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Search of human proteins with 169636428
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169636428 calicin [Homo sapiens]
(588 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169636428 calicin [Homo sapiens] 1199 0.0
gi|8922528 kelch-like 11 [Homo sapiens] 137 2e-32
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 122 1e-27
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 120 3e-27
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 120 3e-27
gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 115 9e-26
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 115 1e-25
gi|194097389 kelch-like 38 [Homo sapiens] 115 1e-25
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 113 6e-25
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 113 6e-25
gi|55925608 kelch-like 21 [Homo sapiens] 111 2e-24
gi|40807500 kelch-like 20 [Homo sapiens] 110 3e-24
gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens] 110 5e-24
gi|128485503 kelch-like 30 [Homo sapiens] 109 6e-24
gi|38327518 BTB and kelch domain containing 3 [Homo sapiens] 107 4e-23
gi|38327516 BTB and kelch domain containing 3 [Homo sapiens] 107 4e-23
gi|148664209 kelch-like 10 [Homo sapiens] 105 1e-22
gi|11545731 gigaxonin [Homo sapiens] 105 2e-22
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 103 3e-22
gi|40255071 kelch-like 23 [Homo sapiens] 103 4e-22
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 103 6e-22
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 102 1e-21
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 102 1e-21
gi|55925604 kelch-like 18 [Homo sapiens] 100 5e-21
gi|156616301 kelch-like 32 [Homo sapiens] 100 6e-21
gi|227497736 T-cell activation kelch repeat protein [Homo sapiens] 99 8e-21
gi|14780904 kelch-like 1 protein [Homo sapiens] 97 4e-20
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 95 2e-19
gi|11056006 kelch-like 12 [Homo sapiens] 95 2e-19
gi|38194229 kelch-like 17 [Homo sapiens] 95 2e-19
>gi|169636428 calicin [Homo sapiens]
Length = 588
Score = 1199 bits (3101), Expect = 0.0
Identities = 588/588 (100%), Positives = 588/588 (100%)
Query: 1 MKLEFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSN 60
MKLEFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSN
Sbjct: 1 MKLEFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSN 60
Query: 61 DMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHC 120
DMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHC
Sbjct: 61 DMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHC 120
Query: 121 NDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIF 180
NDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIF
Sbjct: 121 NDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIF 180
Query: 181 GRLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKL 240
GRLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKL
Sbjct: 181 GRLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKL 240
Query: 241 VGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAY 300
VGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAY
Sbjct: 241 VGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAY 300
Query: 301 IIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPD 360
IIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPD
Sbjct: 301 IIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPD 360
Query: 361 LPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVIT 420
LPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVIT
Sbjct: 361 LPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVIT 420
Query: 421 KGDRHLYIVTGRCLVKGYISRVGVVDCFDTSTGDVVQCITFPIEFNHRPLLSFQQDNILC 480
KGDRHLYIVTGRCLVKGYISRVGVVDCFDTSTGDVVQCITFPIEFNHRPLLSFQQDNILC
Sbjct: 421 KGDRHLYIVTGRCLVKGYISRVGVVDCFDTSTGDVVQCITFPIEFNHRPLLSFQQDNILC 480
Query: 481 VHSHRQSVEINLQKVKASKTTTSVPVLPNSCPLDVSHAICSIGDSKVFVCGGVTTASDVQ 540
VHSHRQSVEINLQKVKASKTTTSVPVLPNSCPLDVSHAICSIGDSKVFVCGGVTTASDVQ
Sbjct: 481 VHSHRQSVEINLQKVKASKTTTSVPVLPNSCPLDVSHAICSIGDSKVFVCGGVTTASDVQ 540
Query: 541 TKDYTINPNAFLLDQKTGKWKTLAPPPEALDCPACCLAKLPCKILQRI 588
TKDYTINPNAFLLDQKTGKWKTLAPPPEALDCPACCLAKLPCKILQRI
Sbjct: 541 TKDYTINPNAFLLDQKTGKWKTLAPPPEALDCPACCLAKLPCKILQRI 588
>gi|8922528 kelch-like 11 [Homo sapiens]
Length = 708
Score = 137 bits (346), Expect = 2e-32
Identities = 139/593 (23%), Positives = 245/593 (41%), Gaps = 37/593 (6%)
Query: 19 NRQRKRKEYWDMAL---SVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTAD---ELFITI 72
N QR++ + D+ L F AHR+VLAA + L+S ++ E+
Sbjct: 85 NEQRRQGLFCDITLCFGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKWS 144
Query: 73 DTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRAN 132
P TV+ +++Y Y+G++ +S +V E+L A F RL+ C +FL K + +N
Sbjct: 145 SEPGPEPDTVEAVIEYMYTGRIRVSTGSVHEVLELADRFLLIRLKEFCGEFLKKKLHLSN 204
Query: 133 CLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVL 192
C+ LA ++ L +++ A IR NFH E F P + L D + V
Sbjct: 205 CVAIHSLAHMYTLSQLALKAADMIRRNFHKVIQDE---EFYTLPFHLIRDWLSDLEITVD 261
Query: 193 NEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTL--------VFASN----KL 240
+E+ ++ WV E+RE+YF++ F + L+ + L + A+N KL
Sbjct: 262 SEEVLFETVLKWVQRNAEERERYFEELFKLLRLSQMKPTYLTRHVKPERLVANNEVCVKL 321
Query: 241 VGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAY 300
V + H E++ Q + + R G +D ++++GG G + Y
Sbjct: 322 VA-DAVERHALRAENIQSGTCQHPTSHVSLLPRYGQNMDVIMVIGGVSEGGDYLSECVGY 380
Query: 301 IIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPD 360
+ E+ W+ L + + Y+Y++G + KT RY+ + N+W +
Sbjct: 381 FVDEDRWVNLPHIHNHLDGHAVAVTESYVYVAGSMEPGFA--KTVERYNPNLNTWEHVCS 438
Query: 361 LPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVW-CLAGKMSIPMDGTAVI 419
L + G +YS+GG ++ Y+ + W L I D A+
Sbjct: 439 LMTRKHSFGLTEVKGKLYSIGGHGNFSPGFKDVTVYNPELDKWHNLESAPKILRDVKALA 498
Query: 420 TKGDRHLYIVTGRCLVKGYISRV-GVVDCFDTSTGDVVQCITFPIEFNHRPL------LS 472
+ DR +YI + + + V+ C+DT T + P+ N+ +
Sbjct: 499 IE-DRFVYIAARTPVDRDTEDGLKAVITCYDTETRQWQDVESLPLIDNYCFFQMSVVNSN 557
Query: 473 FQQDNILCVHSHRQSVEINLQKVKASKTTTSVPVLPNSCPLDVSHAICSIGDSKVFVCGG 532
F Q C S+ E ++K+ + + + LP AIC D VF+ GG
Sbjct: 558 FYQTASCCPKSYCLENEEAVRKIASQVSDEILESLPPEVLSIEGAAICYYKDD-VFIIGG 616
Query: 533 VTTASDVQTKDYTINPNAFLLDQKTGKWKTLAPPPEALDCPACCLAKLPCKIL 585
+ D+ K Y + ++K +W L P P+ C ++P + L
Sbjct: 617 WKNSDDID-KQYRKEAYRYCAERK--RWMLLPPMPQPRCRATACHVRIPYRYL 666
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 122 bits (305), Expect = 1e-27
Identities = 103/436 (23%), Positives = 182/436 (41%), Gaps = 37/436 (8%)
Query: 5 FTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKT 64
F + +Y VL +LN R+++ + D+ L N F HR VLAA S ++ S +K
Sbjct: 23 FHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGG-LKE 81
Query: 65 ADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFL 124
+ + + D S + P ++ LLDY YS +V+I+E+N E LL +R C +FL
Sbjct: 82 SQDSEVNFDNS-IHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFL 140
Query: 125 IKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLL 184
K++ NCL L L++ + ++ ++++ NF E F++ P + +LL
Sbjct: 141 EKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNE---DFLQLPQDMVVQLL 197
Query: 185 RDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLV--FASNKLVG 242
E L +E + INW+ + + R Y + + L + L+ A +L+
Sbjct: 198 SSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELIT 257
Query: 243 MENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLD----------SVVILGGQKAHGQ 292
+ S ++E + C L + Q G + ++ +LGGQ
Sbjct: 258 KQRKSKE--IVEEAIR-------CKLKILQNDGVVTSLCARPRKTGHALFLLGGQTF--- 305
Query: 293 FNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDD 352
D ++ + + +D+P SA + G +YI+GG + K W YD
Sbjct: 306 MCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLH 365
Query: 353 NSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIA--------PRRYVSNIYRYDERKEVWC 404
W+K + + H +Y VGG A P + + YD W
Sbjct: 366 EEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWT 425
Query: 405 LAGKMSIPMDGTAVIT 420
+ + + AV++
Sbjct: 426 MVAPLREGVSNAAVVS 441
Score = 40.8 bits (94), Expect = 0.004
Identities = 28/100 (28%), Positives = 44/100 (44%), Gaps = 3/100 (3%)
Query: 304 ENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPI 363
EN W + P +A G I+I GG TE +A++++ + WTK+ D+
Sbjct: 469 ENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTE--FSACSAYKFNSETYQWTKVGDVTA 526
Query: 364 GLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVW 403
+ V G +Y VGG +R + YD +VW
Sbjct: 527 KRMSCHAVASGNKLYVVGGYFGIQR-CKTLDCYDPTLDVW 565
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 120 bits (301), Expect = 3e-27
Identities = 104/445 (23%), Positives = 188/445 (42%), Gaps = 25/445 (5%)
Query: 2 KLEFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLI--SS 59
K EFT+ + +L+ LN+QR+ K + D+ + V+ F H+NVLA+ S + LI S
Sbjct: 303 KYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSV 362
Query: 60 NDMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVH 119
D + + S L ++ LL++ Y+G +VI N + LL A F
Sbjct: 363 QDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
Query: 120 CNDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVI 179
C FL K + +NCL L +AE + E+ +A + F A+ E + + +
Sbjct: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
Query: 180 FGRLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYIN---------LNAVSN 230
+ + +++L+ E+ +I W+ R +Y + + LN V N
Sbjct: 483 Y---VSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDN 539
Query: 231 KTLVFASNKLVGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAH 290
+ L+ +S + N + ++ + + R L + + +V++GG++
Sbjct: 540 EELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRL----SAGVAEVIVLVGGRQMV 595
Query: 291 GQFNDGVFAYII---QENLWMKLSDMP-YRAAALSATSAGRYIYISGGTTEQISGLKTAW 346
G + A Q N W L+ +P Y S SAG IY+SGG ++ L W
Sbjct: 596 GMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVT-LADVW 654
Query: 347 RYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLA 406
Y ++W + + + H + G +Y++GG + V ++ RYD W
Sbjct: 655 CYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG-LGVAGNVDHVERYDTITNQWEAV 713
Query: 407 GKMSIPMDGTAVITKGDRHLYIVTG 431
+ + A G + +Y+ G
Sbjct: 714 APLPKAVHSAAATVCGGK-IYVFGG 737
Score = 41.2 bits (95), Expect = 0.003
Identities = 33/117 (28%), Positives = 47/117 (40%), Gaps = 7/117 (5%)
Query: 269 LVYQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRY 328
LVY K + LGG G D V Y N W ++ +P + +AT G
Sbjct: 679 LVYDGK------IYTLGGLGVAGNV-DHVERYDTITNQWEAVAPLPKAVHSAAATVCGGK 731
Query: 329 IYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIA 385
IY+ GG E Y N+W+ + I + VT G V+ +GG+ A
Sbjct: 732 IYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYA 788
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 120 bits (301), Expect = 3e-27
Identities = 104/445 (23%), Positives = 188/445 (42%), Gaps = 25/445 (5%)
Query: 2 KLEFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLI--SS 59
K EFT+ + +L+ LN+QR+ K + D+ + V+ F H+NVLA+ S + LI S
Sbjct: 303 KYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSV 362
Query: 60 NDMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVH 119
D + + S L ++ LL++ Y+G +VI N + LL A F
Sbjct: 363 QDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
Query: 120 CNDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVI 179
C FL K + +NCL L +AE + E+ +A + F A+ E + + +
Sbjct: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
Query: 180 FGRLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYIN---------LNAVSN 230
+ + +++L+ E+ +I W+ R +Y + + LN V N
Sbjct: 483 Y---VSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDN 539
Query: 231 KTLVFASNKLVGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAH 290
+ L+ +S + N + ++ + + R L + + +V++GG++
Sbjct: 540 EELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRL----SAGVAEVIVLVGGRQMV 595
Query: 291 GQFNDGVFAYII---QENLWMKLSDMP-YRAAALSATSAGRYIYISGGTTEQISGLKTAW 346
G + A Q N W L+ +P Y S SAG IY+SGG ++ L W
Sbjct: 596 GMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVT-LADVW 654
Query: 347 RYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLA 406
Y ++W + + + H + G +Y++GG + V ++ RYD W
Sbjct: 655 CYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG-LGVAGNVDHVERYDTITNQWEAV 713
Query: 407 GKMSIPMDGTAVITKGDRHLYIVTG 431
+ + A G + +Y+ G
Sbjct: 714 APLPKAVHSAAATVCGGK-IYVFGG 737
Score = 41.2 bits (95), Expect = 0.003
Identities = 33/117 (28%), Positives = 47/117 (40%), Gaps = 7/117 (5%)
Query: 269 LVYQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRY 328
LVY K + LGG G D V Y N W ++ +P + +AT G
Sbjct: 679 LVYDGK------IYTLGGLGVAGNV-DHVERYDTITNQWEAVAPLPKAVHSAAATVCGGK 731
Query: 329 IYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIA 385
IY+ GG E Y N+W+ + I + VT G V+ +GG+ A
Sbjct: 732 IYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAYA 788
>gi|239747686 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 702
Score = 115 bits (289), Expect = 9e-26
Identities = 95/396 (23%), Positives = 171/396 (43%), Gaps = 23/396 (5%)
Query: 2 KLEFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLI--SS 59
K EFT+ + +L+ LN+QR+ K + D+ + V+ F H+NVLA+ S + LI S
Sbjct: 303 KYEFTDPGHPREMLKELNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSV 362
Query: 60 NDMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVH 119
D + + S L ++ LL++ Y+G +VI N + LL A F
Sbjct: 363 QDSGQGGREKLELVLSNLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKV 422
Query: 120 CNDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVI 179
C FL K + +NCL L +AE + E+ +A + F A+ E + + +
Sbjct: 423 CVSFLEKQLTASNCLGVLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIA 482
Query: 180 FGRLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYIN---------LNAVSN 230
+ + +++L+ E+ +I W+ R +Y + + LN V N
Sbjct: 483 Y---VSNDSLNTKAEELVYETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDN 539
Query: 231 KTLVFASNKLVGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAH 290
+ L+ +S + N + ++ + + R L + + +V++GG++
Sbjct: 540 EELIKSSEACRDLVNEAKRYHMLPHARQEMQTPRTRPRL----SAGVAEVIVLVGGRQMV 595
Query: 291 GQFNDGVFAYII---QENLWMKLSDMP-YRAAALSATSAGRYIYISGGTTEQISGLKTAW 346
G + A Q N W L+ +P Y S SAG IY+SGG ++ L W
Sbjct: 596 GMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSVVSAGDNIYLSGGMESGVT-LADVW 654
Query: 347 RYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGG 382
Y ++W + + + H + G +Y++GG
Sbjct: 655 CYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYTLGG 690
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 115 bits (288), Expect = 1e-25
Identities = 115/508 (22%), Positives = 208/508 (40%), Gaps = 71/508 (13%)
Query: 4 EFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMK 63
E T+ +Y +L+ L++ R+ D+ + F H++V+A+ S +++
Sbjct: 49 ELTDASYGPNLLEGLSKMRQENFLCDLVIGTKTKSFDVHKSVMASCSEYFYNILKK---- 104
Query: 64 TADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDF 123
D +D + +SP+ + ++ Y Y+GK+ +S + ++ A Y L C+DF
Sbjct: 105 --DPSIQRVDLNDISPLGLATVIAYAYTGKLTLSLYTIGSIISAAVYLQIHTLVKMCSDF 162
Query: 124 LIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRL 183
LI+ + NC+ + +AE + LK A IRDNF +A S FM+ L
Sbjct: 163 LIREMSVENCMYVVNIAETYSLKNAKAAAQKFIRDNFLEFAE---SDQFMKLTFEQINEL 219
Query: 184 LRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLV-FASNKLVG 242
L D++L + +E A + W+ F + R KY + I +S + LV + +
Sbjct: 220 LIDDDLQLPSEIVAFQIAMKWLEF-DQKRVKYAADLLSNIRFGTISAQDLVNYVQSVPRM 278
Query: 243 MENTSSHTTLIESV---LMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFN-DGVF 298
M++ H L++++ L+ Q S R G + +V +GG+ + +
Sbjct: 279 MQDADCHRLLVDAMNYHLLPYHQNTLQSRRTRIRGGCRV--LVTVGGRPGLTEKSLSRDI 336
Query: 299 AYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQIS------GLKTAWRYDMDD 352
Y EN W KL++MP ++ ++Y++GG + + + RYD
Sbjct: 337 LYRDPENGWSKLTEMPAKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDPRF 396
Query: 353 NSWTKLPDLPIGLVFHTMVTCGGTVYSVGG------------------------------ 382
N+W L + ++ G VY+ GG
Sbjct: 397 NTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEVAR 456
Query: 383 -----SIAPRR------YVSNIY-----RYDERKEVWCLAGKMSIPMDGTAVITKGDRHL 426
++A R Y++N Y YD + W +S P +T DR +
Sbjct: 457 CCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDR-V 515
Query: 427 YIVTGRCL-VKGYISRVGVVDCFDTSTG 453
Y++ G L +G V V+C+ +TG
Sbjct: 516 YVMGGSQLGPRGERVDVLTVECYSPATG 543
Score = 43.5 bits (101), Expect = 5e-04
Identities = 41/156 (26%), Positives = 63/156 (40%), Gaps = 9/156 (5%)
Query: 281 VVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPY-RAAALSATSAGRYIYISGGTTEQI 339
V GG+ A G + Y+ N W + + R SA + GR + G
Sbjct: 421 VYAAGGRNAEGSLAS-LECYVPSTNQWQPKTPLEVARCCHASAVADGRVLVTGGYIANAY 479
Query: 340 SGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGS-IAPRRY---VSNIYR 395
S ++ YD +SW +LP+L +H VT VY +GGS + PR V +
Sbjct: 480 S--RSVCAYDPASDSWQELPNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVEC 537
Query: 396 YDERKEVWCLAGKMSIPMDGTAVITKGDRHLYIVTG 431
Y W A + + + TA ++ Y+V G
Sbjct: 538 YSPATGQWSYAAPLQVGV-STAGVSALHGRAYLVGG 572
Score = 34.3 bits (77), Expect = 0.33
Identities = 38/183 (20%), Positives = 71/183 (38%), Gaps = 15/183 (8%)
Query: 214 KYFKKFFNYINLNAVSNKTLVFASNKLVGM------ENTSSHTTLIESVLMDRKQERPCS 267
+Y +F +I+L +++ K F+ + G+ N +E + Q +P +
Sbjct: 391 RYDPRFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKT 450
Query: 268 LLVYQR---KGALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATS 324
L R A+ D V++ G ++ V AY + W +L ++ A +
Sbjct: 451 PLEVARCCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVT 510
Query: 325 AGRYIYISGGTT-----EQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYS 379
+Y+ GG+ E++ L T Y W+ L +G+ + G Y
Sbjct: 511 LSDRVYVMGGSQLGPRGERVDVL-TVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYL 569
Query: 380 VGG 382
VGG
Sbjct: 570 VGG 572
>gi|194097389 kelch-like 38 [Homo sapiens]
Length = 581
Score = 115 bits (288), Expect = 1e-25
Identities = 104/458 (22%), Positives = 199/458 (43%), Gaps = 31/458 (6%)
Query: 3 LEFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDM 62
L F + +++S +L+ LN R+ + D+++ HRNVLA+ SP R++ S+
Sbjct: 9 LLFKDHDFSSDLLRQLNSLRQSRILTDVSICAGAREIPCHRNVLASSSPYFRAMFCSSFR 68
Query: 63 KTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCND 122
+ ++ + + P T+DQ++ Y Y+G+ I+ NV ++ A P+L C+
Sbjct: 69 EKSEA---KVQLKGIDPPTLDQIVSYVYTGEAHIATDNVLPVMEAASMLQFPKLFEACSS 125
Query: 123 FLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGR 182
+L + +NCL + L+E+ + + A +F A+ S +
Sbjct: 126 YLQSQLAPSNCLGMIRLSEILSCETLKKKAREVALTSFPEVAA---SADLKELCALELRD 182
Query: 183 LLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINL---------NAVSNKTL 233
L D+ L E++ AL+ W+ + R++Y ++ F + L + ++N L
Sbjct: 183 YLGDDGL-CGEEEKVFEALMVWIKHDLQARKRYMQELFKQVRLQYIHPAFFHHFIANDAL 241
Query: 234 VFASNKLVGMENTSSHT--TLIESVLMDRKQERPCSLLVY-QRKGALLDSVVILGGQKAH 290
+ +S + T+ +L + + D C LL++ + + D +++LGG+K
Sbjct: 242 LQSSPACQIILETAKRQMFSLCGTTVPD------CKLLLHVPPRNSYQDFLILLGGRKDS 295
Query: 291 GQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLK----TAW 346
Q V Y Q W L+ +P R SA + R IY+ GG SG +
Sbjct: 296 QQTTRDVLLYSKQTGQWQSLAKLPTRLYKASAITLHRSIYVLGGMAVS-SGRSLVSHNVY 354
Query: 347 RYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLA 406
+ + N W + + H ++S+GG + + ++ RYD VW
Sbjct: 355 IFSLKLNQWRLGEPMLVARYSHRSTAHKNFIFSIGGIGEGQELMGSMERYDSICNVWESM 414
Query: 407 GKMSIPMDGTAVITKGDRHLYIVTGRCLVKGYISRVGV 444
M + + AV K D+ LY+ G +++ + + V
Sbjct: 415 ASMPVGVLHPAVAVK-DQRLYLFGGEDIMQNPVRLIQV 451
Score = 40.8 bits (94), Expect = 0.004
Identities = 30/98 (30%), Positives = 47/98 (47%), Gaps = 10/98 (10%)
Query: 279 DSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGG---T 335
+ +VI+GG + + AY Q N ++K +DM R AT G +Y++GG T
Sbjct: 479 ERIVIVGG------YTRRILAYDPQSNKFVKCADMKDRRMHHGATVMGNKLYVTGGRRLT 532
Query: 336 TE-QISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVT 372
T+ I + YD + ++WT LP L H +T
Sbjct: 533 TDCNIEDSASFDCYDPETDTWTSQGQLPHKLFDHACLT 570
Score = 36.6 bits (83), Expect = 0.066
Identities = 31/129 (24%), Positives = 45/129 (34%), Gaps = 18/129 (13%)
Query: 300 YIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLP 359
Y I N W K+ + A G I I GG T +I YD N + K
Sbjct: 452 YHISRNSWFKMETRMIKNVCAPAVVLGERIVIVGGYTRRILA------YDPQSNKFVKCA 505
Query: 360 DLPIGLVFHTMVTCGGTVYSVGGSIAPRRYV--------SNIYRYDERKEVWCLAGKMSI 411
D+ + H G +Y GG RR ++ YD + W G++
Sbjct: 506 DMKDRRMHHGATVMGNKLYVTGG----RRLTTDCNIEDSASFDCYDPETDTWTSQGQLPH 561
Query: 412 PMDGTAVIT 420
+ A +T
Sbjct: 562 KLFDHACLT 570
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 113 bits (282), Expect = 6e-25
Identities = 103/457 (22%), Positives = 195/457 (42%), Gaps = 18/457 (3%)
Query: 5 FTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKT 64
F N+ + + + K+ D+ L + AHR VL++VS ++ + ND++
Sbjct: 151 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFT-NDVRE 209
Query: 65 ADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFL 124
A + I ++ + P ++ L+ Y Y+G++ + E N+E LL A ++ C FL
Sbjct: 210 ARQEEIKMEG--VEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFL 267
Query: 125 IKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLL 184
+K + +NCL A+ ++ VA++ ++F + F+ P +LL
Sbjct: 268 MKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHF---MEVIRNQEFVLLPASEIAKLL 324
Query: 185 RDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGME 244
+++++ NE+ L+AL+ WV E R K K YI L ++ + L N ++ +
Sbjct: 325 ASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRD 384
Query: 245 NTSSHTTLIESV---LMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAYI 301
+ ++E++ L+ ++ S RK + + G G + Y
Sbjct: 385 DIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGA--TSIEKYD 442
Query: 302 IQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDL 361
++ N+W +++M R +Y+ GG + + L T Y+ +W+ +P +
Sbjct: 443 LRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-RDGLKTLNTVECYNPKTKTWSVMPPM 501
Query: 362 PIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITK 421
+ G +Y+VGG Y++ + R+D + W MS P V
Sbjct: 502 STHRHGLGVAVLEGPMYAVGGHDG-WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 560
Query: 422 GDRHLYIVTGRCLVKGYISRVGVVDCFDTSTGDVVQC 458
+ LY V GR S + V+CFD T C
Sbjct: 561 SGK-LYAVGGR----DGSSCLKSVECFDPHTNKWTLC 592
Score = 46.2 bits (108), Expect = 8e-05
Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 7/134 (5%)
Query: 303 QENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLP 362
Q W ++ M + + +Y GG + S LK+ +D N WT +
Sbjct: 538 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR-DGSSCLKSVECFDPHTNKWTLCAQMS 596
Query: 363 IGLVFHTMVTCGGTVYSVGGSIAPRRYVSN-----IYRYDERKEVWCLAGKMSIPMDGTA 417
+ T G +Y++GG AP +++ + RYD + ++W MSI D
Sbjct: 597 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 656
Query: 418 VITKGDRHLYIVTG 431
V GD+ LY V G
Sbjct: 657 VCLLGDK-LYAVGG 669
Score = 40.8 bits (94), Expect = 0.004
Identities = 28/121 (23%), Positives = 47/121 (38%), Gaps = 6/121 (4%)
Query: 305 NLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAW-----RYDMDDNSWTKLP 359
N W + M R + T+ +Y GG S L + RYD + WT +
Sbjct: 587 NKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVA 646
Query: 360 DLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVI 419
+ I + G +Y+VGG + Y++ + YD + W + + G V+
Sbjct: 647 SMSISRDAVGVCLLGDKLYAVGGYDG-QAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVV 705
Query: 420 T 420
T
Sbjct: 706 T 706
Score = 34.7 bits (78), Expect = 0.25
Identities = 42/182 (23%), Positives = 73/182 (40%), Gaps = 14/182 (7%)
Query: 204 WVYFRKEDREKYFKKFFNYINLNAVSNKTLVFA--SNKL--VGMENTSSHTTLIESVLMD 259
W Y +R + +N++ + T+ A S KL VG + SS +E
Sbjct: 526 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPH 585
Query: 260 RKQERPCSLLVYQRKGALLDS----VVILGGQKAHG-----QFNDGVFAYIIQENLWMKL 310
+ C+ + +R G + + + +GG A + +D V Y + ++W +
Sbjct: 586 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV 645
Query: 311 SDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTM 370
+ M A+ G +Y GG Q + L T YD N WT++ L +G +
Sbjct: 646 ASMSISRDAVGVCLLGDKLYAVGGYDGQ-AYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 704
Query: 371 VT 372
VT
Sbjct: 705 VT 706
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 113 bits (282), Expect = 6e-25
Identities = 103/457 (22%), Positives = 195/457 (42%), Gaps = 18/457 (3%)
Query: 5 FTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKT 64
F N+ + + + K+ D+ L + AHR VL++VS ++ + ND++
Sbjct: 197 FQALNHAEQTFKKMENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFT-NDVRE 255
Query: 65 ADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFL 124
A + I ++ + P ++ L+ Y Y+G++ + E N+E LL A ++ C FL
Sbjct: 256 ARQEEIKMEG--VEPNSLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFL 313
Query: 125 IKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLL 184
+K + +NCL A+ ++ VA++ ++F + F+ P +LL
Sbjct: 314 MKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHF---MEVIRNQEFVLLPASEIAKLL 370
Query: 185 RDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGME 244
+++++ NE+ L+AL+ WV E R K K YI L ++ + L N ++ +
Sbjct: 371 ASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLLAPQFLADMENNVLFRD 430
Query: 245 NTSSHTTLIESV---LMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAYI 301
+ ++E++ L+ ++ S RK + + G G + Y
Sbjct: 431 DIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGA--TSIEKYD 488
Query: 302 IQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDL 361
++ N+W +++M R +Y+ GG + + L T Y+ +W+ +P +
Sbjct: 489 LRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-RDGLKTLNTVECYNPKTKTWSVMPPM 547
Query: 362 PIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITK 421
+ G +Y+VGG Y++ + R+D + W MS P V
Sbjct: 548 STHRHGLGVAVLEGPMYAVGGHDG-WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 606
Query: 422 GDRHLYIVTGRCLVKGYISRVGVVDCFDTSTGDVVQC 458
+ LY V GR S + V+CFD T C
Sbjct: 607 SGK-LYAVGGR----DGSSCLKSVECFDPHTNKWTLC 638
Score = 46.2 bits (108), Expect = 8e-05
Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 7/134 (5%)
Query: 303 QENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLP 362
Q W ++ M + + +Y GG + S LK+ +D N WT +
Sbjct: 584 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR-DGSSCLKSVECFDPHTNKWTLCAQMS 642
Query: 363 IGLVFHTMVTCGGTVYSVGGSIAPRRYVSN-----IYRYDERKEVWCLAGKMSIPMDGTA 417
+ T G +Y++GG AP +++ + RYD + ++W MSI D
Sbjct: 643 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 702
Query: 418 VITKGDRHLYIVTG 431
V GD+ LY V G
Sbjct: 703 VCLLGDK-LYAVGG 715
Score = 40.8 bits (94), Expect = 0.004
Identities = 28/121 (23%), Positives = 47/121 (38%), Gaps = 6/121 (4%)
Query: 305 NLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAW-----RYDMDDNSWTKLP 359
N W + M R + T+ +Y GG S L + RYD + WT +
Sbjct: 633 NKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVA 692
Query: 360 DLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVI 419
+ I + G +Y+VGG + Y++ + YD + W + + G V+
Sbjct: 693 SMSISRDAVGVCLLGDKLYAVGGYDG-QAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVV 751
Query: 420 T 420
T
Sbjct: 752 T 752
Score = 34.7 bits (78), Expect = 0.25
Identities = 42/182 (23%), Positives = 73/182 (40%), Gaps = 14/182 (7%)
Query: 204 WVYFRKEDREKYFKKFFNYINLNAVSNKTLVFA--SNKL--VGMENTSSHTTLIESVLMD 259
W Y +R + +N++ + T+ A S KL VG + SS +E
Sbjct: 572 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPH 631
Query: 260 RKQERPCSLLVYQRKGALLDS----VVILGGQKAHG-----QFNDGVFAYIIQENLWMKL 310
+ C+ + +R G + + + +GG A + +D V Y + ++W +
Sbjct: 632 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV 691
Query: 311 SDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTM 370
+ M A+ G +Y GG Q + L T YD N WT++ L +G +
Sbjct: 692 ASMSISRDAVGVCLLGDKLYAVGGYDGQ-AYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 750
Query: 371 VT 372
VT
Sbjct: 751 VT 752
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 111 bits (277), Expect = 2e-24
Identities = 128/578 (22%), Positives = 221/578 (38%), Gaps = 51/578 (8%)
Query: 3 LEFTEKNYNSFVLQNLNRQRKRKEYWDMAL-SVDNHVFFAHRNVLAAVSPLVRSLISSND 61
L F++ + +L+ L++ R +++ D+ L + F AHR VLAA SP R++ +
Sbjct: 10 LPFSDPAHALSLLRGLSQLRAERKFLDVTLEAAGGRDFPAHRAVLAAASPYFRAMFAGQL 69
Query: 62 MKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCN 121
++ E + + P + LLD+ Y+G+V +S N E LLR A P ++ C
Sbjct: 70 RESRAE---RVRLHGVPPDMLQLLLDFSYTGRVAVSGDNAEPLLRAADLLQFPAVKEACG 126
Query: 122 DFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFG 181
FL + + ANCL AE F ++ A I + G+ R P
Sbjct: 127 AFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRFILRH----VGELGAEQLERLPLARLL 182
Query: 182 RLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLV--FASNK 239
R LRD+ L V E+ A + WV R ++ + + L V L+ +
Sbjct: 183 RYLRDDGLCVPKEEAAYQLALRWVRADPPRRAAHWPQLLEAVRLPFVRRFYLLAHVEAEP 242
Query: 240 LVG----MENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFND 295
LV ++ DR PC + + L + +V++GG
Sbjct: 243 LVARCPPCLRLLREARDFQAARYDRHDRGPCPRMRPRPSTGLAEILVLVGGCDQDCDELV 302
Query: 296 GVFAYIIQENLWMKLSDMP-YRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNS 354
V Y Q W L++ P + S + G IY++GG ++ WRY+ N
Sbjct: 303 TVDCYNPQTGQWRYLAEFPDHLGGGYSIVALGNDIYVTGG-SDGSRLYDCVWRYNSSVNE 361
Query: 355 WTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMD 414
W ++ + +H+ G +Y V + RYD + W M+ PMD
Sbjct: 362 WAEVAPMLKAREYHSSSVLDGLLYVVA--------ADSTERYDHTTDSWEALQPMTYPMD 413
Query: 415 GTAVITKGDRHLYIVTGRCLVKGYIS--RVGVVDCFDTSTG--DVVQCITFPIEFNHRPL 470
+ GR G ++ V+ C+D T +V C P ++ P
Sbjct: 414 NCSTTA--------CRGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLP-PWSFAPK 464
Query: 471 LSFQQDNILCVHSHRQSVEINLQKVKASKTTTSVPVLPNSCPLDVSHAICSIGDSKVFVC 530
+ + V V++ + T +P+ + V ++ +G K++V
Sbjct: 465 TATLNGLMYFVRDDSAEVDV------YNPTRNEWDKIPSMNQVHVGGSLAVLG-GKLYVS 517
Query: 531 GGVTTASDVQTKDYTINPNAFLLDQKTGKWKTLAPPPE 568
GG + ++ D +T W + PE
Sbjct: 518 GGYDNT-------FELSDVVEAYDPETRAWSVVGRLPE 548
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 110 bits (276), Expect = 3e-24
Identities = 105/424 (24%), Positives = 176/424 (41%), Gaps = 18/424 (4%)
Query: 15 LQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITIDT 74
L+ +N RK +E D+ L V +AHR +L+A SP R++ + ++ + D
Sbjct: 55 LEVINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRD- 113
Query: 75 SYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANCL 134
+ ++ L+D+ Y+ ++ + E NV+ LL A ++ C +FL + + +NCL
Sbjct: 114 --IDERAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCL 171
Query: 135 RYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVLNE 194
A+ +E+ +A + NF E FM P ++ + L+V +E
Sbjct: 172 GIRAFADTHSCRELLRIADKFTQHNFQEVMESE---EFMLLPANQLIDIISSDELNVRSE 228
Query: 195 DQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLV--FASNKLVGMENTSSHTTL 252
+Q +A++ WV + ++R + ++ L +S K LV S+ L+ +
Sbjct: 229 EQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVD 288
Query: 253 IESVLMDRKQERPC--SLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKL 310
+ QERP RK V+ G G V Y Q N W +
Sbjct: 289 EAKNYLLLPQERPLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMV 348
Query: 311 SDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTM 370
+ M R + + +Y GG + S L + RYD N W+ D+ T
Sbjct: 349 ASMSKRRCGVGVSVLDDLLYAVGG-HDGSSYLNSVERYDPKTNQWSS--DVAPTSTCRTS 405
Query: 371 V---TCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITKGDRHLY 427
V GG +Y+VGG ++ + RYD ++ W MS G AV G LY
Sbjct: 406 VGVAVLGGFLYAVGGQDGV-SCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGG-FLY 463
Query: 428 IVTG 431
V G
Sbjct: 464 AVGG 467
Score = 36.2 bits (82), Expect = 0.086
Identities = 36/137 (26%), Positives = 54/137 (39%), Gaps = 8/137 (5%)
Query: 280 SVVILGGQKAHGQFNDG------VFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISG 333
+V +LGG +DG V Y QEN W ++ M R L IY G
Sbjct: 454 AVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVG 513
Query: 334 GTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNI 393
G + + L +A RY+ N W+ + + + G + +VGG Y+ I
Sbjct: 514 G-RDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGG-FDGTTYLKTI 571
Query: 394 YRYDERKEVWCLAGKMS 410
+D W L G M+
Sbjct: 572 EVFDPDANTWRLYGGMN 588
>gi|21362105 BTB/POZ KELCH domain protein [Homo sapiens]
Length = 589
Score = 110 bits (274), Expect = 5e-24
Identities = 105/466 (22%), Positives = 193/466 (41%), Gaps = 39/466 (8%)
Query: 5 FTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKT 64
F + ++ VL +LN RK + D+ L + F HR VLAA S ++ S ++
Sbjct: 23 FHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRES 82
Query: 65 ADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFL 124
D+ D L P ++ LLD+ YS ++ I+E+N E LL +R +FL
Sbjct: 83 RDDTVNFQDN--LHPEVLELLLDFAYSSRIAINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Query: 125 IKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLL 184
K++ +NCL + L++ + + + + ++ R ++ + S F L+
Sbjct: 141 EKNLFPSNCLGMMLLSDAHQCRRLYEFSW---RMCLVHFETVRQSEDFNSLSKDTLLDLI 197
Query: 185 RDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINL---------NAVSNKTLVF 235
+ L +E A++ WV E R+ + + + L AVS++ L+
Sbjct: 198 SSDELETEDERVVFEAILQWVKHDLEPRKVHLPELLRSVRLALLPSDCLQEAVSSEALLM 257
Query: 236 AS--NKLVGMENTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQF 293
A KL+ E T ++++ D PC+ R +++ILGGQ
Sbjct: 258 ADERTKLIMDEALRCKTRILQN---DGVVTSPCA-----RPRKAGHTLLILGGQTF---M 306
Query: 294 NDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDN 353
D ++ + + +D+P SA++ G +Y++GG + K W YD
Sbjct: 307 CDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHE 366
Query: 354 SWTKLPDLPIGLVFHTMVTCGGTVYSVGG--------SIAPRRYVSNIYRYDERKEVWCL 405
W+K + I H +Y VGG +P + + +YD W +
Sbjct: 367 EWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGVFPASPSVSLKQVEKYDPGANKWMM 426
Query: 406 AGKMSIPMDGTAVITKGDRHLYIVTGRCLVKGYISRVGVVDCFDTS 451
+ + AV++ L++ G + + +S+ V C+D S
Sbjct: 427 VAPLRDGVSNAAVVS-AKLKLFVFGGTSIHRDMVSK---VQCYDPS 468
Score = 53.5 bits (127), Expect = 5e-07
Identities = 33/121 (27%), Positives = 52/121 (42%), Gaps = 3/121 (2%)
Query: 283 ILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGL 342
+ GG H V Y EN W ++ P +A G I+I GG TE +
Sbjct: 448 VFGGTSIHRDMVSKVQCYDPSENRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAA- 506
Query: 343 KTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEV 402
+A+R+D + N WT++ D+ + + G +Y VGG +R + YD +
Sbjct: 507 -SAYRFDCETNQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQR-CKTLDCYDPTSDT 564
Query: 403 W 403
W
Sbjct: 565 W 565
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 109 bits (273), Expect = 6e-24
Identities = 99/402 (24%), Positives = 168/402 (41%), Gaps = 30/402 (7%)
Query: 14 VLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITID 73
+L L R R + + D+ L V HR +LA SP ++ + + A+ ++
Sbjct: 1 MLDGLQRLRSQPKLADVTLLVGGRELPCHRGLLALSSPYFHAMFAGD---FAESFSARVE 57
Query: 74 TSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANC 133
+ P V QL+D+ Y+G++ I++ NVE L R A + P ++ C +L + + ANC
Sbjct: 58 LRDVEPAVVGQLVDFVYTGRLTITQGNVEALTRTAARLHFPSVQKVCGRYLQQQLDAANC 117
Query: 134 LRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVLN 193
L E L V+ A++ +R+NF A + F++ P L + L V
Sbjct: 118 LGICEFGEQQGLLGVAAKAWAFLRENFEAVARED---EFLQLPRERLVTCLAGDLLQVQP 174
Query: 194 EDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGMENTSSHTTLI 253
E L AL+ WV + R + + + ++L+AV + +L+ E +
Sbjct: 175 EQSRLEALMRWVRHDPQARAAHLPELLSLVHLDAVPRPCV----QQLLASEPLIQESEAC 230
Query: 254 ESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFND-------GVFA-YIIQEN 305
+ L P +L Q+K L + +V++GGQ + G FA Y +
Sbjct: 231 RAALSQGHDGAPLAL---QQK--LEEVLVVVGGQALEEEEAGEEPTPGLGNFAFYNSKAK 285
Query: 306 LWMKLSDMP-YRAAALSATSAGRYIYISG---GTTEQISGLKTAWRYDMDDNSWTKLPDL 361
WM L D P Y S + IY++G GT AW + + + SW + +
Sbjct: 286 RWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPM 345
Query: 362 PIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVW 403
H G +Y +GG+ V + YD + W
Sbjct: 346 LKPRTNHASAALNGEIYVIGGTTLD---VVEVESYDPYTDSW 384
>gi|38327518 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 107 bits (266), Expect = 4e-23
Identities = 96/404 (23%), Positives = 174/404 (43%), Gaps = 32/404 (7%)
Query: 8 KNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADE 67
+++ +L L R++ ++D + + + + HR VLAA S R++ N MK D+
Sbjct: 32 EDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVN-MKERDD 90
Query: 68 LFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKS 127
+TI LS V LDY Y+GK I++ NVE + + + L C+DFLIKS
Sbjct: 91 GSVTITN--LSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKS 148
Query: 128 ICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDE 187
I NCL+ L +++ + + D A ++ H+++ S F+ + + L +
Sbjct: 149 INLVNCLQLLSISDSYGSTSLFDHALHFVQ---HHFSLLFKSSDFLEMNFGVLQKCLESD 205
Query: 188 NLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGMENTS 247
L+V E+ L +++W E R+KY + L+ +S +TL + L E+
Sbjct: 206 ELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETL---QDCLFNEESLL 262
Query: 248 SHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQENLW 307
T + ++ K + L + + + + + + +G+ N F Y I+ + W
Sbjct: 263 KSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGE-NQYTFCYNIKSDSW 321
Query: 308 -----MKLSDMPYRAAALSATSAGRYIYISGGTTEQIS---GLKTAWRY-DMDDNSWTKL 358
L D+P S +S G I+++GG + L A Y D D +W
Sbjct: 322 KILPQSHLIDLP----GSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYC 377
Query: 359 P---------DLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNI 393
P + HT V ++ +GG R + ++
Sbjct: 378 PVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSL 421
>gi|38327516 BTB and kelch domain containing 3 [Homo sapiens]
Length = 612
Score = 107 bits (266), Expect = 4e-23
Identities = 96/404 (23%), Positives = 174/404 (43%), Gaps = 32/404 (7%)
Query: 8 KNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADE 67
+++ +L L R++ ++D + + + + HR VLAA S R++ N MK D+
Sbjct: 32 EDHGQKILSVLQNFREQNVFYDFKIIMKDEIIPCHRCVLAACSDFFRAMFEVN-MKERDD 90
Query: 68 LFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKS 127
+TI LS V LDY Y+GK I++ NVE + + + L C+DFLIKS
Sbjct: 91 GSVTITN--LSSKAVKAFLDYAYTGKTKITDDNVEMFFQLSSFLQVSFLSKACSDFLIKS 148
Query: 128 ICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDE 187
I NCL+ L +++ + + D A ++ H+++ S F+ + + L +
Sbjct: 149 INLVNCLQLLSISDSYGSTSLFDHALHFVQ---HHFSLLFKSSDFLEMNFGVLQKCLESD 205
Query: 188 NLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGMENTS 247
L+V E+ L +++W E R+KY + L+ +S +TL + L E+
Sbjct: 206 ELNVPEEEMVLKVVLSWTKHNLESRQKYLPHLIEKVRLHQLSEETL---QDCLFNEESLL 262
Query: 248 SHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQENLW 307
T + ++ K + L + + + + + + +G+ N F Y I+ + W
Sbjct: 263 KSTNCFDIIMDAIKCVQGSGGLFPDARPSTTEKYIFIHKTEENGE-NQYTFCYNIKSDSW 321
Query: 308 -----MKLSDMPYRAAALSATSAGRYIYISGGTTEQIS---GLKTAWRY-DMDDNSWTKL 358
L D+P S +S G I+++GG + L A Y D D +W
Sbjct: 322 KILPQSHLIDLP----GSSLSSYGEKIFLTGGCKGKCCRTVRLHIAESYHDATDQTWCYC 377
Query: 359 P---------DLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNI 393
P + HT V ++ +GG R + ++
Sbjct: 378 PVKNDFFLVSTMKTPRTMHTSVMALDRLFVIGGKTRGSRDIKSL 421
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 105 bits (262), Expect = 1e-22
Identities = 111/480 (23%), Positives = 187/480 (38%), Gaps = 65/480 (13%)
Query: 7 EKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTAD 66
E+ ++ + N R + D+ + V+ F AH+N+L + S R+L +S T
Sbjct: 18 ERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEK 77
Query: 67 ELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIK 126
+++ + +SP + +++Y Y+ V I+ NVE+LL A FN + C +FL
Sbjct: 78 KVY---NIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKS 134
Query: 127 SICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRD 186
+C NC+ + + E+ AY I NF + S F+ ++
Sbjct: 135 ELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMV--KVSAEFLELSVTELKDIIEK 192
Query: 187 ENLHVLNEDQALSALINWVYFRKEDREKYFK--------------------KFFNYI--- 223
+ L+V ED A++ W+ ++R+++ K +Y+
Sbjct: 193 DELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDS 252
Query: 224 -----------------NLNAVSNK---------TLVFASNKLVGMENTSSHTTLIES-- 255
N+N SN L +A +G + S T IE+
Sbjct: 253 EECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYD 312
Query: 256 VLMDRKQERPC---SLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSD 312
DR C S Y L V I+GG + FN V + + W +++
Sbjct: 313 ARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFN-SVKRFDPVKKTWHQVAP 371
Query: 313 MPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVT 372
M R +S T G +IY GG + L TA RY+ + N WT + + + T
Sbjct: 372 MHSRRCYVSVTVLGNFIYAMGGFDGYVR-LNTAERYEPETNQWTLIAPMHEQRSDASATT 430
Query: 373 CGGTVYSVGGSIAPR-RYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITKGDRHLYIVTG 431
G VY GG + + +Y + + W + M G VI G+ H+Y V G
Sbjct: 431 LYGKVYICGGFNGNECLFTAEVYNTESNQ--WTVIAPMRSRRSGIGVIAYGE-HVYAVGG 487
Score = 35.8 bits (81), Expect = 0.11
Identities = 27/112 (24%), Positives = 48/112 (42%), Gaps = 2/112 (1%)
Query: 300 YIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLP 359
Y + N W ++ M R + + + G ++Y GG + + L++A Y N+W +P
Sbjct: 453 YNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGG-FDGANRLRSAEAYSPVANTWRTIP 511
Query: 360 DLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSI 411
+ + ++ VGG N+ YDE+ + W A MSI
Sbjct: 512 TMFNPRSNFGIEVVDDLLFVVGG-FNGFTTTFNVECYDEKTDEWYDAHDMSI 562
>gi|11545731 gigaxonin [Homo sapiens]
Length = 597
Score = 105 bits (261), Expect = 2e-22
Identities = 84/395 (21%), Positives = 173/395 (43%), Gaps = 14/395 (3%)
Query: 14 VLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITID 73
+L+ L+ R+ + D L +D +N+LAA SP +R+ ++ N K + I+
Sbjct: 16 LLRALSSFREESRFCDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPKDDGSTY-KIE 74
Query: 74 TSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANC 133
+S + + ++LDY +SG++ ++E ++++++ A L+ C +FL I NC
Sbjct: 75 LEGISVMVMREILDYIFSGQIRLNEDTIQDVVQAADLLLLTDLKTLCCEFLEGCIAAENC 134
Query: 134 LRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVLN 193
+ A + L V +A + +F +S E F+ P ++ E L+V N
Sbjct: 135 IGIRDFALHYCLHHVHYLATEYLETHFRDVSSTE---EFLELSPQKLKEVISLEKLNVGN 191
Query: 194 EDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGMENTSSHTTLI 253
E A+I W+ E R+ + K + + ++ + + + +++
Sbjct: 192 ERYVFEAVIRWIAHDTEIRKVHMKDVMSALWVSGLDSS---YLREQMLNEPLVREIVKEC 248
Query: 254 ESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVF-----AYIIQENLWM 308
++ + + Q+ L ++ +G + +V +GG++ + Y LW+
Sbjct: 249 SNIPLSQPQQGEAMLANFKPRG-YSECIVTVGGEERVSRKPTAAMRCMCPLYDPNRQLWI 307
Query: 309 KLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFH 368
+L+ + SA ++++ GG E L + +YD D N+WT LP +
Sbjct: 308 ELAPLSMPRINHGVLSAEGFLFVFGGQDENKQTLSSGEKYDPDANTWTALPPMNEARHNF 367
Query: 369 TMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVW 403
+V G +Y +GG + +S + YD + W
Sbjct: 368 GIVEIDGMLYILGGEDGEKELIS-MECYDIYSKTW 401
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 103 bits (258), Expect = 3e-22
Identities = 96/419 (22%), Positives = 181/419 (43%), Gaps = 18/419 (4%)
Query: 43 RNVLAAVSPLVRSLISSNDMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVE 102
R VL++VS ++ + ND++ A + I ++ + P ++ L+ Y Y+G++ + E N+E
Sbjct: 174 RLVLSSVSDYFAAMFT-NDVREARQEEIKMEG--VEPNSLWSLIQYAYTGRLELKEDNIE 230
Query: 103 ELLRGAQYFNTPRLRVHCNDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHY 162
LL A ++ C FL+K + +NCL A+ ++ VA++ ++F
Sbjct: 231 CLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHF-- 288
Query: 163 WASPEGSMHFMRCPPVIFGRLLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNY 222
+ F+ P +LL +++++ NE+ L+AL+ WV E R K K Y
Sbjct: 289 -MEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAY 347
Query: 223 INLNAVSNKTLVFASNKLVGMENTSSHTTLIESV---LMDRKQERPCSLLVYQRKGALLD 279
I L ++ + L N ++ ++ ++E++ L+ ++ S RK +
Sbjct: 348 IRLPLLAPQFLADMENNVLFRDDIECQKLIMEAMKYHLLPERRPMLQSPRTKPRKSTVGT 407
Query: 280 SVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQI 339
+ G G + Y ++ N+W +++M R +Y+ GG + +
Sbjct: 408 LFAVGGMDSTKGA--TSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGG-RDGL 464
Query: 340 SGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDER 399
L T Y+ +W+ +P + + G +Y+VGG Y++ + R+D +
Sbjct: 465 KTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDG-WSYLNTVERWDPQ 523
Query: 400 KEVWCLAGKMSIPMDGTAVITKGDRHLYIVTGRCLVKGYISRVGVVDCFDTSTGDVVQC 458
W MS P V + LY V GR S + V+CFD T C
Sbjct: 524 ARQWNFVATMSTPRSTVGVAVLSGK-LYAVGGR----DGSSCLKSVECFDPHTNKWTLC 577
Score = 46.2 bits (108), Expect = 8e-05
Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 7/134 (5%)
Query: 303 QENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLP 362
Q W ++ M + + +Y GG + S LK+ +D N WT +
Sbjct: 523 QARQWNFVATMSTPRSTVGVAVLSGKLYAVGGR-DGSSCLKSVECFDPHTNKWTLCAQMS 581
Query: 363 IGLVFHTMVTCGGTVYSVGGSIAPRRYVSN-----IYRYDERKEVWCLAGKMSIPMDGTA 417
+ T G +Y++GG AP +++ + RYD + ++W MSI D
Sbjct: 582 KRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVG 641
Query: 418 VITKGDRHLYIVTG 431
V GD+ LY V G
Sbjct: 642 VCLLGDK-LYAVGG 654
Score = 40.8 bits (94), Expect = 0.004
Identities = 28/121 (23%), Positives = 47/121 (38%), Gaps = 6/121 (4%)
Query: 305 NLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAW-----RYDMDDNSWTKLP 359
N W + M R + T+ +Y GG S L + RYD + WT +
Sbjct: 572 NKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVA 631
Query: 360 DLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVI 419
+ I + G +Y+VGG + Y++ + YD + W + + G V+
Sbjct: 632 SMSISRDAVGVCLLGDKLYAVGGYDG-QAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVV 690
Query: 420 T 420
T
Sbjct: 691 T 691
Score = 34.7 bits (78), Expect = 0.25
Identities = 42/182 (23%), Positives = 73/182 (40%), Gaps = 14/182 (7%)
Query: 204 WVYFRKEDREKYFKKFFNYINLNAVSNKTLVFA--SNKL--VGMENTSSHTTLIESVLMD 259
W Y +R + +N++ + T+ A S KL VG + SS +E
Sbjct: 511 WSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPH 570
Query: 260 RKQERPCSLLVYQRKGALLDS----VVILGGQKAHG-----QFNDGVFAYIIQENLWMKL 310
+ C+ + +R G + + + +GG A + +D V Y + ++W +
Sbjct: 571 TNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAV 630
Query: 311 SDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTM 370
+ M A+ G +Y GG Q + L T YD N WT++ L +G +
Sbjct: 631 ASMSISRDAVGVCLLGDKLYAVGGYDGQ-AYLNTVEAYDPQTNEWTQVAPLCLGRAGACV 689
Query: 371 VT 372
VT
Sbjct: 690 VT 691
>gi|40255071 kelch-like 23 [Homo sapiens]
Length = 558
Score = 103 bits (257), Expect = 4e-22
Identities = 105/407 (25%), Positives = 179/407 (43%), Gaps = 31/407 (7%)
Query: 38 VFFAHRNVLAAVSPLVRSLISSNDMKTADELFITIDTSYLSPVTVDQLLDYFYSGKVVIS 97
+F HR VLAA S +++ ++ DMK ++ I S + ++ L++Y Y+ ++ I+
Sbjct: 47 IFHCHRAVLAACSNYFKAMFTA-DMK--EKFKNKIKLSGIHHDILEGLVNYAYTSQIEIT 103
Query: 98 EQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANCLRYLFLAELFELKEVSDVAYSGIR 157
++NV+ LL A ++ C FL++ + NC+ AE E+ + +
Sbjct: 104 KRNVQSLLEAADLLQFLSVKKACERFLVRHLDIDNCIGMHSFAEFHVCPELEKESRRILC 163
Query: 158 DNF-HYWASPEGSMHFMRCPPVIFGRLLRDENLHVLNEDQALSALINWVYFRKEDREKYF 216
F W E F+ F +L +NL V E+ + +I W E+R +
Sbjct: 164 SKFKEVWQQEE----FLEISLEKFLFILSRKNLSVWKEEAIIEPVIKWTAHDVENRIECL 219
Query: 217 KKFFNYINLNA--VSNKTLVFASNKLVGMENTSSHTTLIESVLMDRKQERPCSLLVYQRK 274
+YIN++ V KT + + EN +LI + L +E + QR
Sbjct: 220 YNLLSYINIDIDPVYLKTALGLQRSCLLTENKIR--SLIYNALNPMHKE------ISQRS 271
Query: 275 GALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMP-YRAAALSATSAGRYIYISG 333
A ++ I+GG H ++ + N+W++ +++P Y + T G IY++G
Sbjct: 272 TA---TMYIIGGYYWHPLSEVHIWDPLT--NVWIQGAEIPDYTRESYGVTCLGPNIYVTG 326
Query: 334 G-TTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGG--SIAPRRYV 390
G T+ I L T W Y+ + + WT+ + +H VT GG VY++GG AP
Sbjct: 327 GYRTDNIEALDTVWIYNSESDEWTEGLPMLNARYYHCAVTLGGCVYALGGYRKGAP---A 383
Query: 391 SNIYRYDERKEVWCLAGKMSIPMDGTAVITKGDRHLYIVTGRCLVKG 437
YD KE W M I G A +Y++ G C +G
Sbjct: 384 EEAEFYDPLKEKWIPIANM-IKGVGNATACVLHDVIYVIGGHCGYRG 429
Score = 38.9 bits (89), Expect = 0.013
Identities = 32/140 (22%), Positives = 55/140 (39%), Gaps = 9/140 (6%)
Query: 277 LLDSVVILGGQKAH--GQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGG 334
L D + ++GG + D V +Y N W ++ P+ L + +Y+ GG
Sbjct: 414 LHDVIYVIGGHCGYRGSCTYDKVQSYNSDINEWSLITSSPHPEYGLCSVPFENKLYLVGG 473
Query: 335 TTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGG-SIAPRRYVSNI 393
T YD + N W ++ + + V G +Y GG S + Y+ +I
Sbjct: 474 QT------TITECYDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSI 527
Query: 394 YRYDERKEVWCLAGKMSIPM 413
+YD W + G + M
Sbjct: 528 EKYDPDLNKWEIVGNLPSAM 547
Score = 33.1 bits (74), Expect = 0.73
Identities = 20/73 (27%), Positives = 36/73 (49%), Gaps = 1/73 (1%)
Query: 300 YIIQENLWMKLSDMPYRAAALSATSAGRYIYISGG-TTEQISGLKTAWRYDMDDNSWTKL 358
Y ++N W +++ M R A IY++GG + + + L++ +YD D N W +
Sbjct: 481 YDPEQNEWREIAPMMERRMECGAVIMNGCIYVTGGYSYSKGTYLQSIEKYDPDLNKWEIV 540
Query: 359 PDLPIGLVFHTMV 371
+LP + H V
Sbjct: 541 GNLPSAMRSHGCV 553
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 103 bits (256), Expect = 6e-22
Identities = 94/403 (23%), Positives = 171/403 (42%), Gaps = 23/403 (5%)
Query: 14 VLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSN--DMKTADELFIT 71
+LQ LN R+ E D+ L V + AH+ VLA+VSP +++ + N + + ++ F
Sbjct: 21 LLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQC 80
Query: 72 IDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRA 131
ID + L + ++Y Y+G V IS+ VE LL A + C FL +
Sbjct: 81 IDETALQAI-----VEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPG 135
Query: 132 NCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHV 191
NC+ AE + +++ A I NF E F ++ ++ L+V
Sbjct: 136 NCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTE---EFFELTHADLDEIVSNDCLNV 192
Query: 192 LNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNK--TLVFASNKLVGMENTSSH 249
E+ AL +W+ + ++R+KY + N + L +S K T ++ +N L+ + T H
Sbjct: 193 ATEETVFYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKH 252
Query: 250 TTLIESVLMDRKQERPCS--LLVYQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQENLW 307
L E++ E S ++ R + +GG+ D V Y Q + W
Sbjct: 253 -LLNEALKYHFMPEHRLSHQTVLMTRPRCAPKVLCAVGGKSGLFACLDSVEMYFPQNDSW 311
Query: 308 MKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYD-------MDDNSWTKLPD 360
+ L+ + + +Y+ GG + T +++ D N+WT L
Sbjct: 312 IGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLER 371
Query: 361 LPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVW 403
+ +V G +Y++GG + Y+ ++ +Y + W
Sbjct: 372 MNESRSTLGVVVLAGELYALGG-YDGQSYLQSVEKYIPKIRKW 413
Score = 43.1 bits (100), Expect = 7e-04
Identities = 42/161 (26%), Positives = 67/161 (41%), Gaps = 13/161 (8%)
Query: 278 LDSVVILGGQKAHGQFN-----DGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYIS 332
L VV+ G A G ++ V YI + W ++ M + +A IY
Sbjct: 379 LGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAI 438
Query: 333 GGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSN 392
GG + + + RYD +SW + + + + G ++ VGG ++S+
Sbjct: 439 GGYGP--AHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS-HLSS 495
Query: 393 IYRYDERKEVWCLAGKMSIPMD--GTAVITKGDRHLYIVTG 431
I RYD + W + M P G AVI D +LY+V G
Sbjct: 496 IERYDPHQNQWTVCRPMKEPRTGVGAAVI---DNYLYVVGG 533
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 102 bits (254), Expect = 1e-21
Identities = 122/572 (21%), Positives = 228/572 (39%), Gaps = 37/572 (6%)
Query: 4 EFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMK 63
+F N+ L+ + K K+ D+ L + AHR VL+AVS ++ +++ ++
Sbjct: 158 QFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLE 217
Query: 64 TADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDF 123
E + + P ++ L+ Y Y+G + + E +E LL A ++ C++F
Sbjct: 218 AKQE---EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNF 274
Query: 124 LIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRL 183
LIK + +NCL + E+ +VA+ ++F + F+ P +L
Sbjct: 275 LIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHF---IEVIKNQEFLLLPANEISKL 331
Query: 184 LRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGM 243
L ++++V +E+ AL+ WV ++R+ +YI L + + L +
Sbjct: 332 LCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFT 391
Query: 244 ENTSSHTTLIESVLMDRKQERPCSLLVYQRK--GALLDSVVILGGQKAHGQFNDGVFAYI 301
+ L+E++ ER + + K + + ++ +GG A + + Y
Sbjct: 392 GDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAM-KGTTTIEKYD 450
Query: 302 IQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDL 361
++ N W+ + M R +Y+ GG + + L T ++ WT +P +
Sbjct: 451 LRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG-RDGLKTLNTVECFNPVGKIWTVMPPM 509
Query: 362 PIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITK 421
+ T G +Y+VGG Y++ + R+D W MS P V+
Sbjct: 510 STHRHGLGVATLEGPMYAVGGHDG-WSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
Query: 422 GDRHLYIVTGRCLVKGYISRVGVVDCFDTSTGDVVQCITFP--------IEFNHRPLLSF 473
++ LY + GR S + ++ FD T C +N +
Sbjct: 569 NNK-LYAIGGR----DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVG 623
Query: 474 QQDNILCVHSHRQSVEINLQKVKASKTTTSVPVLPNSCPLDVSHAICSIGDSKVFVCGGV 533
D H R S + K +T V P S P D + A+C +GD K++V GG
Sbjct: 624 GHDAPASNHCSRLSDCVERYDPKGDSWST---VAPLSVPRD-AVAVCPLGD-KLYVVGGY 678
Query: 534 TTASDVQTKDYTINPNAFLLDQKTGKWKTLAP 565
+ + T + D + +WK P
Sbjct: 679 DGHTYLNTVE--------SYDAQRNEWKEEVP 702
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 102 bits (253), Expect = 1e-21
Identities = 117/539 (21%), Positives = 218/539 (40%), Gaps = 29/539 (5%)
Query: 4 EFTEKNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMK 63
+F N+ L+ + K K+ D+ L + AHR VL+AVS ++ +++ ++
Sbjct: 158 QFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLE 217
Query: 64 TADELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDF 123
E + + P ++ L+ Y Y+G + + E +E LL A ++ C++F
Sbjct: 218 AKQE---EVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNF 274
Query: 124 LIKSICRANCLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRL 183
LIK + +NCL + E+ +VA+ ++F + F+ P +L
Sbjct: 275 LIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHF---IEVIKNQEFLLLPANEISKL 331
Query: 184 LRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGM 243
L ++++V +E+ AL+ WV ++R+ +YI L + + L +
Sbjct: 332 LCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADLETSSMFT 391
Query: 244 ENTSSHTTLIESVLMDRKQERPCSLLVYQRK--GALLDSVVILGGQKAHGQFNDGVFAYI 301
+ L+E++ ER + + K + + ++ +GG A + + Y
Sbjct: 392 GDLECQKLLMEAMKYHLLPERRSMMQSPRTKPRKSTVGALYAVGGMDAM-KGTTTIEKYD 450
Query: 302 IQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDL 361
++ N W+ + M R +Y+ GG + + L T ++ WT +P +
Sbjct: 451 LRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGG-RDGLKTLNTVECFNPVGKIWTVMPPM 509
Query: 362 PIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITK 421
+ T G +Y+VGG Y++ + R+D W MS P V+
Sbjct: 510 STHRHGLGVATLEGPMYAVGGHDG-WSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVAL 568
Query: 422 GDRHLYIVTGRCLVKGYISRVGVVDCFDTSTGDVVQCITFP--------IEFNHRPLLSF 473
++ LY + GR S + ++ FD T C +N +
Sbjct: 569 NNK-LYAIGGR----DGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVG 623
Query: 474 QQDNILCVHSHRQSVEINLQKVKASKTTTSVPVLPNSCPLDVSHAICSIGDSKVFVCGG 532
D H R S + K +T V P S P D + A+C +GD K++V GG
Sbjct: 624 GHDAPASNHCSRLSDCVERYDPKGDSWST---VAPLSVPRD-AVAVCPLGD-KLYVVGG 677
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 100 bits (248), Expect = 5e-21
Identities = 95/427 (22%), Positives = 175/427 (40%), Gaps = 25/427 (5%)
Query: 14 VLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITID 73
V++ + RQ K D+ L + +H F AHR VLAA P ++ +++ M+ + +
Sbjct: 27 VMEEIRRQGK---LCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVM-- 81
Query: 74 TSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANC 133
+ P ++ L+++ Y+G + I +QNV+ LL GA + ++ C FL + + NC
Sbjct: 82 -QGMDPSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNC 140
Query: 134 LRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVLN 193
L AE + D A S I +F S F+ P L+ + L+V +
Sbjct: 141 LGVRQFAETMMCAVLYDAANSFIHQHF---VEVSMSEEFLALPLEDVLELVSRDELNVKS 197
Query: 194 EDQALSALINWVYFRKEDREKYFKKFFNYINL---------NAVSNKTLVFASNKLVGME 244
E+Q A + WV + +E R Y + + I L + V LV +K +
Sbjct: 198 EEQVFEAALAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLV 257
Query: 245 NTSSHTTLIESVLMDRKQERPCSLLVYQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQE 304
+ + L + +R+ P + ++ + +GG + G + V +
Sbjct: 258 DEAKDYHL----MPERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIA 313
Query: 305 NLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIG 364
N W + M + + +Y GG Q+ L T Y+ + ++WT++ +
Sbjct: 314 NCWERCRPMTTARSRVGVAVVNGLLYAIGGYDGQLR-LSTVEAYNPETDTWTRVGSMNSK 372
Query: 365 LVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITKGDR 424
V G +Y GG +S++ Y + W + MS A +T +
Sbjct: 373 RSAMGTVVLDGQIYVCGG-YDGNSSLSSVETYSPETDKWTVVTSMS-SNRSAAGVTVFEG 430
Query: 425 HLYIVTG 431
+Y+ G
Sbjct: 431 RIYVSGG 437
>gi|156616301 kelch-like 32 [Homo sapiens]
Length = 620
Score = 99.8 bits (247), Expect = 6e-21
Identities = 101/418 (24%), Positives = 181/418 (43%), Gaps = 35/418 (8%)
Query: 8 KNYNSFVLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKT-AD 66
+++N VL LN+QR D+ L + F AH+ VLAA S R++ S +++ AD
Sbjct: 22 ESHNDSVLAALNQQRSDGILCDITLIAEEQKFHAHKAVLAACSDYFRAMFSLCMVESGAD 81
Query: 67 ELFITIDTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIK 126
E ++ ++ + + Q L++ Y+G++++ ++++L + L C+ +LI+
Sbjct: 82 E----VNLHGVTSLGLKQALEFAYTGQILLEPGVIQDVLAAGSHLQLLELLNLCSHYLIQ 137
Query: 127 SICRANCLRYLFLAELFEL----KEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGR 182
+ N L LA+LF L K V D + + + PE + P +
Sbjct: 138 ELNSFNYLDLYRLADLFNLTLLEKAVIDFLVKHLSELLK--SRPE---EVLTLPYCLLQE 192
Query: 183 LLRDENLHVLNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTL--VFASNKL 240
+L+ + L L+E+Q + W+ +Y + YI + TL V S+ L
Sbjct: 193 VLKSDRLTSLSEEQIWQLAVRWL--EHNCHYQYMDELLQYIRFGLMDVDTLHTVALSHPL 250
Query: 241 VGMENTSSHTTLIESVLMDRKQ--ERPCSLLVYQRKGALLDSVVILGGQKAH-------G 291
V T+ T L+ L + +P + D++ I+GG+K
Sbjct: 251 VQASETA--TALVNEALEYHQSIYAQPVWQTRRTKPRFQSDTLYIIGGKKREVCKVKELR 308
Query: 292 QFN--DGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISG----LKTA 345
FN D A I W +L+ MP + G +++++GG E SG ++TA
Sbjct: 309 YFNPVDQENALIAAIANWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHASGRTCAVRTA 368
Query: 346 WRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVW 403
RYD NSW ++ + + +Y+VGG R+ + + RY +K W
Sbjct: 369 CRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKW 426
Score = 37.0 bits (84), Expect = 0.051
Identities = 24/109 (22%), Positives = 44/109 (40%)
Query: 275 GALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGG 334
GA+ + + +GG+ Q V Y ++N W + + + A ++ISGG
Sbjct: 394 GAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGG 453
Query: 335 TTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGS 383
T Y+ + N W + V+H+M +Y +GG+
Sbjct: 454 VTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGN 502
>gi|227497736 T-cell activation kelch repeat protein [Homo sapiens]
Length = 601
Score = 99.4 bits (246), Expect = 8e-21
Identities = 120/533 (22%), Positives = 209/533 (39%), Gaps = 78/533 (14%)
Query: 14 VLQNLNRQRKRKEYWDMALSVDN-HVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITI 72
+L+ L + D+ + VD+ F HRNVLAA+SP RS+ +S ++ + +
Sbjct: 35 ILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIV 94
Query: 73 DTSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRAN 132
S +D +L+Y Y+ +V+++E NV+ L A F P ++ C ++I + N
Sbjct: 95 GVEAES---MDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQN 151
Query: 133 CLRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVL 192
+ A+ + +E+ D + IR F F++ +L ++L+V
Sbjct: 152 SIGVFIFADHYGHQELGDRSKEYIRKKF---LCVTKEQEFLQLTKDQLISILDSDDLNVD 208
Query: 193 NEDQALSALINWVYFRKEDREKYFKKFF-----------NYINLNAVSNKTLVFASNKLV 241
E+ ++I W + +RE + + F +I + S
Sbjct: 209 REEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEK 268
Query: 242 GMENTSSHT-----TLIESVL--------MDRKQERPCSLLVYQRKGALL---------- 278
G NT+ T T E ++ +KQ PC +V R L
Sbjct: 269 GPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVG 328
Query: 279 ------DSVVILGGQKA--------HGQFNDGVFAYIIQENLWM-KLSDMPYRAAALSAT 323
+ + I GG + H ND + Y N W+ K S + R
Sbjct: 329 ILVSPDNDIYIAGGYRPSSSEVSIDHKAEND-FWMYDHSTNRWLSKPSLLRARIGCKLVY 387
Query: 324 SAGRYIYISGGTTEQISG---LKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSV 380
G+ +Y GG + G LK+ YD +N WT + +P+ + FH V +Y +
Sbjct: 388 CCGK-MYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVL 446
Query: 381 GGSIAPRRYVSNIYRYDERKEVWCLAGKMSIP-MDGTAVITKGDRHLYIVTGRCLVKGYI 439
G Y+ +K+ W M++P + G A + K +Y + G C G
Sbjct: 447 QGEF--------FLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDS--IYYIAGTC---GNH 493
Query: 440 SRVGVVDCFDTSTGDVVQCITFPIEFNHRP---LLSFQQDNILCVHSHRQSVE 489
R+ V+ +D + FP + + P L+ FQ L V + + +VE
Sbjct: 494 QRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVE 546
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 97.1 bits (240), Expect = 4e-20
Identities = 92/412 (22%), Positives = 173/412 (41%), Gaps = 12/412 (2%)
Query: 23 KRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITIDTSYLSPVTV 82
K+++ D+ L V N AHR VL++VS ++ +S+ + E I + P +
Sbjct: 207 KQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQE---EIKMEGIDPNAL 263
Query: 83 DQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANCLRYLFLAEL 142
L+ + Y+G + + E +E LL A P++ C FL+K + +NCL A+
Sbjct: 264 WDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADA 323
Query: 143 FELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVLNEDQALSALI 202
E+ VA+S +N + F+ P +LL ++++V +E+ AL+
Sbjct: 324 QGCIELMKVAHSYTMENI---MEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALM 380
Query: 203 NWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGMENTSSHTTLIESVLMDRKQ 262
WV + + R +I L + + L N + + ++E++
Sbjct: 381 MWVKYDMQSRCNDLSMLLAFIRLPLLPPQILADLENHALFKNDLECQKLILEAMKYHLLP 440
Query: 263 ERPCSLLVYQRK--GALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAAL 320
ER + + K + + ++ +GG + + + Y ++ NLW++ M R
Sbjct: 441 ERRTLMQSPRTKPRKSTVGTLYAVGGMD-NNKGATTIEKYDLRTNLWIQAGMMNGRRLQF 499
Query: 321 SATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSV 380
+++ GG + + L T Y+ +WT LP + + G +Y+V
Sbjct: 500 GVAVIDDKLFVIGG-RDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAV 558
Query: 381 GGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITKGDRHLYIVTGR 432
GG Y++ + R+D + + W MSI V + LY V GR
Sbjct: 559 GGHDG-WSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGK-LYSVGGR 608
Score = 53.1 bits (126), Expect = 7e-07
Identities = 37/134 (27%), Positives = 56/134 (41%), Gaps = 7/134 (5%)
Query: 303 QENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLP 362
Q W ++ M + + + +Y GG + S L + YD N W +
Sbjct: 576 QSQQWTFVASMSIARSTVGVAALNGKLYSVGGR-DGSSCLSSMEYYDPHTNKWNMCAPMC 634
Query: 363 IGLVFHTMVTCGGTVYSVGGSIAPR-----RYVSNIYRYDERKEVWCLAGKMSIPMDGTA 417
+ TC G +Y+VGG AP R + + RYD + + W + +S+P D
Sbjct: 635 KRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVG 694
Query: 418 VITKGDRHLYIVTG 431
V GDR LY V G
Sbjct: 695 VCLLGDR-LYAVGG 707
Score = 30.0 bits (66), Expect = 6.2
Identities = 20/70 (28%), Positives = 30/70 (42%), Gaps = 1/70 (1%)
Query: 295 DGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNS 354
D V Y + + W ++ + A+ G +Y GG Q + L T YD N
Sbjct: 668 DYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQ-TYLNTMESYDPQTNE 726
Query: 355 WTKLPDLPIG 364
WT++ L IG
Sbjct: 727 WTQMASLNIG 736
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 95.1 bits (235), Expect = 2e-19
Identities = 97/436 (22%), Positives = 165/436 (37%), Gaps = 58/436 (13%)
Query: 18 LNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITIDTSYL 77
+N RK+K D+ L V AHR VLAA S + ++N +++ ++
Sbjct: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKS---FEVELKDA 90
Query: 78 SPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANCLRYL 137
P ++QL+++ Y+ ++ ++ NV+ LL A + ++ C DFL + + +NCL
Sbjct: 91 EPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGIS 150
Query: 138 FLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVLNEDQA 197
LAE + E+ A I +F + F++ LL + L V EDQ
Sbjct: 151 VLAECLDCPELKATADDFIHQHF---TEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 207
Query: 198 LSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTL------------------VFASNK 239
A + W+ + + +R+ + + +S L + S
Sbjct: 208 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGM 267
Query: 240 LVGMENTSSHTTLIESVLMDRKQ----------ERPCSLLVYQRKG-------------- 275
+ + L++ RK+ +P S + K
Sbjct: 268 RYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRR 327
Query: 276 ----ALLDSVV-ILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIY 330
D+VV ILGG + + Y + ++ W P +L+A +A IY
Sbjct: 328 DAACVFWDNVVYILGGSQLFP--IKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIY 385
Query: 331 ISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPR--- 387
SGG+ S L YD SW P + H MV G +Y GGS+
Sbjct: 386 TSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSG 445
Query: 388 RYVSNIYRYDERKEVW 403
R +++ YD E W
Sbjct: 446 RVLNSCEVYDPATETW 461
Score = 38.1 bits (87), Expect = 0.023
Identities = 26/100 (26%), Positives = 45/100 (45%), Gaps = 6/100 (6%)
Query: 279 DSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQ 338
D + +GGQ G D V Y I+ N W +S MP++ + + G +Y+ G +
Sbjct: 481 DKIFAVGGQNGLGGL-DNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAG-FQG 538
Query: 339 ISGLKTAWRYDMDDNSW---TKLPDLPIGLVFHTMV-TCG 374
+ L Y+ + + W +K+ P+ +V TCG
Sbjct: 539 VGRLGHILEYNTETDKWVANSKVRAFPVTSCLICVVDTCG 578
Score = 31.2 bits (69), Expect = 2.8
Identities = 31/125 (24%), Positives = 48/125 (38%), Gaps = 8/125 (6%)
Query: 300 YIIQENLWMKLSDMPYRAAALSATSAGRYIYISGGTT-EQISG--LKTAWRYDMDDNSWT 356
Y + W M + + A IY+ GG+ +SG L + YD +WT
Sbjct: 403 YDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWT 462
Query: 357 KLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGT 416
+L + H +V +++VGG + N+ YD + W KM PM
Sbjct: 463 ELCPMIEARKNHGLVFVKDKIFAVGGQNG-LGGLDNVEYYDIKLNEW----KMVSPMPWK 517
Query: 417 AVITK 421
V K
Sbjct: 518 GVTVK 522
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 95.1 bits (235), Expect = 2e-19
Identities = 92/413 (22%), Positives = 174/413 (42%), Gaps = 16/413 (3%)
Query: 14 VLQNLNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITID 73
+L ++N RK D+ L V+ F AHR VLAA S ++ +S + +D
Sbjct: 19 ILNSMNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPY---VD 75
Query: 74 TSYLSPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANC 133
L+ T++ LLD+ Y+ V ++ +NV+ELL A ++ C +FL + +NC
Sbjct: 76 IQGLTASTMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 135
Query: 134 LRYLFLAELFELKEVSDVAYSGIRDNFHYWASPEGSMH--FMRCPPVIFGRLLRDENLHV 191
L AE ++ A + +F PE H F+ +L++ + + V
Sbjct: 136 LGIRDFAETHNCVDLMQAAEVFSQKHF-----PEVVQHEEFILLSQGEVEKLIKCDEIQV 190
Query: 192 LNEDQALSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGMENTSSHTT 251
+E+ A+INWV K++RE+ Y+ + ++ + + + + +
Sbjct: 191 DSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRD 250
Query: 252 LIESVLMDRKQERPCSLLVYQRKGALL---DSVVILGGQKAHGQFNDGVFAYIIQENLWM 308
L++ + S + R A L + ++++GG + D V Y + W
Sbjct: 251 LVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWS 310
Query: 309 KLSDMPYRAAALSATSAGRYIYISGG--TTEQISGLKTAWRYDMDDNSWTKLPDLPIGLV 366
L + + +++ S IY+ GG ++S ++ +D W + + +
Sbjct: 311 FLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRG 370
Query: 367 FHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVI 419
T G +Y GG RR+ S + RYD + W + G M +G ++
Sbjct: 371 LAGATTLGDMIYVSGGFDGSRRHTS-MERYDPNIDQWSMLGDMQTAREGAGLV 422
Score = 52.8 bits (125), Expect = 9e-07
Identities = 40/163 (24%), Positives = 67/163 (41%), Gaps = 5/163 (3%)
Query: 271 YQRKGALLDSVVILGGQKAHGQFND-GVFAYIIQEN-LWMKLSDMPYRAAALSATSAGRY 328
Y +L D + ++GG + + Y E+ +W ++ M R AT+ G
Sbjct: 321 YVASVSLHDRIYVIGGYDGRSRLSSVECLDYTADEDGVWYSVAPMNVRRGLAGATTLGDM 380
Query: 329 IYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRR 388
IY+SGG RYD + + W+ L D+ +V G +Y +GG
Sbjct: 381 IYVSGGFDGSRRHTSME-RYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGG-YDGLN 438
Query: 389 YVSNIYRYDERKEVWCLAGKMSIPMDGTAVITKGDRHLYIVTG 431
++++ +YD W M+ G V D H+Y+V G
Sbjct: 439 ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLND-HIYVVGG 480
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 94.7 bits (234), Expect = 2e-19
Identities = 102/429 (23%), Positives = 182/429 (42%), Gaps = 35/429 (8%)
Query: 18 LNRQRKRKEYWDMALSVDNHVFFAHRNVLAAVSPLVRSLISSNDMKTADELFITIDTSYL 77
++R R+R D+ L V AH+ VLA+ SP ++ + N+M + + +T+ +
Sbjct: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFT-NEMSESRQTHVTLHD--I 138
Query: 78 SPVTVDQLLDYFYSGKVVISEQNVEELLRGAQYFNTPRLRVHCNDFLIKSICRANCLRYL 137
P +DQL+ + Y+ ++V+ E NV+ LL A +R C FL+ + +NCL
Sbjct: 139 DPQALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIR 198
Query: 138 FLAELFELKEVSDVAYSGIRDNFHYWASPEGSMHFMRCPPVIFGRLLRDENLHVLNEDQA 197
A+ ++ A+ + +F A E FM P L+ ++L+V +E++
Sbjct: 199 GFADAHSCSDLLKAAHRYVLQHFVDVAKTE---EFMLLPLKQVLELVSSDSLNVPSEEEV 255
Query: 198 LSALINWVYFRKEDREKYFKKFFNYINLNAVSNKTLVFASNKLVGMENTSSHTTLIESVL 257
A+++WV + R ++ + + L +S L+ V E+ H + +L
Sbjct: 256 YRAVLSWVKHDVDARRQHVPRLMKCVRLPLLSRDFLL----GHVDAESLVRHHPDCKDLL 311
Query: 258 MDRKQERPCSLLVYQRKGALLDS-------------VVILGGQKAHGQFNDGVFAYIIQE 304
++ + L+ +++G L S + +GG D AY +
Sbjct: 312 IEALKFH----LLPEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGD-CEAYDTRT 366
Query: 305 NLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIG 364
+ W ++ M R A + + G +Y GG + S L T YD N+W P++ +G
Sbjct: 367 DRWHVVASMSTRRARVGVAAVGNRLYAVGG-YDGTSDLATVESYDPVTNTWQ--PEVSMG 423
Query: 365 LVFHTM--VTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITKG 422
+ G +YS GG +++ RYD W MS V T
Sbjct: 424 TRRSCLGVAALHGLLYSAGG-YDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATL- 481
Query: 423 DRHLYIVTG 431
D +LY V G
Sbjct: 482 DGNLYAVGG 490
Score = 44.3 bits (103), Expect = 3e-04
Identities = 34/139 (24%), Positives = 60/139 (43%), Gaps = 3/139 (2%)
Query: 271 YQRKGALLDSVVILGGQKAHGQFNDGVFAYIIQENLWMKLSDMPYRAAALSATSAGRYIY 330
Y R L ++ +GG + V Y Q N+W ++ M R ++ +Y
Sbjct: 475 YVRVATLDGNLYAVGGYDSSSHLAT-VEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALY 533
Query: 331 ISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIGLVFHTMVTCGGTVYSVGGSIAPRRYV 390
++GG + S L + RY +W + + I H +V G +Y+VGG+ +
Sbjct: 534 VAGGN-DGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSS-L 591
Query: 391 SNIYRYDERKEVWCLAGKM 409
++I +Y+ R W A M
Sbjct: 592 NSIEKYNPRTNKWVAASCM 610
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/127 (23%), Positives = 55/127 (43%), Gaps = 3/127 (2%)
Query: 305 NLWMKLSDMPYRAAALSATSAGRYIYISGGTTEQISGLKTAWRYDMDDNSWTKLPDLPIG 364
N W M R + L + +Y +GG + S L +A RYD +WT + +
Sbjct: 414 NTWQPEVSMGTRRSCLGVAALHGLLYSAGGY-DGASCLNSAERYDPLTGTWTSVAAMSTR 472
Query: 365 LVFHTMVTCGGTVYSVGGSIAPRRYVSNIYRYDERKEVWCLAGKMSIPMDGTAVITKGDR 424
+ + T G +Y+VGG +++ + +Y+ + VW M + +A + +
Sbjct: 473 RRYVRVATLDGNLYAVGG-YDSSSHLATVEKYEPQVNVWSPVASM-LSRRSSAGVAVLEG 530
Query: 425 HLYIVTG 431
LY+ G
Sbjct: 531 ALYVAGG 537
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.418
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,913,244
Number of Sequences: 37866
Number of extensions: 926967
Number of successful extensions: 2478
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 45
Number of HSP's that attempted gapping in prelim test: 1871
Number of HSP's gapped (non-prelim): 374
length of query: 588
length of database: 18,247,518
effective HSP length: 108
effective length of query: 480
effective length of database: 14,157,990
effective search space: 6795835200
effective search space used: 6795835200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.