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Search of human proteins with 113722120
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|113722120 G protein-coupled receptor 98 precursor [Homo
sapiens]
(6306 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens] 1.241e+04 0.0
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 96 1e-18
gi|59710093 G-protein coupled receptor 112 [Homo sapiens] 94 4e-18
gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens] 94 6e-18
gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens] 94 6e-18
gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens] 94 6e-18
gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens] 94 6e-18
gi|6912464 latrophilin 2 precursor [Homo sapiens] 93 7e-18
gi|163792198 latrophilin 3 precursor [Homo sapiens] 93 1e-17
gi|57165355 latrophilin 1 isoform 1 precursor [Homo sapiens] 90 6e-17
gi|41281557 latrophilin 1 isoform 2 precursor [Homo sapiens] 90 6e-17
gi|238859647 G protein-coupled receptor 128 [Homo sapiens] 88 3e-16
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 87 5e-16
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 87 7e-16
gi|148806925 EGF, latrophilin and seven transmembrane domain con... 87 7e-16
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 84 3e-15
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 84 3e-15
gi|74048357 G protein-coupled receptor 126 alpha 1 precursor [Ho... 83 8e-15
gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Hom... 83 8e-15
gi|74048422 G protein-coupled receptor 126 alpha 2 precursor [Ho... 83 8e-15
gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Hom... 83 8e-15
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 83 1e-14
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 82 1e-14
gi|45433552 G protein-coupled receptor 133 [Homo sapiens] 82 2e-14
gi|133930786 egf-like module-containing mucin-like receptor 3 [H... 81 4e-14
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 80 5e-14
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 80 5e-14
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 80 5e-14
gi|24475871 G protein-coupled receptor 114 [Homo sapiens] 79 1e-13
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 78 2e-13
>gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]
Length = 6306
Score = 1.241e+04 bits (32198), Expect = 0.0
Identities = 6306/6306 (100%), Positives = 6306/6306 (100%)
Query: 1 MSVFLGPGMPSASLLVNLLSALLILFVFGETEIRFTGQTEFVVNETSTTVIRLIIERIGE 60
MSVFLGPGMPSASLLVNLLSALLILFVFGETEIRFTGQTEFVVNETSTTVIRLIIERIGE
Sbjct: 1 MSVFLGPGMPSASLLVNLLSALLILFVFGETEIRFTGQTEFVVNETSTTVIRLIIERIGE 60
Query: 61 PANVTAIVSLYGEDAGDFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDETFIFHLTLQK 120
PANVTAIVSLYGEDAGDFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDETFIFHLTLQK
Sbjct: 61 PANVTAIVSLYGEDAGDFFDTYAAAFIPAGETNRTVYIAVCDDDLPEPDETFIFHLTLQK 120
Query: 121 PSANVKLGWPRTVTVTILSNDNAFGIISFNMLPSIAVSEPKGRNESMPLTLIREKGTYGM 180
PSANVKLGWPRTVTVTILSNDNAFGIISFNMLPSIAVSEPKGRNESMPLTLIREKGTYGM
Sbjct: 121 PSANVKLGWPRTVTVTILSNDNAFGIISFNMLPSIAVSEPKGRNESMPLTLIREKGTYGM 180
Query: 181 VMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVE 240
VMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVE
Sbjct: 181 VMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVE 240
Query: 241 GGAEINTSRNSIEIIIKKNDSPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYE 300
GGAEINTSRNSIEIIIKKNDSPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYE
Sbjct: 241 GGAEINTSRNSIEIIIKKNDSPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYE 300
Query: 301 VSISYAVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHI 360
VSISYAVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHI
Sbjct: 301 VSISYAVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHI 360
Query: 361 MLLKDTLQGDAVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYEEITVV 420
MLLKDTLQGDAVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYEEITVV
Sbjct: 361 MLLKDTLQGDAVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYEEITVV 420
Query: 421 RNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEA 480
RNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEA
Sbjct: 421 RNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLPEEA 480
Query: 481 EAYLLQILPHTIRGGAEVSEPAELLFYIQDSDDVYGLITFFPMENQKIESSPGERYLSLS 540
EAYLLQILPHTIRGGAEVSEPAELLFYIQDSDDVYGLITFFPMENQKIESSPGERYLSLS
Sbjct: 481 EAYLLQILPHTIRGGAEVSEPAELLFYIQDSDDVYGLITFFPMENQKIESSPGERYLSLS 540
Query: 541 FTRLGGTKGDVRLLYSVLYIPAGAVDPLQAKEGILNISRRNDLIFPEQKTQVTTKLPIRN 600
FTRLGGTKGDVRLLYSVLYIPAGAVDPLQAKEGILNISRRNDLIFPEQKTQVTTKLPIRN
Sbjct: 541 FTRLGGTKGDVRLLYSVLYIPAGAVDPLQAKEGILNISRRNDLIFPEQKTQVTTKLPIRN 600
Query: 601 DAFLQNGAHFLVQLETVELLNIIPLIPPISPRFGEICNISLLVTPAIANGEIGFLSNLPI 660
DAFLQNGAHFLVQLETVELLNIIPLIPPISPRFGEICNISLLVTPAIANGEIGFLSNLPI
Sbjct: 601 DAFLQNGAHFLVQLETVELLNIIPLIPPISPRFGEICNISLLVTPAIANGEIGFLSNLPI 660
Query: 661 ILHEPEDFAAEVVYIPLHRDGTDGQATVYWSLKPSGFNSKAVTPDDIGPFNGSVLFLSGQ 720
ILHEPEDFAAEVVYIPLHRDGTDGQATVYWSLKPSGFNSKAVTPDDIGPFNGSVLFLSGQ
Sbjct: 661 ILHEPEDFAAEVVYIPLHRDGTDGQATVYWSLKPSGFNSKAVTPDDIGPFNGSVLFLSGQ 720
Query: 721 SDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSGYTSRDLIILENDDPGGVFEFSP 780
SDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSGYTSRDLIILENDDPGGVFEFSP
Sbjct: 721 SDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSGYTSRDLIILENDDPGGVFEFSP 780
Query: 781 ASRGPYVIKEGESVELHIIRSRGSLVKQFLHYRVEPRDSNEFYGNTGVLEFKPGEREIVI 840
ASRGPYVIKEGESVELHIIRSRGSLVKQFLHYRVEPRDSNEFYGNTGVLEFKPGEREIVI
Sbjct: 781 ASRGPYVIKEGESVELHIIRSRGSLVKQFLHYRVEPRDSNEFYGNTGVLEFKPGEREIVI 840
Query: 841 TLLARLDGIPELDEHYWVVLSSHGERESKLGSATIVNITILKNDDPHGIIEFVSDGLIVM 900
TLLARLDGIPELDEHYWVVLSSHGERESKLGSATIVNITILKNDDPHGIIEFVSDGLIVM
Sbjct: 841 TLLARLDGIPELDEHYWVVLSSHGERESKLGSATIVNITILKNDDPHGIIEFVSDGLIVM 900
Query: 901 INESKGDAIYSAVYDVVRNRGNFGDVSVSWVVSPDFTQDVFPVQGTVVFGDQEFSKNITI 960
INESKGDAIYSAVYDVVRNRGNFGDVSVSWVVSPDFTQDVFPVQGTVVFGDQEFSKNITI
Sbjct: 901 INESKGDAIYSAVYDVVRNRGNFGDVSVSWVVSPDFTQDVFPVQGTVVFGDQEFSKNITI 960
Query: 961 YSLPDEIPEEMEEFTVILLNGTGGAKVGNRTTATLRIRRNDDPIYFAEPRVVRVQEGETA 1020
YSLPDEIPEEMEEFTVILLNGTGGAKVGNRTTATLRIRRNDDPIYFAEPRVVRVQEGETA
Sbjct: 961 YSLPDEIPEEMEEFTVILLNGTGGAKVGNRTTATLRIRRNDDPIYFAEPRVVRVQEGETA 1020
Query: 1021 NFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDG 1080
NFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDG
Sbjct: 1021 NFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDG 1080
Query: 1081 IPETDEPFYIILLNSTGDTVVYQYGVATVIIEANDDPNGIFSLEPIDKAVEEGKTNAFWI 1140
IPETDEPFYIILLNSTGDTVVYQYGVATVIIEANDDPNGIFSLEPIDKAVEEGKTNAFWI
Sbjct: 1081 IPETDEPFYIILLNSTGDTVVYQYGVATVIIEANDDPNGIFSLEPIDKAVEEGKTNAFWI 1140
Query: 1141 LRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFN 1200
LRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFN
Sbjct: 1141 LRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGEEAKPIILHAFPDKIPEFN 1200
Query: 1201 EFYFLKLVNISGGSPGPGGQLAETNLQVTVMVPFNDDPFGVFILDPECLEREVAEDVLSE 1260
EFYFLKLVNISGGSPGPGGQLAETNLQVTVMVPFNDDPFGVFILDPECLEREVAEDVLSE
Sbjct: 1201 EFYFLKLVNISGGSPGPGGQLAETNLQVTVMVPFNDDPFGVFILDPECLEREVAEDVLSE 1260
Query: 1261 DDMSYITNFTILRQQGVFGDVQLGWEILSSEFPAGLPPMIDFLLVGIFPTTVHLQQHMRR 1320
DDMSYITNFTILRQQGVFGDVQLGWEILSSEFPAGLPPMIDFLLVGIFPTTVHLQQHMRR
Sbjct: 1261 DDMSYITNFTILRQQGVFGDVQLGWEILSSEFPAGLPPMIDFLLVGIFPTTVHLQQHMRR 1320
Query: 1321 HHSGTDALYFTGLEGAFGTVNPKYHPSRNNTIANFTFSAWVMPNANTNGFIIAKDDGNGS 1380
HHSGTDALYFTGLEGAFGTVNPKYHPSRNNTIANFTFSAWVMPNANTNGFIIAKDDGNGS
Sbjct: 1321 HHSGTDALYFTGLEGAFGTVNPKYHPSRNNTIANFTFSAWVMPNANTNGFIIAKDDGNGS 1380
Query: 1381 IYYGVKIQTNESHVTLSLHYKTLGSNATYIAKTTVMKYLEESVWLHLLIILEDGIIEFYL 1440
IYYGVKIQTNESHVTLSLHYKTLGSNATYIAKTTVMKYLEESVWLHLLIILEDGIIEFYL
Sbjct: 1381 IYYGVKIQTNESHVTLSLHYKTLGSNATYIAKTTVMKYLEESVWLHLLIILEDGIIEFYL 1440
Query: 1441 DGNAMPRGIKSLKGEAITDGPGILRIGAGINGNDRFTGLMQDVRSYERKLTLEEIYELHA 1500
DGNAMPRGIKSLKGEAITDGPGILRIGAGINGNDRFTGLMQDVRSYERKLTLEEIYELHA
Sbjct: 1441 DGNAMPRGIKSLKGEAITDGPGILRIGAGINGNDRFTGLMQDVRSYERKLTLEEIYELHA 1500
Query: 1501 MPAKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEENTT 1560
MPAKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEENTT
Sbjct: 1501 MPAKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEENTT 1560
Query: 1561 ARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGI 1620
ARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGI
Sbjct: 1561 ARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGI 1620
Query: 1621 NYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTLVSAIPGDGKLGSTPT 1680
NYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTLVSAIPGDGKLGSTPT
Sbjct: 1621 NYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTLVSAIPGDGKLGSTPT 1680
Query: 1681 SGASIDPEKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIR 1740
SGASIDPEKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIR
Sbjct: 1681 SGASIDPEKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIR 1740
Query: 1741 LLVIRAQGLLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPEL 1800
LLVIRAQGLLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPEL
Sbjct: 1741 LLVIRAQGLLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPEL 1800
Query: 1801 EKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQILVTIAASDHA 1860
EKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQILVTIAASDHA
Sbjct: 1801 EKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQILVTIAASDHA 1860
Query: 1861 HGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHWNIDSDPDGDLAFTSGNI 1920
HGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHWNIDSDPDGDLAFTSGNI
Sbjct: 1861 HGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHWNIDSDPDGDLAFTSGNI 1920
Query: 1921 TFEIGQTSANITVEILPDEDPELDKAFSVSVLSVSSGSLGAHINATLTVLASDDPYGIFI 1980
TFEIGQTSANITVEILPDEDPELDKAFSVSVLSVSSGSLGAHINATLTVLASDDPYGIFI
Sbjct: 1921 TFEIGQTSANITVEILPDEDPELDKAFSVSVLSVSSGSLGAHINATLTVLASDDPYGIFI 1980
Query: 1981 FSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDY 2040
FSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDY
Sbjct: 1981 FSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDY 2040
Query: 2041 IPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSIPNSPRLGP 2100
IPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSIPNSPRLGP
Sbjct: 2041 IPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSIPNSPRLGP 2100
Query: 2101 KVETIAQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPIT 2160
KVETIAQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPIT
Sbjct: 2101 KVETIAQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPIT 2160
Query: 2161 AIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQLMNETTGGARLGALTE 2220
AIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQLMNETTGGARLGALTE
Sbjct: 2161 AIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQLMNETTGGARLGALTE 2220
Query: 2221 AVIIIEASDDPYGLFGFQITKLIVEEPEFNSVKVNLPIIRNSGTLGNVTVQWVATINGQL 2280
AVIIIEASDDPYGLFGFQITKLIVEEPEFNSVKVNLPIIRNSGTLGNVTVQWVATINGQL
Sbjct: 2221 AVIIIEASDDPYGLFGFQITKLIVEEPEFNSVKVNLPIIRNSGTLGNVTVQWVATINGQL 2280
Query: 2281 ATGDLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVIQVQLTDASGGGTIGLDRIANI 2340
ATGDLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVIQVQLTDASGGGTIGLDRIANI
Sbjct: 2281 ATGDLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVIQVQLTDASGGGTIGLDRIANI 2340
Query: 2341 IIPANDDPYGTVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRLLLFYSTSDIDVVALA 2400
IIPANDDPYGTVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRLLLFYSTSDIDVVALA
Sbjct: 2341 IIPANDDPYGTVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRLLLFYSTSDIDVVALA 2400
Query: 2401 MEEGQDLLSYYESPIQGVPDPLWRTWMNVSAVGEPLYTCATLCLKEQACSAFSFFSASEG 2460
MEEGQDLLSYYESPIQGVPDPLWRTWMNVSAVGEPLYTCATLCLKEQACSAFSFFSASEG
Sbjct: 2401 MEEGQDLLSYYESPIQGVPDPLWRTWMNVSAVGEPLYTCATLCLKEQACSAFSFFSASEG 2460
Query: 2461 PQCFWMTSWISPAVNNSDFWTYRKNMTRVASLFSGQAVAGSDYEPVTRQWAIMQEGDEFA 2520
PQCFWMTSWISPAVNNSDFWTYRKNMTRVASLFSGQAVAGSDYEPVTRQWAIMQEGDEFA
Sbjct: 2461 PQCFWMTSWISPAVNNSDFWTYRKNMTRVASLFSGQAVAGSDYEPVTRQWAIMQEGDEFA 2520
Query: 2521 NLTVSILPDDFPEMDESFLISLLEVHLMNISASLKNQPTIGQPNISTVVIALNGDAFGVF 2580
NLTVSILPDDFPEMDESFLISLLEVHLMNISASLKNQPTIGQPNISTVVIALNGDAFGVF
Sbjct: 2521 NLTVSILPDDFPEMDESFLISLLEVHLMNISASLKNQPTIGQPNISTVVIALNGDAFGVF 2580
Query: 2581 VIYNISPNTSEDGLFVEVQEQPQTLVELMIHRTGGSLGQVAVEWRVVGGTATEGLDFIGA 2640
VIYNISPNTSEDGLFVEVQEQPQTLVELMIHRTGGSLGQVAVEWRVVGGTATEGLDFIGA
Sbjct: 2581 VIYNISPNTSEDGLFVEVQEQPQTLVELMIHRTGGSLGQVAVEWRVVGGTATEGLDFIGA 2640
Query: 2641 GEILTFAEGETKKTVILTILDDSEPEDDESIIVSLVYTEGGSRILPSSDTVRVNILANDN 2700
GEILTFAEGETKKTVILTILDDSEPEDDESIIVSLVYTEGGSRILPSSDTVRVNILANDN
Sbjct: 2641 GEILTFAEGETKKTVILTILDDSEPEDDESIIVSLVYTEGGSRILPSSDTVRVNILANDN 2700
Query: 2701 VAGIVSFQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLELNFANFSGQLFF 2760
VAGIVSFQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLELNFANFSGQLFF
Sbjct: 2701 VAGIVSFQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLELNFANFSGQLFF 2760
Query: 2761 PEGSLNTTLFVHLLDDNIPEEKEVYQVILYDVRTQGVPPAGIALLDAQGYAAVLTVEASD 2820
PEGSLNTTLFVHLLDDNIPEEKEVYQVILYDVRTQGVPPAGIALLDAQGYAAVLTVEASD
Sbjct: 2761 PEGSLNTTLFVHLLDDNIPEEKEVYQVILYDVRTQGVPPAGIALLDAQGYAAVLTVEASD 2820
Query: 2821 EPHGVLNFALSSRFVLLQEANITIQLFINREFGSLGAINVTYTTVPGMLSLKNQTVGNLA 2880
EPHGVLNFALSSRFVLLQEANITIQLFINREFGSLGAINVTYTTVPGMLSLKNQTVGNLA
Sbjct: 2821 EPHGVLNFALSSRFVLLQEANITIQLFINREFGSLGAINVTYTTVPGMLSLKNQTVGNLA 2880
Query: 2881 EPEVDFVPIIGFLILEEGETAAAINITILEDDVPELEEYFLVNLTYVGLTMAASTSFPPR 2940
EPEVDFVPIIGFLILEEGETAAAINITILEDDVPELEEYFLVNLTYVGLTMAASTSFPPR
Sbjct: 2881 EPEVDFVPIIGFLILEEGETAAAINITILEDDVPELEEYFLVNLTYVGLTMAASTSFPPR 2940
Query: 2941 LDSEGLTAQVIIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVYAQN 3000
LDSEGLTAQVIIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVYAQN
Sbjct: 2941 LDSEGLTAQVIIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVYAQN 3000
Query: 3001 LEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNPSPGLELGKNT 3060
LEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNPSPGLELGKNT
Sbjct: 3001 LEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNPSPGLELGKNT 3060
Query: 3061 IALIIVLANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFI 3120
IALIIVLANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFI
Sbjct: 3061 IALIIVLANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFI 3120
Query: 3121 VTEVNSSNESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNPTGGARL 3180
VTEVNSSNESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNPTGGARL
Sbjct: 3121 VTEVNSSNESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNPTGGARL 3180
Query: 3181 GVHVQTLITVLQNQAPLGLFSISAVENRATSIDIEEANRTVYLNVSRTNGIDLAVSVQWE 3240
GVHVQTLITVLQNQAPLGLFSISAVENRATSIDIEEANRTVYLNVSRTNGIDLAVSVQWE
Sbjct: 3181 GVHVQTLITVLQNQAPLGLFSISAVENRATSIDIEEANRTVYLNVSRTNGIDLAVSVQWE 3240
Query: 3241 TVSETAFGMRGMDVVFSVFQSFLDESASGWCFFTLENLIYGIMLRKSSVTVYRWQGIFIP 3300
TVSETAFGMRGMDVVFSVFQSFLDESASGWCFFTLENLIYGIMLRKSSVTVYRWQGIFIP
Sbjct: 3241 TVSETAFGMRGMDVVFSVFQSFLDESASGWCFFTLENLIYGIMLRKSSVTVYRWQGIFIP 3300
Query: 3301 VEDLNIENPKTCEAFNIGFSPYFVITHEERNEEKPSLNSVFTFTSGFKLFLVQTIIILES 3360
VEDLNIENPKTCEAFNIGFSPYFVITHEERNEEKPSLNSVFTFTSGFKLFLVQTIIILES
Sbjct: 3301 VEDLNIENPKTCEAFNIGFSPYFVITHEERNEEKPSLNSVFTFTSGFKLFLVQTIIILES 3360
Query: 3361 SQVRYFTSDSQDYLIIASQRDDSELTQVFRWNGGSFVLHQKLPVRGVLTVALFNKGGSVF 3420
SQVRYFTSDSQDYLIIASQRDDSELTQVFRWNGGSFVLHQKLPVRGVLTVALFNKGGSVF
Sbjct: 3361 SQVRYFTSDSQDYLIIASQRDDSELTQVFRWNGGSFVLHQKLPVRGVLTVALFNKGGSVF 3420
Query: 3421 LAISQANARLNSLLFRWSGSGFINFQEVPVSGTTEVEALSSANDIYLIFAENVFLGDQNS 3480
LAISQANARLNSLLFRWSGSGFINFQEVPVSGTTEVEALSSANDIYLIFAENVFLGDQNS
Sbjct: 3421 LAISQANARLNSLLFRWSGSGFINFQEVPVSGTTEVEALSSANDIYLIFAENVFLGDQNS 3480
Query: 3481 IDIFIWEMGQSSFRYFQSVDFAAVNRIHSFTPASGIAHILLIGQDMSALYCWNSERNQFS 3540
IDIFIWEMGQSSFRYFQSVDFAAVNRIHSFTPASGIAHILLIGQDMSALYCWNSERNQFS
Sbjct: 3481 IDIFIWEMGQSSFRYFQSVDFAAVNRIHSFTPASGIAHILLIGQDMSALYCWNSERNQFS 3540
Query: 3541 FVLEVPSAYDVASVTVKSLNSSKNLIALVGAHSHIYELAYISSHSDFIPSSGELIFEPGE 3600
FVLEVPSAYDVASVTVKSLNSSKNLIALVGAHSHIYELAYISSHSDFIPSSGELIFEPGE
Sbjct: 3541 FVLEVPSAYDVASVTVKSLNSSKNLIALVGAHSHIYELAYISSHSDFIPSSGELIFEPGE 3600
Query: 3601 REATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDSVTITILSNDDAYGIVAFAQNS 3660
REATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDSVTITILSNDDAYGIVAFAQNS
Sbjct: 3601 REATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDSVTITILSNDDAYGIVAFAQNS 3660
Query: 3661 LYKQVEEMEQDSLVTLNVERLKGTYGRITIAWEADGSISDIFPTSGVILFTEGQVLSTIT 3720
LYKQVEEMEQDSLVTLNVERLKGTYGRITIAWEADGSISDIFPTSGVILFTEGQVLSTIT
Sbjct: 3661 LYKQVEEMEQDSLVTLNVERLKGTYGRITIAWEADGSISDIFPTSGVILFTEGQVLSTIT 3720
Query: 3721 LTILADNIPELSEVVIVTLTRITTEGVEDSYKGATIDQDRSKSVITTLPNDSPFGLVGWR 3780
LTILADNIPELSEVVIVTLTRITTEGVEDSYKGATIDQDRSKSVITTLPNDSPFGLVGWR
Sbjct: 3721 LTILADNIPELSEVVIVTLTRITTEGVEDSYKGATIDQDRSKSVITTLPNDSPFGLVGWR 3780
Query: 3781 AASVFIRVAEPKENTTTLQLQIARDKGLLGDIAIHLRAQPNFLLHVDNQATENEDYVLQE 3840
AASVFIRVAEPKENTTTLQLQIARDKGLLGDIAIHLRAQPNFLLHVDNQATENEDYVLQE
Sbjct: 3781 AASVFIRVAEPKENTTTLQLQIARDKGLLGDIAIHLRAQPNFLLHVDNQATENEDYVLQE 3840
Query: 3841 TIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFSTGQPSVRRPGMEIAE 3900
TIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFSTGQPSVRRPGMEIAE
Sbjct: 3841 TIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFSTGQPSVRRPGMEIAE 3900
Query: 3901 IMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGAVNVYWKASPD 3960
IMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGAVNVYWKASPD
Sbjct: 3901 IMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGAVNVYWKASPD 3960
Query: 3961 SAGLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGGGRLGDDVVV 4020
SAGLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGGGRLGDDVVV
Sbjct: 3961 SAGLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGGGRLGDDVVV 4020
Query: 4021 TVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEWTIDEKA 4080
TVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEWTIDEKA
Sbjct: 4021 TVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEWTIDEKA 4080
Query: 4081 KHNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKGSASII 4140
KHNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKGSASII
Sbjct: 4081 KHNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKGSASII 4140
Query: 4141 IRGDKRASGEVGIAPSSRHILIGEPSAKYNGTAIISLVRGPGILGEVTVFWRIFPPSVGE 4200
IRGDKRASGEVGIAPSSRHILIGEPSAKYNGTAIISLVRGPGILGEVTVFWRIFPPSVGE
Sbjct: 4141 IRGDKRASGEVGIAPSSRHILIGEPSAKYNGTAIISLVRGPGILGEVTVFWRIFPPSVGE 4200
Query: 4201 FAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVSEGGVLSESSSTANITVV 4260
FAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVSEGGVLSESSSTANITVV
Sbjct: 4201 FAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVSEGGVLSESSSTANITVV 4260
Query: 4261 ASDSPYGRFAFSHEQLRVSEAQRVNITIIRSSGDFGHVRLWYKTMSGTAEAGLDFVPAAG 4320
ASDSPYGRFAFSHEQLRVSEAQRVNITIIRSSGDFGHVRLWYKTMSGTAEAGLDFVPAAG
Sbjct: 4261 ASDSPYGRFAFSHEQLRVSEAQRVNITIIRSSGDFGHVRLWYKTMSGTAEAGLDFVPAAG 4320
Query: 4321 ELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEI 4380
ELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEI
Sbjct: 4321 ELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEI 4380
Query: 4381 GNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQS 4440
GNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQS
Sbjct: 4381 GNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQS 4440
Query: 4441 SSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILLTGATGGAVLGRH 4500
SSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILLTGATGGAVLGRH
Sbjct: 4441 SSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILLTGATGGAVLGRH 4500
Query: 4501 LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPN 4560
LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPN
Sbjct: 4501 LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPN 4560
Query: 4561 SQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAK 4620
SQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAK
Sbjct: 4561 SQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAK 4620
Query: 4621 LDSRAKDVTLTIQEFGDPNGVVQFAPETLSKKTYSEPLALEGPLLITFFVRRVKGTFGEI 4680
LDSRAKDVTLTIQEFGDPNGVVQFAPETLSKKTYSEPLALEGPLLITFFVRRVKGTFGEI
Sbjct: 4621 LDSRAKDVTLTIQEFGDPNGVVQFAPETLSKKTYSEPLALEGPLLITFFVRRVKGTFGEI 4680
Query: 4681 MVYWELSSEFDITEDFLSTSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGG 4740
MVYWELSSEFDITEDFLSTSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGG
Sbjct: 4681 MVYWELSSEFDITEDFLSTSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGG 4740
Query: 4741 AELDLEKSITWFSVYANDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG 4800
AELDLEKSITWFSVYANDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG
Sbjct: 4741 AELDLEKSITWFSVYANDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG 4800
Query: 4801 LRISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQLVTVMLVGG 4860
LRISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQLVTVMLVGG
Sbjct: 4801 LRISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQLVTVMLVGG 4860
Query: 4861 RFYGMPTILQEAKSAVLPVSEKAANSQVGFESTAFQLMNITAGTSHVMISRRGTYGALSV 4920
RFYGMPTILQEAKSAVLPVSEKAANSQVGFESTAFQLMNITAGTSHVMISRRGTYGALSV
Sbjct: 4861 RFYGMPTILQEAKSAVLPVSEKAANSQVGFESTAFQLMNITAGTSHVMISRRGTYGALSV 4920
Query: 4921 AWTTGYAPGLEIPEFIVVGNMTPTLGSLSFSHGEQRKGVFLWTFPSPGWPEAFVLHLSGV 4980
AWTTGYAPGLEIPEFIVVGNMTPTLGSLSFSHGEQRKGVFLWTFPSPGWPEAFVLHLSGV
Sbjct: 4921 AWTTGYAPGLEIPEFIVVGNMTPTLGSLSFSHGEQRKGVFLWTFPSPGWPEAFVLHLSGV 4980
Query: 4981 QSSAPGGAQLRSGFIVAEIEPMGVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKV 5040
QSSAPGGAQLRSGFIVAEIEPMGVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKV
Sbjct: 4981 QSSAPGGAQLRSGFIVAEIEPMGVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKV 5040
Query: 5041 SYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIR 5100
SYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIR
Sbjct: 5041 SYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIR 5100
Query: 5101 GLQKFDVNWSPRLNLDFSVAVITILDNDDLAGMDISFPETTVAVAVDTTLIPVETESTTY 5160
GLQKFDVNWSPRLNLDFSVAVITILDNDDLAGMDISFPETTVAVAVDTTLIPVETESTTY
Sbjct: 5101 GLQKFDVNWSPRLNLDFSVAVITILDNDDLAGMDISFPETTVAVAVDTTLIPVETESTTY 5160
Query: 5161 LSTSKTTTILQPTNVVAIVTEATGVSAIPEKLVTLHGTPAVSEKPDVATVTANVSIHGTF 5220
LSTSKTTTILQPTNVVAIVTEATGVSAIPEKLVTLHGTPAVSEKPDVATVTANVSIHGTF
Sbjct: 5161 LSTSKTTTILQPTNVVAIVTEATGVSAIPEKLVTLHGTPAVSEKPDVATVTANVSIHGTF 5220
Query: 5221 SLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSITVKTFGERCAQMEPNALPFRGIY 5280
SLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSITVKTFGERCAQMEPNALPFRGIY
Sbjct: 5221 SLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSITVKTFGERCAQMEPNALPFRGIY 5280
Query: 5281 GISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQ 5340
GISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQ
Sbjct: 5281 GISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQ 5340
Query: 5341 IVEEKDDTGFAAFAMVIITGSDLHNGIIGFSEESQSGLELREGAVMRRLHLIVTRQPNRA 5400
IVEEKDDTGFAAFAMVIITGSDLHNGIIGFSEESQSGLELREGAVMRRLHLIVTRQPNRA
Sbjct: 5341 IVEEKDDTGFAAFAMVIITGSDLHNGIIGFSEESQSGLELREGAVMRRLHLIVTRQPNRA 5400
Query: 5401 FEDVKVFWRVTLNKTVVVLQKDGVNLVEELQSVSGTTTCTMGQTKCFISIELKPEKVPQV 5460
FEDVKVFWRVTLNKTVVVLQKDGVNLVEELQSVSGTTTCTMGQTKCFISIELKPEKVPQV
Sbjct: 5401 FEDVKVFWRVTLNKTVVVLQKDGVNLVEELQSVSGTTTCTMGQTKCFISIELKPEKVPQV 5460
Query: 5461 EVYFFVELYEATAGAAINNSARFAQIKILESDESQSLVYFSVGSRLAVAHKKATLISLQV 5520
EVYFFVELYEATAGAAINNSARFAQIKILESDESQSLVYFSVGSRLAVAHKKATLISLQV
Sbjct: 5461 EVYFFVELYEATAGAAINNSARFAQIKILESDESQSLVYFSVGSRLAVAHKKATLISLQV 5520
Query: 5521 ARDSGTGLMMSVNFSTQELRSAETIGRTIISPAISGKDFVITEGTLVFEPGQRSTVLDVI 5580
ARDSGTGLMMSVNFSTQELRSAETIGRTIISPAISGKDFVITEGTLVFEPGQRSTVLDVI
Sbjct: 5521 ARDSGTGLMMSVNFSTQELRSAETIGRTIISPAISGKDFVITEGTLVFEPGQRSTVLDVI 5580
Query: 5581 LTPETGSLNSFPKRFQIVLFDPKGGARIDKVYGTANITLVSDADSQAIWGLADQLHQPVN 5640
LTPETGSLNSFPKRFQIVLFDPKGGARIDKVYGTANITLVSDADSQAIWGLADQLHQPVN
Sbjct: 5581 LTPETGSLNSFPKRFQIVLFDPKGGARIDKVYGTANITLVSDADSQAIWGLADQLHQPVN 5640
Query: 5641 DDILNRVLHTISMKVATENTDEQLSAMMHLIEKITTEGKIQAFSVASRTLFYEILCSLIN 5700
DDILNRVLHTISMKVATENTDEQLSAMMHLIEKITTEGKIQAFSVASRTLFYEILCSLIN
Sbjct: 5641 DDILNRVLHTISMKVATENTDEQLSAMMHLIEKITTEGKIQAFSVASRTLFYEILCSLIN 5700
Query: 5701 PKRKDTRGFSHFAEVTENFAFSLLTNVTCGSPGEKSKTILDSCPYLSILALHWYPQQING 5760
PKRKDTRGFSHFAEVTENFAFSLLTNVTCGSPGEKSKTILDSCPYLSILALHWYPQQING
Sbjct: 5701 PKRKDTRGFSHFAEVTENFAFSLLTNVTCGSPGEKSKTILDSCPYLSILALHWYPQQING 5760
Query: 5761 HKFEGKEGDYIRIPERLLDVQDAEIMAGKSTCKLVQFTEYSSQQWFISGNNLPTLKNKVL 5820
HKFEGKEGDYIRIPERLLDVQDAEIMAGKSTCKLVQFTEYSSQQWFISGNNLPTLKNKVL
Sbjct: 5761 HKFEGKEGDYIRIPERLLDVQDAEIMAGKSTCKLVQFTEYSSQQWFISGNNLPTLKNKVL 5820
Query: 5821 SLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTSLCLLWNQAAASWLSDSQFCKVVEETA 5880
SLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTSLCLLWNQAAASWLSDSQFCKVVEETA
Sbjct: 5821 SLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTSLCLLWNQAAASWLSDSQFCKVVEETA 5880
Query: 5881 DYVECACSHMSVYAVYARTDNLSSYNEAFFTSGFICISGLCLAVLSHIFCARYSMFAAKL 5940
DYVECACSHMSVYAVYARTDNLSSYNEAFFTSGFICISGLCLAVLSHIFCARYSMFAAKL
Sbjct: 5881 DYVECACSHMSVYAVYARTDNLSSYNEAFFTSGFICISGLCLAVLSHIFCARYSMFAAKL 5940
Query: 5941 LTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLV 6000
LTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLV
Sbjct: 5941 LTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLV 6000
Query: 6001 MNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLCFIPNVYAA 6060
MNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLCFIPNVYAA
Sbjct: 6001 MNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLCFIPNVYAA 6060
Query: 6061 LFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWL 6120
LFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWL
Sbjct: 6061 LFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWL 6120
Query: 6121 WGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQMCCPMKASYTVEMNGHPGPSTA 6180
WGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQMCCPMKASYTVEMNGHPGPSTA
Sbjct: 6121 WGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQMCCPMKASYTVEMNGHPGPSTA 6180
Query: 6181 FFTPGSGMPPAGGEISKSTQNLIGAMEEVPPDWERASFQQGSQASPDLKPSPQNGATFPS 6240
FFTPGSGMPPAGGEISKSTQNLIGAMEEVPPDWERASFQQGSQASPDLKPSPQNGATFPS
Sbjct: 6181 FFTPGSGMPPAGGEISKSTQNLIGAMEEVPPDWERASFQQGSQASPDLKPSPQNGATFPS 6240
Query: 6241 SGGYGQGSLIADEESQEFDDLIFALKTGAGLSVSDNESGQGSQEGGTLTDSQIVELRRIP 6300
SGGYGQGSLIADEESQEFDDLIFALKTGAGLSVSDNESGQGSQEGGTLTDSQIVELRRIP
Sbjct: 6241 SGGYGQGSLIADEESQEFDDLIFALKTGAGLSVSDNESGQGSQEGGTLTDSQIVELRRIP 6300
Query: 6301 IADTHL 6306
IADTHL
Sbjct: 6301 IADTHL 6306
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 95.5 bits (236), Expect = 1e-18
Identities = 109/488 (22%), Positives = 200/488 (40%), Gaps = 52/488 (10%)
Query: 5813 PTLKNKVLSLSVKGQSSQL---LTNDNEVLYRIYAAEPRIIPQTSLCLLWNQA-----AA 5864
P + V+S+SV L L V +R+ E R P +C+ WN +
Sbjct: 2276 PIINTPVVSISVHDDEELLPRALDKPVTVQFRLLETEERTKP---ICVFWNHSILVSGTG 2332
Query: 5865 SWLSDSQFCKVVEETADYVECACSHMSVYAVYARTDNLSSYNEAFFTSGFICISGLCLAV 5924
W ++ C+VV +V C C+HM+ +AV + + G+ LA
Sbjct: 2333 GW--SARGCEVVFRNESHVSCQCNHMTSFAVLMDVSRRENGEILPLKTLTYVALGVTLAA 2390
Query: 5925 LSHIFCARYSMFAAKLLTH----MMAASLG-TQILFLASAYASPQLAEESCSAMAAVTHY 5979
L F + + H + A+LG Q++FL + +C+ +A + H+
Sbjct: 2391 LLLTFFFLTLLRILRSNQHGIRRNLTAALGLAQLVFLLGINQAD--LPFACTVIAILLHF 2448
Query: 5980 LYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQS 6039
LYLC FSW L+++++ + L + +++L WG+PAF+ L + G+ +
Sbjct: 2449 LYLCTFSWALLEALHLYRALTEVRDVNTGPMRFYYMLGWGVPAFITGLAV----GLDPEG 2504
Query: 6040 MSQIYGLIHGDLCFIPNVYAALFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGR 6099
YG + D C++ ++Y L + P+ V VF++ + A F +
Sbjct: 2505 ----YG--NPDFCWL-SIYDTLIWSFAGPV-AFAVSMSVFLYILAARASCAAQRQGFEKK 2556
Query: 6100 TNAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQM 6159
+ + + L+S TWL L + LF N +QG ++F+ Y +L ++
Sbjct: 2557 GPVSGLQPSFAVLLLLSATWLLALLSVNSDTLLFHYLFATCNCIQGPFIFLSYVVLSKEV 2616
Query: 6160 CCPMKASYTVEMNGHPG---PSTAFFTPGSGMPPAGGEISKSTQNLIGAMEEVPPDWERA 6216
+K + + + + P ST + P A G + + + G++
Sbjct: 2617 RKALKLACSRKPSPDPALTTKSTLTSSYNCPSPYADGRLYQPYGDSAGSLH--------- 2667
Query: 6217 SFQQGSQASPDLKP--SPQNGATFPSSGGYG---QGSLIADEESQEFDDLIFALKTGAGL 6271
S + ++ P P + A P G G GSL + + Q+ D + + L
Sbjct: 2668 STSRSGKSQPSYIPFLLREESALNPGQGPPGLGDPGSLFLEGQDQQHDP---DTDSDSDL 2724
Query: 6272 SVSDNESG 6279
S+ D++SG
Sbjct: 2725 SLEDDQSG 2732
>gi|59710093 G-protein coupled receptor 112 [Homo sapiens]
Length = 3080
Score = 94.0 bits (232), Expect = 4e-18
Identities = 84/319 (26%), Positives = 143/319 (44%), Gaps = 33/319 (10%)
Query: 5856 CLLW----NQAAASWLSDSQFCKVVEETADYVECACSHMSVYAVY-----ARTDNLSSYN 5906
C W N W +S CKV E +Y C C H++ + V + D+++
Sbjct: 2685 CAFWDFENNNGLGGW--NSSGCKVKETNVNYTICQCDHLTHFGVLMDLSRSTVDSVNEQI 2742
Query: 5907 EAFFTSGFICISGLCLAVLSHIFCARYSM---FAAKLLTHMMAASLGTQILFLASAYASP 5963
A T IS + L V + A + + + AK+L ++ A L ++FL +++ S
Sbjct: 2743 LALITYTGCGISSIFLGVAVVTYIAFHKLRKDYPAKILINLCTALLMLNLVFLINSWLSS 2802
Query: 5964 QLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL-FFLLSWGLPA 6022
C A HY L F+WM +++V+ + LV Y+L F L+ WG+PA
Sbjct: 2803 FQKVGVCITAAVALHYFLLVSFTWMGLEAVHMYLALVKVFNIYIPNYILKFCLVGWGIPA 2862
Query: 6023 FVVILLIVILKGIYHQ-SMSQIYGLIHGDLCFIPNVYAALFTAALVPLTCLVVVFVVFIH 6081
+V + + + K +Y S + + I D F +V A L+ L L + V +
Sbjct: 2863 IMVAITVSVKKDLYGTLSPTTPFCWIKDDSIFYISVVAYF---CLIFLMNLSMFCTVLVQ 2919
Query: 6082 AYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTW-----LWGGLHMAYRHFWMLVL 6136
VK Q + R + ++ + L L+ +TW WG + R+F+ L L
Sbjct: 2920 LNSVKSQIQK----TRRKMILHDLKGTMSLTFLLGLTWGFAFFAWGPM----RNFF-LYL 2970
Query: 6137 FVIFNSLQGLYVFMVYFIL 6155
F IFN+LQG ++F+ + ++
Sbjct: 2971 FAIFNTLQGFFIFVFHCVM 2989
>gi|119943125 G protein-coupled receptor 64 isoform 3 [Homo sapiens]
Length = 995
Score = 93.6 bits (231), Expect = 6e-18
Identities = 103/412 (25%), Positives = 178/412 (43%), Gaps = 47/412 (11%)
Query: 5771 IRIPERLLDVQDAEIMAGKSTCKLVQFTEYSSQQWFISGNNLPTLKNKVLSLSVKGQSSQ 5830
I +P L++ A M S VQF + + F P+L+N L V S
Sbjct: 467 ITLPSSLMNNLPAHDMELASR---VQFNFFETPALFQD----PSLENLSLISYVISSSVA 519
Query: 5831 LLTNDN---EVLYRIYAAEPRIIPQTSLCLLW----NQAAASWLSDSQFCKVVEETADYV 5883
LT N V + P T C+ W N W + C V + +
Sbjct: 520 NLTVRNLTRNVTVTLKHINPSQDELTVRCVFWDLGRNGGRGGWSDNG--CSVKDRRLNET 577
Query: 5884 ECACSHMSVYAVY---ARTDNLSSYNEA--FFTSGFICISGLCLAVLSHIFCARYSM--- 5935
C CSH++ + V +RT L + A F T +S + L+V + A +
Sbjct: 578 ICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRD 637
Query: 5936 FAAKLLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNF 5995
+ +K+L + AA L ++FL ++ + + C ++A HY L F+WM +++ +
Sbjct: 638 YPSKILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHM 697
Query: 5996 WYVLVMNDEHTERRYLL-FFLLSWGLPAFVVILLIVILKGIYH-QSMSQIYGLIHGDLCF 6053
+ LV R+Y+L F ++ WG+PA VV +++ I Y S + D C+
Sbjct: 698 YLALVKVFNTYIRKYILKFCIVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCW 757
Query: 6054 IPNVYAALFTAALVPLTCLV------VVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPL 6107
I N A+F +V C++ + VV + ++K K + +T+ ++
Sbjct: 758 INN--NAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIK---KKKQLGAQRKTSIQDLRS 812
Query: 6108 ILYLFALISVTW-----LWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFI 6154
I L L+ +TW WG +++ + + LF IFN+LQG ++F+ Y +
Sbjct: 813 IAGLTFLLGITWGFAFFAWGPVNVTF-----MYLFAIFNTLQGFFIFIFYCV 859
>gi|119943116 G protein-coupled receptor 64 isoform 2 [Homo sapiens]
Length = 1003
Score = 93.6 bits (231), Expect = 6e-18
Identities = 103/412 (25%), Positives = 178/412 (43%), Gaps = 47/412 (11%)
Query: 5771 IRIPERLLDVQDAEIMAGKSTCKLVQFTEYSSQQWFISGNNLPTLKNKVLSLSVKGQSSQ 5830
I +P L++ A M S VQF + + F P+L+N L V S
Sbjct: 475 ITLPSSLMNNLPAHDMELASR---VQFNFFETPALFQD----PSLENLSLISYVISSSVA 527
Query: 5831 LLTNDN---EVLYRIYAAEPRIIPQTSLCLLW----NQAAASWLSDSQFCKVVEETADYV 5883
LT N V + P T C+ W N W + C V + +
Sbjct: 528 NLTVRNLTRNVTVTLKHINPSQDELTVRCVFWDLGRNGGRGGWSDNG--CSVKDRRLNET 585
Query: 5884 ECACSHMSVYAVY---ARTDNLSSYNEA--FFTSGFICISGLCLAVLSHIFCARYSM--- 5935
C CSH++ + V +RT L + A F T +S + L+V + A +
Sbjct: 586 ICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRD 645
Query: 5936 FAAKLLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNF 5995
+ +K+L + AA L ++FL ++ + + C ++A HY L F+WM +++ +
Sbjct: 646 YPSKILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHM 705
Query: 5996 WYVLVMNDEHTERRYLL-FFLLSWGLPAFVVILLIVILKGIYH-QSMSQIYGLIHGDLCF 6053
+ LV R+Y+L F ++ WG+PA VV +++ I Y S + D C+
Sbjct: 706 YLALVKVFNTYIRKYILKFCIVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCW 765
Query: 6054 IPNVYAALFTAALVPLTCLV------VVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPL 6107
I N A+F +V C++ + VV + ++K K + +T+ ++
Sbjct: 766 INN--NAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIK---KKKQLGAQRKTSIQDLRS 820
Query: 6108 ILYLFALISVTW-----LWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFI 6154
I L L+ +TW WG +++ + + LF IFN+LQG ++F+ Y +
Sbjct: 821 IAGLTFLLGITWGFAFFAWGPVNVTF-----MYLFAIFNTLQGFFIFIFYCV 867
>gi|119943120 G protein-coupled receptor 64 isoform 1 [Homo sapiens]
Length = 1017
Score = 93.6 bits (231), Expect = 6e-18
Identities = 103/412 (25%), Positives = 178/412 (43%), Gaps = 47/412 (11%)
Query: 5771 IRIPERLLDVQDAEIMAGKSTCKLVQFTEYSSQQWFISGNNLPTLKNKVLSLSVKGQSSQ 5830
I +P L++ A M S VQF + + F P+L+N L V S
Sbjct: 489 ITLPSSLMNNLPAHDMELASR---VQFNFFETPALFQD----PSLENLSLISYVISSSVA 541
Query: 5831 LLTNDN---EVLYRIYAAEPRIIPQTSLCLLW----NQAAASWLSDSQFCKVVEETADYV 5883
LT N V + P T C+ W N W + C V + +
Sbjct: 542 NLTVRNLTRNVTVTLKHINPSQDELTVRCVFWDLGRNGGRGGWSDNG--CSVKDRRLNET 599
Query: 5884 ECACSHMSVYAVY---ARTDNLSSYNEA--FFTSGFICISGLCLAVLSHIFCARYSM--- 5935
C CSH++ + V +RT L + A F T +S + L+V + A +
Sbjct: 600 ICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRD 659
Query: 5936 FAAKLLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNF 5995
+ +K+L + AA L ++FL ++ + + C ++A HY L F+WM +++ +
Sbjct: 660 YPSKILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHM 719
Query: 5996 WYVLVMNDEHTERRYLL-FFLLSWGLPAFVVILLIVILKGIYH-QSMSQIYGLIHGDLCF 6053
+ LV R+Y+L F ++ WG+PA VV +++ I Y S + D C+
Sbjct: 720 YLALVKVFNTYIRKYILKFCIVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCW 779
Query: 6054 IPNVYAALFTAALVPLTCLV------VVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPL 6107
I N A+F +V C++ + VV + ++K K + +T+ ++
Sbjct: 780 INN--NAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIK---KKKQLGAQRKTSIQDLRS 834
Query: 6108 ILYLFALISVTW-----LWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFI 6154
I L L+ +TW WG +++ + + LF IFN+LQG ++F+ Y +
Sbjct: 835 IAGLTFLLGITWGFAFFAWGPVNVTF-----MYLFAIFNTLQGFFIFIFYCV 881
>gi|119943129 G protein-coupled receptor 64 isoform 4 [Homo sapiens]
Length = 1014
Score = 93.6 bits (231), Expect = 6e-18
Identities = 103/412 (25%), Positives = 178/412 (43%), Gaps = 47/412 (11%)
Query: 5771 IRIPERLLDVQDAEIMAGKSTCKLVQFTEYSSQQWFISGNNLPTLKNKVLSLSVKGQSSQ 5830
I +P L++ A M S VQF + + F P+L+N L V S
Sbjct: 486 ITLPSSLMNNLPAHDMELASR---VQFNFFETPALFQD----PSLENLSLISYVISSSVA 538
Query: 5831 LLTNDN---EVLYRIYAAEPRIIPQTSLCLLW----NQAAASWLSDSQFCKVVEETADYV 5883
LT N V + P T C+ W N W + C V + +
Sbjct: 539 NLTVRNLTRNVTVTLKHINPSQDELTVRCVFWDLGRNGGRGGWSDNG--CSVKDRRLNET 596
Query: 5884 ECACSHMSVYAVY---ARTDNLSSYNEA--FFTSGFICISGLCLAVLSHIFCARYSM--- 5935
C CSH++ + V +RT L + A F T +S + L+V + A +
Sbjct: 597 ICTCSHLTSFGVLLDLSRTSVLPAQMMALTFITYIGCGLSSIFLSVTLVTYIAFEKIRRD 656
Query: 5936 FAAKLLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNF 5995
+ +K+L + AA L ++FL ++ + + C ++A HY L F+WM +++ +
Sbjct: 657 YPSKILIQLCAALLLLNLVFLLDSWIALYKMQGLCISVAVFLHYFLLVSFTWMGLEAFHM 716
Query: 5996 WYVLVMNDEHTERRYLL-FFLLSWGLPAFVVILLIVILKGIYH-QSMSQIYGLIHGDLCF 6053
+ LV R+Y+L F ++ WG+PA VV +++ I Y S + D C+
Sbjct: 717 YLALVKVFNTYIRKYILKFCIVGWGVPAVVVTIILTISPDNYGLGSYGKFPNGSPDDFCW 776
Query: 6054 IPNVYAALFTAALVPLTCLV------VVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPL 6107
I N A+F +V C++ + VV + ++K K + +T+ ++
Sbjct: 777 INN--NAVFYITVVGYFCVIFLLNVSMFIVVLVQLCRIK---KKKQLGAQRKTSIQDLRS 831
Query: 6108 ILYLFALISVTW-----LWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFI 6154
I L L+ +TW WG +++ + + LF IFN+LQG ++F+ Y +
Sbjct: 832 IAGLTFLLGITWGFAFFAWGPVNVTF-----MYLFAIFNTLQGFFIFIFYCV 878
>gi|6912464 latrophilin 2 precursor [Homo sapiens]
Length = 1403
Score = 93.2 bits (230), Expect = 7e-18
Identities = 85/369 (23%), Positives = 156/369 (42%), Gaps = 32/369 (8%)
Query: 5806 FISGNNLPTLKNKVLSLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTSL---CLLWNQA 5862
FI N+ + + V+S+S+ +SS++ D VL+ + P I P C WN +
Sbjct: 727 FIGRNSTIAVNSHVISVSINKESSRVYLTD-PVLFTL----PHIDPDNYFNANCSFWNYS 781
Query: 5863 AASWLS--DSQFCKVVEETADYVECACSHMSVYAVY------ARTDNLSSYNEAFFTSGF 5914
+ + +Q CK+V+ CACSH++ +A+ A D + T
Sbjct: 782 ERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKDGVHELLLTVITWVG 841
Query: 5915 ICISGLCLAVLSHIFCARYSMFAAKLLTH--MMAASLGTQILFLASAYASPQLAEESCSA 5972
I IS +CLA+ FC + + + H + + +FL + +C
Sbjct: 842 IVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTKYAI--ACPI 899
Query: 5973 MAAVTHYLYLCQFSWMLIQSVNFWYVL--VMNDEHTERRYLLFFLLSWGLPAFVVILLIV 6030
A + H+ +L F+WM ++ V + +L V E++ ++Y +++ + PA VV
Sbjct: 900 FAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKY--YYVAGYLFPATVV----- 952
Query: 6031 ILKGIYHQSMSQIYGLIHGDLCFIPNVYAALFTAALVPLTCLVVVFVVFIHAYQVKPQWK 6090
G+ + YG + N + F + + L ++F+V VK
Sbjct: 953 ---GVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHSNT 1009
Query: 6091 AYDDVFRGRTNAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFM 6150
D R + + L L+ +TW +G L + M LF IFN+ QG+++F+
Sbjct: 1010 LKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFIFI 1069
Query: 6151 VYFILHNQM 6159
+ L ++
Sbjct: 1070 FHCALQKKV 1078
>gi|163792198 latrophilin 3 precursor [Homo sapiens]
Length = 1469
Score = 92.8 bits (229), Expect = 1e-17
Identities = 104/475 (21%), Positives = 204/475 (42%), Gaps = 81/475 (17%)
Query: 5835 DNEVLYRIYAAEPRIIPQTSL----------CLLWNQAAASWLS--DSQFCKVVEETADY 5882
+ E ++Y A+P + + C W+ + + +Q C+++ +
Sbjct: 787 NKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTH 846
Query: 5883 VECACSHMSVYAVYA------RTDNLSSYNEAFFTSGFICISGLCLAVLSHIFCARYSMF 5936
C+C+H++ +AV +D + T I +S +CL + FC +
Sbjct: 847 TTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQ 906
Query: 5937 AAKLLTH--MMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVN 5994
+ + H + + ++LFL + Q +C+ AA+ H+ +L F+WM ++ V
Sbjct: 907 SDRNTIHKNLCISLFVAELLFLIGINRTDQPI--ACAVFAALLHFFFLAAFTWMFLEGVQ 964
Query: 5995 FWYVL--VMNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLC 6052
+ +L V EH+ R+Y F+L+ +G+PA L++ + + ++S YG +C
Sbjct: 965 LYIMLVEVFESEHSRRKY--FYLVGYGMPA----LIVAVSAAVDYRS----YGT--DKVC 1012
Query: 6053 FIPNVYAALFTAALVPLTCLVVVFVVFI---------HAYQVKPQWKAYDDV-FRGRTNA 6102
++ + + + P T ++++ V+F+ H +KP+ D++ +
Sbjct: 1013 WL-RLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPF 1071
Query: 6103 AEIPLI--LYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQM- 6159
+ +I + L L+ +TW +G +++ M LF IFNSLQG+++F+ + +L ++
Sbjct: 1072 IKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVR 1131
Query: 6160 ----------CCPMKASYTVEMNGHPGPSTAFFTPGSGMPPAGGEISKSTQNLIGAM-EE 6208
CC K++ + +G T GS P G S +Q+ I M +
Sbjct: 1132 KEYGKCLRTHCCSGKSTESSIGSGK--------TSGSRTP---GRYSTGSQSRIRRMWND 1180
Query: 6209 VPPDWERASFQQG---SQASPDLKPSPQNGA------TFPSSGGYGQGSLIADEE 6254
+SF G S AS + + N T P +G +G IA E
Sbjct: 1181 TVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLNGNHGNSYSIASGE 1235
>gi|57165355 latrophilin 1 isoform 1 precursor [Homo sapiens]
Length = 1474
Score = 90.1 bits (222), Expect = 6e-17
Identities = 87/355 (24%), Positives = 155/355 (43%), Gaps = 23/355 (6%)
Query: 5815 LKNKVLSLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTSLCLLWNQAAASWLS--DSQF 5872
+ ++V++ S+ +SS++ D V++ + E + + C WN + S L +Q
Sbjct: 763 VNSQVIAASINKESSRVFLMD-PVIFTVAHLEDKNHFNAN-CSFWNYSERSMLGYWSTQG 820
Query: 5873 CKVVEETADYVECACSHMSVYAVYARTDNL--SSYNE---AFFTSGFICISGLCLAVLSH 5927
C++VE + CACSH++ +AV + NE + T I IS +CLA+
Sbjct: 821 CRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICIS 880
Query: 5928 IFCARYSMFAAKLLTH--MMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQF 5985
FC + + H + ++LFL + E +C A + HY +L F
Sbjct: 881 TFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKTQY--EIACPIFAGLLHYFFLAAF 938
Query: 5986 SWMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYG 6045
SW+ ++ V+ + +LV E R ++L + PA VV + I Y ++
Sbjct: 939 SWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAI---DYRSYGTEKAC 995
Query: 6046 LIHGDLCFIPNVYAALFTAALVPLTCLVVVFVVFIHAYQV-KPQWKAYDDVFRGRTNAAE 6104
+ D FI + + +V L L+V I + V KP D++ A
Sbjct: 996 WLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGA-- 1053
Query: 6105 IPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQM 6159
+ L L+ +TW +G L + M LF FN+ QG+++F+ + L ++
Sbjct: 1054 ----IALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKV 1104
>gi|41281557 latrophilin 1 isoform 2 precursor [Homo sapiens]
Length = 1469
Score = 90.1 bits (222), Expect = 6e-17
Identities = 87/355 (24%), Positives = 155/355 (43%), Gaps = 23/355 (6%)
Query: 5815 LKNKVLSLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTSLCLLWNQAAASWLS--DSQF 5872
+ ++V++ S+ +SS++ D V++ + E + + C WN + S L +Q
Sbjct: 758 VNSQVIAASINKESSRVFLMD-PVIFTVAHLEDKNHFNAN-CSFWNYSERSMLGYWSTQG 815
Query: 5873 CKVVEETADYVECACSHMSVYAVYARTDNL--SSYNE---AFFTSGFICISGLCLAVLSH 5927
C++VE + CACSH++ +AV + NE + T I IS +CLA+
Sbjct: 816 CRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICIS 875
Query: 5928 IFCARYSMFAAKLLTH--MMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYLCQF 5985
FC + + H + ++LFL + E +C A + HY +L F
Sbjct: 876 TFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKTQY--EIACPIFAGLLHYFFLAAF 933
Query: 5986 SWMLIQSVNFWYVLVMNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYG 6045
SW+ ++ V+ + +LV E R ++L + PA VV + I Y ++
Sbjct: 934 SWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAI---DYRSYGTEKAC 990
Query: 6046 LIHGDLCFIPNVYAALFTAALVPLTCLVVVFVVFIHAYQV-KPQWKAYDDVFRGRTNAAE 6104
+ D FI + + +V L L+V I + V KP D++ A
Sbjct: 991 WLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGA-- 1048
Query: 6105 IPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQM 6159
+ L L+ +TW +G L + M LF FN+ QG+++F+ + L ++
Sbjct: 1049 ----IALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKV 1099
>gi|238859647 G protein-coupled receptor 128 [Homo sapiens]
Length = 797
Score = 87.8 bits (216), Expect = 3e-16
Identities = 74/342 (21%), Positives = 149/342 (43%), Gaps = 45/342 (13%)
Query: 5856 CLLWNQAAASWLSDSQFCKVVEETADYVECACSHMSVYAVYARTDNLSSYNEAF-FTSGF 5914
C+ WN +A W D+ C+ + T ++ C C+H + +AV Y ++ S
Sbjct: 383 CVYWNLSAKDW--DTYGCQKDKGTDGFLRCRCNHTTNFAVLMTFKKDYQYPKSLDILSNV 440
Query: 5915 IC---ISGLCLAVLSHIFCARYSMFAAK-LLTHMMAASLGTQILFLASAYASPQLAEES- 5969
C ++GL L V+ I + + +L ++ + L +LF+ S + + S
Sbjct: 441 GCALSVTGLALTVIFQIVTRKVRKTSVTWVLVNLCISMLIFNLLFVFGIENSNKNLQTSD 500
Query: 5970 -------------------------CSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDE 6004
C+A+AA+ HY L F+W + + +Y+L+ +
Sbjct: 501 GDINNIDFDNNDIPRTDTINIPNPMCTAIAALLHYFLLVTFTWNALSAAQLYYLLIRTMK 560
Query: 6005 HTERRYLLFF-LLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLCFI----PN--V 6057
R ++LF L+ WG+PA VV + + ++ + +C++ PN +
Sbjct: 561 PLPRHFILFISLIGWGVPAIVVAITVGVIYSQNGNNPQWELDYRQEKICWLAIPEPNGVI 620
Query: 6058 YAALFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGR--TNAAEIPLILYLFALI 6115
+ L + +VP+T +++ VV +K WK ++ + ++ +I L + +
Sbjct: 621 KSPLLWSFIVPVTIILISNVVMFITISIKVLWKNNQNLTSTKKVSSMKKIVSTLSVAVVF 680
Query: 6116 SVTWLWGGLHMAYRHFWMLV---LFVIFNSLQGLYVFMVYFI 6154
+TW+ L + +V +F +FN+ QGL +F++Y +
Sbjct: 681 GITWILAYLMLVNDDSIRIVFSYIFCLFNTTQGLQIFILYTV 722
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 87.0 bits (214), Expect = 5e-16
Identities = 71/270 (26%), Positives = 122/270 (45%), Gaps = 22/270 (8%)
Query: 4258 TVVASDSPYGRFAFSHEQLRVSE-AQRVNITIIRSSGDFGH-VRLWYKTMSGTAEAGLDF 4315
T V + P + F + E V +TIIR GD + V + ++T GTA AG D+
Sbjct: 398 TEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDY 457
Query: 4316 VPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQID 4375
G ++F+ G+ +K + V I+DDD E E F + ++ V++ + I E +
Sbjct: 458 EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEAN-HVS 516
Query: 4376 QPPEIGNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTAD 4435
+G+ S + I +D+A GI F+ T V E +G++ + V+R G G V
Sbjct: 517 TLACLGSPSTATVTIFDDDHA-GIFTFEEPVT--HVSESIGIMEVKVLRTSGARGNVIVP 573
Query: 4436 FISQSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNE----------------SE 4479
+ + +A GG D+ + FQ+ + + I++ +IDD E E
Sbjct: 574 YKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVE 633
Query: 4480 FEEPIEILLTGATGGAVLGRHLVSRIIIAK 4509
E +LL G + G++L + + K
Sbjct: 634 MSEKKALLLNELGGFTITGKYLFGQPVFRK 663
Score = 77.0 bits (188), Expect = 5e-13
Identities = 67/223 (30%), Positives = 103/223 (46%), Gaps = 21/223 (9%)
Query: 1734 EEDGEIRLLVIRAQG-LLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792
E G + L +IR G L V +FRT TA + DY+ GT+ F+PG+ K I + I
Sbjct: 420 ENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGI 479
Query: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQILV 1852
D+ I E +++F V L N+ +V S DG +E + A LG S V
Sbjct: 480 IDDDIFEEDENFLVHLSNV--------KVSSEASEDGILE--ANHVSTLACLGSPSTATV 529
Query: 1853 TIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPDG 1911
TI DHA G+F F VS + + + V+R G V + + I+ G
Sbjct: 530 TIFDDDHA-GIFTFEEPVTHVS-----ESIGIMEVKVLRTSGARGNVIVPYKTIEGTARG 583
Query: 1912 ---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSV 1951
D T G + F+ + I+V+++ DE+ E +K F + +
Sbjct: 584 GGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 73.9 bits (180), Expect = 5e-12
Identities = 65/223 (29%), Positives = 96/223 (43%), Gaps = 27/223 (12%)
Query: 35 FTGQTEFVVNETSTTVIRLIIERIGEPANVTAIVSLYGEDA-----GDFFDTYAAAFIPA 89
F Q + E TV II R G+ N T V ED D+ T
Sbjct: 410 FFEQGTYQCLENCGTVALTIIRRGGDLTN-TVFVDFRTEDGTANAGSDYEFTEGTVVFKP 468
Query: 90 GETNRTVYIAVCDDDLPEPDETFIFHLTLQKPSANVK---------------LGWPRTVT 134
G+T + + + + DDD+ E DE F+ HL+ K S+ LG P T T
Sbjct: 469 GDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTAT 528
Query: 135 VTILSNDNAFGIISFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNP 193
VTI +D+A GI +F P VSE G M + ++R G G V+V ++ +EG
Sbjct: 529 VTIFDDDHA-GIFTFEE-PVTHVSESIG---IMEVKVLRTSGARGNVIVPYKTIEGTARG 583
Query: 194 PDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQL 236
ED G + F ++ V+DDE E ++ F +++
Sbjct: 584 GGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 72.0 bits (175), Expect = 2e-11
Identities = 65/230 (28%), Positives = 103/230 (44%), Gaps = 40/230 (17%)
Query: 3793 ENTTTLQLQIARDKG-LLGDIAIHLRAQPNFLLHVDNQATENEDYVLQETIIIMKENIKE 3851
EN T+ L I R G L + + R + D A DY E ++ K +
Sbjct: 420 ENCGTVALTIIRRGGDLTNTVFVDFRTE-------DGTANAGSDYEFTEGTVVFKPGDTQ 472
Query: 3852 AHAEVSILPDDLPELEEGFIVTIT--------------EVNLVNSDFSTGQPSVRRPGME 3897
V I+ DD+ E +E F+V ++ E N V++ G PS
Sbjct: 473 KEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPST------ 526
Query: 3898 IAEIMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGAVNVYWKA 3957
A + I + DD GIF F E +T V + +++V V+R +G+ G V V +K
Sbjct: 527 -ATVTIFD-DDHAGIFTFE------EPVT--HVSESIGIMEVKVLRTSGARGNVIVPYKT 576
Query: 3958 SPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISL 4005
+A G EDF+ + G LEF + ++ I + +IDD E+E +TF + +
Sbjct: 577 IEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 71.6 bits (174), Expect = 2e-11
Identities = 62/232 (26%), Positives = 106/232 (45%), Gaps = 38/232 (16%)
Query: 1884 TVTLNVIRHHGTLS-PVTLHWNID---SDPDGDLAFTSGNITFEIGQTSANITVEILPDE 1939
TV L +IR G L+ V + + + ++ D FT G + F+ G T I V I+ D+
Sbjct: 424 TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
Query: 1940 DPELDKAFSVSVLSVSSGS------------------LGAHINATLTVLASDDPYGIFIF 1981
E D+ F V + +V S LG+ AT+T+ DD GIF F
Sbjct: 484 IFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIF-DDDHAGIFTF 542
Query: 1982 SEKNRPVK-VEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDY 2040
E PV V E+ + + ++R G G V+V Y T++ + G D+
Sbjct: 543 EE---PVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG-----------GEDF 588
Query: 2041 IPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSI 2092
G F ++ TI++ ++DD+E E++++ F+E+ LV + +++
Sbjct: 589 EDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKAL 640
Score = 70.9 bits (172), Expect = 4e-11
Identities = 70/245 (28%), Positives = 106/245 (43%), Gaps = 38/245 (15%)
Query: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISAS- 2553
G A AGSDYE T + + GD + V I+ DD E DE+FL VHL N+ S
Sbjct: 449 GTANAGSDYE-FTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFL-----VHLSNVKVSS 502
Query: 2554 ------------LKNQPTIGQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQ 2601
+ +G P+ +TV I + D G+F + SE
Sbjct: 503 EASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAGIFTFEEPVTHVSES--------- 552
Query: 2602 PQTLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTIL 2660
++E+ + RT G+ G V V ++ + GTA G DF L F E KT+ + ++
Sbjct: 553 -IGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVI 611
Query: 2661 DDSEPEDDESIIVSLVYTEGGSRILPSSD--TVRVNILANDNVAGIVSF-QTASRSVIGH 2717
DD E E +++ + + G R++ S+ + +N L + G F Q R V
Sbjct: 612 DDEEYEKNKTFFLEI----GEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAR 667
Query: 2718 EGEIL 2722
E IL
Sbjct: 668 EHPIL 672
Score = 69.3 bits (168), Expect = 1e-10
Identities = 79/297 (26%), Positives = 123/297 (41%), Gaps = 42/297 (14%)
Query: 1968 TVLASDDPYGIFIFSEKNRPVKVEEATQNITLSIIRLKG-LMGKVLVSYATLDDMEKPPY 2026
T + +DP F + + E + L+IIR G L V V + T D
Sbjct: 398 TEVTENDPVSKIFFEQGT--YQCLENCGTVALTIIRRGGDLTNTVFVDFRTED------- 448
Query: 2027 FPPNLARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAK 2086
A G DY G +F ++ I + I+DDD E E+ + L N K
Sbjct: 449 -----GTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSN----VK 499
Query: 2087 VQSRSIPNSPRLGPKVETIAQL-------IIIANDDAFGTLQLSAPIVRVAENHVGPIIN 2139
V S + + V T+A L + I +DD G P+ V+E+ +
Sbjct: 500 VSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVK 559
Query: 2140 VTRTGGAFADVSVKFKAVPITAI-AGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELE 2198
V RT GA +V V +K + TA GED+ ++ E K + + VI+D E
Sbjct: 560 VLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKN 619
Query: 2199 ESFLVQLMNETTGGARLGALTE--AVIIIEASDDPYGLFGFQIT-KLIVEEPEFNSV 2252
++F +++ G RL ++E A+++ E L GF IT K + +P F V
Sbjct: 620 KTFFLEI-----GEPRLVEMSEKKALLLNE-------LGGFTITGKYLFGQPVFRKV 664
Score = 65.9 bits (159), Expect = 1e-09
Identities = 60/200 (30%), Positives = 92/200 (46%), Gaps = 22/200 (11%)
Query: 2606 VELMIHRTGGSL-GQVAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664
V L I R GG L V V++R GTA G D+ + F G+T+K + + I+DD
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 2665 PEDDESIIVSLVYTEGGSR----------------ILPSSDTVRVNILANDNVAGIVSFQ 2708
E+DE+ +V L + S L S T V I +D+ AGI +F+
Sbjct: 485 FEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDH-AGIFTFE 543
Query: 2709 TASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKII---GQNLELNFANFSGQLFFPEGSL 2765
V G I++ V+RT RGNV V +K I + +F + G+L F +
Sbjct: 544 EPVTHVSESIG-IMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEI 602
Query: 2766 NTTLFVHLLDDNIPEEKEVY 2785
T+ V ++DD E+ + +
Sbjct: 603 VKTISVKVIDDEEYEKNKTF 622
Score = 64.7 bits (156), Expect = 3e-09
Identities = 60/228 (26%), Positives = 94/228 (41%), Gaps = 27/228 (11%)
Query: 1587 EEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLN 1646
E T++ + R G D + + + E DG D+ GT+ F P + +
Sbjct: 420 ENCGTVALTIIRRGG--DLTNTVFVDFRTE-DGTANAGSDYEFTEGTVVFKPGDTQKEIR 476
Query: 1647 IYVLDDDIPELNEYF-----RVTLVSAIPGDGKLGSTPTSGASIDPEKETTDITIKASDH 1701
+ ++DDDI E +E F V + S DG L + S + T +TI DH
Sbjct: 477 VGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDH 536
Query: 1702 PYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVS 1761
G+ F P V E G + + V+R G G V ++T+
Sbjct: 537 A-GIFTFEE-----------------PVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIE 578
Query: 1762 LTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVEL 1808
TA ED+++ G LEFQ E K I + + D+ E K+F +E+
Sbjct: 579 GTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 63.9 bits (154), Expect = 5e-09
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 37/248 (14%)
Query: 2138 INVTRTGGAFAD-VSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPE 2196
+ + R GG + V V F+ TA AG DY VV G+T K + + +I+D E
Sbjct: 427 LTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFE 486
Query: 2197 LEESFLVQLMNETTGG----------------ARLGALTEAVIIIEASDDPYGLFGFQIT 2240
+E+FLV L N A LG+ + A + I DD G+F F+
Sbjct: 487 EDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAGIFTFEEP 545
Query: 2241 KLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVVSGNVTFAPG 2297
V E S+ + + ++R SG GNV V + TI G G D G + F
Sbjct: 546 VTHVSE----SIGIMEVKVLRTSGARGNVIVPY-KTIEGTARGGGEDFEDTCGELEFQND 600
Query: 2298 ETIQTLLLEVLADDVPE-----IEEVIQVQLTDASGGGTIGLDRIANIIIPANDDPYGTV 2352
E ++T+ ++V+ D+ E E+ + +L + S + L+ + I G
Sbjct: 601 EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTIT------GKY 654
Query: 2353 AFAQMVYR 2360
F Q V+R
Sbjct: 655 LFGQPVFR 662
Score = 62.8 bits (151), Expect = 1e-08
Identities = 59/209 (28%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 1017 GETANFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFV 1076
G A + R G + T V + T+DG A A D+ E T++F+ G Q+ I + +
Sbjct: 423 GTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS-DYEFTE--GTVVFKPGDTQKEIRVGI 479
Query: 1077 NEDGIPETDEPFYIILLNSTGDTVVYQYGV-----------------ATVIIEANDDPNG 1119
+D I E DE F + L N + + G+ ATV I +DD G
Sbjct: 480 IDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAG 538
Query: 1120 IFSL-EPIDKAVEEGKTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNF 1178
IF+ EP+ E +LR G G+V V ++ + +A G++F +T G + F
Sbjct: 539 IFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEG-TARGGGEDFEDTCGELEF 597
Query: 1179 MDGEEAKPIILHAFPDKIPEFNEFYFLKL 1207
+ E K I + D+ E N+ +FL++
Sbjct: 598 QNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 60.8 bits (146), Expect = 4e-08
Identities = 52/221 (23%), Positives = 93/221 (42%), Gaps = 8/221 (3%)
Query: 2962 IEWQQSRFEVNETHGSLTL-VAQRSREPLGHVSLFVYAQNLEAQVGLDYIFTPMILHFAD 3020
I ++Q ++ E G++ L + +R + V + ++ A G DY FT + F
Sbjct: 409 IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKP 468
Query: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNPSPGLE------LGKNTIALIIVLANDDGPG 3074
G+ K + + I+DDDI E DE F + L+N E L N ++ + L +
Sbjct: 469 GDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTAT 528
Query: 3075 VLSFNNSE-HFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSSNESKDL 3133
V F++ F E +V ES+ ++ + G G V V + E + +D
Sbjct: 529 VTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDF 588
Query: 3134 TPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
+ G + + K + + I D E E ++ F + P
Sbjct: 589 EDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEP 629
Score = 58.5 bits (140), Expect = 2e-07
Identities = 44/164 (26%), Positives = 75/164 (45%), Gaps = 27/164 (16%)
Query: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAE----------- 3633
SD+ + G ++F+PG+ + I V I+DD + E++E+F V L N K +E
Sbjct: 455 SDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANH 514
Query: 3634 ------IGINDSVTITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGTYGR 3687
+G + T+TI +D A GI F + + E ++ + V R G G
Sbjct: 515 VSTLACLGSPSTATVTIFDDDHA-GIFTFEEPVTHVS----ESIGIMEVKVLRTSGARGN 569
Query: 3688 I-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILAD 3726
+ TI A G D T G + F +++ TI++ ++ D
Sbjct: 570 VIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDD 613
Score = 51.2 bits (121), Expect = 3e-05
Identities = 62/257 (24%), Positives = 105/257 (40%), Gaps = 39/257 (15%)
Query: 248 SRNSIEIIIKKND--SPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYEVSISY 305
S + + + +ND S + F Q Y E + + ++R + N + D
Sbjct: 392 SMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVD-------- 443
Query: 306 AVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKD 365
T + TA+A + +F + TVVF P + ++ I+DD I E E+F + L
Sbjct: 444 -FRTEDGTANAGSDYEFTE----GTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNV 498
Query: 366 TLQGD---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDR 410
+ + A L SPS VTI +D G+ + FE V +
Sbjct: 499 KVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHA-GIFT-----FEEPVTHVSES 552
Query: 411 ISRYEEITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLT 470
I E+ V+R G GNV + + D + G L F +++ TI +
Sbjct: 553 IG-IMEVKVLRTSGARGNVIVPYKTIEGTARGG--GEDFEDTCGELEFQNDEIVKTISVK 609
Query: 471 VVDDDLPEEAEAYLLQI 487
V+DD+ E+ + + L+I
Sbjct: 610 VIDDEEYEKNKTFFLEI 626
Score = 50.1 bits (118), Expect = 7e-05
Identities = 60/255 (23%), Positives = 102/255 (40%), Gaps = 39/255 (15%)
Query: 3903 IEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSF-GAVNVYWKASPDS 3961
+ END IF T Y+ + + ++R G V V ++ +
Sbjct: 400 VTENDPVSKIFFEQGT---------YQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGT 450
Query: 3962 AGL-EDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGGGRLGDDVVV 4020
A D++ + G + F I + IIDD FE E F + L +V +D ++
Sbjct: 451 ANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGIL 510
Query: 4021 -----------------TVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRS 4063
TV I +D G+F FEE + ES+ + + V+R+
Sbjct: 511 EANHVSTLACLGSPSTATVTIFDDDHA-GIFTFEEPVTHVSESI------GIMEVKVLRT 563
Query: 4064 PGGKGTVRLEW-TIDEKAK---HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFT 4119
G +G V + + TI+ A+ + G L F E KTI + + D E+++ F
Sbjct: 564 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFF 623
Query: 4120 IQLISIDEVEISPVK 4134
+++ VE+S K
Sbjct: 624 LEIGEPRLVEMSEKK 638
Score = 49.3 bits (116), Expect = 1e-04
Identities = 63/273 (23%), Positives = 113/273 (41%), Gaps = 28/273 (10%)
Query: 4409 FEVEEDVGLIMIPVVRLHGTY-GYVTADFISQSSSASPGGVDYILHGSTVTFQHGQNLSF 4467
++ E+ G + + ++R G V DF ++ +A+ G DY TV F+ G
Sbjct: 416 YQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS-DYEFTEGTVVFKPGDTQKE 474
Query: 4468 INISIIDDNESEFEEPIEILLTG------ATGGAVLGRHLVSRIIIAKSDSPFGVIRFLN 4521
I + IIDD+ E +E + L+ A+ +L + VS + S S V F +
Sbjct: 475 IRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDD 534
Query: 4522 QSK--ISIANP-----NSTMILSLVLERTGGLLGEIQVNWETVGPNSQEALLPQNRDIAD 4574
+ P S I+ + + RT G G + V ++T+ ++ D D
Sbjct: 535 DHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG----GEDFED 590
Query: 4575 PVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAKLDSRAKDVTLTIQE 4634
L + + + V+TI + + EE E +TF +++ GE +L ++ L + E
Sbjct: 591 TCGELEF--QNDEIVKTISVKVIDDEEYEKNKTFFLEI----GEPRLVEMSEKKALLLNE 644
Query: 4635 FGDPNGVVQFAPETLSKKTYSEPLALEGPLLIT 4667
G G + + + A E P+L T
Sbjct: 645 LG---GFTITGKYLFGQPVFRKVHAREHPILST 674
Score = 47.8 bits (112), Expect = 4e-04
Identities = 42/170 (24%), Positives = 78/170 (45%), Gaps = 12/170 (7%)
Query: 2891 GFLILEEGETAAAINITILEDDVPELEEYFLVNLTYV---------GLTMAASTSFPPRL 2941
G ++ + G+T I + I++DD+ E +E FLV+L+ V G+ A S L
Sbjct: 462 GTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACL 521
Query: 2942 DSEGLTAQVIIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQN 3000
S I D D G+ +++ V+E+ G + + R+ G+V + + +
Sbjct: 522 GSPSTATVTIFD--DDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEG 579
Query: 3001 LEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
G D+ T L F + E K +++ ++DD+ E ++ F L + P
Sbjct: 580 TARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEP 629
Score = 47.0 bits (110), Expect = 6e-04
Identities = 68/256 (26%), Positives = 105/256 (41%), Gaps = 45/256 (17%)
Query: 766 ILENDDPGGVFEFSPASRGPYVIKEG-ESVELHIIRSRGSLVKQ-FLHYRVEPRDSN--- 820
+ END +F +G Y E +V L IIR G L F+ +R E +N
Sbjct: 400 VTENDPVSKIF----FEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS 455
Query: 821 EFYGNTGVLEFKPGEREIVITLLARLDGIPELDEHYWVVLS----------------SHG 864
++ G + FKPG+ + I + D I E DE++ V LS +H
Sbjct: 456 DYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHV 515
Query: 865 ERESKLGSATIVNITILKNDDPHGIIEF------VSDGLIVM------INESKGDAI--Y 910
+ LGS + +TI +DD GI F VS+ + +M + ++G+ I Y
Sbjct: 516 STLACLGSPSTATVTIF-DDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPY 574
Query: 911 SAVYDVVRNRG-NFGDVSVSWVVSPDFTQDVFPVQGTVVFGDQEFSKNITIY-SLPDEIP 968
+ R G +F D D ++ V D+E+ KN T + + +
Sbjct: 575 KTIEGTARGGGEDFEDTCGELEFQND---EIVKTISVKVIDDEEYEKNKTFFLEIGEPRL 631
Query: 969 EEMEEFTVILLNGTGG 984
EM E +LLN GG
Sbjct: 632 VEMSEKKALLLNELGG 647
Score = 45.8 bits (107), Expect = 0.001
Identities = 48/176 (27%), Positives = 78/176 (44%), Gaps = 23/176 (13%)
Query: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558
A SD G + F+ G+T K + DD+ E +E F++ L +V + SE+
Sbjct: 453 AGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 1559 ------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTRGALDYV 1606
+TA +TI D+A G+F F + ++E + V RT GA V
Sbjct: 513 NHVSTLACLGSPSTATVTIFDDDHA-GIFTFEEP-VTHVSESIGIMEVKVLRTSGARGNV 570
Query: 1607 HVFY-TISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYF 1661
V Y TI G +DF + G + F + + +++ V+DD+ E N+ F
Sbjct: 571 IVPYKTIEGTARGG----GEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTF 622
Score = 43.9 bits (102), Expect = 0.005
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 1/80 (1%)
Query: 166 SMPLTLIREKGTY-GMVMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDE 224
++ LT+IR G V V F E G D +G + F PG + ++DD+
Sbjct: 424 TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
Query: 225 VPENDEIFLIQLKSVEGGAE 244
+ E DE FL+ L +V+ +E
Sbjct: 484 IFEEDENFLVHLSNVKVSSE 503
Score = 42.7 bits (99), Expect = 0.011
Identities = 53/207 (25%), Positives = 82/207 (39%), Gaps = 30/207 (14%)
Query: 5131 AGMDISFPETTVAVAVDTTLIPVETESTTYLSTSKTTTILQPTNVVAIVTEATGVSAIPE 5190
AG D F E TV T + + L + V + +EA+ +
Sbjct: 453 AGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 5191 KLVTLHGTPAVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTG 5249
V+ T A P ATVT H G F+ + ++ E + EV + RT
Sbjct: 513 NHVS---TLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESI-----GIMEVKVLRTS 564
Query: 5250 GFTGNVSITVKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERE 5309
G GNV + KT +E A RG EDFE+ L F + E
Sbjct: 565 GARGNVIVPYKT-------IEGTA---RG-----------GGEDFEDTCGELEFQNDEIV 603
Query: 5310 RKVSVQILDDDEPEGQEFFYVFLTNPQ 5336
+ +SV+++DD+E E + F++ + P+
Sbjct: 604 KTISVKVIDDEEYEKNKTFFLEIGEPR 630
Score = 38.9 bits (89), Expect = 0.16
Identities = 51/239 (21%), Positives = 103/239 (43%), Gaps = 34/239 (14%)
Query: 4020 VTVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGG-KGTVRLEWTIDE 4078
V + +ND +F FE+ T E+ + V LT++R G TV +++ ++
Sbjct: 396 VNTEVTENDPVSKIF-FEQGTYQCLENCGT------VALTIIRRGGDLTNTVFVDFRTED 448
Query: 4079 ---KAKHNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKG 4135
A + GT+ F ++QK I + + D + EED F L+ + V++S
Sbjct: 449 GTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENF---LVHLSNVKVSSEAS 505
Query: 4136 SASIIIRGDKRASGEVGIAPSSRHILI-----------GEPSAKYN---GTAIISLVRGP 4181
I+ +G +PS+ + I EP + G + ++R
Sbjct: 506 EDGILEANHVSTLACLG-SPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS 564
Query: 4182 GILGEVTVFWRIFPPSV----GEFAETSGKLTMRDEQSAVIVVIQALNDDIPEE-KSFY 4235
G G V V ++ + +F +T G+L ++++ + ++ ++D+ E+ K+F+
Sbjct: 565 GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFF 623
Score = 38.1 bits (87), Expect = 0.28
Identities = 59/240 (24%), Positives = 102/240 (42%), Gaps = 37/240 (15%)
Query: 4879 VSEKAANSQVGFESTAFQLMNITAGTSHVMISRRG--TYGALSVAWTT--GYAPGLEIPE 4934
V+E S++ FE +Q + GT + I RRG + V + T G A E
Sbjct: 400 VTENDPVSKIFFEQGTYQCLE-NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYE 458
Query: 4935 FIVVGNMTPTLGSLSFSHGEQRKGVFLWTFPSPGWPEA--FVLHLSGVQSSAPG------ 4986
F T G++ F G+ +K + + + E F++HLS V+ S+
Sbjct: 459 F--------TEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGIL 510
Query: 4987 -----------GAQLRSGFIVAEIEPMGVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHS 5035
G+ + + + + G+F F + VSE ++ + V R G
Sbjct: 511 EANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTH--VSESIGIMEVKVLRTSGARG 568
Query: 5036 DLIKVSYQTTAGSAKPL-EDFEPVQNGELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5094
++I V Y+T G+A+ EDFE GEL FQ + + +I+D+ E + F++ +
Sbjct: 569 NVI-VPYKTIEGTARGGGEDFEDTC-GELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 38.1 bits (87), Expect = 0.28
Identities = 45/166 (27%), Positives = 70/166 (42%), Gaps = 21/166 (12%)
Query: 944 QGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLNGTGGAK----------------- 986
+GTVVF + K I + + D+I EE E F V L N ++
Sbjct: 461 EGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLAC 520
Query: 987 VGNRTTATLRIRRNDDP-IYFAEPRVVRVQEG-ETANFTVLRNGSVDVTCMVQYATKDGK 1044
+G+ +TAT+ I +D I+ E V V E VLR +V Y T +G
Sbjct: 521 LGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGT 580
Query: 1045 ATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPETDEPFYI 1090
A DF + L F+ ++IS+ V +D E ++ F++
Sbjct: 581 ARGGGEDF--EDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFL 624
Score = 36.6 bits (83), Expect = 0.81
Identities = 46/190 (24%), Positives = 77/190 (40%), Gaps = 20/190 (10%)
Query: 673 VYIPLHRDGTDGQATVYWSLKPSGFNSKAVTPDDIGPFNGSVLFLSGQSDTTINITIKGD 732
V + + R G D TV+ + + A + D G+V+F G + I + I D
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGS--DYEFTEGTVVFKPGDTQKEIRVGIIDD 482
Query: 733 DIPEMNETVTLSLDRVNVENQVLKSGY--------------TSRDLIILENDDPGGVFEF 778
DI E +E + L V V ++ + G S + + +DD G+F F
Sbjct: 483 DIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTF 542
Query: 779 -SPASRGPYVIKEGESVELHIIRSRGSLVKQFLHYRVEPRDSNEFYGNT-GVLEFKPGER 836
P + I E L +RG+++ + R E + +T G LEF+
Sbjct: 543 EEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQ--ND 600
Query: 837 EIVITLLARL 846
EIV T+ ++
Sbjct: 601 EIVKTISVKV 610
Score = 34.7 bits (78), Expect = 3.1
Identities = 42/199 (21%), Positives = 84/199 (42%), Gaps = 6/199 (3%)
Query: 3481 IDIFIWEMGQSSFRYFQSVDFAAVNRIHSFTPASGIAHILLIGQDMSALYCWNSERNQFS 3540
ID I+E ++ + +V ++ A+ ++ + +G +A + +
Sbjct: 480 IDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGI 539
Query: 3541 FVLEVPSAY---DVASVTVKSLNSSKNLIALVGAHSHIYELAYISSHSDFIPSSGELIFE 3597
F E P + + + VK L +S ++ + I A DF + GEL F+
Sbjct: 540 FTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTAR-GGGEDFEDTCGELEFQ 598
Query: 3598 PGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDSVTITILSNDDAYGIVAFA 3657
E TI+V ++DD EK ++F +++ P+ E+ ++ + L G F
Sbjct: 599 NDEIVKTISVKVIDDEEYEKNKTFFLEIGEPR-LVEMSEKKALLLNELGGFTITGKYLFG 657
Query: 3658 QNSLYKQVEEMEQDSLVTL 3676
Q ++++V E L T+
Sbjct: 658 Q-PVFRKVHAREHPILSTV 675
Score = 34.3 bits (77), Expect = 4.0
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 25/159 (15%)
Query: 417 ITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDL 476
+T++R GG N +V R + +D + G + F G I + ++DDD+
Sbjct: 427 LTIIRRGGDLTNTV--FVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 477 PEEAEAYLLQILPHTIRGGAEVSE-----------------PAELLFYIQDSDDVYGLIT 519
EE E +L+ + ++ +E SE P+ I D DD G+ T
Sbjct: 485 FEEDENFLVHL--SNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFD-DDHAGIFT 541
Query: 520 FFPMENQKIESSPGERYLSLSFTRLGGTKGDVRLLYSVL 558
F E S + + R G +G+V + Y +
Sbjct: 542 F---EEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTI 577
Score = 34.3 bits (77), Expect = 4.0
Identities = 17/52 (32%), Positives = 31/52 (59%)
Query: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEE 5344
D+E T++F G+ ++++ V I+DDD E E F V L+N + ++ E+
Sbjct: 456 DYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASED 507
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 86.7 bits (213), Expect = 7e-16
Identities = 64/224 (28%), Positives = 109/224 (48%), Gaps = 6/224 (2%)
Query: 4258 TVVASDSPYGRFAFSHEQLRVSE-AQRVNITIIRSSGDFGH-VRLWYKTMSGTAEAGLDF 4315
T V + P + F + E V +TIIR GD + V + ++T GTA AG D+
Sbjct: 398 TEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDY 457
Query: 4316 VPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQID 4375
G ++F+ G+ +K + V I+DDD E E F + ++ V++ + I E +
Sbjct: 458 EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEAN-HVS 516
Query: 4376 QPPEIGNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTAD 4435
+G+ S + I +D+A GI F+ T V E +G++ + V+R G G V
Sbjct: 517 TLACLGSPSTATVTIFDDDHA-GIFTFEEPVT--HVSESIGIMEVKVLRTSGARGNVIVP 573
Query: 4436 FISQSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESE 4479
+ + +A GG D+ + FQ+ + + I++ +IDD E E
Sbjct: 574 YKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYE 617
Score = 77.0 bits (188), Expect = 5e-13
Identities = 67/223 (30%), Positives = 103/223 (46%), Gaps = 21/223 (9%)
Query: 1734 EEDGEIRLLVIRAQG-LLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792
E G + L +IR G L V +FRT TA + DY+ GT+ F+PG+ K I + I
Sbjct: 420 ENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGI 479
Query: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQILV 1852
D+ I E +++F V L N+ +V S DG +E + A LG S V
Sbjct: 480 IDDDIFEEDENFLVHLSNV--------KVSSEASEDGILE--ANHVSTLACLGSPSTATV 529
Query: 1853 TIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPDG 1911
TI DHA G+F F VS + + + V+R G V + + I+ G
Sbjct: 530 TIFDDDHA-GIFTFEEPVTHVS-----ESIGIMEVKVLRTSGARGNVIVPYKTIEGTARG 583
Query: 1912 ---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSV 1951
D T G + F+ + I+V+++ DE+ E +K F + +
Sbjct: 584 GGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 73.9 bits (180), Expect = 5e-12
Identities = 65/223 (29%), Positives = 96/223 (43%), Gaps = 27/223 (12%)
Query: 35 FTGQTEFVVNETSTTVIRLIIERIGEPANVTAIVSLYGEDA-----GDFFDTYAAAFIPA 89
F Q + E TV II R G+ N T V ED D+ T
Sbjct: 410 FFEQGTYQCLENCGTVALTIIRRGGDLTN-TVFVDFRTEDGTANAGSDYEFTEGTVVFKP 468
Query: 90 GETNRTVYIAVCDDDLPEPDETFIFHLTLQKPSANVK---------------LGWPRTVT 134
G+T + + + + DDD+ E DE F+ HL+ K S+ LG P T T
Sbjct: 469 GDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTAT 528
Query: 135 VTILSNDNAFGIISFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNP 193
VTI +D+A GI +F P VSE G M + ++R G G V+V ++ +EG
Sbjct: 529 VTIFDDDHA-GIFTFEE-PVTHVSESIG---IMEVKVLRTSGARGNVIVPYKTIEGTARG 583
Query: 194 PDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQL 236
ED G + F ++ V+DDE E ++ F +++
Sbjct: 584 GGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 72.0 bits (175), Expect = 2e-11
Identities = 65/230 (28%), Positives = 103/230 (44%), Gaps = 40/230 (17%)
Query: 3793 ENTTTLQLQIARDKG-LLGDIAIHLRAQPNFLLHVDNQATENEDYVLQETIIIMKENIKE 3851
EN T+ L I R G L + + R + D A DY E ++ K +
Sbjct: 420 ENCGTVALTIIRRGGDLTNTVFVDFRTE-------DGTANAGSDYEFTEGTVVFKPGDTQ 472
Query: 3852 AHAEVSILPDDLPELEEGFIVTIT--------------EVNLVNSDFSTGQPSVRRPGME 3897
V I+ DD+ E +E F+V ++ E N V++ G PS
Sbjct: 473 KEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPST------ 526
Query: 3898 IAEIMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGAVNVYWKA 3957
A + I + DD GIF F E +T V + +++V V+R +G+ G V V +K
Sbjct: 527 -ATVTIFD-DDHAGIFTFE------EPVT--HVSESIGIMEVKVLRTSGARGNVIVPYKT 576
Query: 3958 SPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISL 4005
+A G EDF+ + G LEF + ++ I + +IDD E+E +TF + +
Sbjct: 577 IEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 71.6 bits (174), Expect = 2e-11
Identities = 62/232 (26%), Positives = 106/232 (45%), Gaps = 38/232 (16%)
Query: 1884 TVTLNVIRHHGTLS-PVTLHWNID---SDPDGDLAFTSGNITFEIGQTSANITVEILPDE 1939
TV L +IR G L+ V + + + ++ D FT G + F+ G T I V I+ D+
Sbjct: 424 TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
Query: 1940 DPELDKAFSVSVLSVSSGS------------------LGAHINATLTVLASDDPYGIFIF 1981
E D+ F V + +V S LG+ AT+T+ DD GIF F
Sbjct: 484 IFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIF-DDDHAGIFTF 542
Query: 1982 SEKNRPVK-VEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDY 2040
E PV V E+ + + ++R G G V+V Y T++ + G D+
Sbjct: 543 EE---PVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG-----------GEDF 588
Query: 2041 IPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSI 2092
G F ++ TI++ ++DD+E E++++ F+E+ LV + +++
Sbjct: 589 EDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKAL 640
Score = 71.2 bits (173), Expect = 3e-11
Identities = 68/242 (28%), Positives = 106/242 (43%), Gaps = 37/242 (15%)
Query: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISAS- 2553
G A AGSDYE T + + GD + V I+ DD E DE+FL VHL N+ S
Sbjct: 449 GTANAGSDYE-FTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFL-----VHLSNVKVSS 502
Query: 2554 ------------LKNQPTIGQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQ 2601
+ +G P+ +TV I + D G+F + SE
Sbjct: 503 EASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAGIFTFEEPVTHVSES--------- 552
Query: 2602 PQTLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTIL 2660
++E+ + RT G+ G V V ++ + GTA G DF L F E KT+ + ++
Sbjct: 553 -IGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVI 611
Query: 2661 DDSEPEDDESIIVSLVYTEGGSRILPSSDTVRVNILANDNVAGIVSFQTASRSVIGHEGE 2720
DD E E +++ + + G R++ S+ + +L N+ ++ Q R V E
Sbjct: 612 DDEEYEKNKTFFLEI----GEPRLVEMSE--KKALLLNELGGFTITGQPVFRKVHAREHP 665
Query: 2721 IL 2722
IL
Sbjct: 666 IL 667
Score = 66.2 bits (160), Expect = 1e-09
Identities = 75/284 (26%), Positives = 117/284 (41%), Gaps = 41/284 (14%)
Query: 1968 TVLASDDPYGIFIFSEKNRPVKVEEATQNITLSIIRLKG-LMGKVLVSYATLDDMEKPPY 2026
T + +DP F + + E + L+IIR G L V V + T D
Sbjct: 398 TEVTENDPVSKIFFEQGT--YQCLENCGTVALTIIRRGGDLTNTVFVDFRTED------- 448
Query: 2027 FPPNLARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAK 2086
A G DY G +F ++ I + I+DDD E E+ + L N K
Sbjct: 449 -----GTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSN----VK 499
Query: 2087 VQSRSIPNSPRLGPKVETIAQL-------IIIANDDAFGTLQLSAPIVRVAENHVGPIIN 2139
V S + + V T+A L + I +DD G P+ V+E+ +
Sbjct: 500 VSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVK 559
Query: 2140 VTRTGGAFADVSVKFKAVPITAI-AGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELE 2198
V RT GA +V V +K + TA GED+ ++ E K + + VI+D E
Sbjct: 560 VLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKN 619
Query: 2199 ESFLVQLMNETTGGARLGALTE--AVIIIEASDDPYGLFGFQIT 2240
++F +++ G RL ++E A+++ E L GF IT
Sbjct: 620 KTFFLEI-----GEPRLVEMSEKKALLLNE-------LGGFTIT 651
Score = 66.2 bits (160), Expect = 1e-09
Identities = 60/210 (28%), Positives = 100/210 (47%), Gaps = 23/210 (10%)
Query: 4171 GTAIISLVR-GPGILGEVTVFWRIFPPSVG---EFAETSGKLTMRDEQSAVIVVIQALND 4226
GT ++++R G + V V +R + ++ T G + + + + + ++D
Sbjct: 423 GTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDD 482
Query: 4227 DIPEEKSFYEFQLTAV------SEGGVLSE----------SSSTANITVVASDSPYGRFA 4270
DI EE + L+ V SE G+L S STA +T+ D G F
Sbjct: 483 DIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHA-GIFT 541
Query: 4271 FSHEQLRVSEAQRV-NITIIRSSGDFGHVRLWYKTMSGTAEAG-LDFVPAAGELLFEAGE 4328
F VSE+ + + ++R+SG G+V + YKT+ GTA G DF GEL F+ E
Sbjct: 542 FEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDE 601
Query: 4329 MRKSLHVEILDDDYPEGPEEFSLTITKVEL 4358
+ K++ V+++DD+ E + F L I + L
Sbjct: 602 IVKTISVKVIDDEEYEKNKTFFLEIGEPRL 631
Score = 65.9 bits (159), Expect = 1e-09
Identities = 60/200 (30%), Positives = 92/200 (46%), Gaps = 22/200 (11%)
Query: 2606 VELMIHRTGGSL-GQVAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664
V L I R GG L V V++R GTA G D+ + F G+T+K + + I+DD
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 2665 PEDDESIIVSLVYTEGGSR----------------ILPSSDTVRVNILANDNVAGIVSFQ 2708
E+DE+ +V L + S L S T V I +D+ AGI +F+
Sbjct: 485 FEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDH-AGIFTFE 543
Query: 2709 TASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKII---GQNLELNFANFSGQLFFPEGSL 2765
V G I++ V+RT RGNV V +K I + +F + G+L F +
Sbjct: 544 EPVTHVSESIG-IMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEI 602
Query: 2766 NTTLFVHLLDDNIPEEKEVY 2785
T+ V ++DD E+ + +
Sbjct: 603 VKTISVKVIDDEEYEKNKTF 622
Score = 64.7 bits (156), Expect = 3e-09
Identities = 60/228 (26%), Positives = 94/228 (41%), Gaps = 27/228 (11%)
Query: 1587 EEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLN 1646
E T++ + R G D + + + E DG D+ GT+ F P + +
Sbjct: 420 ENCGTVALTIIRRGG--DLTNTVFVDFRTE-DGTANAGSDYEFTEGTVVFKPGDTQKEIR 476
Query: 1647 IYVLDDDIPELNEYF-----RVTLVSAIPGDGKLGSTPTSGASIDPEKETTDITIKASDH 1701
+ ++DDDI E +E F V + S DG L + S + T +TI DH
Sbjct: 477 VGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDH 536
Query: 1702 PYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVS 1761
G+ F P V E G + + V+R G G V ++T+
Sbjct: 537 A-GIFTFEE-----------------PVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIE 578
Query: 1762 LTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVEL 1808
TA ED+++ G LEFQ E K I + + D+ E K+F +E+
Sbjct: 579 GTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 62.8 bits (151), Expect = 1e-08
Identities = 59/209 (28%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 1017 GETANFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFV 1076
G A + R G + T V + T+DG A A D+ E T++F+ G Q+ I + +
Sbjct: 423 GTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS-DYEFTE--GTVVFKPGDTQKEIRVGI 479
Query: 1077 NEDGIPETDEPFYIILLNSTGDTVVYQYGV-----------------ATVIIEANDDPNG 1119
+D I E DE F + L N + + G+ ATV I +DD G
Sbjct: 480 IDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAG 538
Query: 1120 IFSL-EPIDKAVEEGKTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNF 1178
IF+ EP+ E +LR G G+V V ++ + +A G++F +T G + F
Sbjct: 539 IFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEG-TARGGGEDFEDTCGELEF 597
Query: 1179 MDGEEAKPIILHAFPDKIPEFNEFYFLKL 1207
+ E K I + D+ E N+ +FL++
Sbjct: 598 QNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 62.8 bits (151), Expect = 1e-08
Identities = 57/194 (29%), Positives = 87/194 (44%), Gaps = 26/194 (13%)
Query: 2138 INVTRTGGAFAD-VSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPE 2196
+ + R GG + V V F+ TA AG DY VV G+T K + + +I+D E
Sbjct: 427 LTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFE 486
Query: 2197 LEESFLVQLMNETTGG----------------ARLGALTEAVIIIEASDDPYGLFGFQIT 2240
+E+FLV L N A LG+ + A + I DD G+F F+
Sbjct: 487 EDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAGIFTFEEP 545
Query: 2241 KLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVVSGNVTFAPG 2297
V E S+ + + ++R SG GNV V + TI G G D G + F
Sbjct: 546 VTHVSE----SIGIMEVKVLRTSGARGNVIVPY-KTIEGTARGGGEDFEDTCGELEFQND 600
Query: 2298 ETIQTLLLEVLADD 2311
E ++T+ ++V+ D+
Sbjct: 601 EIVKTISVKVIDDE 614
Score = 60.8 bits (146), Expect = 4e-08
Identities = 52/221 (23%), Positives = 93/221 (42%), Gaps = 8/221 (3%)
Query: 2962 IEWQQSRFEVNETHGSLTL-VAQRSREPLGHVSLFVYAQNLEAQVGLDYIFTPMILHFAD 3020
I ++Q ++ E G++ L + +R + V + ++ A G DY FT + F
Sbjct: 409 IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKP 468
Query: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNPSPGLE------LGKNTIALIIVLANDDGPG 3074
G+ K + + I+DDDI E DE F + L+N E L N ++ + L +
Sbjct: 469 GDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTAT 528
Query: 3075 VLSFNNSE-HFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSSNESKDL 3133
V F++ F E +V ES+ ++ + G G V V + E + +D
Sbjct: 529 VTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDF 588
Query: 3134 TPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
+ G + + K + + I D E E ++ F + P
Sbjct: 589 EDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEP 629
Score = 58.5 bits (140), Expect = 2e-07
Identities = 44/164 (26%), Positives = 75/164 (45%), Gaps = 27/164 (16%)
Query: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAE----------- 3633
SD+ + G ++F+PG+ + I V I+DD + E++E+F V L N K +E
Sbjct: 455 SDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANH 514
Query: 3634 ------IGINDSVTITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGTYGR 3687
+G + T+TI +D A GI F + + E ++ + V R G G
Sbjct: 515 VSTLACLGSPSTATVTIFDDDHA-GIFTFEEPVTHVS----ESIGIMEVKVLRTSGARGN 569
Query: 3688 I-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILAD 3726
+ TI A G D T G + F +++ TI++ ++ D
Sbjct: 570 VIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDD 613
Score = 51.2 bits (121), Expect = 3e-05
Identities = 62/257 (24%), Positives = 105/257 (40%), Gaps = 39/257 (15%)
Query: 248 SRNSIEIIIKKND--SPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYEVSISY 305
S + + + +ND S + F Q Y E + + ++R + N + D
Sbjct: 392 SMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVD-------- 443
Query: 306 AVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKD 365
T + TA+A + +F + TVVF P + ++ I+DD I E E+F + L
Sbjct: 444 -FRTEDGTANAGSDYEFTE----GTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNV 498
Query: 366 TLQGD---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDR 410
+ + A L SPS VTI +D G+ + FE V +
Sbjct: 499 KVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHA-GIFT-----FEEPVTHVSES 552
Query: 411 ISRYEEITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLT 470
I E+ V+R G GNV + + D + G L F +++ TI +
Sbjct: 553 IG-IMEVKVLRTSGARGNVIVPYKTIEGTARGG--GEDFEDTCGELEFQNDEIVKTISVK 609
Query: 471 VVDDDLPEEAEAYLLQI 487
V+DD+ E+ + + L+I
Sbjct: 610 VIDDEEYEKNKTFFLEI 626
Score = 50.1 bits (118), Expect = 7e-05
Identities = 60/255 (23%), Positives = 102/255 (40%), Gaps = 39/255 (15%)
Query: 3903 IEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSF-GAVNVYWKASPDS 3961
+ END IF T Y+ + + ++R G V V ++ +
Sbjct: 400 VTENDPVSKIFFEQGT---------YQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGT 450
Query: 3962 AGL-EDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGGGRLGDDVVV 4020
A D++ + G + F I + IIDD FE E F + L +V +D ++
Sbjct: 451 ANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGIL 510
Query: 4021 -----------------TVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRS 4063
TV I +D G+F FEE + ES+ + + V+R+
Sbjct: 511 EANHVSTLACLGSPSTATVTIFDDDHA-GIFTFEEPVTHVSESI------GIMEVKVLRT 563
Query: 4064 PGGKGTVRLEW-TIDEKAK---HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFT 4119
G +G V + + TI+ A+ + G L F E KTI + + D E+++ F
Sbjct: 564 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFF 623
Query: 4120 IQLISIDEVEISPVK 4134
+++ VE+S K
Sbjct: 624 LEIGEPRLVEMSEKK 638
Score = 48.9 bits (115), Expect = 2e-04
Identities = 57/242 (23%), Positives = 103/242 (42%), Gaps = 25/242 (10%)
Query: 4409 FEVEEDVGLIMIPVVRLHGTY-GYVTADFISQSSSASPGGVDYILHGSTVTFQHGQNLSF 4467
++ E+ G + + ++R G V DF ++ +A+ G DY TV F+ G
Sbjct: 416 YQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS-DYEFTEGTVVFKPGDTQKE 474
Query: 4468 INISIIDDNESEFEEPIEILLTG------ATGGAVLGRHLVSRIIIAKSDSPFGVIRFLN 4521
I + IIDD+ E +E + L+ A+ +L + VS + S S V F +
Sbjct: 475 IRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDD 534
Query: 4522 QSK--ISIANP-----NSTMILSLVLERTGGLLGEIQVNWETVGPNSQEALLPQNRDIAD 4574
+ P S I+ + + RT G G + V ++T+ ++ D D
Sbjct: 535 DHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG----GEDFED 590
Query: 4575 PVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAKLDSRAKDVTLTIQE 4634
L + + + V+TI + + EE E +TF +++ GE +L ++ L + E
Sbjct: 591 TCGELEF--QNDEIVKTISVKVIDDEEYEKNKTFFLEI----GEPRLVEMSEKKALLLNE 644
Query: 4635 FG 4636
G
Sbjct: 645 LG 646
Score = 47.8 bits (112), Expect = 4e-04
Identities = 42/170 (24%), Positives = 78/170 (45%), Gaps = 12/170 (7%)
Query: 2891 GFLILEEGETAAAINITILEDDVPELEEYFLVNLTYV---------GLTMAASTSFPPRL 2941
G ++ + G+T I + I++DD+ E +E FLV+L+ V G+ A S L
Sbjct: 462 GTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACL 521
Query: 2942 DSEGLTAQVIIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQN 3000
S I D D G+ +++ V+E+ G + + R+ G+V + + +
Sbjct: 522 GSPSTATVTIFD--DDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEG 579
Query: 3001 LEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
G D+ T L F + E K +++ ++DD+ E ++ F L + P
Sbjct: 580 TARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEP 629
Score = 47.0 bits (110), Expect = 6e-04
Identities = 68/256 (26%), Positives = 105/256 (41%), Gaps = 45/256 (17%)
Query: 766 ILENDDPGGVFEFSPASRGPYVIKEG-ESVELHIIRSRGSLVKQ-FLHYRVEPRDSN--- 820
+ END +F +G Y E +V L IIR G L F+ +R E +N
Sbjct: 400 VTENDPVSKIF----FEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS 455
Query: 821 EFYGNTGVLEFKPGEREIVITLLARLDGIPELDEHYWVVLS----------------SHG 864
++ G + FKPG+ + I + D I E DE++ V LS +H
Sbjct: 456 DYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHV 515
Query: 865 ERESKLGSATIVNITILKNDDPHGIIEF------VSDGLIVM------INESKGDAI--Y 910
+ LGS + +TI +DD GI F VS+ + +M + ++G+ I Y
Sbjct: 516 STLACLGSPSTATVTIF-DDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPY 574
Query: 911 SAVYDVVRNRG-NFGDVSVSWVVSPDFTQDVFPVQGTVVFGDQEFSKNITIY-SLPDEIP 968
+ R G +F D D ++ V D+E+ KN T + + +
Sbjct: 575 KTIEGTARGGGEDFEDTCGELEFQND---EIVKTISVKVIDDEEYEKNKTFFLEIGEPRL 631
Query: 969 EEMEEFTVILLNGTGG 984
EM E +LLN GG
Sbjct: 632 VEMSEKKALLLNELGG 647
Score = 45.8 bits (107), Expect = 0.001
Identities = 48/176 (27%), Positives = 78/176 (44%), Gaps = 23/176 (13%)
Query: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558
A SD G + F+ G+T K + DD+ E +E F++ L +V + SE+
Sbjct: 453 AGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 1559 ------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTRGALDYV 1606
+TA +TI D+A G+F F + ++E + V RT GA V
Sbjct: 513 NHVSTLACLGSPSTATVTIFDDDHA-GIFTFEEP-VTHVSESIGIMEVKVLRTSGARGNV 570
Query: 1607 HVFY-TISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYF 1661
V Y TI G +DF + G + F + + +++ V+DD+ E N+ F
Sbjct: 571 IVPYKTIEGTARGG----GEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTF 622
Score = 45.4 bits (106), Expect = 0.002
Identities = 42/174 (24%), Positives = 74/174 (42%), Gaps = 24/174 (13%)
Query: 2239 ITKLIVEEPEFNSVK----VNLPIIRNSGTLGNVTVQWVATINGQLATG-DLRVVSGNVT 2293
++K+ E+ + ++ V L IIR G L N T +G G D G V
Sbjct: 406 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVV 465
Query: 2294 FAPGETIQTLLLEVLADDVPEIEEVIQVQL------TDASGGGTIGLDRIANI------- 2340
F PG+T + + + ++ DD+ E +E V L ++AS G + + ++ +
Sbjct: 466 FKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPS 525
Query: 2341 ---IIPANDDPYGTVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRLLLFYST 2391
+ +DD G F + V V E + + V R+ G G +++ Y T
Sbjct: 526 TATVTIFDDDHAGIFTFEEPVTHVSESI---GIMEVKVLRTSGARGNVIVPYKT 576
Score = 43.9 bits (102), Expect = 0.005
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 1/80 (1%)
Query: 166 SMPLTLIREKGTY-GMVMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDE 224
++ LT+IR G V V F E G D +G + F PG + ++DD+
Sbjct: 424 TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
Query: 225 VPENDEIFLIQLKSVEGGAE 244
+ E DE FL+ L +V+ +E
Sbjct: 484 IFEEDENFLVHLSNVKVSSE 503
Score = 42.7 bits (99), Expect = 0.011
Identities = 53/207 (25%), Positives = 82/207 (39%), Gaps = 30/207 (14%)
Query: 5131 AGMDISFPETTVAVAVDTTLIPVETESTTYLSTSKTTTILQPTNVVAIVTEATGVSAIPE 5190
AG D F E TV T + + L + V + +EA+ +
Sbjct: 453 AGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 5191 KLVTLHGTPAVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTG 5249
V+ T A P ATVT H G F+ + ++ E + EV + RT
Sbjct: 513 NHVS---TLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESI-----GIMEVKVLRTS 564
Query: 5250 GFTGNVSITVKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERE 5309
G GNV + KT +E A RG EDFE+ L F + E
Sbjct: 565 GARGNVIVPYKT-------IEGTA---RG-----------GGEDFEDTCGELEFQNDEIV 603
Query: 5310 RKVSVQILDDDEPEGQEFFYVFLTNPQ 5336
+ +SV+++DD+E E + F++ + P+
Sbjct: 604 KTISVKVIDDEEYEKNKTFFLEIGEPR 630
Score = 38.9 bits (89), Expect = 0.16
Identities = 51/239 (21%), Positives = 103/239 (43%), Gaps = 34/239 (14%)
Query: 4020 VTVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGG-KGTVRLEWTIDE 4078
V + +ND +F FE+ T E+ + V LT++R G TV +++ ++
Sbjct: 396 VNTEVTENDPVSKIF-FEQGTYQCLENCGT------VALTIIRRGGDLTNTVFVDFRTED 448
Query: 4079 ---KAKHNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKG 4135
A + GT+ F ++QK I + + D + EED F L+ + V++S
Sbjct: 449 GTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENF---LVHLSNVKVSSEAS 505
Query: 4136 SASIIIRGDKRASGEVGIAPSSRHILI-----------GEPSAKYN---GTAIISLVRGP 4181
I+ +G +PS+ + I EP + G + ++R
Sbjct: 506 EDGILEANHVSTLACLG-SPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS 564
Query: 4182 GILGEVTVFWRIFPPSV----GEFAETSGKLTMRDEQSAVIVVIQALNDDIPEE-KSFY 4235
G G V V ++ + +F +T G+L ++++ + ++ ++D+ E+ K+F+
Sbjct: 565 GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFF 623
Score = 38.1 bits (87), Expect = 0.28
Identities = 59/240 (24%), Positives = 102/240 (42%), Gaps = 37/240 (15%)
Query: 4879 VSEKAANSQVGFESTAFQLMNITAGTSHVMISRRG--TYGALSVAWTT--GYAPGLEIPE 4934
V+E S++ FE +Q + GT + I RRG + V + T G A E
Sbjct: 400 VTENDPVSKIFFEQGTYQCLE-NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYE 458
Query: 4935 FIVVGNMTPTLGSLSFSHGEQRKGVFLWTFPSPGWPEA--FVLHLSGVQSSAPG------ 4986
F T G++ F G+ +K + + + E F++HLS V+ S+
Sbjct: 459 F--------TEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGIL 510
Query: 4987 -----------GAQLRSGFIVAEIEPMGVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHS 5035
G+ + + + + G+F F + VSE ++ + V R G
Sbjct: 511 EANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTH--VSESIGIMEVKVLRTSGARG 568
Query: 5036 DLIKVSYQTTAGSAKPL-EDFEPVQNGELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5094
++I V Y+T G+A+ EDFE GEL FQ + + +I+D+ E + F++ +
Sbjct: 569 NVI-VPYKTIEGTARGGGEDFEDTC-GELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEI 626
Score = 38.1 bits (87), Expect = 0.28
Identities = 45/166 (27%), Positives = 70/166 (42%), Gaps = 21/166 (12%)
Query: 944 QGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLNGTGGAK----------------- 986
+GTVVF + K I + + D+I EE E F V L N ++
Sbjct: 461 EGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLAC 520
Query: 987 VGNRTTATLRIRRNDDP-IYFAEPRVVRVQEG-ETANFTVLRNGSVDVTCMVQYATKDGK 1044
+G+ +TAT+ I +D I+ E V V E VLR +V Y T +G
Sbjct: 521 LGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGT 580
Query: 1045 ATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPETDEPFYI 1090
A DF + L F+ ++IS+ V +D E ++ F++
Sbjct: 581 ARGGGEDF--EDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFL 624
Score = 36.6 bits (83), Expect = 0.81
Identities = 46/190 (24%), Positives = 77/190 (40%), Gaps = 20/190 (10%)
Query: 673 VYIPLHRDGTDGQATVYWSLKPSGFNSKAVTPDDIGPFNGSVLFLSGQSDTTINITIKGD 732
V + + R G D TV+ + + A + D G+V+F G + I + I D
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGS--DYEFTEGTVVFKPGDTQKEIRVGIIDD 482
Query: 733 DIPEMNETVTLSLDRVNVENQVLKSGY--------------TSRDLIILENDDPGGVFEF 778
DI E +E + L V V ++ + G S + + +DD G+F F
Sbjct: 483 DIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTF 542
Query: 779 -SPASRGPYVIKEGESVELHIIRSRGSLVKQFLHYRVEPRDSNEFYGNT-GVLEFKPGER 836
P + I E L +RG+++ + R E + +T G LEF+
Sbjct: 543 EEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQ--ND 600
Query: 837 EIVITLLARL 846
EIV T+ ++
Sbjct: 601 EIVKTISVKV 610
Score = 34.3 bits (77), Expect = 4.0
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 25/159 (15%)
Query: 417 ITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDL 476
+T++R GG N +V R + +D + G + F G I + ++DDD+
Sbjct: 427 LTIIRRGGDLTNTV--FVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 477 PEEAEAYLLQILPHTIRGGAEVSE-----------------PAELLFYIQDSDDVYGLIT 519
EE E +L+ + ++ +E SE P+ I D DD G+ T
Sbjct: 485 FEEDENFLVHL--SNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFD-DDHAGIFT 541
Query: 520 FFPMENQKIESSPGERYLSLSFTRLGGTKGDVRLLYSVL 558
F E S + + R G +G+V + Y +
Sbjct: 542 F---EEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTI 577
Score = 34.3 bits (77), Expect = 4.0
Identities = 17/52 (32%), Positives = 31/52 (59%)
Query: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEE 5344
D+E T++F G+ ++++ V I+DDD E E F V L+N + ++ E+
Sbjct: 456 DYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASED 507
Score = 34.3 bits (77), Expect = 4.0
Identities = 33/152 (21%), Positives = 66/152 (43%), Gaps = 4/152 (2%)
Query: 3481 IDIFIWEMGQSSFRYFQSVDFAAVNRIHSFTPASGIAHILLIGQDMSALYCWNSERNQFS 3540
ID I+E ++ + +V ++ A+ ++ + +G +A + +
Sbjct: 480 IDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGI 539
Query: 3541 FVLEVPSAY---DVASVTVKSLNSSKNLIALVGAHSHIYELAYISSHSDFIPSSGELIFE 3597
F E P + + + VK L +S ++ + I A DF + GEL F+
Sbjct: 540 FTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTAR-GGGEDFEDTCGELEFQ 598
Query: 3598 PGEREATIAVNILDDTVPEKEESFKVQLKNPK 3629
E TI+V ++DD EK ++F +++ P+
Sbjct: 599 NDEIVKTISVKVIDDEEYEKNKTFFLEIGEPR 630
>gi|148806925 EGF, latrophilin and seven transmembrane domain
containing 1 [Homo sapiens]
Length = 690
Score = 86.7 bits (213), Expect = 7e-16
Identities = 75/327 (22%), Positives = 144/327 (44%), Gaps = 44/327 (13%)
Query: 5854 SLCLLWNQAA----ASWLSDSQFCKVVEETADYVECACSHMSVYAVYARTD---NLSSYN 5906
SLC WN + SW S+ C++ + C C+H++ +A+ + + YN
Sbjct: 368 SLCAFWNYSPDTMNGSWSSEG--CELTYSNETHTSCRCNHLTHFAILMSSGPSIGIKDYN 425
Query: 5907 EAF-FTSGFICISGLCLAVLSHIFCARYSMFAAKLLTH--MMAASLGTQILFLASAYASP 5963
T I IS +CLA+ F + + + H + + +++FL +
Sbjct: 426 ILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNT 485
Query: 5964 QLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLV---MNDEHTERRYLLFFLLSWGL 6020
+ CS +A + HY +L F+WM I+ ++ + ++V N + + +F LS
Sbjct: 486 N--KLFCSIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLS--- 540
Query: 6021 PAFVVILLIVILKGIYHQSMSQIYGLIHGDLCFIPN----VYAALFTAALVPLTCL---- 6072
PA VV G + YG +C++ +++ + A L+ L L
Sbjct: 541 PAVVV--------GFSAALGYRYYGTTK--VCWLSTENNFIWSFIGPACLIILVNLLAFG 590
Query: 6073 VVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWLWGGLHMAYRHFW 6132
V+++ VF H +KP+ ++++ A L L L+ TW++G LH+ +
Sbjct: 591 VIIYKVFRHTAGLKPEVSCFENIRSCARGA------LALLFLLGTTWIFGVLHVVHASVV 644
Query: 6133 MLVLFVIFNSLQGLYVFMVYFILHNQM 6159
LF + N+ QG+++F+ +L ++
Sbjct: 645 TAYLFTVSNAFQGMFIFLFLCVLSRKI 671
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 84.3 bits (207), Expect = 3e-15
Identities = 66/233 (28%), Positives = 110/233 (47%), Gaps = 6/233 (2%)
Query: 4258 TVVASDSPYGRFAFSHEQLRVSE-AQRVNITIIRSSGDFGH-VRLWYKTMSGTAEAGLDF 4315
T V + P + F + E V +TIIR GD + V + ++T GTA AG D+
Sbjct: 398 TEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDY 457
Query: 4316 VPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQID 4375
G ++F+ G+ +K + V I+DDD E E F + ++ V++ + I E +
Sbjct: 458 EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEAN-HVS 516
Query: 4376 QPPEIGNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTAD 4435
+G+ S + I +D+A GI F+ T V E +G++ + V+R G G V
Sbjct: 517 TLACLGSPSTATVTIFDDDHA-GIFTFEEPVT--HVSESIGIMEVKVLRTSGARGNVIVP 573
Query: 4436 FISQSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4488
+ + +A GG D+ + FQ+ + + I I I D E E E ++L
Sbjct: 574 YKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 72.0 bits (175), Expect = 2e-11
Identities = 67/221 (30%), Positives = 100/221 (45%), Gaps = 21/221 (9%)
Query: 1734 EEDGEIRLLVIRAQG-LLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792
E G + L +IR G L V +FRT TA + DY+ GT+ F+PG+ K I + I
Sbjct: 420 ENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGI 479
Query: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQILV 1852
D+ I E +++F V L N+ +V S DG +E + A LG S V
Sbjct: 480 IDDDIFEEDENFLVHLSNV--------KVSSEASEDGILE--ANHVSTLACLGSPSTATV 529
Query: 1853 TIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPDG 1911
TI DHA G+F F VS + + + V+R G V + + I+ G
Sbjct: 530 TIFDDDHA-GIFTFEEPVTHVS-----ESIGIMEVKVLRTSGARGNVIVPYKTIEGTARG 583
Query: 1912 ---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSV 1949
D T G + F+ + IT+ I E+ E + +FS+
Sbjct: 584 GGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSL 624
Score = 69.3 bits (168), Expect = 1e-10
Identities = 70/261 (26%), Positives = 105/261 (40%), Gaps = 34/261 (13%)
Query: 35 FTGQTEFVVNETSTTVIRLIIERIGEPANVTAIVSLYGEDA-----GDFFDTYAAAFIPA 89
F Q + E TV II R G+ N T V ED D+ T
Sbjct: 410 FFEQGTYQCLENCGTVALTIIRRGGDLTN-TVFVDFRTEDGTANAGSDYEFTEGTVVFKP 468
Query: 90 GETNRTVYIAVCDDDLPEPDETFIFHLTLQKPSANVK---------------LGWPRTVT 134
G+T + + + + DDD+ E DE F+ HL+ K S+ LG P T T
Sbjct: 469 GDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTAT 528
Query: 135 VTILSNDNAFGIISFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNP 193
VTI +D+A GI +F P VSE G M + ++R G G V+V ++ +EG
Sbjct: 529 VTIFDDDHA-GIFTFEE-PVTHVSESIG---IMEVKVLRTSGARGNVIVPYKTIEGTARG 583
Query: 194 PDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQL-------KSVEGGAEIN 246
ED G + F I + + D E E + F + L + ++GG I
Sbjct: 584 GGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTIT 643
Query: 247 TSRNSIEIIIKKNDSPVRFLQ 267
+ + + K + R +
Sbjct: 644 DEYDDKQPLTSKEEEERRIAE 664
Score = 66.2 bits (160), Expect = 1e-09
Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 40/230 (17%)
Query: 3793 ENTTTLQLQIARDKG-LLGDIAIHLRAQPNFLLHVDNQATENEDYVLQETIIIMKENIKE 3851
EN T+ L I R G L + + R + D A DY E ++ K +
Sbjct: 420 ENCGTVALTIIRRGGDLTNTVFVDFRTE-------DGTANAGSDYEFTEGTVVFKPGDTQ 472
Query: 3852 AHAEVSILPDDLPELEEGFIV--------------TITEVNLVNSDFSTGQPSVRRPGME 3897
V I+ DD+ E +E F+V I E N V++ G PS
Sbjct: 473 KEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPST------ 526
Query: 3898 IAEIMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGAVNVYWKA 3957
A + I + DD GIF F E +T V + +++V V+R +G+ G V V +K
Sbjct: 527 -ATVTIFD-DDHAGIFTFE------EPVT--HVSESIGIMEVKVLRTSGARGNVIVPYKT 576
Query: 3958 SPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISL 4005
+A G EDF+ + G LEF + ++ +I I I D E+E +F++ L
Sbjct: 577 IEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 64.3 bits (155), Expect = 4e-09
Identities = 63/228 (27%), Positives = 92/228 (40%), Gaps = 27/228 (11%)
Query: 1587 EEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLN 1646
E T++ + R G D + + + E DG D+ GT+ F P + +
Sbjct: 420 ENCGTVALTIIRRGG--DLTNTVFVDFRTE-DGTANAGSDYEFTEGTVVFKPGDTQKEIR 476
Query: 1647 IYVLDDDIPELNEYF-----RVTLVSAIPGDGKLGSTPTSGASIDPEKETTDITIKASDH 1701
+ ++DDDI E +E F V + S DG L + S + T +TI DH
Sbjct: 477 VGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDH 536
Query: 1702 PYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVS 1761
G+ F P V E G + + V+R G G V ++T+
Sbjct: 537 A-GIFTFEE-----------------PVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIE 578
Query: 1762 LTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVEL 1808
TA ED+++ G LEFQ E K I I I D E E SF + L
Sbjct: 579 GTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 62.8 bits (151), Expect = 1e-08
Identities = 61/199 (30%), Positives = 85/199 (42%), Gaps = 33/199 (16%)
Query: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISAS- 2553
G A AGSDYE T + + GD + V I+ DD E DE+FL VHL N+ S
Sbjct: 449 GTANAGSDYE-FTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFL-----VHLSNVKVSS 502
Query: 2554 ------------LKNQPTIGQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQ 2601
+ +G P+ +TV I + D G+F + SE
Sbjct: 503 EASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAGIFTFEEPVTHVSES--------- 552
Query: 2602 PQTLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTIL 2660
++E+ + RT G+ G V V ++ + GTA G DF L F E K + + I
Sbjct: 553 -IGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIF 611
Query: 2661 DDSEPEDDESIIVSLVYTE 2679
D E E + S SLV E
Sbjct: 612 DREEYEKECSF--SLVLEE 628
Score = 62.4 bits (150), Expect = 1e-08
Identities = 63/223 (28%), Positives = 102/223 (45%), Gaps = 25/223 (11%)
Query: 4171 GTAIISLVR-GPGILGEVTVFWRIFPPSVG---EFAETSGKLTMRDEQSAVIVVIQALND 4226
GT ++++R G + V V +R + ++ T G + + + + + ++D
Sbjct: 423 GTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDD 482
Query: 4227 DIPEEKSFYEFQLTAV------SEGGVLSE----------SSSTANITVVASDSPYGRFA 4270
DI EE + L+ V SE G+L S STA +T+ D G F
Sbjct: 483 DIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHA-GIFT 541
Query: 4271 FSHEQLRVSEAQRV-NITIIRSSGDFGHVRLWYKTMSGTAEAG-LDFVPAAGELLFEAGE 4328
F VSE+ + + ++R+SG G+V + YKT+ GTA G DF GEL F+ E
Sbjct: 542 FEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDE 601
Query: 4329 MRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGY--DFTIQE 4369
+ K + + I D + E FSL + + + RG FTI +
Sbjct: 602 IVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITD 644
Score = 60.8 bits (146), Expect = 4e-08
Identities = 58/204 (28%), Positives = 92/204 (45%), Gaps = 22/204 (10%)
Query: 2606 VELMIHRTGGSL-GQVAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664
V L I R GG L V V++R GTA G D+ + F G+T+K + + I+DD
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 2665 PEDDESIIVSLVYTEGGSR----------------ILPSSDTVRVNILANDNVAGIVSFQ 2708
E+DE+ +V L + S L S T V I +D+ AGI +F+
Sbjct: 485 FEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDH-AGIFTFE 543
Query: 2709 TASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKII---GQNLELNFANFSGQLFFPEGSL 2765
V G I++ V+RT RGNV V +K I + +F + G+L F +
Sbjct: 544 EPVTHVSESIG-IMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEI 602
Query: 2766 NTTLFVHLLDDNIPEEKEVYQVIL 2789
+ + + D E++ + ++L
Sbjct: 603 VKIITIRIFDREEYEKECSFSLVL 626
Score = 60.5 bits (145), Expect = 5e-08
Identities = 65/247 (26%), Positives = 98/247 (39%), Gaps = 27/247 (10%)
Query: 1968 TVLASDDPYGIFIFSEKNRPVKVEEATQNITLSIIRLKG-LMGKVLVSYATLDDMEKPPY 2026
T + +DP F + + E + L+IIR G L V V + T D
Sbjct: 398 TEVTENDPVSKIFFEQGT--YQCLENCGTVALTIIRRGGDLTNTVFVDFRTED------- 448
Query: 2027 FPPNLARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAK 2086
A G DY G +F ++ I + I+DDD E E+ + L N K
Sbjct: 449 -----GTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSN----VK 499
Query: 2087 VQSRSIPNSPRLGPKVETIAQL-------IIIANDDAFGTLQLSAPIVRVAENHVGPIIN 2139
V S + + V T+A L + I +DD G P+ V+E+ +
Sbjct: 500 VSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVK 559
Query: 2140 VTRTGGAFADVSVKFKAVPITAI-AGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELE 2198
V RT GA +V V +K + TA GED+ ++ E K + I + + E E
Sbjct: 560 VLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKE 619
Query: 2199 ESFLVQL 2205
SF + L
Sbjct: 620 CSFSLVL 626
Score = 57.4 bits (137), Expect = 4e-07
Identities = 60/218 (27%), Positives = 92/218 (42%), Gaps = 38/218 (17%)
Query: 1884 TVTLNVIRHHGTLS-PVTLHWNID---SDPDGDLAFTSGNITFEIGQTSANITVEILPDE 1939
TV L +IR G L+ V + + + ++ D FT G + F+ G T I V I+ D+
Sbjct: 424 TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
Query: 1940 DPELDKAFSVSVLSVSSGS------------------LGAHINATLTVLASDDPYGIFIF 1981
E D+ F V + +V S LG+ AT+T+ DD GIF F
Sbjct: 484 IFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIF-DDDHAGIFTF 542
Query: 1982 SEKNRPV-KVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDY 2040
E PV V E+ + + ++R G G V+V Y T++ + G D+
Sbjct: 543 EE---PVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTAR-----------GGGEDF 588
Query: 2041 IPASGFALFGANQSEATIAISILDDDEPERSESVFIEL 2078
G F ++ I I I D +E E+ S + L
Sbjct: 589 EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 57.4 bits (137), Expect = 4e-07
Identities = 54/190 (28%), Positives = 82/190 (43%), Gaps = 26/190 (13%)
Query: 2138 INVTRTGGAFAD-VSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPE 2196
+ + R GG + V V F+ TA AG DY VV G+T K + + +I+D E
Sbjct: 427 LTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFE 486
Query: 2197 LEESFLVQLMNETTGG----------------ARLGALTEAVIIIEASDDPYGLFGFQIT 2240
+E+FLV L N A LG+ + A + I DD G+F F+
Sbjct: 487 EDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAGIFTFEEP 545
Query: 2241 KLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVVSGNVTFAPG 2297
V E S+ + + ++R SG GNV V + TI G G D G + F
Sbjct: 546 VTHVSE----SIGIMEVKVLRTSGARGNVIVPY-KTIEGTARGGGEDFEDTCGELEFQND 600
Query: 2298 ETIQTLLLEV 2307
E ++ + + +
Sbjct: 601 EIVKIITIRI 610
Score = 56.2 bits (134), Expect = 1e-06
Identities = 55/194 (28%), Positives = 86/194 (44%), Gaps = 23/194 (11%)
Query: 1017 GETANFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFV 1076
G A + R G + T V + T+DG A A D+ E T++F+ G Q+ I + +
Sbjct: 423 GTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS-DYEFTE--GTVVFKPGDTQKEIRVGI 479
Query: 1077 NEDGIPETDEPFYIILLNSTGDTVVYQYGV-----------------ATVIIEANDDPNG 1119
+D I E DE F + L N + + G+ ATV I +DD G
Sbjct: 480 IDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAG 538
Query: 1120 IFSL-EPIDKAVEEGKTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNF 1178
IF+ EP+ E +LR G G+V V ++ + +A G++F +T G + F
Sbjct: 539 IFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEG-TARGGGEDFEDTCGELEF 597
Query: 1179 MDGEEAKPIILHAF 1192
+ E K I + F
Sbjct: 598 QNDEIVKIITIRIF 611
Score = 56.2 bits (134), Expect = 1e-06
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 27/161 (16%)
Query: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAE----------- 3633
SD+ + G ++F+PG+ + I V I+DD + E++E+F V L N K +E
Sbjct: 455 SDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANH 514
Query: 3634 ------IGINDSVTITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGTYGR 3687
+G + T+TI +D A GI F + + E ++ + V R G G
Sbjct: 515 VSTLACLGSPSTATVTIFDDDHA-GIFTFEEPVTHVS----ESIGIMEVKVLRTSGARGN 569
Query: 3688 I-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTI 3723
+ TI A G D T G + F +++ IT+ I
Sbjct: 570 VIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRI 610
Score = 54.3 bits (129), Expect = 4e-06
Identities = 52/221 (23%), Positives = 90/221 (40%), Gaps = 8/221 (3%)
Query: 2962 IEWQQSRFEVNETHGSLTL-VAQRSREPLGHVSLFVYAQNLEAQVGLDYIFTPMILHFAD 3020
I ++Q ++ E G++ L + +R + V + ++ A G DY FT + F
Sbjct: 409 IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKP 468
Query: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNPSPGLE------LGKNTIALIIVLANDDGPG 3074
G+ K + + I+DDDI E DE F + L+N E L N ++ + L +
Sbjct: 469 GDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTAT 528
Query: 3075 VLSFNNSE-HFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSSNESKDL 3133
V F++ F E +V ES+ ++ + G G V V + E + +D
Sbjct: 529 VTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDF 588
Query: 3134 TPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
+ G + + K + I E E + F L P
Sbjct: 589 EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEP 629
Score = 46.6 bits (109), Expect = 8e-04
Identities = 44/170 (25%), Positives = 75/170 (44%), Gaps = 12/170 (7%)
Query: 2891 GFLILEEGETAAAINITILEDDVPELEEYFLVNLTYV---------GLTMAASTSFPPRL 2941
G ++ + G+T I + I++DD+ E +E FLV+L+ V G+ A S L
Sbjct: 462 GTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACL 521
Query: 2942 DSEGLTAQVIIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQN 3000
S I D D G+ +++ V+E+ G + + R+ G+V + + +
Sbjct: 522 GSPSTATVTIFD--DDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEG 579
Query: 3001 LEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
G D+ T L F + E K + I I D + E + F L+L P
Sbjct: 580 TARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEP 629
Score = 45.4 bits (106), Expect = 0.002
Identities = 42/174 (24%), Positives = 74/174 (42%), Gaps = 24/174 (13%)
Query: 2239 ITKLIVEEPEFNSVK----VNLPIIRNSGTLGNVTVQWVATINGQLATG-DLRVVSGNVT 2293
++K+ E+ + ++ V L IIR G L N T +G G D G V
Sbjct: 406 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVV 465
Query: 2294 FAPGETIQTLLLEVLADDVPEIEEVIQVQL------TDASGGGTIGLDRIANI------- 2340
F PG+T + + + ++ DD+ E +E V L ++AS G + + ++ +
Sbjct: 466 FKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPS 525
Query: 2341 ---IIPANDDPYGTVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRLLLFYST 2391
+ +DD G F + V V E + + V R+ G G +++ Y T
Sbjct: 526 TATVTIFDDDHAGIFTFEEPVTHVSESI---GIMEVKVLRTSGARGNVIVPYKT 576
Score = 42.4 bits (98), Expect = 0.015
Identities = 55/243 (22%), Positives = 93/243 (38%), Gaps = 39/243 (16%)
Query: 3903 IEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSF-GAVNVYWKASPDS 3961
+ END IF T Y+ + + ++R G V V ++ +
Sbjct: 400 VTENDPVSKIFFEQGT---------YQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGT 450
Query: 3962 AGL-EDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGGGRLGDDVVV 4020
A D++ + G + F I + IIDD FE E F + L +V +D ++
Sbjct: 451 ANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGIL 510
Query: 4021 -----------------TVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRS 4063
TV I +D G+F FEE + ES+ + + V+R+
Sbjct: 511 EANHVSTLACLGSPSTATVTIFDDDHA-GIFTFEEPVTHVSESI------GIMEVKVLRT 563
Query: 4064 PGGKGTVRLEW-TIDEKAK---HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFT 4119
G +G V + + TI+ A+ + G L F E K I + E++ F+
Sbjct: 564 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFS 623
Query: 4120 IQL 4122
+ L
Sbjct: 624 LVL 626
Score = 42.0 bits (97), Expect = 0.019
Identities = 62/266 (23%), Positives = 104/266 (39%), Gaps = 40/266 (15%)
Query: 248 SRNSIEIIIKKND--SPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYEVSISY 305
S + + + +ND S + F Q Y E + + ++R + N + D
Sbjct: 392 SMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVD-------- 443
Query: 306 AVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKD 365
T + TA+A + +F + TVVF P + ++ I+DD I E E+F + L
Sbjct: 444 -FRTEDGTANAGSDYEFTE----GTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNV 498
Query: 366 TLQGD---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDR 410
+ + A L SPS VTI +D G+ + FE V +
Sbjct: 499 KVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHA-GIFT-----FEEPVTHVSES 552
Query: 411 ISRYEEITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLT 470
I E+ V+R G GNV + + D + G L F +++ I +
Sbjct: 553 IG-IMEVKVLRTSGARGNVIVPYKTIEGTARGG--GEDFEDTCGELEFQNDEIVKIITIR 609
Query: 471 VVD-DDLPEEAEAYLLQILPHTIRGG 495
+ D ++ +E L+ P IR G
Sbjct: 610 IFDREEYEKECSFSLVLEEPKWIRRG 635
Score = 42.0 bits (97), Expect = 0.019
Identities = 64/238 (26%), Positives = 98/238 (41%), Gaps = 36/238 (15%)
Query: 766 ILENDDPGGVFEFSPASRGPYVIKEG-ESVELHIIRSRGSLVKQ-FLHYRVEPRDSN--- 820
+ END +F +G Y E +V L IIR G L F+ +R E +N
Sbjct: 400 VTENDPVSKIF----FEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS 455
Query: 821 EFYGNTGVLEFKPGEREIVITLLARLDGIPELDEHYWVVLS----------------SHG 864
++ G + FKPG+ + I + D I E DE++ V LS +H
Sbjct: 456 DYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHV 515
Query: 865 ERESKLGSATIVNITILKNDDPHGIIEFVSDGLIVMINESKGDAIYSAVYDVVRNRGNFG 924
+ LGS + +TI +DD GI F + + ++ES G V+R G G
Sbjct: 516 STLACLGSPSTATVTIF-DDDHAGIFTF--EEPVTHVSESIG----IMEVKVLRTSGARG 568
Query: 925 DVSVSWVVSPDFT----QDVFPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVIL 978
+V V + +D G + F + E K ITI E E+ F+++L
Sbjct: 569 NVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 40.4 bits (93), Expect = 0.056
Identities = 56/225 (24%), Positives = 85/225 (37%), Gaps = 37/225 (16%)
Query: 5131 AGMDISFPETTVAVAVDTTLIPVETESTTYLSTSKTTTILQPTNVVAIVTEATGVSAIPE 5190
AG D F E TV T + + L + V + +EA+ +
Sbjct: 453 AGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 5191 KLVTLHGTPAVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTG 5249
V+ T A P ATVT H G F+ + ++ E + EV + RT
Sbjct: 513 NHVS---TLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESI-----GIMEVKVLRTS 564
Query: 5250 GFTGNVSITVKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERE 5309
G GNV + P++ I G T EDFE+ L F + E
Sbjct: 565 GARGNVIV-----------------PYKTIEG----TARGGGEDFEDTCGELEFQNDEIV 603
Query: 5310 RKVSVQILDDDEPEGQEFFYVFLTNP-------QGGAQIVEEKDD 5347
+ ++++I D +E E + F + L P +GG I +E DD
Sbjct: 604 KIITIRIFDREEYEKECSFSLVLEEPKWIRRGMKGGFTITDEYDD 648
Score = 40.0 bits (92), Expect = 0.073
Identities = 47/180 (26%), Positives = 76/180 (42%), Gaps = 23/180 (12%)
Query: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558
A SD G + F+ G+T K + DD+ E +E F++ L +V + SE+
Sbjct: 453 AGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 1559 ------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTRGALDYV 1606
+TA +TI D+A G+F F + ++E + V RT GA V
Sbjct: 513 NHVSTLACLGSPSTATVTIFDDDHA-GIFTFEEP-VTHVSESIGIMEVKVLRTSGARGNV 570
Query: 1607 HVFY-TISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTL 1665
V Y TI G +DF + G + F + +++ I + D + E F + L
Sbjct: 571 IVPYKTIEGTARGG----GEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 38.5 bits (88), Expect = 0.21
Identities = 45/186 (24%), Positives = 75/186 (40%), Gaps = 18/186 (9%)
Query: 673 VYIPLHRDGTDGQATVYWSLKPSGFNSKAVTPDDIGPFNGSVLFLSGQSDTTINITIKGD 732
V + + R G D TV+ + + A + D G+V+F G + I + I D
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGS--DYEFTEGTVVFKPGDTQKEIRVGIIDD 482
Query: 733 DIPEMNETVTLSLDRVNVENQVLKSGY--------------TSRDLIILENDDPGGVFEF 778
DI E +E + L V V ++ + G S + + +DD G+F F
Sbjct: 483 DIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTF 542
Query: 779 -SPASRGPYVIKEGESVELHIIRSRGSLVKQFLHYRVEPRDSNEFYGNT-GVLEFKPGER 836
P + I E L +RG+++ + R E + +T G LEF+ E
Sbjct: 543 EEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEI 602
Query: 837 EIVITL 842
+IT+
Sbjct: 603 VKIITI 608
Score = 37.7 bits (86), Expect = 0.36
Identities = 52/238 (21%), Positives = 101/238 (42%), Gaps = 34/238 (14%)
Query: 4020 VTVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGG-KGTVRLEWTIDE 4078
V + +ND +F FE+ T E+ + V LT++R G TV +++ ++
Sbjct: 396 VNTEVTENDPVSKIF-FEQGTYQCLENCGT------VALTIIRRGGDLTNTVFVDFRTED 448
Query: 4079 ---KAKHNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKG 4135
A + GT+ F ++QK I + + D + EED F L+ + V++S
Sbjct: 449 GTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENF---LVHLSNVKVSSEAS 505
Query: 4136 SASIIIRGDKRASGEVGIAPSSRHILI-----------GEPSAKYN---GTAIISLVRGP 4181
I+ +G +PS+ + I EP + G + ++R
Sbjct: 506 EDGILEANHVSTLACLG-SPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS 564
Query: 4182 GILGEVTVFWRIFPPSV----GEFAETSGKLTMRDEQSAVIVVIQALN-DDIPEEKSF 4234
G G V V ++ + +F +T G+L ++++ I+ I+ + ++ +E SF
Sbjct: 565 GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSF 622
Score = 35.4 bits (80), Expect = 1.8
Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 19/128 (14%)
Query: 944 QGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLNGTGGAK----------------- 986
+GTVVF + K I + + D+I EE E F V L N ++
Sbjct: 461 EGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLAC 520
Query: 987 VGNRTTATLRIRRNDDP-IYFAEPRVVRVQEG-ETANFTVLRNGSVDVTCMVQYATKDGK 1044
+G+ +TAT+ I +D I+ E V V E VLR +V Y T +G
Sbjct: 521 LGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGT 580
Query: 1045 ATARERDF 1052
A DF
Sbjct: 581 ARGGGEDF 588
Score = 34.3 bits (77), Expect = 4.0
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 25/159 (15%)
Query: 417 ITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDL 476
+T++R GG N +V R + +D + G + F G I + ++DDD+
Sbjct: 427 LTIIRRGGDLTNTV--FVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 477 PEEAEAYLLQILPHTIRGGAEVSE-----------------PAELLFYIQDSDDVYGLIT 519
EE E +L+ + ++ +E SE P+ I D DD G+ T
Sbjct: 485 FEEDENFLVHL--SNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFD-DDHAGIFT 541
Query: 520 FFPMENQKIESSPGERYLSLSFTRLGGTKGDVRLLYSVL 558
F E S + + R G +G+V + Y +
Sbjct: 542 F---EEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTI 577
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 84.3 bits (207), Expect = 3e-15
Identities = 66/233 (28%), Positives = 110/233 (47%), Gaps = 6/233 (2%)
Query: 4258 TVVASDSPYGRFAFSHEQLRVSE-AQRVNITIIRSSGDFGH-VRLWYKTMSGTAEAGLDF 4315
T V + P + F + E V +TIIR GD + V + ++T GTA AG D+
Sbjct: 398 TEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDY 457
Query: 4316 VPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQID 4375
G ++F+ G+ +K + V I+DDD E E F + ++ V++ + I E +
Sbjct: 458 EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEAN-HVS 516
Query: 4376 QPPEIGNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTAD 4435
+G+ S + I +D+A GI F+ T V E +G++ + V+R G G V
Sbjct: 517 TLACLGSPSTATVTIFDDDHA-GIFTFEEPVT--HVSESIGIMEVKVLRTSGARGNVIVP 573
Query: 4436 FISQSSSASPGGVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4488
+ + +A GG D+ + FQ+ + + I I I D E E E ++L
Sbjct: 574 YKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 72.0 bits (175), Expect = 2e-11
Identities = 67/221 (30%), Positives = 100/221 (45%), Gaps = 21/221 (9%)
Query: 1734 EEDGEIRLLVIRAQG-LLGRVTAEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792
E G + L +IR G L V +FRT TA + DY+ GT+ F+PG+ K I + I
Sbjct: 420 ENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGI 479
Query: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDGDMEFFLPTIHKRASLGVASQILV 1852
D+ I E +++F V L N+ +V S DG +E + A LG S V
Sbjct: 480 IDDDIFEEDENFLVHLSNV--------KVSSEASEDGILE--ANHVSTLACLGSPSTATV 529
Query: 1853 TIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPDG 1911
TI DHA G+F F VS + + + V+R G V + + I+ G
Sbjct: 530 TIFDDDHA-GIFTFEEPVTHVS-----ESIGIMEVKVLRTSGARGNVIVPYKTIEGTARG 583
Query: 1912 ---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSV 1949
D T G + F+ + IT+ I E+ E + +FS+
Sbjct: 584 GGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSL 624
Score = 68.6 bits (166), Expect = 2e-10
Identities = 65/224 (29%), Positives = 93/224 (41%), Gaps = 27/224 (12%)
Query: 35 FTGQTEFVVNETSTTVIRLIIERIGEPANVTAIVSLYGEDA-----GDFFDTYAAAFIPA 89
F Q + E TV II R G+ N T V ED D+ T
Sbjct: 410 FFEQGTYQCLENCGTVALTIIRRGGDLTN-TVFVDFRTEDGTANAGSDYEFTEGTVVFKP 468
Query: 90 GETNRTVYIAVCDDDLPEPDETFIFHLTLQKPSANVK---------------LGWPRTVT 134
G+T + + + + DDD+ E DE F+ HL+ K S+ LG P T T
Sbjct: 469 GDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTAT 528
Query: 135 VTILSNDNAFGIISFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNP 193
VTI +D+A GI +F P VSE G M + ++R G G V+V ++ +EG
Sbjct: 529 VTIFDDDHA-GIFTFEE-PVTHVSESIG---IMEVKVLRTSGARGNVIVPYKTIEGTARG 583
Query: 194 PDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPENDEIFLIQLK 237
ED G + F I + + D E E + F + L+
Sbjct: 584 GGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLE 627
Score = 66.2 bits (160), Expect = 1e-09
Identities = 66/230 (28%), Positives = 101/230 (43%), Gaps = 40/230 (17%)
Query: 3793 ENTTTLQLQIARDKG-LLGDIAIHLRAQPNFLLHVDNQATENEDYVLQETIIIMKENIKE 3851
EN T+ L I R G L + + R + D A DY E ++ K +
Sbjct: 420 ENCGTVALTIIRRGGDLTNTVFVDFRTE-------DGTANAGSDYEFTEGTVVFKPGDTQ 472
Query: 3852 AHAEVSILPDDLPELEEGFIV--------------TITEVNLVNSDFSTGQPSVRRPGME 3897
V I+ DD+ E +E F+V I E N V++ G PS
Sbjct: 473 KEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPST------ 526
Query: 3898 IAEIMIEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGAVNVYWKA 3957
A + I + DD GIF F E +T V + +++V V+R +G+ G V V +K
Sbjct: 527 -ATVTIFD-DDHAGIFTFE------EPVT--HVSESIGIMEVKVLRTSGARGNVIVPYKT 576
Query: 3958 SPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISL 4005
+A G EDF+ + G LEF + ++ +I I I D E+E +F++ L
Sbjct: 577 IEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 64.3 bits (155), Expect = 4e-09
Identities = 63/228 (27%), Positives = 92/228 (40%), Gaps = 27/228 (11%)
Query: 1587 EEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLN 1646
E T++ + R G D + + + E DG D+ GT+ F P + +
Sbjct: 420 ENCGTVALTIIRRGG--DLTNTVFVDFRTE-DGTANAGSDYEFTEGTVVFKPGDTQKEIR 476
Query: 1647 IYVLDDDIPELNEYF-----RVTLVSAIPGDGKLGSTPTSGASIDPEKETTDITIKASDH 1701
+ ++DDDI E +E F V + S DG L + S + T +TI DH
Sbjct: 477 VGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDH 536
Query: 1702 PYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQGLLGRVTAEFRTVS 1761
G+ F P V E G + + V+R G G V ++T+
Sbjct: 537 A-GIFTFEE-----------------PVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIE 578
Query: 1762 LTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKVEL 1808
TA ED+++ G LEFQ E K I I I D E E SF + L
Sbjct: 579 GTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 62.8 bits (151), Expect = 1e-08
Identities = 61/199 (30%), Positives = 85/199 (42%), Gaps = 33/199 (16%)
Query: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISAS- 2553
G A AGSDYE T + + GD + V I+ DD E DE+FL VHL N+ S
Sbjct: 449 GTANAGSDYE-FTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFL-----VHLSNVKVSS 502
Query: 2554 ------------LKNQPTIGQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQ 2601
+ +G P+ +TV I + D G+F + SE
Sbjct: 503 EASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAGIFTFEEPVTHVSES--------- 552
Query: 2602 PQTLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTIL 2660
++E+ + RT G+ G V V ++ + GTA G DF L F E K + + I
Sbjct: 553 -IGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIF 611
Query: 2661 DDSEPEDDESIIVSLVYTE 2679
D E E + S SLV E
Sbjct: 612 DREEYEKECSF--SLVLEE 628
Score = 62.0 bits (149), Expect = 2e-08
Identities = 60/214 (28%), Positives = 98/214 (45%), Gaps = 23/214 (10%)
Query: 4171 GTAIISLVR-GPGILGEVTVFWRIFPPSVG---EFAETSGKLTMRDEQSAVIVVIQALND 4226
GT ++++R G + V V +R + ++ T G + + + + + ++D
Sbjct: 423 GTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDD 482
Query: 4227 DIPEEKSFYEFQLTAV------SEGGVLSE----------SSSTANITVVASDSPYGRFA 4270
DI EE + L+ V SE G+L S STA +T+ D G F
Sbjct: 483 DIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHA-GIFT 541
Query: 4271 FSHEQLRVSEAQRV-NITIIRSSGDFGHVRLWYKTMSGTAEAG-LDFVPAAGELLFEAGE 4328
F VSE+ + + ++R+SG G+V + YKT+ GTA G DF GEL F+ E
Sbjct: 542 FEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDE 601
Query: 4329 MRKSLHVEILDDDYPEGPEEFSLTITKVELQGRG 4362
+ K + + I D + E FSL + + + RG
Sbjct: 602 IVKIITIRIFDREEYEKECSFSLVLEEPKWIRRG 635
Score = 60.8 bits (146), Expect = 4e-08
Identities = 58/204 (28%), Positives = 92/204 (45%), Gaps = 22/204 (10%)
Query: 2606 VELMIHRTGGSL-GQVAVEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664
V L I R GG L V V++R GTA G D+ + F G+T+K + + I+DD
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 2665 PEDDESIIVSLVYTEGGSR----------------ILPSSDTVRVNILANDNVAGIVSFQ 2708
E+DE+ +V L + S L S T V I +D+ AGI +F+
Sbjct: 485 FEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDH-AGIFTFE 543
Query: 2709 TASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKII---GQNLELNFANFSGQLFFPEGSL 2765
V G I++ V+RT RGNV V +K I + +F + G+L F +
Sbjct: 544 EPVTHVSESIG-IMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEI 602
Query: 2766 NTTLFVHLLDDNIPEEKEVYQVIL 2789
+ + + D E++ + ++L
Sbjct: 603 VKIITIRIFDREEYEKECSFSLVL 626
Score = 60.5 bits (145), Expect = 5e-08
Identities = 65/247 (26%), Positives = 98/247 (39%), Gaps = 27/247 (10%)
Query: 1968 TVLASDDPYGIFIFSEKNRPVKVEEATQNITLSIIRLKG-LMGKVLVSYATLDDMEKPPY 2026
T + +DP F + + E + L+IIR G L V V + T D
Sbjct: 398 TEVTENDPVSKIFFEQGT--YQCLENCGTVALTIIRRGGDLTNTVFVDFRTED------- 448
Query: 2027 FPPNLARATQGRDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAK 2086
A G DY G +F ++ I + I+DDD E E+ + L N K
Sbjct: 449 -----GTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSN----VK 499
Query: 2087 VQSRSIPNSPRLGPKVETIAQL-------IIIANDDAFGTLQLSAPIVRVAENHVGPIIN 2139
V S + + V T+A L + I +DD G P+ V+E+ +
Sbjct: 500 VSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVK 559
Query: 2140 VTRTGGAFADVSVKFKAVPITAI-AGEDYSIASSDVVLLEGETSKAVPIYVINDIYPELE 2198
V RT GA +V V +K + TA GED+ ++ E K + I + + E E
Sbjct: 560 VLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKE 619
Query: 2199 ESFLVQL 2205
SF + L
Sbjct: 620 CSFSLVL 626
Score = 57.4 bits (137), Expect = 4e-07
Identities = 60/218 (27%), Positives = 92/218 (42%), Gaps = 38/218 (17%)
Query: 1884 TVTLNVIRHHGTLS-PVTLHWNID---SDPDGDLAFTSGNITFEIGQTSANITVEILPDE 1939
TV L +IR G L+ V + + + ++ D FT G + F+ G T I V I+ D+
Sbjct: 424 TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
Query: 1940 DPELDKAFSVSVLSVSSGS------------------LGAHINATLTVLASDDPYGIFIF 1981
E D+ F V + +V S LG+ AT+T+ DD GIF F
Sbjct: 484 IFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIF-DDDHAGIFTF 542
Query: 1982 SEKNRPV-KVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQGRDY 2040
E PV V E+ + + ++R G G V+V Y T++ + G D+
Sbjct: 543 EE---PVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTAR-----------GGGEDF 588
Query: 2041 IPASGFALFGANQSEATIAISILDDDEPERSESVFIEL 2078
G F ++ I I I D +E E+ S + L
Sbjct: 589 EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 57.4 bits (137), Expect = 4e-07
Identities = 54/190 (28%), Positives = 82/190 (43%), Gaps = 26/190 (13%)
Query: 2138 INVTRTGGAFAD-VSVKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDIYPE 2196
+ + R GG + V V F+ TA AG DY VV G+T K + + +I+D E
Sbjct: 427 LTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFE 486
Query: 2197 LEESFLVQLMNETTGG----------------ARLGALTEAVIIIEASDDPYGLFGFQIT 2240
+E+FLV L N A LG+ + A + I DD G+F F+
Sbjct: 487 EDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAGIFTFEEP 545
Query: 2241 KLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVVSGNVTFAPG 2297
V E S+ + + ++R SG GNV V + TI G G D G + F
Sbjct: 546 VTHVSE----SIGIMEVKVLRTSGARGNVIVPY-KTIEGTARGGGEDFEDTCGELEFQND 600
Query: 2298 ETIQTLLLEV 2307
E ++ + + +
Sbjct: 601 EIVKIITIRI 610
Score = 56.2 bits (134), Expect = 1e-06
Identities = 55/194 (28%), Positives = 86/194 (44%), Gaps = 23/194 (11%)
Query: 1017 GETANFTVLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFV 1076
G A + R G + T V + T+DG A A D+ E T++F+ G Q+ I + +
Sbjct: 423 GTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS-DYEFTE--GTVVFKPGDTQKEIRVGI 479
Query: 1077 NEDGIPETDEPFYIILLNSTGDTVVYQYGV-----------------ATVIIEANDDPNG 1119
+D I E DE F + L N + + G+ ATV I +DD G
Sbjct: 480 IDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTI-FDDDHAG 538
Query: 1120 IFSL-EPIDKAVEEGKTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNF 1178
IF+ EP+ E +LR G G+V V ++ + +A G++F +T G + F
Sbjct: 539 IFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEG-TARGGGEDFEDTCGELEF 597
Query: 1179 MDGEEAKPIILHAF 1192
+ E K I + F
Sbjct: 598 QNDEIVKIITIRIF 611
Score = 56.2 bits (134), Expect = 1e-06
Identities = 44/161 (27%), Positives = 72/161 (44%), Gaps = 27/161 (16%)
Query: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAE----------- 3633
SD+ + G ++F+PG+ + I V I+DD + E++E+F V L N K +E
Sbjct: 455 SDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANH 514
Query: 3634 ------IGINDSVTITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGTYGR 3687
+G + T+TI +D A GI F + + E ++ + V R G G
Sbjct: 515 VSTLACLGSPSTATVTIFDDDHA-GIFTFEEPVTHVS----ESIGIMEVKVLRTSGARGN 569
Query: 3688 I-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTI 3723
+ TI A G D T G + F +++ IT+ I
Sbjct: 570 VIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRI 610
Score = 54.3 bits (129), Expect = 4e-06
Identities = 52/221 (23%), Positives = 90/221 (40%), Gaps = 8/221 (3%)
Query: 2962 IEWQQSRFEVNETHGSLTL-VAQRSREPLGHVSLFVYAQNLEAQVGLDYIFTPMILHFAD 3020
I ++Q ++ E G++ L + +R + V + ++ A G DY FT + F
Sbjct: 409 IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKP 468
Query: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNPSPGLE------LGKNTIALIIVLANDDGPG 3074
G+ K + + I+DDDI E DE F + L+N E L N ++ + L +
Sbjct: 469 GDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTAT 528
Query: 3075 VLSFNNSE-HFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSSNESKDL 3133
V F++ F E +V ES+ ++ + G G V V + E + +D
Sbjct: 529 VTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDF 588
Query: 3134 TPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
+ G + + K + I E E + F L P
Sbjct: 589 EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEP 629
Score = 46.6 bits (109), Expect = 8e-04
Identities = 44/170 (25%), Positives = 75/170 (44%), Gaps = 12/170 (7%)
Query: 2891 GFLILEEGETAAAINITILEDDVPELEEYFLVNLTYV---------GLTMAASTSFPPRL 2941
G ++ + G+T I + I++DD+ E +E FLV+L+ V G+ A S L
Sbjct: 462 GTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACL 521
Query: 2942 DSEGLTAQVIIDANDGARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQN 3000
S I D D G+ +++ V+E+ G + + R+ G+V + + +
Sbjct: 522 GSPSTATVTIFD--DDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEG 579
Query: 3001 LEAQVGLDYIFTPMILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
G D+ T L F + E K + I I D + E + F L+L P
Sbjct: 580 TARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEP 629
Score = 45.4 bits (106), Expect = 0.002
Identities = 42/174 (24%), Positives = 74/174 (42%), Gaps = 24/174 (13%)
Query: 2239 ITKLIVEEPEFNSVK----VNLPIIRNSGTLGNVTVQWVATINGQLATG-DLRVVSGNVT 2293
++K+ E+ + ++ V L IIR G L N T +G G D G V
Sbjct: 406 VSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVV 465
Query: 2294 FAPGETIQTLLLEVLADDVPEIEEVIQVQL------TDASGGGTIGLDRIANI------- 2340
F PG+T + + + ++ DD+ E +E V L ++AS G + + ++ +
Sbjct: 466 FKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPS 525
Query: 2341 ---IIPANDDPYGTVAFAQMVYRVQEPLERSSCANITVRRSGGHFGRLLLFYST 2391
+ +DD G F + V V E + + V R+ G G +++ Y T
Sbjct: 526 TATVTIFDDDHAGIFTFEEPVTHVSESI---GIMEVKVLRTSGARGNVIVPYKT 576
Score = 43.9 bits (102), Expect = 0.005
Identities = 25/80 (31%), Positives = 39/80 (48%), Gaps = 1/80 (1%)
Query: 166 SMPLTLIREKGTY-GMVMVTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDE 224
++ LT+IR G V V F E G D +G + F PG + ++DD+
Sbjct: 424 TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDD 483
Query: 225 VPENDEIFLIQLKSVEGGAE 244
+ E DE FL+ L +V+ +E
Sbjct: 484 IFEEDENFLVHLSNVKVSSE 503
Score = 42.4 bits (98), Expect = 0.015
Identities = 55/243 (22%), Positives = 93/243 (38%), Gaps = 39/243 (16%)
Query: 3903 IEENDDPRGIFMFHVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSF-GAVNVYWKASPDS 3961
+ END IF T Y+ + + ++R G V V ++ +
Sbjct: 400 VTENDPVSKIFFEQGT---------YQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGT 450
Query: 3962 AGL-EDFKPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGGGRLGDDVVV 4020
A D++ + G + F I + IIDD FE E F + L +V +D ++
Sbjct: 451 ANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGIL 510
Query: 4021 -----------------TVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRS 4063
TV I +D G+F FEE + ES+ + + V+R+
Sbjct: 511 EANHVSTLACLGSPSTATVTIFDDDHA-GIFTFEEPVTHVSESI------GIMEVKVLRT 563
Query: 4064 PGGKGTVRLEW-TIDEKAK---HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFT 4119
G +G V + + TI+ A+ + G L F E K I + E++ F+
Sbjct: 564 SGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFS 623
Query: 4120 IQL 4122
+ L
Sbjct: 624 LVL 626
Score = 42.0 bits (97), Expect = 0.019
Identities = 62/266 (23%), Positives = 104/266 (39%), Gaps = 40/266 (15%)
Query: 248 SRNSIEIIIKKND--SPVRFLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYEVSISY 305
S + + + +ND S + F Q Y E + + ++R + N + D
Sbjct: 392 SMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVD-------- 443
Query: 306 AVTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKD 365
T + TA+A + +F + TVVF P + ++ I+DD I E E+F + L
Sbjct: 444 -FRTEDGTANAGSDYEFTE----GTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNV 498
Query: 366 TLQGD---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDR 410
+ + A L SPS VTI +D G+ + FE V +
Sbjct: 499 KVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHA-GIFT-----FEEPVTHVSES 552
Query: 411 ISRYEEITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLT 470
I E+ V+R G GNV + + D + G L F +++ I +
Sbjct: 553 IG-IMEVKVLRTSGARGNVIVPYKTIEGTARGG--GEDFEDTCGELEFQNDEIVKIITIR 609
Query: 471 VVD-DDLPEEAEAYLLQILPHTIRGG 495
+ D ++ +E L+ P IR G
Sbjct: 610 IFDREEYEKECSFSLVLEEPKWIRRG 635
Score = 42.0 bits (97), Expect = 0.019
Identities = 64/238 (26%), Positives = 98/238 (41%), Gaps = 36/238 (15%)
Query: 766 ILENDDPGGVFEFSPASRGPYVIKEG-ESVELHIIRSRGSLVKQ-FLHYRVEPRDSN--- 820
+ END +F +G Y E +V L IIR G L F+ +R E +N
Sbjct: 400 VTENDPVSKIF----FEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGS 455
Query: 821 EFYGNTGVLEFKPGEREIVITLLARLDGIPELDEHYWVVLS----------------SHG 864
++ G + FKPG+ + I + D I E DE++ V LS +H
Sbjct: 456 DYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHV 515
Query: 865 ERESKLGSATIVNITILKNDDPHGIIEFVSDGLIVMINESKGDAIYSAVYDVVRNRGNFG 924
+ LGS + +TI +DD GI F + + ++ES G V+R G G
Sbjct: 516 STLACLGSPSTATVTIF-DDDHAGIFTF--EEPVTHVSESIG----IMEVKVLRTSGARG 568
Query: 925 DVSVSWVVSPDFT----QDVFPVQGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVIL 978
+V V + +D G + F + E K ITI E E+ F+++L
Sbjct: 569 NVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 40.0 bits (92), Expect = 0.073
Identities = 47/180 (26%), Positives = 76/180 (42%), Gaps = 23/180 (12%)
Query: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558
A SD G + F+ G+T K + DD+ E +E F++ L +V + SE+
Sbjct: 453 AGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEA 512
Query: 1559 ------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERTRGALDYV 1606
+TA +TI D+A G+F F + ++E + V RT GA V
Sbjct: 513 NHVSTLACLGSPSTATVTIFDDDHA-GIFTFEEP-VTHVSESIGIMEVKVLRTSGARGNV 570
Query: 1607 HVFY-TISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELNEYFRVTL 1665
V Y TI G +DF + G + F + +++ I + D + E F + L
Sbjct: 571 IVPYKTIEGTARGG----GEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVL 626
Score = 38.5 bits (88), Expect = 0.21
Identities = 45/186 (24%), Positives = 75/186 (40%), Gaps = 18/186 (9%)
Query: 673 VYIPLHRDGTDGQATVYWSLKPSGFNSKAVTPDDIGPFNGSVLFLSGQSDTTINITIKGD 732
V + + R G D TV+ + + A + D G+V+F G + I + I D
Sbjct: 425 VALTIIRRGGDLTNTVFVDFRTEDGTANAGS--DYEFTEGTVVFKPGDTQKEIRVGIIDD 482
Query: 733 DIPEMNETVTLSLDRVNVENQVLKSGY--------------TSRDLIILENDDPGGVFEF 778
DI E +E + L V V ++ + G S + + +DD G+F F
Sbjct: 483 DIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTF 542
Query: 779 -SPASRGPYVIKEGESVELHIIRSRGSLVKQFLHYRVEPRDSNEFYGNT-GVLEFKPGER 836
P + I E L +RG+++ + R E + +T G LEF+ E
Sbjct: 543 EEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEI 602
Query: 837 EIVITL 842
+IT+
Sbjct: 603 VKIITI 608
Score = 37.7 bits (86), Expect = 0.36
Identities = 52/238 (21%), Positives = 101/238 (42%), Gaps = 34/238 (14%)
Query: 4020 VTVVIPQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGG-KGTVRLEWTIDE 4078
V + +ND +F FE+ T E+ + V LT++R G TV +++ ++
Sbjct: 396 VNTEVTENDPVSKIF-FEQGTYQCLENCGT------VALTIIRRGGDLTNTVFVDFRTED 448
Query: 4079 ---KAKHNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKG 4135
A + GT+ F ++QK I + + D + EED F L+ + V++S
Sbjct: 449 GTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENF---LVHLSNVKVSSEAS 505
Query: 4136 SASIIIRGDKRASGEVGIAPSSRHILI-----------GEPSAKYN---GTAIISLVRGP 4181
I+ +G +PS+ + I EP + G + ++R
Sbjct: 506 EDGILEANHVSTLACLG-SPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS 564
Query: 4182 GILGEVTVFWRIFPPSV----GEFAETSGKLTMRDEQSAVIVVIQALN-DDIPEEKSF 4234
G G V V ++ + +F +T G+L ++++ I+ I+ + ++ +E SF
Sbjct: 565 GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFDREEYEKECSF 622
Score = 35.4 bits (80), Expect = 1.8
Identities = 37/128 (28%), Positives = 52/128 (40%), Gaps = 19/128 (14%)
Query: 944 QGTVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILLNGTGGAK----------------- 986
+GTVVF + K I + + D+I EE E F V L N ++
Sbjct: 461 EGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLAC 520
Query: 987 VGNRTTATLRIRRNDDP-IYFAEPRVVRVQEG-ETANFTVLRNGSVDVTCMVQYATKDGK 1044
+G+ +TAT+ I +D I+ E V V E VLR +V Y T +G
Sbjct: 521 LGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGT 580
Query: 1045 ATARERDF 1052
A DF
Sbjct: 581 ARGGGEDF 588
Score = 34.3 bits (77), Expect = 4.0
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 25/159 (15%)
Query: 417 ITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDL 476
+T++R GG N +V R + +D + G + F G I + ++DDD+
Sbjct: 427 LTIIRRGGDLTNTV--FVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDI 484
Query: 477 PEEAEAYLLQILPHTIRGGAEVSE-----------------PAELLFYIQDSDDVYGLIT 519
EE E +L+ + ++ +E SE P+ I D DD G+ T
Sbjct: 485 FEEDENFLVHL--SNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFD-DDHAGIFT 541
Query: 520 FFPMENQKIESSPGERYLSLSFTRLGGTKGDVRLLYSVL 558
F E S + + R G +G+V + Y +
Sbjct: 542 F---EEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTI 577
Score = 34.3 bits (77), Expect = 4.0
Identities = 17/52 (32%), Positives = 31/52 (59%)
Query: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEE 5344
D+E T++F G+ ++++ V I+DDD E E F V L+N + ++ E+
Sbjct: 456 DYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASED 507
>gi|74048357 G protein-coupled receptor 126 alpha 1 precursor [Homo
sapiens]
Length = 1221
Score = 83.2 bits (204), Expect = 8e-15
Identities = 95/411 (23%), Positives = 173/411 (42%), Gaps = 59/411 (14%)
Query: 5796 QFTEYSSQQWFIS-GNNLPTLKNKVLSLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTS 5854
QFT ++ F G TL + V++ S+ + Q L + ++ + + P
Sbjct: 745 QFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHHP--- 801
Query: 5855 LCLLW----NQAAASWLSDSQFCKVVEETADYVECACSHMSVYAVYARTDNLSSYNEAFF 5910
+C W N++ W + + ++ V C C+H + + V +S +A
Sbjct: 802 ICAFWDLNKNKSFGGWNTSGCVAHRDSDASETV-CLCNHFTHFGVLMDLPRSASQLDARN 860
Query: 5911 TSGFICISGLCLAVLSHIFCARYSM-----------FAAKLLTHMMAASLGTQILFLASA 5959
T IS + + S IF A + + +K+L ++ A L +LFL
Sbjct: 861 TKVLTFISYIGCGI-SAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDG 919
Query: 5960 YASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL-FFLLSW 6018
+ + + C A+A + H+ L F+WM +++++ + LV RRY+L F ++ W
Sbjct: 920 WITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIIGW 979
Query: 6019 GLPAFVVILLIVILKG--IYHQSMSQIYGLIHGD-LCFIPNVYAALFTAA-------LVP 6068
GLPA VV +++ +Y + + YG GD C+I + T A +
Sbjct: 980 GLPALVVSVVLASRNNNEVYGK---ESYGKEKGDEFCWIQDPVIFYVTCAGYFGVMFFLN 1036
Query: 6069 LTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTW-----LWGG 6123
+ +VV V + ++V R + ++ L L+ +TW WG
Sbjct: 1037 IAMFIVVMVQICGRNGKRSNRTLREEVLR------NLRSVVSLTFLLGMTWGFAFFAWGP 1090
Query: 6124 LHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQMCCPMKASYTVEMNGH 6174
L++ + + LF IFNSLQGL++F+ + C MK + + H
Sbjct: 1091 LNIPF-----MYLFSIFNSLQGLFIFIFH--------CAMKENVQKQWRRH 1128
>gi|50355941 G protein-coupled receptor 126 beta 1 precursor [Homo
sapiens]
Length = 1250
Score = 83.2 bits (204), Expect = 8e-15
Identities = 95/411 (23%), Positives = 173/411 (42%), Gaps = 59/411 (14%)
Query: 5796 QFTEYSSQQWFIS-GNNLPTLKNKVLSLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTS 5854
QFT ++ F G TL + V++ S+ + Q L + ++ + + P
Sbjct: 745 QFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHHP--- 801
Query: 5855 LCLLW----NQAAASWLSDSQFCKVVEETADYVECACSHMSVYAVYARTDNLSSYNEAFF 5910
+C W N++ W + + ++ V C C+H + + V +S +A
Sbjct: 802 ICAFWDLNKNKSFGGWNTSGCVAHRDSDASETV-CLCNHFTHFGVLMDLPRSASQLDARN 860
Query: 5911 TSGFICISGLCLAVLSHIFCARYSM-----------FAAKLLTHMMAASLGTQILFLASA 5959
T IS + + S IF A + + +K+L ++ A L +LFL
Sbjct: 861 TKVLTFISYIGCGI-SAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDG 919
Query: 5960 YASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL-FFLLSW 6018
+ + + C A+A + H+ L F+WM +++++ + LV RRY+L F ++ W
Sbjct: 920 WITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIIGW 979
Query: 6019 GLPAFVVILLIVILKG--IYHQSMSQIYGLIHGD-LCFIPNVYAALFTAA-------LVP 6068
GLPA VV +++ +Y + + YG GD C+I + T A +
Sbjct: 980 GLPALVVSVVLASRNNNEVYGK---ESYGKEKGDEFCWIQDPVIFYVTCAGYFGVMFFLN 1036
Query: 6069 LTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTW-----LWGG 6123
+ +VV V + ++V R + ++ L L+ +TW WG
Sbjct: 1037 IAMFIVVMVQICGRNGKRSNRTLREEVLR------NLRSVVSLTFLLGMTWGFAFFAWGP 1090
Query: 6124 LHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQMCCPMKASYTVEMNGH 6174
L++ + + LF IFNSLQGL++F+ + C MK + + H
Sbjct: 1091 LNIPF-----MYLFSIFNSLQGLFIFIFH--------CAMKENVQKQWRRH 1128
>gi|74048422 G protein-coupled receptor 126 alpha 2 precursor [Homo
sapiens]
Length = 1193
Score = 83.2 bits (204), Expect = 8e-15
Identities = 95/411 (23%), Positives = 173/411 (42%), Gaps = 59/411 (14%)
Query: 5796 QFTEYSSQQWFIS-GNNLPTLKNKVLSLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTS 5854
QFT ++ F G TL + V++ S+ + Q L + ++ + + P
Sbjct: 717 QFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHHP--- 773
Query: 5855 LCLLW----NQAAASWLSDSQFCKVVEETADYVECACSHMSVYAVYARTDNLSSYNEAFF 5910
+C W N++ W + + ++ V C C+H + + V +S +A
Sbjct: 774 ICAFWDLNKNKSFGGWNTSGCVAHRDSDASETV-CLCNHFTHFGVLMDLPRSASQLDARN 832
Query: 5911 TSGFICISGLCLAVLSHIFCARYSM-----------FAAKLLTHMMAASLGTQILFLASA 5959
T IS + + S IF A + + +K+L ++ A L +LFL
Sbjct: 833 TKVLTFISYIGCGI-SAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDG 891
Query: 5960 YASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL-FFLLSW 6018
+ + + C A+A + H+ L F+WM +++++ + LV RRY+L F ++ W
Sbjct: 892 WITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIIGW 951
Query: 6019 GLPAFVVILLIVILKG--IYHQSMSQIYGLIHGD-LCFIPNVYAALFTAA-------LVP 6068
GLPA VV +++ +Y + + YG GD C+I + T A +
Sbjct: 952 GLPALVVSVVLASRNNNEVYGK---ESYGKEKGDEFCWIQDPVIFYVTCAGYFGVMFFLN 1008
Query: 6069 LTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTW-----LWGG 6123
+ +VV V + ++V R + ++ L L+ +TW WG
Sbjct: 1009 IAMFIVVMVQICGRNGKRSNRTLREEVLR------NLRSVVSLTFLLGMTWGFAFFAWGP 1062
Query: 6124 LHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQMCCPMKASYTVEMNGH 6174
L++ + + LF IFNSLQGL++F+ + C MK + + H
Sbjct: 1063 LNIPF-----MYLFSIFNSLQGLFIFIFH--------CAMKENVQKQWRRH 1100
>gi|74048403 G protein-coupled receptor 126 beta 2 precursor [Homo
sapiens]
Length = 1222
Score = 83.2 bits (204), Expect = 8e-15
Identities = 95/411 (23%), Positives = 173/411 (42%), Gaps = 59/411 (14%)
Query: 5796 QFTEYSSQQWFIS-GNNLPTLKNKVLSLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTS 5854
QFT ++ F G TL + V++ S+ + Q L + ++ + + P
Sbjct: 717 QFTFFNKTGLFQDVGPQRKTLVSYVMACSIGNITIQNLKDPVQIKIKHTRTQEVHHP--- 773
Query: 5855 LCLLW----NQAAASWLSDSQFCKVVEETADYVECACSHMSVYAVYARTDNLSSYNEAFF 5910
+C W N++ W + + ++ V C C+H + + V +S +A
Sbjct: 774 ICAFWDLNKNKSFGGWNTSGCVAHRDSDASETV-CLCNHFTHFGVLMDLPRSASQLDARN 832
Query: 5911 TSGFICISGLCLAVLSHIFCARYSM-----------FAAKLLTHMMAASLGTQILFLASA 5959
T IS + + S IF A + + +K+L ++ A L +LFL
Sbjct: 833 TKVLTFISYIGCGI-SAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDG 891
Query: 5960 YASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL-FFLLSW 6018
+ + + C A+A + H+ L F+WM +++++ + LV RRY+L F ++ W
Sbjct: 892 WITSFNVDGLCIAVAVLLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIIGW 951
Query: 6019 GLPAFVVILLIVILKG--IYHQSMSQIYGLIHGD-LCFIPNVYAALFTAA-------LVP 6068
GLPA VV +++ +Y + + YG GD C+I + T A +
Sbjct: 952 GLPALVVSVVLASRNNNEVYGK---ESYGKEKGDEFCWIQDPVIFYVTCAGYFGVMFFLN 1008
Query: 6069 LTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTW-----LWGG 6123
+ +VV V + ++V R + ++ L L+ +TW WG
Sbjct: 1009 IAMFIVVMVQICGRNGKRSNRTLREEVLR------NLRSVVSLTFLLGMTWGFAFFAWGP 1062
Query: 6124 LHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQMCCPMKASYTVEMNGH 6174
L++ + + LF IFNSLQGL++F+ + C MK + + H
Sbjct: 1063 LNIPF-----MYLFSIFNSLQGLFIFIFH--------CAMKENVQKQWRRH 1100
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [Homo
sapiens]
Length = 1584
Score = 82.8 bits (203), Expect = 1e-14
Identities = 99/446 (22%), Positives = 184/446 (41%), Gaps = 51/446 (11%)
Query: 5768 GDYIRIPERLLDVQDAEIMAG-----KSTCKLVQFTEYSSQQWFIS-GNNLPTLKNKVLS 5821
GD+ ++PE + V + G +++ +V Y + F++ N L +KV+S
Sbjct: 795 GDWAKVPEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLALQRNTTVLNSKVIS 854
Query: 5822 LSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTSLCLLWNQAAA------------SWLSD 5869
++VK L T +Y C+LW++ SW
Sbjct: 855 VTVKPPPRSLRTPLEIEFAHMYNGTTN-----QTCILWDETDVPSSSAPPQLGPWSWRG- 908
Query: 5870 SQFCKVVEETADYVECACSHMSVYAVYARTDNLSSYNEAFFTSGFICI----SGLCLAVL 5925
C+ V A C C +S +A+ A+ ++ +A S + + S L L +L
Sbjct: 909 ---CRTVPLDALRTRCLCDRLSTFAILAQLSADANMEKATLPSVTLIVGCGVSSLTLLML 965
Query: 5926 SHIFCARYSMFAAK---LLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYLYL 5982
I+ + + ++ +L + + + + L L + + C+ +AA H+ +L
Sbjct: 966 VIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTRN--KVVCTLVAAFLHFFFL 1023
Query: 5983 CQFSWMLIQSVNFWYVLVMNDEHTERRYLL--FFLLSWGLPAFVVILLIVILKGIYHQSM 6040
F W+L ++ W + H R + F L WGLPA VV + + K + +M
Sbjct: 1024 SSFCWVLTEA---WQSYMAVTGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYSTM 1080
Query: 6041 SQIYGLIHGDLCFIPNVYAALFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRGRT 6100
+ + + G L +YA + AA V L +V+ +VF ++ + D + R
Sbjct: 1081 NYCWLSLEGGL-----LYAFVGPAAAVVLVNMVIGILVF---NKLVSKDGITDKKLKERA 1132
Query: 6101 NAAEIPLILYLFALISVTWLWGGLHMAYRHFWML-VLFVIFNSLQGLYVFMVYFILHNQM 6159
A+ + L L+++TW+ L + R + +LF +F+SL+G + MV+ IL ++
Sbjct: 1133 GASLWSSCVVL-PLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREV 1191
Query: 6160 CCPMKASYTVEMNGHPGPSTAFFTPG 6185
+K G S F G
Sbjct: 1192 QDAVKCRVVDRQEEGNGDSGGSFQNG 1217
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 82.4 bits (202), Expect = 1e-14
Identities = 102/450 (22%), Positives = 193/450 (42%), Gaps = 54/450 (12%)
Query: 5838 VLYRIYAAEPRIIPQTSLCLLWNQAAA-----SWLSDSQFCKVVEETADYVECACSHMSV 5892
V + + E R P +C+ WN + A W ++ C+++ +V C CSH +
Sbjct: 2396 VEFALLEVEERTKP---VCVFWNHSLAVGGTGGW--SARGCELLSRNRTHVACQCSHTAS 2450
Query: 5893 YAVY---ARTDNLSSYNEAFFTSGFICISGLCLAVLSHIFCARYSMFAAKLLT---HMMA 5946
+AV +R +N T + +S L +++ + + M + L + H+
Sbjct: 2451 FAVLMDISRRENGEVLPLKIVTYAAVSLS-LAALLVAFVLLSLVRMLRSNLHSIHKHLAV 2509
Query: 5947 ASLGTQILFLA--SAYASPQLAEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVL--VMN 6002
A +Q++F+ + +P L C+ +A + HY+Y+ F+W L++S++ + +L V N
Sbjct: 2510 ALFLSQLVFVIGINQTENPFL----CTVVAILLHYIYMSTFAWTLVESLHVYRMLTEVRN 2565
Query: 6003 DEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQSMSQIYGLIHGDLCFIPNVYAALF 6062
+ R+ ++++ WG+PA V L + G+ Q YG + D C++ ++ L
Sbjct: 2566 IDTGPMRF--YYVVGWGIPAIVTGLAV----GLDPQG----YG--NPDFCWL-SLQDTLI 2612
Query: 6063 TAALVPLTCLVVV-FVVFIHAYQVKPQWKAYDDVFRGRTNAAEIPLILYLFALISVTWLW 6121
+ P+ ++++ V + + +V Q K + +G + +L L LIS TWL
Sbjct: 2613 WSFAGPIGAVIIINTVTSVLSAKVSCQRKHHYYGKKGIVSLLRTAFLLLL--LISATWLL 2670
Query: 6122 GGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILHNQMCCPMKA-----------SYTVE 6170
G L + LF IF+ LQG +V + + +L+ ++ +K S T
Sbjct: 2671 GLLAVNRDALSFHYLFAIFSGLQGPFVLLFHCVLNQEVRKHLKGVLGGRKLHLEDSATTR 2730
Query: 6171 MNGHPGPSTAFFTPGSGMPPAGGEISKSTQNL--IGAMEEVPPDWERASFQQGSQASPDL 6228
T G G ++ +ST +L I E + + +GS PD
Sbjct: 2731 ATLLTRSLNCNTTFGDGPDMLRTDLGESTASLDSIVRDEGIQKLGVSSGLVRGSHGEPDA 2790
Query: 6229 KPSPQNGATFPSSGGYGQGSLIADEESQEF 6258
P++ P L DE+S +
Sbjct: 2791 SLMPRSCKDPPGHDSDSDSELSLDEQSSSY 2820
>gi|45433552 G protein-coupled receptor 133 [Homo sapiens]
Length = 874
Score = 81.6 bits (200), Expect = 2e-14
Identities = 69/308 (22%), Positives = 133/308 (43%), Gaps = 32/308 (10%)
Query: 5873 CKVVEETADYVECACSHMSVYAVYARTDNLS---SYNEAFFTSGFI--CISGLCL----- 5922
C + Y C C+H++ +A+ + L + A + ++ +S LCL
Sbjct: 527 CALTRGNLTYSVCRCTHLTNFAILMQVVPLELARGHQVALSSISYVGCSLSVLCLVATLV 586
Query: 5923 --AVLSHIFCARYSMFAAKLLTHMMAASLGTQILFLASAYASPQLAEESCSAMAAVTHYL 5980
AVLS + R + + ++ A L Q+L L S P C MA + HY
Sbjct: 587 TFAVLSSVSTIRNQRY--HIHANLSFAVLVAQVLLLISFRLEP--GTTPCQVMAVLLHYF 642
Query: 5981 YLCQFSWMLIQSVNFW--YVLVMNDEHTERRYLLFFLLSWGLPAFVVILLIVILKGIYHQ 6038
+L F+WML++ ++ + + V E ++ RY ++ + WG P + I+ + Y
Sbjct: 643 FLSAFAWMLVEGLHLYSMVIKVFGSEDSKHRY--YYGMGWGFPLLICIISLSFAMDSYGT 700
Query: 6039 SMSQIYGLIHGDLCFIPNVYAALFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYDDVFRG 6098
S + C++ A++ L +VV + I +V Q A + G
Sbjct: 701 SNN----------CWLSLASGAIWAFVAPALFVIVVNIGILIAVTRVISQISADNYKIHG 750
Query: 6099 RTNAAEI--PLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYFILH 6156
+A ++ + L ++ +W++G L + +F NSLQGL++F+ + +L+
Sbjct: 751 DPSAFKLTAKAVAVLLPILGTSWVFGVLAVNGCAVVFQYMFATLNSLQGLFIFLFHCLLN 810
Query: 6157 NQMCCPMK 6164
+++ K
Sbjct: 811 SEVRAAFK 818
>gi|133930786 egf-like module-containing mucin-like receptor 3 [Homo
sapiens]
Length = 652
Score = 80.9 bits (198), Expect = 4e-14
Identities = 96/426 (22%), Positives = 172/426 (40%), Gaps = 39/426 (9%)
Query: 5756 QQINGHKFEGKEGDYIRIPERLLDVQDAEIMAGKSTC-KLVQFTEYSSQQWFISGNNLPT 5814
Q I + E ++ + + +D++ ++I+ G + + F YSS I+
Sbjct: 197 QAITDNCSEERKTFNLNVQMNSMDIRCSDIIQGDTQGPSAIAFISYSSLGNIINATFFEE 256
Query: 5815 LKNK--------VLSLSVKGQSSQLLTNDNEVLYRIYAAEPRIIPQTS--LCLLWNQAA- 5863
+ K V+S ++ + + L+ + ++ ++ P T C+ W
Sbjct: 257 MDKKDQVYLNSQVVSAAIGPKRNVSLSKSVTLTFQ----HVKMTPSTKKVFCVYWKSTGQ 312
Query: 5864 -ASWLSDSQFCKVVEETADYVECACSHMSVYAVY-ARTDNLSSYNEAFFTSGFICISGLC 5921
+ W D C ++ + C CSH+S +AV A T T + +S LC
Sbjct: 313 GSQWSRDG--CFLIHVNKSHTMCNCSHLSSFAVLMALTSQEEDPVLTVITYVGLSVSLLC 370
Query: 5922 L--AVLSHIFCARYSMFAAKLLTHMMAASLGTQILFLASA-YASPQLAEESCSAMAAVTH 5978
L A L+ + C + L + +LFL P++ CS +A H
Sbjct: 371 LLLAALTFLLCKAIRNTSTSLHLQLSLCLFLAHLLFLVGIDRTEPKVL---CSIIAGALH 427
Query: 5979 YLYLCQFSWMLIQSVNFWY----VLVMNDEHTERRYL-LFFLLSWGLPAFVVILLIVILK 6033
YLYL F+WML++ V+ + + V+N R + F + +G+PA V +
Sbjct: 428 YLYLAAFTWMLLEGVHLFLTARNLTVVNYSSINRLMKWIMFPVGYGVPAVTVAISAASWP 487
Query: 6034 GIYHQSMSQIYGLIHGDLCFIPNVYAALFTAALVPLTCLVVVFVVFIHAYQVKPQWKAYD 6093
+Y + L G + A+F+A LV + + V +I ++
Sbjct: 488 HLYGTADRCWLHLDQGFMWSFLGPVCAIFSANLV-----LFILVFWILKRKLSSLNSEVS 542
Query: 6094 DVFRGRTNAAEIPLILYLFALISVTWLWGGLHMAYRHFWMLVLFVIFNSLQGLYVFMVYF 6153
+ R A + L++ + TW G L + M LF I NSLQG ++F+VY
Sbjct: 543 TIQNTRMLAFKATAQLFI---LGCTWCLGLLQVGPAAQVMAYLFTIINSLQGFFIFLVYC 599
Query: 6154 ILHNQM 6159
+L Q+
Sbjct: 600 LLSQQV 605
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 80.5 bits (197), Expect = 5e-14
Identities = 70/282 (24%), Positives = 122/282 (43%), Gaps = 35/282 (12%)
Query: 4230 EEKSFYEFQLTAVSEGG-------VLSESSSTANITVVASDSP---YGRFAFSHEQLRVS 4279
+ ++FY Q T + G ++ ++++ V +D P + F +
Sbjct: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCL 408
Query: 4280 E-AQRVNITIIRSSGDFGHVR-LWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEI 4337
E V +T++R GD + YKT G+A AG D+ G ++ + GE +K V I
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 4338 LDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEIGNI-----------SIV 4386
+DDD E E F + ++ V I+E + PP I N +
Sbjct: 469 IDDDIFEEDEHFFVRLSNVR---------IEEEQPEEGMPPAIFNSLPLPRAVLASPCVA 519
Query: 4387 RIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASPG 4446
+ I+ +D+A GI F+ V E +G++ + V+R G G V F + +A G
Sbjct: 520 TVTILDDDHA-GIFTFE--CDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
Query: 4447 GVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4488
G D+ + F++ + + I + I+D+ E E +E I L
Sbjct: 577 GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 71.6 bits (174), Expect = 2e-11
Identities = 53/190 (27%), Positives = 86/190 (45%), Gaps = 19/190 (10%)
Query: 3827 DNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFST 3886
D A DY E +++K + V I+ DD+ E +E F V ++ V +
Sbjct: 437 DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 3887 GQP-----SVRRPGMEIAEIMIEE----NDDPRGIFMFHVTRGAGEVITAYEVPPPLNVL 3937
G P S+ P +A + +DD GIF F V + V+
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECD--------TIHVSESIGVM 548
Query: 3938 QVPVVRLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEF 3995
+V V+R +G+ G V V ++ +A G EDF+ ++G LEF + + I + I+D+ E+
Sbjct: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEY 608
Query: 3996 ELTETFNISL 4005
E E F I+L
Sbjct: 609 ERQENFFIAL 618
Score = 65.9 bits (159), Expect = 1e-09
Identities = 59/193 (30%), Positives = 86/193 (44%), Gaps = 24/193 (12%)
Query: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISASL 2554
G A AG+DYE T +++ G+ +V I+ DD E DE F + L V +
Sbjct: 438 GSANAGADYE-FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 2555 KNQPTI-----------GQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQPQ 2603
P I P ++TV I L+ D G+F + + SE +EV+
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTFECDTIHVSESIGVMEVK---- 551
Query: 2604 TLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTILDD 2662
+ RT G+ G V V +R V GTA G DF L F ET KT+ + I+D+
Sbjct: 552 ------VLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
Query: 2663 SEPEDDESIIVSL 2675
E E E+ ++L
Sbjct: 606 EEYERQENFFIAL 618
Score = 62.8 bits (151), Expect = 1e-08
Identities = 56/221 (25%), Positives = 91/221 (41%), Gaps = 28/221 (12%)
Query: 1997 ITLSIIRLKGLMGKVL-VSYATLDDMEKPPYFPPNLARATQGRDYIPASGFALFGANQSE 2055
+ L+++R G M K + V Y T D A G DY G + +++
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTED------------GSANAGADYEFTEGTVVLKPGETQ 461
Query: 2056 ATIAISILDDDEPERSESVFIELLNSTL----------VAKVQSRSIPNSPRLGPKVETI 2105
++ I+DDD E E F+ L N + A S +P + P V T+
Sbjct: 462 KEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATV 521
Query: 2106 AQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPITAI-AG 2164
I +DD G + V+E+ + V RT GA V V F+ V TA G
Sbjct: 522 T----ILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGG 577
Query: 2165 EDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQL 2205
ED+ ++ ET K + + ++++ E +E+F + L
Sbjct: 578 EDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 61.2 bits (147), Expect = 3e-08
Identities = 55/227 (24%), Positives = 89/227 (39%), Gaps = 31/227 (13%)
Query: 2969 FEVNETHGSLTLVAQRSREPLGHVSLFVY-AQNLEAQVGLDYIFTPMILHFADGERYKNV 3027
++ E G++ L R + Y ++ A G DY FT + GE K
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEF 464
Query: 3028 NIMILDDDIPEGDEKFQLILTN--------------------PSPGLELGKNTIALIIVL 3067
++ I+DDDI E DE F + L+N P P L +A + +L
Sbjct: 465 SVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL 524
Query: 3068 ANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSS 3127
+DD G+ +F E ++V ES+ V+ + G GTV V F E +
Sbjct: 525 -DDDHAGIFTF---------ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 3128 NESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
+D + G + + K +++ + + E E E F L P
Sbjct: 575 GGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 60.1 bits (144), Expect = 7e-08
Identities = 59/210 (28%), Positives = 83/210 (39%), Gaps = 29/210 (13%)
Query: 51 IRLIIERIGEPANVTAIVSLYGEDAG-----DFFDTYAAAFIPAGETNRTVYIAVCDDDL 105
+ L + R G + T V ED D+ T + GET + + + DDD+
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Query: 106 PEPDETFIFHLTLQK------------------PSANVKLGWPRTVTVTILSNDNAFGII 147
E DE F L+ + P L P TVTIL +D+A GI
Sbjct: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIF 532
Query: 148 SFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNPPDEDLSPVKGNIT 206
+F +I VSE G M + ++R G G V+V F VEG ED G +
Sbjct: 533 TFE-CDTIHVSESIG---VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELE 588
Query: 207 FPPGRATVIYNLTVLDDEVPENDEIFLIQL 236
F + ++D+E E E F I L
Sbjct: 589 FKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 58.2 bits (139), Expect = 3e-07
Identities = 57/224 (25%), Positives = 100/224 (44%), Gaps = 20/224 (8%)
Query: 1734 EEDGEIRLLVIRAQGLLGRVT-AEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792
E G + L V+R G + + +++T +A + DY+ GT+ +PGE K + I
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDG-DMEFFLPTIHKRASLGVASQIL 1851
D+ I E ++ F V L N+ R++ +G F RA L
Sbjct: 469 IDDDIFEEDEHFFVRLSNV--------RIEEEQPEEGMPPAIFNSLPLPRAVLASPCVAT 520
Query: 1852 VTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPD 1910
VTI DHA G+F F +++ VS + + + V+R G V + + ++
Sbjct: 521 VTILDDDHA-GIFTFECDTIHVS-----ESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 1911 G---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSV 1951
G D T G + F+ +T I V+I+ +E+ E + F +++
Sbjct: 575 GGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 57.8 bits (138), Expect = 3e-07
Identities = 58/221 (26%), Positives = 97/221 (43%), Gaps = 43/221 (19%)
Query: 1885 VTLNVIRHHGTLSPVTLHWNIDSDPDG------DLAFTSGNITFEIGQTSANITVEILPD 1938
V L V+R G +S T++ + ++ DG D FT G + + G+T +V I+ D
Sbjct: 414 VLLTVVRKGGDMSK-TMYVDYKTE-DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
Query: 1939 EDPELDKAFSVSV---------------------LSVSSGSLGAHINATLTVLASDDPYG 1977
+ E D+ F V + L + L + AT+T+L DD G
Sbjct: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAG 530
Query: 1978 IFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQG 2037
IF F + + V E+ + + ++R G G V+V + T++ K G
Sbjct: 531 IFTF--ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK-----------GGG 577
Query: 2038 RDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIEL 2078
D+ G F +++ TI + I+D++E ER E+ FI L
Sbjct: 578 EDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 56.6 bits (135), Expect = 8e-07
Identities = 59/209 (28%), Positives = 92/209 (44%), Gaps = 27/209 (12%)
Query: 2131 ENHVGPIINVTRTGGAFADVS-VKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYV 2189
EN ++ V R GG + V +K +A AG DY VVL GET K + +
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 2190 INDIYPELEESFLVQLMN---------ETTGGARLGA--LTEAVI-------IIEASDDP 2231
I+D E +E F V+L N E A + L AV+ + DD
Sbjct: 469 IDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH 528
Query: 2232 YGLFGFQITKLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVV 2288
G+F F+ + V E S+ V + ++R SG G V V + T+ G G D
Sbjct: 529 AGIFTFECDTIHVSE----SIGVMEVKVLRTSGARGTVIVPF-RTVEGTAKGGGEDFEDT 583
Query: 2289 SGNVTFAPGETIQTLLLEVLADDVPEIEE 2317
G + F ET++T+ ++++ ++ E +E
Sbjct: 584 YGELEFKNDETVKTIRVKIVDEEEYERQE 612
Score = 56.2 bits (134), Expect = 1e-06
Identities = 65/242 (26%), Positives = 95/242 (39%), Gaps = 32/242 (13%)
Query: 1577 FTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITF 1636
F C + E + V R G D Y + E DG D+ GT+
Sbjct: 399 FFDPCSYQCLENCGAVLLTVVRKGG--DMSKTMYVDYKTE-DGSANAGADYEFTEGTVVL 455
Query: 1637 LPWQRSEVLNIYVLDDDIPELNEYFRVTLVSA-----IPGDGK----LGSTPTSGASIDP 1687
P + + ++ ++DDDI E +E+F V L + P +G S P A +
Sbjct: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
Query: 1688 EKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQ 1747
T +TI DH G+ F I V E G + + V+R
Sbjct: 516 PCVAT-VTILDDDHA-GIFTFECDT-----------------IHVSESIGVMEVKVLRTS 556
Query: 1748 GLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKV 1806
G G V FRTV TA ED+++ G LEF+ E K I + I D E +++F +
Sbjct: 557 GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFI 616
Query: 1807 EL 1808
L
Sbjct: 617 AL 618
Score = 55.5 bits (132), Expect = 2e-06
Identities = 48/184 (26%), Positives = 89/184 (48%), Gaps = 22/184 (11%)
Query: 4200 EFAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVS------EGGV------ 4247
++ T G + ++ ++ + ++DDI EE + +L+ V E G+
Sbjct: 445 DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFN 504
Query: 4248 -------LSESSSTANITVVASDSPYGRFAFSHEQLRVSEAQRV-NITIIRSSGDFGHVR 4299
+ S A +T++ D G F F + + VSE+ V + ++R+SG G V
Sbjct: 505 SLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVSESIGVMEVKVLRTSGARGTVI 563
Query: 4300 LWYKTMSGTAEAG-LDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVEL 4358
+ ++T+ GTA+ G DF GEL F+ E K++ V+I+D++ E E F + + + +
Sbjct: 564 VPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKW 623
Query: 4359 QGRG 4362
RG
Sbjct: 624 MERG 627
Score = 52.4 bits (124), Expect = 1e-05
Identities = 51/210 (24%), Positives = 89/210 (42%), Gaps = 15/210 (7%)
Query: 2856 GAINVTYTTVPGMLS----LKNQTVGNLAEPEVDFVPIIGFLILEEGETAAAINITILED 2911
GA+ +T G +S + +T A D+ G ++L+ GET ++ I++D
Sbjct: 412 GAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
Query: 2912 DVPELEEYFLVNLTYV---------GLTMAASTSFP-PRLDSEGLTAQVIIDANDGARGV 2961
D+ E +E+F V L+ V G+ A S P PR + +D G+
Sbjct: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGI 531
Query: 2962 IEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQNLEAQVGLDYIFTPMILHFAD 3020
++ V+E+ G + + R+ G V + F + G D+ T L F +
Sbjct: 532 FTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKN 591
Query: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
E K + + I+D++ E E F + L P
Sbjct: 592 DETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 52.0 bits (123), Expect = 2e-05
Identities = 57/205 (27%), Positives = 90/205 (43%), Gaps = 26/205 (12%)
Query: 1024 VLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPE 1083
V + G + T V Y T+DG A A D+ E T++ + G Q+ S+ + +D I E
Sbjct: 419 VRKGGDMSKTMYVDYKTEDGSANA-GADYEFTE--GTVVLKPGETQKEFSVGIIDDDIFE 475
Query: 1084 TDEPFYIILLNSTGDTVVYQYG--------------------VATVIIEANDDPNGIFSL 1123
DE F++ L N + + G VATV I +DD GIF+
Sbjct: 476 EDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTF 534
Query: 1124 EPIDKAVEEG-KTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGE 1182
E V E +LR G G+V V ++ + +A G++F +T G + F + E
Sbjct: 535 ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEG-TAKGGGEDFEDTYGELEFKNDE 593
Query: 1183 EAKPIILHAFPDKIPEFNEFYFLKL 1207
K I + ++ E E +F+ L
Sbjct: 594 TVKTIRVKIVDEEEYERQENFFIAL 618
Score = 50.8 bits (120), Expect = 4e-05
Identities = 46/180 (25%), Positives = 80/180 (44%), Gaps = 30/180 (16%)
Query: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKN-------PKGGAEIGIN 3637
+D+ + G ++ +PGE + +V I+DD + E++E F V+L N P+ G I
Sbjct: 444 ADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIF 503
Query: 3638 DSV-------------TITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGT 3684
+S+ T+TIL +D A GI F ++++ E ++ + V R G
Sbjct: 504 NSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVS----ESIGVMEVKVLRTSGA 558
Query: 3685 YGRI-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTL 3739
G + T+ A G D T G + F + + TI + I+ + E E + L
Sbjct: 559 RGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 48.9 bits (115), Expect = 2e-04
Identities = 51/206 (24%), Positives = 90/206 (43%), Gaps = 23/206 (11%)
Query: 2606 VELMIHRTGGSLGQVA-VEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664
V L + R GG + + V+++ G+A G D+ + GET+K + I+DD
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Query: 2665 PEDDESIIVSL-------VYTEGG-----------SRILPSSDTVRVNILANDNVAGIVS 2706
E+DE V L E G R + +S V + +D+ AGI +
Sbjct: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFT 533
Query: 2707 FQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLE---LNFANFSGQLFFPEG 2763
F+ + V G +++ V+RT RG V V ++ + + +F + G+L F
Sbjct: 534 FECDTIHVSESIG-VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
Query: 2764 SLNTTLFVHLLDDNIPEEKEVYQVIL 2789
T+ V ++D+ E +E + + L
Sbjct: 593 ETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 47.0 bits (110), Expect = 6e-04
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 12/151 (7%)
Query: 5018 EDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEIT 5077
E+ + L V R G S + V Y+T GSA D+E + G + + +T+ +F +
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTE-GTVVLKPGETQKEFSVG 467
Query: 5078 IINDQLSEIEEFFYINLTSVEIRGLQK--------FDVNWSPRLNL-DFSVAVITILDND 5128
II+D + E +E F++ L++V I Q F+ PR L VA +TILD D
Sbjct: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILD-D 526
Query: 5129 DLAGMDISFPETTVAVAVDTTLIPVETESTT 5159
D AG+ +F T+ V+ ++ V+ T+
Sbjct: 527 DHAGI-FTFECDTIHVSESIGVMEVKVLRTS 556
Score = 44.7 bits (104), Expect = 0.003
Identities = 41/138 (29%), Positives = 60/138 (43%), Gaps = 27/138 (19%)
Query: 5200 AVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSIT 5258
AV P VATVT H G F+ +++ E + EV + RT G G V +
Sbjct: 511 AVLASPCVATVTILDDDHAGIFTFECDTIHVSESI-----GVMEVKVLRTSGARGTVIV- 564
Query: 5259 VKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILD 5318
PFR + G T EDFE+ L F + E + + V+I+D
Sbjct: 565 ----------------PFRTVEG----TAKGGGEDFEDTYGELEFKNDETVKTIRVKIVD 604
Query: 5319 DDEPEGQEFFYVFLTNPQ 5336
++E E QE F++ L P+
Sbjct: 605 EEEYERQENFFIALGEPK 622
Score = 43.9 bits (102), Expect = 0.005
Identities = 58/250 (23%), Positives = 101/250 (40%), Gaps = 37/250 (14%)
Query: 3927 AYEVPPPLNVLQVPVVRLAGSFG-AVNVYWKASPDSAGL-EDFKPSHGILEFADKQVTAM 3984
+Y+ + + VVR G + V +K SA D++ + G + +
Sbjct: 404 SYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKE 463
Query: 3985 IEITIIDDAEFELTETFNISLISVA--------------------GGGRLGDDVVVTVVI 4024
+ IIDD FE E F + L +V L V TV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 4025 PQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEW-TIDEKAK-- 4081
+D G+F FE T+ + ES+ + + V+R+ G +GTV + + T++ AK
Sbjct: 524 LDDDHA-GIFTFECDTIHVSESI------GVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
Query: 4082 -HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKGSASII 4140
+ G L F E+ KTI + + + E F I L +E +G ++++
Sbjct: 577 GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWME----RGISALL 632
Query: 4141 IRGDKRASGE 4150
+ D++ + E
Sbjct: 633 LSPDRKLTME 642
Score = 43.5 bits (101), Expect = 0.007
Identities = 64/261 (24%), Positives = 104/261 (39%), Gaps = 45/261 (17%)
Query: 4402 FDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVT-ADFISQSSSASPGGVDYILHGSTVTFQ 4460
FDP +++ E+ G +++ VVR G D+ ++ SA+ G DY TV +
Sbjct: 400 FDP--CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN-AGADYEFTEGTVVLK 456
Query: 4461 HGQNLSFINISIIDDNESEFEEPIEILLTGA--------------------TGGAVLGRH 4500
G+ ++ IIDD+ E +E + L+ AVL
Sbjct: 457 PGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASP 516
Query: 4501 LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPN 4560
V+ + I D G+ F +I S ++ + + RT G G + V + TV
Sbjct: 517 CVATVTILDDDHA-GIFTF---ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGT 572
Query: 4561 SQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAK 4620
++ D D L + + + V+TI + I EE E +E F I L GE K
Sbjct: 573 AKGG----GEDFEDTYGELEF--KNDETVKTIRVKIVDEEEYERQENFFIAL----GEPK 622
Query: 4621 LDSR-------AKDVTLTIQE 4634
R + D LT++E
Sbjct: 623 WMERGISALLLSPDRKLTMEE 643
Score = 42.4 bits (98), Expect = 0.015
Identities = 53/213 (24%), Positives = 87/213 (40%), Gaps = 34/213 (15%)
Query: 793 SVELHIIRSRGSLVK-QFLHYRVEPRDSN---EFYGNTGVLEFKPGEREIVITLLARLDG 848
+V L ++R G + K ++ Y+ E +N ++ G + KPGE + ++ D
Sbjct: 413 AVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDD 472
Query: 849 IPELDEHYWVVLSSHGERESK-------------------LGSATIVNITILKNDDPHGI 889
I E DEH++V LS+ E + L S + +TIL +DD GI
Sbjct: 473 IFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGI 531
Query: 890 IEFVSDGLIVMINESKGDAIYSAVYDVVRNRGNFGDVSVSW----VVSPDFTQDVFPVQG 945
F D + V ++I V+R G G V V + + +D G
Sbjct: 532 FTFECDTIHV------SESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYG 585
Query: 946 TVVFGDQEFSKNITIYSLPDEIPEEMEEFTVIL 978
+ F + E K I + + +E E E F + L
Sbjct: 586 ELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 41.2 bits (95), Expect = 0.033
Identities = 53/214 (24%), Positives = 86/214 (40%), Gaps = 39/214 (18%)
Query: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558
A +D G + + GET K F + DD+ E +E F ++L +V RI EE
Sbjct: 442 AGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNV----RIEEEQPEEG 497
Query: 1559 -------------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERT 1599
A +TI D+A G+F F I ++E + V RT
Sbjct: 498 MPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTI-HVSESIGVMEVKVLRT 555
Query: 1600 RGALDYVHV-FYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELN 1658
GA V V F T+ G +DF + G + F + + + + ++D++ E
Sbjct: 556 SGARGTVIVPFRTVEGTAKGG----GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQ 611
Query: 1659 EYFRVTLVSAIPGDGKLGSTPTSGASIDPEKETT 1692
E F + L G+ K S + P+++ T
Sbjct: 612 ENFFIAL-----GEPKWMERGISALLLSPDRKLT 640
Score = 40.0 bits (92), Expect = 0.073
Identities = 20/72 (27%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 169 LTLIREKGTYGMVM-VTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPE 227
LT++R+ G M V ++ E G D +G + PG +++ ++DD++ E
Sbjct: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFE 475
Query: 228 NDEIFLIQLKSV 239
DE F ++L +V
Sbjct: 476 EDEHFFVRLSNV 487
Score = 39.3 bits (90), Expect = 0.13
Identities = 56/252 (22%), Positives = 91/252 (36%), Gaps = 46/252 (18%)
Query: 260 DSPVRFLQSIYLVP------EEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNST 313
D P F+ ++ P E +++ VVR G + Y + Y G++
Sbjct: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVR----KGGDMSKTMY---VDYKTEDGSAN 441
Query: 314 AHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGD--- 370
A A TVV P + I+DD I E E F + L ++ +
Sbjct: 442 AGADYEFT------EGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPE 495
Query: 371 ---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYE 415
AVL SP V VTI +D G+ +F T+ + E
Sbjct: 496 EGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFEC----DTIHVSES--IGVM 548
Query: 416 EITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDD 475
E+ V+R G G V + + D + G L F + + TI + +VD++
Sbjct: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGG--GEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
Query: 476 LPEEAEAYLLQI 487
E E + + +
Sbjct: 607 EYERQENFFIAL 618
Score = 38.9 bits (89), Expect = 0.16
Identities = 55/236 (23%), Positives = 95/236 (40%), Gaps = 46/236 (19%)
Query: 664 EPEDFAAEVVYIPLH---------------RDGTDGQATVYWSLKPSGFNSKAVTPDDIG 708
EPEDF ++V + P R G D T+Y K ++ A D
Sbjct: 390 EPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGA--DYE 447
Query: 709 PFNGSVLFLSGQSDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSG-----YTSRD 763
G+V+ G++ ++ I DDI E +E + L V +E + + G + S
Sbjct: 448 FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLP 507
Query: 764 L------------IILENDDPGGVFEFSPASRGPYVIKEGESV---ELHIIR---SRGSL 805
L + + +DD G+F F + I ES+ E+ ++R +RG++
Sbjct: 508 LPRAVLASPCVATVTILDDDHAGIFTFECDT-----IHVSESIGVMEVKVLRTSGARGTV 562
Query: 806 VKQFLHYRVEPRDSNEFYGNT-GVLEFKPGEREIVITLLARLDGIPELDEHYWVVL 860
+ F + E + +T G LEFK E I + + E E++++ L
Sbjct: 563 IVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 37.4 bits (85), Expect = 0.48
Identities = 31/93 (33%), Positives = 49/93 (52%), Gaps = 5/93 (5%)
Query: 5003 GVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPL-EDFEPVQNG 5061
G+F F + I VSE ++ + V R G +I V ++T G+AK EDFE G
Sbjct: 530 GIFTFECDT--IHVSESIGVMEVKVLRTSGARGTVI-VPFRTVEGTAKGGGEDFEDTY-G 585
Query: 5062 ELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5094
EL F+ +T + I++++ E +E F+I L
Sbjct: 586 ELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 35.8 bits (81), Expect = 1.4
Identities = 21/57 (36%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEEKDDTG 5349
D+E T++ GE +++ SV I+DDD E E F+V L+N +I EE+ + G
Sbjct: 445 DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSN----VRIEEEQPEEG 497
Score = 35.4 bits (80), Expect = 1.8
Identities = 52/233 (22%), Positives = 94/233 (40%), Gaps = 31/233 (13%)
Query: 4646 PETLSKKTYSEPLALE-----GPLLITFFVRRVKGTFGEIMV--YWELSSEFDITEDFLS 4698
PE K + +P + + G +L+T V R G + M Y + D+
Sbjct: 391 PEDFISKVFFDPCSYQCLENCGAVLLT--VVRKGGDMSKTMYVDYKTEDGSANAGADYEF 448
Query: 4699 TSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGGAE-------------LDL 4745
T G + GE++ F V ++ D++ E +E + ++L +V E L L
Sbjct: 449 TEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPL 508
Query: 4746 EKSITWFSVYA-----NDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG 4800
+++ A +DD G+F D +I + ++ I +++ + R +G G V V
Sbjct: 509 PRAVLASPCVATVTILDDDHAGIFTFECD--TIHVSES-IGVMEVKVLRTSGARGTVIVP 565
Query: 4801 LR-ISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQL 4852
R + K E+ +L K+ T K V I ++ NF + L
Sbjct: 566 FRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 34.3 bits (77), Expect = 4.0
Identities = 18/44 (40%), Positives = 26/44 (59%)
Query: 3586 DFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPK 3629
DF + GEL F+ E TI V I+D+ E++E+F + L PK
Sbjct: 579 DFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPK 622
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 80.5 bits (197), Expect = 5e-14
Identities = 70/282 (24%), Positives = 122/282 (43%), Gaps = 35/282 (12%)
Query: 4230 EEKSFYEFQLTAVSEGG-------VLSESSSTANITVVASDSP---YGRFAFSHEQLRVS 4279
+ ++FY Q T + G ++ ++++ V +D P + F +
Sbjct: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCL 408
Query: 4280 E-AQRVNITIIRSSGDFGHVR-LWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEI 4337
E V +T++R GD + YKT G+A AG D+ G ++ + GE +K V I
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 4338 LDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEIGNI-----------SIV 4386
+DDD E E F + ++ V I+E + PP I N +
Sbjct: 469 IDDDIFEEDEHFFVRLSNVR---------IEEEQPEEGMPPAIFNSLPLPRAVLASPCVA 519
Query: 4387 RIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASPG 4446
+ I+ +D+A GI F+ V E +G++ + V+R G G V F + +A G
Sbjct: 520 TVTILDDDHA-GIFTFE--CDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
Query: 4447 GVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4488
G D+ + F++ + + I + I+D+ E E +E I L
Sbjct: 577 GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 71.6 bits (174), Expect = 2e-11
Identities = 53/190 (27%), Positives = 86/190 (45%), Gaps = 19/190 (10%)
Query: 3827 DNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFST 3886
D A DY E +++K + V I+ DD+ E +E F V ++ V +
Sbjct: 437 DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 3887 GQP-----SVRRPGMEIAEIMIEE----NDDPRGIFMFHVTRGAGEVITAYEVPPPLNVL 3937
G P S+ P +A + +DD GIF F V + V+
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECD--------TIHVSESIGVM 548
Query: 3938 QVPVVRLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEF 3995
+V V+R +G+ G V V ++ +A G EDF+ ++G LEF + + I + I+D+ E+
Sbjct: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEY 608
Query: 3996 ELTETFNISL 4005
E E F I+L
Sbjct: 609 ERQENFFIAL 618
Score = 65.9 bits (159), Expect = 1e-09
Identities = 59/193 (30%), Positives = 86/193 (44%), Gaps = 24/193 (12%)
Query: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISASL 2554
G A AG+DYE T +++ G+ +V I+ DD E DE F + L V +
Sbjct: 438 GSANAGADYE-FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 2555 KNQPTI-----------GQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQPQ 2603
P I P ++TV I L+ D G+F + + SE +EV+
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTFECDTIHVSESIGVMEVK---- 551
Query: 2604 TLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTILDD 2662
+ RT G+ G V V +R V GTA G DF L F ET KT+ + I+D+
Sbjct: 552 ------VLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
Query: 2663 SEPEDDESIIVSL 2675
E E E+ ++L
Sbjct: 606 EEYERQENFFIAL 618
Score = 62.8 bits (151), Expect = 1e-08
Identities = 56/221 (25%), Positives = 91/221 (41%), Gaps = 28/221 (12%)
Query: 1997 ITLSIIRLKGLMGKVL-VSYATLDDMEKPPYFPPNLARATQGRDYIPASGFALFGANQSE 2055
+ L+++R G M K + V Y T D A G DY G + +++
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTED------------GSANAGADYEFTEGTVVLKPGETQ 461
Query: 2056 ATIAISILDDDEPERSESVFIELLNSTL----------VAKVQSRSIPNSPRLGPKVETI 2105
++ I+DDD E E F+ L N + A S +P + P V T+
Sbjct: 462 KEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATV 521
Query: 2106 AQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPITAI-AG 2164
I +DD G + V+E+ + V RT GA V V F+ V TA G
Sbjct: 522 T----ILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGG 577
Query: 2165 EDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQL 2205
ED+ ++ ET K + + ++++ E +E+F + L
Sbjct: 578 EDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 61.2 bits (147), Expect = 3e-08
Identities = 55/227 (24%), Positives = 89/227 (39%), Gaps = 31/227 (13%)
Query: 2969 FEVNETHGSLTLVAQRSREPLGHVSLFVY-AQNLEAQVGLDYIFTPMILHFADGERYKNV 3027
++ E G++ L R + Y ++ A G DY FT + GE K
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEF 464
Query: 3028 NIMILDDDIPEGDEKFQLILTN--------------------PSPGLELGKNTIALIIVL 3067
++ I+DDDI E DE F + L+N P P L +A + +L
Sbjct: 465 SVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL 524
Query: 3068 ANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSS 3127
+DD G+ +F E ++V ES+ V+ + G GTV V F E +
Sbjct: 525 -DDDHAGIFTF---------ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 3128 NESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
+D + G + + K +++ + + E E E F L P
Sbjct: 575 GGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 60.5 bits (145), Expect = 5e-08
Identities = 64/226 (28%), Positives = 89/226 (39%), Gaps = 32/226 (14%)
Query: 51 IRLIIERIGEPANVTAIVSLYGEDAG-----DFFDTYAAAFIPAGETNRTVYIAVCDDDL 105
+ L + R G + T V ED D+ T + GET + + + DDD+
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Query: 106 PEPDETFIFHLTLQK------------------PSANVKLGWPRTVTVTILSNDNAFGII 147
E DE F L+ + P L P TVTIL +D+A GI
Sbjct: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIF 532
Query: 148 SFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNPPDEDLSPVKGNIT 206
+F +I VSE G M + ++R G G V+V F VEG ED G +
Sbjct: 533 TFE-CDTIHVSESIG---VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELE 588
Query: 207 FPPGRATVIYNLTVLDDEVPENDEIFLIQL---KSVEGGAEINTSR 249
F + ++D+E E E F I L K +E G T R
Sbjct: 589 FKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISDVTDR 634
Score = 58.2 bits (139), Expect = 3e-07
Identities = 57/224 (25%), Positives = 100/224 (44%), Gaps = 20/224 (8%)
Query: 1734 EEDGEIRLLVIRAQGLLGRVT-AEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792
E G + L V+R G + + +++T +A + DY+ GT+ +PGE K + I
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDG-DMEFFLPTIHKRASLGVASQIL 1851
D+ I E ++ F V L N+ R++ +G F RA L
Sbjct: 469 IDDDIFEEDEHFFVRLSNV--------RIEEEQPEEGMPPAIFNSLPLPRAVLASPCVAT 520
Query: 1852 VTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPD 1910
VTI DHA G+F F +++ VS + + + V+R G V + + ++
Sbjct: 521 VTILDDDHA-GIFTFECDTIHVS-----ESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 1911 G---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSV 1951
G D T G + F+ +T I V+I+ +E+ E + F +++
Sbjct: 575 GGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 57.8 bits (138), Expect = 3e-07
Identities = 58/221 (26%), Positives = 97/221 (43%), Gaps = 43/221 (19%)
Query: 1885 VTLNVIRHHGTLSPVTLHWNIDSDPDG------DLAFTSGNITFEIGQTSANITVEILPD 1938
V L V+R G +S T++ + ++ DG D FT G + + G+T +V I+ D
Sbjct: 414 VLLTVVRKGGDMSK-TMYVDYKTE-DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
Query: 1939 EDPELDKAFSVSV---------------------LSVSSGSLGAHINATLTVLASDDPYG 1977
+ E D+ F V + L + L + AT+T+L DD G
Sbjct: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAG 530
Query: 1978 IFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQG 2037
IF F + + V E+ + + ++R G G V+V + T++ K G
Sbjct: 531 IFTF--ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK-----------GGG 577
Query: 2038 RDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIEL 2078
D+ G F +++ TI + I+D++E ER E+ FI L
Sbjct: 578 EDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 56.6 bits (135), Expect = 8e-07
Identities = 59/209 (28%), Positives = 92/209 (44%), Gaps = 27/209 (12%)
Query: 2131 ENHVGPIINVTRTGGAFADVS-VKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYV 2189
EN ++ V R GG + V +K +A AG DY VVL GET K + +
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 2190 INDIYPELEESFLVQLMN---------ETTGGARLGA--LTEAVI-------IIEASDDP 2231
I+D E +E F V+L N E A + L AV+ + DD
Sbjct: 469 IDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH 528
Query: 2232 YGLFGFQITKLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVV 2288
G+F F+ + V E S+ V + ++R SG G V V + T+ G G D
Sbjct: 529 AGIFTFECDTIHVSE----SIGVMEVKVLRTSGARGTVIVPF-RTVEGTAKGGGEDFEDT 583
Query: 2289 SGNVTFAPGETIQTLLLEVLADDVPEIEE 2317
G + F ET++T+ ++++ ++ E +E
Sbjct: 584 YGELEFKNDETVKTIRVKIVDEEEYERQE 612
Score = 56.6 bits (135), Expect = 8e-07
Identities = 69/295 (23%), Positives = 134/295 (45%), Gaps = 45/295 (15%)
Query: 4200 EFAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVS------EGGV------ 4247
++ T G + ++ ++ + ++DDI EE + +L+ V E G+
Sbjct: 445 DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFN 504
Query: 4248 -------LSESSSTANITVVASDSPYGRFAFSHEQLRVSEAQRV-NITIIRSSGDFGHVR 4299
+ S A +T++ D G F F + + VSE+ V + ++R+SG G V
Sbjct: 505 SLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVSESIGVMEVKVLRTSGARGTVI 563
Query: 4300 LWYKTMSGTAEAG-LDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVEL 4358
+ ++T+ GTA+ G DF GEL F+ E K++ V+I+D++ E E F + + + +
Sbjct: 564 VPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKW 623
Query: 4359 QGRGY-DFTIQENGLQIDQPPEIGNISIVRIIIMKNDNAEGIIE--FDPKYTAFEVEEDV 4415
RG D T ++ ++ ++ I + + ++ ++ E IIE ++ K T ++ +
Sbjct: 624 MERGISDVTDRKLTMEEEEAKRIAEMG--KPVLGEHPKLEVIIEESYEFKTTVDKLIKKT 681
Query: 4416 GLIMIPVVRLHGTYGY---------VTA----DFISQSSSASPGGVDYILHGSTV 4457
L ++ GT+ + V+A D P DY++H TV
Sbjct: 682 NLALVV-----GTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTV 731
Score = 56.2 bits (134), Expect = 1e-06
Identities = 65/242 (26%), Positives = 95/242 (39%), Gaps = 32/242 (13%)
Query: 1577 FTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITF 1636
F C + E + V R G D Y + E DG D+ GT+
Sbjct: 399 FFDPCSYQCLENCGAVLLTVVRKGG--DMSKTMYVDYKTE-DGSANAGADYEFTEGTVVL 455
Query: 1637 LPWQRSEVLNIYVLDDDIPELNEYFRVTLVSA-----IPGDGK----LGSTPTSGASIDP 1687
P + + ++ ++DDDI E +E+F V L + P +G S P A +
Sbjct: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
Query: 1688 EKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQ 1747
T +TI DH G+ F I V E G + + V+R
Sbjct: 516 PCVAT-VTILDDDHA-GIFTFECDT-----------------IHVSESIGVMEVKVLRTS 556
Query: 1748 GLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKV 1806
G G V FRTV TA ED+++ G LEF+ E K I + I D E +++F +
Sbjct: 557 GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFI 616
Query: 1807 EL 1808
L
Sbjct: 617 AL 618
Score = 52.4 bits (124), Expect = 1e-05
Identities = 51/210 (24%), Positives = 89/210 (42%), Gaps = 15/210 (7%)
Query: 2856 GAINVTYTTVPGMLS----LKNQTVGNLAEPEVDFVPIIGFLILEEGETAAAINITILED 2911
GA+ +T G +S + +T A D+ G ++L+ GET ++ I++D
Sbjct: 412 GAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
Query: 2912 DVPELEEYFLVNLTYV---------GLTMAASTSFP-PRLDSEGLTAQVIIDANDGARGV 2961
D+ E +E+F V L+ V G+ A S P PR + +D G+
Sbjct: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGI 531
Query: 2962 IEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQNLEAQVGLDYIFTPMILHFAD 3020
++ V+E+ G + + R+ G V + F + G D+ T L F +
Sbjct: 532 FTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKN 591
Query: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
E K + + I+D++ E E F + L P
Sbjct: 592 DETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 52.0 bits (123), Expect = 2e-05
Identities = 57/205 (27%), Positives = 90/205 (43%), Gaps = 26/205 (12%)
Query: 1024 VLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPE 1083
V + G + T V Y T+DG A A D+ E T++ + G Q+ S+ + +D I E
Sbjct: 419 VRKGGDMSKTMYVDYKTEDGSANA-GADYEFTE--GTVVLKPGETQKEFSVGIIDDDIFE 475
Query: 1084 TDEPFYIILLNSTGDTVVYQYG--------------------VATVIIEANDDPNGIFSL 1123
DE F++ L N + + G VATV I +DD GIF+
Sbjct: 476 EDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTF 534
Query: 1124 EPIDKAVEEG-KTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGE 1182
E V E +LR G G+V V ++ + +A G++F +T G + F + E
Sbjct: 535 ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEG-TAKGGGEDFEDTYGELEFKNDE 593
Query: 1183 EAKPIILHAFPDKIPEFNEFYFLKL 1207
K I + ++ E E +F+ L
Sbjct: 594 TVKTIRVKIVDEEEYERQENFFIAL 618
Score = 52.0 bits (123), Expect = 2e-05
Identities = 50/208 (24%), Positives = 94/208 (45%), Gaps = 33/208 (15%)
Query: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKN-------PKGGAEIGIN 3637
+D+ + G ++ +PGE + +V I+DD + E++E F V+L N P+ G I
Sbjct: 444 ADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIF 503
Query: 3638 DSV-------------TITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGT 3684
+S+ T+TIL +D A GI F ++++ E ++ + V R G
Sbjct: 504 NSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVS----ESIGVMEVKVLRTSGA 558
Query: 3685 YGRI-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTL 3739
G + T+ A G D T G + F + + TI + I+ + E E + L
Sbjct: 559 RGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Query: 3740 --TRITTEGVED-SYKGATIDQDRSKSV 3764
+ G+ D + + T++++ +K +
Sbjct: 619 GEPKWMERGISDVTDRKLTMEEEEAKRI 646
Score = 48.9 bits (115), Expect = 2e-04
Identities = 51/206 (24%), Positives = 90/206 (43%), Gaps = 23/206 (11%)
Query: 2606 VELMIHRTGGSLGQVA-VEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664
V L + R GG + + V+++ G+A G D+ + GET+K + I+DD
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Query: 2665 PEDDESIIVSL-------VYTEGG-----------SRILPSSDTVRVNILANDNVAGIVS 2706
E+DE V L E G R + +S V + +D+ AGI +
Sbjct: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFT 533
Query: 2707 FQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLE---LNFANFSGQLFFPEG 2763
F+ + V G +++ V+RT RG V V ++ + + +F + G+L F
Sbjct: 534 FECDTIHVSESIG-VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
Query: 2764 SLNTTLFVHLLDDNIPEEKEVYQVIL 2789
T+ V ++D+ E +E + + L
Sbjct: 593 ETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 47.0 bits (110), Expect = 6e-04
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 12/151 (7%)
Query: 5018 EDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEIT 5077
E+ + L V R G S + V Y+T GSA D+E + G + + +T+ +F +
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTE-GTVVLKPGETQKEFSVG 467
Query: 5078 IINDQLSEIEEFFYINLTSVEIRGLQK--------FDVNWSPRLNL-DFSVAVITILDND 5128
II+D + E +E F++ L++V I Q F+ PR L VA +TILD D
Sbjct: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILD-D 526
Query: 5129 DLAGMDISFPETTVAVAVDTTLIPVETESTT 5159
D AG+ +F T+ V+ ++ V+ T+
Sbjct: 527 DHAGI-FTFECDTIHVSESIGVMEVKVLRTS 556
Score = 46.2 bits (108), Expect = 0.001
Identities = 62/254 (24%), Positives = 102/254 (40%), Gaps = 34/254 (13%)
Query: 4402 FDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVT-ADFISQSSSASPGGVDYILHGSTVTFQ 4460
FDP +++ E+ G +++ VVR G D+ ++ SA+ G DY TV +
Sbjct: 400 FDP--CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN-AGADYEFTEGTVVLK 456
Query: 4461 HGQNLSFINISIIDDNESEFEEPIEILLTGA--------------------TGGAVLGRH 4500
G+ ++ IIDD+ E +E + L+ AVL
Sbjct: 457 PGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASP 516
Query: 4501 LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPN 4560
V+ + I D G+ F +I S ++ + + RT G G + V + TV
Sbjct: 517 CVATVTILDDDHA-GIFTF---ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGT 572
Query: 4561 SQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAK 4620
++ D D L + + + V+TI + I EE E +E F I L K +
Sbjct: 573 AKGG----GEDFEDTYGELEF--KNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMER 626
Query: 4621 LDSRAKDVTLTIQE 4634
S D LT++E
Sbjct: 627 GISDVTDRKLTMEE 640
Score = 44.7 bits (104), Expect = 0.003
Identities = 41/138 (29%), Positives = 60/138 (43%), Gaps = 27/138 (19%)
Query: 5200 AVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSIT 5258
AV P VATVT H G F+ +++ E + EV + RT G G V +
Sbjct: 511 AVLASPCVATVTILDDDHAGIFTFECDTIHVSESI-----GVMEVKVLRTSGARGTVIV- 564
Query: 5259 VKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILD 5318
PFR + G T EDFE+ L F + E + + V+I+D
Sbjct: 565 ----------------PFRTVEG----TAKGGGEDFEDTYGELEFKNDETVKTIRVKIVD 604
Query: 5319 DDEPEGQEFFYVFLTNPQ 5336
++E E QE F++ L P+
Sbjct: 605 EEEYERQENFFIALGEPK 622
Score = 42.7 bits (99), Expect = 0.011
Identities = 54/222 (24%), Positives = 87/222 (39%), Gaps = 33/222 (14%)
Query: 3927 AYEVPPPLNVLQVPVVRLAGSFG-AVNVYWKASPDSAGL-EDFKPSHGILEFADKQVTAM 3984
+Y+ + + VVR G + V +K SA D++ + G + +
Sbjct: 404 SYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKE 463
Query: 3985 IEITIIDDAEFELTETFNISLISVA--------------------GGGRLGDDVVVTVVI 4024
+ IIDD FE E F + L +V L V TV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 4025 PQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEW-TIDEKAK-- 4081
+D G+F FE T+ + ES+ + + V+R+ G +GTV + + T++ AK
Sbjct: 524 LDDDHA-GIFTFECDTIHVSESI------GVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
Query: 4082 -HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQL 4122
+ G L F E+ KTI + + + E F I L
Sbjct: 577 GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 40.0 bits (92), Expect = 0.073
Identities = 58/256 (22%), Positives = 101/256 (39%), Gaps = 46/256 (17%)
Query: 664 EPEDFAAEVVYIPLH---------------RDGTDGQATVYWSLKPSGFNSKAVTPDDIG 708
EPEDF ++V + P R G D T+Y K ++ A D
Sbjct: 390 EPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGA--DYE 447
Query: 709 PFNGSVLFLSGQSDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSG-----YTSRD 763
G+V+ G++ ++ I DDI E +E + L V +E + + G + S
Sbjct: 448 FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLP 507
Query: 764 L------------IILENDDPGGVFEFSPASRGPYVIKEGESV---ELHIIR---SRGSL 805
L + + +DD G+F F + I ES+ E+ ++R +RG++
Sbjct: 508 LPRAVLASPCVATVTILDDDHAGIFTFECDT-----IHVSESIGVMEVKVLRTSGARGTV 562
Query: 806 VKQFLHYRVEPRDSNEFYGNT-GVLEFKPGEREIVITLLARLDGIPELDEHYWVVLSSHG 864
+ F + E + +T G LEFK E I + + E E++++ L
Sbjct: 563 IVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPK 622
Query: 865 ERESKLGSATIVNITI 880
E + T +T+
Sbjct: 623 WMERGISDVTDRKLTM 638
Score = 39.3 bits (90), Expect = 0.13
Identities = 56/252 (22%), Positives = 91/252 (36%), Gaps = 46/252 (18%)
Query: 260 DSPVRFLQSIYLVP------EEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNST 313
D P F+ ++ P E +++ VVR G + Y + Y G++
Sbjct: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVR----KGGDMSKTMY---VDYKTEDGSAN 441
Query: 314 AHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGD--- 370
A A TVV P + I+DD I E E F + L ++ +
Sbjct: 442 AGADYEFT------EGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPE 495
Query: 371 ---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYE 415
AVL SP V VTI +D G+ +F T+ + E
Sbjct: 496 EGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFEC----DTIHVSES--IGVM 548
Query: 416 EITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDD 475
E+ V+R G G V + + D + G L F + + TI + +VD++
Sbjct: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGG--GEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
Query: 476 LPEEAEAYLLQI 487
E E + + +
Sbjct: 607 EYERQENFFIAL 618
Score = 39.3 bits (90), Expect = 0.13
Identities = 48/187 (25%), Positives = 76/187 (40%), Gaps = 34/187 (18%)
Query: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558
A +D G + + GET K F + DD+ E +E F ++L +V RI EE
Sbjct: 442 AGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNV----RIEEEQPEEG 497
Query: 1559 -------------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERT 1599
A +TI D+A G+F F I ++E + V RT
Sbjct: 498 MPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTI-HVSESIGVMEVKVLRT 555
Query: 1600 RGALDYVHV-FYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELN 1658
GA V V F T+ G +DF + G + F + + + + ++D++ E
Sbjct: 556 SGARGTVIVPFRTVEGTAKGG----GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQ 611
Query: 1659 EYFRVTL 1665
E F + L
Sbjct: 612 ENFFIAL 618
Score = 37.4 bits (85), Expect = 0.48
Identities = 31/93 (33%), Positives = 49/93 (52%), Gaps = 5/93 (5%)
Query: 5003 GVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPL-EDFEPVQNG 5061
G+F F + I VSE ++ + V R G +I V ++T G+AK EDFE G
Sbjct: 530 GIFTFECDT--IHVSESIGVMEVKVLRTSGARGTVI-VPFRTVEGTAKGGGEDFEDTY-G 585
Query: 5062 ELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5094
EL F+ +T + I++++ E +E F+I L
Sbjct: 586 ELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 35.8 bits (81), Expect = 1.4
Identities = 21/57 (36%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEEKDDTG 5349
D+E T++ GE +++ SV I+DDD E E F+V L+N +I EE+ + G
Sbjct: 445 DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSN----VRIEEEQPEEG 497
Score = 35.4 bits (80), Expect = 1.8
Identities = 52/233 (22%), Positives = 94/233 (40%), Gaps = 31/233 (13%)
Query: 4646 PETLSKKTYSEPLALE-----GPLLITFFVRRVKGTFGEIMV--YWELSSEFDITEDFLS 4698
PE K + +P + + G +L+T V R G + M Y + D+
Sbjct: 391 PEDFISKVFFDPCSYQCLENCGAVLLT--VVRKGGDMSKTMYVDYKTEDGSANAGADYEF 448
Query: 4699 TSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGGAE-------------LDL 4745
T G + GE++ F V ++ D++ E +E + ++L +V E L L
Sbjct: 449 TEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPL 508
Query: 4746 EKSITWFSVYA-----NDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG 4800
+++ A +DD G+F D +I + ++ I +++ + R +G G V V
Sbjct: 509 PRAVLASPCVATVTILDDDHAGIFTFECD--TIHVSES-IGVMEVKVLRTSGARGTVIVP 565
Query: 4801 LR-ISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQL 4852
R + K E+ +L K+ T K V I ++ NF + L
Sbjct: 566 FRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 80.5 bits (197), Expect = 5e-14
Identities = 70/282 (24%), Positives = 122/282 (43%), Gaps = 35/282 (12%)
Query: 4230 EEKSFYEFQLTAVSEGG-------VLSESSSTANITVVASDSP---YGRFAFSHEQLRVS 4279
+ ++FY Q T + G ++ ++++ V +D P + F +
Sbjct: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCL 408
Query: 4280 E-AQRVNITIIRSSGDFGHVR-LWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEI 4337
E V +T++R GD + YKT G+A AG D+ G ++ + GE +K V I
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 4338 LDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEIGNI-----------SIV 4386
+DDD E E F + ++ V I+E + PP I N +
Sbjct: 469 IDDDIFEEDEHFFVRLSNVR---------IEEEQPEEGMPPAIFNSLPLPRAVLASPCVA 519
Query: 4387 RIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASPG 4446
+ I+ +D+A GI F+ V E +G++ + V+R G G V F + +A G
Sbjct: 520 TVTILDDDHA-GIFTFE--CDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
Query: 4447 GVDYILHGSTVTFQHGQNLSFINISIIDDNESEFEEPIEILL 4488
G D+ + F++ + + I + I+D+ E E +E I L
Sbjct: 577 GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 71.6 bits (174), Expect = 2e-11
Identities = 53/190 (27%), Positives = 86/190 (45%), Gaps = 19/190 (10%)
Query: 3827 DNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFST 3886
D A DY E +++K + V I+ DD+ E +E F V ++ V +
Sbjct: 437 DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 3887 GQP-----SVRRPGMEIAEIMIEE----NDDPRGIFMFHVTRGAGEVITAYEVPPPLNVL 3937
G P S+ P +A + +DD GIF F V + V+
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECD--------TIHVSESIGVM 548
Query: 3938 QVPVVRLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEF 3995
+V V+R +G+ G V V ++ +A G EDF+ ++G LEF + + I + I+D+ E+
Sbjct: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEY 608
Query: 3996 ELTETFNISL 4005
E E F I+L
Sbjct: 609 ERQENFFIAL 618
Score = 65.9 bits (159), Expect = 1e-09
Identities = 59/193 (30%), Positives = 86/193 (44%), Gaps = 24/193 (12%)
Query: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISASL 2554
G A AG+DYE T +++ G+ +V I+ DD E DE F + L V +
Sbjct: 438 GSANAGADYE-FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 2555 KNQPTI-----------GQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQPQ 2603
P I P ++TV I L+ D G+F + + SE +EV+
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTFECDTIHVSESIGVMEVK---- 551
Query: 2604 TLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTILDD 2662
+ RT G+ G V V +R V GTA G DF L F ET KT+ + I+D+
Sbjct: 552 ------VLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDE 605
Query: 2663 SEPEDDESIIVSL 2675
E E E+ ++L
Sbjct: 606 EEYERQENFFIAL 618
Score = 62.8 bits (151), Expect = 1e-08
Identities = 56/221 (25%), Positives = 91/221 (41%), Gaps = 28/221 (12%)
Query: 1997 ITLSIIRLKGLMGKVL-VSYATLDDMEKPPYFPPNLARATQGRDYIPASGFALFGANQSE 2055
+ L+++R G M K + V Y T D A G DY G + +++
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTED------------GSANAGADYEFTEGTVVLKPGETQ 461
Query: 2056 ATIAISILDDDEPERSESVFIELLNSTL----------VAKVQSRSIPNSPRLGPKVETI 2105
++ I+DDD E E F+ L N + A S +P + P V T+
Sbjct: 462 KEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATV 521
Query: 2106 AQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPITAI-AG 2164
I +DD G + V+E+ + V RT GA V V F+ V TA G
Sbjct: 522 T----ILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGG 577
Query: 2165 EDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQL 2205
ED+ ++ ET K + + ++++ E +E+F + L
Sbjct: 578 EDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 61.2 bits (147), Expect = 3e-08
Identities = 55/227 (24%), Positives = 89/227 (39%), Gaps = 31/227 (13%)
Query: 2969 FEVNETHGSLTLVAQRSREPLGHVSLFVY-AQNLEAQVGLDYIFTPMILHFADGERYKNV 3027
++ E G++ L R + Y ++ A G DY FT + GE K
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEF 464
Query: 3028 NIMILDDDIPEGDEKFQLILTN--------------------PSPGLELGKNTIALIIVL 3067
++ I+DDDI E DE F + L+N P P L +A + +L
Sbjct: 465 SVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL 524
Query: 3068 ANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSS 3127
+DD G+ +F E ++V ES+ V+ + G GTV V F E +
Sbjct: 525 -DDDHAGIFTF---------ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 3128 NESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
+D + G + + K +++ + + E E E F L P
Sbjct: 575 GGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 60.1 bits (144), Expect = 7e-08
Identities = 59/210 (28%), Positives = 83/210 (39%), Gaps = 29/210 (13%)
Query: 51 IRLIIERIGEPANVTAIVSLYGEDAG-----DFFDTYAAAFIPAGETNRTVYIAVCDDDL 105
+ L + R G + T V ED D+ T + GET + + + DDD+
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Query: 106 PEPDETFIFHLTLQK------------------PSANVKLGWPRTVTVTILSNDNAFGII 147
E DE F L+ + P L P TVTIL +D+A GI
Sbjct: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIF 532
Query: 148 SFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNPPDEDLSPVKGNIT 206
+F +I VSE G M + ++R G G V+V F VEG ED G +
Sbjct: 533 TFE-CDTIHVSESIG---VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELE 588
Query: 207 FPPGRATVIYNLTVLDDEVPENDEIFLIQL 236
F + ++D+E E E F I L
Sbjct: 589 FKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 58.2 bits (139), Expect = 3e-07
Identities = 57/224 (25%), Positives = 100/224 (44%), Gaps = 20/224 (8%)
Query: 1734 EEDGEIRLLVIRAQGLLGRVT-AEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792
E G + L V+R G + + +++T +A + DY+ GT+ +PGE K + I
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDG-DMEFFLPTIHKRASLGVASQIL 1851
D+ I E ++ F V L N+ R++ +G F RA L
Sbjct: 469 IDDDIFEEDEHFFVRLSNV--------RIEEEQPEEGMPPAIFNSLPLPRAVLASPCVAT 520
Query: 1852 VTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPD 1910
VTI DHA G+F F +++ VS + + + V+R G V + + ++
Sbjct: 521 VTILDDDHA-GIFTFECDTIHVS-----ESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 1911 G---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSV 1951
G D T G + F+ +T I V+I+ +E+ E + F +++
Sbjct: 575 GGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 57.8 bits (138), Expect = 3e-07
Identities = 58/221 (26%), Positives = 97/221 (43%), Gaps = 43/221 (19%)
Query: 1885 VTLNVIRHHGTLSPVTLHWNIDSDPDG------DLAFTSGNITFEIGQTSANITVEILPD 1938
V L V+R G +S T++ + ++ DG D FT G + + G+T +V I+ D
Sbjct: 414 VLLTVVRKGGDMSK-TMYVDYKTE-DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
Query: 1939 EDPELDKAFSVSV---------------------LSVSSGSLGAHINATLTVLASDDPYG 1977
+ E D+ F V + L + L + AT+T+L DD G
Sbjct: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAG 530
Query: 1978 IFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQG 2037
IF F + + V E+ + + ++R G G V+V + T++ K G
Sbjct: 531 IFTF--ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK-----------GGG 577
Query: 2038 RDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIEL 2078
D+ G F +++ TI + I+D++E ER E+ FI L
Sbjct: 578 EDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 56.6 bits (135), Expect = 8e-07
Identities = 59/209 (28%), Positives = 92/209 (44%), Gaps = 27/209 (12%)
Query: 2131 ENHVGPIINVTRTGGAFADVS-VKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYV 2189
EN ++ V R GG + V +K +A AG DY VVL GET K + +
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 2190 INDIYPELEESFLVQLMN---------ETTGGARLGA--LTEAVI-------IIEASDDP 2231
I+D E +E F V+L N E A + L AV+ + DD
Sbjct: 469 IDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH 528
Query: 2232 YGLFGFQITKLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVV 2288
G+F F+ + V E S+ V + ++R SG G V V + T+ G G D
Sbjct: 529 AGIFTFECDTIHVSE----SIGVMEVKVLRTSGARGTVIVPF-RTVEGTAKGGGEDFEDT 583
Query: 2289 SGNVTFAPGETIQTLLLEVLADDVPEIEE 2317
G + F ET++T+ ++++ ++ E +E
Sbjct: 584 YGELEFKNDETVKTIRVKIVDEEEYERQE 612
Score = 56.2 bits (134), Expect = 1e-06
Identities = 65/242 (26%), Positives = 95/242 (39%), Gaps = 32/242 (13%)
Query: 1577 FTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITF 1636
F C + E + V R G D Y + E DG D+ GT+
Sbjct: 399 FFDPCSYQCLENCGAVLLTVVRKGG--DMSKTMYVDYKTE-DGSANAGADYEFTEGTVVL 455
Query: 1637 LPWQRSEVLNIYVLDDDIPELNEYFRVTLVSA-----IPGDGK----LGSTPTSGASIDP 1687
P + + ++ ++DDDI E +E+F V L + P +G S P A +
Sbjct: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
Query: 1688 EKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQ 1747
T +TI DH G+ F I V E G + + V+R
Sbjct: 516 PCVAT-VTILDDDHA-GIFTFECDT-----------------IHVSESIGVMEVKVLRTS 556
Query: 1748 GLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKV 1806
G G V FRTV TA ED+++ G LEF+ E K I + I D E +++F +
Sbjct: 557 GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFI 616
Query: 1807 EL 1808
L
Sbjct: 617 AL 618
Score = 55.5 bits (132), Expect = 2e-06
Identities = 48/184 (26%), Positives = 89/184 (48%), Gaps = 22/184 (11%)
Query: 4200 EFAETSGKLTMRDEQSAVIVVIQALNDDIPEEKSFYEFQLTAVS------EGGV------ 4247
++ T G + ++ ++ + ++DDI EE + +L+ V E G+
Sbjct: 445 DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFN 504
Query: 4248 -------LSESSSTANITVVASDSPYGRFAFSHEQLRVSEAQRV-NITIIRSSGDFGHVR 4299
+ S A +T++ D G F F + + VSE+ V + ++R+SG G V
Sbjct: 505 SLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVSESIGVMEVKVLRTSGARGTVI 563
Query: 4300 LWYKTMSGTAEAG-LDFVPAAGELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVEL 4358
+ ++T+ GTA+ G DF GEL F+ E K++ V+I+D++ E E F + + + +
Sbjct: 564 VPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKW 623
Query: 4359 QGRG 4362
RG
Sbjct: 624 MERG 627
Score = 52.4 bits (124), Expect = 1e-05
Identities = 51/210 (24%), Positives = 89/210 (42%), Gaps = 15/210 (7%)
Query: 2856 GAINVTYTTVPGMLS----LKNQTVGNLAEPEVDFVPIIGFLILEEGETAAAINITILED 2911
GA+ +T G +S + +T A D+ G ++L+ GET ++ I++D
Sbjct: 412 GAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
Query: 2912 DVPELEEYFLVNLTYV---------GLTMAASTSFP-PRLDSEGLTAQVIIDANDGARGV 2961
D+ E +E+F V L+ V G+ A S P PR + +D G+
Sbjct: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGI 531
Query: 2962 IEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQNLEAQVGLDYIFTPMILHFAD 3020
++ V+E+ G + + R+ G V + F + G D+ T L F +
Sbjct: 532 FTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKN 591
Query: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
E K + + I+D++ E E F + L P
Sbjct: 592 DETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 52.0 bits (123), Expect = 2e-05
Identities = 57/205 (27%), Positives = 90/205 (43%), Gaps = 26/205 (12%)
Query: 1024 VLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPE 1083
V + G + T V Y T+DG A A D+ E T++ + G Q+ S+ + +D I E
Sbjct: 419 VRKGGDMSKTMYVDYKTEDGSANA-GADYEFTE--GTVVLKPGETQKEFSVGIIDDDIFE 475
Query: 1084 TDEPFYIILLNSTGDTVVYQYG--------------------VATVIIEANDDPNGIFSL 1123
DE F++ L N + + G VATV I +DD GIF+
Sbjct: 476 EDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTF 534
Query: 1124 EPIDKAVEEG-KTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGE 1182
E V E +LR G G+V V ++ + +A G++F +T G + F + E
Sbjct: 535 ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEG-TAKGGGEDFEDTYGELEFKNDE 593
Query: 1183 EAKPIILHAFPDKIPEFNEFYFLKL 1207
K I + ++ E E +F+ L
Sbjct: 594 TVKTIRVKIVDEEEYERQENFFIAL 618
Score = 50.8 bits (120), Expect = 4e-05
Identities = 46/180 (25%), Positives = 80/180 (44%), Gaps = 30/180 (16%)
Query: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKN-------PKGGAEIGIN 3637
+D+ + G ++ +PGE + +V I+DD + E++E F V+L N P+ G I
Sbjct: 444 ADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIF 503
Query: 3638 DSV-------------TITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGT 3684
+S+ T+TIL +D A GI F ++++ E ++ + V R G
Sbjct: 504 NSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVS----ESIGVMEVKVLRTSGA 558
Query: 3685 YGRI-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTL 3739
G + T+ A G D T G + F + + TI + I+ + E E + L
Sbjct: 559 RGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 48.9 bits (115), Expect = 2e-04
Identities = 51/206 (24%), Positives = 90/206 (43%), Gaps = 23/206 (11%)
Query: 2606 VELMIHRTGGSLGQVA-VEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664
V L + R GG + + V+++ G+A G D+ + GET+K + I+DD
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Query: 2665 PEDDESIIVSL-------VYTEGG-----------SRILPSSDTVRVNILANDNVAGIVS 2706
E+DE V L E G R + +S V + +D+ AGI +
Sbjct: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFT 533
Query: 2707 FQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLE---LNFANFSGQLFFPEG 2763
F+ + V G +++ V+RT RG V V ++ + + +F + G+L F
Sbjct: 534 FECDTIHVSESIG-VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
Query: 2764 SLNTTLFVHLLDDNIPEEKEVYQVIL 2789
T+ V ++D+ E +E + + L
Sbjct: 593 ETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 47.0 bits (110), Expect = 6e-04
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 12/151 (7%)
Query: 5018 EDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEIT 5077
E+ + L V R G S + V Y+T GSA D+E + G + + +T+ +F +
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTE-GTVVLKPGETQKEFSVG 467
Query: 5078 IINDQLSEIEEFFYINLTSVEIRGLQK--------FDVNWSPRLNL-DFSVAVITILDND 5128
II+D + E +E F++ L++V I Q F+ PR L VA +TILD D
Sbjct: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILD-D 526
Query: 5129 DLAGMDISFPETTVAVAVDTTLIPVETESTT 5159
D AG+ +F T+ V+ ++ V+ T+
Sbjct: 527 DHAGI-FTFECDTIHVSESIGVMEVKVLRTS 556
Score = 44.7 bits (104), Expect = 0.003
Identities = 41/138 (29%), Positives = 60/138 (43%), Gaps = 27/138 (19%)
Query: 5200 AVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSIT 5258
AV P VATVT H G F+ +++ E + EV + RT G G V +
Sbjct: 511 AVLASPCVATVTILDDDHAGIFTFECDTIHVSESI-----GVMEVKVLRTSGARGTVIV- 564
Query: 5259 VKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILD 5318
PFR + G T EDFE+ L F + E + + V+I+D
Sbjct: 565 ----------------PFRTVEG----TAKGGGEDFEDTYGELEFKNDETVKTIRVKIVD 604
Query: 5319 DDEPEGQEFFYVFLTNPQ 5336
++E E QE F++ L P+
Sbjct: 605 EEEYERQENFFIALGEPK 622
Score = 43.9 bits (102), Expect = 0.005
Identities = 76/317 (23%), Positives = 119/317 (37%), Gaps = 54/317 (17%)
Query: 4402 FDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVT-ADFISQSSSASPGGVDYILHGSTVTFQ 4460
FDP +++ E+ G +++ VVR G D+ ++ SA+ G DY TV +
Sbjct: 400 FDP--CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN-AGADYEFTEGTVVLK 456
Query: 4461 HGQNLSFINISIIDDNESEFEEPIEILLTGA--------------------TGGAVLGRH 4500
G+ ++ IIDD+ E +E + L+ AVL
Sbjct: 457 PGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASP 516
Query: 4501 LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPN 4560
V+ + I D G+ F +I S ++ + + RT G G + V + TV
Sbjct: 517 CVATVTILDDDHA-GIFTF---ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGT 572
Query: 4561 SQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKLHLVKGEAK 4620
++ D D L + + + V+TI + I EE E +E F I L GE K
Sbjct: 573 AKGG----GEDFEDTYGELEF--KNDETVKTIRVKIVDEEEYERQENFFIAL----GEPK 622
Query: 4621 LDSRAKDVTLTIQEFGDPNGVVQFAPETLSKKTYSEPLALEGPLLITFFVRRVKGTFGEI 4680
R L +P+ +K E E I + V G ++
Sbjct: 623 WMERGISALL-------------LSPDVTDRKLTMEE---EEAKRIAEMGKPVLGEHPKL 666
Query: 4681 MVYWELSSEFDITEDFL 4697
V E S EF T D L
Sbjct: 667 EVIIEESYEFKTTVDKL 683
Score = 42.7 bits (99), Expect = 0.011
Identities = 54/222 (24%), Positives = 87/222 (39%), Gaps = 33/222 (14%)
Query: 3927 AYEVPPPLNVLQVPVVRLAGSFG-AVNVYWKASPDSAGL-EDFKPSHGILEFADKQVTAM 3984
+Y+ + + VVR G + V +K SA D++ + G + +
Sbjct: 404 SYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKE 463
Query: 3985 IEITIIDDAEFELTETFNISLISVA--------------------GGGRLGDDVVVTVVI 4024
+ IIDD FE E F + L +V L V TV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 4025 PQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEW-TIDEKAK-- 4081
+D G+F FE T+ + ES+ + + V+R+ G +GTV + + T++ AK
Sbjct: 524 LDDDHA-GIFTFECDTIHVSESI------GVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
Query: 4082 -HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQL 4122
+ G L F E+ KTI + + + E F I L
Sbjct: 577 GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 42.4 bits (98), Expect = 0.015
Identities = 53/213 (24%), Positives = 87/213 (40%), Gaps = 34/213 (15%)
Query: 793 SVELHIIRSRGSLVK-QFLHYRVEPRDSN---EFYGNTGVLEFKPGEREIVITLLARLDG 848
+V L ++R G + K ++ Y+ E +N ++ G + KPGE + ++ D
Sbjct: 413 AVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDD 472
Query: 849 IPELDEHYWVVLSSHGERESK-------------------LGSATIVNITILKNDDPHGI 889
I E DEH++V LS+ E + L S + +TIL +DD GI
Sbjct: 473 IFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGI 531
Query: 890 IEFVSDGLIVMINESKGDAIYSAVYDVVRNRGNFGDVSVSW----VVSPDFTQDVFPVQG 945
F D + V ++I V+R G G V V + + +D G
Sbjct: 532 FTFECDTIHV------SESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYG 585
Query: 946 TVVFGDQEFSKNITIYSLPDEIPEEMEEFTVIL 978
+ F + E K I + + +E E E F + L
Sbjct: 586 ELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 40.0 bits (92), Expect = 0.073
Identities = 20/72 (27%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 169 LTLIREKGTYGMVM-VTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPE 227
LT++R+ G M V ++ E G D +G + PG +++ ++DD++ E
Sbjct: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFE 475
Query: 228 NDEIFLIQLKSV 239
DE F ++L +V
Sbjct: 476 EDEHFFVRLSNV 487
Score = 40.0 bits (92), Expect = 0.073
Identities = 53/222 (23%), Positives = 88/222 (39%), Gaps = 39/222 (17%)
Query: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558
A +D G + + GET K F + DD+ E +E F ++L +V RI EE
Sbjct: 442 AGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNV----RIEEEQPEEG 497
Query: 1559 -------------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERT 1599
A +TI D+A G+F F I ++E + V RT
Sbjct: 498 MPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTI-HVSESIGVMEVKVLRT 555
Query: 1600 RGALDYVHV-FYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELN 1658
GA V V F T+ G +DF + G + F + + + + ++D++ E
Sbjct: 556 SGARGTVIVPFRTVEGTAKGG----GEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQ 611
Query: 1659 EYFRVTLVSAIPGDGKLGSTPTSGASIDPEKETTDITIKASD 1700
E F + L G+ K S + P+ +T++ +
Sbjct: 612 ENFFIAL-----GEPKWMERGISALLLSPDVTDRKLTMEEEE 648
Score = 39.3 bits (90), Expect = 0.13
Identities = 56/252 (22%), Positives = 91/252 (36%), Gaps = 46/252 (18%)
Query: 260 DSPVRFLQSIYLVP------EEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNST 313
D P F+ ++ P E +++ VVR G + Y + Y G++
Sbjct: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVR----KGGDMSKTMY---VDYKTEDGSAN 441
Query: 314 AHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGD--- 370
A A TVV P + I+DD I E E F + L ++ +
Sbjct: 442 AGADYEFT------EGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPE 495
Query: 371 ---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYE 415
AVL SP V VTI +D G+ +F T+ + E
Sbjct: 496 EGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFEC----DTIHVSES--IGVM 548
Query: 416 EITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDD 475
E+ V+R G G V + + D + G L F + + TI + +VD++
Sbjct: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGG--GEDFEDTYGELEFKNDETVKTIRVKIVDEE 606
Query: 476 LPEEAEAYLLQI 487
E E + + +
Sbjct: 607 EYERQENFFIAL 618
Score = 38.9 bits (89), Expect = 0.16
Identities = 55/236 (23%), Positives = 95/236 (40%), Gaps = 46/236 (19%)
Query: 664 EPEDFAAEVVYIPLH---------------RDGTDGQATVYWSLKPSGFNSKAVTPDDIG 708
EPEDF ++V + P R G D T+Y K ++ A D
Sbjct: 390 EPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGA--DYE 447
Query: 709 PFNGSVLFLSGQSDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSG-----YTSRD 763
G+V+ G++ ++ I DDI E +E + L V +E + + G + S
Sbjct: 448 FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLP 507
Query: 764 L------------IILENDDPGGVFEFSPASRGPYVIKEGESV---ELHIIR---SRGSL 805
L + + +DD G+F F + I ES+ E+ ++R +RG++
Sbjct: 508 LPRAVLASPCVATVTILDDDHAGIFTFECDT-----IHVSESIGVMEVKVLRTSGARGTV 562
Query: 806 VKQFLHYRVEPRDSNEFYGNT-GVLEFKPGEREIVITLLARLDGIPELDEHYWVVL 860
+ F + E + +T G LEFK E I + + E E++++ L
Sbjct: 563 IVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 37.4 bits (85), Expect = 0.48
Identities = 31/93 (33%), Positives = 49/93 (52%), Gaps = 5/93 (5%)
Query: 5003 GVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPL-EDFEPVQNG 5061
G+F F + I VSE ++ + V R G +I V ++T G+AK EDFE G
Sbjct: 530 GIFTFECDT--IHVSESIGVMEVKVLRTSGARGTVI-VPFRTVEGTAKGGGEDFEDTY-G 585
Query: 5062 ELFFQKFQTEVDFEITIINDQLSEIEEFFYINL 5094
EL F+ +T + I++++ E +E F+I L
Sbjct: 586 ELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 35.8 bits (81), Expect = 1.4
Identities = 21/57 (36%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEEKDDTG 5349
D+E T++ GE +++ SV I+DDD E E F+V L+N +I EE+ + G
Sbjct: 445 DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSN----VRIEEEQPEEG 497
Score = 35.4 bits (80), Expect = 1.8
Identities = 52/233 (22%), Positives = 94/233 (40%), Gaps = 31/233 (13%)
Query: 4646 PETLSKKTYSEPLALE-----GPLLITFFVRRVKGTFGEIMV--YWELSSEFDITEDFLS 4698
PE K + +P + + G +L+T V R G + M Y + D+
Sbjct: 391 PEDFISKVFFDPCSYQCLENCGAVLLT--VVRKGGDMSKTMYVDYKTEDGSANAGADYEF 448
Query: 4699 TSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGGAE-------------LDL 4745
T G + GE++ F V ++ D++ E +E + ++L +V E L L
Sbjct: 449 TEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPL 508
Query: 4746 EKSITWFSVYA-----NDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG 4800
+++ A +DD G+F D +I + ++ I +++ + R +G G V V
Sbjct: 509 PRAVLASPCVATVTILDDDHAGIFTFECD--TIHVSES-IGVMEVKVLRTSGARGTVIVP 565
Query: 4801 LR-ISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQL 4852
R + K E+ +L K+ T K V I ++ NF + L
Sbjct: 566 FRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIAL 618
Score = 34.3 bits (77), Expect = 4.0
Identities = 18/44 (40%), Positives = 26/44 (59%)
Query: 3586 DFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPK 3629
DF + GEL F+ E TI V I+D+ E++E+F + L PK
Sbjct: 579 DFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPK 622
>gi|24475871 G protein-coupled receptor 114 [Homo sapiens]
Length = 528
Score = 79.3 bits (194), Expect = 1e-13
Identities = 89/382 (23%), Positives = 151/382 (39%), Gaps = 47/382 (12%)
Query: 5800 YSSQQWFISGNNLPTLKNKVLSLSVK-GQSSQLLTNDNEVLYRIYAAEPRIIPQTSLCLL 5858
+S+ +F NN L N VL + G + L N + + E T C+
Sbjct: 136 FSNTHFFKDENNSSLLNNYVLGAQLSHGHVNNLRDPVNISFWHNQSLEG----YTLTCVF 191
Query: 5859 WNQAA-----ASWLSDSQFCKVVEETADYVECACSHMSVYAVYARTDNLSSYNEAFFTSG 5913
W + A W + C+ + + V C C+H++ +AV + E
Sbjct: 192 WKEGARKQPWGGWSPEG--CRTEQPSHSQVLCRCNHLTYFAVLMQLSPALVPAELLAPLT 249
Query: 5914 FICISGLCLA-------VLSHIFCARYSMFAAKLLTHMMAASLGTQILFLAS-AYASPQL 5965
+I + G ++ VL H + S ++ ++ A+ L I FL S A+A +
Sbjct: 250 YISLVGCSISIVASLITVLLHFHFRKQSDSLTRIHMNLHASVLLLNIAFLLSPAFAMSPV 309
Query: 5966 AEESCSAMAAVTHYLYLCQFSWMLIQSVNFWYVLVMNDEHTERRYLL-FFLLSWGLPAFV 6024
+C+A+AA HY L +WM I+ N + +L RRY+ +L WG PA +
Sbjct: 310 PGSACTALAAALHYALLSCLTWMAIEGFNLYLLLGRVYNIYIRRYVFKLGVLGWGAPALL 369
Query: 6025 VILLIVILKGIYHQSMSQIY-------GLIHGDLCFI--PNVYAALFT--AALVPLTCLV 6073
V+L + + +Y ++ G + +C++ P V++ L L L LV
Sbjct: 370 VLLSLSVKSSVYGPCTIPVFDSWENGTGFQNMSICWVRSPVVHSVLVMGYGGLTSLFNLV 429
Query: 6074 VVFVVFIHAYQVK-----PQWKAYDDVFRGRTNAAEIPLILYLFALISVTWLWGGLHMAY 6128
V+ +++ P +A D +L L L+ TW
Sbjct: 430 VLAWALWTLRRLRERADAPSVRACHDTV----------TVLGLTVLLGTTWALAFFSFGV 479
Query: 6129 RHFWMLVLFVIFNSLQGLYVFM 6150
L LF I NSL G ++F+
Sbjct: 480 FLLPQLFLFTILNSLYGFFLFL 501
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 78.2 bits (191), Expect = 2e-13
Identities = 68/273 (24%), Positives = 118/273 (43%), Gaps = 35/273 (12%)
Query: 4230 EEKSFYEFQLTAVSEGG-------VLSESSSTANITVVASDSP---YGRFAFSHEQLRVS 4279
+ ++FY Q T + G ++ ++++ V +D P + F +
Sbjct: 349 KSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCL 408
Query: 4280 E-AQRVNITIIRSSGDFGHVR-LWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEI 4337
E V +T++R GD + YKT G+A AG D+ G ++ + GE +K V I
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 4338 LDDDYPEGPEEFSLTITKVELQGRGYDFTIQENGLQIDQPPEIGNI-----------SIV 4386
+DDD E E F + ++ V I+E + PP I N +
Sbjct: 469 IDDDIFEEDEHFFVRLSNVR---------IEEEQPEEGMPPAIFNSLPLPRAVLASPCVA 519
Query: 4387 RIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVTADFISQSSSASPG 4446
+ I+ +D+A GI F+ V E +G++ + V+R G G V F + +A G
Sbjct: 520 TVTILDDDHA-GIFTFE--CDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
Query: 4447 GVDYILHGSTVTFQHGQNLSFINISIIDDNESE 4479
G D+ + F++ + + I+I +IDD E
Sbjct: 577 GEDFEDTYGELEFKNDETVKTIHIKVIDDEAYE 609
Score = 68.2 bits (165), Expect = 3e-10
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 19/191 (9%)
Query: 3827 DNQATENEDYVLQETIIIMKENIKEAHAEVSILPDDLPELEEGFIVTITEVNLVNSDFST 3886
D A DY E +++K + V I+ DD+ E +E F V ++ V +
Sbjct: 437 DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 3887 GQP-----SVRRPGMEIAEIMIEE----NDDPRGIFMFHVTRGAGEVITAYEVPPPLNVL 3937
G P S+ P +A + +DD GIF F V + V+
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFE--------CDTIHVSESIGVM 548
Query: 3938 QVPVVRLAGSFGAVNVYWKASPDSA--GLEDFKPSHGILEFADKQVTAMIEITIIDDAEF 3995
+V V+R +G+ G V V ++ +A G EDF+ ++G LEF + + I I +IDD +
Sbjct: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAY 608
Query: 3996 ELTETFNISLI 4006
E + + I ++
Sbjct: 609 EKNKNYFIEMM 619
Score = 64.3 bits (155), Expect = 4e-09
Identities = 58/222 (26%), Positives = 92/222 (41%), Gaps = 28/222 (12%)
Query: 1997 ITLSIIRLKGLMGKVL-VSYATLDDMEKPPYFPPNLARATQGRDYIPASGFALFGANQSE 2055
+ L+++R G M K + V Y T D A G DY G + +++
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTED------------GSANAGADYEFTEGTVVLKPGETQ 461
Query: 2056 ATIAISILDDDEPERSESVFIELLNSTLV----------AKVQSRSIPNSPRLGPKVETI 2105
++ I+DDD E E F+ L N + A S +P + P V T+
Sbjct: 462 KEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATV 521
Query: 2106 AQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVSVKFKAVPITAI-AG 2164
I +DD G + V+E+ + V RT GA V V F+ V TA G
Sbjct: 522 T----ILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGG 577
Query: 2165 EDYSIASSDVVLLEGETSKAVPIYVINDIYPELEESFLVQLM 2206
ED+ ++ ET K + I VI+D E +++ +++M
Sbjct: 578 EDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMM 619
Score = 63.5 bits (153), Expect = 6e-09
Identities = 56/194 (28%), Positives = 86/194 (44%), Gaps = 24/194 (12%)
Query: 2495 GQAVAGSDYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISASL 2554
G A AG+DYE T +++ G+ +V I+ DD E DE F + L V +
Sbjct: 438 GSANAGADYE-FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEE 496
Query: 2555 KNQPTI-----------GQPNISTVVIALNGDAFGVFVIYNISPNTSEDGLFVEVQEQPQ 2603
P I P ++TV I L+ D G+F + + SE +EV+
Sbjct: 497 GMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTFECDTIHVSESIGVMEVK---- 551
Query: 2604 TLVELMIHRTGGSLGQVAVEWRVVGGTAT-EGLDFIGAGEILTFAEGETKKTVILTILDD 2662
+ RT G+ G V V +R V GTA G DF L F ET KT+ + ++DD
Sbjct: 552 ------VLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDD 605
Query: 2663 SEPEDDESIIVSLV 2676
E +++ + ++
Sbjct: 606 EAYEKNKNYFIEMM 619
Score = 62.0 bits (149), Expect = 2e-08
Identities = 58/210 (27%), Positives = 86/210 (40%), Gaps = 29/210 (13%)
Query: 51 IRLIIERIGEPANVTAIVSLYGEDAG-----DFFDTYAAAFIPAGETNRTVYIAVCDDDL 105
+ L + R G + T V ED D+ T + GET + + + DDD+
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Query: 106 PEPDETFIFHLTLQK------------------PSANVKLGWPRTVTVTILSNDNAFGII 147
E DE F L+ + P L P TVTIL +D+A GI
Sbjct: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIF 532
Query: 148 SFNMLPSIAVSEPKGRNESMPLTLIREKGTYGMVMVTFE-VEGGPNPPDEDLSPVKGNIT 206
+F +I VSE G M + ++R G G V+V F VEG ED G +
Sbjct: 533 TFE-CDTIHVSESIG---VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELE 588
Query: 207 FPPGRATVIYNLTVLDDEVPENDEIFLIQL 236
F ++ V+DDE E ++ + I++
Sbjct: 589 FKNDETVKTIHIKVIDDEAYEKNKNYFIEM 618
Score = 59.7 bits (143), Expect = 9e-08
Identities = 65/243 (26%), Positives = 97/243 (39%), Gaps = 32/243 (13%)
Query: 1577 FTGACIPEIAEEGSTISCVVERTRGALDYVHVFYTISQIETDGINYLVDDFANASGTITF 1636
F C + E + V R G D Y + E DG D+ GT+
Sbjct: 399 FFDPCSYQCLENCGAVLLTVVRKGG--DMSKTMYVDYKTE-DGSANAGADYEFTEGTVVL 455
Query: 1637 LPWQRSEVLNIYVLDDDIPELNEYFRVTLVSA-----IPGDGK----LGSTPTSGASIDP 1687
P + + ++ ++DDDI E +E+F V L + P +G S P A +
Sbjct: 456 KPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLAS 515
Query: 1688 EKETTDITIKASDHPYGLLQFSTGLPPQPKDAMTLPASSVPHITVEEEDGEIRLLVIRAQ 1747
T +TI DH G+ F I V E G + + V+R
Sbjct: 516 PCVAT-VTILDDDHA-GIFTFECDT-----------------IHVSESIGVMEVKVLRTS 556
Query: 1748 GLLGRVTAEFRTVSLTA-FSPEDYQNVAGTLEFQPGERYKYIFINITDNSIPELEKSFKV 1806
G G V FRTV TA ED+++ G LEF+ E K I I + D+ E K++ +
Sbjct: 557 GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFI 616
Query: 1807 ELL 1809
E++
Sbjct: 617 EMM 619
Score = 59.3 bits (142), Expect = 1e-07
Identities = 61/239 (25%), Positives = 106/239 (44%), Gaps = 43/239 (17%)
Query: 1885 VTLNVIRHHGTLSPVTLHWNIDSDPDG------DLAFTSGNITFEIGQTSANITVEILPD 1938
V L V+R G +S T++ + ++ DG D FT G + + G+T +V I+ D
Sbjct: 414 VLLTVVRKGGDMSK-TMYVDYKTE-DGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
Query: 1939 EDPELDKAFSVSVLSV-------SSGSLGAHIN--------------ATLTVLASDDPYG 1977
+ E D+ F V + +V G A N AT+T+L DD G
Sbjct: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAG 530
Query: 1978 IFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARATQG 2037
IF F + V E+ + + ++R G G V+V + T++ K G
Sbjct: 531 IFTFECDT--IHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG-----------G 577
Query: 2038 RDYIPASGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRSIPNSP 2096
D+ G F +++ TI I ++DD+ E++++ FIE++ +V +++ SP
Sbjct: 578 EDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQKALLLSP 636
Score = 58.9 bits (141), Expect = 2e-07
Identities = 54/227 (23%), Positives = 88/227 (38%), Gaps = 31/227 (13%)
Query: 2969 FEVNETHGSLTLVAQRSREPLGHVSLFVY-AQNLEAQVGLDYIFTPMILHFADGERYKNV 3027
++ E G++ L R + Y ++ A G DY FT + GE K
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEF 464
Query: 3028 NIMILDDDIPEGDEKFQLILTN--------------------PSPGLELGKNTIALIIVL 3067
++ I+DDDI E DE F + L+N P P L +A + +L
Sbjct: 465 SVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL 524
Query: 3068 ANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNSS 3127
+DD G+ +F E ++V ES+ V+ + G GTV V F E +
Sbjct: 525 -DDDHAGIFTF---------ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 3128 NESKDLTPSKGYIVLEEGVRFKALQISAILDTEPEMDEYFVCTLFNP 3174
+D + G + + K + I I D E ++ + + P
Sbjct: 575 GGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
Score = 58.5 bits (140), Expect = 2e-07
Identities = 56/225 (24%), Positives = 100/225 (44%), Gaps = 20/225 (8%)
Query: 1734 EEDGEIRLLVIRAQGLLGRVT-AEFRTVSLTAFSPEDYQNVAGTLEFQPGERYKYIFINI 1792
E G + L V+R G + + +++T +A + DY+ GT+ +PGE K + I
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 1793 TDNSIPELEKSFKVELLNLEGGVAELFRVDGSGSGDG-DMEFFLPTIHKRASLGVASQIL 1851
D+ I E ++ F V L N+ R++ +G F RA L
Sbjct: 469 IDDDIFEEDEHFFVRLSNV--------RIEEEQPEEGMPPAIFNSLPLPRAVLASPCVAT 520
Query: 1852 VTIAASDHAHGVFEFSPESLFVSGTEPEDGYSTVTLNVIRHHGTLSPVTLHW-NIDSDPD 1910
VTI DHA G+F F +++ VS + + + V+R G V + + ++
Sbjct: 521 VTILDDDHA-GIFTFECDTIHVS-----ESIGVMEVKVLRTSGARGTVIVPFRTVEGTAK 574
Query: 1911 G---DLAFTSGNITFEIGQTSANITVEILPDEDPELDKAFSVSVL 1952
G D T G + F+ +T I ++++ DE E +K + + ++
Sbjct: 575 GGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMM 619
Score = 58.2 bits (139), Expect = 3e-07
Identities = 60/206 (29%), Positives = 90/206 (43%), Gaps = 27/206 (13%)
Query: 2131 ENHVGPIINVTRTGGAFADVS-VKFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYV 2189
EN ++ V R GG + V +K +A AG DY VVL GET K + +
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468
Query: 2190 INDIYPELEESFLVQLMN---------ETTGGARLGA--LTEAVI-------IIEASDDP 2231
I+D E +E F V+L N E A + L AV+ + DD
Sbjct: 469 IDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH 528
Query: 2232 YGLFGFQITKLIVEEPEFNSVKV-NLPIIRNSGTLGNVTVQWVATINGQLATG--DLRVV 2288
G+F F+ + V E S+ V + ++R SG G V V + T+ G G D
Sbjct: 529 AGIFTFECDTIHVSE----SIGVMEVKVLRTSGARGTVIVPF-RTVEGTAKGGGEDFEDT 583
Query: 2289 SGNVTFAPGETIQTLLLEVLADDVPE 2314
G + F ET++T+ ++V+ D+ E
Sbjct: 584 YGELEFKNDETVKTIHIKVIDDEAYE 609
Score = 58.2 bits (139), Expect = 3e-07
Identities = 58/206 (28%), Positives = 93/206 (45%), Gaps = 26/206 (12%)
Query: 1024 VLRNGSVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIFVNEDGIPE 1083
V + G + T V Y T+DG A A D+ E T++ + G Q+ S+ + +D I E
Sbjct: 419 VRKGGDMSKTMYVDYKTEDGSANA-GADYEFTE--GTVVLKPGETQKEFSVGIIDDDIFE 475
Query: 1084 TDEPFYIILLNSTGDTVVYQYG--------------------VATVIIEANDDPNGIFSL 1123
DE F++ L N + + G VATV I +DD GIF+
Sbjct: 476 EDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI-LDDDHAGIFTF 534
Query: 1124 EPIDKAVEEG-KTNAFWILRHRGYFGSVSVSWQLFQNDSALQPGQEFYETSGTVNFMDGE 1182
E V E +LR G G+V V ++ + +A G++F +T G + F + E
Sbjct: 535 ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEG-TAKGGGEDFEDTYGELEFKNDE 593
Query: 1183 EAKPIILHAFPDKIPEFNEFYFLKLV 1208
K I + D+ E N+ YF++++
Sbjct: 594 TVKTIHIKVIDDEAYEKNKNYFIEMM 619
Score = 52.0 bits (123), Expect = 2e-05
Identities = 49/210 (23%), Positives = 91/210 (43%), Gaps = 15/210 (7%)
Query: 2856 GAINVTYTTVPGMLS----LKNQTVGNLAEPEVDFVPIIGFLILEEGETAAAINITILED 2911
GA+ +T G +S + +T A D+ G ++L+ GET ++ I++D
Sbjct: 412 GAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDD 471
Query: 2912 DVPELEEYFLVNLTYV---------GLTMAASTSFP-PRLDSEGLTAQVIIDANDGARGV 2961
D+ E +E+F V L+ V G+ A S P PR + +D G+
Sbjct: 472 DIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGI 531
Query: 2962 IEWQQSRFEVNETHGSLTLVAQRSREPLGHVSL-FVYAQNLEAQVGLDYIFTPMILHFAD 3020
++ V+E+ G + + R+ G V + F + G D+ T L F +
Sbjct: 532 FTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKN 591
Query: 3021 GERYKNVNIMILDDDIPEGDEKFQLILTNP 3050
E K ++I ++DD+ E ++ + + + P
Sbjct: 592 DETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
Score = 50.8 bits (120), Expect = 4e-05
Identities = 44/171 (25%), Positives = 77/171 (45%), Gaps = 30/171 (17%)
Query: 3585 SDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKN-------PKGGAEIGIN 3637
+D+ + G ++ +PGE + +V I+DD + E++E F V+L N P+ G I
Sbjct: 444 ADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIF 503
Query: 3638 DSV-------------TITILSNDDAYGIVAFAQNSLYKQVEEMEQDSLVTLNVERLKGT 3684
+S+ T+TIL +D A GI F ++++ E ++ + V R G
Sbjct: 504 NSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTIHVS----ESIGVMEVKVLRTSGA 558
Query: 3685 YGRI-----TIAWEADGSISDIFPTSGVILFTEGQVLSTITLTILADNIPE 3730
G + T+ A G D T G + F + + TI + ++ D E
Sbjct: 559 RGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYE 609
Score = 50.4 bits (119), Expect = 5e-05
Identities = 50/202 (24%), Positives = 88/202 (43%), Gaps = 23/202 (11%)
Query: 2606 VELMIHRTGGSLGQVA-VEWRVVGGTATEGLDFIGAGEILTFAEGETKKTVILTILDDSE 2664
V L + R GG + + V+++ G+A G D+ + GET+K + I+DD
Sbjct: 414 VLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Query: 2665 PEDDESIIVSL-------VYTEGG-----------SRILPSSDTVRVNILANDNVAGIVS 2706
E+DE V L E G R + +S V + +D+ AGI +
Sbjct: 474 FEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFT 533
Query: 2707 FQTASRSVIGHEGEILQFHVIRTFPGRGNVTVNWKIIGQNLE---LNFANFSGQLFFPEG 2763
F+ + V G +++ V+RT RG V V ++ + + +F + G+L F
Sbjct: 534 FECDTIHVSESIG-VMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKND 592
Query: 2764 SLNTTLFVHLLDDNIPEEKEVY 2785
T+ + ++DD E+ + Y
Sbjct: 593 ETVKTIHIKVIDDEAYEKNKNY 614
Score = 49.3 bits (116), Expect = 1e-04
Identities = 58/250 (23%), Positives = 106/250 (42%), Gaps = 36/250 (14%)
Query: 3927 AYEVPPPLNVLQVPVVRLAGSFG-AVNVYWKASPDSAGL-EDFKPSHGILEFADKQVTAM 3984
+Y+ + + VVR G + V +K SA D++ + G + +
Sbjct: 404 SYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKE 463
Query: 3985 IEITIIDDAEFELTETFNISLISVA--------------------GGGRLGDDVVVTVVI 4024
+ IIDD FE E F + L +V L V TV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 4025 PQNDSPFGVFGFEEKTVMIDESLSSDDPDSYVTLTVVRSPGGKGTVRLEW-TIDEKAK-- 4081
+D G+F FE T+ + ES+ + + V+R+ G +GTV + + T++ AK
Sbjct: 524 LDDDHA-GIFTFECDTIHVSESI------GVMEVKVLRTSGARGTVIVPFRTVEGTAKGG 576
Query: 4082 -HNLSPLNGTLHFDETESQKTIVLHTLQDTVLEEDRRFTIQLISIDEVEISPVKGSASII 4140
+ G L F E+ KTI + + D E+++ + I+++ V++S K +++
Sbjct: 577 GEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVDMSFQK---ALL 633
Query: 4141 IRGDKRASGE 4150
+ D++ + E
Sbjct: 634 LSPDRKLTME 643
Score = 47.0 bits (110), Expect = 6e-04
Identities = 46/151 (30%), Positives = 75/151 (49%), Gaps = 12/151 (7%)
Query: 5018 EDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPLEDFEPVQNGELFFQKFQTEVDFEIT 5077
E+ + L V R G S + V Y+T GSA D+E + G + + +T+ +F +
Sbjct: 409 ENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTE-GTVVLKPGETQKEFSVG 467
Query: 5078 IINDQLSEIEEFFYINLTSVEIRGLQK--------FDVNWSPRLNL-DFSVAVITILDND 5128
II+D + E +E F++ L++V I Q F+ PR L VA +TILD D
Sbjct: 468 IIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILD-D 526
Query: 5129 DLAGMDISFPETTVAVAVDTTLIPVETESTT 5159
D AG+ +F T+ V+ ++ V+ T+
Sbjct: 527 DHAGI-FTFECDTIHVSESIGVMEVKVLRTS 556
Score = 43.5 bits (101), Expect = 0.007
Identities = 57/253 (22%), Positives = 94/253 (37%), Gaps = 46/253 (18%)
Query: 260 DSPVRFLQSIYLVP------EEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNST 313
D P F+ ++ P E +++ VVR G + Y + Y G++
Sbjct: 389 DEPEDFISKVFFDPCSYQCLENCGAVLLTVVR----KGGDMSKTMY---VDYKTEDGSAN 441
Query: 314 AHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGD--- 370
A A TVV P + I+DD I E E F + L ++ +
Sbjct: 442 AGADYEFT------EGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPE 495
Query: 371 ---------------AVLISPSVVQVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYE 415
AVL SP V VTI +D G+ +F T+ + E
Sbjct: 496 EGMPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFEC----DTIHVSES--IGVM 548
Query: 416 EITVVRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDD 475
E+ V+R G G V + + D + G L F + + TI + V+DD+
Sbjct: 549 EVKVLRTSGARGTVIVPFRTVEGTAKGG--GEDFEDTYGELEFKNDETVKTIHIKVIDDE 606
Query: 476 LPEEAEAYLLQIL 488
E+ + Y ++++
Sbjct: 607 AYEKNKNYFIEMM 619
Score = 42.0 bits (97), Expect = 0.019
Identities = 49/188 (26%), Positives = 79/188 (42%), Gaps = 34/188 (18%)
Query: 1503 AKSDLHPISGYLEFRQGETNKSFIISARDDNDEEGEELFILKLVSVYGGARISEEN---- 1558
A +D G + + GET K F + DD+ E +E F ++L +V RI EE
Sbjct: 442 AGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNV----RIEEEQPEEG 497
Query: 1559 -------------------TTARLTIQKSDNANGLFGFTGACIPEIAEEGSTISCVVERT 1599
A +TI D+A G+F F I ++E + V RT
Sbjct: 498 MPPAIFNSLPLPRAVLASPCVATVTILDDDHA-GIFTFECDTI-HVSESIGVMEVKVLRT 555
Query: 1600 RGALDYVHV-FYTISQIETDGINYLVDDFANASGTITFLPWQRSEVLNIYVLDDDIPELN 1658
GA V V F T+ G +DF + G + F + + ++I V+DD+ E N
Sbjct: 556 SGARGTVIVPFRTVEGTAKGG----GEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKN 611
Query: 1659 EYFRVTLV 1666
+ + + ++
Sbjct: 612 KNYFIEMM 619
Score = 41.2 bits (95), Expect = 0.033
Identities = 52/214 (24%), Positives = 89/214 (41%), Gaps = 34/214 (15%)
Query: 793 SVELHIIRSRGSLVK-QFLHYRVEPRDSN---EFYGNTGVLEFKPGEREIVITLLARLDG 848
+V L ++R G + K ++ Y+ E +N ++ G + KPGE + ++ D
Sbjct: 413 AVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDD 472
Query: 849 IPELDEHYWVVLSSHGERESK-------------------LGSATIVNITILKNDDPHGI 889
I E DEH++V LS+ E + L S + +TIL +DD GI
Sbjct: 473 IFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTIL-DDDHAGI 531
Query: 890 IEFVSDGLIVMINESKGDAIYSAVYDVVRNRGNFGDVSVSW----VVSPDFTQDVFPVQG 945
F D + V ++I V+R G G V V + + +D G
Sbjct: 532 FTFECDTIHV------SESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYG 585
Query: 946 TVVFGDQEFSKNITIYSLPDEIPEEMEEFTVILL 979
+ F + E K I I + DE E+ + + + ++
Sbjct: 586 ELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMM 619
Score = 40.4 bits (93), Expect = 0.056
Identities = 55/234 (23%), Positives = 95/234 (40%), Gaps = 46/234 (19%)
Query: 664 EPEDFAAEVVYIPLH---------------RDGTDGQATVYWSLKPSGFNSKAVTPDDIG 708
EPEDF ++V + P R G D T+Y K ++ A D
Sbjct: 390 EPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGA--DYE 447
Query: 709 PFNGSVLFLSGQSDTTINITIKGDDIPEMNETVTLSLDRVNVENQVLKSG-----YTSRD 763
G+V+ G++ ++ I DDI E +E + L V +E + + G + S
Sbjct: 448 FTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLP 507
Query: 764 L------------IILENDDPGGVFEFSPASRGPYVIKEGESV---ELHIIR---SRGSL 805
L + + +DD G+F F + I ES+ E+ ++R +RG++
Sbjct: 508 LPRAVLASPCVATVTILDDDHAGIFTFECDT-----IHVSESIGVMEVKVLRTSGARGTV 562
Query: 806 VKQFLHYRVEPRDSNEFYGNT-GVLEFKPGEREIVITLLARLDGIPELDEHYWV 858
+ F + E + +T G LEFK E I + D E +++Y++
Sbjct: 563 IVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFI 616
Score = 40.0 bits (92), Expect = 0.073
Identities = 20/72 (27%), Positives = 37/72 (51%), Gaps = 1/72 (1%)
Query: 169 LTLIREKGTYGMVM-VTFEVEGGPNPPDEDLSPVKGNITFPPGRATVIYNLTVLDDEVPE 227
LT++R+ G M V ++ E G D +G + PG +++ ++DD++ E
Sbjct: 416 LTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFE 475
Query: 228 NDEIFLIQLKSV 239
DE F ++L +V
Sbjct: 476 EDEHFFVRLSNV 487
Score = 38.1 bits (87), Expect = 0.28
Identities = 35/138 (25%), Positives = 58/138 (42%), Gaps = 27/138 (19%)
Query: 5200 AVSEKPDVATVTANVSIH-GTFSLGPSIVYIEEEMKNGTFNTAEVLIRRTGGFTGNVSIT 5258
AV P VATVT H G F+ +++ E + EV + RT G G V +
Sbjct: 511 AVLASPCVATVTILDDDHAGIFTFECDTIHVSESI-----GVMEVKVLRTSGARGTVIV- 564
Query: 5259 VKTFGERCAQMEPNALPFRGIYGISNLTWAVEEEDFEEQTLTLIFLDGERERKVSVQILD 5318
PFR + G T EDFE+ L F + E + + ++++D
Sbjct: 565 ----------------PFRTVEG----TAKGGGEDFEDTYGELEFKNDETVKTIHIKVID 604
Query: 5319 DDEPEGQEFFYVFLTNPQ 5336
D+ E + +++ + P+
Sbjct: 605 DEAYEKNKNYFIEMMGPR 622
Score = 37.4 bits (85), Expect = 0.48
Identities = 51/232 (21%), Positives = 92/232 (39%), Gaps = 34/232 (14%)
Query: 4402 FDPKYTAFEVEEDVGLIMIPVVRLHGTYGYVT-ADFISQSSSASPGGVDYILHGSTVTFQ 4460
FDP +++ E+ G +++ VVR G D+ ++ SA+ G DY TV +
Sbjct: 400 FDP--CSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSAN-AGADYEFTEGTVVLK 456
Query: 4461 HGQNLSFINISIIDDNESEFEEPIEILLTGA--------------------TGGAVLGRH 4500
G+ ++ IIDD+ E +E + L+ AVL
Sbjct: 457 PGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASP 516
Query: 4501 LVSRIIIAKSDSPFGVIRFLNQSKISIANPNSTMILSLVLERTGGLLGEIQVNWETVGPN 4560
V+ + I D G+ F +I S ++ + + RT G G + V + TV
Sbjct: 517 CVATVTILDDDHA-GIFTF---ECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGT 572
Query: 4561 SQEALLPQNRDIADPVSGLFYFGEGEGGVRTIILTIYPHEEIEVEETFIIKL 4612
++ D D L + + + V+TI + + E E + + I++
Sbjct: 573 AKGG----GEDFEDTYGELEF--KNDETVKTIHIKVIDDEAYEKNKNYFIEM 618
Score = 37.0 bits (84), Expect = 0.62
Identities = 35/114 (30%), Positives = 57/114 (50%), Gaps = 10/114 (8%)
Query: 5003 GVFQFSTSSRNIIVSEDTQMIRLHVQRLFGFHSDLIKVSYQTTAGSAKPL-EDFEPVQNG 5061
G+F F + I VSE ++ + V R G +I V ++T G+AK EDFE G
Sbjct: 530 GIFTFECDT--IHVSESIGVMEVKVLRTSGARGTVI-VPFRTVEGTAKGGGEDFEDTY-G 585
Query: 5062 ELFFQKFQTEVDFEITIINDQLSEIEEFFYINLTSVEIRGLQKFDVNWSPRLNL 5115
EL F+ +T I +I+D+ E + ++I E+ G + D+++ L L
Sbjct: 586 ELEFKNDETVKTIHIKVIDDEAYEKNKNYFI-----EMMGPRMVDMSFQKALLL 634
Score = 35.8 bits (81), Expect = 1.4
Identities = 21/57 (36%), Positives = 33/57 (57%), Gaps = 4/57 (7%)
Query: 5293 DFEEQTLTLIFLDGERERKVSVQILDDDEPEGQEFFYVFLTNPQGGAQIVEEKDDTG 5349
D+E T++ GE +++ SV I+DDD E E F+V L+N +I EE+ + G
Sbjct: 445 DYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSN----VRIEEEQPEEG 497
Score = 35.0 bits (79), Expect = 2.4
Identities = 50/243 (20%), Positives = 98/243 (40%), Gaps = 31/243 (12%)
Query: 4646 PETLSKKTYSEPLALE-----GPLLITFFVRRVKGTFGEIMV--YWELSSEFDITEDFLS 4698
PE K + +P + + G +L+T V R G + M Y + D+
Sbjct: 391 PEDFISKVFFDPCSYQCLENCGAVLLT--VVRKGGDMSKTMYVDYKTEDGSANAGADYEF 448
Query: 4699 TSGFFTIADGESEASFDVHLLPDEVPEIEEDYVIQLVSVEGGAE-------------LDL 4745
T G + GE++ F V ++ D++ E +E + ++L +V E L L
Sbjct: 449 TEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPL 508
Query: 4746 EKSITWFSVYA-----NDDPHGVFALYSDRQSILIGQNLIRSIQINITRLAGTFGDVAVG 4800
+++ A +DD G+F D +I + ++ I +++ + R +G G V V
Sbjct: 509 PRAVLASPCVATVTILDDDHAGIFTFECD--TIHVSES-IGVMEVKVLRTSGARGTVIVP 565
Query: 4801 LR-ISSDHKEQPIVTENAERQLVVKDGATYKVDVVPIKNQVFLSLGSNFTLQLVTVMLVG 4859
R + K E+ +L K+ T K + + + N+ ++++ +V
Sbjct: 566 FRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPRMVD 625
Query: 4860 GRF 4862
F
Sbjct: 626 MSF 628
Score = 33.1 bits (74), Expect = 9.0
Identities = 14/44 (31%), Positives = 26/44 (59%)
Query: 3586 DFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPK 3629
DF + GEL F+ E TI + ++DD EK +++ +++ P+
Sbjct: 579 DFEDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGPR 622
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 231,298,493
Number of Sequences: 37866
Number of extensions: 10615112
Number of successful extensions: 25537
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 88
Number of HSP's that attempted gapping in prelim test: 22634
Number of HSP's gapped (non-prelim): 1218
length of query: 6306
length of database: 18,247,518
effective HSP length: 126
effective length of query: 6180
effective length of database: 13,476,402
effective search space: 83284164360
effective search space used: 83284164360
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 74 (33.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.