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Search of human proteins with 21361454
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361454 pyrroline-5-carboxylate reductase family, member 2
[Homo sapiens]
(320 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361454 pyrroline-5-carboxylate reductase family, member 2 [... 618 e-177
gi|24797097 pyrroline-5-carboxylate reductase 1 isoform 1 [Homo ... 528 e-150
gi|24797095 pyrroline-5-carboxylate reductase 1 isoform 2 [Homo ... 500 e-142
gi|198041662 pyrroline-5-carboxylate reductase-like [Homo sapiens] 224 8e-59
gi|164698426 hypothetical protein LOC122945 isoform 1 [Homo sapi... 44 1e-04
gi|20302040 hypothetical protein LOC122945 isoform 2 [Homo sapiens] 44 1e-04
gi|109452589 family with sequence similarity 98, member B isofor... 31 1.7
gi|109452587 family with sequence similarity 98, member B isofor... 31 1.7
gi|56549653 neuro-oncological ventral antigen 1 isoform 1 [Homo ... 30 3.7
gi|6031189 neuro-oncological ventral antigen 1 isoform 3 [Homo s... 30 3.7
gi|24307999 glycerol-3-phosphate dehydrogenase 1-like [Homo sapi... 28 8.3
>gi|21361454 pyrroline-5-carboxylate reductase family, member 2
[Homo sapiens]
Length = 320
Score = 618 bits (1593), Expect = e-177
Identities = 320/320 (100%), Positives = 320/320 (100%)
Query: 1 MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV 60
MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV
Sbjct: 1 MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV 60
Query: 61 KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC 120
KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC
Sbjct: 61 KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC 120
Query: 121 MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY 180
MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY
Sbjct: 121 MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY 180
Query: 181 AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH 240
AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH
Sbjct: 181 AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH 240
Query: 241 ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL 300
ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL
Sbjct: 241 ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL 300
Query: 301 TPSSPGKLLTRSLALGGKKD 320
TPSSPGKLLTRSLALGGKKD
Sbjct: 301 TPSSPGKLLTRSLALGGKKD 320
>gi|24797097 pyrroline-5-carboxylate reductase 1 isoform 1 [Homo
sapiens]
Length = 319
Score = 528 bits (1361), Expect = e-150
Identities = 270/318 (84%), Positives = 297/318 (93%)
Query: 1 MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV 60
MSVGFIGAGQLA+ALA+GFTAAG+L+AHKI+ASSP+M+L TVSALRKMGV LT NKETV
Sbjct: 1 MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV 60
Query: 61 KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC 120
+HSDVLFLAVKPHIIPFILDEIGAD++ RHIVVSCAAGVTISS+EKKL AF+PAP+VIRC
Sbjct: 61 QHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRC 120
Query: 121 MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY 180
MTNTPVVV+EGATVYATGTHA VEDG+L+EQL+SSVGFCTEVEEDLIDAVTGLSGSGPAY
Sbjct: 121 MTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAY 180
Query: 181 AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH 240
AF ALDALADGGVKMGLPRRLA++LGAQALLGAAKMLL SEQHP QLKDNV SPGGATIH
Sbjct: 181 AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIH 240
Query: 241 ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRVKLESPTVSTL 300
ALH LESGGFRSLLINAVEASCIRTRELQSMADQE++SPAA+KKT+LD+VKL+SP + L
Sbjct: 241 ALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDKVKLDSPAGTAL 300
Query: 301 TPSSPGKLLTRSLALGGK 318
+PS KLL RSLA GK
Sbjct: 301 SPSGHTKLLPRSLAPAGK 318
>gi|24797095 pyrroline-5-carboxylate reductase 1 isoform 2 [Homo
sapiens]
Length = 316
Score = 500 bits (1288), Expect = e-142
Identities = 253/289 (87%), Positives = 277/289 (95%)
Query: 1 MSVGFIGAGQLAYALARGFTAAGILSAHKIIASSPEMNLPTVSALRKMGVNLTRSNKETV 60
MSVGFIGAGQLA+ALA+GFTAAG+L+AHKI+ASSP+M+L TVSALRKMGV LT NKETV
Sbjct: 1 MSVGFIGAGQLAFALAKGFTAAGVLAAHKIMASSPDMDLATVSALRKMGVKLTPHNKETV 60
Query: 61 KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRC 120
+HSDVLFLAVKPHIIPFILDEIGAD++ RHIVVSCAAGVTISS+EKKL AF+PAP+VIRC
Sbjct: 61 QHSDVLFLAVKPHIIPFILDEIGADIEDRHIVVSCAAGVTISSIEKKLSAFRPAPRVIRC 120
Query: 121 MTNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAY 180
MTNTPVVV+EGATVYATGTHA VEDG+L+EQL+SSVGFCTEVEEDLIDAVTGLSGSGPAY
Sbjct: 121 MTNTPVVVREGATVYATGTHAQVEDGRLMEQLLSSVGFCTEVEEDLIDAVTGLSGSGPAY 180
Query: 181 AFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIH 240
AF ALDALADGGVKMGLPRRLA++LGAQALLGAAKMLL SEQHP QLKDNV SPGGATIH
Sbjct: 181 AFTALDALADGGVKMGLPRRLAVRLGAQALLGAAKMLLHSEQHPGQLKDNVSSPGGATIH 240
Query: 241 ALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDR 289
ALH LESGGFRSLLINAVEASCIRTRELQSMADQE++SPAA+KKT+LD+
Sbjct: 241 ALHVLESGGFRSLLINAVEASCIRTRELQSMADQEQVSPAAIKKTILDK 289
>gi|198041662 pyrroline-5-carboxylate reductase-like [Homo sapiens]
Length = 286
Score = 224 bits (571), Expect = 8e-59
Identities = 124/267 (46%), Positives = 172/267 (64%), Gaps = 7/267 (2%)
Query: 3 VGFIGAGQLAYALARGFTAAGILSAHKIIASSP-EMNLPTVSALRKMGVNLTRSNKETVK 61
VGF+GAG++A A+A+G AG + A I+AS+P + NL AL G T SN+E ++
Sbjct: 23 VGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCHFQAL---GCRTTHSNQEVLQ 79
Query: 62 HSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCM 121
++ A KPH++P +L E+ V HI+VS AAGV++S++E+ L P +V+R +
Sbjct: 80 SCLLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLSTLEELL---PPNTRVLRVL 136
Query: 122 TNTPVVVQEGATVYATGTHALVEDGQLLEQLMSSVGFCTEVEEDLIDAVTGLSGSGPAYA 181
N P VVQEGA V A G H + +LL+ L+ + G C EV E +D TGLSGSG A+
Sbjct: 137 PNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVPEAYVDIHTGLSGSGVAFV 196
Query: 182 FMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDNVCSPGGATIHA 241
+ALA+G VKMG+P LA ++ AQ LLG AKMLL QHP QL+ +VC+PGG TI+
Sbjct: 197 CAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYG 256
Query: 242 LHFLESGGFRSLLINAVEASCIRTREL 268
LH LE GG R+ ++AVEA+ R +EL
Sbjct: 257 LHALEQGGLRAATMSAVEAATCRAKEL 283
>gi|164698426 hypothetical protein LOC122945 isoform 1 [Homo
sapiens]
Length = 359
Score = 44.3 bits (103), Expect = 1e-04
Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 6/101 (5%)
Query: 3 VGFIGAGQLAYALARGFTAAGILSAHKIIASS--PEMNLPTVSALRKMGVNLTRSNKETV 60
VG IG G L LA G + A + S+ PE T+ L+K+G+ N + V
Sbjct: 79 VGIIGGGHLGKQLAGTLLQLGPIPAESLRISTRRPE----TLGELQKLGIKCFYHNADLV 134
Query: 61 KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTI 101
+DV+FL P +P I EI ++ IV S A + +
Sbjct: 135 SWADVIFLCCLPSQLPNICVEIYTSLEKASIVYSFVAAIPL 175
>gi|20302040 hypothetical protein LOC122945 isoform 2 [Homo sapiens]
Length = 250
Score = 44.3 bits (103), Expect = 1e-04
Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 6/101 (5%)
Query: 3 VGFIGAGQLAYALARGFTAAGILSAHKIIASS--PEMNLPTVSALRKMGVNLTRSNKETV 60
VG IG G L LA G + A + S+ PE T+ L+K+G+ N + V
Sbjct: 79 VGIIGGGHLGKQLAGTLLQLGPIPAESLRISTRRPE----TLGELQKLGIKCFYHNADLV 134
Query: 61 KHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTI 101
+DV+FL P +P I EI ++ IV S A + +
Sbjct: 135 SWADVIFLCCLPSQLPNICVEIYTSLEKASIVYSFVAAIPL 175
>gi|109452589 family with sequence similarity 98, member B isoform 2
[Homo sapiens]
Length = 330
Score = 30.8 bits (68), Expect = 1.7
Identities = 24/89 (26%), Positives = 38/89 (42%), Gaps = 13/89 (14%)
Query: 162 VEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSE 221
+E D++D + L GP AL A+GG+ L I LG+Q
Sbjct: 12 MEGDVLDTLEALGYKGPLLEEQALTKAAEGGLSSPEFSELCIWLGSQI------------ 59
Query: 222 QHPCQLKDNVCSPGGATIHALHFLESGGF 250
+ C L++++ S G + + LE GF
Sbjct: 60 KSLCNLEESITSAGRDDLESFQ-LEISGF 87
>gi|109452587 family with sequence similarity 98, member B isoform 1
[Homo sapiens]
Length = 433
Score = 30.8 bits (68), Expect = 1.7
Identities = 24/89 (26%), Positives = 38/89 (42%), Gaps = 13/89 (14%)
Query: 162 VEEDLIDAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSE 221
+E D++D + L GP AL A+GG+ L I LG+Q
Sbjct: 12 MEGDVLDTLEALGYKGPLLEEQALTKAAEGGLSSPEFSELCIWLGSQI------------ 59
Query: 222 QHPCQLKDNVCSPGGATIHALHFLESGGF 250
+ C L++++ S G + + LE GF
Sbjct: 60 KSLCNLEESITSAGRDDLESFQ-LEISGF 87
>gi|56549653 neuro-oncological ventral antigen 1 isoform 1 [Homo
sapiens]
Length = 507
Score = 29.6 bits (65), Expect = 3.7
Identities = 36/144 (25%), Positives = 61/144 (42%), Gaps = 14/144 (9%)
Query: 171 TGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDN 230
T G + + + + A G + +G + +QL Q GA L S+ +
Sbjct: 42 TNTGEDGQYFLKVLIPSYAAGSI-IGKGGQTIVQL--QKETGATIKLSKSKDFYPGTTER 98
Query: 231 VCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRV 290
VC G T+ AL+ + GF + I + + +T + + Q ++P +K+TL
Sbjct: 99 VCLIQG-TVEALNAVH--GFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQTL---- 151
Query: 291 KLESPTVSTLTPSSPGKLLTRSLA 314
P+ T T SSP +T S A
Sbjct: 152 ----PSSPTTTKSSPSDPMTTSRA 171
>gi|6031189 neuro-oncological ventral antigen 1 isoform 3 [Homo
sapiens]
Length = 181
Score = 29.6 bits (65), Expect = 3.7
Identities = 36/144 (25%), Positives = 61/144 (42%), Gaps = 14/144 (9%)
Query: 171 TGLSGSGPAYAFMALDALADGGVKMGLPRRLAIQLGAQALLGAAKMLLDSEQHPCQLKDN 230
T G + + + + A G + +G + +QL Q GA L S+ +
Sbjct: 42 TNTGEDGQYFLKVLIPSYAAGSI-IGKGGQTIVQL--QKETGATIKLSKSKDFYPGTTER 98
Query: 231 VCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTLLDRV 290
VC G T+ AL+ + GF + I + + +T + + Q ++P +K+TL
Sbjct: 99 VCLIQG-TVEALNAVH--GFIAEKIREMPQNVAKTEPVSILQPQTTVNPDRIKQTL---- 151
Query: 291 KLESPTVSTLTPSSPGKLLTRSLA 314
P+ T T SSP +T S A
Sbjct: 152 ----PSSPTTTKSSPSDPMTTSRA 171
>gi|24307999 glycerol-3-phosphate dehydrogenase 1-like [Homo
sapiens]
Length = 351
Score = 28.5 bits (62), Expect = 8.3
Identities = 51/252 (20%), Positives = 94/252 (37%), Gaps = 40/252 (15%)
Query: 58 ETVKHSDVLFLAVKPHIIPFILDEIGADVQARHIVVSCAAGVTISSVEKKLMAFQPAPKV 117
E V+ +D+L + I I DEI V + + ++ G+ KL++ +
Sbjct: 83 EAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLIS-----DI 137
Query: 118 IRCMTNTPVVVQEGATV----------YATGTHALVEDGQLLEQLMSSVGFCTEVEEDLI 167
IR + V GA + T ++E+G L ++L+ + F V +
Sbjct: 138 IREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITV----V 193
Query: 168 DAVTGLSGSGPAYAFMALDALADGGVKMGLPRRLA-IQLGAQALLGAAKMLLDSEQHPCQ 226
D + G +A+ A G++ G + A I+LG ++ A++ +
Sbjct: 194 DDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQ----- 248
Query: 227 LKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKISPAALKKTL 286
+ FLES G L+ R R + + + L+K +
Sbjct: 249 ------------VSTATFLESCGVADLITTCYGG---RNRRVAEAFARTGKTIEELEKEM 293
Query: 287 LDRVKLESPTVS 298
L+ KL+ P S
Sbjct: 294 LNGQKLQGPQTS 305
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,284,244
Number of Sequences: 37866
Number of extensions: 467872
Number of successful extensions: 1121
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1111
Number of HSP's gapped (non-prelim): 11
length of query: 320
length of database: 18,247,518
effective HSP length: 102
effective length of query: 218
effective length of database: 14,385,186
effective search space: 3135970548
effective search space used: 3135970548
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.