V + R +G + +GL +T+L+ A F +T
Sbjct: 211 DVVKSRLQADGLRGAPRYRGILDCVHQSYRAEGWRVFTRGLASTLLRAFPVNAATFATVT 270
Query: 204 SLRNWYRGD 212
+ + RG+
Sbjct: 271 VVLTYARGE 279
Score = 76.3 bits (186), Expect = 3e-14
Identities = 56/182 (30%), Positives = 90/182 (49%), Gaps = 11/182 (6%)
Query: 126 LCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLT 185
L G GVA V+V P +T+KV+ + Q+ P+YRG H + I++++ + G Y+GL
Sbjct: 6 LAGCAGGVA-GVLVGHPFDTVKVR-LQVQSVEKPQYRGTLHCFKSIIKQESVLGLYKGLG 63
Query: 186 ATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIK 245
+ ++ A+ F V N R + P+N + G A AGA P+++ K
Sbjct: 64 SPLMGLTFINALVFGVQG---NTLRALGHDSPLNQFLAG---AAAGAIQCVICCPMELAK 117
Query: 246 TRMQGLEA---HKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVK 302
TR+Q +A Y+ + DC QI EGL+ +G V L R + F+ YD + +
Sbjct: 118 TRLQLQDAGPARTYKGSLDCLAQIYGHEGLRGVNRGMVSTLLRETPSFGVYFLTYDALTR 177
Query: 303 LL 304
L
Sbjct: 178 AL 179
>gi|4557403 carnitine/acylcarnitine translocase [Homo sapiens]
Length = 301
Score = 102 bits (253), Expect = 6e-22
Identities = 87/296 (29%), Positives = 136/296 (45%), Gaps = 17/296 (5%)
Query: 25 PGKAILAGGLAGGIEICITFPTEYVKTQLQLDERS---HPPRYRGIGDCVRQTVRSHGVL 81
P K +LAGG G + + P + VK +LQ S PP Y G DC R+T+ G+
Sbjct: 10 PLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRKTLFREGIT 69
Query: 82 GLYRGLSSLLYGSIPKAAVRFGMF----EFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAV 137
GLYRG+++ + G P AV F F + H D L + G+ +GV
Sbjct: 70 GLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQKHPEDV---LSYPQLFAAGMLSGVF-TT 125
Query: 138 VVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAI 197
++ P E IK +S KY G +++ +E G++G Y+G T+++ +
Sbjct: 126 GIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIRGIYKGTVLTLMRDVPASGM 185
Query: 198 RFFVMTSLRNWY--RGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHK 255
F L+N + G ++ P I V G IAG + P DV+K+R Q K
Sbjct: 186 YFMTYEWLKNIFTPEGKRVSELSAPRIL-VAGGIAGIFNWAVAIPPDVLKSRFQTAPPGK 244
Query: 256 YRNTW-DCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKT 310
Y N + D ++++ EG+ + YKG + R A F+ ++ +K LN W T
Sbjct: 245 YPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAACFLGFEVAMKFLN--WAT 298
Score = 76.6 bits (187), Expect = 3e-14
Identities = 57/194 (29%), Positives = 94/194 (48%), Gaps = 12/194 (6%)
Query: 22 LTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVL 81
L++P + AG L+G I P E +K LQ+ S +Y G DC ++ + G+
Sbjct: 108 LSYP-QLFAAGMLSGVFTTGIMTPGERIKCLLQIQASSGESKYTGTLDCAKKLYQEFGIR 166
Query: 82 GLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGR---LDSTRGLLCGLGAGVAEAVV 138
G+Y+G L +P + + F +E+L N R L + R L+ G AG+ V
Sbjct: 167 GIYKGTVLTLMRDVPASGMYFMTYEWLKNIFTPEGKRVSELSAPRILVAGGIAGIFNWAV 226
Query: 139 VVCPMETIKVKFIHDQTSPNPKY-RGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQA- 196
+ P + +K +F QT+P KY GF +RE++R++G+ Y+G A +++ A
Sbjct: 227 AI-PPDVLKSRF---QTAPPGKYPNGFRDVLRELIRDEGVTSLYKGFNAVMIRAFPANAA 282
Query: 197 --IRFFVMTSLRNW 208
+ F V NW
Sbjct: 283 CFLGFEVAMKFLNW 296
Score = 43.1 bits (100), Expect = 3e-04
Identities = 31/101 (30%), Positives = 45/101 (44%), Gaps = 7/101 (6%)
Query: 212 DNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGL------EAHKYRNTWDCGLQ 265
D P KP++PL + G G VF PLD +K R+Q + Y T+DC +
Sbjct: 3 DQP-KPISPLKNLLAGGFGGVCLVFVGHPLDTVKVRLQTQPPSLPGQPPMYSGTFDCFRK 61
Query: 266 ILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNK 306
L +EG+ Y+G + V A+ F + KL K
Sbjct: 62 TLFREGITGLYRGMAAPIIGVTPMFAVCFFGFGLGKKLQQK 102
>gi|21361103 solute carrier family 25, member 12 [Homo sapiens]
Length = 678
Score = 100 bits (249), Expect = 2e-21
Identities = 78/276 (28%), Positives = 131/276 (47%), Gaps = 18/276 (6%)
Query: 32 GGLAGGIEICITFPTEYVKTQLQLDERSHPP----RYRGIGDCVRQTVRSHGVLGLYRGL 87
G +AG + +P + VKT++Q S Y+ DC ++ +R G GLYRGL
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGL 392
Query: 88 SSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIK 147
L G P+ A++ + +F+ + G + +L G AG ++ V+ P+E +K
Sbjct: 393 IPQLIGVAPEKAIKLTVNDFVRDKFTRRDGSVPLPAEVLAGGCAGGSQ-VIFTNPLEIVK 451
Query: 148 VKF-IHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLR 206
++ + + + P+ ++R+ G+ G Y+G A L+ AI F V +
Sbjct: 452 IRLQVAGEITTGPRVSAL-----NVLRDLGIFGLYKGAKACFLRDIPFSAIYFPVYAHCK 506
Query: 207 NWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTW----DC 262
+N + L+ GA+AG + TP DVIKTR+Q + A + T+ DC
Sbjct: 507 LLLADENGHVGGLNLLAA--GAMAGVPAASLVTPADVIKTRLQ-VAARAGQTTYSGVIDC 563
Query: 263 GLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYD 298
+IL++EG AF+KGT R+ R + V Y+
Sbjct: 564 FRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYE 599
Score = 75.1 bits (183), Expect = 7e-14
Identities = 51/182 (28%), Positives = 81/182 (44%), Gaps = 7/182 (3%)
Query: 29 ILAGGLAGGIEICITFPTEYVKTQLQL-DERSHPPRYRGIGDCVRQTVRSHGVLGLYRGL 87
+LAGG AGG ++ T P E VK +LQ+ E + PR + +R G+ GLY+G
Sbjct: 430 VLAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSAL-----NVLRDLGIFGLYKGA 484
Query: 88 SSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIK 147
+ IP +A+ F ++ + D G + L G AGV A +V P + IK
Sbjct: 485 KACFLRDIPFSAIYFPVYAHCKLLLADENGHVGGLNLLAAGAMAGV-PAASLVTPADVIK 543
Query: 148 VKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRN 207
+ + Y G R+I+RE+G ++G A V + + L+
Sbjct: 544 TRLQVAARAGQTTYSGVIDCFRKILREEGPSAFWKGTAARVFRSSPQFGVTLVTYELLQR 603
Query: 208 WY 209
W+
Sbjct: 604 WF 605
Score = 50.8 bits (120), Expect = 1e-06
Identities = 27/81 (33%), Positives = 43/81 (53%), Gaps = 7/81 (8%)
Query: 227 GAIAGAASVFGNTPLDVIKTRMQGLEAH-------KYRNTWDCGLQILKKEGLKAFYKGT 279
G++AGA P+D++KTRMQ Y+N++DC ++L+ EG Y+G
Sbjct: 333 GSVAGAVGATAVYPIDLVKTRMQNQRGSGSVVGELMYKNSFDCFKKVLRYEGFFGLYRGL 392
Query: 280 VPRLGRVCLDVAIVFVIYDEV 300
+P+L V + AI + D V
Sbjct: 393 IPQLIGVAPEKAIKLTVNDFV 413
>gi|157388925 solute carrier family 25, member 38 [Homo sapiens]
Length = 304
Score = 100 bits (248), Expect = 2e-21
Identities = 76/282 (26%), Positives = 129/282 (45%), Gaps = 9/282 (3%)
Query: 22 LTHPG-KAILAGGLAGGIEICITFPTEYVKTQLQ-LDERSHPPRYRGIGDCVRQTVRSHG 79
+ HP KA L G ++G + P + +KT+LQ L H R G+ + + VR+
Sbjct: 23 MLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQTLQPSDHGSRRVGMLAVLLKVVRTES 82
Query: 80 VLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVV 139
+LGL++G+S + +P + FG L + + ++ G+G+ + A V
Sbjct: 83 LLGLWKGMSPSIVRCVPGVGIYFGTLYSLKQYFLRGHPPT-ALESVMLGVGSR-SVAGVC 140
Query: 140 VCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRF 199
+ P+ IK ++ S Y + +R I +G +G + GLTAT+L+ I
Sbjct: 141 MSPITVIKTRY----ESGKYGYESIYAALRSIYHSEGHRGLFSGLTATLLRDAPFSGIYL 196
Query: 200 FVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNT 259
+N D + + P+ G AG + P DVIKT MQ L K++
Sbjct: 197 MFYNQTKNIVPHDQVDATLIPITNFSCGIFAGILASLVTQPADVIKTHMQ-LYPLKFQWI 255
Query: 260 WDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVV 301
I K GL+ F++G +PR R L A+ + +Y+E++
Sbjct: 256 GQAVTLIFKDYGLRGFFQGGIPRALRRTLMAAMAWTVYEEMM 297
>gi|11225256 uncoupling protein 1 [Homo sapiens]
Length = 307
Score = 99.4 bits (246), Expect = 4e-21
Identities = 77/295 (26%), Positives = 138/295 (46%), Gaps = 10/295 (3%)
Query: 24 HP--GKAILAGGLAGGIEICITFPTEYVKTQLQLDER---SHPPRYRGIGDCVRQTVRSH 78
HP G + + G+A + ITFP + K +LQ+ S RY+G+ + V++
Sbjct: 10 HPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTE 69
Query: 79 GVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRG-LLCGLGAGVAEAV 137
G + LY GL + L I A++R G+++ + + + S +L GL G AV
Sbjct: 70 GRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTG-GVAV 128
Query: 138 VVVCPMETIKVKFIHDQT--SPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQ 195
+ P E +KV+ P+Y G ++ R I +GL G ++G T +++
Sbjct: 129 FIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIIN 188
Query: 196 AIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHK 255
++ + +N P V IAG + ++P+DV+KTR +
Sbjct: 189 CTELVTYDLMKEAFVKNNILADDVPCHL-VSALIAGFCATAMSSPVDVVKTRFINSPPGQ 247
Query: 256 YRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWKT 310
Y++ +C +++ EG AF+KG VP R+ I+FV ++++ + L+K +T
Sbjct: 248 YKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQT 302
Score = 63.2 bits (152), Expect = 3e-10
Identities = 53/198 (26%), Positives = 87/198 (43%), Gaps = 17/198 (8%)
Query: 17 SGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSH--PPRYRGIGDCVRQT 74
+GK G ILAG GG+ + I PTE VK +LQ H PRY G + R
Sbjct: 105 AGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRII 164
Query: 75 VRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFL------SNHMRDAQGRLDSTRGLLCG 128
+ G+ GL++G + L S+ ++ + +N + D D L+
Sbjct: 165 ATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILAD-----DVPCHLVSA 219
Query: 129 LGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATV 188
L AG A + P++ +K +FI+ SP +Y+ + ++ +G ++GL +
Sbjct: 220 LIAGFC-ATAMSSPVDVVKTRFIN---SPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSF 275
Query: 189 LKQGSNQAIRFFVMTSLR 206
L+ GS I F L+
Sbjct: 276 LRLGSWNVIMFVCFEQLK 293
>gi|7657581 solute carrier family 25, member 13 isoform 2 [Homo
sapiens]
Length = 675
Score = 98.6 bits (244), Expect = 6e-21
Identities = 78/277 (28%), Positives = 134/277 (48%), Gaps = 20/277 (7%)
Query: 32 GGLAGGIEICITFPTEYVKTQLQLDERSHPP-----RYRGIGDCVRQTVRSHGVLGLYRG 86
G +AG + +P + VKT++Q ++RS Y+ DC ++ +R G GLYRG
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQ-NQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRG 393
Query: 87 LSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETI 146
L L G P+ A++ + +F+ + G + +L G AG ++ V+ P+E +
Sbjct: 394 LLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQ-VIFTNPLEIV 452
Query: 147 KVKF-IHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSL 205
K++ + + + P+ +VR+ G G Y+G A L+ AI F +
Sbjct: 453 KIRLQVAGEITTGPRVSAL-----SVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHV 507
Query: 206 RNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTW----D 261
+ + N + ++P + GAIAG + TP DVIKTR+Q + A + T+ D
Sbjct: 508 KASFA--NEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQ-VAARAGQTTYSGVID 564
Query: 262 CGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYD 298
C +IL++EG KA +KG R+ R + + Y+
Sbjct: 565 CFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYE 601
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 7/182 (3%)
Query: 29 ILAGGLAGGIEICITFPTEYVKTQLQL-DERSHPPRYRGIGDCVRQTVRSHGVLGLYRGL 87
ILAGG AGG ++ T P E VK +LQ+ E + PR + VR G G+Y+G
Sbjct: 432 ILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALS-----VVRDLGFFGIYKGA 486
Query: 88 SSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIK 147
+ IP +A+ F + + + G++ LL G AG+ A +V P + IK
Sbjct: 487 KACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVT-PADVIK 545
Query: 148 VKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRN 207
+ + Y G R+I+RE+G K ++G A V + + L+
Sbjct: 546 TRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 605
Query: 208 WY 209
W+
Sbjct: 606 WF 607
Score = 55.1 bits (131), Expect = 8e-08
Identities = 27/84 (32%), Positives = 45/84 (53%)
Query: 25 PGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLY 84
PG +LAG +AG + P + +KT+LQ+ R+ Y G+ DC R+ +R G L+
Sbjct: 520 PGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALW 579
Query: 85 RGLSSLLYGSIPKAAVRFGMFEFL 108
+G + ++ S P+ V +E L
Sbjct: 580 KGAGARVFRSSPQFGVTLLTYELL 603
Score = 50.1 bits (118), Expect = 3e-06
Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 7/81 (8%)
Query: 227 GAIAGAASVFGNTPLDVIKTRMQGLEAH-------KYRNTWDCGLQILKKEGLKAFYKGT 279
G++AGA P+D++KTRMQ + Y+N++DC ++L+ EG Y+G
Sbjct: 335 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 394
Query: 280 VPRLGRVCLDVAIVFVIYDEV 300
+P+L V + AI + D V
Sbjct: 395 LPQLLGVAPEKAIKLTVNDFV 415
>gi|237649019 solute carrier family 25, member 13 isoform 1 [Homo
sapiens]
Length = 676
Score = 98.6 bits (244), Expect = 6e-21
Identities = 78/277 (28%), Positives = 134/277 (48%), Gaps = 20/277 (7%)
Query: 32 GGLAGGIEICITFPTEYVKTQLQLDERSHPP-----RYRGIGDCVRQTVRSHGVLGLYRG 86
G +AG + +P + VKT++Q ++RS Y+ DC ++ +R G GLYRG
Sbjct: 336 GSVAGAVGATAVYPIDLVKTRMQ-NQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRG 394
Query: 87 LSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETI 146
L L G P+ A++ + +F+ + G + +L G AG ++ V+ P+E +
Sbjct: 395 LLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLAAEILAGGCAGGSQ-VIFTNPLEIV 453
Query: 147 KVKF-IHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSL 205
K++ + + + P+ +VR+ G G Y+G A L+ AI F +
Sbjct: 454 KIRLQVAGEITTGPRVSAL-----SVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHV 508
Query: 206 RNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTW----D 261
+ + N + ++P + GAIAG + TP DVIKTR+Q + A + T+ D
Sbjct: 509 KASFA--NEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQ-VAARAGQTTYSGVID 565
Query: 262 CGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYD 298
C +IL++EG KA +KG R+ R + + Y+
Sbjct: 566 CFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYE 602
Score = 74.7 bits (182), Expect = 1e-13
Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 7/182 (3%)
Query: 29 ILAGGLAGGIEICITFPTEYVKTQLQL-DERSHPPRYRGIGDCVRQTVRSHGVLGLYRGL 87
ILAGG AGG ++ T P E VK +LQ+ E + PR + VR G G+Y+G
Sbjct: 433 ILAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALS-----VVRDLGFFGIYKGA 487
Query: 88 SSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIK 147
+ IP +A+ F + + + G++ LL G AG+ A +V P + IK
Sbjct: 488 KACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVT-PADVIK 546
Query: 148 VKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRN 207
+ + Y G R+I+RE+G K ++G A V + + L+
Sbjct: 547 TRLQVAARAGQTTYSGVIDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQR 606
Query: 208 WY 209
W+
Sbjct: 607 WF 608
Score = 55.1 bits (131), Expect = 8e-08
Identities = 27/84 (32%), Positives = 45/84 (53%)
Query: 25 PGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLY 84
PG +LAG +AG + P + +KT+LQ+ R+ Y G+ DC R+ +R G L+
Sbjct: 521 PGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVIDCFRKILREEGPKALW 580
Query: 85 RGLSSLLYGSIPKAAVRFGMFEFL 108
+G + ++ S P+ V +E L
Sbjct: 581 KGAGARVFRSSPQFGVTLLTYELL 604
Score = 50.1 bits (118), Expect = 3e-06
Identities = 27/81 (33%), Positives = 44/81 (54%), Gaps = 7/81 (8%)
Query: 227 GAIAGAASVFGNTPLDVIKTRMQGLEAH-------KYRNTWDCGLQILKKEGLKAFYKGT 279
G++AGA P+D++KTRMQ + Y+N++DC ++L+ EG Y+G
Sbjct: 336 GSVAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGL 395
Query: 280 VPRLGRVCLDVAIVFVIYDEV 300
+P+L V + AI + D V
Sbjct: 396 LPQLLGVAPEKAIKLTVNDFV 416
>gi|4507807 uncoupling protein 3 isoform UCP3L [Homo sapiens]
Length = 312
Score = 94.7 bits (234), Expect = 9e-20
Identities = 76/292 (26%), Positives = 133/292 (45%), Gaps = 19/292 (6%)
Query: 30 LAGGLAGGIEICITFPTEYVKTQLQLD------ERSHPPRYRGIGDCVRQTVRSHGVLGL 83
L G A +TFP + K +LQ+ + + +YRG+ + VR+ G
Sbjct: 18 LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77
Query: 84 YRGLSSLLYGSIPKAAVRFGMFEFLSN-HMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCP 142
Y GL + L + A++R G+++ + + T +L G G A AV P
Sbjct: 78 YNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTG-AMAVTCAQP 136
Query: 143 METIKVKF---IH-DQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQG---SNQ 195
+ +KV+F IH + + KY G R I RE+G++G ++G +++ +
Sbjct: 137 TDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAE 196
Query: 196 AIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHK 255
+ + ++ Y N P + FGA G + +P+DV+KTR +
Sbjct: 197 VVTYDILKEKLLDYHLLTDNFPCH--FVSAFGA--GFCATVVASPVDVVKTRYMNSPPGQ 252
Query: 256 YRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKV 307
Y + DC ++++ +EG AFYKG P R+ ++FV Y+++ + L KV
Sbjct: 253 YFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTYEQLKRALMKV 304
Score = 57.0 bits (136), Expect = 2e-08
Identities = 49/184 (26%), Positives = 82/184 (44%), Gaps = 11/184 (5%)
Query: 29 ILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPR----YRGIGDCVRQTVRSHGVLGLY 84
ILAG G + + PT+ VK + Q P R Y G D R R GV GL+
Sbjct: 120 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW 179
Query: 85 RG-LSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDS-TRGLLCGLGAGVAEAVVVVCP 142
+G L +++ +I A ++ L + D D+ + GAG A VV P
Sbjct: 180 KGTLPNIMRNAIVNCA-EVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFC-ATVVASP 237
Query: 143 METIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVM 202
++ +K ++++ SP +Y + ++V ++G Y+G T + L+ GS + F
Sbjct: 238 VDVVKTRYMN---SPPGQYFSPLDCMIKMVAQEGPTAFYKGFTPSFLRLGSWNVVMFVTY 294
Query: 203 TSLR 206
L+
Sbjct: 295 EQLK 298
>gi|148491091 solute carrier family 25 member 24 isoform 1 [Homo
sapiens]
Length = 477
Score = 92.8 bits (229), Expect = 3e-19
Identities = 72/288 (25%), Positives = 132/288 (45%), Gaps = 11/288 (3%)
Query: 27 KAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRG 86
+ +LAGG+AG + T P + +K +Q+ S + G RQ V+ G+ L+RG
Sbjct: 196 RQLLAGGIAGAVSRTSTAPLDRLKIMMQV-HGSKSDKMNIFGG-FRQMVKEGGIRSLWRG 253
Query: 87 LSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETI 146
+ + P+ AV+F +E + + ++ + + G AG A A + PME +
Sbjct: 254 NGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAG-ATAQTFIYPMEVM 312
Query: 147 KVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLR 206
K + +T +Y G + ++I++ +GL Y+G +L I V L+
Sbjct: 313 KTRLAVGKTG---QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLK 369
Query: 207 NWYRGDNPNKPMNPLITGVFG--AIAGAASVFGNTPLDVIKTRMQG---LEAHKYRNTWD 261
+++ + +NP + + G A++ + PL +++TRMQ LE N
Sbjct: 370 SYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVG 429
Query: 262 CGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWK 309
+I+ KEG+ Y+G P +V V I +V+Y+ + + L K
Sbjct: 430 LFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 477
Score = 65.1 bits (157), Expect = 8e-11
Identities = 48/200 (24%), Positives = 90/200 (45%), Gaps = 18/200 (9%)
Query: 19 KAKLTHPGKAI------LAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVR 72
K LT G+ I ++G +AG +P E +KT+L + + +Y GI DC +
Sbjct: 276 KKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTG---QYSGIYDCAK 332
Query: 73 QTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAG 132
+ ++ G+ Y+G L G IP A + ++E L ++ D + G++ LG G
Sbjct: 333 KILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCG 392
Query: 133 VAEAV---VVVCPMETIKVKFIHD---QTSPNPKYRGFFHGVREIVREQGLKGTYQGLTA 186
+ + P+ ++ + + SP G F R I+ ++G+ G Y+G+T
Sbjct: 393 ALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLF---RRIISKEGIPGLYRGITP 449
Query: 187 TVLKQGSNQAIRFFVMTSLR 206
+K I + V +++
Sbjct: 450 NFMKVLPAVGISYVVYENMK 469
>gi|47458041 solute carrier family 25 member 24 isoform 2 [Homo
sapiens]
Length = 458
Score = 92.8 bits (229), Expect = 3e-19
Identities = 72/288 (25%), Positives = 132/288 (45%), Gaps = 11/288 (3%)
Query: 27 KAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRG 86
+ +LAGG+AG + T P + +K +Q+ S + G RQ V+ G+ L+RG
Sbjct: 177 RQLLAGGIAGAVSRTSTAPLDRLKIMMQV-HGSKSDKMNIFGG-FRQMVKEGGIRSLWRG 234
Query: 87 LSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETI 146
+ + P+ AV+F +E + + ++ + + G AG A A + PME +
Sbjct: 235 NGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKIGTFERFISGSMAG-ATAQTFIYPMEVM 293
Query: 147 KVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLR 206
K + +T +Y G + ++I++ +GL Y+G +L I V L+
Sbjct: 294 KTRLAVGKTG---QYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLK 350
Query: 207 NWYRGDNPNKPMNPLITGVFG--AIAGAASVFGNTPLDVIKTRMQG---LEAHKYRNTWD 261
+++ + +NP + + G A++ + PL +++TRMQ LE N
Sbjct: 351 SYWLDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVG 410
Query: 262 CGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLLNKVWK 309
+I+ KEG+ Y+G P +V V I +V+Y+ + + L K
Sbjct: 411 LFRRIISKEGIPGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVTQK 458
Score = 65.1 bits (157), Expect = 8e-11
Identities = 48/200 (24%), Positives = 90/200 (45%), Gaps = 18/200 (9%)
Query: 19 KAKLTHPGKAI------LAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVR 72
K LT G+ I ++G +AG +P E +KT+L + + +Y GI DC +
Sbjct: 257 KKLLTEEGQKIGTFERFISGSMAGATAQTFIYPMEVMKTRLAVGKTG---QYSGIYDCAK 313
Query: 73 QTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAG 132
+ ++ G+ Y+G L G IP A + ++E L ++ D + G++ LG G
Sbjct: 314 KILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCG 373
Query: 133 VAEAV---VVVCPMETIKVKFIHD---QTSPNPKYRGFFHGVREIVREQGLKGTYQGLTA 186
+ + P+ ++ + + SP G F R I+ ++G+ G Y+G+T
Sbjct: 374 ALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLF---RRIISKEGIPGLYRGITP 430
Query: 187 TVLKQGSNQAIRFFVMTSLR 206
+K I + V +++
Sbjct: 431 NFMKVLPAVGISYVVYENMK 450
>gi|186928856 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 90.9 bits (224), Expect = 1e-18
Identities = 79/289 (27%), Positives = 127/289 (43%), Gaps = 24/289 (8%)
Query: 30 LAGGLAGGIEICITFPTEYVKTQLQLDE----RSHPP-RYRGIGDCVRQTVRSHGVLGLY 84
+AG ++G + + P + +K + QL RS P +Y GI RQ ++ G +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 85 RGLSSLLYGSIPKAAVRFGMFEFLSN--HMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCP 142
+G SI AV+F FE L+ H + + +CG G A + V P
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCG-GLAACMATLTVHP 138
Query: 143 METIKVKFIHDQTSPNPK-YRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFV 201
++ ++ +F PK Y H V + R +G + Y+GL T++ ++F
Sbjct: 139 VDVLRTRFA---AQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195
Query: 202 MTSLRNWYRGDNP--NKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQ--GLE----- 252
+SL++ Y+ P K L + G+ AG S PLD+ K R+Q G E
Sbjct: 196 YSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAA 255
Query: 253 ---AHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYD 298
+Y+ DC Q+L+KEG F+KG P L + L +F Y+
Sbjct: 256 FGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 52.0 bits (123), Expect = 7e-07
Identities = 33/105 (31%), Positives = 48/105 (45%), Gaps = 9/105 (8%)
Query: 13 AAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPP-------RYR 65
A PA GK +L G AG I +T+P + K +LQ+ H RY+
Sbjct: 206 AIPAEGKKNENLQN--LLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYK 263
Query: 66 GIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSN 110
G+ DC +Q ++ G LG ++GLS L + F +EF N
Sbjct: 264 GLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFFCN 308
Score = 50.4 bits (119), Expect = 2e-06
Identities = 43/172 (25%), Positives = 75/172 (43%), Gaps = 8/172 (4%)
Query: 139 VVCPMETIKVKFI--HDQTS---PNPKYRGFFHGVREIVREQGLKGTYQG-LTATVLKQG 192
++ P + IK++F H++ S P+ KY G R+I++E+G ++G + A +L G
Sbjct: 32 LISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIG 91
Query: 193 SNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLE 252
A++F L + + V G +A + P+DV++TR
Sbjct: 92 YG-AVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQG 150
Query: 253 AHKYRNTWDCGLQIL-KKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKL 303
K NT + + + EG + FYKG P L + + F Y + L
Sbjct: 151 EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHL 202
>gi|186928860 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 90.9 bits (224), Expect = 1e-18
Identities = 79/289 (27%), Positives = 127/289 (43%), Gaps = 24/289 (8%)
Query: 30 LAGGLAGGIEICITFPTEYVKTQLQLDE----RSHPP-RYRGIGDCVRQTVRSHGVLGLY 84
+AG ++G + + P + +K + QL RS P +Y GI RQ ++ G +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 85 RGLSSLLYGSIPKAAVRFGMFEFLSN--HMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCP 142
+G SI AV+F FE L+ H + + +CG G A + V P
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCG-GLAACMATLTVHP 138
Query: 143 METIKVKFIHDQTSPNPK-YRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFV 201
++ ++ +F PK Y H V + R +G + Y+GL T++ ++F
Sbjct: 139 VDVLRTRFA---AQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195
Query: 202 MTSLRNWYRGDNP--NKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQ--GLE----- 252
+SL++ Y+ P K L + G+ AG S PLD+ K R+Q G E
Sbjct: 196 YSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAA 255
Query: 253 ---AHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYD 298
+Y+ DC Q+L+KEG F+KG P L + L +F Y+
Sbjct: 256 FGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 52.0 bits (123), Expect = 7e-07
Identities = 33/105 (31%), Positives = 48/105 (45%), Gaps = 9/105 (8%)
Query: 13 AAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPP-------RYR 65
A PA GK +L G AG I +T+P + K +LQ+ H RY+
Sbjct: 206 AIPAEGKKNENLQN--LLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYK 263
Query: 66 GIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSN 110
G+ DC +Q ++ G LG ++GLS L + F +EF N
Sbjct: 264 GLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFFCN 308
Score = 50.4 bits (119), Expect = 2e-06
Identities = 43/172 (25%), Positives = 75/172 (43%), Gaps = 8/172 (4%)
Query: 139 VVCPMETIKVKFI--HDQTS---PNPKYRGFFHGVREIVREQGLKGTYQG-LTATVLKQG 192
++ P + IK++F H++ S P+ KY G R+I++E+G ++G + A +L G
Sbjct: 32 LISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIG 91
Query: 193 SNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLE 252
A++F L + + V G +A + P+DV++TR
Sbjct: 92 YG-AVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQG 150
Query: 253 AHKYRNTWDCGLQIL-KKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKL 303
K NT + + + EG + FYKG P L + + F Y + L
Sbjct: 151 EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHL 202
>gi|186928858 solute carrier family 25, member 19 [Homo sapiens]
Length = 320
Score = 90.9 bits (224), Expect = 1e-18
Identities = 79/289 (27%), Positives = 127/289 (43%), Gaps = 24/289 (8%)
Query: 30 LAGGLAGGIEICITFPTEYVKTQLQLDE----RSHPP-RYRGIGDCVRQTVRSHGVLGLY 84
+AG ++G + + P + +K + QL RS P +Y GI RQ ++ G +
Sbjct: 20 VAGSVSGLVTRALISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFW 79
Query: 85 RGLSSLLYGSIPKAAVRFGMFEFLSN--HMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCP 142
+G SI AV+F FE L+ H + + +CG G A + V P
Sbjct: 80 KGHVPAQILSIGYGAVQFLSFEMLTELVHRGSVYDAREFSVHFVCG-GLAACMATLTVHP 138
Query: 143 METIKVKFIHDQTSPNPK-YRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFV 201
++ ++ +F PK Y H V + R +G + Y+GL T++ ++F
Sbjct: 139 VDVLRTRFA---AQGEPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSC 195
Query: 202 MTSLRNWYRGDNP--NKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQ--GLE----- 252
+SL++ Y+ P K L + G+ AG S PLD+ K R+Q G E
Sbjct: 196 YSSLKHLYKWAIPAEGKKNENLQNLLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAA 255
Query: 253 ---AHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYD 298
+Y+ DC Q+L+KEG F+KG P L + L +F Y+
Sbjct: 256 FGQVRRYKGLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYE 304
Score = 52.0 bits (123), Expect = 7e-07
Identities = 33/105 (31%), Positives = 48/105 (45%), Gaps = 9/105 (8%)
Query: 13 AAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPP-------RYR 65
A PA GK +L G AG I +T+P + K +LQ+ H RY+
Sbjct: 206 AIPAEGKKNENLQN--LLCGSGAGVISKTLTYPLDLFKKRLQVGGFEHARAAFGQVRRYK 263
Query: 66 GIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSN 110
G+ DC +Q ++ G LG ++GLS L + F +EF N
Sbjct: 264 GLMDCAKQVLQKEGALGFFKGLSPSLLKAALSTGFMFFSYEFFCN 308
Score = 50.4 bits (119), Expect = 2e-06
Identities = 43/172 (25%), Positives = 75/172 (43%), Gaps = 8/172 (4%)
Query: 139 VVCPMETIKVKFI--HDQTS---PNPKYRGFFHGVREIVREQGLKGTYQG-LTATVLKQG 192
++ P + IK++F H++ S P+ KY G R+I++E+G ++G + A +L G
Sbjct: 32 LISPFDVIKIRFQLQHERLSRSDPSAKYHGILQASRQILQEEGPTAFWKGHVPAQILSIG 91
Query: 193 SNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLE 252
A++F L + + V G +A + P+DV++TR
Sbjct: 92 YG-AVQFLSFEMLTELVHRGSVYDAREFSVHFVCGGLAACMATLTVHPVDVLRTRFAAQG 150
Query: 253 AHKYRNTWDCGLQIL-KKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKL 303
K NT + + + EG + FYKG P L + + F Y + L
Sbjct: 151 EPKVYNTLRHAVGTMYRSEGPQVFYKGLAPTLIAIFPYAGLQFSCYSSLKHL 202
>gi|48476342 solute carrier family 25, member 23 [Homo sapiens]
Length = 468
Score = 89.7 bits (221), Expect = 3e-18
Identities = 72/283 (25%), Positives = 128/283 (45%), Gaps = 11/283 (3%)
Query: 27 KAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRG 86
K ++AG +AG + T P + +K +Q+ S R +G +R V G+ L+RG
Sbjct: 187 KQLVAGAVAGAVSRTGTAPLDRLKVFMQV-HASKTNRLNILGG-LRSMVLEGGIRSLWRG 244
Query: 87 LSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETI 146
+ P++A++F +E + + Q L + G AG A A ++ PME +
Sbjct: 245 NGINVLKIAPESAIKFMAYEQIKRAILGQQETLHVQERFVAGSLAG-ATAQTIIYPMEVL 303
Query: 147 KVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLR 206
K + +T +Y+G R I+ +G + Y+G VL I V +L+
Sbjct: 304 KTRLTLRRTG---QYKGLLDCARRILEREGPRAFYRGYLPNVLGIIPYAGIDLAVYETLK 360
Query: 207 NWYRGDNPNKPMNP--LITGVFGAIAGAASVFGNTPLDVIKTRMQG---LEAHKYRNTWD 261
NW+ + +P L+ G I+ + PL +++TRMQ +E +
Sbjct: 361 NWWLQQYSHDSADPGILVLLACGTISSTCGQIASYPLALVRTRMQAQASIEGGPQLSMLG 420
Query: 262 CGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLL 304
IL +EG++ Y+G P +V V+I +V+Y+ + + L
Sbjct: 421 LLRHILSQEGMRGLYRGIAPNFMKVIPAVSISYVVYENMKQAL 463
Score = 67.4 bits (163), Expect = 2e-11
Identities = 44/192 (22%), Positives = 83/192 (43%), Gaps = 6/192 (3%)
Query: 18 GKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRS 77
G+ + H + +AG LAG I +P E +KT+L L +Y+G+ DC R+ +
Sbjct: 272 GQQETLHVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTG---QYKGLLDCARRILER 328
Query: 78 HGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAV 137
G YRG + G IP A + ++E L N + G+L L G +
Sbjct: 329 EGPRAFYRGYLPNVLGIIPYAGIDLAVYETLKNWWLQQYSHDSADPGILVLLACGTISST 388
Query: 138 ---VVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSN 194
+ P+ ++ + + +R I+ ++G++G Y+G+ +K
Sbjct: 389 CGQIASYPLALVRTRMQAQASIEGGPQLSMLGLLRHILSQEGMRGLYRGIAPNFMKVIPA 448
Query: 195 QAIRFFVMTSLR 206
+I + V +++
Sbjct: 449 VSISYVVYENMK 460
>gi|21314739 solute carrier family 25, member 32 [Homo sapiens]
Length = 315
Score = 88.2 bits (217), Expect = 8e-18
Identities = 75/289 (25%), Positives = 134/289 (46%), Gaps = 21/289 (7%)
Query: 30 LAGGLAGGIEICITF-PTEYVKTQLQL-DERSHPPRYRGIGDCVRQTVRSHGVLGLYRGL 87
L G++GG+ + P + VK + + D P+Y GI C+ + G+ GLY+G+
Sbjct: 26 LIAGVSGGVLSNLALHPLDLVKIRFAVSDGLELRPKYNGILHCLTTIWKLDGLRGLYQGV 85
Query: 88 SSLLYGSIPKAAVRFGMFEFLSNHMRDAQG-----RLDSTRGLLCGLGAGVAEAVVVVCP 142
+ ++G A + +G++ F N ++ + RL++T L+ AG A + + P
Sbjct: 86 TPNIWG----AGLSWGLYFFFYNAIKSYKTEGRAERLEATEYLVSAAEAG-AMTLCITNP 140
Query: 143 METIKVKFIHDQ----TSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIR 198
+ K + + SP+ +Y+G F + +I + +G++G Y+G + S+ A++
Sbjct: 141 LWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVKIYKYEGVRGLYKGFVPGLFGT-SHGALQ 199
Query: 199 FFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFG---NTPLDVIKTRMQGLEAHK 255
F L+ Y P L T + ++A + +F P V++ R+Q
Sbjct: 200 FMAYELLKLKYNQHINRLPEAQLSTVEYISVAALSKIFAVAATYPYQVVRARLQDQHMF- 258
Query: 256 YRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLL 304
Y D + +KEG+ FYKG P L RV I FV+Y+ V L
Sbjct: 259 YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACCITFVVYENVSHFL 307
Score = 52.4 bits (124), Expect = 5e-07
Identities = 47/199 (23%), Positives = 89/199 (44%), Gaps = 13/199 (6%)
Query: 18 GKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLD----ERSHPPRYRGIGDCVRQ 73
G+A+ + +++ AG + +CIT P KT+L L S +Y+G+ D + +
Sbjct: 113 GRAERLEATEYLVSAAEAGAMTLCITNPLWVTKTRLMLQYDAVVNSPHRQYKGMFDTLVK 172
Query: 74 TVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLD----STRGLLCGL 129
+ GV GLY+G L+G+ A++F +E L RL ST +
Sbjct: 173 IYKYEGVRGLYKGFVPGLFGT-SHGALQFMAYELLKLKYNQHINRLPEAQLSTVEYISVA 231
Query: 130 GAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVL 189
AV P + ++ + + DQ + Y G + + R++G+ G Y+G+ ++
Sbjct: 232 ALSKIFAVAATYPYQVVRAR-LQDQ---HMFYSGVIDVITKTWRKEGVGGFYKGIAPNLI 287
Query: 190 KQGSNQAIRFFVMTSLRNW 208
+ I F V ++ ++
Sbjct: 288 RVTPACCITFVVYENVSHF 306
Score = 39.3 bits (90), Expect = 0.005
Identities = 22/75 (29%), Positives = 40/75 (53%), Gaps = 4/75 (5%)
Query: 40 ICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAA 99
+ T+P + V+ +LQ D+ Y G+ D + +T R GV G Y+G++ L P
Sbjct: 239 VAATYPYQVVRARLQ-DQHMF---YSGVIDVITKTWRKEGVGGFYKGIAPNLIRVTPACC 294
Query: 100 VRFGMFEFLSNHMRD 114
+ F ++E +S+ + D
Sbjct: 295 ITFVVYENVSHFLLD 309
>gi|27544933 solute carrier family 25, member 16 [Homo sapiens]
Length = 332
Score = 88.2 bits (217), Expect = 8e-18
Identities = 87/319 (27%), Positives = 131/319 (41%), Gaps = 32/319 (10%)
Query: 2 PAPRAPRALAAAAPASGKAKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERSHP 61
P P P+A A P + + + ++ LAGG+AG P + VK LQ +H
Sbjct: 15 PPPAMPQAAGAGGPTTRRD--FYWLRSFLAGGIAGCCAKTTVAPLDRVKVLLQA--HNHH 70
Query: 62 PRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDS 121
++ G+ +R + G LGLY+G +++ P A++F FE + G
Sbjct: 71 YKHLGVFSALRAVPQKEGFLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTLITTKLGISGH 130
Query: 122 TRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSPNPKYRGFFHGVREI-VREQGLKGT 180
L+ G AG+ AV+ P++ ++V+ Q Y G H + I +E G G
Sbjct: 131 VHRLMAGSMAGMT-AVICTYPLDMVRVRLAF-QVKGEHSYTGIIHAFKTIYAKEGGFFGF 188
Query: 181 YQGLTATVLKQGSNQAIRFFVMTSLRN-----------WYRGDNPN-----KPMNPLITG 224
Y+GL T+L + FF +L++ DNPN +N L G
Sbjct: 189 YRGLMPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGG 248
Query: 225 VFGAIAGAASVFGNTPLDVIKTRMQ-GL---EAHKYRNTWDCGLQILKKEGL-KAFYKGT 279
V GAIA S P DV + RMQ G E K D + G+ K Y+G
Sbjct: 249 VAGAIAQTISY----PFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIRKGLYRGL 304
Query: 280 VPRLGRVCLDVAIVFVIYD 298
R A+ F Y+
Sbjct: 305 SLNYIRCIPSQAVAFTTYE 323
Score = 46.6 bits (109), Expect = 3e-05
Identities = 51/206 (24%), Positives = 79/206 (38%), Gaps = 35/206 (16%)
Query: 29 ILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQT-VRSHGVLGLYRGL 87
++AG +AG + T+P + V+ +L + Y GI + + G G YRGL
Sbjct: 134 LMAGSMAGMTAVICTYPLDMVRVRLAFQVKGEHS-YTGIIHAFKTIYAKEGGFFGFYRGL 192
Query: 88 SSLLYGSIPKAAVRFGMFEFLSN----HMRDAQGRLDSTR----------GLLCGLGAGV 133
+ G P A V F F L + H GR S LLCG AG
Sbjct: 193 MPTILGMAPYAGVSFFTFGTLKSVGLSHAPTLLGRPSSDNPNVLVLKTHVNLLCGGVAG- 251
Query: 134 AEAVVVVCPMETIKVKFIHDQTSPN----------PKYRGFFHGVREIVREQGLKGTYQG 183
A A + P + + + P KY HG+R KG Y+G
Sbjct: 252 AIAQTISYPFDVTRRRMQLGTVLPEFEKCLTMRDTMKYVYGHHGIR--------KGLYRG 303
Query: 184 LTATVLKQGSNQAIRFFVMTSLRNWY 209
L+ ++ +QA+ F ++ ++
Sbjct: 304 LSLNYIRCIPSQAVAFTTYELMKQFF 329
Score = 32.0 bits (71), Expect = 0.72
Identities = 22/79 (27%), Positives = 35/79 (44%), Gaps = 1/79 (1%)
Query: 227 GAIAGAASVFGNTPLDVIKTRMQGLEAH-KYRNTWDCGLQILKKEGLKAFYKGTVPRLGR 285
G IAG + PLD +K +Q H K+ + + +KEG YKG + R
Sbjct: 43 GGIAGCCAKTTVAPLDRVKVLLQAHNHHYKHLGVFSALRAVPQKEGFLGLYKGNGAMMIR 102
Query: 286 VCLDVAIVFVIYDEVVKLL 304
+ AI F+ ++ L+
Sbjct: 103 IFPYGAIQFMAFEHYKTLI 121
>gi|20149598 solute carrier family 25 (mitochondrial carrier;
dicarboxylate transporter), member 10 [Homo sapiens]
Length = 287
Score = 88.2 bits (217), Expect = 8e-18
Identities = 80/281 (28%), Positives = 128/281 (45%), Gaps = 24/281 (8%)
Query: 32 GGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLL 91
GGLA C T P + +K LQ + + R G +R VR+ G+L LY GLS+ L
Sbjct: 13 GGLASCGAACCTHPLDLLKVHLQTQQEV---KLRMTGMALR-VVRTDGILALYSGLSASL 68
Query: 92 YGSIPKAAVRFGMFEFLSNHM-RDAQGRLDSTRGLLCGLGAGVAEAVVVVCPMETIKVKF 150
+ + RF ++E + + + + +QG L +L G +G+A V P + + V+
Sbjct: 69 CRQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKVLLGSVSGLAGGFVGT-PADLVNVRM 127
Query: 151 IHDQTSPNPKYRGFFH---GVREIVREQGLKGTYQGLT-----ATVLKQGSNQAIRFFVM 202
+D P + R + H G+ + RE+GL+ + G T ++ G
Sbjct: 128 QNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQ 187
Query: 203 TSLRNWYRGDNPNKPMNPLITG-VFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWD 261
L Y DN + T V IAG + F PLDV+KTR+ + +Y+ +
Sbjct: 188 LVLSTGYLSDN-------IFTHFVASFIAGGCATFLCQPLDVLKTRLMNSKG-EYQGVFH 239
Query: 262 CGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVK 302
C ++ K G AFYKG VP R+ + FV +++ K
Sbjct: 240 CAVETAKL-GPLAFYKGLVPAGIRLIPHTVLTFVFLEQLRK 279
Score = 55.5 bits (132), Expect = 6e-08
Identities = 46/182 (25%), Positives = 82/182 (45%), Gaps = 15/182 (8%)
Query: 132 GVAEAVVVVC--PMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVL 189
G+A C P++ +KV H QT K R +R +VR G+ Y GL+A++
Sbjct: 14 GLASCGAACCTHPLDLLKV---HLQTQQEVKLRMTGMALR-VVRTDGILALYSGLSASLC 69
Query: 190 KQGSNQAIRFFVMTSLRNWY-RGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRM 248
+Q + RF + ++R+ +G P + + + G+++G A F TP D++ RM
Sbjct: 70 RQMTYSLTRFAIYETVRDRVAKGSQGPLPFHEKV--LLGSVSGLAGGFVGTPADLVNVRM 127
Query: 249 QGL------EAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVK 302
Q + Y + D ++ ++EGL+ + G R L YD+ +
Sbjct: 128 QNDVKLPQGQRRNYAHALDGLYRVAREEGLRRLFSGATMASSRGALVTVGQLSCYDQAKQ 187
Query: 303 LL 304
L+
Sbjct: 188 LV 189
Score = 35.4 bits (80), Expect = 0.065
Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 1/75 (1%)
Query: 226 FGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGR 285
FG +A + PLD++K +Q + K R T L++++ +G+ A Y G L R
Sbjct: 12 FGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMT-GMALRVVRTDGILALYSGLSASLCR 70
Query: 286 VCLDVAIVFVIYDEV 300
F IY+ V
Sbjct: 71 QMTYSLTRFAIYETV 85
>gi|7657585 mitochondrial ornithine transporter 1 [Homo sapiens]
Length = 301
Score = 87.8 bits (216), Expect = 1e-17
Identities = 76/290 (26%), Positives = 127/290 (43%), Gaps = 23/290 (7%)
Query: 30 LAGGLAGGIEICITF-PTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLS 88
L G AGG +T P + +K ++Q + P YRG+ DC +T G G Y+G S
Sbjct: 13 LTAGAAGGTACVLTGQPFDTMKVKMQ----TFPDLYRGLTDCCLKTYSQVGFRGFYKGTS 68
Query: 89 SLLYGSIPKAAVRFGMFEFLSNHMR-----DAQGRLDSTRGLLCGLGAGVAEAVVVVCPM 143
L +I + +V F + F +R D Q +L + G A A A +V+CP
Sbjct: 69 PALIANIAENSVLFMCYGFCQQVVRKVAGLDKQAKLSDLQNAAAGSFAS-AFAALVLCPT 127
Query: 144 ETIKVKFIHDQTSPNPKYRG--------FFHGVREIVREQGLKGTYQGLTATVLKQGSNQ 195
E +K + QT + G + ++ I+R+ G G Y GL++T+L++
Sbjct: 128 ELVKCRL---QTMYEMETSGKIAKSQNTVWSVIKSILRKDGPLGFYHGLSSTLLREVPGY 184
Query: 196 AIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLE-AH 254
F R+++ + P+ + G + G P+D IK+R+Q L +
Sbjct: 185 FFFFGGYELSRSFFASGRSKDELGPVPLMLSGGVGGICLWLAVYPVDCIKSRIQVLSMSG 244
Query: 255 KYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLL 304
K + ++K EG+ A Y G P + R +F+ Y+ KL+
Sbjct: 245 KQAGFIRTFINVVKNEGITALYSGLKPTMIRAFPANGALFLAYEYSRKLM 294
Score = 47.8 bits (112), Expect = 1e-05
Identities = 27/81 (33%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 227 GAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRV 286
GA G A V P D +K +MQ YR DC L+ + G + FYKGT P L
Sbjct: 16 GAAGGTACVLTGQPFDTMKVKMQTFP-DLYRGLTDCCLKTYSQVGFRGFYKGTSPALIAN 74
Query: 287 CLDVAIVFVIYDEVVKLLNKV 307
+ +++F+ Y +++ KV
Sbjct: 75 IAENSVLFMCYGFCQQVVRKV 95
>gi|156071462 solute carrier family 25, member A6 [Homo sapiens]
Length = 298
Score = 87.8 bits (216), Expect = 1e-17
Identities = 81/297 (27%), Positives = 131/297 (44%), Gaps = 27/297 (9%)
Query: 27 KAILAGGLAGGIEICITFPTEYVKTQLQLDERSHP----PRYRGIGDCVRQTVRSHGVLG 82
K LAGG+A I P E VK LQ+ S +Y+GI DC+ + + GVL
Sbjct: 10 KDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLS 69
Query: 83 LYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDS-------TRGLLCGLGAGVAE 135
+RG + + P A+ F F + + G +D G L GA A
Sbjct: 70 FWRGNLANVIRYFPTQALNFA---FKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGAT 126
Query: 136 AVVVVCPMETIKVKFIHD--QTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGS 193
++ V P++ + + D ++ ++RG + +I + G++G YQG + +V
Sbjct: 127 SLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIII 186
Query: 194 NQAIRFFVMTSLRNWYRG-DNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLE 252
+A F V + + N + ++ +I A+AG S P D ++ RM
Sbjct: 187 YRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSY----PFDTVRRRMMMQS 242
Query: 253 AHK-----YRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKLL 304
K Y T DC +I + EG KAF+KG + R + A V V+YDE+ K++
Sbjct: 243 GRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDELKKVI 298
>gi|156071459 solute carrier family 25, member 5 [Homo sapiens]
Length = 298
Score = 86.7 bits (213), Expect = 2e-17
Identities = 82/295 (27%), Positives = 127/295 (43%), Gaps = 27/295 (9%)
Query: 27 KAILAGGLAGGIEICITFPTEYVKTQLQLDERSHP----PRYRGIGDCVRQTVRSHGVLG 82
K LAGG+A I P E VK LQ+ S +Y+GI DCV + + GVL
Sbjct: 10 KDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLS 69
Query: 83 LYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDST-------RGLLCGLGAGVAE 135
+RG + + P A+ F F + + G +D G L GA A
Sbjct: 70 FWRGNLANVIRYFPTQALNFA---FKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGAT 126
Query: 136 AVVVVCPMETIKVKFIHD--QTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGS 193
++ V P++ + + D + ++RG + +I + G+KG YQG +V
Sbjct: 127 SLCFVYPLDFARTRLAADVGKAGAEREFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIII 186
Query: 194 NQAIRFFVMTSLRNWYRG-DNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLE 252
+A F + + + N + ++ +I A+AG S P D ++ RM
Sbjct: 187 YRAAYFGIYDTAKGMLPDPKNTHIVISWMIAQTVTAVAGLTSY----PFDTVRRRMMMQS 242
Query: 253 AHK-----YRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVK 302
K Y T DC +I + EG KAF+KG + R + A V V+YDE+ K
Sbjct: 243 GRKGTDIMYTGTLDCWRKIARDEGGKAFFKGAWSNVLR-GMGGAFVLVLYDEIKK 296
Score = 61.2 bits (147), Expect = 1e-09
Identities = 53/191 (27%), Positives = 85/191 (44%), Gaps = 16/191 (8%)
Query: 129 LGAGVAEAV--VVVCPMETIK----VKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQ 182
L GVA A+ V P+E +K V+ Q + + +Y+G V I +EQG+ ++
Sbjct: 13 LAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRIPKEQGVLSFWR 72
Query: 183 GLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITG---VFGAIAGAASVFGNT 239
G A V++ QA+ F + + G + L G AGA S+
Sbjct: 73 GNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWLYFAGNLASGGAAGATSLCFVY 132
Query: 240 PLDVIKTRM------QGLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIV 293
PLD +TR+ G E ++R DC ++I K +G+K Y+G + + + A
Sbjct: 133 PLDFARTRLAADVGKAGAE-REFRGLGDCLVKIYKSDGIKGLYQGFNVSVQGIIIYRAAY 191
Query: 294 FVIYDEVVKLL 304
F IYD +L
Sbjct: 192 FGIYDTAKGML 202
>gi|116235466 solute carrier family 25, member 45 isoform b [Homo
sapiens]
Length = 246
Score = 85.5 bits (210), Expect = 5e-17
Identities = 67/242 (27%), Positives = 108/242 (44%), Gaps = 19/242 (7%)
Query: 76 RSHGVLGLYRGLSSLLYGSIPKAAVRFGMFE------FLSNHMRDAQGRLDSTRGLLCGL 129
R +LG ++G+S + +V FG++ ++H L G
Sbjct: 6 RHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGC 65
Query: 130 GAGVAEAVVVVCPMETIKVKFIHDQT-------SPNPKYRGFFHGVREIVREQGLKGTYQ 182
G +A + P + IKV+ + +QT SP P+Y+G H I RE+G +G ++
Sbjct: 66 TGGFLQAYCLA-PFDLIKVR-LQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFR 123
Query: 183 GLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLD 242
G A L+ I F L Y + N ++ V G AG AS TPLD
Sbjct: 124 GAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVL--VAGGFAGIASWVAATPLD 181
Query: 243 VIKTRMQ--GLEAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEV 300
+IK+RMQ GL Y+ DC + +++EGL F++G R A+ F+ Y+ +
Sbjct: 182 MIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYL 241
Query: 301 VK 302
++
Sbjct: 242 LR 243
Score = 57.4 bits (137), Expect = 2e-08
Identities = 48/186 (25%), Positives = 75/186 (40%), Gaps = 8/186 (4%)
Query: 30 LAGGLAGGIEICITFPTEYVKTQLQLDER------SHPPRYRGIGDCVRQTVRSHGVLGL 83
LAG G ++ P + +K +LQ S PPRY+G C R G GL
Sbjct: 62 LAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGL 121
Query: 84 YRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCPM 143
+RG +L P + F +E L S L+ G AG+A + V P+
Sbjct: 122 FRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIA-SWVAATPL 180
Query: 144 ETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMT 203
+ IK + D Y+G + +R++GL ++G+T + A+ F
Sbjct: 181 DMIKSRMQMDGLR-RRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYE 239
Query: 204 SLRNWY 209
L W+
Sbjct: 240 YLLRWW 245
Score = 40.4 bits (93), Expect = 0.002
Identities = 23/80 (28%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 29 ILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPRYRGIGDCVRQTVRSHGVLGLYRGLS 88
++AGG AG P + +K+++Q+D Y+G+ DC+ ++R G+ +RG++
Sbjct: 163 LVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRV-YQGMLDCMVSSIRQEGLGVFFRGVT 221
Query: 89 SLLYGSIPKAAVRFGMFEFL 108
+ P AV F +E+L
Sbjct: 222 INSARAFPVNAVTFLSYEYL 241
>gi|58197562 solute carrier family 25, member 30 [Homo sapiens]
Length = 291
Score = 84.3 bits (207), Expect = 1e-16
Identities = 71/298 (23%), Positives = 123/298 (41%), Gaps = 36/298 (12%)
Query: 27 KAILAGGLAGGIEICITFPTEYVKTQLQL-----DERSHPPRYRGIGDCVRQTVRSHGVL 81
K + GGLA C TFP + KT+LQ+ D + RYRG+ + + R G+
Sbjct: 7 KPFVYGGLASITAECGTFPIDLTKTRLQIQGQTNDAKFKEIRYRGMLHALVRIGREEGLK 66
Query: 82 GLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSTRGLLCGLGAGVAEAVVVVC 141
LY G++ + ++ G ++ L + ++CG+ +GV + +
Sbjct: 67 ALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLPINVICGILSGVISSTIAN- 125
Query: 142 PMETIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFV 201
P + +K++ Q N G I +++G +G ++G++ T + + V
Sbjct: 126 PTDVLKIRM---QAQSNTIQGGMIGNFMNIYQQEGTRGLWKGVSLTAQRAAIVVGVELPV 182
Query: 202 MTSLRNWYRGDNPNKPMNPLITGVFGAIA----------GAASVFGNTPLDVIKTRMQGL 251
+ + +++G+ G G A + P+DV++TRM
Sbjct: 183 YDITKK-----------HLILSGLMGDTVYTHFLSSFTCGLAGALASNPVDVVRTRMMNQ 231
Query: 252 EAHK------YRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVAIVFVIYDEVVKL 303
+ Y T DC LQ K EG A YKG P R+ I FV Y+++ KL
Sbjct: 232 RVLRDGRCSGYTGTLDCLLQTWKNEGFFALYKGFWPNWLRLGPWNIIFFVTYEQLKKL 289
Score = 61.2 bits (147), Expect = 1e-09
Identities = 42/147 (28%), Positives = 66/147 (44%), Gaps = 6/147 (4%)
Query: 160 KYRGFFHGVREIVREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWY--RGDNPNKP 217
+YRG H + I RE+GLK Y G+ +L+Q S I+ SL+ + R ++ P
Sbjct: 48 RYRGMLHALVRIGREEGLKALYSGIAPAMLRQASYGTIKIGTYQSLKRLFIERPEDETLP 107
Query: 218 MNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHKYRNTWDCGLQILKKEGLKAFYK 277
+N + G ++G S P DV+K RMQ + I ++EG + +K
Sbjct: 108 INV----ICGILSGVISSTIANPTDVLKIRMQAQSNTIQGGMIGNFMNIYQQEGTRGLWK 163
Query: 278 GTVPRLGRVCLDVAIVFVIYDEVVKLL 304
G R + V + +YD K L
Sbjct: 164 GVSLTAQRAAIVVGVELPVYDITKKHL 190
>gi|13259546 uncoupling protein 3 isoform UCP3S [Homo sapiens]
Length = 275
Score = 83.6 bits (205), Expect = 2e-16
Identities = 68/263 (25%), Positives = 118/263 (44%), Gaps = 19/263 (7%)
Query: 30 LAGGLAGGIEICITFPTEYVKTQLQLD------ERSHPPRYRGIGDCVRQTVRSHGVLGL 83
L G A +TFP + K +LQ+ + + +YRG+ + VR+ G
Sbjct: 18 LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77
Query: 84 YRGLSSLLYGSIPKAAVRFGMFEFLSN-HMRDAQGRLDSTRGLLCGLGAGVAEAVVVVCP 142
Y GL + L + A++R G+++ + + T +L G G A AV P
Sbjct: 78 YNGLVAGLQRQMSFASIRIGLYDSVKQVYTPKGADNSSLTTRILAGCTTG-AMAVTCAQP 136
Query: 143 METIKVKF---IH-DQTSPNPKYRGFFHGVREIVREQGLKGTYQGLTATVLKQG---SNQ 195
+ +KV+F IH + + KY G R I RE+G++G ++G +++ +
Sbjct: 137 TDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNCAE 196
Query: 196 AIRFFVMTSLRNWYRGDNPNKPMNPLITGVFGAIAGAASVFGNTPLDVIKTRMQGLEAHK 255
+ + ++ Y N P + FGA G + +P+DV+KTR +
Sbjct: 197 VVTYDILKEKLLDYHLLTDNFPCH--FVSAFGA--GFCATVVASPVDVVKTRYMNSPPGQ 252
Query: 256 YRNTWDCGLQILKKEGLKAFYKG 278
Y + DC ++++ +EG AFYKG
Sbjct: 253 YFSPLDCMIKMVAQEGPTAFYKG 275
Score = 65.5 bits (158), Expect = 6e-11
Identities = 57/187 (30%), Positives = 84/187 (44%), Gaps = 20/187 (10%)
Query: 129 LGAGVAE--AVVVVCPMETIKVKFIHD------QTSPNPKYRGFFHGVREIVREQGLKGT 180
LGAG A A +V P++T KV+ QT+ +YRG + +VR +G
Sbjct: 18 LGAGTAACFADLVTFPLDTAKVRLQIQGENQAVQTARLVQYRGVLGTILTMVRTEGPCSP 77
Query: 181 YQGLTATVLKQGSNQAIRFFVMTSLRNWYRGDNPNKPMNPLITG--VFGAIAGAASVFGN 238
Y GL A + +Q S +IR + S++ Y P N +T + G GA +V
Sbjct: 78 YNGLVAGLQRQMSFASIRIGLYDSVKQVY---TPKGADNSSLTTRILAGCTTGAMAVTCA 134
Query: 239 TPLDVIKTRMQGL-------EAHKYRNTWDCGLQILKKEGLKAFYKGTVPRLGRVCLDVA 291
P DV+K R Q KY T D I ++EG++ +KGT+P + R +
Sbjct: 135 QPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLWKGTLPNIMRNAIVNC 194
Query: 292 IVFVIYD 298
V YD
Sbjct: 195 AEVVTYD 201
Score = 47.4 bits (111), Expect = 2e-05
Identities = 43/161 (26%), Positives = 72/161 (44%), Gaps = 11/161 (6%)
Query: 29 ILAGGLAGGIEICITFPTEYVKTQLQLDERSHPPR----YRGIGDCVRQTVRSHGVLGLY 84
ILAG G + + PT+ VK + Q P R Y G D R R GV GL+
Sbjct: 120 ILAGCTTGAMAVTCAQPTDVVKVRFQASIHLGPSRSDRKYSGTMDAYRTIAREEGVRGLW 179
Query: 85 RG-LSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDS-TRGLLCGLGAGVAEAVVVVCP 142
+G L +++ +I A ++ L + D D+ + GAG A VV P
Sbjct: 180 KGTLPNIMRNAIVNCA-EVVTYDILKEKLLDYHLLTDNFPCHFVSAFGAGFC-ATVVASP 237
Query: 143 METIKVKFIHDQTSPNPKYRGFFHGVREIVREQGLKGTYQG 183
++ +K ++++ SP +Y + ++V ++G Y+G
Sbjct: 238 VDVVKTRYMN---SPPGQYFSPLDCMIKMVAQEGPTAFYKG 275
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.427
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,826,178
Number of Sequences: 37866
Number of extensions: 510281
Number of successful extensions: 1968
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 1305
Number of HSP's gapped (non-prelim): 216
length of query: 311
length of database: 18,247,518
effective HSP length: 102
effective length of query: 209
effective length of database: 14,385,186
effective search space: 3006503874
effective search space used: 3006503874
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.