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Search of human proteins with 15967159
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|15967159 glucokinase isoform 2 [Homo sapiens]
(466 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|15967159 glucokinase isoform 2 [Homo sapiens] 931 0.0
gi|15967161 glucokinase isoform 3 [Homo sapiens] 905 0.0
gi|4503951 glucokinase isoform 1 [Homo sapiens] 902 0.0
gi|15553127 hexokinase 2 [Homo sapiens] 518 e-147
gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens] 503 e-142
gi|188497754 hexokinase 1 isoform HKI [Homo sapiens] 503 e-142
gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens] 503 e-142
gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens] 503 e-142
gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens] 503 e-142
gi|156151420 hexokinase domain containing 1 [Homo sapiens] 493 e-139
gi|194097330 hexokinase 3 [Homo sapiens] 474 e-134
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 33 0.72
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 31 2.7
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 30 6.1
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 30 6.1
gi|160948610 E3 ubiquitin-protein ligase UBR3 [Homo sapiens] 30 6.1
gi|117414143 hypothetical protein LOC55603 [Homo sapiens] 29 8.0
>gi|15967159 glucokinase isoform 2 [Homo sapiens]
Length = 466
Score = 931 bits (2406), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLP 60
MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLP
Sbjct: 1 MAMDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLP 60
Query: 61 TYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTA 120
TYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTA
Sbjct: 61 TYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTA 120
Query: 121 EMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGN 180
EMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGN
Sbjct: 121 EMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGN 180
Query: 181 NVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQ 240
NVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQ
Sbjct: 181 NVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQ 240
Query: 241 NVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMG 300
NVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMG
Sbjct: 241 NVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMG 300
Query: 301 ELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRP 360
ELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRP
Sbjct: 301 ELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRP 360
Query: 361 STTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSF 420
STTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSF
Sbjct: 361 STTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSF 420
Query: 421 KERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 466
KERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Sbjct: 421 KERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 466
>gi|15967161 glucokinase isoform 3 [Homo sapiens]
Length = 464
Score = 905 bits (2338), Expect = 0.0
Identities = 453/460 (98%), Positives = 454/460 (98%)
Query: 7 RSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 66
RSQ + VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST
Sbjct: 5 RSQLPQPNSQVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRST 64
Query: 67 PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDY 126
PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDY
Sbjct: 65 PEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDY 124
Query: 127 ISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLL 186
ISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLL
Sbjct: 125 ISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLL 184
Query: 187 RDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVE 246
RDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVE
Sbjct: 185 RDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVE 244
Query: 247 GDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLV 306
GDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLV
Sbjct: 245 GDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLV 304
Query: 307 LLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCD 366
LLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCD
Sbjct: 305 LLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCD 364
Query: 367 IVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHA 426
IVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHA
Sbjct: 365 IVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHA 424
Query: 427 SVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 466
SVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
Sbjct: 425 SVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ 464
>gi|4503951 glucokinase isoform 1 [Homo sapiens]
Length = 465
Score = 902 bits (2332), Expect = 0.0
Identities = 450/450 (100%), Positives = 450/450 (100%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL
Sbjct: 16 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 75
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD
Sbjct: 76 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 135
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF
Sbjct: 136 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 195
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT
Sbjct: 196 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 255
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL
Sbjct: 256 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 315
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS
Sbjct: 316 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 375
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE
Sbjct: 376 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 435
Query: 437 ITFIESEEGSGRGAALVSAVACKKACMLGQ 466
ITFIESEEGSGRGAALVSAVACKKACMLGQ
Sbjct: 436 ITFIESEEGSGRGAALVSAVACKKACMLGQ 465
>gi|15553127 hexokinase 2 [Homo sapiens]
Length = 917
Score = 518 bits (1333), Expect = e-147
Identities = 241/445 (54%), Positives = 338/445 (75%), Gaps = 2/445 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
V+Q L +L +E L ++ +R +KEM++GL TH A+VKMLPT+VRSTP+G+E G+FL
Sbjct: 22 VDQYLYHMRLSDETLLEISKRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFL 81
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGGTNFRV+ VKV + G V+ ++Q+Y+IPED M G+ LFD+I+EC+++F+D
Sbjct: 82 ALDLGGTNFRVLWVKVTDN--GLQKVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMD 139
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
K Q+K KKLPLGFTFSFP +D+ L++WTKGFK+SG EG +VV L+R AI+RRGDF
Sbjct: 140 KLQIKDKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVALIRKAIQRRGDF 199
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
++D+VA+VNDTV TM++C Y+DH CE+G+IVGTG NACYMEEM+++++VEGDEGRMC+N
Sbjct: 200 DIDIVAVVNDTVGTMMTCGYDDHNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINM 259
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD G L++ E+D+ +D S NPG+QL+EK+I G YMGELVRL+L+++ E LL
Sbjct: 260 EWGAFGDDGSLNDIRTEFDQEIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKEELL 319
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G+ S +L G FET+ +S +E + ++ +L LGL P+ DC R C+ VS
Sbjct: 320 FGGKLSPELLNTGRFETKDISDIEGEKDGIRKAREVLMRLGLDPTQEDCVATHRICQIVS 379
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
TR+A +C+A LA V+ R++E++ E+ +R T+GVDGSVYK HP F +R H +VRRL P C+
Sbjct: 380 TRSASLCAATLAAVLQRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKTVRRLVPGCD 439
Query: 437 ITFIESEEGSGRGAALVSAVACKKA 461
+ F+ SE+GSG+GAA+V+AVA + A
Sbjct: 440 VRFLRSEDGSGKGAAMVTAVAYRLA 464
Score = 516 bits (1329), Expect = e-146
Identities = 250/442 (56%), Positives = 334/442 (75%), Gaps = 2/442 (0%)
Query: 18 EQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLS 77
++ L QL + L +V RRM+ EM+RGL ETH A VKMLPTYV +TP+G+E GDFL+
Sbjct: 471 QKTLEHLQLSHDQLLEVKRRMKVEMERGLSKETHASAPVKMLPTYVCATPDGTEKGDFLA 530
Query: 78 LDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDK 137
LDLGGTNFRV+LV+V G+ G V+ +++Y+IP++ M GT + LFD+I +CI+DFL+
Sbjct: 531 LDLGGTNFRVLLVRVRNGKWG--GVEMHNKIYAIPQEVMHGTGDELFDHIVQCIADFLEY 588
Query: 138 HQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFE 197
MK LPLGFTFSFP + +D+ ILL WTKGFKASG EG +VV LL++AI RR +F+
Sbjct: 589 MGMKGVSLPLGFTFSFPCQQNSLDESILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFD 648
Query: 198 MDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTE 257
+DVVA+VNDTV TM++C +ED CEVG+IVGTG NACYMEEM+NVELVEG+EGRMCVN E
Sbjct: 649 LDVVAVVNDTVGTMMTCGFEDPHCEVGLIVGTGSNACYMEEMRNVELVEGEEGRMCVNME 708
Query: 258 WGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLF 317
WGAFGD+G LD+F E+D VDE S NPG+Q +EK+I G Y+GE+VR +L+ LLF
Sbjct: 709 WGAFGDNGCLDDFRTEFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLF 768
Query: 318 HGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVST 377
G SE+L+TRG FET+F+SQ+ESD Q+ IL LGL + D IV+ C V+
Sbjct: 769 RGRISERLKTRGIFETKFLSQIESDCLALLQVRAILQHLGLESTCDDSIIVKEVCTVVAR 828
Query: 378 RAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEI 437
RAA +C AG+A V++R+RE+R D +++TVGVDG++YKLHP F + H +V+ L P C++
Sbjct: 829 RAAQLCGAGMAAVVDRIRENRGLDALKVTVGVDGTLYKLHPHFAKVMHETVKDLAPKCDV 888
Query: 438 TFIESEEGSGRGAALVSAVACK 459
+F++SE+GSG+GAAL++AVAC+
Sbjct: 889 SFLQSEDGSGKGAALITAVACR 910
>gi|188497750 hexokinase 1 isoform HKI-td [Homo sapiens]
Length = 905
Score = 503 bits (1294), Expect = e-142
Identities = 243/443 (54%), Positives = 331/443 (74%), Gaps = 2/443 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
+E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+E GDFL
Sbjct: 458 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 517
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I CISDFLD
Sbjct: 518 ALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLD 575
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
+K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAIKRR +F
Sbjct: 576 YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEF 635
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G+MC+N
Sbjct: 636 DLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINM 695
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+ + L
Sbjct: 696 EWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFL 755
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ C VS
Sbjct: 756 FRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS 815
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+ L+P C
Sbjct: 816 RRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCN 875
Query: 437 ITFIESEEGSGRGAALVSAVACK 459
++F+ SE+GSG+GAAL++AV +
Sbjct: 876 VSFLLSEDGSGKGAALITAVGVR 898
Score = 474 bits (1219), Expect = e-134
Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GDF+
Sbjct: 10 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 69
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF++
Sbjct: 70 ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 127
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD+
Sbjct: 128 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 187
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
+ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 188 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 247
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E LL
Sbjct: 248 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 307
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C VS
Sbjct: 308 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 367
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P +
Sbjct: 368 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 427
Query: 437 ITFIESEEGSGRGAALVSAVACKKA 461
+ F+ SE GSG+GAA+V+AVA + A
Sbjct: 428 VRFLLSESGSGKGAAMVTAVAYRLA 452
>gi|188497754 hexokinase 1 isoform HKI [Homo sapiens]
Length = 917
Score = 503 bits (1294), Expect = e-142
Identities = 243/443 (54%), Positives = 331/443 (74%), Gaps = 2/443 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
+E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+E GDFL
Sbjct: 470 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 529
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I CISDFLD
Sbjct: 530 ALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLD 587
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
+K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAIKRR +F
Sbjct: 588 YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEF 647
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G+MC+N
Sbjct: 648 DLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINM 707
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+ + L
Sbjct: 708 EWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFL 767
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ C VS
Sbjct: 768 FRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS 827
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+ L+P C
Sbjct: 828 RRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCN 887
Query: 437 ITFIESEEGSGRGAALVSAVACK 459
++F+ SE+GSG+GAAL++AV +
Sbjct: 888 VSFLLSEDGSGKGAALITAVGVR 910
Score = 474 bits (1219), Expect = e-134
Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GDF+
Sbjct: 22 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 81
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF++
Sbjct: 82 ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 139
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD+
Sbjct: 140 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 199
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
+ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 200 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 259
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E LL
Sbjct: 260 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 319
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C VS
Sbjct: 320 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 379
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P +
Sbjct: 380 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 439
Query: 437 ITFIESEEGSGRGAALVSAVACKKA 461
+ F+ SE GSG+GAA+V+AVA + A
Sbjct: 440 VRFLLSESGSGKGAAMVTAVAYRLA 464
>gi|15991829 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
Length = 921
Score = 503 bits (1294), Expect = e-142
Identities = 243/443 (54%), Positives = 331/443 (74%), Gaps = 2/443 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
+E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+E GDFL
Sbjct: 474 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 533
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I CISDFLD
Sbjct: 534 ALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLD 591
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
+K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAIKRR +F
Sbjct: 592 YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEF 651
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G+MC+N
Sbjct: 652 DLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINM 711
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+ + L
Sbjct: 712 EWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFL 771
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ C VS
Sbjct: 772 FRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS 831
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+ L+P C
Sbjct: 832 RRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCN 891
Query: 437 ITFIESEEGSGRGAALVSAVACK 459
++F+ SE+GSG+GAAL++AV +
Sbjct: 892 VSFLLSEDGSGKGAALITAVGVR 914
Score = 474 bits (1219), Expect = e-134
Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GDF+
Sbjct: 26 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 85
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF++
Sbjct: 86 ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 143
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD+
Sbjct: 144 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 203
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
+ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 204 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 263
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E LL
Sbjct: 264 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 323
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C VS
Sbjct: 324 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 383
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P +
Sbjct: 384 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 443
Query: 437 ITFIESEEGSGRGAALVSAVACKKA 461
+ F+ SE GSG+GAA+V+AVA + A
Sbjct: 444 VRFLLSESGSGKGAAMVTAVAYRLA 468
>gi|15991831 hexokinase 1 isoform HKI-ta/tb [Homo sapiens]
Length = 921
Score = 503 bits (1294), Expect = e-142
Identities = 243/443 (54%), Positives = 331/443 (74%), Gaps = 2/443 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
+E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+E GDFL
Sbjct: 474 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 533
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I CISDFLD
Sbjct: 534 ALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLD 591
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
+K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAIKRR +F
Sbjct: 592 YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEF 651
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G+MC+N
Sbjct: 652 DLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINM 711
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+ + L
Sbjct: 712 EWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFL 771
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ C VS
Sbjct: 772 FRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS 831
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+ L+P C
Sbjct: 832 RRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCN 891
Query: 437 ITFIESEEGSGRGAALVSAVACK 459
++F+ SE+GSG+GAAL++AV +
Sbjct: 892 VSFLLSEDGSGKGAALITAVGVR 914
Score = 474 bits (1219), Expect = e-134
Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GDF+
Sbjct: 26 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 85
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF++
Sbjct: 86 ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 143
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD+
Sbjct: 144 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 203
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
+ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 204 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 263
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E LL
Sbjct: 264 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 323
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C VS
Sbjct: 324 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 383
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P +
Sbjct: 384 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 443
Query: 437 ITFIESEEGSGRGAALVSAVACKKA 461
+ F+ SE GSG+GAA+V+AVA + A
Sbjct: 444 VRFLLSESGSGKGAAMVTAVAYRLA 468
>gi|15991827 hexokinase 1 isoform HKI-R [Homo sapiens]
Length = 916
Score = 503 bits (1294), Expect = e-142
Identities = 243/443 (54%), Positives = 331/443 (74%), Gaps = 2/443 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
+E+ LA F L ++ L +V +RM+ EM+ GLR +TH A VKMLP++VR TP+G+E GDFL
Sbjct: 469 IEETLAHFHLTKDMLLEVKKRMRAEMELGLRKQTHNNAVVKMLPSFVRRTPDGTENGDFL 528
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGGTNFRV+LVK+ G++ +V+ +++Y+IP + M GT E LFD+I CISDFLD
Sbjct: 529 ALDLGGTNFRVLLVKIRSGKKR--TVEMHNKIYAIPIEIMQGTGEELFDHIVSCISDFLD 586
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
+K ++PLGFTFSFP + +D GIL+ WTKGFKA+ G++VV LLRDAIKRR +F
Sbjct: 587 YMGIKGPRMPLGFTFSFPCQQTSLDAGILITWTKGFKATDCVGHDVVTLLRDAIKRREEF 646
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
++DVVA+VNDTV TM++C YE+ CEVG+IVGTG NACYMEEM+NVE+VEGD+G+MC+N
Sbjct: 647 DLDVVAVVNDTVGTMMTCAYEEPTCEVGLIVGTGSNACYMEEMKNVEMVEGDQGQMCINM 706
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD+G LD+ YDRLVDE S N G+Q YEK+I G Y+GE+VR +L+ + L
Sbjct: 707 EWGAFGDNGCLDDIRTHYDRLVDEYSLNAGKQRYEKMISGMYLGEIVRNILIDFTKKGFL 766
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G+ SE L+TRG FET+F+SQ+ESD Q+ IL LGL + D +V+ C VS
Sbjct: 767 FRGQISETLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVS 826
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
RAA +C AG+A V++++RE+R D + +TVGVDG++YKLHP F H +V+ L+P C
Sbjct: 827 RRAAQLCGAGMAAVVDKIRENRGLDRLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCN 886
Query: 437 ITFIESEEGSGRGAALVSAVACK 459
++F+ SE+GSG+GAAL++AV +
Sbjct: 887 VSFLLSEDGSGKGAALITAVGVR 909
Score = 474 bits (1219), Expect = e-134
Identities = 222/445 (49%), Positives = 320/445 (71%), Gaps = 2/445 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
+++ L +L +E L +M R +KEM GL + + A+VKMLPT+VRS P+GSE GDF+
Sbjct: 21 IDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSEKGDFI 80
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
+LDLGG++FR++ V+V E +V + ++Y PE+ + G+ LFD+++EC+ DF++
Sbjct: 81 ALDLGGSSFRILRVQVNH--EKNQNVHMESEVYDTPENIVHGSGSQLFDHVAECLGDFME 138
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
K ++K KKLP+GFTFSFP + ID+ IL+ WTK FKASG EG +VV LL AIK+RGD+
Sbjct: 139 KRKIKDKKLPVGFTFSFPCQQSKIDEAILITWTKRFKASGVEGADVVKLLNKAIKKRGDY 198
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
+ ++VA+VNDTV TM++C Y+D CEVG+I+GTG NACYMEE+++++LVEGDEGRMC+NT
Sbjct: 199 DANIVAVVNDTVGTMMTCGYDDQHCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINT 258
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD G L++ E+DR +D S NPG+QL+EK++ G Y+GELVRL+L+++ E LL
Sbjct: 259 EWGAFGDDGSLEDIRTEFDREIDRGSLNPGKQLFEKMVSGMYLGELVRLILVKMAKEGLL 318
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F G + +L TRG F T VS +E + IL+ LG+ PS DC V+ C VS
Sbjct: 319 FEGRITPELLTRGKFNTSDVSAIEKNKEGLHNAKEILTRLGVEPSDDDCVSVQHVCTIVS 378
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
R+A++ +A L ++NR+R+++ +R TVGVDGS+YK HP + RFH ++RRL P +
Sbjct: 379 FRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKTHPQYSRRFHKTLRRLVPDSD 438
Query: 437 ITFIESEEGSGRGAALVSAVACKKA 461
+ F+ SE GSG+GAA+V+AVA + A
Sbjct: 439 VRFLLSESGSGKGAAMVTAVAYRLA 463
>gi|156151420 hexokinase domain containing 1 [Homo sapiens]
Length = 917
Score = 493 bits (1269), Expect = e-139
Identities = 237/450 (52%), Positives = 325/450 (72%), Gaps = 3/450 (0%)
Query: 8 SQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTP 67
S+ Q ++++LA FQL E L V +M+ E++ GL+ ++H A+V+MLPTYV P
Sbjct: 461 SRVQAQRKQIDRVLALFQLTREQLVDVQAKMRAELEYGLKKKSHGLATVRMLPTYVCGLP 520
Query: 68 EGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYI 127
+G+E G FL+LDLGGTNFRV+LVK+ G SV+ +++++IP + M GT E LFD+I
Sbjct: 521 DGTEKGKFLALDLGGTNFRVLLVKIRSGRR---SVRMYNKIFAIPLEIMQGTGEELFDHI 577
Query: 128 SECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLR 187
+CI+DFLD +K LPLGFTFSFP R IDKG L+ WTKGFKA+ EG +VV +LR
Sbjct: 578 VQCIADFLDYMGLKGASLPLGFTFSFPCRQMSIDKGTLIGWTKGFKATDCEGEDVVDMLR 637
Query: 188 DAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEG 247
+AIKRR +F++D+VA+VNDTV TM++C YED CE+G+I GTG N CYME+M+N+E+VEG
Sbjct: 638 EAIKRRNEFDLDIVAVVNDTVGTMMTCGYEDPNCEIGLIAGTGSNMCYMEDMRNIEMVEG 697
Query: 248 DEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVL 307
EG+MC+NTEWG FGD+G +D+ YD VDE S NPG+Q YEK+ G Y+GE+VR +L
Sbjct: 698 GEGKMCINTEWGGFGDNGCIDDIRTRYDTEVDEGSLNPGKQRYEKMTSGMYLGEIVRQIL 757
Query: 308 LRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDI 367
+ L + LLF G+ SE+LRTRG FET+F+SQ+ESD Q+ IL LGL + D +
Sbjct: 758 IDLTKQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIV 817
Query: 368 VRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHAS 427
V+ C +VS RAA +C AGLA ++ + RE + + +RITVGVDG++YKLHP F +
Sbjct: 818 VKEVCGAVSRRAAQLCGAGLAAIVEKRREDQGLEHLRITVGVDGTLYKLHPHFSRILQET 877
Query: 428 VRRLTPSCEITFIESEEGSGRGAALVSAVA 457
V+ L P C++TF+ SE+GSG+GAAL++AVA
Sbjct: 878 VKELAPRCDVTFMLSEDGSGKGAALITAVA 907
Score = 469 bits (1207), Expect = e-132
Identities = 221/443 (49%), Positives = 316/443 (71%), Gaps = 2/443 (0%)
Query: 17 VEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFL 76
V++ L +L ++ L +MRR + EM++GL +T+ A+VKMLPT+VR+ P+GSE G+FL
Sbjct: 22 VDRFLYHMRLSDDTLLDIMRRFRAEMEKGLAKDTNPTAAVKMLPTFVRAIPDGSENGEFL 81
Query: 77 SLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLD 136
SLDLGG+ FRV+ V+V E EG+ V+ + Q Y P + + G LF+Y+++C++DF+
Sbjct: 82 SLDLGGSKFRVLKVQVAE--EGKRHVQMESQFYPTPNEIIRGNGTELFEYVADCLADFMK 139
Query: 137 KHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDF 196
+KHKKLPLG TFSFP R +++G+LL+WTK FKA G + +VV L A++R D
Sbjct: 140 TKDLKHKKLPLGLTFSFPCRQTKLEEGVLLSWTKKFKARGVQDTDVVSRLTKAMRRHKDM 199
Query: 197 EMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNT 256
++D++A+VNDTV TM++C Y+D CEVG+I+GTG NACYME+M N++LVEGDEGRMC+NT
Sbjct: 200 DVDILALVNDTVGTMMTCAYDDPYCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINT 259
Query: 257 EWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLL 316
EWGAFGD G L++ E+DR +D S NPG+QL+EK+I G Y+GELVRL+LL++ LL
Sbjct: 260 EWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYLGELVRLILLKMAKAGLL 319
Query: 317 FHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVS 376
F GE S L T+G ETR V+ +E IL LGL PS DC V+ C VS
Sbjct: 320 FGGEKSSALHTKGKIETRHVAAMEKYKEGLANTREILVDLGLEPSEADCIAVQHVCTIVS 379
Query: 377 TRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCE 436
R+A++C+A LA ++ R+RE++ + +R TVG+DG++YK+HP + +R H VR+L PSC+
Sbjct: 380 FRSANLCAAALAAILTRLRENKKVERLRTTVGMDGTLYKIHPQYPKRLHKVVRKLVPSCD 439
Query: 437 ITFIESEEGSGRGAALVSAVACK 459
+ F+ SE GS +GAA+V+AVA +
Sbjct: 440 VRFLLSESGSTKGAAMVTAVASR 462
>gi|194097330 hexokinase 3 [Homo sapiens]
Length = 923
Score = 474 bits (1220), Expect = e-134
Identities = 236/446 (52%), Positives = 322/446 (72%), Gaps = 9/446 (2%)
Query: 16 LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDF 75
L+E+ LA F+L + L V +M+K M +GLR E +S++MLPT+VR+TP+GSE GDF
Sbjct: 482 LLEETLAPFRLNHDQLAAVQAQMRKAMAKGLR---GEASSLRMLPTFVRATPDGSERGDF 538
Query: 76 LSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFL 135
L+LDLGGTNFRV+LV+V G V+ ++YSIPE G+ + LFD+I +CI DF
Sbjct: 539 LALDLGGTNFRVLLVRVTTG------VQITSEIYSIPETVAQGSGQQLFDHIVDCIVDFQ 592
Query: 136 DKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGD 195
K + + LPLGFTFSFP R +D+GILLNWTKGFKAS EG +VV LLR+AI RR
Sbjct: 593 QKQGLSGQSLPLGFTFSFPCRQLGLDQGILLNWTKGFKASDCEGQDVVSLLREAITRRQA 652
Query: 196 FEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVN 255
E++VVA+VNDTV TM+SC YED +CE+G+IVGTG NACYMEE++NV V GD GRMC+N
Sbjct: 653 VELNVVAIVNDTVGTMMSCGYEDPRCEIGLIVGTGTNACYMEELRNVAGVPGDSGRMCIN 712
Query: 256 TEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENL 315
EWGAFGD G L +D VD++S NPG+Q +EK+I G Y+GE+VR +LL L +
Sbjct: 713 MEWGAFGDDGSLAMLSTRFDASVDQASINPGKQRFEKMISGMYLGEIVRHILLHLTSLGV 772
Query: 316 LFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESV 375
LF G+ ++L+TR F+T+F+S++ESD+ +Q+ IL LGL ++ D +V C++V
Sbjct: 773 LFRGQQIQRLQTRDIFKTKFLSEIESDSLALRQVRAILEDLGLPLTSDDALMVLEVCQAV 832
Query: 376 STRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSC 435
S RAA +C AG+A V+ ++RE+R + + ++VGVDG++YKLHP F A+VR L P C
Sbjct: 833 SQRAAQLCGAGVAAVVEKIRENRGLEELAVSVGVDGTLYKLHPRFSSLVAATVRELAPRC 892
Query: 436 EITFIESEEGSGRGAALVSAVACKKA 461
+TF++SE+GSG+GAALV+AVAC+ A
Sbjct: 893 VVTFLQSEDGSGKGAALVTAVACRLA 918
Score = 375 bits (962), Expect = e-104
Identities = 189/448 (42%), Positives = 284/448 (63%), Gaps = 4/448 (0%)
Query: 16 LVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDF 75
LV++ L +F++ L+++ + M++ LR + +V+MLPTYV STP G+E GDF
Sbjct: 32 LVQECLQQFKVTRAQLQQIQASLLGSMEQALRGQASPAPAVRMLPTYVGSTPHGTEQGDF 91
Query: 76 LSLDLG--GTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISD 133
+ L+LG G + RV+ V + G EG V+ + Q + IP++ M G + LFD+ + C+S+
Sbjct: 92 VVLELGATGASLRVLWVTL-TGIEGH-RVEPRSQEFVIPQEVMLGAGQQLFDFAAHCLSE 149
Query: 134 FLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRR 193
FLD + + L LGF+FSFP +D+ L++WTKGF+ SG EG +VV LLRDAI+R+
Sbjct: 150 FLDAQPVNKQGLQLGFSFSFPCHQTGLDRSTLISWTKGFRCSGVEGQDVVQLLRDAIRRQ 209
Query: 194 GDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMC 253
G + +DVVA+VNDTV TM+ C CEVG++V TG NACYMEE ++V +++ D GR+C
Sbjct: 210 GAYNIDVVAVVNDTVGTMMGCEPGVRPCEVGLVVDTGTNACYMEEARHVAVLDEDRGRVC 269
Query: 254 VNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDE 313
V+ EWG+F D G L L +D +D S NPG Q +EK+IGG Y+GELVRLVL L
Sbjct: 270 VSVEWGSFSDDGALGPVLTTFDHTLDHESLNPGAQRFEKMIGGLYLGELVRLVLAHLARC 329
Query: 314 NLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACE 373
+LF G S L ++G+ V+++E + +++ IL LGL P +D ++V+ C
Sbjct: 330 GVLFGGCTSPALLSQGSILLEHVAEMEDPSTGAARVHAILQDLGLSPGASDVELVQHVCA 389
Query: 374 SVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTP 433
+V TRAA +C+A LA V++ ++ SR + +++ V G V + HP F +V L P
Sbjct: 390 AVCTRAAQLCAAALAAVLSCLQHSREQQTLQVAVATGGRVCERHPRFCSVLQGTVMLLAP 449
Query: 434 SCEITFIESEEGSGRGAALVSAVACKKA 461
C+++ I S +G GRG A+V+AVA + A
Sbjct: 450 ECDVSLIPSVDGGGRGVAMVTAVAARLA 477
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 32.7 bits (73), Expect = 0.72
Identities = 21/62 (33%), Positives = 36/62 (58%), Gaps = 9/62 (14%)
Query: 3 MDVTRSQAQTALTLVEQILAEFQLQEEDLKKVMRRMQKEMDR------GLRLETHEEASV 56
++V S+ +T LTL++Q E + +EE+L+ V+R+M K L+LE HE +
Sbjct: 1659 LNVQISERKTQLTLIKQ---EIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGL 1715
Query: 57 KM 58
K+
Sbjct: 1716 KL 1717
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 30.8 bits (68), Expect = 2.7
Identities = 16/52 (30%), Positives = 31/52 (59%), Gaps = 1/52 (1%)
Query: 3 MDVTRSQAQTALTLV-EQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEE 53
++ R+Q Q+ L E++LA + ++E+L + + +Q+E D GL L E+
Sbjct: 1009 LEAERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEK 1060
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 29.6 bits (65), Expect = 6.1
Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 4/36 (11%)
Query: 418 PSFKERFHASVRRLTPSCEIT----FIESEEGSGRG 449
PS E ++RR TPSCE T +E EGSG G
Sbjct: 2200 PSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAG 2235
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 29.6 bits (65), Expect = 6.1
Identities = 17/36 (47%), Positives = 20/36 (55%), Gaps = 4/36 (11%)
Query: 418 PSFKERFHASVRRLTPSCEIT----FIESEEGSGRG 449
PS E ++RR TPSCE T +E EGSG G
Sbjct: 2206 PSAAEGGSTTLRRRTPSCEATPHRDSLEPTEGSGAG 2241
>gi|160948610 E3 ubiquitin-protein ligase UBR3 [Homo sapiens]
Length = 1888
Score = 29.6 bits (65), Expect = 6.1
Identities = 18/93 (19%), Positives = 42/93 (45%), Gaps = 23/93 (24%)
Query: 178 EGNNVVGLLRDAIKRRG--------DFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVG- 228
+ ++V+G RD ++ + + D A V+D +++ Y++D C + + +G
Sbjct: 1258 QASSVLGQCRDNVEPKKLPISEEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGW 1317
Query: 229 --------------TGCNACYMEEMQNVELVEG 247
C+ YME ++N ++++G
Sbjct: 1318 EGGVYVQTCGHTLHIDCHKSYMESLRNDQVLQG 1350
>gi|117414143 hypothetical protein LOC55603 [Homo sapiens]
Length = 442
Score = 29.3 bits (64), Expect = 8.0
Identities = 23/101 (22%), Positives = 44/101 (43%), Gaps = 10/101 (9%)
Query: 118 GTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRH----EDIDKGILLNWTKGFK 173
G + + D + +C+ DFL + K K PL ++ + D D+ L++
Sbjct: 152 GEFQTVKDVVLDCLLDFLPEGVNKEKITPLTLKEAYVQKMVKVCNDSDRWSLIS------ 205
Query: 174 ASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISC 214
S G NV D+++R+ +F +D + D++ C
Sbjct: 206 LSNNSGKNVELKFVDSLRRQFEFSVDSFQIKLDSLLLFYEC 246
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,431,041
Number of Sequences: 37866
Number of extensions: 711565
Number of successful extensions: 1825
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 11
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 1788
Number of HSP's gapped (non-prelim): 26
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.