Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 21359972
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21359972 kelch repeat and BTB (POZ) domain containing 7
[Homo sapiens]
(684 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo... 1393 0.0
gi|45333883 kelch repeat and BTB (POZ) domain-containing 6 [Homo... 1248 0.0
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 243 3e-64
gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Hom... 218 1e-56
gi|148664248 kelch domain containing 6 [Homo sapiens] 181 2e-45
gi|55925608 kelch-like 21 [Homo sapiens] 174 2e-43
gi|40807500 kelch-like 20 [Homo sapiens] 171 2e-42
gi|109150407 kelch-like 6 [Homo sapiens] 159 1e-38
gi|40018614 DRE1 protein [Homo sapiens] 155 9e-38
gi|166235129 kelch-like 3 [Homo sapiens] 153 6e-37
gi|40255071 kelch-like 23 [Homo sapiens] 149 6e-36
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 149 8e-36
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 147 2e-35
gi|223890235 intracisternal A particle-promoted polypeptide isof... 147 4e-35
gi|38194229 kelch-like 17 [Homo sapiens] 147 4e-35
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 144 4e-34
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 144 4e-34
gi|34101268 kelch-like 8 [Homo sapiens] 142 8e-34
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 140 5e-33
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 138 1e-32
gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Hom... 138 1e-32
gi|24308181 kelch-like 9 [Homo sapiens] 137 4e-32
gi|24432026 kelch-like [Homo sapiens] 134 2e-31
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 134 3e-31
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 134 3e-31
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 134 4e-31
gi|11056006 kelch-like 12 [Homo sapiens] 132 1e-30
gi|45643138 kelch-like 13 [Homo sapiens] 129 7e-30
gi|128485503 kelch-like 30 [Homo sapiens] 129 9e-30
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 123 6e-28
>gi|21359972 kelch repeat and BTB (POZ) domain containing 7 [Homo
sapiens]
Length = 684
Score = 1393 bits (3606), Expect = 0.0
Identities = 684/684 (100%), Positives = 684/684 (100%)
Query: 1 MQSREDVPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTAHSAALLAQLKSFYDAR 60
MQSREDVPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTAHSAALLAQLKSFYDAR
Sbjct: 1 MQSREDVPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTAHSAALLAQLKSFYDAR 60
Query: 61 LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE
Sbjct: 61 LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
Query: 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA
Sbjct: 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
Query: 181 DAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVC 240
DAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVC
Sbjct: 181 DAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVC 240
Query: 241 HVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ 300
HVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ
Sbjct: 241 HVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ 300
Query: 301 MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCYD 360
MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCYD
Sbjct: 301 MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCYD 360
Query: 361 PYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLAD 420
PYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLAD
Sbjct: 361 PYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLAD 420
Query: 421 RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELI 480
RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELI
Sbjct: 421 RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELI 480
Query: 481 VVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPA 540
VVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPA
Sbjct: 481 VVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPA 540
Query: 541 RGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGT 600
RGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGT
Sbjct: 541 RGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGT 600
Query: 601 MLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARSESSTEWDLDGFSELDSESGSSS 660
MLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARSESSTEWDLDGFSELDSESGSSS
Sbjct: 601 MLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARSESSTEWDLDGFSELDSESGSSS 660
Query: 661 SFSDDEVWVQVAPQRNAQDQQGSL 684
SFSDDEVWVQVAPQRNAQDQQGSL
Sbjct: 661 SFSDDEVWVQVAPQRNAQDQQGSL 684
>gi|45333883 kelch repeat and BTB (POZ) domain-containing 6 [Homo
sapiens]
Length = 674
Score = 1248 bits (3230), Expect = 0.0
Identities = 605/674 (89%), Positives = 638/674 (94%)
Query: 1 MQSREDVPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTAHSAALLAQLKSFYDAR 60
MQSRED PRSRRLASPRGG+RPK+I KP+VSAFFTGPEELKDTAHSAALLAQLKSFYDAR
Sbjct: 1 MQSREDAPRSRRLASPRGGKRPKKIHKPTVSAFFTGPEELKDTAHSAALLAQLKSFYDAR 60
Query: 61 LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
LLCDVTIEVVTPGSGPGTGRLF CNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE
Sbjct: 61 LLCDVTIEVVTPGSGPGTGRLFPCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
Query: 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
SFEVLVDYCYTGRVSLSEANV+RLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA
Sbjct: 121 SFEVLVDYCYTGRVSLSEANVERLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
Query: 181 DAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVC 240
DAF H KLRSQAQSYIA NFKQLS MGSIREETLADLTLAQLLAVLRLDSLD+ESE+TVC
Sbjct: 181 DAFGHRKLRSQAQSYIAQNFKQLSHMGSIREETLADLTLAQLLAVLRLDSLDVESEQTVC 240
Query: 241 HVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ 300
HVAVQWLEAA KERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ
Sbjct: 241 HVAVQWLEAAPKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQ 300
Query: 301 MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCYD 360
MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLC D
Sbjct: 301 MRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCCD 360
Query: 361 PYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLAD 420
PYSGD+Y +PSPLT AHT+TVT+ AVC+SPDHDIYLAAQPR DLWVYKPAQNSWQQLAD
Sbjct: 361 PYSGDLYKVPSPLTCLAHTRTVTTLAVCISPDHDIYLAAQPRTDLWVYKPAQNSWQQLAD 420
Query: 421 RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELI 480
RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECY+V+RNQWALVAP+PHSF SF+L+
Sbjct: 421 RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYNVKRNQWALVAPLPHSFLSFDLM 480
Query: 481 VVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPA 540
V+++YLYA+NSKRM CYDPSHNMWL C SLKR+DFQEACVFN+EIYCICDIPVMKVYNP
Sbjct: 481 VIRDYLYALNSKRMFCYDPSHNMWLKCVSLKRNDFQEACVFNEEIYCICDIPVMKVYNPV 540
Query: 541 RGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGT 600
R EWR+++NIPL SET+NY+I+ H QKLLLITS TPQWKKNRVTVYEYD R DQWINIGT
Sbjct: 541 RAEWRQMNNIPLVSETNNYRIIKHGQKLLLITSRTPQWKKNRVTVYEYDIRGDQWINIGT 600
Query: 601 MLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARSESSTEWDLDGFSELDSESGSSS 660
LGLLQFDS F CL ARVYPSCLEPGQSF+TEE++ SESSTEWDL GFSE DSESGSSS
Sbjct: 601 TLGLLQFDSNFFCLSARVYPSCLEPGQSFLTEEEEIPSESSTEWDLGGFSEPDSESGSSS 660
Query: 661 SFSDDEVWVQVAPQ 674
S SDD+ WV+VAPQ
Sbjct: 661 SLSDDDFWVRVAPQ 674
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 243 bits (621), Expect = 3e-64
Identities = 176/622 (28%), Positives = 280/622 (45%), Gaps = 90/622 (14%)
Query: 42 DTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFT 101
D H+ ++L QLK+ YD L D+ +EV G+ FSC+RNVLAA PYF+SMFT
Sbjct: 28 DPFHACSILKQLKTMYDEGQLTDIVVEV-------DHGKTFSCHRNVLAAISPYFRSMFT 80
Query: 102 GGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACA 161
G+ ES Q V + V+AES +++++Y YT RV L+EANVQ L+ A+ + Q+ +++ CA
Sbjct: 81 SGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCA 140
Query: 162 SFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQ 221
++ LD N + FAD + H +L +++ YI F +++ E+ LT Q
Sbjct: 141 KYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTK-----EQEFLQLTKDQ 195
Query: 222 LLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVF-KCVRWMHFTEEDQDYLEG 280
L+++L D L+++ E V ++W E ER E+F KC+R+
Sbjct: 196 LISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRF------------- 242
Query: 281 LLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGM 340
P+++ D + ++ + KS V S+++ + QRLGM
Sbjct: 243 ----PLME----DTFIEKIPPQFAQAIAKSCVEKGPSNTNGCT------------QRLGM 282
Query: 341 CAKEMVIFF------GHPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHD 394
A EM+I F + C D +G ++ + P + VSPD+D
Sbjct: 283 TASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREV------GILVSPDND 336
Query: 395 IYLAAQPR-------------KDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILG 441
IY+A R D W+Y + N W L R G + Y G +Y +G
Sbjct: 337 IYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIG 396
Query: 442 GR--DPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKRMLCYDP 499
GR + LK VECY + N W V +P + + + +Y + + L Y+P
Sbjct: 397 GRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEP 456
Query: 500 SHNMWLNCASLKRSDFQE-ACVFNDEIYCICD-------IPVMKVYNPARGEWRRISNIP 551
+ W + Q A V+ D IY I + ++ Y+ +W R + P
Sbjct: 457 QKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFP 516
Query: 552 LDSETHNY-QIVNHDQKLLLITSTTPQWKKNRV-------TVYEYDTREDQWINI-GTML 602
D + Y ++V KL L T + V ++Y+YD DQW+ + T
Sbjct: 517 CDQSINPYLKLVLFQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPD 576
Query: 603 GLLQFDSGFICLCARVYPSCLE 624
L F C A++YP CL+
Sbjct: 577 RLWDLGRHFECAVAKLYPQCLQ 598
>gi|223468659 kelch repeat and BTB (POZ) domain containing 2 [Homo
sapiens]
Length = 623
Score = 218 bits (556), Expect = 1e-56
Identities = 173/672 (25%), Positives = 297/672 (44%), Gaps = 117/672 (17%)
Query: 35 TGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACP 94
T E +T ++ +LL QLK FY+ +L D+ + V G F C++ VLA
Sbjct: 3 TQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIV--------EGTEFPCHKMVLATCSS 54
Query: 95 YFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLE 154
YF++MF G+ ES+Q V + +VDA + ++++ Y YTG ++++++ V++LY + LQ+E
Sbjct: 55 YFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVE 114
Query: 155 YVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETL 214
V + C +L ++++ NC +L FAD F +L+ A+ + H F + ++
Sbjct: 115 DVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAV-----YHQDAF 169
Query: 215 ADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEED 274
L+ L+ +L D+L++E E TV A+ WLE + R + V +R +E
Sbjct: 170 MQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVT 229
Query: 275 Q-DYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAEN 333
Q + +GL P K V++G LYKS+ +
Sbjct: 230 QRAWFQGL--PPNDKSV---VVQG---------LYKSM-------------------PKF 256
Query: 334 PPQRLGMCAKEMVIFFGHPRD------PFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAV 387
RLGM +EM+IF + +CY P + +Y + SP TV
Sbjct: 257 FKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTV----- 311
Query: 388 CVSPDHDIYLAA--QPRKD--------------------LWVYKPAQNSWQQLADRLLCR 425
V+PD+DIY+A P K+ + + QN+W L R
Sbjct: 312 -VTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVR 370
Query: 426 EGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNY 485
+ GYIY +GG + + VE Y ++++W +V+P+P ++ +VV +
Sbjct: 371 IKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDC 430
Query: 486 LYAVNSKRMLCYDPSHNMWLNCASLKRS-DFQEACVFNDEIYCICDIPV----------- 533
+Y + M CY P + W+ A + S F A F D+I+ I + +
Sbjct: 431 IYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSG 490
Query: 534 --------MKVYNPARGEWRRISNIPLDSETHN-YQIVNHDQKLLLITSTTPQWKKNRVT 584
+++Y+ + EW+ +NIP + + V L + T ++ +
Sbjct: 491 TVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYV 550
Query: 585 VYEYDTREDQWINIGTMLGLLQFDSG--FICLCARVYPSCLE------PGQSFITEEDDA 636
Y+YD D+W + + +D G F C ++YPSCLE P F T
Sbjct: 551 TYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPTYLFST----- 605
Query: 637 RSESSTEWDLDG 648
+ + E++LDG
Sbjct: 606 --DGTEEFELDG 615
>gi|148664248 kelch domain containing 6 [Homo sapiens]
Length = 623
Score = 181 bits (460), Expect = 2e-45
Identities = 167/650 (25%), Positives = 282/650 (43%), Gaps = 104/650 (16%)
Query: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGM 104
HS LL ++++ + + DV + G F C+R VLAA PYFK+MFT G+
Sbjct: 13 HSLNLLNKIQNMKELAEMIDVVLTA--------EGEKFPCHRLVLAAFSPYFKAMFTCGL 64
Query: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
E Q V ++D+ AES VL++Y Y + ++ ANVQ + A+ +Q+E V C ++
Sbjct: 65 LECNQREVILYDITAESVSVLLNYMYNAALEINNANVQTVAMAAYFMQMEEVFSVCQKYM 124
Query: 165 ARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLA 224
+D +NC I FA L +++ Y+ +F ++ S+ EE L ++ + Q L
Sbjct: 125 MDHMDASNCLGIYYFAKQIGAEDLSDRSKKYLYQHFAEV----SLHEEIL-EIEVHQFLT 179
Query: 225 VLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLL-- 282
+++ D L+I E ++ + ++W+ + R E+ K VR + +L L
Sbjct: 180 LIKSDDLNISREESILDLVLRWVNHNKELRTVHLVELLKQVR---LELVNPSFLRQALRR 236
Query: 283 -TKPIVKKYCLDVIEGA-----------LQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSA 330
T + C+D+I+ A L +RYG L+ + N+SS S +
Sbjct: 237 NTMLLCDADCVDIIQNAFKAIKTPQQHSLNLRYGMETTSLLLCIGNNSSGIRSRHRSYG- 295
Query: 331 AENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSP-----LTSFAHTKTVTSS 385
D CYDP S Y + SP L + + ++
Sbjct: 296 -----------------------DASFCYDPVSRKTYFISSPKYGEGLGTVCTGVVMENN 332
Query: 386 AVCVSPDHDI-YLAAQPRKDLWVYK---PAQNSWQQLADRLLCREGMDVAYLNGYIYILG 441
+ V+ + L+ Q K++ +Y+ W++L RE + ++ +Y++G
Sbjct: 333 TIIVAGEASASKLSRQKNKNVEIYRYHDRGNQFWEKLCTAEF-RELYALGSIHNDLYVIG 391
Query: 442 GRDPITGVKL--KEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVN--------- 490
G+ I L V+ YSV+R+ W V+P+P ++ V N LY +
Sbjct: 392 GQMKIKNQYLITNCVDKYSVERDNWKRVSPLPLQLACHAVVTVNNKLYVIGGWTPQMDLP 451
Query: 491 -------SKRMLCYDPSHNMWLNCASLKRSDFQ-EACVFNDEIYCICDI----------- 531
S ++L YDPS + W A +K S ++ V N EIY + I
Sbjct: 452 DEEPDRLSNKLLQYDPSQDQWSVRAPMKYSKYRFSTAVVNSEIYVLGGIGCVGQDKGQVR 511
Query: 532 ---PVMKVYNPARGEWRRISNIP---LDSETHNYQIVNHDQKLLLITSTTPQWKKNRVT- 584
V+++YNP WR +P L T++ D KL + + ++
Sbjct: 512 KCLDVVEIYNPDGDFWREGPPMPSPLLSLRTNSTNAGAVDGKLYVCGGFHGADRHEVISK 571
Query: 585 -VYEYDTREDQWINIGTMLGLLQFDSGFICLCARVYPSCLEPGQSFITEE 633
+ E D E+QW N+ + +L DS +CL AR+ P L P S + EE
Sbjct: 572 EILELDPWENQW-NV-VAINVLMHDSYDVCLVARMNPRDLIPPPSDLVEE 619
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 174 bits (441), Expect = 2e-43
Identities = 147/529 (27%), Positives = 233/529 (44%), Gaps = 64/529 (12%)
Query: 42 DTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFT 101
D AH+ +LL L R DVT+E GR F +R VLAAA PYF++MF
Sbjct: 14 DPAHALSLLRGLSQLRAERKFLDVTLEAAG-------GRDFPAHRAVLAAASPYFRAMFA 66
Query: 102 GGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACA 161
G + ES+ V +H V + ++L+D+ YTGRV++S N + L A+D+LQ V+EAC
Sbjct: 67 GQLRESRAERVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACG 126
Query: 162 SFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQ 221
+FL ++LDL NC + FA+AF L S AQ +I L +G + E L L LA+
Sbjct: 127 AFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFI------LRHVGELGAEQLERLPLAR 180
Query: 222 LLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGL 281
LL LR D L + E +A++W+ A R ++ + VR + F L +
Sbjct: 181 LLRYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVR-LPFVRRFY-LLAHV 238
Query: 282 LTKPIVKKY--CLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLG 339
+P+V + CL ++ A + P P S+
Sbjct: 239 EAEPLVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTG--------------- 283
Query: 340 MCAKEMVIFFGHPRD-----PFLCYDPYSGD---IYTMPSPLTSFAHTKTVTSSAVCVSP 391
A+ +V+ G +D CY+P +G + P L ++ + + V+
Sbjct: 284 -LAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFPDHLGG-GYSIVALGNDIYVTG 341
Query: 392 DHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKL 451
D ++ +W Y + N W ++A L RE + L+G +Y+ V
Sbjct: 342 GSD---GSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLLYV---------VAA 389
Query: 452 KEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKR------MLCYDPSHNMW- 504
E Y + W + P+ + + + LYA+ S M CYDP ++W
Sbjct: 390 DSTERYDHTTDSWEALQPMTYPMDNCSTTACRGRLYAIGSLAGKETMVMQCYDPDTDLWS 449
Query: 505 -LNCASLKRSDF-QEACVFNDEIYCICDIPV-MKVYNPARGEWRRISNI 550
++C L F + N +Y + D + VYNP R EW +I ++
Sbjct: 450 LVDCGQLPPWSFAPKTATLNGLMYFVRDDSAEVDVYNPTRNEWDKIPSM 498
Score = 43.1 bits (100), Expect = 8e-04
Identities = 33/118 (27%), Positives = 53/118 (44%), Gaps = 14/118 (11%)
Query: 358 CYDPYSGDIYTMPS----PLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQN 413
CYDP + D++++ P SFA KT T + + +Y ++ VY P +N
Sbjct: 440 CYDPDT-DLWSLVDCGQLPPWSFA-PKTATLNGL-------MYFVRDDSAEVDVYNPTRN 490
Query: 414 SWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVP 471
W ++ G +A L G +Y+ GG D T VE Y + W++V +P
Sbjct: 491 EWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDN-TFELSDVVEAYDPETRAWSVVGRLP 547
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 171 bits (433), Expect = 2e-42
Identities = 136/511 (26%), Positives = 237/511 (46%), Gaps = 67/511 (13%)
Query: 60 RLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDA 119
R LCDV + V G ++++ +R +L+A PYF++MFTG + ES+Q V + D+D
Sbjct: 65 RELCDVVLVV-------GAKKIYA-HRVILSACSPYFRAMFTGELAESRQTEVVIRDIDE 116
Query: 120 ESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKF 179
+ E+L+D+ YT ++++ E NVQ L A+ +LQL ++EAC FL R+LD +NC I F
Sbjct: 117 RAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAF 176
Query: 180 ADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTV 239
AD +L A + HNF+++ + E L QL+ ++ D L++ SE V
Sbjct: 177 ADTHSCRELLRIADKFTQHNFQEV-----MESEEFMLLPANQLIDIISSDELNVRSEEQV 231
Query: 240 CHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLL-TKPIVK--KYCLDVIE 296
+ + W++ + +ER P +V + VR + + +L G + + P++K + C D+++
Sbjct: 232 FNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPK---FLVGTVGSDPLIKSDEECRDLVD 288
Query: 297 GALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPF 356
A K+ + +P L+ P++ C + + G
Sbjct: 289 EA----------KNYLLLP-------QERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDA 331
Query: 357 LC----YDPYSGDIYTMPSPLTS--FAHTKTVTSSAVCVSPDHD--IYLAAQPRKDLWVY 408
+ YDP + + + M + ++ +V + HD YL + R Y
Sbjct: 332 ISSVERYDPQTNE-WRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVER-----Y 385
Query: 409 KPAQNSW-QQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALV 467
P N W +A CR + VA L G++Y +GG+D ++ + + VE Y + N+W V
Sbjct: 386 DPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNI--VERYDPKENKWTRV 443
Query: 468 APVPHSFYSFELIVVQNYLYAVNS-------KRMLCYDPSHNMWLNCASL-KRSDFQEAC 519
A + + V+ +LYAV + Y+P N W A + R
Sbjct: 444 ASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCA 503
Query: 520 VFNDEIYCI------CDIPVMKVYNPARGEW 544
V+ D IY + ++ + YNP +W
Sbjct: 504 VYQDMIYAVGGRDDTTELSSAERYNPRTNQW 534
Score = 57.4 bits (137), Expect = 4e-08
Identities = 44/156 (28%), Positives = 66/156 (42%), Gaps = 17/156 (10%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWAL- 466
Y P N W+ +A R G+ V+ L+ +Y +GG D + L VE Y + NQW+
Sbjct: 338 YDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSS--YLNSVERYDPKTNQWSSD 395
Query: 467 VAPVPHSFYSFELIVVQNYLYAVNSKRMLC-------YDPSHNMWLNCASLKRSDFQEA- 518
VAP S + V+ +LYAV + + YDP N W AS+ A
Sbjct: 396 VAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAV 455
Query: 519 CVFNDEIYCI------CDIPVMKVYNPARGEWRRIS 548
V +Y + + ++ YNP W I+
Sbjct: 456 AVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIA 491
Score = 57.4 bits (137), Expect = 4e-08
Identities = 40/152 (26%), Positives = 66/152 (43%), Gaps = 16/152 (10%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALV 467
Y P +N W ++A R G+ VA L G++Y +GG D + L VE Y+ Q N+W +
Sbjct: 433 YDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTS--PLNTVERYNPQENRWHTI 490
Query: 468 APVPHSFYSFELIVVQNYLYAVNSKRMLC-------YDPSHNMWLNCASL-KRSDFQEAC 519
AP+ V Q+ +YAV + Y+P N W ++ R
Sbjct: 491 APMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLA 550
Query: 520 VFNDEIYCI------CDIPVMKVYNPARGEWR 545
V N ++ + + ++V++P WR
Sbjct: 551 VVNGQLMAVGGFDGTTYLKTIEVFDPDANTWR 582
Score = 34.7 bits (78), Expect = 0.30
Identities = 27/122 (22%), Positives = 50/122 (40%), Gaps = 21/122 (17%)
Query: 447 TGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNS-------KRMLCYDP 499
+G + VE Y Q N+W +VA + + V+ + LYAV + YDP
Sbjct: 328 SGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDP 387
Query: 500 SHNMWLNCASLKRS-----------DFQEACVFNDEIYCICDIPVMKVYNPARGEWRRIS 548
N W + + + F A D + C + +++ Y+P +W R++
Sbjct: 388 KTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSC---LNIVERYDPKENKWTRVA 444
Query: 549 NI 550
++
Sbjct: 445 SM 446
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 159 bits (401), Expect = 1e-38
Identities = 127/488 (26%), Positives = 209/488 (42%), Gaps = 45/488 (9%)
Query: 82 FSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANV 141
FSC+R VLAAA YF++MF + E + + + VDAE+ L+DY YT + +++ NV
Sbjct: 83 FSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLDYTYTSKALITKQNV 142
Query: 142 QRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFK 201
QR+ A+++ Q + +ACASFL L+ NC IL+ AD L+ Q QSYI NF
Sbjct: 143 QRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLADTHSLDSLKKQVQSYIIQNFV 202
Query: 202 QLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEV 261
Q+ + E DL + L +L+ D L + E V + W+ ER V
Sbjct: 203 QI-----LNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMSWVRHKPSERLCLLPYV 257
Query: 262 FKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSS 321
+ VR + ++E + P++++ C +V + R L
Sbjct: 258 LENVRLPLL--DPWYFVETVEADPLIRQ-CPEVFPLLQEARMYHL--------------- 299
Query: 322 SSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFL----CYDPYSG---DIYTMPSPLT 374
S N ++S P M+I + F+ C DP ++ +P
Sbjct: 300 -SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEH 358
Query: 375 SFAHTKTVTSSAVCVSPDHDIYLAA--QPRKDLWVYKPAQNSWQQLADRLLCREGMDVAY 432
CV+ +++Y++ + + D+W Y + N W Q+ + R +
Sbjct: 359 ELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVV 418
Query: 433 LNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVN-- 490
L G +Y++GG D + ++ VE Y N W+ AP+ SF + LY +
Sbjct: 419 LGGKVYVIGGFDGLQ--RINNVETYDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGG 476
Query: 491 ------SKRMLCYDPSHNMW-LNCASLKRSDFQEACVFNDEIYCICD-IPVMKVYNPARG 542
+ + CYDPS N W L A + A F D IY + + + Y+P
Sbjct: 477 PNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAMRALYAYSPLED 536
Query: 543 EWRRISNI 550
W ++ +
Sbjct: 537 SWCLVTQL 544
Score = 34.7 bits (78), Expect = 0.30
Identities = 28/107 (26%), Positives = 47/107 (43%), Gaps = 12/107 (11%)
Query: 343 KEMVIFFGHPR-----DPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYL 397
K++ + G P D CYDP S + +++ + + K + + VS IY+
Sbjct: 468 KKLYVIGGGPNGKLATDKTQCYDP-STNKWSLKAAMP--VEAKCINA----VSFRDRIYV 520
Query: 398 AAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRD 444
+ L+ Y P ++SW + R +A N +YI GGRD
Sbjct: 521 VGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRD 567
Score = 34.3 bits (77), Expect = 0.39
Identities = 23/100 (23%), Positives = 39/100 (39%), Gaps = 15/100 (15%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALV 467
Y P+ N W A + + ++ IY++GG ++ + YS + W LV
Sbjct: 489 YDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGA-------MRALYAYSPLEDSWCLV 541
Query: 468 APVPHSFYSFELIVVQNYLYAVNSK--------RMLCYDP 499
+ H S + N LY + +LC+DP
Sbjct: 542 TQLSHERASCGIAPCNNRLYITGGRDEKNEVIATVLCWDP 581
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 155 bits (393), Expect = 9e-38
Identities = 144/530 (27%), Positives = 234/530 (44%), Gaps = 69/530 (13%)
Query: 43 TAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTG 102
++H+ +L F D+RL DV I V G+ F C+R VL+A YF++MF
Sbjct: 46 SSHAENILQIFNEFRDSRLFTDVIICV--------EGKEFPCHRAVLSACSSYFRAMFCN 97
Query: 103 GMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACAS 162
ES++ V ++ + AE+ E + Y YTG+V ++ NVQ L+ S + Q+ +R+ACA
Sbjct: 98 DHRESREMLVEINGILAEAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAK 157
Query: 163 FLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQL 222
FL +LD NC I +FAD L ++ +++ F+ +S + E +L +L
Sbjct: 158 FLEEQLDPCNCLGIQRFADTHSLKTLFTKCKNFALQTFEDVS-----QHEEFLELDKDEL 212
Query: 223 LAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVR--------WMHFTEED 274
+ + D L I E V ++W+ A R P E+ VR ++ E D
Sbjct: 213 IDYICSDELVIGKEEMVFEAVMRWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVD 272
Query: 275 QDYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENP 334
Q L+ C ++ A RY L + + P S+ S +V
Sbjct: 273 Q-----LIQN---SPECYQLLHEA--RRYHILGNEMMSPRTRPRRSTGYSEVIVV----- 317
Query: 335 PQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHD 394
+G C E V F P CYDP +G+ ++ + L F T + AVC + +D
Sbjct: 318 ---VGGC--ERVGGFNLPYTE--CYDPVTGEWKSL-AKLPEF----TKSEYAVC-ALRND 364
Query: 395 IYLAAQ--PRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLK 452
I ++ +D+W+Y N W ++A R +A L G +Y++GG D +L
Sbjct: 365 ILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQN--RLS 422
Query: 453 EVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVN--------SKRMLCYDPSHNMW 504
VECY N+W VAP+ + S + L+ + S ++ YDP N W
Sbjct: 423 SVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETNSW 482
Query: 505 LNCASLKRSDFQEACV----FNDEIYCICDI-PVMKVYNPARGEWRRISN 549
L A++ + C+ N+ IY + + Y+P W + N
Sbjct: 483 LLRAAI---PIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQN 529
Score = 41.6 bits (96), Expect = 0.002
Identities = 41/176 (23%), Positives = 65/176 (36%), Gaps = 26/176 (14%)
Query: 358 CYDPYSGDIYTMPSPLTSFAHTKTVTSSA-----VCVSPDHDIYLAAQPRKDLWVYKPAQ 412
CYD +S +T +PL + VTS + PD + + Y P
Sbjct: 426 CYDSFSNR-WTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTC-----SDKVQSYDPET 479
Query: 413 NSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPH 472
NSW A + + + LN IY+ GG K + CY + W V
Sbjct: 480 NSWLLRAAIPIAKRCITAVSLNNLIYVAGGLT-------KAIYCYDPVEDYWMHVQNTFS 532
Query: 473 SFYSFELIVVQNYLYAVNSKR--------MLCYDPSHNMWLNCASLKRSDFQEACV 520
+ + V +Y + +R +LCYDP+ ++ A++ R CV
Sbjct: 533 RQENCGMSVCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCV 588
Score = 41.2 bits (95), Expect = 0.003
Identities = 26/97 (26%), Positives = 43/97 (44%), Gaps = 1/97 (1%)
Query: 389 VSPDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITG 448
VS ++ IY+A K ++ Y P ++ W + + +E ++ NG IYILGGR G
Sbjct: 498 VSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMSVCNGKIYILGGRRE-NG 556
Query: 449 VKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNY 485
+ CY + VA +P + + Y
Sbjct: 557 EATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRY 593
Score = 40.8 bits (94), Expect = 0.004
Identities = 35/172 (20%), Positives = 72/172 (41%), Gaps = 15/172 (8%)
Query: 437 IYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYS-FELIVVQNYLYA----VNS 491
I ++GG + + G L ECY +W +A +P S + + ++N + +NS
Sbjct: 315 IVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINS 374
Query: 492 KRMLCYDPSHNMWLNCASLKRSDFQ-EACVFNDEIYCICD------IPVMKVYNPARGEW 544
+ + Y+ N+W+ ASL + ++ + V ++Y + + ++ Y+ W
Sbjct: 375 RDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRW 434
Query: 545 RRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWI 596
++ PL + + + KL +I P V YD + W+
Sbjct: 435 TEVA--PLKEAVSSPAVTSCVGKLFVI-GGGPDDNTCSDKVQSYDPETNSWL 483
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 153 bits (386), Expect = 6e-37
Identities = 155/579 (26%), Positives = 244/579 (42%), Gaps = 62/579 (10%)
Query: 44 AHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGG 103
AH + +LLCDV I +R VLAA PYF +MFTG
Sbjct: 31 AHMGKAFKVMNELRSKQLLCDVMIVAEDVE--------IEAHRVVLAACSPYFCAMFTGD 82
Query: 104 MYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASF 163
M ES+ + + DVD ++ L+DY YT + ++E NVQ L A+ +LQL VR+ C F
Sbjct: 83 MSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDF 142
Query: 164 LARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLL 223
L +L TNC I FAD L QA +Y +F ++ + EE L+ L+L Q+
Sbjct: 143 LQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEV----MLGEEFLS-LSLDQVC 197
Query: 224 AVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLT 283
+++ D L + SE V + W+ + R A++ + VR +DYL +
Sbjct: 198 SLISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVR---LPLLPRDYLVQTVE 254
Query: 284 KPIVKK---YCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGM 340
+ + K C D + A++ L + L+ P + P+
Sbjct: 255 EEALIKNNNTCKDFLIEAMKYHLLPLDQRLLIKNPRTK----------------PRTPVS 298
Query: 341 CAKEMVIFFGHPRDPFL---CYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYL 397
K M++ G CYD + D + + L S V A V
Sbjct: 299 LPKVMIVVGGQAPKAIRSVECYD-FEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNG 357
Query: 398 AAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECY 457
+ + R + VY ++ W +A R + A LN +Y +GG D TG L VE Y
Sbjct: 358 SLRVR-TVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTG--LASVEAY 414
Query: 458 SVQRNQWALVAPVPHSFYSFELIVVQNYLYAVN-----SKRMLC----YDPSHNMWLNCA 508
S + N+W VAP+ S + VV+ LYAV S++ L Y+P+ N W+ A
Sbjct: 415 SYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVA 474
Query: 509 SLK-RSDFQEACVFNDEIYCI--CDIPVMK----VYNPARGEWRRISNIPLDSETHNYQI 561
+ R V + ++Y D P+++ VY+P W++++++ +
Sbjct: 475 DMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCA 534
Query: 562 VNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGT 600
VN LL N +V Y+ D+W + T
Sbjct: 535 VNG----LLYVVGGDDGSCNLASVEYYNPVTDKWTLLPT 569
Score = 47.0 bits (110), Expect = 6e-05
Identities = 36/177 (20%), Positives = 79/177 (44%), Gaps = 19/177 (10%)
Query: 439 ILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNS------- 491
++GG+ P ++ VECY + ++W +A +P ++ + ++YAV
Sbjct: 305 VVGGQAPKA---IRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRV 361
Query: 492 KRMLCYDPSHNMWLNCASL-KRSDFQEACVFNDEIYCI------CDIPVMKVYNPARGEW 544
+ + YD + W + AS+ +R A V ND +Y + + ++ Y+ EW
Sbjct: 362 RTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEW 421
Query: 545 RRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTM 601
++ P+++ + + + KL + ++ TV +Y+ ++WI + M
Sbjct: 422 FFVA--PMNTRRSSVGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADM 476
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 149 bits (377), Expect = 6e-36
Identities = 127/562 (22%), Positives = 229/562 (40%), Gaps = 70/562 (12%)
Query: 41 KDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMF 100
KD+ H L ++FY L D+T++ + G +F C+R VLAA YFK+MF
Sbjct: 14 KDSTHPVDFLDAFRTFYLDGLFTDITLQCPS-------GIIFHCHRAVLAACSNYFKAMF 66
Query: 101 TGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREAC 160
T M E + + + + + E LV+Y YT ++ +++ NVQ L A+D+LQ V++AC
Sbjct: 67 TADMKEKFKNKIKLSGIHHDILEGLVNYAYTSQIEITKRNVQSLLEAADLLQFLSVKKAC 126
Query: 161 ASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLA 220
FL R LD+ NC + FA+ +L +++ + FK++ ++E +++L
Sbjct: 127 ERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILCSKFKEV-----WQQEEFLEISLE 181
Query: 221 QLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEG 280
+ L +L +L + E + ++W + R + + + D YL+
Sbjct: 182 KFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECLYNLLSYIN----IDIDPVYLKT 237
Query: 281 LLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSS----------------- 323
L +++ CL + + L+Y +L P+ S S+
Sbjct: 238 ALG---LQRSCL-----LTENKIRSLIYNALNPMHKEISQRSTATMYIIGGYYWHPLSEV 289
Query: 324 ------SNSLVSAAENPPQR-----LGMCAKEMVIFFGHPRDPFLCYDPY-----SGDIY 367
+N + AE P + + + G+ D D D +
Sbjct: 290 HIWDPLTNVWIQGAEIPDYTRESYGVTCLGPNIYVTGGYRTDNIEALDTVWIYNSESDEW 349
Query: 368 TMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREG 427
T P+ + + + CV Y P ++ Y P + W +A+ +
Sbjct: 350 TEGLPMLNARYYHCAVTLGGCVYALGG-YRKGAPAEEAEFYDPLKEKWIPIANMIKGVGN 408
Query: 428 MDVAYLNGYIYILGGRDPITG-VKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYL 486
L+ IY++GG G +V+ Y+ N+W+L+ PH Y + +N L
Sbjct: 409 ATACVLHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKL 468
Query: 487 YAVNSKRML--CYDPSHNMWLNCASLKRSDFQ-EACVFNDEIYCI--------CDIPVMK 535
Y V + + CYDP N W A + + A + N IY + ++
Sbjct: 469 YLVGGQTTITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIE 528
Query: 536 VYNPARGEWRRISNIPLDSETH 557
Y+P +W + N+P +H
Sbjct: 529 KYDPDLNKWEIVGNLPSAMRSH 550
Score = 52.4 bits (124), Expect = 1e-06
Identities = 35/124 (28%), Positives = 55/124 (44%), Gaps = 6/124 (4%)
Query: 362 YSGDIYTMPSPLTSFAHTKTVTSSAVCVSP-DHDIYLAAQPRKDLWVYKPAQNSWQQLAD 420
Y+ DI S +TS H + +C P ++ +YL Y P QN W+++A
Sbjct: 439 YNSDINEW-SLITSSPHPEY----GLCSVPFENKLYLVGGQTTITECYDPEQNEWREIAP 493
Query: 421 RLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELI 480
+ R +NG IY+ GG G L+ +E Y N+W +V +P + S +
Sbjct: 494 MMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGCV 553
Query: 481 VVQN 484
V N
Sbjct: 554 CVYN 557
Score = 38.5 bits (88), Expect = 0.021
Identities = 35/181 (19%), Positives = 62/181 (34%), Gaps = 17/181 (9%)
Query: 350 GHPRDPFLCYDPYSGDIYTMPSPLTSFAH-TKTVTSSAVCVSPDHDIYLAAQPRKDLWVY 408
G P + YDP + + + + T V + V H Y + + Y
Sbjct: 380 GAPAEEAEFYDPLKEKWIPIANMIKGVGNATACVLHDVIYVIGGHCGYRGSCTYDKVQSY 439
Query: 409 KPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVA 468
N W + G+ +Y++GG+ IT ECY ++N+W +A
Sbjct: 440 NSDINEWSLITSSPHPEYGLCSVPFENKLYLVGGQTTIT-------ECYDPEQNEWREIA 492
Query: 469 PVPHSFYSFELIVVQNYLYAVNS---------KRMLCYDPSHNMWLNCASLKRSDFQEAC 519
P+ +++ +Y + + YDP N W +L + C
Sbjct: 493 PMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIVGNLPSAMRSHGC 552
Query: 520 V 520
V
Sbjct: 553 V 553
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 149 bits (376), Expect = 8e-36
Identities = 134/534 (25%), Positives = 225/534 (42%), Gaps = 75/534 (14%)
Query: 21 RPKRISKPSVSAFFTGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGR 80
R R S S++ + ++++ ++L L RL DV + R
Sbjct: 9 RKSRASSGSINIYL-----FHKSSYADSVLTHLNLLRQQRLFTDVLLHA--------GNR 55
Query: 81 LFSCNRNVLAAACPYFKSMFTGGMYESQQASVTM-HDVDAESFEVLVDYCYTGRVSLSEA 139
F C+R VLAA YF++MF+GG+ ESQ + V + + E E+L+DY Y+ RV ++E
Sbjct: 56 TFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEE 115
Query: 140 NVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHN 199
N + L A DML+ + +R+ACA FL + L TNC +L +DA KL + N
Sbjct: 116 NAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSN 175
Query: 200 FKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAA 259
F+ + + E L ++ +L + L+ E ER V A+ W+ K+R
Sbjct: 176 FQTIR-----KNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLP 230
Query: 260 EVFKCVRWMHFTE---EDQDYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPN 316
E+ + VR + +E L+TK K +++E A++ + L
Sbjct: 231 ELLQTVRLALLPAIYLMENVAMEELITKQRKSK---EIVEEAIRCKLKIL---------- 277
Query: 317 SSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYT-------- 368
++ +V++ P++ G F F+C Y D
Sbjct: 278 ------QNDGVVTSLCARPRKTGHA------LFLLGGQTFMCDKLYLVDQKAKEIIPKAD 325
Query: 369 MPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGM 428
+PSP F+ + + ++ KD+WVY W + A L+ R G
Sbjct: 326 IPSPRKEFSACAIGCKVYITGGRGSENGVS----KDVWVYDTLHEEWSKAAPMLVARFGH 381
Query: 429 DVAYLNGYIYILGGRDPITG-------VKLKEVECYSVQRNQWALVAPVPHSFYSFELIV 481
A L +Y++GG TG V LK+VE Y N+W +VAP+ + ++
Sbjct: 382 GSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVS 441
Query: 482 VQNYLYAVNS--------KRMLCYDPSHNMWLNCASLKRS-DFQEACVFNDEIY 526
+ L+A ++ CYD N W A+ + + A V ++I+
Sbjct: 442 AKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIF 495
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 147 bits (372), Expect = 2e-35
Identities = 141/574 (24%), Positives = 241/574 (41%), Gaps = 88/574 (15%)
Query: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGM 104
H+ +LAQ+ + + CDV ++V F +R VLAA+ PYF ++FTGGM
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQES--------FKAHRLVLAASSPYFAALFTGGM 70
Query: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
ES + V + ++A F++L+D+ YTG V++ NVQ L A+DMLQL V C FL
Sbjct: 71 KESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFL 130
Query: 165 ARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLA 224
++D NC I +F++ H L +++YI +F ++ EE LA LT QL+
Sbjct: 131 KGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHS----GEEFLA-LTKDQLIK 185
Query: 225 VLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRW--------MHFTEEDQD 276
+LR + L IE E V A+QW+ +R EV +R+ + + E D
Sbjct: 186 ILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSD 245
Query: 277 YLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSS--------------- 321
+ + + ++K+YC +V + + ++ L S V P +
Sbjct: 246 FNLRVALQTLLKEYC-EVCKSPKENKFCSFLQTSKVR-PRKKARKYLYAVGGYTRLQGGR 303
Query: 322 -SSSNSL---------------VSAAENPPQRLGMCA-KEMVIFFGHPRDPFL-----CY 359
S S +L VS+ LG+ MV G +D + CY
Sbjct: 304 WSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECY 363
Query: 360 DPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDI--YLAAQPRKDLWVYKPAQNSWQQ 417
DP + T + S H + VC + + ++ A+ + + P +N W+
Sbjct: 364 DPVTKQWTT----VASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEV 419
Query: 418 LADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSF 477
+ + + R + G IY++GG G++L+ E Y +W+ + P+
Sbjct: 420 VGNMAVSRYYFGCCEMQGLIYVIGGISN-EGIELRSFEVYDPLSKRWSPLPPMGTRRAYL 478
Query: 478 ELIVVQNYLYAVNS--------KRMLCYDPSHNMWLNCASLK--RSDFQEACV------- 520
+ + + +Y+V + Y W+ AS+K R+ V
Sbjct: 479 GVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVS 538
Query: 521 ----FNDEIYCICDIPVMKVYNPARGEWRRISNI 550
+ + + ++VYNP W I N+
Sbjct: 539 GGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNM 572
Score = 45.8 bits (107), Expect = 1e-04
Identities = 43/202 (21%), Positives = 72/202 (35%), Gaps = 20/202 (9%)
Query: 415 WQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSF 474
W ++ R G+ V L G +Y +GG + ECY QW VA + H
Sbjct: 323 WTTVSSLHQARSGLGVTVLGGMVYAIGGEK--DSMIFDCTECYDPVTKQWTTVASMNHPR 380
Query: 475 YSFELIVVQNYLYAVN-------SKRMLCYDPSHNMWLNCASLKRSDFQ-EACVFNDEIY 526
+ V +YA+ + +DP N W ++ S + C IY
Sbjct: 381 CGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIY 440
Query: 527 CI-------CDIPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWK 579
I ++ +VY+P W S +P Y V + + +
Sbjct: 441 VIGGISNEGIELRSFEVYDPLSKRW---SPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
Query: 580 KNRVTVYEYDTREDQWINIGTM 601
TV +Y E++W+ + +M
Sbjct: 498 DALHTVEKYSFEEEKWVEVASM 519
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 147 bits (370), Expect = 4e-35
Identities = 132/522 (25%), Positives = 225/522 (43%), Gaps = 75/522 (14%)
Query: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGM 104
H+ +LAQ+ + + CDV ++V F +R VLAA+ PYF ++FTGGM
Sbjct: 19 HAQLILAQINKMRNGQHFCDVQLQVGQES--------FKAHRLVLAASSPYFAALFTGGM 70
Query: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
ES + V + ++A F++L+D+ YTG V++ NVQ L A+DMLQL V C FL
Sbjct: 71 KESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVHLCCEFL 130
Query: 165 ARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLA 224
++D NC I +F++ H L +++YI +F ++ EE LA LT QL+
Sbjct: 131 KGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHS----GEEFLA-LTKDQLIK 185
Query: 225 VLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRW--------MHFTEEDQD 276
+LR + L IE E V A+QW+ +R EV +R+ + + E D
Sbjct: 186 ILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVSD 245
Query: 277 YLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSS--------------- 321
+ + + ++K+YC +V + + ++ L S V P +
Sbjct: 246 FNLRVALQTLLKEYC-EVCKSPKENKFCSFLQTSKVR-PRKKARKYLYAVGGYTRLQGGR 303
Query: 322 -SSSNSL---------------VSAAENPPQRLGMCA-KEMVIFFGHPRDPFL-----CY 359
S S +L VS+ LG+ MV G +D + CY
Sbjct: 304 WSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKDSMIFDCTECY 363
Query: 360 DPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDI--YLAAQPRKDLWVYKPAQNSWQQ 417
DP + T + S H + VC + + ++ A+ + + P +N W+
Sbjct: 364 DPVTKQWTT----VASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEV 419
Query: 418 LADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSF 477
+ + + R + G IY++GG G++L+ E Y +W+ + P+
Sbjct: 420 VGNMAVSRYYFGCCEMQGLIYVIGGISN-EGIELRSFEVYDPLSKRWSPLPPMGTRRAYL 478
Query: 478 ELIVVQNYLYAVNS--------KRMLCYDPSHNMWLNCASLK 511
+ + + +Y+V + Y W+ AS+K
Sbjct: 479 GVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMK 520
Score = 45.8 bits (107), Expect = 1e-04
Identities = 43/202 (21%), Positives = 72/202 (35%), Gaps = 20/202 (9%)
Query: 415 WQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSF 474
W ++ R G+ V L G +Y +GG + ECY QW VA + H
Sbjct: 323 WTTVSSLHQARSGLGVTVLGGMVYAIGGEK--DSMIFDCTECYDPVTKQWTTVASMNHPR 380
Query: 475 YSFELIVVQNYLYAVN-------SKRMLCYDPSHNMWLNCASLKRSDFQ-EACVFNDEIY 526
+ V +YA+ + +DP N W ++ S + C IY
Sbjct: 381 CGLGVCVCYGAIYALGGWVGAEIGNTIERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIY 440
Query: 527 CI-------CDIPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWK 579
I ++ +VY+P W S +P Y V + + +
Sbjct: 441 VIGGISNEGIELRSFEVYDPLSKRW---SPLPPMGTRRAYLGVAALNDCIYSVGGWNETQ 497
Query: 580 KNRVTVYEYDTREDQWINIGTM 601
TV +Y E++W+ + +M
Sbjct: 498 DALHTVEKYSFEEEKWVEVASM 519
Score = 35.4 bits (80), Expect = 0.18
Identities = 26/81 (32%), Positives = 34/81 (41%), Gaps = 1/81 (1%)
Query: 407 VYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWAL 466
VY P W L R + VA LN IY +GG + T L VE YS + +W
Sbjct: 457 VYDPLSKRWSPLPPMGTRRAYLGVAALNDCIYSVGGWNE-TQDALHTVEKYSFEEEKWVE 515
Query: 467 VAPVPHSFYSFELIVVQNYLY 487
VA + ++ V LY
Sbjct: 516 VASMKVPRAGMCVVAVNGLLY 536
Score = 34.7 bits (78), Expect = 0.30
Identities = 17/57 (29%), Positives = 26/57 (45%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQW 464
Y + W ++A + R GM V +NG +Y+ GGR + Y V R +W
Sbjct: 506 YSFEEEKWVEVASMKVPRAGMCVVAVNGLLYVSGGRSSSHDFLAPDTHRYEVFRLKW 562
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 147 bits (370), Expect = 4e-35
Identities = 144/564 (25%), Positives = 231/564 (40%), Gaps = 66/564 (11%)
Query: 61 LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
LLCD+ + V + ++ VLA+ PYF +MFT M ES+Q VT+HD+D +
Sbjct: 90 LLCDIVLHVAA--------KEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141
Query: 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
+ + LV + YT + + E NVQ L A+ +LQL VR+AC FL +LD +NC I FA
Sbjct: 142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFA 201
Query: 181 DAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVC 240
DA L A Y+ +F ++ + E L L Q+L ++ DSL++ SE V
Sbjct: 202 DAHSCSDLLKAAHRYVLQHFVDVA-----KTEEFMLLPLKQVLELVSSDSLNVPSEEEVY 256
Query: 241 HVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKY---CLDVIEG 297
+ W++ R + KCVR + +D+L G + + ++ C D++
Sbjct: 257 RAVLSWVKHDVDARRQHVPRLMKCVRLPLLS---RDFLLGHVDAESLVRHHPDCKDLLIE 313
Query: 298 ALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENP-PQRLGMCAKEMVIFFGHPRDPF 356
AL+ +P +S + E P + + G
Sbjct: 314 ALKFHL----------LPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCE--- 360
Query: 357 LCYDPYSGDIYTMPSPLTSFAH--TKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNS 414
YD + + + S T A V + V Y + Y P N+
Sbjct: 361 -AYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGG----YDGTSDLATVESYDPVTNT 415
Query: 415 WQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSF 474
WQ R + VA L+G +Y GG D + L E Y W VA +
Sbjct: 416 WQPEVSMGTRRSCLGVAALHGLLYSAGGYDGAS--CLNSAERYDPLTGTWTSVAAMSTRR 473
Query: 475 YSFELIVVQNYLYAV---NSKRMLC----YDPSHNMWLNCASL--KRSDFQEACV----- 520
+ + LYAV +S L Y+P N+W AS+ +RS A +
Sbjct: 474 RYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALY 533
Query: 521 ---FNDEIYCICDIPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQ 577
ND C+ + + Y+P G W ++ + + TH+ +V D L +
Sbjct: 534 VAGGNDGTSCLNSV---ERYSPKAGAWESVAPMNIRRSTHD--LVAMDGWLYAVGGNDGS 588
Query: 578 WKKNRVTVYEYDTREDQWINIGTM 601
N ++ +Y+ R ++W+ M
Sbjct: 589 SSLN--SIEKYNPRTNKWVAASCM 610
Score = 54.7 bits (130), Expect = 3e-07
Identities = 45/167 (26%), Positives = 71/167 (42%), Gaps = 19/167 (11%)
Query: 359 YDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSP---DHDIYLAAQPRKDLWVYKPAQNSW 415
YDP +G ++ + T + + T + D +LA + Y+P N W
Sbjct: 456 YDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK-----YEPQVNVW 510
Query: 416 QQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFY 475
+A L R VA L G +Y+ GG D + L VE YS + W VAP+
Sbjct: 511 SPVASMLSRRSSAGVAVLEGALYVAGGNDGTS--CLNSVERYSPKAGAWESVAPMNIRRS 568
Query: 476 SFELIVVQNYLYAVNS-------KRMLCYDPSHNMWL--NCASLKRS 513
+ +L+ + +LYAV + Y+P N W+ +C +RS
Sbjct: 569 THDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRS 615
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 144 bits (362), Expect = 4e-34
Identities = 143/593 (24%), Positives = 236/593 (39%), Gaps = 116/593 (19%)
Query: 35 TGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACP 94
T E + H+ +++++ + LCDV ++ G R +R VL++
Sbjct: 146 TSDEFFQALNHAEQTFKKMENYLRHKQLCDV---ILVAGD-----RRIPAHRLVLSSVSD 197
Query: 95 YFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLE 154
YF +MFT + E++Q + M V+ S L+ Y YTGR+ L E N++ L + + +LQL
Sbjct: 198 YFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLS 257
Query: 155 YVREACASFLARRLDLTNCTAILKFADA---FDHHKLRSQAQSYIAHNFKQLSRMGSIRE 211
V EAC FL ++L +NC I FADA D HK +AHN+ M IR
Sbjct: 258 QVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK--------VAHNYTMEHFMEVIRN 309
Query: 212 ETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRW---- 267
+ L +++ +L D ++I +E T+ + + W+ ++R +++ +R
Sbjct: 310 QEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLA 369
Query: 268 ----------------------------MHFTEEDQDYLEGLLTKP-------IVKKYCL 292
H E + L+ TKP + +
Sbjct: 370 PQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGM 429
Query: 293 DVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHP 352
D +GA + DL PV N + + G+ + ++
Sbjct: 430 DSTKGATSIEKYDLRTNMWTPVANMNGRR--------------LQFGVAVLDDKLYVVGG 475
Query: 353 RDPFL------CYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLW 406
RD CY+P + MP P+++ H V AV P + A D W
Sbjct: 476 RDGLKTLNTVECYNPKTKTWSVMP-PMSTHRHGLGV---AVLEGP-----MYAVGGHDGW 526
Query: 407 VY-------KPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSV 459
Y P W +A R + VA L+G +Y +GGRD + LK VEC+
Sbjct: 527 SYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS--CLKSVECFDP 584
Query: 460 QRNQWALVAPVPHSFYSFELIVVQNYLYAV----------NSKRMLC---YDPSHNMWLN 506
N+W L A + + LYA+ S+ C YDP +MW
Sbjct: 585 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 644
Query: 507 CASLKRS-DFQEACVFNDEIYCI------CDIPVMKVYNPARGEWRRISNIPL 552
AS+ S D C+ D++Y + + ++ Y+P EW +++ + L
Sbjct: 645 VASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCL 697
Score = 60.5 bits (145), Expect = 5e-09
Identities = 53/214 (24%), Positives = 85/214 (39%), Gaps = 26/214 (12%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALV 467
Y P +W + R G+ VA L G +Y +GG D + L VE + Q QW V
Sbjct: 488 YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS--YLNTVERWDPQARQWNFV 545
Query: 468 APVPHSFYSFELIVVQNYLYAVNS-------KRMLCYDPSHNMWLNCASL-KRSDFQEAC 519
A + + + V+ LYAV K + C+DP N W CA + KR
Sbjct: 546 ATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVT 605
Query: 520 VFNDEIYCI--CDIPVMKV----------YNPARGEWRRISNIPLDSETHNYQIVNHDQK 567
+N +Y I D P + Y+P W ++++ + + ++ K
Sbjct: 606 TWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLG--DK 663
Query: 568 LLLITSTTPQWKKNRVTVYEYDTREDQWINIGTM 601
L + Q N TV YD + ++W + +
Sbjct: 664 LYAVGGYDGQAYLN--TVEAYDPQTNEWTQVAPL 695
Score = 51.6 bits (122), Expect = 2e-06
Identities = 61/262 (23%), Positives = 108/262 (41%), Gaps = 38/262 (14%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVK-LKEVECYSVQRNQWAL 466
Y N W +A+ R VA L+ +Y++GGRD G+K L VECY+ + W++
Sbjct: 441 YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD---GLKTLNTVECYNPKTKTWSV 497
Query: 467 VAPVPHSFYSFELIVVQNYLYAVNSKRMLCY-------DPSHNMWLNCASLK--RSDFQE 517
+ P+ + + V++ +YAV Y DP W A++ RS
Sbjct: 498 MPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGV 557
Query: 518 ACVFNDEIYCI------CDIPVMKVYNPARGEWRRISNIP-----LDSETHN---YQIVN 563
A V + ++Y + + ++ ++P +W + + + T N Y I
Sbjct: 558 A-VLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG 616
Query: 564 HDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICLCA-RVYPSC 622
HD +TS V YD + D W + +M + D+ +CL ++Y
Sbjct: 617 HDAPASNLTSRLSD------CVERYDPKTDMWTAVASM--SISRDAVGVCLLGDKLYAVG 668
Query: 623 LEPGQSFITEEDDARSESSTEW 644
GQ+++ +A + EW
Sbjct: 669 GYDGQAYLNTV-EAYDPQTNEW 689
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 144 bits (362), Expect = 4e-34
Identities = 143/593 (24%), Positives = 236/593 (39%), Gaps = 116/593 (19%)
Query: 35 TGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACP 94
T E + H+ +++++ + LCDV ++ G R +R VL++
Sbjct: 192 TSDEFFQALNHAEQTFKKMENYLRHKQLCDV---ILVAGD-----RRIPAHRLVLSSVSD 243
Query: 95 YFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLE 154
YF +MFT + E++Q + M V+ S L+ Y YTGR+ L E N++ L + + +LQL
Sbjct: 244 YFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLS 303
Query: 155 YVREACASFLARRLDLTNCTAILKFADA---FDHHKLRSQAQSYIAHNFKQLSRMGSIRE 211
V EAC FL ++L +NC I FADA D HK +AHN+ M IR
Sbjct: 304 QVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK--------VAHNYTMEHFMEVIRN 355
Query: 212 ETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRW---- 267
+ L +++ +L D ++I +E T+ + + W+ ++R +++ +R
Sbjct: 356 QEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLA 415
Query: 268 ----------------------------MHFTEEDQDYLEGLLTKP-------IVKKYCL 292
H E + L+ TKP + +
Sbjct: 416 PQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGM 475
Query: 293 DVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHP 352
D +GA + DL PV N + + G+ + ++
Sbjct: 476 DSTKGATSIEKYDLRTNMWTPVANMNGRR--------------LQFGVAVLDDKLYVVGG 521
Query: 353 RDPFL------CYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLW 406
RD CY+P + MP P+++ H V AV P + A D W
Sbjct: 522 RDGLKTLNTVECYNPKTKTWSVMP-PMSTHRHGLGV---AVLEGP-----MYAVGGHDGW 572
Query: 407 VY-------KPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSV 459
Y P W +A R + VA L+G +Y +GGRD + LK VEC+
Sbjct: 573 SYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS--CLKSVECFDP 630
Query: 460 QRNQWALVAPVPHSFYSFELIVVQNYLYAV----------NSKRMLC---YDPSHNMWLN 506
N+W L A + + LYA+ S+ C YDP +MW
Sbjct: 631 HTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTA 690
Query: 507 CASLKRS-DFQEACVFNDEIYCI------CDIPVMKVYNPARGEWRRISNIPL 552
AS+ S D C+ D++Y + + ++ Y+P EW +++ + L
Sbjct: 691 VASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCL 743
Score = 60.5 bits (145), Expect = 5e-09
Identities = 53/214 (24%), Positives = 85/214 (39%), Gaps = 26/214 (12%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALV 467
Y P +W + R G+ VA L G +Y +GG D + L VE + Q QW V
Sbjct: 534 YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS--YLNTVERWDPQARQWNFV 591
Query: 468 APVPHSFYSFELIVVQNYLYAVNS-------KRMLCYDPSHNMWLNCASL-KRSDFQEAC 519
A + + + V+ LYAV K + C+DP N W CA + KR
Sbjct: 592 ATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVT 651
Query: 520 VFNDEIYCI--CDIPVMKV----------YNPARGEWRRISNIPLDSETHNYQIVNHDQK 567
+N +Y I D P + Y+P W ++++ + + ++ K
Sbjct: 652 TWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLG--DK 709
Query: 568 LLLITSTTPQWKKNRVTVYEYDTREDQWINIGTM 601
L + Q N TV YD + ++W + +
Sbjct: 710 LYAVGGYDGQAYLN--TVEAYDPQTNEWTQVAPL 741
Score = 51.6 bits (122), Expect = 2e-06
Identities = 61/262 (23%), Positives = 108/262 (41%), Gaps = 38/262 (14%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVK-LKEVECYSVQRNQWAL 466
Y N W +A+ R VA L+ +Y++GGRD G+K L VECY+ + W++
Sbjct: 487 YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD---GLKTLNTVECYNPKTKTWSV 543
Query: 467 VAPVPHSFYSFELIVVQNYLYAVNSKRMLCY-------DPSHNMWLNCASLK--RSDFQE 517
+ P+ + + V++ +YAV Y DP W A++ RS
Sbjct: 544 MPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGV 603
Query: 518 ACVFNDEIYCI------CDIPVMKVYNPARGEWRRISNIP-----LDSETHN---YQIVN 563
A V + ++Y + + ++ ++P +W + + + T N Y I
Sbjct: 604 A-VLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG 662
Query: 564 HDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICLCA-RVYPSC 622
HD +TS V YD + D W + +M + D+ +CL ++Y
Sbjct: 663 HDAPASNLTSRLSD------CVERYDPKTDMWTAVASM--SISRDAVGVCLLGDKLYAVG 714
Query: 623 LEPGQSFITEEDDARSESSTEW 644
GQ+++ +A + EW
Sbjct: 715 GYDGQAYLNTV-EAYDPQTNEW 735
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 142 bits (359), Expect = 8e-34
Identities = 125/467 (26%), Positives = 205/467 (43%), Gaps = 49/467 (10%)
Query: 53 LKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASV 112
L FY+ LCDVT++V GS +L SC++ VLA PYF++MF M E++Q +
Sbjct: 57 LLRFYENGELCDVTLKV---GS-----KLISCHKLVLACVIPYFRAMFLSEMAEAKQTLI 108
Query: 113 TMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTN 172
+ D D ++ E LV + Y+ R++L+ NVQ L A+ +LQ+E V AC ++ +N
Sbjct: 109 EIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSN 168
Query: 173 CTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLD 232
C A+ FA++ + L A Y +F ++ + E ++ L +L L+
Sbjct: 169 CLAVRAFAESHNRIDLMDMADQYACDHFTEV-----VECEDFVSVSPQHLHKLLSSSDLN 223
Query: 233 IESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKY-- 290
IE+E+ V + A++WL A + E VR D+L G++ K + K
Sbjct: 224 IENEKQVYNAAIKWLLANPQHHSKWLDETLAQVR---LPLLPVDFLMGVVAKEQIVKQNL 280
Query: 291 -CLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFF 349
C D+++ A L+ S VP+ S ++ P++ V
Sbjct: 281 KCRDLLDEARNYH----LHLSSRAVPDFEYSIRTT----------PRKHTAGVLFCVGGR 326
Query: 350 GHPRDPFL---CYDPYSGDIYTMPSPLTSFAHTKTVT-SSAVCVSPDHDIYLAAQPRKDL 405
G DPF CY + P + H ++ V HD + +
Sbjct: 327 GGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHD---GNEHLGSM 383
Query: 406 WVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWA 465
++ P N W A R G+ +A L G IY +GG D T +VE Y ++ +QW+
Sbjct: 384 EMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT--CFNDVERYDIESDQWS 441
Query: 466 LVAPVPHSFYSFELIVVQNYLYAVNSKRMLC-------YDPSHNMWL 505
VAP+ + + N++YAV + YDP + W+
Sbjct: 442 TVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWI 488
Score = 38.9 bits (89), Expect = 0.016
Identities = 27/104 (25%), Positives = 44/104 (42%), Gaps = 9/104 (8%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALV 467
Y P + W ++ + R G V+ L+G +Y++GG D L VE Y + N+W V
Sbjct: 480 YDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFD--DNSPLSSVERYDPRSNKWDYV 537
Query: 468 APVPHSFYSFELIVVQNYLYAVNS-------KRMLCYDPSHNMW 504
A + + V ++AV + +DP N W
Sbjct: 538 AALTTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRW 581
Score = 38.5 bits (88), Expect = 0.021
Identities = 43/186 (23%), Positives = 73/186 (39%), Gaps = 29/186 (15%)
Query: 435 GYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSK-- 492
G ++ +GGR +G + +ECYS+ +N W + +I V+ +YAV
Sbjct: 318 GVLFCVGGRGG-SGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDG 376
Query: 493 -----RMLCYDPSHNMWLNCASL--KRSDFQEACVFN--------DEIYCICDIPVMKVY 537
M +DP N W+ AS+ KR A + D+ C D+ + Y
Sbjct: 377 NEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDV---ERY 433
Query: 538 NPARGEWRRIS--NIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQW 595
+ +W ++ N P + +VNH + + +V YD D+W
Sbjct: 434 DIESDQWSTVAPMNTPRGG-VGSVALVNH-----VYAVGGNDGMASLSSVERYDPHLDKW 487
Query: 596 INIGTM 601
I + M
Sbjct: 488 IEVKEM 493
Score = 38.5 bits (88), Expect = 0.021
Identities = 21/65 (32%), Positives = 30/65 (46%), Gaps = 2/65 (3%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALV 467
Y P N W +A R G+ +A + G I+ +GG + L VE + N+W LV
Sbjct: 527 YDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHN--GNAYLNTVEAFDPVLNRWELV 584
Query: 468 APVPH 472
V H
Sbjct: 585 GSVSH 589
Score = 30.4 bits (67), Expect = 5.7
Identities = 27/114 (23%), Positives = 42/114 (36%), Gaps = 9/114 (7%)
Query: 404 DLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQ 463
D+ Y + W +A R G+ L ++Y +GG D + L VE Y ++
Sbjct: 429 DVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGM--ASLSSVERYDPHLDK 486
Query: 464 WALVAPVPHSFYSFELIVVQNYLYAVNS-------KRMLCYDPSHNMWLNCASL 510
W V + + + LY V + YDP N W A+L
Sbjct: 487 WIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL 540
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 140 bits (352), Expect = 5e-33
Identities = 125/483 (25%), Positives = 206/483 (42%), Gaps = 59/483 (12%)
Query: 44 AHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGG 103
+H +LA L + + DVT+ R F C+R VLAA+ YF++MF+ G
Sbjct: 27 SHPDCVLAHLNTLRKHCMFTDVTLWA--------GDRAFPCHRAVLAASSRYFEAMFSHG 78
Query: 104 MYESQQASVTMHD-VDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACAS 162
+ ES+ +V D + E E+L+D+ Y+ R++++E N + L A DMLQ VR+A A
Sbjct: 79 LRESRDDTVNFQDNLHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAE 138
Query: 163 FLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNF---KQLSRMGSIREETLADLTL 219
FL + L +NC ++ +DA +L + +F +Q S+ ++TL DL
Sbjct: 139 FLEKNLFPSNCLGMMLLSDAHQCRRLYEFSWRMCLVHFETVRQSEDFNSLSKDTLLDL-- 196
Query: 220 AQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTE---EDQD 276
+ D L+ E ER V +QW++ + R E+ + VR ++
Sbjct: 197 ------ISSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAV 250
Query: 277 YLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQ 336
E LL K +D AL+ + L +V P + + L+ +
Sbjct: 251 SSEALLMADERTKLIMD---EALRCKTRILQNDGVVTSPCARPRKAGHTLLILGGQT--- 304
Query: 337 RLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIY 396
MC K + H + P + +PSP F+ + V +
Sbjct: 305 --FMCDK--IYQVDHKAKEII---PKA----DLPSPRKEFSASAIGCKVYVTGGRGSENG 353
Query: 397 LAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITG-------V 449
++ KD+WVY W + A L+ R G A L +Y++GG + G V
Sbjct: 354 VS----KDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSV 409
Query: 450 KLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNS--------KRMLCYDPSH 501
LK+VE Y N+W +VAP+ + ++ + L+ ++ CYDPS
Sbjct: 410 SLKQVEKYDPGANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSE 469
Query: 502 NMW 504
N W
Sbjct: 470 NRW 472
Score = 43.1 bits (100), Expect = 8e-04
Identities = 37/156 (23%), Positives = 58/156 (37%), Gaps = 12/156 (7%)
Query: 359 YDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQL 418
YDP + + M +PL V S+ + + + + Y P++N W
Sbjct: 417 YDP-GANKWMMVAPLRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCYDPSENRWTIK 475
Query: 419 ADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFE 478
A+ A L I+I+GG T +C + NQW + + S
Sbjct: 476 AECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAYRFDC---ETNQWTRIGDMTAKRMSCH 532
Query: 479 LIVVQNYLYAVNS-------KRMLCYDPSHNMWLNC 507
+ N LY V K + CYDP+ + W NC
Sbjct: 533 ALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW-NC 567
Score = 30.0 bits (66), Expect = 7.4
Identities = 29/135 (21%), Positives = 50/135 (37%), Gaps = 13/135 (9%)
Query: 358 CYDPYSGDIYTM----PSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQN 413
CYDP S + +T+ P P + + S + D + A+ R D N
Sbjct: 464 CYDP-SENRWTIKAECPQPWR-YTAAAVLGSQIFIMGGDTEFTAASAYRFDC-----ETN 516
Query: 414 SWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHS 473
W ++ D R +Y++GG + K ++CY + W + VP+S
Sbjct: 517 QWTRIGDMTAKRMSCHALASGNKLYVVGGY--FGTQRCKTLDCYDPTSDTWNCITTVPYS 574
Query: 474 FYSFELIVVQNYLYA 488
+ +L A
Sbjct: 575 LIPTAFVSTWKHLPA 589
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 138 bits (348), Expect = 1e-32
Identities = 136/545 (24%), Positives = 218/545 (40%), Gaps = 109/545 (20%)
Query: 83 SCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQ 142
SC R VL++ YF +MFT + E++Q + M V+ S L+ Y YTGR+ L E N++
Sbjct: 172 SC-RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIE 230
Query: 143 RLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADA---FDHHKLRSQAQSYIAHN 199
L + + +LQL V EAC FL ++L +NC I FADA D HK +AHN
Sbjct: 231 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHK--------VAHN 282
Query: 200 FKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAA 259
+ M IR + L +++ +L D ++I +E T+ + + W+ ++R +
Sbjct: 283 YTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLS 342
Query: 260 EVFKCVRW--------------------------------MHFTEEDQDYLEGLLTKP-- 285
++ +R H E + L+ TKP
Sbjct: 343 KLLAYIRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRK 402
Query: 286 -----IVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGM 340
+ +D +GA + DL PV N + + G+
Sbjct: 403 STVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRR--------------LQFGV 448
Query: 341 CAKEMVIFFGHPRDPFL------CYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHD 394
+ ++ RD CY+P + MP P+++ H V AV P
Sbjct: 449 AVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMP-PMSTHRHGLGV---AVLEGP--- 501
Query: 395 IYLAAQPRKDLWVY-------KPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPIT 447
+ A D W Y P W +A R + VA L+G +Y +GGRD +
Sbjct: 502 --MYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSS 559
Query: 448 GVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAV----------NSKRMLC- 496
LK VEC+ N+W L A + + LYA+ S+ C
Sbjct: 560 --CLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCV 617
Query: 497 --YDPSHNMWLNCASLKRS-DFQEACVFNDEIYCI------CDIPVMKVYNPARGEWRRI 547
YDP +MW AS+ S D C+ D++Y + + ++ Y+P EW ++
Sbjct: 618 ERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQV 677
Query: 548 SNIPL 552
+ + L
Sbjct: 678 APLCL 682
Score = 60.5 bits (145), Expect = 5e-09
Identities = 53/214 (24%), Positives = 85/214 (39%), Gaps = 26/214 (12%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALV 467
Y P +W + R G+ VA L G +Y +GG D + L VE + Q QW V
Sbjct: 473 YNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWS--YLNTVERWDPQARQWNFV 530
Query: 468 APVPHSFYSFELIVVQNYLYAVNS-------KRMLCYDPSHNMWLNCASL-KRSDFQEAC 519
A + + + V+ LYAV K + C+DP N W CA + KR
Sbjct: 531 ATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVT 590
Query: 520 VFNDEIYCI--CDIPVMKV----------YNPARGEWRRISNIPLDSETHNYQIVNHDQK 567
+N +Y I D P + Y+P W ++++ + + ++ K
Sbjct: 591 TWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLG--DK 648
Query: 568 LLLITSTTPQWKKNRVTVYEYDTREDQWINIGTM 601
L + Q N TV YD + ++W + +
Sbjct: 649 LYAVGGYDGQAYLN--TVEAYDPQTNEWTQVAPL 680
Score = 51.6 bits (122), Expect = 2e-06
Identities = 61/262 (23%), Positives = 108/262 (41%), Gaps = 38/262 (14%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVK-LKEVECYSVQRNQWAL 466
Y N W +A+ R VA L+ +Y++GGRD G+K L VECY+ + W++
Sbjct: 426 YDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRD---GLKTLNTVECYNPKTKTWSV 482
Query: 467 VAPVPHSFYSFELIVVQNYLYAVNSKRMLCY-------DPSHNMWLNCASLK--RSDFQE 517
+ P+ + + V++ +YAV Y DP W A++ RS
Sbjct: 483 MPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGV 542
Query: 518 ACVFNDEIYCI------CDIPVMKVYNPARGEWRRISNIP-----LDSETHN---YQIVN 563
A V + ++Y + + ++ ++P +W + + + T N Y I
Sbjct: 543 A-VLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGG 601
Query: 564 HDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICLCA-RVYPSC 622
HD +TS V YD + D W + +M + D+ +CL ++Y
Sbjct: 602 HDAPASNLTSRLSD------CVERYDPKTDMWTAVASM--SISRDAVGVCLLGDKLYAVG 653
Query: 623 LEPGQSFITEEDDARSESSTEW 644
GQ+++ +A + EW
Sbjct: 654 GYDGQAYLNTV-EAYDPQTNEW 674
>gi|42741669 kelch repeat and BTB (POZ) domain containing 10 [Homo
sapiens]
Length = 606
Score = 138 bits (348), Expect = 1e-32
Identities = 137/619 (22%), Positives = 263/619 (42%), Gaps = 67/619 (10%)
Query: 38 EELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFK 97
EEL+ S L LK D + D T++ + C+R +L+A PYF+
Sbjct: 9 EELR-LYQSTLLQDGLKDLLDEKKFIDCTLKA--------GDKSLPCHRLILSACSPYFR 59
Query: 98 SMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVR 157
F + E+++ V + +VD ++++ Y Y+ + L++ NVQ ++A + Q+ V
Sbjct: 60 EYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVF 119
Query: 158 EACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADL 217
C S+L +RL NC AIL+ D +L A+ +++ F Q+ +EE L
Sbjct: 120 TVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQI-----CKEEDFMQL 174
Query: 218 TLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEE-DQD 276
+ +L++V+ DSL++E E V ++W+ + R + +EVF C+R+ TE+ +D
Sbjct: 175 SPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKD 234
Query: 277 YLEG---LLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAEN 333
++E + + P ++K + V++ A + + + + L+ N
Sbjct: 235 HVEKDDIIKSNPDLQKK-IKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLN 293
Query: 334 PPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDH 393
R GM K++++ + YDP + Y LT+ A S++ V+ +
Sbjct: 294 DIPRHGMFVKDLILLVND--TAAVAYDPTENECY-----LTALAEQIPRNHSSI-VTQQN 345
Query: 394 DIYLAA-----QPRKD------LWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGG 442
IY+ + KD + + W L R + ++ IY++ G
Sbjct: 346 QIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAG 405
Query: 443 RDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSK--------RM 494
+D T L V CY +W V +P Y +I + +Y + K R+
Sbjct: 406 KDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRV 465
Query: 495 LCYDPSHNMWLNCASLK--RSDFQEACVFNDEIYCICDI------PVMKVYNPARGEWRR 546
++P W + A +K RS F A V +I + ++ ++ +W
Sbjct: 466 FIFNPKKGDWKDLAPMKIPRSMFGVA-VHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDV 524
Query: 547 ISNIPLDSETHNYQIVNHDQKL------LLITSTTPQWKKNRVT-VYEYDTREDQWINIG 599
++ P E + +V+ L +I + ++ V +++Y+ + +W
Sbjct: 525 MTEFP--QERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAG-- 580
Query: 600 TMLGLLQFDSGFICLCARV 618
ML +++ SG CL R+
Sbjct: 581 -MLKEIRYASGASCLATRL 598
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 137 bits (344), Expect = 4e-32
Identities = 136/593 (22%), Positives = 246/593 (41%), Gaps = 62/593 (10%)
Query: 27 KPSVSAFFTGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNR 86
K + FFT HS+ +L LLCDVT+ PG G +F +R
Sbjct: 20 KAGTTRFFTS------NTHSSVVLQGFDQLRIEGLLCDVTL---VPGDGD---EIFPVHR 67
Query: 87 NVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYA 146
++A+A YFK+MFTGGM E + +H V+ + ++D+ YT ++SL+ N+Q
Sbjct: 68 AMMASASDYFKAMFTGGMKEQDLMCIKLHGVNKVGLKKIIDFIYTAKLSLNMDNLQDTLE 127
Query: 147 ASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRM 206
A+ LQ+ V + C FL + L NC + + A+ ++ ++ ++I NF L
Sbjct: 128 AASFLQILPVLDFCKVFLISGVSLDNCVEVGRIANTYNLIEVDKYVNNFILKNFPALLST 187
Query: 207 GSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVR 266
G + L +L VL +SL +E + A +WL R AA++ K +R
Sbjct: 188 GEFLK-----LPFERLAFVLSSNSLKHCTELELFKAACRWLR-LEDPRMDYAAKLMKNIR 241
Query: 267 WMHFTEEDQDYLEGLLTKPIVK--KYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSS 324
+ T QD + + T ++ C++++ A Y + Y V + ++ S S
Sbjct: 242 FPLMT--PQDLINYVQTVDFMRTDNTCVNLLLEA--SNYQMMPYMQPVMQSDRTAIRSDS 297
Query: 325 NSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTM-PSPLTSFAHTKTVT 383
LV+ G+ +++V+ YD + + ++ P + H V
Sbjct: 298 THLVTLG-------GVLRQQLVV-----SKELRMYDERAQEWRSLAPMDAPRYQHGIAVI 345
Query: 384 SSAVCVSPDHDIY--LAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILG 441
+ + V Y ++ + P N W Q+A R ++ L G++Y +G
Sbjct: 346 GNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVG 405
Query: 442 GRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVN-------SKRM 494
GR +L VECY+ + N+W+ VA + Y V +Y +
Sbjct: 406 GRS--AAGELATVECYNPRMNEWSYVAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNEL 463
Query: 495 LCYDPSHNMWLNCASLKR-SDFQEACVFNDEIYCI-----------CDIPVMKVYNPARG 542
+C+DP + W+ A + C D++Y I D+ + Y+P
Sbjct: 464 MCFDPDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLD 523
Query: 543 EWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQW 595
+W I+ + + + + K+ ++ + + V +YD +D+W
Sbjct: 524 QWTPIAAMLRGQS--DVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW 574
Score = 49.7 bits (117), Expect = 9e-06
Identities = 45/200 (22%), Positives = 81/200 (40%), Gaps = 29/200 (14%)
Query: 436 YIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSK--- 492
++ LGG V KE+ Y + +W +AP+ Y + V+ N+LY V +
Sbjct: 299 HLVTLGGVLRQQLVVSKELRMYDERAQEWRSLAPMDAPRYQHGIAVIGNFLYVVGGQSNY 358
Query: 493 ---------RMLCYDPSHNMWLNCASL-KRSDFQEACVFNDEIYCI------CDIPVMKV 536
+ +DP +N W+ ASL ++ F +Y + ++ ++
Sbjct: 359 DTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVEC 418
Query: 537 YNPARGEWRRISNIPLDSETHNYQIVNHDQKLLLIT-STTPQWKKNRVTVYEYDTREDQW 595
YNP EW ++ + SE H L+ I+ T +N + ++ DT D+W
Sbjct: 419 YNPRMNEWSYVAKM---SEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDT--DKW 473
Query: 596 INIGTMLGLLQFDSGFICLC 615
+ M + G C+C
Sbjct: 474 MQKAPMTTV----RGLHCMC 489
Score = 36.2 bits (82), Expect = 0.10
Identities = 28/131 (21%), Positives = 56/131 (42%), Gaps = 17/131 (12%)
Query: 353 RDPFLCYDPYSGDIYTMPSPLTSFA--HTKTVTSSAVCV--------SPDHDIYLAAQPR 402
++ +C+DP + D + +P+T+ H + V + D+D L+ +
Sbjct: 460 QNELMCFDPDT-DKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCE-- 516
Query: 403 KDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRN 462
Y P + W +A L + + VA IY++GG ++ V+ Y +++
Sbjct: 517 ----YYSPTLDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKD 572
Query: 463 QWALVAPVPHS 473
+W V +P S
Sbjct: 573 EWHKVFDLPES 583
>gi|24432026 kelch-like [Homo sapiens]
Length = 634
Score = 134 bits (338), Expect = 2e-31
Identities = 137/578 (23%), Positives = 228/578 (39%), Gaps = 55/578 (9%)
Query: 41 KDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMF 100
+ HS ALL L + D+ +L DV + V GR +R +LAA+C YF+ MF
Sbjct: 28 RSAQHSQALLRGLLALRDSGILFDVVLVV--------EGRHIEAHRILLAASCDYFRGMF 79
Query: 101 TGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREAC 160
GG+ E +Q V +H V + ++ + YT + LS +NVQ A+ LQ+ + C
Sbjct: 80 AGGLKEMEQEEVLIHGVSYNAMCQILHFIYTSELELSLSNVQETLVAACQLQIPEIIHFC 139
Query: 161 ASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLA 220
FL +D N + + A+ FD +L Q +YI NF SR R+ L L
Sbjct: 140 CDFLMSWVDEENILDVYRLAELFDLSRLTEQLDTYILKNFVAFSRTDKYRQ-----LPLE 194
Query: 221 QLLAVLRLDSLDIESERTVCHVAVQW---LEAAAKERGPSAAEVFKCVRWMHFTEEDQDY 277
++ ++L + L++ E V A+ + LE ++ S E K + + F + +
Sbjct: 195 KVYSLLSSNRLEVSCETEVYEGALLYHYSLEQVQADQ-ISLHEPPKLLETVRFPLMEAEV 253
Query: 278 LEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSL-VPVPNSSSSSSSSNSLVSAAENPPQ 336
L+ L K + D + AL + L SL P S P
Sbjct: 254 LQRLHDK-LDPSPLRDTVASALMYHRNESLQPSLQSPQTELRSDFQCVVGFGGIHSTPST 312
Query: 337 RLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIY 396
L AK + G + ++ + +P S + + + D+++
Sbjct: 313 VLSDQAKYLNPLLGE-------WKHFTASL----APRMSNQGIAVLNNFVYLIGGDNNVQ 361
Query: 397 LAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVEC 456
+ W Y P N W Q+ + V + YIY + GRD L VE
Sbjct: 362 -GFRAESRCWRYDPRHNRWFQIQSLQQEHADLSVCVVGRYIYAVAGRDYHN--DLNAVER 418
Query: 457 YSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKR-------MLCYDPSHNMWLNCAS 509
Y N WA VAP+ Y+ ++ +Y +R CYDP N W A
Sbjct: 419 YDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYLKETHCYDPGSNTWHTLAD 478
Query: 510 --LKRSDFQEACVFNDEIYCI----------CDIPVMKVYNPARGEWRRISNIPLDSETH 557
++R+ A + N ++Y I D+ + Y+ G+W + +P
Sbjct: 479 GPVRRAWHGMATLLN-KLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAGHGEP 537
Query: 558 NYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQW 595
++ D ++ ++ + V+ YD +D W
Sbjct: 538 GIAVL--DNRIYVLGGRSHNRGSRTGYVHIYDVEKDCW 573
Score = 55.1 bits (131), Expect = 2e-07
Identities = 46/198 (23%), Positives = 83/198 (41%), Gaps = 26/198 (13%)
Query: 359 YDPYSGD-IYTMPSPLTSFAHTKTVTSSAVCVSPDH--DIYLAAQPRKDLWVYKPAQNSW 415
YDP + Y P +AH + ++ + YL K+ Y P N+W
Sbjct: 419 YDPATNSWAYVAPLKREVYAHAGATLEGKMYITCGRRGEDYL-----KETHCYDPGSNTW 473
Query: 416 QQLADRLLCREGMDVAYLNGYIYILGGRDPITGVK--LKEVECYSVQRNQWALVAPVPHS 473
LAD + R +A L +Y++GG + G + + +V CYS QW+ V P+P
Sbjct: 474 HTLADGPVRRAWHGMATLLNKLYVIGGSNNDAGYRRDVHQVACYSCTSGQWSSVCPLPAG 533
Query: 474 FYSFELIVVQNYLYAVNSKRMLCYDPSHNM-----WLNCASLKRSDFQEACVFNDEI--- 525
+ V+ N +Y + + SHN +++ +++ ++E ++ I
Sbjct: 534 HGEPGIAVLDNRIYVLGGR-------SHNRGSRTGYVHIYDVEKDCWEEGPQLDNSISGL 586
Query: 526 -YCICDIPVMKVYNPARG 542
C+ +P + P RG
Sbjct: 587 AACVLTLPRSLLLEPPRG 604
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 134 bits (337), Expect = 3e-31
Identities = 144/567 (25%), Positives = 244/567 (43%), Gaps = 68/567 (11%)
Query: 61 LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
LLCDVTI S +R VLAA PYF +MFTG M ES+ V + +VD
Sbjct: 58 LLCDVTIVA--------EDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 109
Query: 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
+ +L+DY YT + ++E NVQ L A+ +LQL+ V++ C FL +L NC I FA
Sbjct: 110 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 169
Query: 181 DAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVC 240
D L ++A +Y E+ AD+ L++ + L++ E+
Sbjct: 170 DMHACTDLLNKANTYA--------------EQHFADVVLSE-------EFLNLGIEQVCS 208
Query: 241 HVAVQWLEAAAKERGPSAAEVFKCV-RWM-HFTEEDQDYLEGLLTK---PIV-KKYCLDV 294
++ L +++E+ VF+ V W+ H + Q+++ L+ P++ ++Y +
Sbjct: 209 LISSDKLTISSEEK------VFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQR 262
Query: 295 IEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRD 354
+E ++ L+ + L+ + + K MV+ G
Sbjct: 263 VEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPK 322
Query: 355 PFL---CYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPA 411
CYD + + + + L S + A V + + R + Y P
Sbjct: 323 AIRSVECYD-FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRT-VDSYDPV 380
Query: 412 QNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVP 471
++ W +A+ R + A LNG +Y +GG D TG L VE Y+++ N+W VAP+
Sbjct: 381 KDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG--LSSVEAYNIKSNEWFHVAPMN 438
Query: 472 HSFYSFELIVVQNYLYAVN-----SKRML----CYDPSHNMWLNCASLK-RSDFQEACVF 521
S + VV LYAV S++ L CY+ + N W A + R V
Sbjct: 439 TRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVL 498
Query: 522 NDEIYCI--CDIPVMK----VYNPARGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTT 575
N+ +Y + D P+++ VY+P WR+++++ + VN LL
Sbjct: 499 NNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG----LLYVVGG 554
Query: 576 PQWKKNRVTVYEYDTREDQWINIGTML 602
N +V Y+ D+W + + +
Sbjct: 555 DDGSCNLASVEYYNPTTDKWTVVSSCM 581
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 134 bits (337), Expect = 3e-31
Identities = 144/567 (25%), Positives = 244/567 (43%), Gaps = 68/567 (11%)
Query: 61 LLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAE 120
LLCDVTI S +R VLAA PYF +MFTG M ES+ V + +VD
Sbjct: 54 LLCDVTIVA--------EDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGW 105
Query: 121 SFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFA 180
+ +L+DY YT + ++E NVQ L A+ +LQL+ V++ C FL +L NC I FA
Sbjct: 106 TLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFA 165
Query: 181 DAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVC 240
D L ++A +Y E+ AD+ L++ + L++ E+
Sbjct: 166 DMHACTDLLNKANTYA--------------EQHFADVVLSE-------EFLNLGIEQVCS 204
Query: 241 HVAVQWLEAAAKERGPSAAEVFKCV-RWM-HFTEEDQDYLEGLLTK---PIV-KKYCLDV 294
++ L +++E+ VF+ V W+ H + Q+++ L+ P++ ++Y +
Sbjct: 205 LISSDKLTISSEEK------VFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQR 258
Query: 295 IEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRD 354
+E ++ L+ + L+ + + K MV+ G
Sbjct: 259 VEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPK 318
Query: 355 PFL---CYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPA 411
CYD + + + + L S + A V + + R + Y P
Sbjct: 319 AIRSVECYD-FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRT-VDSYDPV 376
Query: 412 QNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVP 471
++ W +A+ R + A LNG +Y +GG D TG L VE Y+++ N+W VAP+
Sbjct: 377 KDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG--LSSVEAYNIKSNEWFHVAPMN 434
Query: 472 HSFYSFELIVVQNYLYAVN-----SKRML----CYDPSHNMWLNCASLK-RSDFQEACVF 521
S + VV LYAV S++ L CY+ + N W A + R V
Sbjct: 435 TRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVL 494
Query: 522 NDEIYCI--CDIPVMK----VYNPARGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTT 575
N+ +Y + D P+++ VY+P WR+++++ + VN LL
Sbjct: 495 NNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNG----LLYVVGG 550
Query: 576 PQWKKNRVTVYEYDTREDQWINIGTML 602
N +V Y+ D+W + + +
Sbjct: 551 DDGSCNLASVEYYNPTTDKWTVVSSCM 577
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 134 bits (336), Expect = 4e-31
Identities = 142/598 (23%), Positives = 241/598 (40%), Gaps = 94/598 (15%)
Query: 45 HSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGM 104
HS LL L LCD+ + V G ++ + ++ VLA+ PYFK+MFTG +
Sbjct: 17 HSEQLLQGLNLLRQHHELCDIILRV-------GDVKIHA-HKVVLASVSPYFKAMFTGNL 68
Query: 105 YESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFL 164
E + + V +D + + +V+Y YTG V +S+ V+ L A+++LQ++ V + C +FL
Sbjct: 69 SEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFL 128
Query: 165 ARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLA 224
+LD NC I +FA+ + L A YI NF+ + + E +LT A L
Sbjct: 129 ESQLDPGNCIGISRFAETYGCRDLYLAATKYICQNFEAV-----CQTEEFFELTHADLDE 183
Query: 225 VLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTK 284
++ D L++ +E TV + W++ +ER A++ VR
Sbjct: 184 IVSNDCLNVATEETVFYALESWIKYDVQERQKYLAQLLNSVR-----------------L 226
Query: 285 PIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLG----- 339
P+ L +++ LY++ + + + N + P RL
Sbjct: 227 PL------------LSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFMPEHRLSHQTVL 274
Query: 340 ----MCAKEMVIFFGHPRDPFLCYDPY-----SGDIYTMPSPLTSFAHTKTVTSSAVCVS 390
CA +++ G F C D D + +PL + +CV
Sbjct: 275 MTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRY-----EFGICVL 329
Query: 391 PDHDIY----LAAQPRKDLWVYK---------PAQNSWQQLADRLLCREGMDVAYLNGYI 437
D +Y +A R + + K P N+W L R + V L G +
Sbjct: 330 -DQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGEL 388
Query: 438 YILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAV------NS 491
Y LGG D + L+ VE Y + +W VAP+ + F V+ +YA+ +
Sbjct: 389 YALGGYDGQS--YLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHM 446
Query: 492 KRMLCYDPSHNMWLNCASL--KRSDFQEACVFNDEIYC-----ICDIPVMKVYNPARGEW 544
+ YDPS + W AS+ KR F + + + ++ Y+P + +W
Sbjct: 447 NSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQW 506
Query: 545 RRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTML 602
P+ D L ++ + N TV +YD D W++ M+
Sbjct: 507 TVCR--PMKEPRTGVGAAVIDNYLYVVGGHSGSSYLN--TVQKYDPISDTWLDSAGMI 560
Score = 56.6 bits (135), Expect = 7e-08
Identities = 34/130 (26%), Positives = 57/130 (43%), Gaps = 23/130 (17%)
Query: 408 YKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALV 467
Y P+++SW+ +A R V + G+I+++GG + ++ L +E Y +NQW +
Sbjct: 452 YDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS--HLSSIERYDPHQNQWTVC 509
Query: 468 APVPHSFYSFELIVVQNYLYAVNS-------KRMLCYDPSHNMWLNCASLKRSDFQEACV 520
P+ V+ NYLY V + YDP + WL+ A +
Sbjct: 510 RPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGM---------- 559
Query: 521 FNDEIYCICD 530
IYC C+
Sbjct: 560 ----IYCRCN 565
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 132 bits (332), Expect = 1e-30
Identities = 132/582 (22%), Positives = 232/582 (39%), Gaps = 103/582 (17%)
Query: 37 PEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYF 96
P+++ H+ ++L + S + LCDVT+ V F +R VLAA YF
Sbjct: 7 PKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKD--------FPAHRIVLAACSDYF 58
Query: 97 KSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYV 156
+MFT + E + V + + A + E+L+D+ YT V ++ NVQ L A+ +LQL+ V
Sbjct: 59 CAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGV 118
Query: 157 REACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLAD 216
++AC FL +LD +NC I FA+ + L A+ + +F ++ ++ E
Sbjct: 119 KQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEV-----VQHEEFIL 173
Query: 217 LTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQD 276
L+ ++ +++ D + ++SE V + W++ A KER S + + VR T
Sbjct: 174 LSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLT----- 228
Query: 277 YLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQ 336
+Y DVI+ +R L + LV + + L S + P
Sbjct: 229 -----------PRYITDVIDAEPFIRC-SLQCRDLV---DEAKKFHLRPELRSQMQGPRT 273
Query: 337 RLGMCAKEMVIFFG------HPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVT------- 383
R + A E+++ G P D YDP + + +PS + +V+
Sbjct: 274 RARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYV 333
Query: 384 ----------SSAVCV--SPDHD------------------------IYLA-----AQPR 402
SS C+ + D D IY++ ++
Sbjct: 334 IGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRH 393
Query: 403 KDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRN 462
+ Y P + W L D REG + +G IY LGG D + L VE Y
Sbjct: 394 TSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLN--ILNSVEKYDPHTG 451
Query: 463 QWALVAPVPHSFYSFELIVVQNYLYAVNS-------KRMLCYDPSHNMWLNCASLKRSD- 514
W V P+ + ++ +++Y V + Y+ + W S+
Sbjct: 452 HWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRC 511
Query: 515 FQEACVFNDEIYCICD------IPVMKVYNPARGEWRRISNI 550
+ A V +Y I + ++ Y+P W ++++
Sbjct: 512 YVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSM 553
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 129 bits (325), Expect = 7e-30
Identities = 132/585 (22%), Positives = 241/585 (41%), Gaps = 57/585 (9%)
Query: 36 GPEEL-KDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACP 94
GP + HS+ +L LLCDVT+ PG T F +R ++A+A
Sbjct: 64 GPTRIFTSNTHSSVVLQGFDQLRLEGLLCDVTL---MPGD---TDDAFPVHRVMMASASD 117
Query: 95 YFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLE 154
YFK+MFTGGM E + +H V ++D+ YT ++SL+ N+Q A+ LQ+
Sbjct: 118 YFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEAASFLQIL 177
Query: 155 YVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETL 214
V + C FL + L NC + + A+ ++ ++ S++ NF L G +
Sbjct: 178 PVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTGEFLK--- 234
Query: 215 ADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEED 274
L +L VL +SL +E + +WL + R AA++ K +R+ T
Sbjct: 235 --LPFERLAFVLSSNSLKHCTELELFKATCRWLR-LEEPRMDFAAKLMKNIRFPLMT--P 289
Query: 275 QDYLEGLLTKPIVK--KYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAE 332
Q+ + + T ++ C++++ A Y + Y V + ++ S + LV+
Sbjct: 290 QELINYVQTVDFMRTDNTCVNLLLEA--SNYQMMPYMQPVMQSDRTAIRSDTTHLVTLG- 346
Query: 333 NPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTM-PSPLTSFAHTKTVTSSAVCVSP 391
G+ +++V+ YD + + ++ P + H V + + V
Sbjct: 347 ------GVLRQQLVV-----SKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVG 395
Query: 392 DHDIY--LAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGV 449
Y ++ + P N W Q+A R ++ L GY+Y +GGR+
Sbjct: 396 GQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRN--AAG 453
Query: 450 KLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVN-------SKRMLCYDPSHN 502
+L VECY+ + N+W VA + Y V +Y K ++C+DP +
Sbjct: 454 ELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDTD 513
Query: 503 MWLNCASLKR-SDFQEACVFNDEIYCI-----------CDIPVMKVYNPARGEWRRISNI 550
W+ A + C + +Y I D+ + Y+P +W I+ +
Sbjct: 514 KWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAM 573
Query: 551 PLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQW 595
+ + + K+ ++ + + V +YD +D+W
Sbjct: 574 LRGQS--DVGVAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616
Score = 50.8 bits (120), Expect = 4e-06
Identities = 44/200 (22%), Positives = 82/200 (41%), Gaps = 29/200 (14%)
Query: 436 YIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSK--- 492
++ LGG V KE+ Y + ++W +AP+ Y + V+ N+LY V +
Sbjct: 341 HLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNY 400
Query: 493 ---------RMLCYDPSHNMWLNCASL-KRSDFQEACVFNDEIYCI------CDIPVMKV 536
+ +DP +N W+ ASL ++ F +Y + ++P ++
Sbjct: 401 DTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVEC 460
Query: 537 YNPARGEWRRISNIPLDSETH-NYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQW 595
YNP EW ++ + SE H + + + + T + + ++ DT D+W
Sbjct: 461 YNPRTNEWTYVAKM---SEPHYGHAGTVYGGVMYISGGITHDTFQKELMCFDPDT--DKW 515
Query: 596 INIGTMLGLLQFDSGFICLC 615
I M + G C+C
Sbjct: 516 IQKAPMTTV----RGLHCMC 531
Score = 35.0 bits (79), Expect = 0.23
Identities = 33/143 (23%), Positives = 58/143 (40%), Gaps = 21/143 (14%)
Query: 345 MVIFFGHPRDPF----LCYDPYSGDIYTMPSPLTSFA--HTKTVTSSAVCV--------S 390
M I G D F +C+DP + D + +P+T+ H + V +
Sbjct: 490 MYISGGITHDTFQKELMCFDPDT-DKWIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGT 548
Query: 391 PDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVK 450
D+D L+ + Y P + W +A L + + VA IY++GG
Sbjct: 549 SDYDDVLSCE------YYSPILDQWTPIAAMLRGQSDVGVAVFENKIYVVGGYSWNNRCM 602
Query: 451 LKEVECYSVQRNQWALVAPVPHS 473
++ V+ Y +++W V +P S
Sbjct: 603 VEIVQKYDPDKDEWHKVFDLPES 625
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 129 bits (324), Expect = 9e-30
Identities = 135/561 (24%), Positives = 227/561 (40%), Gaps = 64/561 (11%)
Query: 62 LCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAES 121
L DVT+ V GR C+R +LA + PYF +MF G ES A V + DV+
Sbjct: 14 LADVTLLV--------GGRELPCHRGLLALSSPYFHAMFAGDFAESFSARVELRDVEPAV 65
Query: 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFAD 181
LVD+ YTGR+++++ NV+ L + L V++ C +L ++LD NC I +F +
Sbjct: 66 VGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANCLGICEFGE 125
Query: 182 AFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCH 241
+ ++A +++ NF+ ++ RE+ L +L+ L D L ++ E++
Sbjct: 126 QQGLLGVAAKAWAFLRENFEAVA-----REDEFLQLPRERLVTCLAGDLLQVQPEQSRLE 180
Query: 242 VAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLL-TKPIVK-----KYCLDVI 295
++W+ + R E+ V H + ++ LL ++P+++ + L
Sbjct: 181 ALMRWVRHDPQARAAHLPELLSLV---HLDAVPRPCVQQLLASEPLIQESEACRAALSQG 237
Query: 296 EGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDP 355
+ L + LV V + A E P LG A F+
Sbjct: 238 HDGAPLALQQKLEEVLVVVGGQALEEE------EAGEEPTPGLGNFA-----FYNSKAKR 286
Query: 356 FLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSW 415
++ P D + L + + VT + D W + + SW
Sbjct: 287 WMAL-PDFPDYHKWGFSLAALNNNIYVTGGSRGTKTD------TWSTTQAWCFPLKEASW 339
Query: 416 QQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFY 475
+ +A L R A LNG IY++GG T + + EVE Y + W V+P
Sbjct: 340 KPVAPMLKPRTNHASAALNGEIYVIGG----TTLDVVEVESYDPYTDSWTPVSPALKYVS 395
Query: 476 SFELIVVQNYLYAV-------NSKRMLCYDPSHNMWLNCAS---LKRSDFQEACVFNDEI 525
+F + LY V N+ + CY+P + W AS K + E+
Sbjct: 396 NFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGEL 455
Query: 526 YCICD-IPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWK----K 580
Y I D + VY+P W+++ + S N +V L + T +W+
Sbjct: 456 YLIGDNTKKVYVYDPGANLWQKVQS--QHSLHENGALVPLGDALYV---TGGRWQGMEGD 510
Query: 581 NRVTVYEYDTREDQWINIGTM 601
V + YDT D W G +
Sbjct: 511 YHVEMEAYDTVRDTWTRHGAL 531
Score = 45.8 bits (107), Expect = 1e-04
Identities = 30/115 (26%), Positives = 48/115 (41%), Gaps = 6/115 (5%)
Query: 358 CYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQ 417
CY+P + + SP SS C + ++YL K ++VY P N WQ+
Sbjct: 423 CYNPVTDAWSVIASPFLP-----KYLSSPRCAALHGELYLIGDNTKKVYVYDPGANLWQK 477
Query: 418 LADRLLCREGMDVAYLNGYIYILGGR-DPITGVKLKEVECYSVQRNQWALVAPVP 471
+ + E + L +Y+ GGR + G E+E Y R+ W +P
Sbjct: 478 VQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTRHGALP 532
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 123 bits (308), Expect = 6e-28
Identities = 125/533 (23%), Positives = 216/533 (40%), Gaps = 55/533 (10%)
Query: 62 LCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAES 121
LCDVT++V + F ++ VLA++ P FK+MFT G+ E V++ + +
Sbjct: 76 LCDVTLQVKYQDAPAAQ---FMAHKVVLASSSPVFKAMFTNGLREQGMEVVSIEGIHPKV 132
Query: 122 FEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFAD 181
E L+++ YT +S+ E V + + M Q++ V AC+ FL ++LD +N I FA+
Sbjct: 133 MERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNAIGIANFAE 192
Query: 182 AFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCH 241
+L +A+ YI +F +++ ++E +L+ QL+ ++ D L++ E V H
Sbjct: 193 QIGCVELHQRAREYIYMHFGEVA-----KQEEFFNLSHCQLVTLISRDDLNVRCESEVFH 247
Query: 242 VAVQWLEAAAKERGPSAAEVFKCVRWMHFT-----------------EEDQDYL-----E 279
+ W++ ++R + + VR T +DYL E
Sbjct: 248 ACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVKIFEE 307
Query: 280 GLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLG 339
L KP C G L G +SL + + S + L + P L
Sbjct: 308 LTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLAD-LQVPRSGLA 366
Query: 340 MCAKEMVIFF--GHPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSP-DHDIY 396
C +++ G P D + D Y + S +V + + V D IY
Sbjct: 367 GCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIY 426
Query: 397 LAAQP-----RKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKL 451
+ Y+P ++ W +A L R G+ VA LN +Y +GG D +L
Sbjct: 427 AVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGTN--RL 484
Query: 452 KEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNS-------KRMLCYDPSHNMW 504
ECY +RN+W ++ + + V+ N +YA + YD W
Sbjct: 485 NSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVETETW 544
Query: 505 LNCASLK-RSDFQEACVFNDEIYCI------CDIPVMKVYNPARGEWRRISNI 550
A +K R V IY + + ++ Y+P W ++ +
Sbjct: 545 TFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRM 597
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.133 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,838,022
Number of Sequences: 37866
Number of extensions: 1206023
Number of successful extensions: 4268
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 142
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 3406
Number of HSP's gapped (non-prelim): 486
length of query: 684
length of database: 18,247,518
effective HSP length: 109
effective length of query: 575
effective length of database: 14,120,124
effective search space: 8119071300
effective search space used: 8119071300
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.