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Search of human proteins with 10190706
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|10190706 CDC-like kinase 4 [Homo sapiens]
(481 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|10190706 CDC-like kinase 4 [Homo sapiens] 1019 0.0
gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens] 791 0.0
gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens] 791 0.0
gi|47717134 CDC-like kinase 2 [Homo sapiens] 567 e-162
gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens] 514 e-146
gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens] 514 e-146
gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation regul... 206 5e-53
gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulat... 206 5e-53
gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regula... 204 1e-52
gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regula... 204 1e-52
gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regula... 198 1e-50
gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulat... 184 2e-46
gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulat... 182 4e-46
gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulat... 174 2e-43
gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regula... 172 8e-43
gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regula... 172 8e-43
gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regula... 172 8e-43
gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regula... 172 8e-43
gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regula... 172 8e-43
gi|164420691 homeodomain interacting protein kinase 2 isoform 2 ... 166 4e-41
gi|164420685 homeodomain interacting protein kinase 2 isoform 1 ... 166 4e-41
gi|114796630 homeodomain interacting protein kinase 3 isoform 2 ... 158 9e-39
gi|114796624 homeodomain interacting protein kinase 3 isoform 1 ... 158 9e-39
gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens] 154 1e-37
gi|38201640 homeodomain-interacting protein kinase 1 isoform 1 [... 153 3e-37
gi|38201638 homeodomain-interacting protein kinase 1 isoform 2 [... 153 3e-37
gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens] 141 1e-33
gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens] 121 1e-27
gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens] 121 1e-27
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s... 114 3e-25
>gi|10190706 CDC-like kinase 4 [Homo sapiens]
Length = 481
Score = 1019 bits (2634), Expect = 0.0
Identities = 481/481 (100%), Positives = 481/481 (100%)
Query: 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR 60
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR
Sbjct: 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR 60
Query: 61 SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH 120
SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH
Sbjct: 61 SLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRH 120
Query: 121 CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG 180
CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG
Sbjct: 121 CSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHG 180
Query: 181 MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE 240
MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE
Sbjct: 181 MDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFE 240
Query: 241 LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV 300
LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV
Sbjct: 241 LLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYV 300
Query: 301 VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV 360
VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV
Sbjct: 301 VKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDV 360
Query: 361 WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH 420
WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH
Sbjct: 361 WSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEH 420
Query: 421 SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK 480
SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK
Sbjct: 421 SSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKK 480
Query: 481 K 481
K
Sbjct: 481 K 481
>gi|241666392 CDC-like kinase 1 isoform 2 [Homo sapiens]
Length = 526
Score = 791 bits (2044), Expect = 0.0
Identities = 383/484 (79%), Positives = 422/484 (87%), Gaps = 6/484 (1%)
Query: 1 MRHSKRTHCPDWDSRESWGHESYRGS--HKRKRRSHSSTQENRHCKPHHQFKESDCHYLE 58
MRHSKRT+CPDWD ++ W + +R S HKR++RSHSS QEN+ CK +H K D HYLE
Sbjct: 43 MRHSKRTYCPDWDDKD-WDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHS-KMCDSHYLE 100
Query: 59 ARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRK-R 117
+RS+NE+DY RRY+DEYRNDY +G P H RD ES Y+ H SKSS RS RSS K K R
Sbjct: 101 SRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHR 160
Query: 118 NRHCSSHQ-SRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVEC 176
H +SH+ S KSHRRKR+RS+EDDEEGHLICQSGDVL ARYEIVDTLGEGAFGKVVEC
Sbjct: 161 IHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVEC 220
Query: 177 IDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVC 236
IDH G HVAVKIVKNV RY EAARSEIQVLEHLN+TDPNS FRCVQMLEWF+HHGH+C
Sbjct: 221 IDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHIC 280
Query: 237 IVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVK 296
IVFELLGLSTYDFIKEN FLPF++DHIR+MAYQIC+S+NFLH NKLTHTDLKPENILFV+
Sbjct: 281 IVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQ 340
Query: 297 SDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ 356
SDY YN K+KRDERTL N DIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ
Sbjct: 341 SDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ 400
Query: 357 PCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLD 416
PCDVWSIGCILIEYYLGFTVF THDSKEHLAMMERILGP+P+HMIQKTRKRKYFHH++LD
Sbjct: 401 PCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLD 460
Query: 417 WDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 476
WDEHSSAGRYV RRCKPLKEFML D EHE+LFDL+++MLEYDP +RITL EAL+HPFFD
Sbjct: 461 WDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 520
Query: 477 LLKK 480
LLKK
Sbjct: 521 LLKK 524
>gi|67551261 CDC-like kinase 1 isoform 1 [Homo sapiens]
Length = 484
Score = 791 bits (2044), Expect = 0.0
Identities = 383/484 (79%), Positives = 422/484 (87%), Gaps = 6/484 (1%)
Query: 1 MRHSKRTHCPDWDSRESWGHESYRGS--HKRKRRSHSSTQENRHCKPHHQFKESDCHYLE 58
MRHSKRT+CPDWD ++ W + +R S HKR++RSHSS QEN+ CK +H K D HYLE
Sbjct: 1 MRHSKRTYCPDWDDKD-WDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHS-KMCDSHYLE 58
Query: 59 ARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRK-R 117
+RS+NE+DY RRY+DEYRNDY +G P H RD ES Y+ H SKSS RS RSS K K R
Sbjct: 59 SRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHR 118
Query: 118 NRHCSSHQ-SRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVEC 176
H +SH+ S KSHRRKR+RS+EDDEEGHLICQSGDVL ARYEIVDTLGEGAFGKVVEC
Sbjct: 119 IHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVEC 178
Query: 177 IDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVC 236
IDH G HVAVKIVKNV RY EAARSEIQVLEHLN+TDPNS FRCVQMLEWF+HHGH+C
Sbjct: 179 IDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHIC 238
Query: 237 IVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVK 296
IVFELLGLSTYDFIKEN FLPF++DHIR+MAYQIC+S+NFLH NKLTHTDLKPENILFV+
Sbjct: 239 IVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQ 298
Query: 297 SDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ 356
SDY YN K+KRDERTL N DIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ
Sbjct: 299 SDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ 358
Query: 357 PCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLD 416
PCDVWSIGCILIEYYLGFTVF THDSKEHLAMMERILGP+P+HMIQKTRKRKYFHH++LD
Sbjct: 359 PCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLD 418
Query: 417 WDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFD 476
WDEHSSAGRYV RRCKPLKEFML D EHE+LFDL+++MLEYDP +RITL EAL+HPFFD
Sbjct: 419 WDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFD 478
Query: 477 LLKK 480
LLKK
Sbjct: 479 LLKK 482
>gi|47717134 CDC-like kinase 2 [Homo sapiens]
Length = 498
Score = 567 bits (1461), Expect = e-162
Identities = 276/486 (56%), Positives = 353/486 (72%), Gaps = 11/486 (2%)
Query: 1 MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEAR 60
M H +R H + SR S+ E YR ++RRS S + + + + D +++ +R
Sbjct: 1 MPHPRRYHSSERGSRGSY-REHYRSRKHKRRRSRSWSSSSDRTRRR---RREDSYHVRSR 56
Query: 61 SL-----NERDYRDRRYVDEYR-NDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPK 114
S ++R DRRY YR NDY +Y D Y SS RS+RSS +
Sbjct: 57 SSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRR 116
Query: 115 RKRNRHCSSHQ-SRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173
+ R R S SRS SH +R++S+EDD EGHLI GD L+ RYEIV TLGEG FG+V
Sbjct: 117 KHRRRRRRSRTFSRSSSHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRV 176
Query: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233
V+C+DH G VA+KI+KNV +Y+EAAR EI VLE +N DP++ CVQM +WFD+HG
Sbjct: 177 VQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHG 236
Query: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENIL 293
H+CI FELLGLST+DF+K+N++LP+ I +R MA+Q+CQ++ FLH NKLTHTDLKPENIL
Sbjct: 237 HMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENIL 296
Query: 294 FVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALG 353
FV SDY + YN + KRDER++K+T ++VVDFGSAT+D EHHST+VSTRHYRAPEVIL LG
Sbjct: 297 FVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELG 356
Query: 354 WSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHN 413
WSQPCDVWSIGCI+ EYY+GFT+FQTHD++EHLAMMERILGPIP MI+KTRK+KYF+
Sbjct: 357 WSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRG 416
Query: 414 QLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHP 473
+LDWDE++SAGRYVR CKPL+ ++ EEH +LFDL+ MLEY+P +R+TL EALQHP
Sbjct: 417 RLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHP 476
Query: 474 FFDLLK 479
FF L+
Sbjct: 477 FFARLR 482
>gi|194097436 CDC-like kinase 3 isoform a [Homo sapiens]
Length = 638
Score = 514 bits (1324), Expect = e-146
Identities = 260/482 (53%), Positives = 329/482 (68%), Gaps = 26/482 (5%)
Query: 8 HCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLN---- 63
HC + S E + SYR ++RRS+S E R P +E +RS +
Sbjct: 151 HCKRYRSPEPDPYLSYRW---KRRRSYSREHEGRLRYPSR--REPPPRRSRSRSHDRLPY 205
Query: 64 ERDYRDRRYVDEYR---------NDYCEGYVPRHYHRDIESG-YRIHCSKSSVRSRRSSP 113
+R YR+RR D YR DY RH R E G YR R
Sbjct: 206 QRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYR-------TRKHAHHC 258
Query: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173
++R R CSS SRS+ ++ SRS+EDD+EGHL+C+ GD L+ RYEIV LGEG FGKV
Sbjct: 259 HKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKV 318
Query: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233
VEC+DH VA+KI++NVG+YREAAR EI VL+ + D + F CV M +WF+ HG
Sbjct: 319 VECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHG 378
Query: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENIL 293
H+CI FELLG +T++F+KEN+F P+ + H+R MAYQ+C ++ FLH N+LTHTDLKPENIL
Sbjct: 379 HMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENIL 438
Query: 294 FVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALG 353
FV S++ YN +E+++KNT I+V DFGSAT+D EHH+T+V+TRHYR PEVIL LG
Sbjct: 439 FVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELG 498
Query: 354 WSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHN 413
W+QPCDVWSIGCIL EYY GFT+FQTH+++EHL MME+ILGPIP HMI +TRK+KYF+
Sbjct: 499 WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKG 558
Query: 414 QLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHP 473
L WDE+SS GRYV+ CKPLK +ML EH +LFDL+RRMLE+DP QRITL EAL HP
Sbjct: 559 GLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHP 618
Query: 474 FF 475
FF
Sbjct: 619 FF 620
>gi|153791372 CDC-like kinase 3 isoform b [Homo sapiens]
Length = 490
Score = 514 bits (1324), Expect = e-146
Identities = 260/482 (53%), Positives = 329/482 (68%), Gaps = 26/482 (5%)
Query: 8 HCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLN---- 63
HC + S E + SYR ++RRS+S E R P +E +RS +
Sbjct: 3 HCKRYRSPEPDPYLSYRW---KRRRSYSREHEGRLRYPSR--REPPPRRSRSRSHDRLPY 57
Query: 64 ERDYRDRRYVDEYR---------NDYCEGYVPRHYHRDIESG-YRIHCSKSSVRSRRSSP 113
+R YR+RR D YR DY RH R E G YR R
Sbjct: 58 QRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYR-------TRKHAHHC 110
Query: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173
++R R CSS SRS+ ++ SRS+EDD+EGHL+C+ GD L+ RYEIV LGEG FGKV
Sbjct: 111 HKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKV 170
Query: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233
VEC+DH VA+KI++NVG+YREAAR EI VL+ + D + F CV M +WF+ HG
Sbjct: 171 VECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHG 230
Query: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENIL 293
H+CI FELLG +T++F+KEN+F P+ + H+R MAYQ+C ++ FLH N+LTHTDLKPENIL
Sbjct: 231 HMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENIL 290
Query: 294 FVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALG 353
FV S++ YN +E+++KNT I+V DFGSAT+D EHH+T+V+TRHYR PEVIL LG
Sbjct: 291 FVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELG 350
Query: 354 WSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHN 413
W+QPCDVWSIGCIL EYY GFT+FQTH+++EHL MME+ILGPIP HMI +TRK+KYF+
Sbjct: 351 WAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKG 410
Query: 414 QLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHP 473
L WDE+SS GRYV+ CKPLK +ML EH +LFDL+RRMLE+DP QRITL EAL HP
Sbjct: 411 GLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHP 470
Query: 474 FF 475
FF
Sbjct: 471 FF 472
>gi|153281169 dual-specificity tyrosine-(Y)-phosphorylation
regulated kinase 2 isoform 2 [Homo sapiens]
Length = 601
Score = 206 bits (523), Expect = 5e-53
Identities = 119/352 (33%), Positives = 188/352 (53%), Gaps = 39/352 (11%)
Query: 141 DDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREA 200
DD++G + D + RYE++ +G+G+FG+VV+ DH + HVA+K+V+N R+
Sbjct: 204 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 262
Query: 201 ARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQI 260
A EI++LEHL D ++ + MLE F H+C+ FELL ++ Y+ IK+N F F +
Sbjct: 263 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 322
Query: 261 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 320
+R+ A+ I Q ++ LH N++ H DLKPENIL +K+ R + IK
Sbjct: 323 PLVRKFAHSILQCLDALHKNRIIHCDLKPENIL-------------LKQQGR----SGIK 365
Query: 321 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTH 380
V+DFGS+ Y+ + T + +R YRAPEVIL + P D+WS+GCIL E G+ +
Sbjct: 366 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 425
Query: 381 DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQ-----------LDWDEHSSAGRYVRR 429
D + LA M +LG Q ++ +++ K F ++ D + GR R
Sbjct: 426 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRG 485
Query: 430 RCKPLKE-------FMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPF 474
+ + E C D D +++ LE+DP R+T +AL+HP+
Sbjct: 486 KLRGPPESREWGNALKGCDD---PLFLDFLKQCLEWDPAVRMTPGQALRHPW 534
>gi|4503427 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 2 isoform 1 [Homo sapiens]
Length = 528
Score = 206 bits (523), Expect = 5e-53
Identities = 119/352 (33%), Positives = 188/352 (53%), Gaps = 39/352 (11%)
Query: 141 DDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREA 200
DD++G + D + RYE++ +G+G+FG+VV+ DH + HVA+K+V+N R+
Sbjct: 131 DDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVH-QHVALKMVRNEKRFHRQ 189
Query: 201 ARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQI 260
A EI++LEHL D ++ + MLE F H+C+ FELL ++ Y+ IK+N F F +
Sbjct: 190 AAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKNKFQGFSL 249
Query: 261 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 320
+R+ A+ I Q ++ LH N++ H DLKPENIL +K+ R + IK
Sbjct: 250 PLVRKFAHSILQCLDALHKNRIIHCDLKPENIL-------------LKQQGR----SGIK 292
Query: 321 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTH 380
V+DFGS+ Y+ + T + +R YRAPEVIL + P D+WS+GCIL E G+ +
Sbjct: 293 VIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGE 352
Query: 381 DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQ-----------LDWDEHSSAGRYVRR 429
D + LA M +LG Q ++ +++ K F ++ D + GR R
Sbjct: 353 DEGDQLACMIELLGMPSQKLLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRG 412
Query: 430 RCKPLKE-------FMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPF 474
+ + E C D D +++ LE+DP R+T +AL+HP+
Sbjct: 413 KLRGPPESREWGNALKGCDD---PLFLDFLKQCLEWDPAVRMTPGQALRHPW 461
>gi|51702242 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform b [Homo sapiens]
Length = 568
Score = 204 bits (519), Expect = 1e-52
Identities = 123/349 (35%), Positives = 189/349 (54%), Gaps = 33/349 (9%)
Query: 141 DDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREA 200
DD +G I D L RYE++ +G+G+FG+V DH + +VA+K+V+N R+
Sbjct: 171 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 229
Query: 201 ARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQI 260
A EI++LEHL D + MLE F HVC+ FELL + Y+ IK+N F F +
Sbjct: 230 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 289
Query: 261 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 320
+R+ A I QS++ LH NK+ H DLKPENIL +K++ + + K
Sbjct: 290 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------LKHHGR----------SSTK 332
Query: 321 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTH 380
V+DFGS+ ++ + T + +R YRAPE+IL +S P D+WS GCIL E G +F
Sbjct: 333 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 392
Query: 381 DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHN-----------QLDWDEHSSAGRYVR- 428
D + LA M +LG P +++++++ KYF ++ Q D GR R
Sbjct: 393 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 452
Query: 429 -RRCKP-LKEFMLCHDEEHEKLF-DLVRRMLEYDPTQRITLDEALQHPF 474
+R P K++ + LF + ++R L +DP+ R+T +AL+HP+
Sbjct: 453 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 501
>gi|51702240 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 3 isoform a [Homo sapiens]
Length = 588
Score = 204 bits (519), Expect = 1e-52
Identities = 123/349 (35%), Positives = 189/349 (54%), Gaps = 33/349 (9%)
Query: 141 DDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREA 200
DD +G I D L RYE++ +G+G+FG+V DH + +VA+K+V+N R+
Sbjct: 191 DDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLR-QYVALKMVRNEKRFHRQ 249
Query: 201 ARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQI 260
A EI++LEHL D + MLE F HVC+ FELL + Y+ IK+N F F +
Sbjct: 250 AAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSV 309
Query: 261 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 320
+R+ A I QS++ LH NK+ H DLKPENIL +K++ + + K
Sbjct: 310 QLVRKFAQSILQSLDALHKNKIIHCDLKPENIL-------LKHHGR----------SSTK 352
Query: 321 VVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTH 380
V+DFGS+ ++ + T + +R YRAPE+IL +S P D+WS GCIL E G +F
Sbjct: 353 VIDFGSSCFEYQKLYTYIQSRFYRAPEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGE 412
Query: 381 DSKEHLAMMERILGPIPQHMIQKTRKRKYFHHN-----------QLDWDEHSSAGRYVR- 428
D + LA M +LG P +++++++ KYF ++ Q D GR R
Sbjct: 413 DEGDQLACMMELLGMPPPKLLEQSKRAKYFINSKGIPRYCSVTTQADGRVVLVGGRSRRG 472
Query: 429 -RRCKP-LKEFMLCHDEEHEKLF-DLVRRMLEYDPTQRITLDEALQHPF 474
+R P K++ + LF + ++R L +DP+ R+T +AL+HP+
Sbjct: 473 KKRGPPGSKDWGTALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPW 521
>gi|28827774 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 4 [Homo sapiens]
Length = 520
Score = 198 bits (503), Expect = 1e-50
Identities = 108/339 (31%), Positives = 185/339 (54%), Gaps = 20/339 (5%)
Query: 134 KRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKN 193
K S++ DDE G + D + RYE+++T+G+G+FG+V +C+DH + + VA+KI++N
Sbjct: 79 KFSKTSFDDEHGFYLKVLHDHIAYRYEVLETIGKGSFGQVAKCLDHKNNEL-VALKIIRN 137
Query: 194 VGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKEN 253
R+ + A E+++LE L D ++ + V M ++F H CI FELLG++ Y+ +K N
Sbjct: 138 KKRFHQQALMELKILEALRKKDKDNTYNVVHMKDFFYFRNHFCITFELLGINLYELMKNN 197
Query: 254 SFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERT 313
+F F + +R+ + + + L K+ H DLKPENI+ +
Sbjct: 198 NFQGFSLSIVRRFTLSVLKCLQMLSVEKIIHCDLKPENIVLYQKG--------------- 242
Query: 314 LKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLG 373
+KV+DFGS+ Y+ + T + +R YR+PEVIL + D+WS+GCI E Y G
Sbjct: 243 --QASVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYDVAIDMWSLGCITAELYTG 300
Query: 374 FTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKP 433
+ +F + E LA + +LG P IQ +R+ F ++ + ++ + R ++R
Sbjct: 301 YPLFPGENEVEQLACIMEVLGLPPAGFIQTASRRQTFFDSK-GFPKNITNNR-GKKRYPD 358
Query: 434 LKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQH 472
K+ + D +RR L ++P+ R+T D+AL+H
Sbjct: 359 SKDLTMVLKTYDTSFLDFLRRCLVWEPSLRMTPDQALKH 397
>gi|5921999 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform b [Homo sapiens]
Length = 589
Score = 184 bits (467), Expect = 2e-46
Identities = 117/365 (32%), Positives = 186/365 (50%), Gaps = 43/365 (11%)
Query: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173
K++R + S +K ++ + +DD +++ +SG+ RYEI +G+G+FG+V
Sbjct: 67 KKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEIDSLIGKGSFGQV 125
Query: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233
V+ DH + VA+KI+KN + A+ E+++LE +N D + V + F
Sbjct: 126 VKAYDHQTQEL-VAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRN 184
Query: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPEN 291
H+C+VFELL + YD ++ F ++ R++A Q+C ++ FL +L+ H DLKPEN
Sbjct: 185 HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPEN 244
Query: 292 ILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 351
IL K + IK+VDFGS+ + + +R YR+PEV+L
Sbjct: 245 ILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG 287
Query: 352 LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMI-QKTRKRKYF 410
+ D+WS+GCIL+E + G +F + + + + +LG P M+ Q + RKYF
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
Query: 411 HHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEAL 470
E G + RR K L++ DLV RMLEY+P RI+ AL
Sbjct: 348 --------ERLPGGGWTLRRTKELRK-------------DLVLRMLEYEPAARISPLGAL 386
Query: 471 QHPFF 475
QH FF
Sbjct: 387 QHGFF 391
>gi|5922001 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform c [Homo sapiens]
Length = 601
Score = 182 bits (463), Expect = 4e-46
Identities = 118/366 (32%), Positives = 189/366 (51%), Gaps = 33/366 (9%)
Query: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173
K++R + S +K ++ + +DD +++ +SG+ RYEI +G+G+FG+V
Sbjct: 67 KKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEIDSLIGKGSFGQV 125
Query: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233
V+ DH + VA+KI+KN + A+ E+++LE +N D + V + F
Sbjct: 126 VKAYDHQTQEL-VAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRN 184
Query: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPEN 291
H+C+VFELL + YD ++ F ++ R++A Q+C ++ FL +L+ H DLKPEN
Sbjct: 185 HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPEN 244
Query: 292 ILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 351
IL K + IK+VDFGS+ + + +R YR+PEV+L
Sbjct: 245 ILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG 287
Query: 352 LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMI-QKTRKRKYF 410
+ D+WS+GCIL+E + G +F + + + + +LG P M+ Q + RKYF
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
Query: 411 HHNQLDWDEHSSAGRYVRRRCKPL-KEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEA 469
E G + RR K L K++ ++ DLV RMLEY+P RI+ A
Sbjct: 348 --------ERLPGGGWTLRRTKELRKDYQGPGTRRLQE--DLVLRMLEYEPAARISPLGA 397
Query: 470 LQHPFF 475
LQH FF
Sbjct: 398 LQHGFF 403
>gi|4758222 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1B isoform a [Homo sapiens]
Length = 629
Score = 174 bits (441), Expect = 2e-43
Identities = 117/392 (29%), Positives = 189/392 (48%), Gaps = 57/392 (14%)
Query: 114 KRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKV 173
K++R + S +K ++ + +DD +++ +SG+ RYEI +G+G+FG+V
Sbjct: 67 KKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIV-RSGERWLERYEIDSLIGKGSFGQV 125
Query: 174 VECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHG 233
V+ DH + VA+KI+KN + A+ E+++LE +N D + V + F
Sbjct: 126 VKAYDHQTQEL-VAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRN 184
Query: 234 HVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPEN 291
H+C+VFELL + YD ++ F ++ R++A Q+C ++ FL +L+ H DLKPEN
Sbjct: 185 HLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPEN 244
Query: 292 ILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA 351
IL K + IK+VDFGS+ + + +R YR+PEV+L
Sbjct: 245 ILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLG 287
Query: 352 LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMI-QKTRKRKYF 410
+ D+WS+GCIL+E + G +F + + + + +LG P M+ Q + RKYF
Sbjct: 288 TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYF 347
Query: 411 HHNQLDWDEHSSAGRYVRRRCKPLKEFML---------------------------CHDE 443
E G + RR K L++
Sbjct: 348 --------ERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPA 399
Query: 444 EHEKLFDLVRRMLEYDPTQRITLDEALQHPFF 475
++ + DLV RMLEY+P RI+ ALQH FF
Sbjct: 400 DYLRFQDLVLRMLEYEPAARISPLGALQHGFF 431
>gi|18765756 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 5 [Homo sapiens]
Length = 529
Score = 172 bits (435), Expect = 8e-43
Identities = 115/386 (29%), Positives = 189/386 (48%), Gaps = 45/386 (11%)
Query: 115 RKRNRHCSSHQSRSKSHRRKRSRSIE--DDEEGHLICQSGDVLRARYEIVDTLGEGAFGK 172
+K+ RH Q SH+++R + DD+ I ++G+ RYEI +G+G+FG+
Sbjct: 114 KKKRRH-QQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQ 172
Query: 173 VVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHH 232
VV+ D ++ VA+KI+KN + A+ E+++LE +N D + V + F
Sbjct: 173 VVKAYDR-VEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 231
Query: 233 GHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPE 290
H+C+VFE+L + YD ++ +F ++ R+ A Q+C ++ FL +L+ H DLKPE
Sbjct: 232 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 291
Query: 291 NILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVIL 350
NIL K + IK+VDFGS+ + + +R YR+PEV+L
Sbjct: 292 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 334
Query: 351 ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYF 410
+ + D+WS+GCIL+E + G +F + + + + +LG P H++ + K + F
Sbjct: 335 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 394
Query: 411 HHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHD---------------------EEHEKLF 449
D + + +R KP L H+ ++ K
Sbjct: 395 FEKLPDGTWNLKKTKDGKREYKPPGTRKL-HNILGVETGGPGGRRAGESGHTVADYLKFK 453
Query: 450 DLVRRMLEYDPTQRITLDEALQHPFF 475
DL+ RML+YDP RI ALQH FF
Sbjct: 454 DLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|18765754 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 4 [Homo sapiens]
Length = 540
Score = 172 bits (435), Expect = 8e-43
Identities = 115/386 (29%), Positives = 189/386 (48%), Gaps = 45/386 (11%)
Query: 115 RKRNRHCSSHQSRSKSHRRKRSRSIE--DDEEGHLICQSGDVLRARYEIVDTLGEGAFGK 172
+K+ RH Q SH+++R + DD+ I ++G+ RYEI +G+G+FG+
Sbjct: 114 KKKRRH-QQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQ 172
Query: 173 VVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHH 232
VV+ D ++ VA+KI+KN + A+ E+++LE +N D + V + F
Sbjct: 173 VVKAYDR-VEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 231
Query: 233 GHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPE 290
H+C+VFE+L + YD ++ +F ++ R+ A Q+C ++ FL +L+ H DLKPE
Sbjct: 232 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 291
Query: 291 NILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVIL 350
NIL K + IK+VDFGS+ + + +R YR+PEV+L
Sbjct: 292 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 334
Query: 351 ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYF 410
+ + D+WS+GCIL+E + G +F + + + + +LG P H++ + K + F
Sbjct: 335 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 394
Query: 411 HHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHD---------------------EEHEKLF 449
D + + +R KP L H+ ++ K
Sbjct: 395 FEKLPDGTWNLKKTKDGKREYKPPGTRKL-HNILGVETGGPGGRRAGESGHTVADYLKFK 453
Query: 450 DLVRRMLEYDPTQRITLDEALQHPFF 475
DL+ RML+YDP RI ALQH FF
Sbjct: 454 DLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|18765750 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 3 [Homo sapiens]
Length = 584
Score = 172 bits (435), Expect = 8e-43
Identities = 115/386 (29%), Positives = 189/386 (48%), Gaps = 45/386 (11%)
Query: 115 RKRNRHCSSHQSRSKSHRRKRSRSIE--DDEEGHLICQSGDVLRARYEIVDTLGEGAFGK 172
+K+ RH Q SH+++R + DD+ I ++G+ RYEI +G+G+FG+
Sbjct: 114 KKKRRH-QQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQ 172
Query: 173 VVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHH 232
VV+ D ++ VA+KI+KN + A+ E+++LE +N D + V + F
Sbjct: 173 VVKAYDR-VEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 231
Query: 233 GHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPE 290
H+C+VFE+L + YD ++ +F ++ R+ A Q+C ++ FL +L+ H DLKPE
Sbjct: 232 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 291
Query: 291 NILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVIL 350
NIL K + IK+VDFGS+ + + +R YR+PEV+L
Sbjct: 292 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 334
Query: 351 ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYF 410
+ + D+WS+GCIL+E + G +F + + + + +LG P H++ + K + F
Sbjct: 335 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 394
Query: 411 HHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHD---------------------EEHEKLF 449
D + + +R KP L H+ ++ K
Sbjct: 395 FEKLPDGTWNLKKTKDGKREYKPPGTRKL-HNILGVETGGPGGRRAGESGHTVADYLKFK 453
Query: 450 DLVRRMLEYDPTQRITLDEALQHPFF 475
DL+ RML+YDP RI ALQH FF
Sbjct: 454 DLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|18765752 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 2 [Homo sapiens]
Length = 754
Score = 172 bits (435), Expect = 8e-43
Identities = 115/386 (29%), Positives = 189/386 (48%), Gaps = 45/386 (11%)
Query: 115 RKRNRHCSSHQSRSKSHRRKRSRSIE--DDEEGHLICQSGDVLRARYEIVDTLGEGAFGK 172
+K+ RH Q SH+++R + DD+ I ++G+ RYEI +G+G+FG+
Sbjct: 105 KKKRRH-QQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQ 163
Query: 173 VVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHH 232
VV+ D ++ VA+KI+KN + A+ E+++LE +N D + V + F
Sbjct: 164 VVKAYDR-VEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 222
Query: 233 GHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPE 290
H+C+VFE+L + YD ++ +F ++ R+ A Q+C ++ FL +L+ H DLKPE
Sbjct: 223 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 282
Query: 291 NILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVIL 350
NIL K + IK+VDFGS+ + + +R YR+PEV+L
Sbjct: 283 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 325
Query: 351 ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYF 410
+ + D+WS+GCIL+E + G +F + + + + +LG P H++ + K + F
Sbjct: 326 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 385
Query: 411 HHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHD---------------------EEHEKLF 449
D + + +R KP L H+ ++ K
Sbjct: 386 FEKLPDGTWNLKKTKDGKREYKPPGTRKL-HNILGVETGGPGGRRAGESGHTVADYLKFK 444
Query: 450 DLVRRMLEYDPTQRITLDEALQHPFF 475
DL+ RML+YDP RI ALQH FF
Sbjct: 445 DLILRMLDYDPKTRIQPYYALQHSFF 470
>gi|18765758 dual-specificity tyrosine-(Y)-phosphorylation regulated
kinase 1A isoform 1 [Homo sapiens]
Length = 763
Score = 172 bits (435), Expect = 8e-43
Identities = 115/386 (29%), Positives = 189/386 (48%), Gaps = 45/386 (11%)
Query: 115 RKRNRHCSSHQSRSKSHRRKRSRSIE--DDEEGHLICQSGDVLRARYEIVDTLGEGAFGK 172
+K+ RH Q SH+++R + DD+ I ++G+ RYEI +G+G+FG+
Sbjct: 114 KKKRRH-QQGQGDDSSHKKERKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQ 172
Query: 173 VVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHH 232
VV+ D ++ VA+KI+KN + A+ E+++LE +N D + V + F
Sbjct: 173 VVKAYDR-VEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFR 231
Query: 233 GHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLT--HTDLKPE 290
H+C+VFE+L + YD ++ +F ++ R+ A Q+C ++ FL +L+ H DLKPE
Sbjct: 232 NHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPE 291
Query: 291 NILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVIL 350
NIL K + IK+VDFGS+ + + +R YR+PEV+L
Sbjct: 292 NILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLL 334
Query: 351 ALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYF 410
+ + D+WS+GCIL+E + G +F + + + + +LG P H++ + K + F
Sbjct: 335 GMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKF 394
Query: 411 HHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHD---------------------EEHEKLF 449
D + + +R KP L H+ ++ K
Sbjct: 395 FEKLPDGTWNLKKTKDGKREYKPPGTRKL-HNILGVETGGPGGRRAGESGHTVADYLKFK 453
Query: 450 DLVRRMLEYDPTQRITLDEALQHPFF 475
DL+ RML+YDP RI ALQH FF
Sbjct: 454 DLILRMLDYDPKTRIQPYYALQHSFF 479
>gi|164420691 homeodomain interacting protein kinase 2 isoform 2
[Homo sapiens]
Length = 1171
Score = 166 bits (420), Expect = 4e-41
Identities = 104/345 (30%), Positives = 174/345 (50%), Gaps = 46/345 (13%)
Query: 159 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 218
YE+++ LG G FG+VV+C G + + VA+KI+KN Y + E+ +L L ST+
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEI-VAIKILKNHPSYARQGQIEVSILARL-STESAD 256
Query: 219 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLH 278
+ V+ E F H H C+VFE+L + YDF+K+N F P + +IR + Q+ ++ L
Sbjct: 257 DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
Query: 279 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH-HSTL 337
L H DLKPENI+ V + + + +KV+DFGSA++ + ST
Sbjct: 317 SLGLIHADLKPENIMLV---------------DPSRQPYRVKVIDFGSASHVSKAVCSTY 361
Query: 338 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIP 397
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++ + + + + G
Sbjct: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421
Query: 398 QHMIQKTRKRKYFHHNQLD-----W-----DEHSS--------AGRYVRRRCKPLKEF-- 437
++++ K F + D W D+H + A +Y+ + +
Sbjct: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481
Query: 438 --------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPF 474
ML + + DL+++ML D +RIT E L HPF
Sbjct: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526
>gi|164420685 homeodomain interacting protein kinase 2 isoform 1
[Homo sapiens]
Length = 1198
Score = 166 bits (420), Expect = 4e-41
Identities = 104/345 (30%), Positives = 174/345 (50%), Gaps = 46/345 (13%)
Query: 159 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 218
YE+++ LG G FG+VV+C G + + VA+KI+KN Y + E+ +L L ST+
Sbjct: 199 YEVLEFLGRGTFGQVVKCWKRGTNEI-VAIKILKNHPSYARQGQIEVSILARL-STESAD 256
Query: 219 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLH 278
+ V+ E F H H C+VFE+L + YDF+K+N F P + +IR + Q+ ++ L
Sbjct: 257 DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVATALMKLK 316
Query: 279 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH-HSTL 337
L H DLKPENI+ V + + + +KV+DFGSA++ + ST
Sbjct: 317 SLGLIHADLKPENIMLV---------------DPSRQPYRVKVIDFGSASHVSKAVCSTY 361
Query: 338 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIP 397
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++ + + + + G
Sbjct: 362 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 421
Query: 398 QHMIQKTRKRKYFHHNQLD-----W-----DEHSS--------AGRYVRRRCKPLKEF-- 437
++++ K F + D W D+H + A +Y+ + +
Sbjct: 422 EYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVNM 481
Query: 438 --------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPF 474
ML + + DL+++ML D +RIT E L HPF
Sbjct: 482 TTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 526
>gi|114796630 homeodomain interacting protein kinase 3 isoform 2
[Homo sapiens]
Length = 1194
Score = 158 bits (400), Expect = 9e-39
Identities = 104/352 (29%), Positives = 174/352 (49%), Gaps = 46/352 (13%)
Query: 155 LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNST 214
++ YE++D LG G FG+VV+C G + + VA+KI+KN Y + E+ +L L ST
Sbjct: 193 MKNTYEVLDFLGRGTFGQVVKCWKRGTNEI-VAIKILKNHPSYARQGQIEVSILARL-ST 250
Query: 215 DPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSI 274
+ + V+ E F H H C+VFE+L + YDF+K+N F P + IR + Q+ ++
Sbjct: 251 ENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATAL 310
Query: 275 NFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH- 333
L L H DLKPENI+ V +++ R +KV+DFGSA++ +
Sbjct: 311 KKLKSLGLIHADLKPENIMLV---------DPVRQPYR------VKVIDFGSASHVSKTV 355
Query: 334 HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERIL 393
ST + +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++ + + + +
Sbjct: 356 CSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQ 415
Query: 394 GPIPQHMIQKTRKRKYFHHNQLD-----W-----DEHSS--------AGRYVRRRCKPLK 435
G + ++ K F + D W +EH + A +Y+ +
Sbjct: 416 GLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVA 475
Query: 436 EF----------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDL 477
+L + + L+++ML D RIT E L HPF ++
Sbjct: 476 HVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527
>gi|114796624 homeodomain interacting protein kinase 3 isoform 1
[Homo sapiens]
Length = 1215
Score = 158 bits (400), Expect = 9e-39
Identities = 104/352 (29%), Positives = 174/352 (49%), Gaps = 46/352 (13%)
Query: 155 LRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNST 214
++ YE++D LG G FG+VV+C G + + VA+KI+KN Y + E+ +L L ST
Sbjct: 193 MKNTYEVLDFLGRGTFGQVVKCWKRGTNEI-VAIKILKNHPSYARQGQIEVSILARL-ST 250
Query: 215 DPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSI 274
+ + V+ E F H H C+VFE+L + YDF+K+N F P + IR + Q+ ++
Sbjct: 251 ENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATAL 310
Query: 275 NFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH- 333
L L H DLKPENI+ V +++ R +KV+DFGSA++ +
Sbjct: 311 KKLKSLGLIHADLKPENIMLV---------DPVRQPYR------VKVIDFGSASHVSKTV 355
Query: 334 HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERIL 393
ST + +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++ + + + +
Sbjct: 356 CSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQ 415
Query: 394 GPIPQHMIQKTRKRKYFHHNQLD-----W-----DEHSS--------AGRYVRRRCKPLK 435
G + ++ K F + D W +EH + A +Y+ +
Sbjct: 416 GLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVA 475
Query: 436 EF----------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDL 477
+L + + L+++ML D RIT E L HPF ++
Sbjct: 476 HVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNM 527
>gi|89276756 serine/threonine-protein kinase PRP4K [Homo sapiens]
Length = 1007
Score = 154 bits (390), Expect = 1e-37
Identities = 105/352 (29%), Positives = 175/352 (49%), Gaps = 38/352 (10%)
Query: 142 DEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAA 201
D EG+ G+VL RY + G+G F VV D+ VAVKI++N ++
Sbjct: 670 DAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTG 729
Query: 202 RSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKE-NSFLPFQI 260
E++ L+ LN DP+ F C+++ F H H+C+VFE L ++ + +K+ + I
Sbjct: 730 LKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHI 789
Query: 261 DHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIK 320
+R + Q+ ++ L + H D+KP+NIL +S T +K
Sbjct: 790 KAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNES------------------KTILK 831
Query: 321 VVDFGSATY--DDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQ 378
+ DFGSA++ D++ LVS R YRAPE+I+ + D+WS+GC L E Y G +F
Sbjct: 832 LCDFGSASHVADNDITPYLVS-RFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFP 890
Query: 379 THDSKEHLAMMERILGPIPQHMIQK-TRKRKYFHHN----QLDWDEHSSAGRY-VRRRCK 432
+ L + + G +P MI+K K ++F N ++ D+ + + V
Sbjct: 891 GKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTIN 950
Query: 433 PLKEFM--------LCHDEEHE--KLFDLVRRMLEYDPTQRITLDEALQHPF 474
P K+ + L D+ + +L DL+ ++L DP +RI++++ALQH F
Sbjct: 951 PTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAF 1002
Score = 32.3 bits (72), Expect = 0.98
Identities = 41/160 (25%), Positives = 63/160 (39%), Gaps = 25/160 (15%)
Query: 2 RHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARS 61
+H K H + D + H+ HKRK +S +E P + K D LE
Sbjct: 53 KHKKHKHSSEEDKDKKHKHKHKHKKHKRKEIIDASDKEG--MSPAKRTKLDDLALLE--- 107
Query: 62 LNERDYRDRRYV--DEYRNDYCEGYVP-------RHYHRDIESGYRIH-----CSKSSVR 107
D +R + E N+ EG V + Y E IH ++SS R
Sbjct: 108 ----DLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTR 163
Query: 108 SRRSSPKRK--RNRHCSSHQSRSKSHRRKRSRSIEDDEEG 145
S + K + N+ + +S+S+S R R RS + +G
Sbjct: 164 SSSTKGKLELVDNKITTKKRSKSRSKERTRHRSDKKKSKG 203
Score = 29.3 bits (64), Expect = 8.3
Identities = 19/46 (41%), Positives = 28/46 (60%), Gaps = 4/46 (8%)
Query: 102 SKSSVRSRRSSPKRKRNRHCSSH---QSRSKSHRRKRSRS-IEDDE 143
S+S R RS +R R R S +SRS+ RR+RSRS +++D+
Sbjct: 458 SRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDK 503
>gi|38201640 homeodomain-interacting protein kinase 1 isoform 1
[Homo sapiens]
Length = 1210
Score = 153 bits (387), Expect = 3e-37
Identities = 99/345 (28%), Positives = 171/345 (49%), Gaps = 46/345 (13%)
Query: 159 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 218
YE+++ LG G FG+V +C + VA+KI+KN Y + E+ +L L+S + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEI-VAIKILKNHPSYARQGQIEVSILSRLSSENADE 248
Query: 219 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLH 278
+ V+ E F H H C+VFE+L + YDF+K+N F P + +IR + Q+ ++ L
Sbjct: 249 -YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLK 307
Query: 279 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH-HSTL 337
L H DLKPENI+ V +++ R +KV+DFGSA++ + ST
Sbjct: 308 SLGLIHADLKPENIMLV---------DPVRQPYR------VKVIDFGSASHVSKAVCSTY 352
Query: 338 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIP 397
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++ + + + + G
Sbjct: 353 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 412
Query: 398 QHMIQKTRKRKYFHHNQLD-----W-----DEH--------SSAGRYVRRRCKPLKEF-- 437
++++ K F + + W +EH A +Y+ + +
Sbjct: 413 EYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 472
Query: 438 --------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPF 474
ML + + DL+++ML D +RIT + L H F
Sbjct: 473 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQF 517
>gi|38201638 homeodomain-interacting protein kinase 1 isoform 2
[Homo sapiens]
Length = 1075
Score = 153 bits (387), Expect = 3e-37
Identities = 99/345 (28%), Positives = 171/345 (49%), Gaps = 46/345 (13%)
Query: 159 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 218
YE+++ LG G FG+V +C + VA+KI+KN Y + E+ +L L+S + +
Sbjct: 190 YEVLEFLGRGTFGQVAKCWKRSTKEI-VAIKILKNHPSYARQGQIEVSILSRLSSENADE 248
Query: 219 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLH 278
+ V+ E F H H C+VFE+L + YDF+K+N F P + +IR + Q+ ++ L
Sbjct: 249 -YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLK 307
Query: 279 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEH-HSTL 337
L H DLKPENI+ V +++ R +KV+DFGSA++ + ST
Sbjct: 308 SLGLIHADLKPENIMLV---------DPVRQPYR------VKVIDFGSASHVSKAVCSTY 352
Query: 338 VSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIP 397
+ +R+YRAPE+IL L + + D+WS+GC++ E +LG+ ++ + + + + G
Sbjct: 353 LQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPA 412
Query: 398 QHMIQKTRKRKYFHHNQLD-----W-----DEH--------SSAGRYVRRRCKPLKEF-- 437
++++ K F + + W +EH A +Y+ + +
Sbjct: 413 EYLLSAGTKTTRFFNRDPNLGYPLWRLKTPEEHELETGIKSKEARKYIFNCLDDMAQVNM 472
Query: 438 --------MLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPF 474
ML + + DL+++ML D +RIT + L H F
Sbjct: 473 STDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHQF 517
>gi|31542768 homeodomain interacting protein kinase 4 [Homo sapiens]
Length = 616
Score = 141 bits (355), Expect = 1e-33
Identities = 97/356 (27%), Positives = 170/356 (47%), Gaps = 54/356 (15%)
Query: 159 YEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNS 218
Y+I++ LG+G FG+V + M VA+KI+KN ++E+++L + DP
Sbjct: 11 YDIIEVLGKGTFGEVAKGWRRSTGEM-VAIKILKNDAYRNRIIKNELKLLHCMRGLDPEE 69
Query: 219 VFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLH 278
++ LE+F +VFELL + ++F KEN+F P HIR + Q+ ++ L
Sbjct: 70 A-HVIRFLEFFHDALKFYLVFELLEQNLFEFQKENNFAPLPARHIRTVTLQVLTALARLK 128
Query: 279 HNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHH---S 335
+ H DLKPENI+ V ++T +KV+DFGSA+ E
Sbjct: 129 ELAIIHADLKPENIMLV---------------DQTRCPFRVKVIDFGSASIFSEVRYVKE 173
Query: 336 TLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGP 395
+ +R YRAPE++L L + + DVWS+GC++ E +LG+ ++ ++ + + + G
Sbjct: 174 PYIQSRFYRAPEILLGLPFCEKVDVWSLGCVMAELHLGWPLYPGNNEYDQVRYICETQGL 233
Query: 396 IPQHMIQKTRKRKYF-----HHNQLD-WDEHSSAGRYVRRRCKPL--KEFM--------- 438
H++ K +F H + + W SSA + +PL +++M
Sbjct: 234 PKPHLLHAACKAHHFFKRNPHPDAANPWQLKSSADYLAETKVRPLERRKYMLKSLDQIET 293
Query: 439 -----------------LCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDL 477
L + + + +L++RML ++ +RI+ AL+HPF +
Sbjct: 294 VNGGSVASRLTFPDREALAEHADLKSMVELIKRMLTWESHERISPSAALRHPFVSM 349
>gi|83367069 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 121 bits (304), Expect = 1e-27
Identities = 87/330 (26%), Positives = 159/330 (48%), Gaps = 45/330 (13%)
Query: 152 GDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHL 211
G+V+ ++EI+ +GEGA+G V++C H VA+K K+ E + ++ L+ L
Sbjct: 7 GNVMN-KFEILGVVGEGAYGVVLKC-RHKETHEIVAIKKFKDSEENEEVKETTLRELKML 64
Query: 212 NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKE--NSFLPFQIDHIRQMAYQ 269
+ ++ V++ E F G + +VFE + + + ++E N P + ++ YQ
Sbjct: 65 RTLKQENI---VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPP---EKVKSYIYQ 118
Query: 270 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY 329
+ ++I++ H N + H D+KPEN+L +D +K+ DFG A
Sbjct: 119 LIKAIHWCHKNDIVHRDIKPENLLISHNDV-------------------LKLCDFGFARN 159
Query: 330 DDE----HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEH 385
E +++ V+TR YR+PE++L + + D+WS+GCIL E G +F +
Sbjct: 160 LSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQ 219
Query: 386 LAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEH 445
L ++++LGP+P ++ FH + H + + RR + +
Sbjct: 220 LFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQS---LERRYLGIL---------N 267
Query: 446 EKLFDLVRRMLEYDPTQRITLDEALQHPFF 475
L DL++ +L+ DP R ++ L HP F
Sbjct: 268 SVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
>gi|4507281 cyclin-dependent kinase-like 5 [Homo sapiens]
Length = 1030
Score = 121 bits (304), Expect = 1e-27
Identities = 87/330 (26%), Positives = 159/330 (48%), Gaps = 45/330 (13%)
Query: 152 GDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHL 211
G+V+ ++EI+ +GEGA+G V++C H VA+K K+ E + ++ L+ L
Sbjct: 7 GNVMN-KFEILGVVGEGAYGVVLKC-RHKETHEIVAIKKFKDSEENEEVKETTLRELKML 64
Query: 212 NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKE--NSFLPFQIDHIRQMAYQ 269
+ ++ V++ E F G + +VFE + + + ++E N P + ++ YQ
Sbjct: 65 RTLKQENI---VELKEAFRRRGKLYLVFEYVEKNMLELLEEMPNGVPP---EKVKSYIYQ 118
Query: 270 ICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATY 329
+ ++I++ H N + H D+KPEN+L +D +K+ DFG A
Sbjct: 119 LIKAIHWCHKNDIVHRDIKPENLLISHNDV-------------------LKLCDFGFARN 159
Query: 330 DDE----HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEH 385
E +++ V+TR YR+PE++L + + D+WS+GCIL E G +F +
Sbjct: 160 LSEGNNANYTEYVATRWYRSPELLLGAPYGKSVDMWSVGCILGELSDGQPLFPGESEIDQ 219
Query: 386 LAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEH 445
L ++++LGP+P ++ FH + H + + RR + +
Sbjct: 220 LFTIQKVLGPLPSEQMKLFYSNPRFHGLRFPAVNHPQS---LERRYLGIL---------N 267
Query: 446 EKLFDLVRRMLEYDPTQRITLDEALQHPFF 475
L DL++ +L+ DP R ++ L HP F
Sbjct: 268 SVLLDLMKNLLKLDPADRYLTEQCLNHPTF 297
>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
sapiens]
Length = 360
Score = 114 bits (284), Expect = 3e-25
Identities = 90/326 (27%), Positives = 150/326 (46%), Gaps = 48/326 (14%)
Query: 158 RYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGR---YREAARSEIQVLEHL--- 211
RY+ + +G GA+G V D G+ VAVK + + + + E+++L+H+
Sbjct: 23 RYQNLSPVGSGAYGSVCAAFDT-KTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHE 81
Query: 212 NSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQIC 271
N VF + LE F+ V +V L+G + +K DH++ + YQI
Sbjct: 82 NVIGLLDVFTPARSLEEFND---VYLVTHLMGADLNNIVKCQKLTD---DHVQFLIYQIL 135
Query: 272 QSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDD 331
+ + ++H + H DLKP N L V D ++K++DFG A + D
Sbjct: 136 RGLKYIHSADIIHRDLKPSN-LAVNED------------------CELKILDFGLARHTD 176
Query: 332 EHHSTLVSTRHYRAPEVILA-LGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMME 390
+ + V+TR YRAPE++L + ++Q D+WS+GCI+ E G T+F D L +
Sbjct: 177 DEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHINQLQQIM 236
Query: 391 RILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCK-PLKEFMLCHDEEHEKLF 449
R+ G P ++I + + A Y++ + P F +
Sbjct: 237 RLTGTPPAYLINRMPSHE--------------ARNYIQSLTQMPKMNFANVFIGANPLAV 282
Query: 450 DLVRRMLEYDPTQRITLDEALQHPFF 475
DL+ +ML D +RIT +AL H +F
Sbjct: 283 DLLEKMLVLDSDKRITAAQALAHAYF 308
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.136 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,192,592
Number of Sequences: 37866
Number of extensions: 867390
Number of successful extensions: 6328
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 522
Number of HSP's successfully gapped in prelim test: 305
Number of HSP's that attempted gapping in prelim test: 3290
Number of HSP's gapped (non-prelim): 1876
length of query: 481
length of database: 18,247,518
effective HSP length: 106
effective length of query: 375
effective length of database: 14,233,722
effective search space: 5337645750
effective search space used: 5337645750
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.